locus-tag	class	description
CXB48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXB48_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXB48_RS00030	COG3706	GGDEF domain
CXB48_RS00045	COG0751	glycine-tRNA ligase activity
CXB48_RS00055	COG2818	Glycosylase
CXB48_RS00075	COG1126	abc transporter atp-binding protein
CXB48_RS00080	COG0765	amino acid transport
CXB48_RS00085	COG0765	amino acid transport
CXB48_RS00090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXB48_RS00095	COG0569	domain protein
CXB48_RS00100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CXB48_RS00105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CXB48_RS00110	COG0242	peptide deformylase activity
CXB48_RS00120	COG0758	DNA mediated transformation
CXB48_RS00125	COG0009	L-threonylcarbamoyladenylate synthase
CXB48_RS00135	COG0408	coproporphyrinogen oxidase activity
CXB48_RS00140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CXB48_RS00155	COG1686	Belongs to the peptidase S11 family
CXB48_RS00195	COG2011	ABC-type metal ion transport system permease component
CXB48_RS00215	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CXB48_RS00220	COG1121	(ABC) transporter
CXB48_RS00225	COG0735	belongs to the Fur family
CXB48_RS00235	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CXB48_RS00240	COG1012	belongs to the aldehyde dehydrogenase family
CXB48_RS00260	COG0745	RESPONSE REGULATOR receiver
CXB48_RS00265	COG5002	protein histidine kinase activity
CXB48_RS00275	COG0745	RESPONSE REGULATOR receiver
CXB48_RS00280	COG5002	protein histidine kinase activity
CXB48_RS00285	COG3039	Transposase
CXB48_RS00290	COG0745	RESPONSE REGULATOR receiver
CXB48_RS00295	COG4191	Histidine kinase
CXB48_RS00305	COG3706	GGDEF domain
CXB48_RS00315	COG2957	Belongs to the agmatine deiminase family
CXB48_RS00330	COG0174	glutamine synthetase
CXB48_RS00335	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CXB48_RS00340	COG0174	glutamine synthetase
CXB48_RS00365	COG3842	ATPase activity
CXB48_RS00370	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXB48_RS00375	COG1177	transmembrane transport
CXB48_RS00455	COG0842	Transport permease protein
CXB48_RS00460	COG1129	ABC transporter
CXB48_RS00460	COG0842	Transport permease protein
CXB48_RS00465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXB48_RS00480	COG1127	ABC transporter
CXB48_RS00485	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXB48_RS00490	COG0753	catalase activity
CXB48_RS00495	COG2010	Cytochrome c
CXB48_RS00505	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CXB48_RS00510	COG3909	cytochrome
CXB48_RS00525	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXB48_RS00525	COG1024	Enoyl-CoA hydratase
CXB48_RS00530	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS00535	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS00540	COG2814	Major facilitator Superfamily
CXB48_RS00560	COG0318	PFAM AMP-dependent synthetase and ligase
CXB48_RS00565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CXB48_RS00570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CXB48_RS00585	COG1611	Belongs to the LOG family
CXB48_RS00630	COG2207	Transcriptional regulator
CXB48_RS00640	COG2249	NAD(P)H dehydrogenase (quinone) activity
CXB48_RS00710	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CXB48_RS00715	COG0583	DNA-binding transcription factor activity
CXB48_RS00755	COG2706	6-phosphogluconolactonase activity
CXB48_RS00760	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS00765	COG4191	Histidine kinase
CXB48_RS00765	COG0784	Response regulator, receiver
CXB48_RS00790	COG3795	YCII-related domain
CXB48_RS00795	COG4941	Belongs to the sigma-70 factor family
CXB48_RS00800	COG2204	response regulator
CXB48_RS00805	COG4191	Histidine kinase
CXB48_RS00815	COG0589	response to stress
CXB48_RS00820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXB48_RS00830	COG0509	glycine decarboxylation via glycine cleavage system
CXB48_RS00845	COG3276	selenocysteine insertion sequence binding
CXB48_RS00850	COG1921	L-seryl-tRNASec selenium transferase activity
CXB48_RS00855	COG3058	Necessary for formate dehydrogenase activity
CXB48_RS00860	COG2864	formate dehydrogenase
CXB48_RS00865	COG0437	4 iron, 4 sulfur cluster binding
CXB48_RS00880	COG1764	response to oxidative stress
CXB48_RS00895	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXB48_RS00900	COG0210	DNA helicase
CXB48_RS00910	COG0826	peptidase U32
CXB48_RS00915	COG2841	Protein conserved in bacteria
CXB48_RS00920	COG0527	aspartate kinase activity
CXB48_RS00925	COG5285	phytanoyl-CoA dioxygenase
CXB48_RS00930	COG1917	Cupin 2, conserved barrel domain protein
CXB48_RS00935	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXB48_RS00945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CXB48_RS00950	COG0837	glucose binding
CXB48_RS00950	COG1737	Transcriptional regulator
CXB48_RS00960	COG0583	DNA-binding transcription factor activity
CXB48_RS00965	COG0439	Biotin carboxylase
CXB48_RS00970	COG5016	pyruvate
CXB48_RS00970	COG0511	ligase activity, forming carbon-carbon bonds
CXB48_RS00985	COG2066	Belongs to the glutaminase family
CXB48_RS01000	COG0252	asparaginase activity
CXB48_RS01005	COG1115	amino acid carrier protein
CXB48_RS01015	COG1301	dicarboxylic acid transport
CXB48_RS01025	COG0583	DNA-binding transcription factor activity
CXB48_RS01035	COG1082	Xylose isomerase domain protein TIM barrel
CXB48_RS01035	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CXB48_RS01040	COG2205	protein histidine kinase activity
CXB48_RS01070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXB48_RS01080	COG4208	sulfate ABC transporter
CXB48_RS01090	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CXB48_RS01095	COG5583	Uncharacterized small protein (DUF2292)
CXB48_RS01105	COG0450	alkyl hydroperoxide reductase
CXB48_RS01125	COG1715	Restriction endonuclease
CXB48_RS01155	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXB48_RS01190	COG3657	addiction module killer protein
CXB48_RS01195	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXB48_RS01235	COG3561	AntA/AntB antirepressor
CXB48_RS01415	COG4695	Portal protein
CXB48_RS01420	COG3344	reverse transcriptase
CXB48_RS01450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXB48_RS01455	COG1764	response to oxidative stress
CXB48_RS01470	COG2989	Protein conserved in bacteria
CXB48_RS01480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CXB48_RS01490	COG1392	Phosphate transport regulator
CXB48_RS01495	COG0306	phosphate transporter
CXB48_RS01510	COG2918	glutathione biosynthetic process
CXB48_RS01520	COG2183	response to ionizing radiation
CXB48_RS01525	COG0457	Tetratricopeptide repeat
CXB48_RS01525	COG3118	belongs to the thioredoxin family
CXB48_RS01530	COG1215	transferase activity, transferring glycosyl groups
CXB48_RS01535	COG1215	transferase activity, transferring glycosyl groups
CXB48_RS01540	COG1192	Involved in chromosome partitioning
CXB48_RS01550	COG2194	sulfuric ester hydrolase activity
CXB48_RS01580	COG0189	ligase activity
CXB48_RS01585	COG4067	protein conserved in archaea
CXB48_RS01585	COG0189	ligase activity
CXB48_RS01590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CXB48_RS01600	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CXB48_RS01610	COG0778	Nitroreductase
CXB48_RS01620	COG0514	ATP-dependent DNA helicase (RecQ)
CXB48_RS01625	COG0840	transmembrane signaling receptor activity
CXB48_RS01640	COG0667	Aldo Keto reductase
CXB48_RS01665	COG0784	Response regulator, receiver
CXB48_RS01665	COG4191	Histidine kinase
CXB48_RS01670	COG2205	protein histidine kinase activity
CXB48_RS01680	COG2172	sigma factor antagonist activity
CXB48_RS01685	COG1366	Belongs to the anti-sigma-factor antagonist family
CXB48_RS01690	COG1366	Belongs to the anti-sigma-factor antagonist family
CXB48_RS01700	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXB48_RS01700	COG1024	Enoyl-CoA hydratase
CXB48_RS01705	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS01710	COG1454	alcohol dehydrogenase
CXB48_RS01725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXB48_RS01730	COG4191	Histidine kinase
CXB48_RS01730	COG0784	Response regulator, receiver
CXB48_RS01735	COG1011	Hydrolase
CXB48_RS01740	COG0494	nUDIX hydrolase
CXB48_RS01745	COG1218	3'(2'),5'-bisphosphate nucleotidase
CXB48_RS01760	COG0058	SHG alpha-glucan phosphorylase activity
CXB48_RS01765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CXB48_RS01795	COG1490	D-aminoacyl-tRNA deacylase activity
CXB48_RS01815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXB48_RS01820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CXB48_RS01825	COG0140	phosphoribosyl-ATP diphosphatase activity
CXB48_RS01830	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CXB48_RS01835	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CXB48_RS01845	COG2226	methyltransferase
CXB48_RS01855	COG0840	transmembrane signaling receptor activity
CXB48_RS01865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CXB48_RS01875	COG0243	molybdopterin cofactor binding
CXB48_RS01895	COG3852	Histidine kinase
CXB48_RS01915	COG0301	tRNA thio-modification
CXB48_RS01915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXB48_RS01920	COG1217	gtp-binding protein TYPA
CXB48_RS01930	COG3493	citrate carrier protein
CXB48_RS01935	COG3290	protein histidine kinase activity
CXB48_RS01940	COG4565	transcriptional regulatory protein
CXB48_RS01965	COG2204	response regulator
CXB48_RS01970	COG4807	Protein conserved in bacteria
CXB48_RS01995	COG5001	Diguanylate cyclase
CXB48_RS02000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CXB48_RS02015	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS02030	COG1966	Carbon starvation protein
CXB48_RS02045	COG1320	monovalent cation:proton antiporter activity
CXB48_RS02065	COG0651	ATP synthesis coupled electron transport
CXB48_RS02070	COG0651	ATP synthesis coupled electron transport
CXB48_RS02110	COG2197	response regulator
CXB48_RS02145	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXB48_RS02150	COG0277	FAD linked oxidase domain protein
CXB48_RS02155	COG0179	Fumarylacetoacetate (FAA) hydrolase
CXB48_RS02175	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CXB48_RS02180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CXB48_RS02200	COG0494	nUDIX hydrolase
CXB48_RS02215	COG0730	response to heat
CXB48_RS02220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CXB48_RS02225	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CXB48_RS02230	COG1192	Involved in chromosome partitioning
CXB48_RS02240	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXB48_RS02270	COG0739	heme binding
CXB48_RS02280	COG1253	flavin adenine dinucleotide binding
CXB48_RS02295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CXB48_RS02305	COG2186	Transcriptional regulator
CXB48_RS02310	COG0277	FAD linked oxidase domain protein
CXB48_RS02315	COG0277	FAD linked oxidase domain protein
CXB48_RS02320	COG0247	lactate metabolic process
CXB48_RS02325	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CXB48_RS02330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CXB48_RS02335	COG1620	l-lactate permease
CXB48_RS02360	COG0583	DNA-binding transcription factor activity
CXB48_RS02365	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS02380	COG0583	DNA-binding transcription factor activity
CXB48_RS02385	COG1704	LemA family
CXB48_RS02390	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
CXB48_RS02410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXB48_RS02430	COG2080	2 iron, 2 sulfur cluster binding
CXB48_RS02450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXB48_RS02455	COG1758	RNA polymerase activity
CXB48_RS02465	COG1561	YicC-like family, N-terminal region
CXB48_RS02470	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CXB48_RS02480	COG0708	Exodeoxyribonuclease III
CXB48_RS02485	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CXB48_RS02500	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CXB48_RS02510	COG0756	dUTP diphosphatase activity
CXB48_RS02515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CXB48_RS02520	COG2003	Belongs to the UPF0758 family
CXB48_RS02535	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXB48_RS02555	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXB48_RS02560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXB48_RS02570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXB48_RS02575	COG0251	oxidation-reduction process
CXB48_RS02595	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXB48_RS02605	COG0366	Alpha amylase catalytic
CXB48_RS02610	COG0366	Alpha amylase catalytic
CXB48_RS02615	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXB48_RS02625	COG1454	alcohol dehydrogenase
CXB48_RS02635	COG1414	Transcriptional regulator
CXB48_RS02640	COG1272	protein, Hemolysin III
CXB48_RS02645	COG0210	DNA helicase
CXB48_RS02655	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXB48_RS02660	COG0606	chelatase, subunit chli
CXB48_RS02670	COG0347	Belongs to the P(II) protein family
CXB48_RS02675	COG0004	ammonium transporteR
CXB48_RS02680	COG0004	ammonium transporteR
CXB48_RS02700	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CXB48_RS02710	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CXB48_RS02725	COG1965	Belongs to the frataxin family
CXB48_RS02730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXB48_RS02765	COG0165	Argininosuccinate lyase
CXB48_RS02775	COG3275	phosphorelay sensor kinase activity
CXB48_RS02785	COG0181	hydroxymethylbilane synthase activity
CXB48_RS02805	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CXB48_RS02830	COG0488	(ABC) transporter
CXB48_RS02840	COG0861	Integral membrane protein TerC family
CXB48_RS02845	COG1280	lysine exporter protein (LysE YggA)
CXB48_RS02850	COG1671	Belongs to the UPF0178 family
CXB48_RS02865	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
CXB48_RS02875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CXB48_RS02880	COG0248	Ppx GppA phosphatase
CXB48_RS02895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CXB48_RS02910	COG0018	arginyl-trna synthetase
CXB48_RS02915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CXB48_RS02920	COG0254	rRNA binding
CXB48_RS02930	COG0281	malic enzyme
CXB48_RS02965	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CXB48_RS02970	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CXB48_RS02980	COG0070	glutamate synthase
CXB48_RS02980	COG0067	glutamate synthase
CXB48_RS02980	COG0069	glutamate synthase activity
CXB48_RS02985	COG0493	'glutamate synthase
CXB48_RS02995	COG2814	Major facilitator Superfamily
CXB48_RS03000	COG0583	DNA-binding transcription factor activity
CXB48_RS03010	COG3118	belongs to the thioredoxin family
CXB48_RS03015	COG2873	o-acetylhomoserine
CXB48_RS03020	COG3273	potassium ion transport
CXB48_RS03020	COG0471	metal ion transport
CXB48_RS03025	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS03035	COG1024	Enoyl-CoA hydratase
CXB48_RS03040	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXB48_RS03045	COG0183	Belongs to the thiolase family
CXB48_RS03080	COG1715	Restriction endonuclease
CXB48_RS03100	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXB48_RS03120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXB48_RS03125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CXB48_RS03130	COG0358	DNA primase activity
CXB48_RS03135	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CXB48_RS03140	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CXB48_RS03145	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CXB48_RS03160	COG0617	tRNA 3'-terminal CCA addition
CXB48_RS03165	COG2719	SpoVR family
CXB48_RS03170	COG2718	Belongs to the UPF0229 family
CXB48_RS03175	COG2766	serine protein kinase
CXB48_RS03180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXB48_RS03185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXB48_RS03190	COG2967	ApaG domain
CXB48_RS03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CXB48_RS03200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CXB48_RS03205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXB48_RS03210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CXB48_RS03220	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CXB48_RS03225	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXB48_RS03240	COG2197	response regulator
CXB48_RS03245	COG3842	ATPase activity
CXB48_RS03255	COG1176	ABC-type spermidine putrescine transport system, permease component I
CXB48_RS03260	COG1177	transmembrane transport
CXB48_RS03270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CXB48_RS03275	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CXB48_RS03280	COG0546	phosphoglycolate phosphatase activity
CXB48_RS03290	COG0512	Glutamine amidotransferase of anthranilate synthase
CXB48_RS03295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXB48_RS03300	COG0134	indole-3-glycerol-phosphate synthase activity
CXB48_RS03310	COG1765	OsmC-like protein
CXB48_RS03315	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CXB48_RS03320	COG0537	adenosine 5'-monophosphoramidase activity
CXB48_RS03325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CXB48_RS03335	COG1981	membrane
CXB48_RS03340	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CXB48_RS03345	COG0316	Belongs to the HesB IscA family
CXB48_RS03350	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CXB48_RS03355	COG0739	heme binding
CXB48_RS03360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CXB48_RS03395	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CXB48_RS03395	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CXB48_RS03400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CXB48_RS03425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXB48_RS03445	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CXB48_RS03450	COG0081	regulation of translation
CXB48_RS03455	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CXB48_RS03460	COG0222	ribosome binding
CXB48_RS03465	COG0085	RNA polymerase activity
CXB48_RS03470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CXB48_RS03475	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CXB48_RS03480	COG0049	tRNA binding
CXB48_RS03485	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CXB48_RS03490	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CXB48_RS03495	COG0051	transcription antitermination factor activity, RNA binding
CXB48_RS03500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CXB48_RS03505	COG0088	Forms part of the polypeptide exit tunnel
CXB48_RS03510	COG0089	rRNA binding
CXB48_RS03515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CXB48_RS03520	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CXB48_RS03525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CXB48_RS03530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CXB48_RS03535	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CXB48_RS03540	COG0255	Belongs to the universal ribosomal protein uL29 family
CXB48_RS03545	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CXB48_RS03550	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CXB48_RS03555	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CXB48_RS03560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CXB48_RS03565	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CXB48_RS03570	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CXB48_RS03575	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CXB48_RS03585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CXB48_RS03590	COG1841	ribosomal large subunit assembly
CXB48_RS03595	COG0200	Binds to the 23S rRNA
CXB48_RS03605	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CXB48_RS03610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CXB48_RS03615	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CXB48_RS03620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CXB48_RS03625	COG0202	RNA polymerase activity
CXB48_RS03630	COG0203	ribosomal protein L17
CXB48_RS03645	COG2814	Major facilitator Superfamily
CXB48_RS03670	COG3039	Transposase
CXB48_RS03685	COG0811	peptide transport
CXB48_RS03690	COG0811	peptide transport
CXB48_RS03695	COG0848	biopolymer transport protein
CXB48_RS03720	COG4181	ATPase activity
CXB48_RS03735	COG3118	belongs to the thioredoxin family
CXB48_RS03740	COG2391	methyltransferase activity
CXB48_RS03745	COG0425	Belongs to the sulfur carrier protein TusA family
CXB48_RS03755	COG2264	protein methyltransferase activity
CXB48_RS03770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXB48_RS03770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CXB48_RS03785	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CXB48_RS03790	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CXB48_RS03800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CXB48_RS03805	COG3577	Aspartyl protease
CXB48_RS03810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CXB48_RS03825	COG4206	TonB-dependent receptor
CXB48_RS03835	COG0420	3'-5' exonuclease activity
CXB48_RS03900	COG1040	competence protein
CXB48_RS03905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CXB48_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS03915	COG2610	gluconate transmembrane transporter activity
CXB48_RS03920	COG2031	fatty acid transporter
CXB48_RS03930	COG1522	sequence-specific DNA binding
CXB48_RS03945	COG0733	neurotransmitter:sodium symporter activity
CXB48_RS03965	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CXB48_RS03975	COG0625	glutathione transferase activity
CXB48_RS03980	COG0733	neurotransmitter:sodium symporter activity
CXB48_RS04015	COG0513	Belongs to the DEAD box helicase family
CXB48_RS04045	COG0123	including yeast histone deacetylase and acetoin utilization protein
CXB48_RS04055	COG1946	Acyl-CoA thioesterase
CXB48_RS04065	COG2321	neutral zinc metallopeptidase
CXB48_RS04090	COG2197	response regulator
CXB48_RS04095	COG3850	Histidine kinase
CXB48_RS04100	COG2223	nitrite transmembrane transporter activity
CXB48_RS04110	COG2223	nitrite transmembrane transporter activity
CXB48_RS04115	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CXB48_RS04120	COG1140	nitrate reductase beta subunit
CXB48_RS04125	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CXB48_RS04130	COG2181	nitrate reductase activity
CXB48_RS04140	COG0789	Transcriptional regulator
CXB48_RS04165	COG3253	May function as heme-dependent peroxidase
CXB48_RS04180	COG0243	molybdopterin cofactor binding
CXB48_RS04185	COG1140	nitrate reductase beta subunit
CXB48_RS04190	COG3381	protein complex oligomerization
CXB48_RS04195	COG2010	Cytochrome c
CXB48_RS04200	COG0489	protein tyrosine kinase activity
CXB48_RS04205	COG3039	Transposase
CXB48_RS04220	COG0521	Mo-molybdopterin cofactor biosynthetic process
CXB48_RS04225	COG0303	'Molybdopterin
CXB48_RS04230	COG3038	cytochrome b561
CXB48_RS04260	COG1022	Amp-dependent synthetase and ligase
CXB48_RS04285	COG0642	Histidine kinase
CXB48_RS04295	COG3642	lipopolysaccharide core region biosynthetic process
CXB48_RS04305	COG1368	sulfuric ester hydrolase activity
CXB48_RS04310	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXB48_RS04315	COG2252	PERMEase
CXB48_RS04325	COG3608	succinylglutamate desuccinylase aspartoacylase
CXB48_RS04325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CXB48_RS04330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXB48_RS04335	COG2080	2 iron, 2 sulfur cluster binding
CXB48_RS04340	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CXB48_RS04345	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CXB48_RS04370	COG0789	Transcriptional regulator
CXB48_RS04375	COG2813	Specifically methylates the guanine in position
CXB48_RS04410	COG3039	Transposase
CXB48_RS04420	COG0488	(ABC) transporter
CXB48_RS04430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CXB48_RS04435	COG2020	methyltransferase activity
CXB48_RS04455	COG2841	Protein conserved in bacteria
CXB48_RS04460	COG1970	mechanosensitive ion channel activity
CXB48_RS04470	COG1067	ATP-dependent peptidase activity
CXB48_RS04480	COG2862	Uncharacterized protein family, UPF0114
CXB48_RS04490	COG3046	protein related to deoxyribodipyrimidine photolyase
CXB48_RS04500	COG0545	Peptidyl-prolyl cis-trans isomerase
CXB48_RS04510	COG0142	geranyltranstransferase activity
CXB48_RS04515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CXB48_RS04520	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CXB48_RS04525	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CXB48_RS04530	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CXB48_RS04535	COG3045	CreA protein
CXB48_RS04540	COG0268	Binds directly to 16S ribosomal RNA
CXB48_RS04550	COG0196	riboflavin kinase activity
CXB48_RS04555	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CXB48_RS04560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXB48_RS04565	COG1047	Peptidyl-prolyl cis-trans
CXB48_RS04570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CXB48_RS04605	COG4968	Prepilin-type N-terminal cleavage methylation domain
CXB48_RS04610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXB48_RS04615	COG0023	Translation Initiation Factor
CXB48_RS04630	COG0534	Mate efflux family protein
CXB48_RS04660	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXB48_RS04675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CXB48_RS04675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXB48_RS04680	COG1105	Belongs to the carbohydrate kinase PfkB family
CXB48_RS04685	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXB48_RS04685	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CXB48_RS04685	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CXB48_RS04690	COG4993	Dehydrogenase
CXB48_RS04695	COG2852	Protein conserved in bacteria
CXB48_RS04700	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CXB48_RS04705	COG0019	diaminopimelate decarboxylase activity
CXB48_RS04715	COG3128	pkhd-type hydroxylase
CXB48_RS04720	COG4774	siderophore transport
CXB48_RS04725	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CXB48_RS04750	COG3039	Transposase
CXB48_RS04770	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CXB48_RS04780	COG0739	heme binding
CXB48_RS04795	COG0530	calcium, potassium:sodium antiporter activity
CXB48_RS04810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXB48_RS04820	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CXB48_RS04825	COG1077	Cell shape determining protein MreB Mrl
CXB48_RS04830	COG1792	Involved in formation and maintenance of cell shape
CXB48_RS04850	COG1530	ribonuclease E activity
CXB48_RS04860	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CXB48_RS04865	COG0312	modulator of DNA gyrase
CXB48_RS04875	COG0312	modulator of DNA gyrase
CXB48_RS04880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CXB48_RS04885	COG1660	Displays ATPase and GTPase activities
CXB48_RS04900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CXB48_RS04905	COG1137	ATPase activity
CXB48_RS04920	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CXB48_RS04930	COG1127	ABC transporter
CXB48_RS04935	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CXB48_RS04940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CXB48_RS04965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CXB48_RS04970	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CXB48_RS04985	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CXB48_RS04990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXB48_RS05000	COG0175	sulfate reduction
CXB48_RS05010	COG1131	(ABC) transporter
CXB48_RS05040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CXB48_RS05045	COG0237	dephospho-CoA kinase activity
CXB48_RS05060	COG0667	Aldo Keto reductase
CXB48_RS05065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CXB48_RS05070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CXB48_RS05075	COG0723	plastoquinol--plastocyanin reductase activity
CXB48_RS05080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CXB48_RS05085	COG2857	Cytochrome c1
CXB48_RS05090	COG0625	glutathione transferase activity
CXB48_RS05095	COG2969	positive regulation of protein catabolic process
CXB48_RS05100	COG2823	Periplasmic or secreted lipoprotein
CXB48_RS05105	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CXB48_RS05110	COG0792	nuclease activity
CXB48_RS05135	COG0275	rRNA processing
CXB48_RS05150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXB48_RS05155	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CXB48_RS05160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CXB48_RS05165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CXB48_RS05170	COG0772	Belongs to the SEDS family
CXB48_RS05175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CXB48_RS05180	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXB48_RS05185	COG1181	Belongs to the D-alanine--D-alanine ligase family
CXB48_RS05250	COG1285	pathogenesis
CXB48_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS05280	COG0659	secondary active sulfate transmembrane transporter activity
CXB48_RS05300	COG3344	reverse transcriptase
CXB48_RS05345	COG0840	transmembrane signaling receptor activity
CXB48_RS05350	COG0501	Belongs to the peptidase M48B family
CXB48_RS05360	COG2119	membrane
CXB48_RS05365	COG2813	Specifically methylates the guanine in position
CXB48_RS05370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CXB48_RS05375	COG1280	lysine exporter protein (LysE YggA)
CXB48_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
CXB48_RS05385	COG0784	Response regulator, receiver
CXB48_RS05385	COG4191	Histidine kinase
CXB48_RS05390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXB48_RS05395	COG2885	chlorophyll binding
CXB48_RS05400	COG2205	protein histidine kinase activity
CXB48_RS05400	COG0784	Response regulator, receiver
CXB48_RS05410	COG0204	Acyl-transferase
CXB48_RS05420	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CXB48_RS05430	COG0386	Belongs to the glutathione peroxidase family
CXB48_RS05435	COG1309	transcriptional regulator
CXB48_RS05445	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
CXB48_RS05460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXB48_RS05465	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS05505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXB48_RS05510	COG0693	protein deglycase activity
CXB48_RS05515	COG4628	conserved protein (DUF2132)
CXB48_RS05535	COG0469	pyruvate kinase activity
CXB48_RS05560	COG0714	Associated with various cellular activities
CXB48_RS05585	COG2925	Exonuclease
CXB48_RS05595	COG0788	formyltetrahydrofolate deformylase activity
CXB48_RS05605	COG0433	COG0433 Predicted ATPase
CXB48_RS05620	COG3022	response to hydroperoxide
CXB48_RS05630	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CXB48_RS05635	COG0315	cyclic pyranopterin monophosphate synthase activity
CXB48_RS05640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CXB48_RS05655	COG0400	carboxylic ester hydrolase activity
CXB48_RS05660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CXB48_RS05665	COG4597	amino acid ABC transporter
CXB48_RS05670	COG0765	amino acid transport
CXB48_RS05675	COG1126	abc transporter atp-binding protein
CXB48_RS05680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CXB48_RS05680	COG0047	phosphoribosylformylglycinamidine synthase activity
CXB48_RS05690	COG3034	peptidoglycan biosynthetic process
CXB48_RS05715	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CXB48_RS05720	COG4536	flavin adenine dinucleotide binding
CXB48_RS05725	COG4137	Cytochrome C assembly protein
CXB48_RS05730	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CXB48_RS05735	COG0228	four-way junction DNA binding
CXB48_RS05740	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CXB48_RS05745	COG0336	Belongs to the RNA methyltransferase TrmD family
CXB48_RS05750	COG0335	large ribosomal subunit rRNA binding
CXB48_RS05765	COG3791	Glutathione-dependent formaldehyde-activating
CXB48_RS05780	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXB48_RS05785	COG0418	dihydroorotase activity
CXB48_RS05795	COG0137	argininosuccinate synthase activity
CXB48_RS05800	COG0346	lactoylglutathione lyase activity
CXB48_RS05810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CXB48_RS05820	COG4659	FMN binding
CXB48_RS05825	COG4658	electron transport chain
CXB48_RS05835	COG2878	Part of a membrane complex involved in electron transport
CXB48_RS05840	COG4657	Part of a membrane complex involved in electron transport
CXB48_RS05855	COG1024	Enoyl-CoA hydratase
CXB48_RS05865	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CXB48_RS05880	COG0354	folic acid binding
CXB48_RS05920	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CXB48_RS05925	COG0481	GTPase activity
CXB48_RS05940	COG0571	ribonuclease III activity
CXB48_RS05950	COG1381	Involved in DNA repair and RecF pathway recombination
CXB48_RS05955	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CXB48_RS05965	COG0583	DNA-binding transcription factor activity
CXB48_RS05975	COG0500	methyltransferase
CXB48_RS05980	COG2226	methyltransferase
CXB48_RS05990	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXB48_RS06005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXB48_RS06020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXB48_RS06030	COG0583	DNA-binding transcription factor activity
CXB48_RS06035	COG3485	protocatechuate 3,4-dioxygenase
CXB48_RS06040	COG3485	protocatechuate 3,4-dioxygenase
CXB48_RS06045	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXB48_RS06050	COG0679	Auxin Efflux Carrier
CXB48_RS06055	COG1414	Transcriptional regulator
CXB48_RS06060	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CXB48_RS06065	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CXB48_RS06080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXB48_RS06085	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CXB48_RS06105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXB48_RS06105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CXB48_RS06110	COG0489	protein tyrosine kinase activity
CXB48_RS06115	COG3344	reverse transcriptase
CXB48_RS06120	COG1278	Cold shock
CXB48_RS06125	COG0717	Belongs to the dCTP deaminase family
CXB48_RS06130	COG3005	denitrification pathway
CXB48_RS06140	COG0243	molybdopterin cofactor binding
CXB48_RS06150	COG4459	periplasmic nitrate reductase
CXB48_RS06155	COG2814	Major facilitator Superfamily
CXB48_RS06180	COG0037	tRNA processing
CXB48_RS06185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXB48_RS06190	COG2818	Glycosylase
CXB48_RS06220	COG4890	Cyd operon protein YbgT
CXB48_RS06235	COG0791	NLP P60 protein
CXB48_RS06240	COG0791	NLP P60 protein
CXB48_RS06270	COG1797	cobyrinic acid a,c-diamide synthase activity
CXB48_RS06275	COG0778	Nitroreductase
CXB48_RS06285	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CXB48_RS06295	COG1492	cobalamin metabolic process
CXB48_RS06315	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CXB48_RS06320	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXB48_RS06325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXB48_RS06365	COG0251	oxidation-reduction process
CXB48_RS06375	COG2223	nitrite transmembrane transporter activity
CXB48_RS06390	COG4657	Part of a membrane complex involved in electron transport
CXB48_RS06400	COG4656	Part of a membrane complex involved in electron transport
CXB48_RS06445	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
CXB48_RS06510	COG3411	Ferredoxin
CXB48_RS06620	COG2067	long-chain fatty acid transport protein
CXB48_RS06635	COG3100	YcgL domain-containing protein
CXB48_RS06645	COG2983	Belongs to the UPF0260 family
CXB48_RS06660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CXB48_RS06665	COG0527	aspartate kinase activity
CXB48_RS06670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CXB48_RS06695	COG2239	Acts as a magnesium transporter
CXB48_RS06700	COG3630	sodium ion export across plasma membrane
CXB48_RS06705	COG5016	pyruvate
CXB48_RS06705	COG0511	ligase activity, forming carbon-carbon bonds
CXB48_RS06710	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CXB48_RS06740	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
CXB48_RS06760	COG0784	Response regulator, receiver
CXB48_RS06760	COG0835	chemotaxis
CXB48_RS06765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CXB48_RS06770	COG1815	bacterial-type flagellum-dependent cell motility
CXB48_RS06790	COG4787	bacterial-type flagellum-dependent cell motility
CXB48_RS06795	COG4786	Flagellar basal body rod
CXB48_RS06800	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CXB48_RS06805	COG1706	bacterial-type flagellum-dependent cell motility
CXB48_RS06815	COG1256	bacterial-type flagellum assembly
CXB48_RS06825	COG1555	photosystem II stabilization
CXB48_RS06850	COG2200	EAL domain
CXB48_RS06865	COG1362	aminopeptidase activity
CXB48_RS06875	COG0564	pseudouridine synthase activity
CXB48_RS06880	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CXB48_RS06885	COG2894	cell division
CXB48_RS06890	COG0850	regulation of cytokinetic process
CXB48_RS06895	COG1560	Kdo2-lipid A biosynthetic process
CXB48_RS06905	COG2853	Lipoprotein
CXB48_RS06920	COG3162	membrane
CXB48_RS06925	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXB48_RS06945	COG3089	Belongs to the UPF0270 family
CXB48_RS06955	COG1363	Peptidase, m42
CXB48_RS06960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CXB48_RS06960	COG0189	ligase activity
CXB48_RS06965	COG0367	asparagine synthase
CXB48_RS06975	COG4935	Belongs to the peptidase S8 family
CXB48_RS06975	COG1404	Belongs to the peptidase S8 family
CXB48_RS06985	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CXB48_RS06995	COG4221	oxidoreductase activity
CXB48_RS07005	COG1201	RNA secondary structure unwinding
CXB48_RS07040	COG2133	pyrroloquinoline quinone binding
CXB48_RS07045	COG4993	Dehydrogenase
CXB48_RS07050	COG2996	Protein conserved in bacteria
CXB48_RS07065	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXB48_RS07150	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXB48_RS07195	COG0582	viral genome integration into host DNA
CXB48_RS07210	COG3292	Two component regulator propeller
CXB48_RS07210	COG2205	protein histidine kinase activity
CXB48_RS07210	COG0745	RESPONSE REGULATOR receiver
CXB48_RS07240	COG1295	ribonuclease BN
CXB48_RS07245	COG0438	transferase activity, transferring glycosyl groups
CXB48_RS07265	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CXB48_RS07270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CXB48_RS07280	COG1546	Belongs to the CinA family
CXB48_RS07285	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CXB48_RS07290	COG2137	regulation of response to DNA damage stimulus
CXB48_RS07300	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXB48_RS07305	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
CXB48_RS07315	COG3148	PFAM DTW domain containing protein
CXB48_RS07320	COG0697	spore germination
CXB48_RS07330	COG0583	DNA-binding transcription factor activity
CXB48_RS07340	COG3012	SEC-C Motif Domain Protein
CXB48_RS07360	COG1199	ATP-dependent helicase activity
CXB48_RS07365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
CXB48_RS07375	COG0259	pyridoxamine-phosphate oxidase activity
CXB48_RS07390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXB48_RS07390	COG2111	Na H antiporter
CXB48_RS07395	COG1006	Multisubunit Na H antiporter MnhC subunit
CXB48_RS07400	COG0651	ATP synthesis coupled electron transport
CXB48_RS07405	COG1863	multisubunit Na H antiporter MnhE subunit
CXB48_RS07410	COG2212	antiporter activity
CXB48_RS07415	COG1320	monovalent cation:proton antiporter activity
CXB48_RS07420	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CXB48_RS07425	COG0024	Methionine aminopeptidase
CXB48_RS07430	COG0052	Belongs to the universal ribosomal protein uS2 family
CXB48_RS07435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CXB48_RS07440	COG0528	UMP kinase activity
CXB48_RS07445	COG0233	cytoplasmic translational termination
CXB48_RS07450	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CXB48_RS07460	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CXB48_RS07470	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXB48_RS07480	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXB48_RS07485	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXB48_RS07490	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXB48_RS07495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXB48_RS07500	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CXB48_RS07510	COG0825	malonyl-CoA metabolic process
CXB48_RS07515	COG0037	tRNA processing
CXB48_RS07520	COG0504	CTP synthase activity
CXB48_RS07525	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CXB48_RS07540	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CXB48_RS07555	COG0583	DNA-binding transcription factor activity
CXB48_RS07560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CXB48_RS07565	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXB48_RS07570	COG1902	pentaerythritol trinitrate reductase activity
CXB48_RS07580	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CXB48_RS07585	COG0585	pseudouridine synthase activity
CXB48_RS07590	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CXB48_RS07595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CXB48_RS07645	COG0589	response to stress
CXB48_RS07655	COG0217	transcriptional regulatory protein
CXB48_RS07665	COG2258	MOSC domain
CXB48_RS07680	COG0004	ammonium transporteR
CXB48_RS07685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXB48_RS07730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXB48_RS07735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXB48_RS07745	COG1283	sodium-dependent phosphate transmembrane transporter activity
CXB48_RS07760	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CXB48_RS07780	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXB48_RS07795	COG0826	peptidase U32
CXB48_RS07825	COG0789	Transcriptional regulator
CXB48_RS07870	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CXB48_RS07875	COG2226	methyltransferase
CXB48_RS07885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CXB48_RS07890	COG0583	DNA-binding transcription factor activity
CXB48_RS07900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CXB48_RS07910	COG0745	RESPONSE REGULATOR receiver
CXB48_RS07915	COG2205	protein histidine kinase activity
CXB48_RS07925	COG0668	transmembrane transport
CXB48_RS07970	COG2988	succinylglutamate desuccinylase activity
CXB48_RS07975	COG1131	(ABC) transporter
CXB48_RS07980	COG0842	Transport permease protein
CXB48_RS07985	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXB48_RS07985	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CXB48_RS07995	COG3039	Transposase
CXB48_RS08000	COG2853	Lipoprotein
CXB48_RS08010	COG0745	RESPONSE REGULATOR receiver
CXB48_RS08020	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CXB48_RS08040	COG3012	SEC-C Motif Domain Protein
CXB48_RS08045	COG4372	Transposase
CXB48_RS08050	COG3436	PFAM IS66 Orf2 family protein
CXB48_RS08075	COG0385	Bile acid
CXB48_RS08085	COG0778	Nitroreductase
CXB48_RS08100	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CXB48_RS08105	COG1116	anion transmembrane transporter activity
CXB48_RS08110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXB48_RS08115	COG1116	anion transmembrane transporter activity
CXB48_RS08115	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXB48_RS08120	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXB48_RS08155	COG1196	nuclear chromosome segregation
CXB48_RS08210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXB48_RS08265	COG0789	Transcriptional regulator
CXB48_RS08280	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CXB48_RS08285	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CXB48_RS08300	COG4372	Transposase
CXB48_RS08350	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXB48_RS08385	COG2814	Major facilitator Superfamily
CXB48_RS08390	COG4948	Mandelate Racemase Muconate Lactonizing
CXB48_RS08395	COG4829	muconolactone delta-isomerase
CXB48_RS08400	COG3485	protocatechuate 3,4-dioxygenase
CXB48_RS08405	COG3135	benzoate transporter
CXB48_RS08415	COG4372	Transposase
CXB48_RS08465	COG0720	synthase
CXB48_RS08470	COG2056	Na+-H+ antiporter family
CXB48_RS08475	COG0628	permease
CXB48_RS08500	COG2153	protein acetylation
CXB48_RS08505	COG2850	peptidyl-arginine hydroxylation
CXB48_RS08515	COG2915	High frequency lysogenization protein hflD homolog
CXB48_RS08520	COG0482	sulfurtransferase activity
CXB48_RS08540	COG1278	Cold shock
CXB48_RS08545	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CXB48_RS08550	COG0542	response to heat
CXB48_RS08565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CXB48_RS08570	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CXB48_RS08575	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CXB48_RS08580	COG0492	ferredoxin-NADP+ reductase activity
CXB48_RS08590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CXB48_RS08595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CXB48_RS08600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CXB48_RS08605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CXB48_RS08610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXB48_RS08610	COG1648	precorrin-2 dehydrogenase activity
CXB48_RS08630	COG1131	(ABC) transporter
CXB48_RS08650	COG0840	transmembrane signaling receptor activity
CXB48_RS08700	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CXB48_RS08710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXB48_RS08740	COG4172	Belongs to the ABC transporter superfamily
CXB48_RS08745	COG4239	(ABC) transporter, permease
CXB48_RS08750	COG4174	ABC transporter (Permease)
CXB48_RS08760	COG4166	transmembrane transport
CXB48_RS08770	COG0741	lytic transglycosylase activity
CXB48_RS08770	COG1388	LysM domain
CXB48_RS08775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CXB48_RS08785	COG0328	RNA-DNA hybrid ribonuclease activity
CXB48_RS08790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXB48_RS08800	COG1024	Enoyl-CoA hydratase
CXB48_RS08810	COG2816	NAD+ diphosphatase activity
CXB48_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS08845	COG0616	signal peptide processing
CXB48_RS08850	COG0604	alcohol dehydrogenase
CXB48_RS08870	COG0071	Belongs to the small heat shock protein (HSP20) family
CXB48_RS08885	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXB48_RS08890	COG2223	nitrite transmembrane transporter activity
CXB48_RS08915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CXB48_RS08915	COG2755	lipolytic protein G-D-S-L family
CXB48_RS08935	COG0316	Belongs to the HesB IscA family
CXB48_RS08935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CXB48_RS08940	COG2201	protein-glutamate methylesterase activity
CXB48_RS08945	COG3706	GGDEF domain
CXB48_RS08960	COG2323	membrane
CXB48_RS08975	COG0840	transmembrane signaling receptor activity
CXB48_RS08980	COG1968	undecaprenyl-diphosphatase activity
CXB48_RS08985	COG0488	(ABC) transporter
CXB48_RS09010	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXB48_RS09015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CXB48_RS09025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXB48_RS09030	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CXB48_RS09035	COG1609	Transcriptional regulator
CXB48_RS09055	COG1070	Carbohydrate kinase
CXB48_RS09075	COG1175	transmembrane transport
CXB48_RS09095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CXB48_RS09110	COG0729	surface antigen
CXB48_RS09115	COG2911	Protein conserved in bacteria
CXB48_RS09120	COG1115	amino acid carrier protein
CXB48_RS09135	COG0728	peptidoglycan biosynthetic process
CXB48_RS09145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS09195	COG0604	alcohol dehydrogenase
CXB48_RS09195	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS09195	COG3321	synthase
CXB48_RS09200	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS09215	COG0243	molybdopterin cofactor binding
CXB48_RS09215	COG3383	formate dehydrogenase (NAD+) activity
CXB48_RS09220	COG0243	molybdopterin cofactor binding
CXB48_RS09220	COG3383	formate dehydrogenase (NAD+) activity
CXB48_RS09225	COG0437	4 iron, 4 sulfur cluster binding
CXB48_RS09230	COG2864	formate dehydrogenase
CXB48_RS09245	COG0366	Alpha amylase catalytic
CXB48_RS09250	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXB48_RS09255	COG0392	lysyltransferase activity
CXB48_RS09260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CXB48_RS09265	COG3568	Endonuclease Exonuclease Phosphatase
CXB48_RS09280	COG0583	DNA-binding transcription factor activity
CXB48_RS09285	COG3384	dioxygenase
CXB48_RS09295	COG0739	heme binding
CXB48_RS09320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CXB48_RS09325	COG0297	glycogen (starch) synthase activity
CXB48_RS09330	COG1058	Belongs to the CinA family
CXB48_RS09330	COG1546	Belongs to the CinA family
CXB48_RS09335	COG3264	Mechanosensitive ion channel
CXB48_RS09335	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CXB48_RS09340	COG3685	Protein conserved in bacteria
CXB48_RS09365	COG0028	Belongs to the TPP enzyme family
CXB48_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS09375	COG0723	plastoquinol--plastocyanin reductase activity
CXB48_RS09390	COG0583	DNA-binding transcription factor activity
CXB48_RS09400	COG1566	PFAM secretion protein HlyD family protein
CXB48_RS09425	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CXB48_RS09475	COG5642	Protein of unknown function (DUF2384)
CXB48_RS09500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXB48_RS09505	COG1742	UPF0060 membrane protein
CXB48_RS09515	COG0431	NADPH-dependent FMN reductase
CXB48_RS09520	COG0640	Transcriptional regulator
CXB48_RS09525	COG2072	flavoprotein involved in K transport
CXB48_RS09530	COG0798	PFAM Bile acid sodium symporter
CXB48_RS09585	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS09590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXB48_RS09605	COG5002	protein histidine kinase activity
CXB48_RS09620	COG0535	radical SAM domain protein
CXB48_RS09630	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CXB48_RS09635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CXB48_RS09680	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXB48_RS09685	COG0167	dihydroorotate dehydrogenase activity
CXB48_RS09700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CXB48_RS09705	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CXB48_RS09715	COG0544	peptidyl-prolyl cis-trans isomerase activity
CXB48_RS09725	COG2186	Transcriptional regulator
CXB48_RS09745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CXB48_RS09750	COG0215	cysteine-tRNA ligase activity
CXB48_RS09755	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXB48_RS09760	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CXB48_RS09765	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CXB48_RS09800	COG0668	transmembrane transport
CXB48_RS09815	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CXB48_RS09830	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CXB48_RS09845	COG0372	Belongs to the citrate synthase family
CXB48_RS09855	COG1802	Transcriptional regulator
CXB48_RS09880	COG0560	Phosphoserine phosphatase
CXB48_RS09895	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CXB48_RS09900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CXB48_RS09920	COG3344	reverse transcriptase
CXB48_RS09940	COG4181	ATPase activity
CXB48_RS09945	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CXB48_RS09965	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CXB48_RS09970	COG0084	hydrolase, TatD family'
CXB48_RS09985	COG3842	ATPase activity
CXB48_RS10000	COG0439	Biotin carboxylase
CXB48_RS10015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXB48_RS10025	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS10045	COG1335	isochorismatase
CXB48_RS10055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXB48_RS10060	COG1116	anion transmembrane transporter activity
CXB48_RS10065	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXB48_RS10070	COG0174	glutamine synthetase
CXB48_RS10120	COG2920	part of a sulfur-relay system
CXB48_RS10125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CXB48_RS10130	COG0435	Glutathione S-transferase
CXB48_RS10135	COG0784	Response regulator, receiver
CXB48_RS10135	COG2205	protein histidine kinase activity
CXB48_RS10150	COG1025	Belongs to the peptidase M16 family
CXB48_RS10155	COG0789	Transcriptional regulator
CXB48_RS10165	COG0302	gtp cyclohydrolase
CXB48_RS10170	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CXB48_RS10190	COG1366	Belongs to the anti-sigma-factor antagonist family
CXB48_RS10200	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CXB48_RS10205	COG1090	epimerase
CXB48_RS10210	COG3272	Protein of unknown function (DUF1722)
CXB48_RS10215	COG0789	Transcriptional regulator
CXB48_RS10220	COG0415	Belongs to the DNA photolyase family
CXB48_RS10230	COG4221	oxidoreductase activity
CXB48_RS10245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CXB48_RS10250	COG0840	transmembrane signaling receptor activity
CXB48_RS10265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXB48_RS10265	COG2146	nitrite reductase [NAD(P)H] activity
CXB48_RS10270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXB48_RS10270	COG2146	nitrite reductase [NAD(P)H] activity
CXB48_RS10280	COG0515	serine threonine protein kinase
CXB48_RS10285	COG0210	DNA helicase
CXB48_RS10330	COG5002	protein histidine kinase activity
CXB48_RS10330	COG3447	MASE1 domain protein
CXB48_RS10330	COG5001	Diguanylate cyclase
CXB48_RS10345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CXB48_RS10365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXB48_RS10370	COG0784	Response regulator, receiver
CXB48_RS10370	COG4191	Histidine kinase
CXB48_RS10385	COG4991	sh3 domain protein
CXB48_RS10400	COG2207	Transcriