locus-tag	class	description
C6Y50_RS00010	COG1295	ribonuclease BN
C6Y50_RS00015	COG1393	Belongs to the ArsC family
C6Y50_RS00030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6Y50_RS00035	COG0628	permease
C6Y50_RS00045	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C6Y50_RS00050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C6Y50_RS00065	COG0436	Aminotransferase
C6Y50_RS00080	COG1393	Belongs to the ArsC family
C6Y50_RS00085	COG2171	N-acyltransferase activity
C6Y50_RS00090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C6Y50_RS00095	COG2166	iron-sulfur cluster assembly
C6Y50_RS00105	COG3258	Cytochrome c
C6Y50_RS00110	COG2863	cytochrome
C6Y50_RS00120	COG3530	Putative quorum-sensing-regulated virulence factor
C6Y50_RS00130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C6Y50_RS00140	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C6Y50_RS00145	COG3932	Exopolysaccharide synthesis, ExoD
C6Y50_RS00150	COG0583	DNA-binding transcription factor activity
C6Y50_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS00165	COG1280	lysine exporter protein (LysE YggA)
C6Y50_RS00185	COG1462	curli production assembly transport component CsgG
C6Y50_RS00205	COG1309	transcriptional regulator
C6Y50_RS00210	COG0583	DNA-binding transcription factor activity
C6Y50_RS00215	COG0189	ligase activity
C6Y50_RS00215	COG4067	protein conserved in archaea
C6Y50_RS00225	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y50_RS00225	COG0116	Belongs to the methyltransferase superfamily
C6Y50_RS00230	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C6Y50_RS00245	COG0604	alcohol dehydrogenase
C6Y50_RS00245	COG3321	synthase
C6Y50_RS00255	COG3284	Transcriptional regulator
C6Y50_RS00270	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C6Y50_RS00275	COG1063	alcohol dehydrogenase
C6Y50_RS00280	COG0022	dehydrogenase e1 component
C6Y50_RS00285	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y50_RS00290	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y50_RS00320	COG0583	DNA-binding transcription factor activity
C6Y50_RS00325	COG0625	glutathione transferase activity
C6Y50_RS00350	COG0659	secondary active sulfate transmembrane transporter activity
C6Y50_RS00360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y50_RS00370	COG1696	Membrane protein involved in D-alanine export
C6Y50_RS00380	COG1280	lysine exporter protein (LysE YggA)
C6Y50_RS00400	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
C6Y50_RS00410	COG4249	Peptidase C14 caspase catalytic subunit p20
C6Y50_RS00415	COG1132	(ABC) transporter
C6Y50_RS00435	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C6Y50_RS00445	COG1404	Belongs to the peptidase S8 family
C6Y50_RS00460	COG0159	tryptophan synthase activity
C6Y50_RS00475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS00485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y50_RS00495	COG4221	oxidoreductase activity
C6Y50_RS00505	COG2207	Transcriptional regulator
C6Y50_RS00510	COG3845	ABC transporter
C6Y50_RS00515	COG4603	Belongs to the binding-protein-dependent transport system permease family
C6Y50_RS00520	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y50_RS00540	COG1301	dicarboxylic acid transport
C6Y50_RS00550	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6Y50_RS00555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y50_RS00565	COG0490	domain, Protein
C6Y50_RS00565	COG0471	metal ion transport
C6Y50_RS00575	COG2814	Major facilitator Superfamily
C6Y50_RS00595	COG0596	Alpha beta hydrolase
C6Y50_RS00595	COG0508	dehydrogenase complex catalyzes the overall conversion of
C6Y50_RS00620	COG1279	arginine transmembrane transporter activity
C6Y50_RS00645	COG2733	membrane
C6Y50_RS00665	COG0537	adenosine 5'-monophosphoramidase activity
C6Y50_RS00675	COG2258	MOSC domain
C6Y50_RS00690	COG3795	YCII-related domain
C6Y50_RS00705	COG2851	Citrate transporter
C6Y50_RS00715	COG1234	tRNA 3'-trailer cleavage
C6Y50_RS00730	COG3257	ureidoglycine aminohydrolase activity
C6Y50_RS00735	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
C6Y50_RS00740	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
C6Y50_RS00745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6Y50_RS00750	COG0631	protein serine/threonine phosphatase activity
C6Y50_RS00755	COG0515	serine threonine protein kinase
C6Y50_RS00755	COG2815	serine threonine protein kinase
C6Y50_RS00770	COG1643	Atp-dependent helicase
C6Y50_RS00800	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS00805	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS00810	COG2030	dehydratase
C6Y50_RS00835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y50_RS00845	COG0443	Heat shock 70 kDa protein
C6Y50_RS00850	COG2271	Major facilitator Superfamily
C6Y50_RS00855	COG3622	Belongs to the hyi family
C6Y50_RS00860	COG2084	Dehydrogenase
C6Y50_RS00865	COG1968	undecaprenyl-diphosphatase activity
C6Y50_RS00875	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C6Y50_RS00885	COG3639	organic phosphonate transmembrane transporter activity
C6Y50_RS00890	COG3639	organic phosphonate transmembrane transporter activity
C6Y50_RS00940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C6Y50_RS00975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y50_RS00980	COG0556	nucleotide-excision repair
C6Y50_RS01000	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C6Y50_RS01010	COG3842	ATPase activity
C6Y50_RS01015	COG0590	tRNA wobble adenosine to inosine editing
C6Y50_RS01020	COG2132	Multicopper oxidase
C6Y50_RS01025	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C6Y50_RS01025	COG0519	Catalyzes the synthesis of GMP from XMP
C6Y50_RS01040	COG1570	exodeoxyribonuclease VII activity
C6Y50_RS01045	COG0739	heme binding
C6Y50_RS01055	COG0668	transmembrane transport
C6Y50_RS01070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y50_RS01075	COG1064	alcohol dehydrogenase
C6Y50_RS01085	COG2356	endonuclease I
C6Y50_RS01090	COG3647	Membrane
C6Y50_RS01100	COG2264	protein methyltransferase activity
C6Y50_RS01115	COG0436	Aminotransferase
C6Y50_RS01120	COG1045	serine acetyltransferase
C6Y50_RS01125	COG1160	GTP binding
C6Y50_RS01135	COG2976	Protein conserved in bacteria
C6Y50_RS01140	COG0124	histidyl-tRNA synthetase
C6Y50_RS01145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C6Y50_RS01160	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6Y50_RS01165	COG0105	UTP biosynthetic process
C6Y50_RS01180	COG0443	Heat shock 70 kDa protein
C6Y50_RS01185	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6Y50_RS01190	COG0316	Belongs to the HesB IscA family
C6Y50_RS01200	COG1104	cysteine desulfurase activity
C6Y50_RS01225	COG3134	Outer membrane lipoprotein
C6Y50_RS01240	COG1862	Preprotein translocase
C6Y50_RS01260	COG1278	Cold shock
C6Y50_RS01270	COG0795	lipopolysaccharide-transporting ATPase activity
C6Y50_RS01275	COG0795	lipopolysaccharide-transporting ATPase activity
C6Y50_RS01295	COG3179	chitinase
C6Y50_RS01395	COG0582	viral genome integration into host DNA
C6Y50_RS01400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C6Y50_RS01430	COG0471	metal ion transport
C6Y50_RS01430	COG0490	domain, Protein
C6Y50_RS01435	COG0477	Major facilitator Superfamily
C6Y50_RS01440	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
C6Y50_RS01460	COG3081	Nucleoid-associated protein
C6Y50_RS01465	COG2326	polyphosphate kinase activity
C6Y50_RS01485	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C6Y50_RS01490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C6Y50_RS01530	COG0402	S-adenosylhomocysteine deaminase activity
C6Y50_RS01535	COG0803	Belongs to the bacterial solute-binding protein 9 family
C6Y50_RS01545	COG1121	(ABC) transporter
C6Y50_RS01550	COG1802	Transcriptional regulator
C6Y50_RS01555	COG2252	PERMEase
C6Y50_RS01580	COG4266	Belongs to the allantoicase family
C6Y50_RS01585	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
C6Y50_RS01595	COG2233	PERMEase
C6Y50_RS01600	COG4651	solute:proton antiporter activity
C6Y50_RS01600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6Y50_RS01605	COG2233	PERMEase
C6Y50_RS01620	COG0840	transmembrane signaling receptor activity
C6Y50_RS01625	COG1309	transcriptional regulator
C6Y50_RS01650	COG5001	Diguanylate cyclase
C6Y50_RS01650	COG3300	MHYT domain
C6Y50_RS01655	COG0708	Exodeoxyribonuclease III
C6Y50_RS01675	COG2351	hydroxyisourate hydrolase activity
C6Y50_RS01680	COG0583	DNA-binding transcription factor activity
C6Y50_RS01685	COG3960	tartronate-semialdehyde synthase activity
C6Y50_RS01690	COG3622	Belongs to the hyi family
C6Y50_RS01695	COG2084	Dehydrogenase
C6Y50_RS01705	COG0469	pyruvate kinase activity
C6Y50_RS01710	COG4413	Urea transporter
C6Y50_RS01720	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y50_RS01720	COG1017	nitric oxide dioxygenase activity
C6Y50_RS01735	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C6Y50_RS01740	COG3706	GGDEF domain
C6Y50_RS01760	COG0583	DNA-binding transcription factor activity
C6Y50_RS01765	COG1279	arginine transmembrane transporter activity
C6Y50_RS01790	COG1704	LemA family
C6Y50_RS01820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y50_RS01825	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y50_RS01835	COG0459	protein refolding
C6Y50_RS01840	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C6Y50_RS01845	COG3030	protein affecting phage T7 exclusion by the F plasmid
C6Y50_RS01855	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS01875	COG0668	transmembrane transport
C6Y50_RS01880	COG1666	GTP binding
C6Y50_RS01885	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS01895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y50_RS01895	COG4191	Histidine kinase
C6Y50_RS01900	COG2096	Adenosyltransferase
C6Y50_RS01930	COG0494	nUDIX hydrolase
C6Y50_RS01940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C6Y50_RS01945	COG0653	protein targeting
C6Y50_RS01985	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C6Y50_RS01990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C6Y50_RS02010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C6Y50_RS02015	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C6Y50_RS02025	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C6Y50_RS02030	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C6Y50_RS02040	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
C6Y50_RS02045	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C6Y50_RS02065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C6Y50_RS02090	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6Y50_RS02120	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS02125	COG4294	response to UV
C6Y50_RS02130	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS02135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C6Y50_RS02140	COG1024	Enoyl-CoA hydratase
C6Y50_RS02170	COG0789	Transcriptional regulator
C6Y50_RS02175	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6Y50_RS02185	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y50_RS02200	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6Y50_RS02230	COG0697	spore germination
C6Y50_RS02235	COG0288	reversible hydration of carbon dioxide
C6Y50_RS02240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
C6Y50_RS02255	COG0456	acetyltransferase
C6Y50_RS02265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y50_RS02285	COG2851	Citrate transporter
C6Y50_RS02295	COG0019	diaminopimelate decarboxylase activity
C6Y50_RS02315	COG3008	intermembrane lipid transfer
C6Y50_RS02320	COG2995	paraquat-inducible protein a
C6Y50_RS02325	COG2995	paraquat-inducible protein a
C6Y50_RS02370	COG1183	phosphatidylcholine synthase activity
C6Y50_RS02375	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C6Y50_RS02385	COG0028	Belongs to the TPP enzyme family
C6Y50_RS02405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y50_RS02440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C6Y50_RS02455	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C6Y50_RS02470	COG2264	protein methyltransferase activity
C6Y50_RS02490	COG0138	bifunctional purine biosynthesis protein purh
C6Y50_RS02500	COG0784	Response regulator, receiver
C6Y50_RS02500	COG5002	protein histidine kinase activity
C6Y50_RS02500	COG2205	protein histidine kinase activity
C6Y50_RS02505	COG2124	cytochrome p450
C6Y50_RS02520	COG0679	Auxin Efflux Carrier
C6Y50_RS02535	COG0436	Aminotransferase
C6Y50_RS02540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6Y50_RS02545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y50_RS02555	COG4191	Histidine kinase
C6Y50_RS02575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C6Y50_RS02580	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C6Y50_RS02585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C6Y50_RS02590	COG0166	Belongs to the GPI family
C6Y50_RS02600	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y50_RS02625	COG1185	polyribonucleotide nucleotidyltransferase activity
C6Y50_RS02630	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C6Y50_RS02635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C6Y50_RS02640	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C6Y50_RS02645	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C6Y50_RS02650	COG2251	uridine kinase activity
C6Y50_RS02650	COG0195	Participates in both transcription termination and antitermination
C6Y50_RS02655	COG0779	Required for maturation of 30S ribosomal subunits
C6Y50_RS02670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C6Y50_RS02675	COG0149	triose-phosphate isomerase activity
C6Y50_RS02680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C6Y50_RS02685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C6Y50_RS02715	COG0505	Belongs to the CarA family
C6Y50_RS02720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C6Y50_RS02725	COG0484	heat shock protein binding
C6Y50_RS02730	COG0443	Heat shock 70 kDa protein
C6Y50_RS02735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C6Y50_RS02740	COG0497	DNA recombination
C6Y50_RS02750	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y50_RS02755	COG2914	Belongs to the UPF0125 (RnfH) family
C6Y50_RS02765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C6Y50_RS02775	COG1620	l-lactate permease
C6Y50_RS02780	COG0247	lactate metabolic process
C6Y50_RS02815	COG1280	lysine exporter protein (LysE YggA)
C6Y50_RS02830	COG0366	Alpha amylase catalytic
C6Y50_RS02850	COG2909	trisaccharide binding
C6Y50_RS02855	COG3833	ABC-type maltose transport systems, permease component
C6Y50_RS02860	COG1175	transmembrane transport
C6Y50_RS02870	COG0366	Alpha amylase catalytic
C6Y50_RS02890	COG4580	involved in the transport of maltose and maltodextrins
C6Y50_RS02905	COG4989	oxidoreductase activity
C6Y50_RS02915	COG0800	Aldolase
C6Y50_RS02930	COG1737	Transcriptional regulator
C6Y50_RS02950	COG2814	Major facilitator Superfamily
C6Y50_RS03000	COG3154	lipid carrier protein
C6Y50_RS03005	COG0826	peptidase U32
C6Y50_RS03010	COG0826	peptidase U32
C6Y50_RS03020	COG3604	Transcriptional regulator
C6Y50_RS03055	COG3256	nitric oxide reductase
C6Y50_RS03060	COG2010	Cytochrome c
C6Y50_RS03085	COG3391	amine dehydrogenase activity
C6Y50_RS03090	COG2010	Cytochrome c
C6Y50_RS03110	COG2010	Cytochrome c
C6Y50_RS03115	COG0714	Associated with various cellular activities
C6Y50_RS03120	COG1845	cytochrome c oxidase, subunit III
C6Y50_RS03130	COG0535	radical SAM domain protein
C6Y50_RS03135	COG1648	precorrin-2 dehydrogenase activity
C6Y50_RS03135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y50_RS03150	COG0517	IMP dehydrogenase activity
C6Y50_RS03150	COG0617	tRNA 3'-terminal CCA addition
C6Y50_RS03150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C6Y50_RS03155	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y50_RS03160	COG0840	transmembrane signaling receptor activity
C6Y50_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS03185	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C6Y50_RS03200	COG4263	nitrous-oxide reductase activity
C6Y50_RS03205	COG3901	Regulator of nitric oxide reductase transcription
C6Y50_RS03205	COG0348	domain, Protein
C6Y50_RS03210	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS03225	COG3189	MarR family transcriptional regulator
C6Y50_RS03240	COG0492	ferredoxin-NADP+ reductase activity
C6Y50_RS03245	COG1760	l-serine dehydratase
C6Y50_RS03265	COG2154	pterin-4-alpha-carbinolamine dehydratase
C6Y50_RS03280	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
C6Y50_RS03295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C6Y50_RS03300	COG0402	S-adenosylhomocysteine deaminase activity
C6Y50_RS03310	COG1607	acyl-coa hydrolase
C6Y50_RS03315	COG2824	Alkylphosphonate utilization operon protein PhnA
C6Y50_RS03320	COG1278	Cold shock
C6Y50_RS03345	COG1079	Belongs to the binding-protein-dependent transport system permease family
C6Y50_RS03355	COG3845	ABC transporter
C6Y50_RS03390	COG0346	lactoylglutathione lyase activity
C6Y50_RS03400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y50_RS03410	COG4977	sequence-specific DNA binding
C6Y50_RS03425	COG1309	transcriptional regulator
C6Y50_RS03430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y50_RS03435	COG1335	isochorismatase
C6Y50_RS03440	COG0251	oxidation-reduction process
C6Y50_RS03445	COG0596	Alpha beta hydrolase
C6Y50_RS03450	COG0778	Nitroreductase
C6Y50_RS03455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C6Y50_RS03485	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C6Y50_RS03490	COG2814	Major facilitator Superfamily
C6Y50_RS03495	COG1309	transcriptional regulator
C6Y50_RS03505	COG2217	Heavy metal translocating P-type atpase
C6Y50_RS03530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y50_RS03545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C6Y50_RS03545	COG2169	Transcriptional regulator
C6Y50_RS03555	COG0084	hydrolase, TatD family'
C6Y50_RS03560	COG0840	transmembrane signaling receptor activity
C6Y50_RS03570	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6Y50_RS03575	COG1515	deoxyribonuclease V activity
C6Y50_RS03585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y50_RS03595	COG2945	thiolester hydrolase activity
C6Y50_RS03620	COG1252	NADH dehydrogenase
C6Y50_RS03695	COG3300	MHYT domain
C6Y50_RS03695	COG5001	Diguanylate cyclase
C6Y50_RS03700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C6Y50_RS03705	COG0305	Participates in initiation and elongation during chromosome replication
C6Y50_RS03710	COG0359	binds to the 23S rRNA
C6Y50_RS03720	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C6Y50_RS03725	COG0360	Binds together with S18 to 16S ribosomal RNA
C6Y50_RS03730	COG0784	Response regulator, receiver
C6Y50_RS03730	COG4191	Histidine kinase
C6Y50_RS03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C6Y50_RS03740	COG0557	exoribonuclease II activity
C6Y50_RS03755	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C6Y50_RS03760	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C6Y50_RS03765	COG0330	HflC and HflK could
C6Y50_RS03770	COG0330	HflC and HflK could
C6Y50_RS03775	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C6Y50_RS03780	COG1923	regulation of RNA biosynthetic process
C6Y50_RS03785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C6Y50_RS03790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C6Y50_RS03795	COG0860	N-Acetylmuramoyl-L-alanine amidase
C6Y50_RS03800	COG0802	atpase or kinase
C6Y50_RS03805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C6Y50_RS03805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C6Y50_RS03830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6Y50_RS03840	COG0531	amino acid
C6Y50_RS03845	COG4303	Ethanolamine ammonia lyase large subunit
C6Y50_RS03865	COG3228	Belongs to the MtfA family
C6Y50_RS03890	COG5001	Diguanylate cyclase
C6Y50_RS03890	COG3300	MHYT domain
C6Y50_RS03900	COG0076	glutamate decarboxylase activity
C6Y50_RS03905	COG3486	L-lysine 6-monooxygenase (NADPH) activity
C6Y50_RS03930	COG1722	exodeoxyribonuclease VII activity
C6Y50_RS03935	COG0142	geranyltranstransferase activity
C6Y50_RS03940	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C6Y50_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS03970	COG1643	Atp-dependent helicase
C6Y50_RS03990	COG1522	sequence-specific DNA binding
C6Y50_RS04040	COG0829	nickel cation binding
C6Y50_RS04045	COG0831	urea catabolic process
C6Y50_RS04055	COG0832	Belongs to the urease beta subunit family
C6Y50_RS04060	COG0804	urea catabolic process
C6Y50_RS04065	COG1953	Uracil, thiamine, allantoin
C6Y50_RS04075	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C6Y50_RS04085	COG2814	Major facilitator Superfamily
C6Y50_RS04090	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C6Y50_RS04105	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
C6Y50_RS04110	COG0830	nickel cation binding
C6Y50_RS04120	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
C6Y50_RS04135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C6Y50_RS04140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y50_RS04155	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS04160	COG2205	protein histidine kinase activity
C6Y50_RS04160	COG3437	response regulator, receiver
C6Y50_RS04160	COG3850	Histidine kinase
C6Y50_RS04160	COG4999	Histidine kinase
C6Y50_RS04165	COG0351	phosphomethylpyrimidine kinase
C6Y50_RS04165	COG0352	thiamine-phosphate diphosphorylase activity
C6Y50_RS04170	COG0352	thiamine-phosphate diphosphorylase activity
C6Y50_RS04175	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C6Y50_RS04190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y50_RS04195	COG1702	phosphate starvation-inducible protein PhoH
C6Y50_RS04200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C6Y50_RS04205	COG4535	Mg2 and Co2 transporter CorC
C6Y50_RS04210	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C6Y50_RS04225	COG0495	leucyl-tRNA aminoacylation
C6Y50_RS04240	COG3036	rescue of stalled ribosome
C6Y50_RS04245	COG2951	lytic endotransglycosylase activity
C6Y50_RS04265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C6Y50_RS04270	COG0321	lipoyl(octanoyl) transferase activity
C6Y50_RS04275	COG2921	Belongs to the UPF0250 family
C6Y50_RS04280	COG1686	Belongs to the peptidase S11 family
C6Y50_RS04290	COG2951	lytic endotransglycosylase activity
C6Y50_RS04295	COG0772	Belongs to the SEDS family
C6Y50_RS04300	COG0768	penicillin binding
C6Y50_RS04305	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C6Y50_RS04315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C6Y50_RS04320	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C6Y50_RS04325	COG0586	Pfam SNARE associated Golgi protein
C6Y50_RS04335	COG1346	cytolysis
C6Y50_RS04355	COG0702	epimerase
C6Y50_RS04360	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C6Y50_RS04370	COG1162	GTPase activity
C6Y50_RS04375	COG1360	Flagellar Motor Protein
C6Y50_RS04380	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6Y50_RS04395	COG0688	phosphatidylethanolamine metabolic process
C6Y50_RS04405	COG2200	EAL domain
C6Y50_RS04410	COG1063	alcohol dehydrogenase
C6Y50_RS04415	COG0560	Phosphoserine phosphatase
C6Y50_RS04415	COG3830	Belongs to the UPF0237 family
C6Y50_RS04450	COG3150	esterase
C6Y50_RS04455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C6Y50_RS04465	COG0494	nUDIX hydrolase
C6Y50_RS04475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C6Y50_RS04480	COG1538	Outer membrane efflux protein
C6Y50_RS04485	COG1519	Transferase
C6Y50_RS04500	COG0667	Aldo Keto reductase
C6Y50_RS04510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C6Y50_RS04510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C6Y50_RS04525	COG1132	(ABC) transporter
C6Y50_RS04560	COG0438	transferase activity, transferring glycosyl groups
C6Y50_RS04565	COG2192	nodulation
C6Y50_RS04590	COG0438	transferase activity, transferring glycosyl groups
C6Y50_RS04595	COG0859	PFAM glycosyl transferase family 9
C6Y50_RS04600	COG0859	PFAM glycosyl transferase family 9
C6Y50_RS04610	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C6Y50_RS04635	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y50_RS04640	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS04650	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS04670	COG1073	alpha beta
C6Y50_RS04670	COG2226	methyltransferase
C6Y50_RS04675	COG0156	8-amino-7-oxononanoate synthase activity
C6Y50_RS04680	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C6Y50_RS04685	COG1040	competence protein
C6Y50_RS04690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C6Y50_RS04695	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C6Y50_RS04730	COG1304	FMN binding
C6Y50_RS04740	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS04745	COG3263	regulation of cellular component size
C6Y50_RS04750	COG3264	Mechanosensitive ion channel
C6Y50_RS04750	COG1196	nuclear chromosome segregation
C6Y50_RS04755	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
C6Y50_RS04760	COG5002	protein histidine kinase activity
C6Y50_RS04770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6Y50_RS04775	COG2205	protein histidine kinase activity
C6Y50_RS04775	COG2198	Histidine kinase
C6Y50_RS04775	COG0784	Response regulator, receiver
C6Y50_RS04805	COG0330	HflC and HflK could
C6Y50_RS04835	COG4774	siderophore transport
C6Y50_RS04845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y50_RS04855	COG2721	sulfolactate sulfo-lyase activity
C6Y50_RS04865	COG1012	belongs to the aldehyde dehydrogenase family
C6Y50_RS04870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y50_RS04900	COG0583	DNA-binding transcription factor activity
C6Y50_RS04915	COG2207	Transcriptional regulator
C6Y50_RS04915	COG1917	Cupin 2, conserved barrel domain protein
C6Y50_RS04930	COG1609	Transcriptional regulator
C6Y50_RS04935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y50_RS04945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y50_RS04995	COG0840	transmembrane signaling receptor activity
C6Y50_RS05025	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y50_RS05055	COG0513	Belongs to the DEAD box helicase family
C6Y50_RS05060	COG1289	transmembrane transporter activity
C6Y50_RS05070	COG2081	HI0933 family
C6Y50_RS05110	COG0191	fructose-bisphosphate aldolase activity
C6Y50_RS05125	COG0126	phosphoglycerate kinase activity
C6Y50_RS05130	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6Y50_RS05135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C6Y50_RS05140	COG0583	DNA-binding transcription factor activity
C6Y50_RS05145	COG2175	clavaminate synthase activity
C6Y50_RS05155	COG2226	methyltransferase
C6Y50_RS05160	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C6Y50_RS05170	COG0842	Transport permease protein
C6Y50_RS05175	COG1131	(ABC) transporter
C6Y50_RS05180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y50_RS05185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6Y50_RS05205	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C6Y50_RS05210	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C6Y50_RS05215	COG0513	Belongs to the DEAD box helicase family
C6Y50_RS05230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y50_RS05235	COG2353	YceI-like domain
C6Y50_RS05240	COG3038	cytochrome b561
C6Y50_RS05250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C6Y50_RS05260	COG2201	protein-glutamate methylesterase activity
C6Y50_RS05265	COG0643	Histidine kinase
C6Y50_RS05265	COG2198	Histidine kinase
C6Y50_RS05265	COG0784	Response regulator, receiver
C6Y50_RS05305	COG1678	Uncharacterized ACR, COG1678
C6Y50_RS05320	COG0540	Belongs to the ATCase OTCase family
C6Y50_RS05375	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y50_RS05380	COG2813	Specifically methylates the guanine in position
C6Y50_RS05380	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y50_RS05390	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C6Y50_RS05395	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C6Y50_RS05420	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C6Y50_RS05435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C6Y50_RS05440	COG2022	thiamine diphosphate biosynthetic process
C6Y50_RS05450	COG2363	Small membrane protein
C6Y50_RS05455	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C6Y50_RS05485	COG2177	Part of the ABC transporter FtsEX involved in
C6Y50_RS05490	COG2884	Cell division ATP-binding protein ftsE
C6Y50_RS05495	COG0552	protein localization to endoplasmic reticulum
C6Y50_RS05500	COG0612	Peptidase, M16
C6Y50_RS05505	COG0612	Peptidase, M16
C6Y50_RS05510	COG0742	ribosomal rna small subunit methyltransferase
C6Y50_RS05540	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6Y50_RS05545	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C6Y50_RS05550	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
C6Y50_RS05570	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C6Y50_RS05580	COG0693	protein deglycase activity
C6Y50_RS05595	COG0129	dihydroxy-acid dehydratase activity
C6Y50_RS05625	COG0584	glycerophosphoryl diester phosphodiesterase
C6Y50_RS05635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6Y50_RS05650	COG0704	Plays a role in the regulation of phosphate uptake
C6Y50_RS05655	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C6Y50_RS05660	COG0573	inorganic phosphate transmembrane transporter activity
C6Y50_RS05675	COG1607	acyl-coa hydrolase
C6Y50_RS05680	COG2203	Gaf domain
C6Y50_RS05680	COG3706	GGDEF domain
C6Y50_RS05680	COG5001	Diguanylate cyclase
C6Y50_RS05680	COG4251	negative regulation of phosphorylation
C6Y50_RS05695	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C6Y50_RS05700	COG1074	ATP-dependent DNA helicase activity
C6Y50_RS05705	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
C6Y50_RS05720	COG3180	Ammonia monooxygenase
C6Y50_RS05760	COG0840	transmembrane signaling receptor activity
C6Y50_RS05775	COG2358	TRAP transporter, solute receptor (TAXI family
C6Y50_RS05785	COG0700	Nucleoside recognition
C6Y50_RS05805	COG2204	response regulator
C6Y50_RS05810	COG5002	protein histidine kinase activity
C6Y50_RS05820	COG3023	N-Acetylmuramoyl-L-alanine amidase
C6Y50_RS05845	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C6Y50_RS05850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y50_RS05850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C6Y50_RS05865	COG1178	ABC-type Fe3 transport system permease component
C6Y50_RS05875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y50_RS05885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C6Y50_RS05890	COG0006	proline dipeptidase activity
C6Y50_RS05895	COG3079	Belongs to the UPF0149 family
C6Y50_RS05915	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C6Y50_RS05935	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
C6Y50_RS05945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6Y50_RS05950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C6Y50_RS05955	COG4942	peptidase
C6Y50_RS05960	COG0793	Belongs to the peptidase S41A family
C6Y50_RS05965	COG2861	carbohydrate metabolic process
C6Y50_RS05980	COG0107	imidazoleglycerol-phosphate synthase activity
C6Y50_RS05985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C6Y50_RS06000	COG0131	Imidazoleglycerol-phosphate dehydratase
C6Y50_RS06005	COG3707	response regulator
C6Y50_RS06010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS06020	COG1116	anion transmembrane transporter activity
C6Y50_RS06035	COG1194	a g-specific adenine glycosylase
C6Y50_RS06040	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C6Y50_RS06050	COG1525	nuclease
C6Y50_RS06085	COG0676	glucose-6-phosphate 1-epimerase activity
C6Y50_RS06105	COG0840	transmembrane signaling receptor activity
C6Y50_RS06120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C6Y50_RS06140	COG3052	prosthetic group binding
C6Y50_RS06145	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
C6Y50_RS06155	COG4221	oxidoreductase activity
C6Y50_RS06160	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C6Y50_RS06175	COG2358	TRAP transporter, solute receptor (TAXI family
C6Y50_RS06215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y50_RS06225	COG3360	Dodecin
C6Y50_RS06230	COG0625	glutathione transferase activity
C6Y50_RS06250	COG0737	Belongs to the 5'-nucleotidase family
C6Y50_RS06250	COG1525	nuclease
C6Y50_RS06250	COG4085	toxin activity
C6Y50_RS06265	COG3340	Belongs to the peptidase S51 family
C6Y50_RS06270	COG1132	(ABC) transporter
C6Y50_RS06285	COG1196	nuclear chromosome segregation
C6Y50_RS06295	COG2323	membrane
C6Y50_RS06300	COG0583	DNA-binding transcription factor activity
C6Y50_RS06330	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C6Y50_RS06335	COG0339	signal peptide processing
C6Y50_RS06365	COG0659	secondary active sulfate transmembrane transporter activity
C6Y50_RS06375	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6Y50_RS06380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6Y50_RS06385	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
C6Y50_RS06415	COG0109	protoheme IX farnesyltransferase activity
C6Y50_RS06440	COG1595	DNA-templated transcription, initiation
C6Y50_RS06455	COG0523	cobalamin synthesis protein
C6Y50_RS06470	COG4251	negative regulation of phosphorylation
C6Y50_RS06475	COG0784	Response regulator, receiver
C6Y50_RS06490	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C6Y50_RS06495	COG1349	DNA-binding transcription factor activity
C6Y50_RS06505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6Y50_RS06510	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C6Y50_RS06515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C6Y50_RS06520	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C6Y50_RS06525	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C6Y50_RS06530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C6Y50_RS06535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C6Y50_RS06545	COG0356	it plays a direct role in the translocation of protons across the membrane
C6Y50_RS06555	COG1475	DNA binding
C6Y50_RS06560	COG1192	Involved in chromosome partitioning
C6Y50_RS06565	COG0357	Ribosomal RNA small subunit methyltransferase G
C6Y50_RS06570	COG0445	tRNA wobble uridine modification
C6Y50_RS06575	COG1320	monovalent cation:proton antiporter activity
C6Y50_RS06590	COG0651	ATP synthesis coupled electron transport
C6Y50_RS06595	COG1006	Multisubunit Na H antiporter MnhC subunit
C6Y50_RS06600	COG2111	Na H antiporter
C6Y50_RS06605	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6Y50_RS06605	COG2111	Na H antiporter
C6Y50_RS06610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C6Y50_RS06615	COG0706	membrane insertase activity
C6Y50_RS06620	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C6Y50_RS06625	COG0594	ribonuclease P activity
C6Y50_RS06630	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C6Y50_RS06635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C6Y50_RS06645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C6Y50_RS06655	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y50_RS06680	COG0464	growth
C6Y50_RS06755	COG3706	GGDEF domain
C6Y50_RS06770	COG0751	glycine-tRNA ligase activity
C6Y50_RS06780	COG2818	Glycosylase
C6Y50_RS06800	COG1126	abc transporter atp-binding protein
C6Y50_RS06805	COG0765	amino acid transport
C6Y50_RS06810	COG0765	amino acid transport
C6Y50_RS06815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y50_RS06820	COG0569	domain protein
C6Y50_RS06825	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C6Y50_RS06830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C6Y50_RS06835	COG0242	peptide deformylase activity
C6Y50_RS06845	COG0758	DNA mediated transformation
C6Y50_RS06850	COG0009	L-threonylcarbamoyladenylate synthase
C6Y50_RS06860	COG0408	coproporphyrinogen oxidase activity
C6Y50_RS06865	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C6Y50_RS06880	COG1686	Belongs to the peptidase S11 family
C6Y50_RS06920	COG2011	ABC-type metal ion transport system permease component
C6Y50_RS06935	COG1451	nucleotide metabolic process
C6Y50_RS06940	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C6Y50_RS06945	COG1121	(ABC) transporter
C6Y50_RS06950	COG0735	belongs to the Fur family
C6Y50_RS06960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C6Y50_RS06965	COG1012	belongs to the aldehyde dehydrogenase family
C6Y50_RS06985	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS06990	COG5002	protein histidine kinase activity
C6Y50_RS07000	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS07005	COG5002	protein histidine kinase activity
C6Y50_RS07010	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS07015	COG4191	Histidine kinase
C6Y50_RS07025	COG3706	GGDEF domain
C6Y50_RS07035	COG2957	Belongs to the agmatine deiminase family
C6Y50_RS07050	COG0174	glutamine synthetase
C6Y50_RS07055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C6Y50_RS07060	COG0174	glutamine synthetase
C6Y50_RS07085	COG3842	ATPase activity
C6Y50_RS07090	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y50_RS07095	COG1177	transmembrane transport
C6Y50_RS07105	COG0596	Alpha beta hydrolase
C6Y50_RS07165	COG0842	Transport permease protein
C6Y50_RS07170	COG0842	Transport permease protein
C6Y50_RS07170	COG1129	ABC transporter
C6Y50_RS07175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y50_RS07190	COG1127	ABC transporter
C6Y50_RS07195	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6Y50_RS07200	COG0753	catalase activity
C6Y50_RS07205	COG2010	Cytochrome c
C6Y50_RS07215	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
C6Y50_RS07220	COG3909	cytochrome
C6Y50_RS07225	COG1012	belongs to the aldehyde dehydrogenase family
C6Y50_RS07235	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y50_RS07235	COG1024	Enoyl-CoA hydratase
C6Y50_RS07240	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS07250	COG2814	Major facilitator Superfamily
C6Y50_RS07270	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS07275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C6Y50_RS07280	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C6Y50_RS07295	COG1611	Belongs to the LOG family
C6Y50_RS07340	COG2207	Transcriptional regulator
C6Y50_RS07350	COG2249	NAD(P)H dehydrogenase (quinone) activity
C6Y50_RS07420	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C6Y50_RS07425	COG0583	DNA-binding transcription factor activity
C6Y50_RS07465	COG2706	6-phosphogluconolactonase activity
C6Y50_RS07470	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS07475	COG4191	Histidine kinase
C6Y50_RS07475	COG0784	Response regulator, receiver
C6Y50_RS07500	COG3795	YCII-related domain
C6Y50_RS07505	COG4941	Belongs to the sigma-70 factor family
C6Y50_RS07510	COG2204	response regulator
C6Y50_RS07515	COG4191	Histidine kinase
C6Y50_RS07525	COG0589	response to stress
C6Y50_RS07530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y50_RS07540	COG0509	glycine decarboxylation via glycine cleavage system
C6Y50_RS07555	COG3276	selenocysteine insertion sequence binding
C6Y50_RS07560	COG1921	L-seryl-tRNASec selenium transferase activity
C6Y50_RS07565	COG3058	Necessary for formate dehydrogenase activity
C6Y50_RS07570	COG2864	formate dehydrogenase
C6Y50_RS07575	COG0437	4 iron, 4 sulfur cluster binding
C6Y50_RS07590	COG1764	response to oxidative stress
C6Y50_RS07605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6Y50_RS07610	COG0210	DNA helicase
C6Y50_RS07620	COG0826	peptidase U32
C6Y50_RS07625	COG2841	Protein conserved in bacteria
C6Y50_RS07630	COG0527	aspartate kinase activity
C6Y50_RS07635	COG5285	phytanoyl-CoA dioxygenase
C6Y50_RS07640	COG1917	Cupin 2, conserved barrel domain protein
C6Y50_RS07645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6Y50_RS07655	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C6Y50_RS07660	COG1737	Transcriptional regulator
C6Y50_RS07660	COG0837	glucose binding
C6Y50_RS07670	COG0583	DNA-binding transcription factor activity
C6Y50_RS07675	COG0439	Biotin carboxylase
C6Y50_RS07680	COG0511	ligase activity, forming carbon-carbon bonds
C6Y50_RS07680	COG5016	pyruvate
C6Y50_RS07695	COG2066	Belongs to the glutaminase family
C6Y50_RS07710	COG0252	asparaginase activity
C6Y50_RS07715	COG1115	amino acid carrier protein
C6Y50_RS07725	COG1301	dicarboxylic acid transport
C6Y50_RS07735	COG0583	DNA-binding transcription factor activity
C6Y50_RS07740	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS07745	COG3185	4-Hydroxyphenylpyruvate dioxygenase
C6Y50_RS07745	COG1082	Xylose isomerase domain protein TIM barrel
C6Y50_RS07750	COG2205	protein histidine kinase activity
C6Y50_RS07780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y50_RS07790	COG4208	sulfate ABC transporter
C6Y50_RS07800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C6Y50_RS07805	COG5583	Uncharacterized small protein (DUF2292)
C6Y50_RS07815	COG3829	transcription factor binding
C6Y50_RS07820	COG2175	clavaminate synthase activity
C6Y50_RS07835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y50_RS07850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS07860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS07865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y50_RS07875	COG0450	alkyl hydroperoxide reductase
C6Y50_RS07880	COG0431	NADPH-dependent FMN reductase
C6Y50_RS07885	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS07890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y50_RS07895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y50_RS07900	COG1116	anion transmembrane transporter activity
C6Y50_RS07925	COG0583	DNA-binding transcription factor activity
C6Y50_RS07930	COG2814	Major facilitator Superfamily
C6Y50_RS07955	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C6Y50_RS07960	COG1764	response to oxidative stress
C6Y50_RS07975	COG2989	Protein conserved in bacteria
C6Y50_RS07985	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C6Y50_RS07995	COG1392	Phosphate transport regulator
C6Y50_RS08000	COG0306	phosphate transporter
C6Y50_RS08020	COG2918	glutathione biosynthetic process
C6Y50_RS08030	COG2183	response to ionizing radiation
C6Y50_RS08035	COG3118	belongs to the thioredoxin family
C6Y50_RS08035	COG0457	Tetratricopeptide repeat
C6Y50_RS08040	COG1215	transferase activity, transferring glycosyl groups
C6Y50_RS08045	COG1215	transferase activity, transferring glycosyl groups
C6Y50_RS08050	COG1192	Involved in chromosome partitioning
C6Y50_RS08060	COG2194	sulfuric ester hydrolase activity
C6Y50_RS08090	COG0189	ligase activity
C6Y50_RS08095	COG0189	ligase activity
C6Y50_RS08095	COG4067	protein conserved in archaea
C6Y50_RS08100	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C6Y50_RS08110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C6Y50_RS08120	COG0778	Nitroreductase
C6Y50_RS08130	COG0514	ATP-dependent DNA helicase (RecQ)
C6Y50_RS08135	COG0840	transmembrane signaling receptor activity
C6Y50_RS08150	COG0019	diaminopimelate decarboxylase activity
C6Y50_RS08165	COG0747	negative chemotaxis
C6Y50_RS08175	COG0667	Aldo Keto reductase
C6Y50_RS08200	COG0784	Response regulator, receiver
C6Y50_RS08200	COG4191	Histidine kinase
C6Y50_RS08205	COG2205	protein histidine kinase activity
C6Y50_RS08215	COG2172	sigma factor antagonist activity
C6Y50_RS08220	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y50_RS08225	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y50_RS08235	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y50_RS08235	COG1024	Enoyl-CoA hydratase
C6Y50_RS08240	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS08245	COG1454	alcohol dehydrogenase
C6Y50_RS08260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6Y50_RS08265	COG4191	Histidine kinase
C6Y50_RS08265	COG0784	Response regulator, receiver
C6Y50_RS08270	COG1011	Hydrolase
C6Y50_RS08275	COG0494	nUDIX hydrolase
C6Y50_RS08280	COG1218	3'(2'),5'-bisphosphate nucleotidase
C6Y50_RS08295	COG0058	SHG alpha-glucan phosphorylase activity
C6Y50_RS08300	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
C6Y50_RS08330	COG1490	D-aminoacyl-tRNA deacylase activity
C6Y50_RS08350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y50_RS08355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C6Y50_RS08360	COG0140	phosphoribosyl-ATP diphosphatase activity
C6Y50_RS08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C6Y50_RS08370	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C6Y50_RS08380	COG2226	methyltransferase
C6Y50_RS08390	COG0840	transmembrane signaling receptor activity
C6Y50_RS08400	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C6Y50_RS08410	COG0243	molybdopterin cofactor binding
C6Y50_RS08430	COG3852	Histidine kinase
C6Y50_RS08450	COG0301	tRNA thio-modification
C6Y50_RS08450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6Y50_RS08455	COG1217	gtp-binding protein TYPA
C6Y50_RS08465	COG3493	citrate carrier protein
C6Y50_RS08470	COG3290	protein histidine kinase activity
C6Y50_RS08475	COG4565	transcriptional regulatory protein
C6Y50_RS08500	COG2204	response regulator
C6Y50_RS08505	COG4807	Protein conserved in bacteria
C6Y50_RS08530	COG5001	Diguanylate cyclase
C6Y50_RS08535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
C6Y50_RS08545	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS08550	COG0003	Pfam Anion-transporting ATPase
C6Y50_RS08560	COG1966	Carbon starvation protein
C6Y50_RS08575	COG1320	monovalent cation:proton antiporter activity
C6Y50_RS08595	COG0651	ATP synthesis coupled electron transport
C6Y50_RS08600	COG0651	ATP synthesis coupled electron transport
C6Y50_RS08640	COG2197	response regulator
C6Y50_RS08665	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y50_RS08670	COG0277	FAD linked oxidase domain protein
C6Y50_RS08675	COG0179	Fumarylacetoacetate (FAA) hydrolase
C6Y50_RS08695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C6Y50_RS08700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C6Y50_RS08720	COG0494	nUDIX hydrolase
C6Y50_RS08735	COG0730	response to heat
C6Y50_RS08740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C6Y50_RS08745	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
C6Y50_RS08750	COG1192	Involved in chromosome partitioning
C6Y50_RS08760	COG0559	Belongs to the binding-protein-dependent transport system permease family
C6Y50_RS08770	COG0411	ABC transporter
C6Y50_RS08790	COG0739	heme binding
C6Y50_RS08800	COG1253	flavin adenine dinucleotide binding
C6Y50_RS08815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C6Y50_RS08820	COG3161	chorismate lyase activity
C6Y50_RS08825	COG2186	Transcriptional regulator
C6Y50_RS08830	COG0277	FAD linked oxidase domain protein
C6Y50_RS08835	COG0277	FAD linked oxidase domain protein
C6Y50_RS08840	COG0247	lactate metabolic process
C6Y50_RS08845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
C6Y50_RS08850	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
C6Y50_RS08855	COG1620	l-lactate permease
C6Y50_RS08880	COG0583	DNA-binding transcription factor activity
C6Y50_RS08885	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS08895	COG0604	alcohol dehydrogenase
C6Y50_RS08900	COG0583	DNA-binding transcription factor activity
C6Y50_RS08905	COG1704	LemA family
C6Y50_RS08910	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C6Y50_RS08930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y50_RS08950	COG2080	2 iron, 2 sulfur cluster binding
C6Y50_RS08970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6Y50_RS08975	COG1758	RNA polymerase activity
C6Y50_RS08985	COG1561	YicC-like family, N-terminal region
C6Y50_RS08990	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C6Y50_RS09000	COG0708	Exodeoxyribonuclease III
C6Y50_RS09005	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C6Y50_RS09020	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C6Y50_RS09030	COG0756	dUTP diphosphatase activity
C6Y50_RS09035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C6Y50_RS09040	COG2003	Belongs to the UPF0758 family
C6Y50_RS09055	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y50_RS09075	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y50_RS09080	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y50_RS09090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y50_RS09095	COG0251	oxidation-reduction process
C6Y50_RS09115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6Y50_RS09130	COG0366	Alpha amylase catalytic
C6Y50_RS09135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6Y50_RS09145	COG1454	alcohol dehydrogenase
C6Y50_RS09155	COG1414	Transcriptional regulator
C6Y50_RS09160	COG1272	protein, Hemolysin III
C6Y50_RS09165	COG0210	DNA helicase
C6Y50_RS09175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6Y50_RS09180	COG0606	chelatase, subunit chli
C6Y50_RS09190	COG0347	Belongs to the P(II) protein family
C6Y50_RS09195	COG0004	ammonium transporteR
C6Y50_RS09200	COG0004	ammonium transporteR
C6Y50_RS09205	COG0432	Pfam Uncharacterised protein family UPF0047
C6Y50_RS09220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
C6Y50_RS09230	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C6Y50_RS09245	COG1965	Belongs to the frataxin family
C6Y50_RS09250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C6Y50_RS09290	COG0165	Argininosuccinate lyase
C6Y50_RS09300	COG3275	phosphorelay sensor kinase activity
C6Y50_RS09310	COG0181	hydroxymethylbilane synthase activity
C6Y50_RS09330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C6Y50_RS09350	COG0488	(ABC) transporter
C6Y50_RS09360	COG0861	Integral membrane protein TerC family
C6Y50_RS09365	COG1280	lysine exporter protein (LysE YggA)
C6Y50_RS09370	COG1671	Belongs to the UPF0178 family
C6Y50_RS09385	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
C6Y50_RS09395	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C6Y50_RS09400	COG0248	Ppx GppA phosphatase
C6Y50_RS09415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C6Y50_RS09430	COG0018	arginyl-trna synthetase
C6Y50_RS09435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C6Y50_RS09440	COG0254	rRNA binding
C6Y50_RS09450	COG0281	malic enzyme
C6Y50_RS09485	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C6Y50_RS09490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C6Y50_RS09500	COG0069	glutamate synthase activity
C6Y50_RS09500	COG0067	glutamate synthase
C6Y50_RS09500	COG0070	glutamate synthase
C6Y50_RS09505	COG0493	'glutamate synthase
C6Y50_RS09515	COG2814	Major facilitator Superfamily
C6Y50_RS09520	COG0583	DNA-binding transcription factor activity
C6Y50_RS09535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y50_RS09540	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS09580	COG2986	histidine ammonia-lyase
C6Y50_RS09605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y50_RS09610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y50_RS09625	COG3118	belongs to the thioredoxin family
C6Y50_RS09630	COG2873	o-acetylhomoserine
C6Y50_RS09635	COG0471	metal ion transport
C6Y50_RS09635	COG3273	potassium ion transport
C6Y50_RS09660	COG3328	transposase activity
C6Y50_RS09705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C6Y50_RS09790	COG3328	transposase activity
C6Y50_RS09825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C6Y50_RS09830	COG0358	DNA primase activity
C6Y50_RS09835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
C6Y50_RS09840	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C6Y50_RS09845	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C6Y50_RS09860	COG0617	tRNA 3'-terminal CCA addition
C6Y50_RS09865	COG2719	SpoVR family
C6Y50_RS09870	COG2718	Belongs to the UPF0229 family
C6Y50_RS09875	COG2766	serine protein kinase
C6Y50_RS09880	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C6Y50_RS09885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6Y50_RS09890	COG2967	ApaG domain
C6Y50_RS09895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C6Y50_RS09900	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C6Y50_RS09905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y50_RS09910	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C6Y50_RS09920	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C6Y50_RS09925	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C6Y50_RS09940	COG2197	response regulator
C6Y50_RS09945	COG3842	ATPase activity
C6Y50_RS09955	COG1176	ABC-type spermidine putrescine transport system, permease component I
C6Y50_RS09960	COG1177	transmembrane transport
C6Y50_RS09970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C6Y50_RS09975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C6Y50_RS09980	COG0546	phosphoglycolate phosphatase activity
C6Y50_RS09990	COG0512	Glutamine amidotransferase of anthranilate synthase
C6Y50_RS09995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6Y50_RS10000	COG0134	indole-3-glycerol-phosphate synthase activity
C6Y50_RS10010	COG1765	OsmC-like protein
C6Y50_RS10015	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
C6Y50_RS10020	COG0537	adenosine 5'-monophosphoramidase activity
C6Y50_RS10025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y50_RS10035	COG1981	membrane
C6Y50_RS10040	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C6Y50_RS10045	COG0316	Belongs to the HesB IscA family
C6Y50_RS10050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
C6Y50_RS10055	COG0739	heme binding
C6Y50_RS10060	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C6Y50_RS10095	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C6Y50_RS10095	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C6Y50_RS10100	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C6Y50_RS10125	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y50_RS10145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C6Y50_RS10150	COG0081	regulation of translation
C6Y50_RS10155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C6Y50_RS10160	COG0222	ribosome binding
C6Y50_RS10165	COG0085	RNA polymerase activity
C6Y50_RS10170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C6Y50_RS10175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C6Y50_RS10180	COG0049	tRNA binding
C6Y50_RS10185	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C6Y50_RS10190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C6Y50_RS10195	COG0051	transcription antitermination factor activity, RNA binding
C6Y50_RS10200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C6Y50_RS10205	COG0088	Forms part of the polypeptide exit tunnel
C6Y50_RS10210	COG0089	rRNA binding
C6Y50_RS10215	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C6Y50_RS10220	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C6Y50_RS10225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C6Y50_RS10230	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C6Y50_RS10235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C6Y50_RS10240	COG0255	Belongs to the universal ribosomal protein uL29 family
C6Y50_RS10245	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C6Y50_RS10250	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C6Y50_RS10255	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C6Y50_RS10260	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C6Y50_RS10265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C6Y50_RS10270	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C6Y50_RS10275	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C6Y50_RS10285	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C6Y50_RS10290	COG1841	ribosomal large subunit assembly
C6Y50_RS10295	COG0200	Binds to the 23S rRNA
C6Y50_RS10305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C6Y50_RS10310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C6Y50_RS10315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C6Y50_RS10320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C6Y50_RS10325	COG0202	RNA polymerase activity
C6Y50_RS10330	COG0203	ribosomal protein L17
C6Y50_RS10345	COG2814	Major facilitator Superfamily
C6Y50_RS10365	COG3047	cAMP biosynthetic process
C6Y50_RS10375	COG0811	peptide transport
C6Y50_RS10380	COG0811	peptide transport
C6Y50_RS10385	COG0848	biopolymer transport protein
C6Y50_RS10410	COG4181	ATPase activity
C6Y50_RS10425	COG3118	belongs to the thioredoxin family
C6Y50_RS10430	COG2391	methyltransferase activity
C6Y50_RS10435	COG0425	Belongs to the sulfur carrier protein TusA family
C6Y50_RS10445	COG2264	protein methyltransferase activity
C6Y50_RS10460	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y50_RS10460	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C6Y50_RS10475	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C6Y50_RS10480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C6Y50_RS10490	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C6Y50_RS10495	COG3577	Aspartyl protease
C6Y50_RS10500	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C6Y50_RS10515	COG4206	TonB-dependent receptor
C6Y50_RS10525	COG0420	3'-5' exonuclease activity
C6Y50_RS10585	COG1040	competence protein
C6Y50_RS10590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C6Y50_RS10595	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS10600	COG2610	gluconate transmembrane transporter activity
C6Y50_RS10605	COG2031	fatty acid transporter
C6Y50_RS10615	COG1522	sequence-specific DNA binding
C6Y50_RS10630	COG0733	neurotransmitter:sodium symporter activity
C6Y50_RS10640	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
C6Y50_RS10650	COG0625	glutathione transferase activity
C6Y50_RS10655	COG0733	neurotransmitter:sodium symporter activity
C6Y50_RS10675	COG4651	solute:proton antiporter activity
C6Y50_RS10675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6Y50_RS10680	COG0513	Belongs to the DEAD box helicase family
C6Y50_RS10710	COG0123	including yeast histone deacetylase and acetoin utilization protein
C6Y50_RS10720	COG1946	Acyl-CoA thioesterase
C6Y50_RS10730	COG2321	neutral zinc metallopeptidase
C6Y50_RS10755	COG2197	response regulator
C6Y50_RS10760	COG3850	Histidine kinase
C6Y50_RS10765	COG2223	nitrite transmembrane transporter activity
C6Y50_RS10775	COG2223	nitrite transmembrane transporter activity
C6Y50_RS10780	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C6Y50_RS10785	COG1140	nitrate reductase beta subunit
C6Y50_RS10790	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C6Y50_RS10795	COG2181	nitrate reductase activity
C6Y50_RS10810	COG0521	Mo-molybdopterin cofactor biosynthetic process
C6Y50_RS10820	COG3038	cytochrome b561
C6Y50_RS10850	COG1022	Amp-dependent synthetase and ligase
C6Y50_RS10875	COG1368	sulfuric ester hydrolase activity
C6Y50_RS10885	COG0642	Histidine kinase
C6Y50_RS10895	COG3642	lipopolysaccharide core region biosynthetic process
C6Y50_RS10905	COG1368	sulfuric ester hydrolase activity
C6Y50_RS10910	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6Y50_RS10915	COG2252	PERMEase
C6Y50_RS10925	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C6Y50_RS10925	COG3608	succinylglutamate desuccinylase aspartoacylase
C6Y50_RS10930	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C6Y50_RS10935	COG2080	2 iron, 2 sulfur cluster binding
C6Y50_RS10940	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C6Y50_RS10945	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C6Y50_RS10975	COG0789	Transcriptional regulator
C6Y50_RS10980	COG2813	Specifically methylates the guanine in position
C6Y50_RS11015	COG0488	(ABC) transporter
C6Y50_RS11025	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C6Y50_RS11030	COG2020	methyltransferase activity
C6Y50_RS11050	COG2841	Protein conserved in bacteria
C6Y50_RS11055	COG1970	mechanosensitive ion channel activity
C6Y50_RS11065	COG1067	ATP-dependent peptidase activity
C6Y50_RS11075	COG2862	Uncharacterized protein family, UPF0114
C6Y50_RS11085	COG3046	protein related to deoxyribodipyrimidine photolyase
C6Y50_RS11095	COG0545	Peptidyl-prolyl cis-trans isomerase
C6Y50_RS11105	COG0142	geranyltranstransferase activity
C6Y50_RS11110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C6Y50_RS11115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C6Y50_RS11120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C6Y50_RS11125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C6Y50_RS11130	COG3045	CreA protein
C6Y50_RS11135	COG0268	Binds directly to 16S ribosomal RNA
C6Y50_RS11140	COG0728	peptidoglycan biosynthetic process
C6Y50_RS11145	COG0196	riboflavin kinase activity
C6Y50_RS11150	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C6Y50_RS11155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C6Y50_RS11160	COG1047	Peptidyl-prolyl cis-trans
C6Y50_RS11165	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C6Y50_RS11200	COG4968	Prepilin-type N-terminal cleavage methylation domain
C6Y50_RS11205	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y50_RS11210	COG0023	Translation Initiation Factor
C6Y50_RS11225	COG0534	Mate efflux family protein
C6Y50_RS11255	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y50_RS11270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6Y50_RS11270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C6Y50_RS11275	COG1105	Belongs to the carbohydrate kinase PfkB family
C6Y50_RS11280	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6Y50_RS11280	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
C6Y50_RS11280	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C6Y50_RS11285	COG4993	Dehydrogenase
C6Y50_RS11290	COG2852	Protein conserved in bacteria
C6Y50_RS11295	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C6Y50_RS11300	COG0019	diaminopimelate decarboxylase activity
C6Y50_RS11310	COG3128	pkhd-type hydroxylase
C6Y50_RS11315	COG4774	siderophore transport
C6Y50_RS11320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C6Y50_RS11340	COG4771	TonB-dependent receptor
C6Y50_RS11355	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C6Y50_RS11365	COG0739	heme binding
C6Y50_RS11380	COG0530	calcium, potassium:sodium antiporter activity
C6Y50_RS11395	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y50_RS11405	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C6Y50_RS11410	COG1077	Cell shape determining protein MreB Mrl
C6Y50_RS11415	COG1792	Involved in formation and maintenance of cell shape
C6Y50_RS11435	COG1530	ribonuclease E activity
C6Y50_RS11445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y50_RS11450	COG0312	modulator of DNA gyrase
C6Y50_RS11460	COG0312	modulator of DNA gyrase
C6Y50_RS11465	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C6Y50_RS11470	COG1660	Displays ATPase and GTPase activities
C6Y50_RS11485	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C6Y50_RS11490	COG1137	ATPase activity
C6Y50_RS11505	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
C6Y50_RS11515	COG1127	ABC transporter
C6Y50_RS11520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C6Y50_RS11525	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
C6Y50_RS11550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C6Y50_RS11555	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C6Y50_RS11565	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C6Y50_RS11570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y50_RS11580	COG0175	sulfate reduction
C6Y50_RS11605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C6Y50_RS11610	COG0237	dephospho-CoA kinase activity
C6Y50_RS11625	COG0667	Aldo Keto reductase
C6Y50_RS11630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C6Y50_RS11635	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C6Y50_RS11640	COG0723	plastoquinol--plastocyanin reductase activity
C6Y50_RS11645	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C6Y50_RS11650	COG2857	Cytochrome c1
C6Y50_RS11670	COG2969	positive regulation of protein catabolic process
C6Y50_RS11675	COG2823	Periplasmic or secreted lipoprotein
C6Y50_RS11680	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C6Y50_RS11685	COG0792	nuclease activity
C6Y50_RS11710	COG0275	rRNA processing
C6Y50_RS11725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y50_RS11730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C6Y50_RS11735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C6Y50_RS11740	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C6Y50_RS11745	COG0772	Belongs to the SEDS family
C6Y50_RS11750	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C6Y50_RS11755	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C6Y50_RS11760	COG1181	Belongs to the D-alanine--D-alanine ligase family
C6Y50_RS11805	COG1285	pathogenesis
C6Y50_RS11830	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS11835	COG0659	secondary active sulfate transmembrane transporter activity
C6Y50_RS11890	COG0840	transmembrane signaling receptor activity
C6Y50_RS11895	COG0501	Belongs to the peptidase M48B family
C6Y50_RS11905	COG2119	membrane
C6Y50_RS11910	COG2813	Specifically methylates the guanine in position
C6Y50_RS11915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C6Y50_RS11920	COG1280	lysine exporter protein (LysE YggA)
C6Y50_RS11925	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS11930	COG4191	Histidine kinase
C6Y50_RS11930	COG0784	Response regulator, receiver
C6Y50_RS11935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y50_RS11940	COG2885	chlorophyll binding
C6Y50_RS11945	COG0784	Response regulator, receiver
C6Y50_RS11945	COG2205	protein histidine kinase activity
C6Y50_RS11955	COG0204	Acyl-transferase
C6Y50_RS11965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C6Y50_RS11975	COG0386	Belongs to the glutathione peroxidase family
C6Y50_RS11980	COG1309	transcriptional regulator
C6Y50_RS11990	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
C6Y50_RS12005	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6Y50_RS12010	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS12050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y50_RS12055	COG0693	protein deglycase activity
C6Y50_RS12060	COG4628	conserved protein (DUF2132)
C6Y50_RS12080	COG0469	pyruvate kinase activity
C6Y50_RS12105	COG0714	Associated with various cellular activities
C6Y50_RS12130	COG2925	Exonuclease
C6Y50_RS12140	COG0788	formyltetrahydrofolate deformylase activity
C6Y50_RS12150	COG0433	COG0433 Predicted ATPase
C6Y50_RS12165	COG3022	response to hydroperoxide
C6Y50_RS12170	COG1230	cation diffusion facilitator family transporter
C6Y50_RS12175	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C6Y50_RS12180	COG0315	cyclic pyranopterin monophosphate synthase activity
C6Y50_RS12185	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C6Y50_RS12200	COG0400	carboxylic ester hydrolase activity
C6Y50_RS12205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C6Y50_RS12210	COG4597	amino acid ABC transporter
C6Y50_RS12220	COG0765	amino acid transport
C6Y50_RS12225	COG1126	abc transporter atp-binding protein
C6Y50_RS12230	COG0047	phosphoribosylformylglycinamidine synthase activity
C6Y50_RS12230	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C6Y50_RS12240	COG3034	peptidoglycan biosynthetic process
C6Y50_RS12265	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C6Y50_RS12270	COG4536	flavin adenine dinucleotide binding
C6Y50_RS12275	COG4137	Cytochrome C assembly protein
C6Y50_RS12280	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C6Y50_RS12285	COG0228	four-way junction DNA binding
C6Y50_RS12290	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C6Y50_RS12295	COG0336	Belongs to the RNA methyltransferase TrmD family
C6Y50_RS12300	COG0335	large ribosomal subunit rRNA binding
C6Y50_RS12315	COG3791	Glutathione-dependent formaldehyde-activating
C6Y50_RS12330	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y50_RS12335	COG0418	dihydroorotase activity
C6Y50_RS12345	COG0137	argininosuccinate synthase activity
C6Y50_RS12350	COG0346	lactoylglutathione lyase activity
C6Y50_RS12360	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C6Y50_RS12370	COG4659	FMN binding
C6Y50_RS12375	COG4658	electron transport chain
C6Y50_RS12385	COG2878	Part of a membrane complex involved in electron transport
C6Y50_RS12390	COG4657	Part of a membrane complex involved in electron transport
C6Y50_RS12405	COG1024	Enoyl-CoA hydratase
C6Y50_RS12415	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C6Y50_RS12430	COG0354	folic acid binding
C6Y50_RS12470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y50_RS12475	COG0481	GTPase activity
C6Y50_RS12490	COG0571	ribonuclease III activity
C6Y50_RS12500	COG1381	Involved in DNA repair and RecF pathway recombination
C6Y50_RS12505	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
C6Y50_RS12515	COG0583	DNA-binding transcription factor activity
C6Y50_RS12525	COG0500	methyltransferase
C6Y50_RS12530	COG2226	methyltransferase
C6Y50_RS12540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6Y50_RS12555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y50_RS12570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y50_RS12580	COG0583	DNA-binding transcription factor activity
C6Y50_RS12585	COG3485	protocatechuate 3,4-dioxygenase
C6Y50_RS12590	COG3485	protocatechuate 3,4-dioxygenase
C6Y50_RS12595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y50_RS12600	COG0679	Auxin Efflux Carrier
C6Y50_RS12605	COG1414	Transcriptional regulator
C6Y50_RS12610	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C6Y50_RS12615	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C6Y50_RS12630	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y50_RS12635	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C6Y50_RS12640	COG3609	addiction module antidote protein, CC2985 family
C6Y50_RS12690	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
C6Y50_RS12700	COG0583	DNA-binding transcription factor activity
C6Y50_RS12705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C6Y50_RS12710	COG0501	Belongs to the peptidase M48B family
C6Y50_RS12730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C6Y50_RS12740	COG0542	response to heat
C6Y50_RS12745	COG0071	Belongs to the small heat shock protein (HSP20) family
C6Y50_RS12765	COG0583	DNA-binding transcription factor activity
C6Y50_RS12780	COG1192	Involved in chromosome partitioning
C6Y50_RS12825	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C6Y50_RS13030	COG1063	alcohol dehydrogenase
C6Y50_RS13130	COG2003	Belongs to the UPF0758 family
C6Y50_RS13205	COG0582	viral genome integration into host DNA
C6Y50_RS13225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y50_RS13225	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C6Y50_RS13230	COG0489	protein tyrosine kinase activity
C6Y50_RS13235	COG1278	Cold shock
C6Y50_RS13240	COG0717	Belongs to the dCTP deaminase family
C6Y50_RS13245	COG3005	denitrification pathway
C6Y50_RS13255	COG0243	molybdopterin cofactor binding
C6Y50_RS13265	COG4459	periplasmic nitrate reductase
C6Y50_RS13270	COG2814	Major facilitator Superfamily
C6Y50_RS13295	COG0037	tRNA processing
C6Y50_RS13300	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6Y50_RS13305	COG2818	Glycosylase
C6Y50_RS13330	COG1294	oxidase, subunit
C6Y50_RS13335	COG4890	Cyd operon protein YbgT
C6Y50_RS13350	COG0791	NLP P60 protein
C6Y50_RS13355	COG0791	NLP P60 protein
C6Y50_RS13370	COG4206	TonB-dependent receptor
C6Y50_RS13385	COG1797	cobyrinic acid a,c-diamide synthase activity
C6Y50_RS13390	COG0778	Nitroreductase
C6Y50_RS13400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
C6Y50_RS13410	COG1492	cobalamin metabolic process
C6Y50_RS13430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
C6Y50_RS13440	COG0251	oxidation-reduction process
C6Y50_RS13465	COG2067	long-chain fatty acid transport protein
C6Y50_RS13480	COG3100	YcgL domain-containing protein
C6Y50_RS13490	COG2983	Belongs to the UPF0260 family
C6Y50_RS13505	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C6Y50_RS13510	COG0527	aspartate kinase activity
C6Y50_RS13515	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C6Y50_RS13540	COG2239	Acts as a magnesium transporter
C6Y50_RS13545	COG3630	sodium ion export across plasma membrane
C6Y50_RS13550	COG0511	ligase activity, forming carbon-carbon bonds
C6Y50_RS13550	COG5016	pyruvate
C6Y50_RS13555	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
C6Y50_RS13580	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C6Y50_RS13600	COG0835	chemotaxis
C6Y50_RS13600	COG0784	Response regulator, receiver
C6Y50_RS13605	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C6Y50_RS13610	COG1815	bacterial-type flagellum-dependent cell motility
C6Y50_RS13630	COG4787	bacterial-type flagellum-dependent cell motility
C6Y50_RS13635	COG4786	Flagellar basal body rod
C6Y50_RS13640	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
C6Y50_RS13645	COG1706	bacterial-type flagellum-dependent cell motility
C6Y50_RS13655	COG1256	bacterial-type flagellum assembly
C6Y50_RS13665	COG1555	photosystem II stabilization
C6Y50_RS13690	COG2200	EAL domain
C6Y50_RS13705	COG1362	aminopeptidase activity
C6Y50_RS13715	COG0564	pseudouridine synthase activity
C6Y50_RS13720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
C6Y50_RS13725	COG2894	cell division
C6Y50_RS13730	COG0850	regulation of cytokinetic process
C6Y50_RS13735	COG1560	Kdo2-lipid A biosynthetic process
C6Y50_RS13745	COG2853	Lipoprotein
C6Y50_RS13760	COG3162	membrane
C6Y50_RS13765	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C6Y50_RS13785	COG3089	Belongs to the UPF0270 family
C6Y50_RS13795	COG1363	Peptidase, m42
C6Y50_RS13800	COG0189	ligase activity
C6Y50_RS13800	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C6Y50_RS13805	COG0367	asparagine synthase
C6Y50_RS13815	COG1404	Belongs to the peptidase S8 family
C6Y50_RS13815	COG4935	Belongs to the peptidase S8 family
C6Y50_RS13825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C6Y50_RS13835	COG4221	oxidoreductase activity
C6Y50_RS13845	COG1201	RNA secondary structure unwinding
C6Y50_RS13880	COG2133	pyrroloquinoline quinone binding
C6Y50_RS13885	COG4993	Dehydrogenase
C6Y50_RS13890	COG2996	Protein conserved in bacteria
C6Y50_RS13905	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C6Y50_RS13995	COG3292	Two component regulator propeller
C6Y50_RS13995	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS13995	COG2205	protein histidine kinase activity
C6Y50_RS14030	COG0784	Response regulator, receiver
C6Y50_RS14030	COG2198	Histidine kinase
C6Y50_RS14030	COG5002	protein histidine kinase activity
C6Y50_RS14070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C6Y50_RS14080	COG1295	ribonuclease BN
C6Y50_RS14085	COG0438	transferase activity, transferring glycosyl groups
C6Y50_RS14105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C6Y50_RS14110	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C6Y50_RS14120	COG1546	Belongs to the CinA family
C6Y50_RS14125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C6Y50_RS14130	COG2137	regulation of response to DNA damage stimulus
C6Y50_RS14140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
C6Y50_RS14145	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C6Y50_RS14155	COG3148	PFAM DTW domain containing protein
C6Y50_RS14160	COG0697	spore germination
C6Y50_RS14170	COG0583	DNA-binding transcription factor activity
C6Y50_RS14180	COG3012	SEC-C Motif Domain Protein
C6Y50_RS14200	COG1199	ATP-dependent helicase activity
C6Y50_RS14205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C6Y50_RS14215	COG0259	pyridoxamine-phosphate oxidase activity
C6Y50_RS14230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C6Y50_RS14230	COG2111	Na H antiporter
C6Y50_RS14235	COG1006	Multisubunit Na H antiporter MnhC subunit
C6Y50_RS14240	COG0651	ATP synthesis coupled electron transport
C6Y50_RS14245	COG1863	multisubunit Na H antiporter MnhE subunit
C6Y50_RS14250	COG2212	antiporter activity
C6Y50_RS14255	COG1320	monovalent cation:proton antiporter activity
C6Y50_RS14260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
C6Y50_RS14265	COG0024	Methionine aminopeptidase
C6Y50_RS14270	COG0052	Belongs to the universal ribosomal protein uS2 family
C6Y50_RS14275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C6Y50_RS14280	COG0528	UMP kinase activity
C6Y50_RS14285	COG0233	cytoplasmic translational termination
C6Y50_RS14290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C6Y50_RS14300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C6Y50_RS14310	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C6Y50_RS14320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y50_RS14325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y50_RS14330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y50_RS14335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y50_RS14340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C6Y50_RS14350	COG0825	malonyl-CoA metabolic process
C6Y50_RS14355	COG0037	tRNA processing
C6Y50_RS14360	COG0504	CTP synthase activity
C6Y50_RS14365	COG2877	3-deoxy-8-phosphooctulonate synthase activity
C6Y50_RS14380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C6Y50_RS14395	COG0583	DNA-binding transcription factor activity
C6Y50_RS14405	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C6Y50_RS14410	COG1902	pentaerythritol trinitrate reductase activity
C6Y50_RS14420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C6Y50_RS14425	COG0585	pseudouridine synthase activity
C6Y50_RS14430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
C6Y50_RS14435	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C6Y50_RS14485	COG0589	response to stress
C6Y50_RS14495	COG0217	transcriptional regulatory protein
C6Y50_RS14505	COG2258	MOSC domain
C6Y50_RS14520	COG0004	ammonium transporteR
C6Y50_RS14570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y50_RS14575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C6Y50_RS14585	COG1283	sodium-dependent phosphate transmembrane transporter activity
C6Y50_RS14600	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C6Y50_RS14655	COG0826	peptidase U32
C6Y50_RS14700	COG2188	Transcriptional regulator
C6Y50_RS14705	COG0789	Transcriptional regulator
C6Y50_RS14710	COG3135	benzoate transporter
C6Y50_RS14715	COG1677	Flagellar hook-basal body complex protein FliE
C6Y50_RS14750	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS14755	COG2198	Histidine kinase
C6Y50_RS14755	COG0643	Histidine kinase
C6Y50_RS14790	COG1987	bacterial-type flagellum assembly
C6Y50_RS14805	COG2032	superoxide dismutase activity
C6Y50_RS14835	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
C6Y50_RS14840	COG2198	Histidine kinase
C6Y50_RS14840	COG0784	Response regulator, receiver
C6Y50_RS14840	COG0643	Histidine kinase
C6Y50_RS14845	COG2201	protein-glutamate methylesterase activity
C6Y50_RS14850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C6Y50_RS14855	COG1360	Flagellar Motor Protein
C6Y50_RS14860	COG1192	Involved in chromosome partitioning
C6Y50_RS14870	COG0835	chemotaxis
C6Y50_RS14885	COG2257	FlhB HrpN YscU SpaS Family
C6Y50_RS14915	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
C6Y50_RS14965	COG0500	methyltransferase
C6Y50_RS14975	COG0501	Belongs to the peptidase M48B family
C6Y50_RS14985	COG0436	Aminotransferase
C6Y50_RS14990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C6Y50_RS14995	COG0386	Belongs to the glutathione peroxidase family
C6Y50_RS15030	COG0640	Transcriptional regulator
C6Y50_RS15060	COG3453	Protein conserved in bacteria
C6Y50_RS15060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y50_RS15070	COG1136	(ABC) transporter
C6Y50_RS15075	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6Y50_RS15100	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
C6Y50_RS15115	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C6Y50_RS15120	COG0471	metal ion transport
C6Y50_RS15125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C6Y50_RS15130	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C6Y50_RS15135	COG0840	transmembrane signaling receptor activity
C6Y50_RS15145	COG0776	regulation of translation
C6Y50_RS15165	COG1086	Polysaccharide biosynthesis protein
C6Y50_RS15170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C6Y50_RS15175	COG1083	cytidylyl-transferase
C6Y50_RS15190	COG2089	acid synthase
C6Y50_RS15205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C6Y50_RS15245	COG2977	Belongs to the P-Pant transferase superfamily
C6Y50_RS15255	COG0183	Belongs to the thiolase family
C6Y50_RS15295	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C6Y50_RS15300	COG3206	protein involved in exopolysaccharide biosynthesis
C6Y50_RS15300	COG0489	protein tyrosine kinase activity
C6Y50_RS15305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6Y50_RS15310	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C6Y50_RS15320	COG3437	response regulator, receiver
C6Y50_RS15325	COG3217	Mosc domain protein beta barrel domain protein
C6Y50_RS15325	COG0633	Ferredoxin
C6Y50_RS15330	COG0741	lytic transglycosylase activity
C6Y50_RS15335	COG0488	(ABC) transporter
C6Y50_RS15345	COG0589	response to stress
C6Y50_RS15355	COG0121	glutamine amidotransferase
C6Y50_RS15375	COG0542	response to heat
C6Y50_RS15385	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C6Y50_RS15395	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
C6Y50_RS15410	COG2832	Protein of unknown function (DUF454)
C6Y50_RS15420	COG0514	ATP-dependent DNA helicase (RecQ)
C6Y50_RS15445	COG2207	Transcriptional regulator
C6Y50_RS15465	COG2354	Protein conserved in bacteria
C6Y50_RS15470	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6Y50_RS15475	COG0727	PFAM Uncharacterised protein family (UPF0153)
C6Y50_RS15480	COG0778	Nitroreductase
C6Y50_RS15495	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS15505	COG2350	Protein conserved in bacteria
C6Y50_RS15510	COG0613	PHP domain protein
C6Y50_RS15515	COG0009	L-threonylcarbamoyladenylate synthase
C6Y50_RS15520	COG0180	Tryptophanyl-tRNA synthetase
C6Y50_RS15530	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C6Y50_RS15555	COG1653	transport
C6Y50_RS15560	COG1175	transmembrane transport
C6Y50_RS15565	COG0395	ABC-type sugar transport system, permease component
C6Y50_RS15570	COG3842	ATPase activity
C6Y50_RS15590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C6Y50_RS15605	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C6Y50_RS15630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C6Y50_RS15645	COG0730	response to heat
C6Y50_RS15660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C6Y50_RS15665	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C6Y50_RS15685	COG0308	aminopeptidase N
C6Y50_RS15710	COG0243	molybdopterin cofactor binding
C6Y50_RS15715	COG2146	nitrite reductase [NAD(P)H] activity
C6Y50_RS15720	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y50_RS15730	COG2815	serine threonine protein kinase
C6Y50_RS15730	COG0515	serine threonine protein kinase
C6Y50_RS15735	COG2223	nitrite transmembrane transporter activity
C6Y50_RS15755	COG3707	response regulator
C6Y50_RS15760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS15770	COG2304	oxidoreductase activity
C6Y50_RS15790	COG0714	Associated with various cellular activities
C6Y50_RS15810	COG0167	dihydroorotate dehydrogenase activity
C6Y50_RS15815	COG3130	regulation of translation
C6Y50_RS15820	COG0116	Belongs to the methyltransferase superfamily
C6Y50_RS15820	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C6Y50_RS15825	COG2027	D-alanyl-D-alanine carboxypeptidase
C6Y50_RS15830	COG3171	Protein conserved in bacteria
C6Y50_RS15925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C6Y50_RS15935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C6Y50_RS15940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C6Y50_RS15945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C6Y50_RS15950	COG0072	phenylalanine-tRNA ligase activity
C6Y50_RS15955	COG0776	regulation of translation
C6Y50_RS15980	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS15985	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C6Y50_RS16010	COG0475	glutathione-regulated potassium exporter activity
C6Y50_RS16010	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C6Y50_RS16015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C6Y50_RS16025	COG1126	abc transporter atp-binding protein
C6Y50_RS16045	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C6Y50_RS16055	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6Y50_RS16060	COG0077	Prephenate dehydratase
C6Y50_RS16060	COG1605	Chorismate mutase
C6Y50_RS16070	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C6Y50_RS16075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C6Y50_RS16090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y50_RS16095	COG0625	glutathione transferase activity
C6Y50_RS16105	COG2840	Smr protein MutS2
C6Y50_RS16130	COG0800	Aldolase
C6Y50_RS16140	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS16145	COG0546	phosphoglycolate phosphatase activity
C6Y50_RS16150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C6Y50_RS16155	COG0402	S-adenosylhomocysteine deaminase activity
C6Y50_RS16190	COG0720	synthase
C6Y50_RS16195	COG2056	Na+-H+ antiporter family
C6Y50_RS16200	COG0628	permease
C6Y50_RS16225	COG2153	protein acetylation
C6Y50_RS16230	COG2850	peptidyl-arginine hydroxylation
C6Y50_RS16240	COG2915	High frequency lysogenization protein hflD homolog
C6Y50_RS16245	COG0482	sulfurtransferase activity
C6Y50_RS16265	COG1278	Cold shock
C6Y50_RS16270	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C6Y50_RS16275	COG0542	response to heat
C6Y50_RS16280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C6Y50_RS16285	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
C6Y50_RS16290	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
C6Y50_RS16295	COG0492	ferredoxin-NADP+ reductase activity
C6Y50_RS16305	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C6Y50_RS16310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C6Y50_RS16315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C6Y50_RS16320	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C6Y50_RS16325	COG1648	precorrin-2 dehydrogenase activity
C6Y50_RS16325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C6Y50_RS16345	COG1131	(ABC) transporter
C6Y50_RS16365	COG0840	transmembrane signaling receptor activity
C6Y50_RS16425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y50_RS16455	COG4172	Belongs to the ABC transporter superfamily
C6Y50_RS16460	COG4239	(ABC) transporter, permease
C6Y50_RS16465	COG4174	ABC transporter (Permease)
C6Y50_RS16475	COG4166	transmembrane transport
C6Y50_RS16485	COG1388	LysM domain
C6Y50_RS16485	COG0741	lytic transglycosylase activity
C6Y50_RS16490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C6Y50_RS16500	COG0328	RNA-DNA hybrid ribonuclease activity
C6Y50_RS16505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C6Y50_RS16515	COG1024	Enoyl-CoA hydratase
C6Y50_RS16525	COG2816	NAD+ diphosphatase activity
C6Y50_RS16540	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS16560	COG0616	signal peptide processing
C6Y50_RS16565	COG0604	alcohol dehydrogenase
C6Y50_RS16585	COG0071	Belongs to the small heat shock protein (HSP20) family
C6Y50_RS16600	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C6Y50_RS16605	COG2223	nitrite transmembrane transporter activity
C6Y50_RS16630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C6Y50_RS16630	COG2755	lipolytic protein G-D-S-L family
C6Y50_RS16650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C6Y50_RS16650	COG0316	Belongs to the HesB IscA family
C6Y50_RS16655	COG2201	protein-glutamate methylesterase activity
C6Y50_RS16660	COG3706	GGDEF domain
C6Y50_RS16670	COG2323	membrane
C6Y50_RS16690	COG1968	undecaprenyl-diphosphatase activity
C6Y50_RS16695	COG0488	(ABC) transporter
C6Y50_RS16720	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C6Y50_RS16725	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y50_RS16735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C6Y50_RS16740	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y50_RS16745	COG1609	Transcriptional regulator
C6Y50_RS16760	COG1070	Carbohydrate kinase
C6Y50_RS16780	COG1175	transmembrane transport
C6Y50_RS16795	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C6Y50_RS16815	COG0729	surface antigen
C6Y50_RS16820	COG2911	Protein conserved in bacteria
C6Y50_RS16825	COG1115	amino acid carrier protein
C6Y50_RS16840	COG0728	peptidoglycan biosynthetic process
C6Y50_RS16850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y50_RS16900	COG3321	synthase
C6Y50_RS16900	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS16900	COG0604	alcohol dehydrogenase
C6Y50_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS16920	COG0243	molybdopterin cofactor binding
C6Y50_RS16920	COG3383	formate dehydrogenase (NAD+) activity
C6Y50_RS16925	COG0243	molybdopterin cofactor binding
C6Y50_RS16925	COG3383	formate dehydrogenase (NAD+) activity
C6Y50_RS16930	COG0437	4 iron, 4 sulfur cluster binding
C6Y50_RS16935	COG2864	formate dehydrogenase
C6Y50_RS16950	COG0366	Alpha amylase catalytic
C6Y50_RS16955	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6Y50_RS16960	COG0392	lysyltransferase activity
C6Y50_RS16965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C6Y50_RS16970	COG3568	Endonuclease Exonuclease Phosphatase
C6Y50_RS16985	COG0583	DNA-binding transcription factor activity
C6Y50_RS16990	COG3384	dioxygenase
C6Y50_RS17000	COG0739	heme binding
C6Y50_RS17025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C6Y50_RS17030	COG0297	glycogen (starch) synthase activity
C6Y50_RS17050	COG3039	Transposase
C6Y50_RS17055	COG1546	Belongs to the CinA family
C6Y50_RS17055	COG1058	Belongs to the CinA family
C6Y50_RS17060	COG3264	Mechanosensitive ion channel
C6Y50_RS17060	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C6Y50_RS17065	COG3685	Protein conserved in bacteria
C6Y50_RS17090	COG0028	Belongs to the TPP enzyme family
C6Y50_RS17095	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS17100	COG0723	plastoquinol--plastocyanin reductase activity
C6Y50_RS17115	COG0583	DNA-binding transcription factor activity
C6Y50_RS17125	COG1566	PFAM secretion protein HlyD family protein
C6Y50_RS17235	COG0789	Transcriptional regulator
C6Y50_RS17300	COG5642	Protein of unknown function (DUF2384)
C6Y50_RS17325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C6Y50_RS17330	COG1742	UPF0060 membrane protein
C6Y50_RS17340	COG0431	NADPH-dependent FMN reductase
C6Y50_RS17345	COG0640	Transcriptional regulator
C6Y50_RS17350	COG2072	flavoprotein involved in K transport
C6Y50_RS17355	COG0798	PFAM Bile acid sodium symporter
C6Y50_RS17410	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y50_RS17415	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y50_RS17430	COG5002	protein histidine kinase activity
C6Y50_RS17445	COG0535	radical SAM domain protein
C6Y50_RS17455	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
C6Y50_RS17460	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6Y50_RS17500	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C6Y50_RS17505	COG0167	dihydroorotate dehydrogenase activity
C6Y50_RS17510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C6Y50_RS17520	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C6Y50_RS17525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C6Y50_RS17535	COG0544	peptidyl-prolyl cis-trans isomerase activity
C6Y50_RS17545	COG2186	Transcriptional regulator
C6Y50_RS17565	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C6Y50_RS17570	COG0215	cysteine-tRNA ligase activity
C6Y50_RS17575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C6Y50_RS17580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C6Y50_RS17585	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C6Y50_RS17610	COG4644	lycopene metabolic process
C6Y50_RS17620	COG2188	Transcriptional regulator
C6Y50_RS17630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C6Y50_RS17655	COG3627	carbon phosphorus lyase activity
C6Y50_RS17660	COG4107	phosphonate C-P lyase system protein PhnK
C6Y50_RS17665	COG4778	phosphonate C-P lyase system protein PhnL
C6Y50_RS17670	COG3454	Phosphonate metabolism
C6Y50_RS17675	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C6Y50_RS17680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C6Y50_RS17750	COG0668	transmembrane transport
C6Y50_RS17765	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C6Y50_RS17780	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C6Y50_RS17795	COG0372	Belongs to the citrate synthase family
C6Y50_RS17805	COG1802	Transcriptional regulator
C6Y50_RS17830	COG0560	Phosphoserine phosphatase
C6Y50_RS17845	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C6Y50_RS17850	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C6Y50_RS17920	COG4181	ATPase activity
C6Y50_RS17925	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
C6Y50_RS17945	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
C6Y50_RS17950	COG0084	hydrolase, TatD family'
C6Y50_RS17965	COG3842	ATPase activity
C6Y50_RS17970	COG3665	Urea carboxylase-associated protein
C6Y50_RS17980	COG0439	Biotin carboxylase
C6Y50_RS17995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C6Y50_RS18005	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS18025	COG1335	isochorismatase
C6Y50_RS18035	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C6Y50_RS18040	COG1116	anion transmembrane transporter activity
C6Y50_RS18045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C6Y50_RS18050	COG0174	glutamine synthetase
C6Y50_RS18100	COG2920	part of a sulfur-relay system
C6Y50_RS18105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C6Y50_RS18110	COG0435	Glutathione S-transferase
C6Y50_RS18115	COG2205	protein histidine kinase activity
C6Y50_RS18115	COG0784	Response regulator, receiver
C6Y50_RS18130	COG1025	Belongs to the peptidase M16 family
C6Y50_RS18135	COG0789	Transcriptional regulator
C6Y50_RS18145	COG0302	gtp cyclohydrolase
C6Y50_RS18150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C6Y50_RS18170	COG1366	Belongs to the anti-sigma-factor antagonist family
C6Y50_RS18180	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C6Y50_RS18185	COG1090	epimerase
C6Y50_RS18190	COG3272	Protein of unknown function (DUF1722)
C6Y50_RS18195	COG0789	Transcriptional regulator
C6Y50_RS18200	COG0415	Belongs to the DNA photolyase family
C6Y50_RS18210	COG4221	oxidoreductase activity
C6Y50_RS18225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C6Y50_RS18230	COG0840	transmembrane signaling receptor activity
C6Y50_RS18245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y50_RS18245	COG2146	nitrite reductase [NAD(P)H] activity
C6Y50_RS18250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C6Y50_RS18250	COG2146	nitrite reductase [NAD(P)H] activity
C6Y50_RS18260	COG0515	serine threonine protein kinase
C6Y50_RS18265	COG0210	DNA helicase
C6Y50_RS18310	COG5002	protein histidine kinase activity
C6Y50_RS18310	COG5001	Diguanylate cyclase
C6Y50_RS18310	COG3447	MASE1 domain protein
C6Y50_RS18325	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C6Y50_RS18345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C6Y50_RS18350	COG4191	Histidine kinase
C6Y50_RS18350	COG0784	Response regulator, receiver
C6Y50_RS18355	COG4991	sh3 domain protein
C6Y50_RS18370	COG2207	Transcriptional regulator
C6Y50_RS18385	COG0058	SHG alpha-glucan phosphorylase activity
C6Y50_RS18390	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS18395	COG2205	protein histidine kinase activity
C6Y50_RS18410	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C6Y50_RS18445	COG1024	Enoyl-CoA hydratase
C6Y50_RS18450	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS18460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y50_RS18465	COG0318	PFAM AMP-dependent synthetase and ligase
C6Y50_RS18470	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS18475	COG0183	Belongs to the thiolase family
C6Y50_RS18490	COG1238	metal cluster binding
C6Y50_RS18515	COG0714	Associated with various cellular activities
C6Y50_RS18525	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
C6Y50_RS18530	COG0709	Synthesizes selenophosphate from selenide and ATP
C6Y50_RS18540	COG0628	permease
C6Y50_RS18575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C6Y50_RS18580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C6Y50_RS18590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
C6Y50_RS18620	COG0326	Molecular chaperone. Has ATPase activity
C6Y50_RS18655	COG0045	succinate-CoA ligase (ADP-forming) activity
C6Y50_RS18675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C6Y50_RS18680	COG1053	succinate dehydrogenase
C6Y50_RS18685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
C6Y50_RS18690	COG2009	succinate dehydrogenase
C6Y50_RS18710	COG3123	guanosine phosphorylase activity
C6Y50_RS18740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C6Y50_RS18745	COG3115	cell septum assembly
C6Y50_RS18755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C6Y50_RS18760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y50_RS18775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C6Y50_RS18775	COG2010	Cytochrome c
C6Y50_RS18780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C6Y50_RS18800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
C6Y50_RS18810	COG0840	transmembrane signaling receptor activity
C6Y50_RS18820	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y50_RS18830	COG2010	Cytochrome c
C6Y50_RS18835	COG3278	Belongs to the heme-copper respiratory oxidase family
C6Y50_RS18850	COG2010	Cytochrome c
C6Y50_RS18880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C6Y50_RS18890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C6Y50_RS18895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C6Y50_RS18910	COG0573	inorganic phosphate transmembrane transporter activity
C6Y50_RS18925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C6Y50_RS18930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C6Y50_RS18940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C6Y50_RS18970	COG0446	pyridine nucleotide-disulphide oxidoreductase
C6Y50_RS18970	COG1902	pentaerythritol trinitrate reductase activity
C6Y50_RS18990	COG1294	oxidase, subunit
C6Y50_RS18995	COG1271	oxidase subunit
C6Y50_RS19020	COG2814	Major facilitator Superfamily
C6Y50_RS19025	COG0655	NAD(P)H dehydrogenase (quinone) activity
C6Y50_RS19055	COG0789	Transcriptional regulator
C6Y50_RS19065	COG0477	Major facilitator Superfamily
C6Y50_RS19080	COG0254	rRNA binding
C6Y50_RS19110	COG0789	Transcriptional regulator
C6Y50_RS19145	COG1286	toxin biosynthetic process
C6Y50_RS19150	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C6Y50_RS19155	COG0285	dihydrofolate synthase activity
C6Y50_RS19160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C6Y50_RS19165	COG0135	phosphoribosylanthranilate isomerase activity
C6Y50_RS19195	COG0066	3-isopropylmalate dehydratase activity
C6Y50_RS19200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C6Y50_RS19215	COG1028	Short-chain dehydrogenase reductase Sdr
C6Y50_RS19280	COG0250	Participates in transcription elongation, termination and antitermination
C6Y50_RS19310	COG0297	glycogen (starch) synthase activity
C6Y50_RS19335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C6Y50_RS19340	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C6Y50_RS19345	COG1012	belongs to the aldehyde dehydrogenase family
C6Y50_RS19350	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C6Y50_RS19355	COG0133	tryptophan synthase activity
C6Y50_RS19375	COG0653	protein targeting
C6Y50_RS19440	COG0183	Belongs to the thiolase family
C6Y50_RS19445	COG1250	3-hydroxyacyl-CoA dehydrogenase
C6Y50_RS19445	COG1024	Enoyl-CoA hydratase
C6Y50_RS19450	COG1770	oligopeptidase
C6Y50_RS19460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C6Y50_RS19480	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C6Y50_RS19485	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C6Y50_RS19525	COG2301	Belongs to the HpcH HpaI aldolase family
C6Y50_RS19535	COG2079	MmgE PrpD family protein
C6Y50_RS19545	COG1960	acyl-CoA dehydrogenase activity
C6Y50_RS19550	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C6Y50_RS19555	COG0583	DNA-binding transcription factor activity
C6Y50_RS19580	COG0840	transmembrane signaling receptor activity
C6Y50_RS19595	COG1054	Belongs to the UPF0176 family
C6Y50_RS19600	COG0271	Belongs to the BolA IbaG family
C6Y50_RS19610	COG0114	fumarate hydratase activity
C6Y50_RS19630	COG0784	Response regulator, receiver
C6Y50_RS19630	COG4191	Histidine kinase
C6Y50_RS19670	COG3135	benzoate transporter
C6Y50_RS19675	COG3485	protocatechuate 3,4-dioxygenase
C6Y50_RS19680	COG4829	muconolactone delta-isomerase
C6Y50_RS19685	COG4948	Mandelate Racemase Muconate Lactonizing
C6Y50_RS19690	COG2814	Major facilitator Superfamily
C6Y50_RS19725	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C6Y50_RS19750	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C6Y50_RS19760	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS19770	COG2853	Lipoprotein
C6Y50_RS19780	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C6Y50_RS19780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C6Y50_RS19785	COG0842	Transport permease protein
C6Y50_RS19790	COG1131	(ABC) transporter
C6Y50_RS19795	COG2988	succinylglutamate desuccinylase activity
C6Y50_RS19840	COG0668	transmembrane transport
C6Y50_RS19850	COG2205	protein histidine kinase activity
C6Y50_RS19855	COG0745	RESPONSE REGULATOR receiver
C6Y50_RS19865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C6Y50_RS19870	COG0583	DNA-binding transcription factor activity
C6Y50_RS19875	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C6Y50_RS19885	COG2226	methyltransferase
C6Y50_RS19890	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
C6Y50_RS19915	COG0583	DNA-binding transcription factor activity
C6Y50_RS19940	COG2130	NADP-dependent
C6Y50_RS19955	COG3300	MHYT domain
C6Y50_RS19955	COG5001	Diguanylate cyclase
C6Y50_RS19965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y50_RS20025	COG1113	amino acid transport
C6Y50_RS20030	COG0084	hydrolase, TatD family'
C6Y50_RS20045	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C6Y50_RS20050	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C6Y50_RS20060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C6Y50_RS20065	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C6Y50_RS20080	COG0416	fatty acid biosynthetic process
C6Y50_RS20085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C6Y50_RS20095	COG0424	maF-like protein
C6Y50_RS20100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C6Y50_RS20100	COG0616	signal peptide processing
C6Y50_RS20120	COG1530	ribonuclease E activity
C6Y50_RS20125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C6Y50_RS20130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C6Y50_RS20135	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
C6Y50_RS20140	COG2835	tetraacyldisaccharide 4'-kinase activity
C6Y50_RS20145	COG1663	tetraacyldisaccharide 4'-kinase activity
C6Y50_RS20155	COG0811	peptide transport
C6Y50_RS20160	COG2333	competence protein COMEC
C6Y50_RS20160	COG0658	competence protein
C6Y50_RS20170	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6Y50_RS20175	COG1136	(ABC) transporter
C6Y50_RS20180	COG4591	ABC-type transport system involved in lipoprotein release permease component
C6Y50_RS20195	COG0584	glycerophosphoryl diester phosphodiesterase
C6Y50_RS20200	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C6Y50_RS20210	COG1477	protein flavinylation
C6Y50_RS20220	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
C6Y50_RS20235	COG1805	sodium ion transport
C6Y50_RS20250	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C6Y50_RS20260	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C6Y50_RS20275	COG1793	dna ligase
C6Y50_RS20280	COG1201	RNA secondary structure unwinding
C6Y50_RS20305	COG3956	TIGRFAM MazG family protein
C6Y50_RS20310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C6Y50_RS20315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C6Y50_RS20330	COG2860	membrane
C6Y50_RS20335	COG2205	protein histidine kinase activity
C6Y50_RS20335	COG0784	Response regulator, receiver
C6Y50_RS20335	COG5002	protein histidine kinase activity
C6Y50_RS20340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C6Y50_RS20340	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
C6Y50_RS20360	COG0583	DNA-binding transcription factor activity
C6Y50_RS20375	COG0513	Belongs to the DEAD box helicase family
C6Y50_RS20420	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C6Y50_RS20425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C6Y50_RS20430	COG2226	methyltransferase
C6Y50_RS20455	COG1131	(ABC) transporter
C6Y50_RS20460	COG0456	acetyltransferase
C6Y50_RS20485	COG2937	Belongs to the GPAT DAPAT family
C6Y50_RS20490	COG0456	acetyltransferase
C6Y50_RS20505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C6Y50_RS20520	COG0642	Histidine kinase
C6Y50_RS20560	COG2132	Multicopper oxidase
C6Y50_RS20615	COG1472	Belongs to the glycosyl hydrolase 3 family
C6Y50_RS20625	COG1346	cytolysis
C6Y50_RS20630	COG1380	Effector of murein hydrolase LrgA
C6Y50_RS20635	COG0348	domain, Protein
C6Y50_RS20640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C6Y50_RS20660	COG1309	transcriptional regulator
C6Y50_RS20665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C6Y50_RS20670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C6Y50_RS20705	COG0742	ribosomal rna small subunit methyltransferase
C6Y50_RS20730	COG0563	adenylate kinase activity
C6Y50_RS20735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C6Y50_RS20775	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C6Y50_RS20790	COG1902	pentaerythritol trinitrate reductase activity
C6Y50_RS20795	COG0243	molybdopterin cofactor binding
C6Y50_RS20800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C6Y50_RS20810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y50_RS20815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C6Y50_RS20820	COG1984	allophanate hydrolase subunit 2
C6Y50_RS20825	COG4336	lyase activity
C6Y50_RS20830	COG1914	H( )-stimulated, divalent metal cation uptake system
C6Y50_RS20865	COG0545	Peptidyl-prolyl cis-trans isomerase
C6Y50_RS20880	COG2974	May be involved in recombination
C6Y50_RS20885	COG2814	Major facilitator Superfamily
C6Y50_RS20905	COG2205	protein histidine kinase activity
C6Y50_RS20910	COG3174	membrane
C6Y50_RS20945	COG0417	DNA replication proofreading
C6Y50_RS20955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C6Y50_RS20965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C6Y50_RS20975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C6Y50_RS20985	COG0425	Belongs to the sulfur carrier protein TusA family
C6Y50_RS20995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C6Y50_RS21000	COG0427	acetyl-CoA hydrolase
C6Y50_RS21015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C6Y50_RS21020	COG0602	queuosine metabolic process
C6Y50_RS21025	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
C6Y50_RS21030	COG2885	chlorophyll binding
C6Y50_RS21035	COG0823	Involved in the tonB-independent uptake of proteins
C6Y50_RS21055	COG0824	Thioesterase
C6Y50_RS21060	COG2255	four-way junction helicase activity
C6Y50_RS21065	COG0632	four-way junction helicase activity
C6Y50_RS21070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C6Y50_RS21080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C6Y50_RS21085	COG0783	Belongs to the Dps family
C6Y50_RS21095	COG2900	Belongs to the SlyX family
C6Y50_RS21110	COG0442	prolyl-tRNA aminoacylation
C6Y50_RS21125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins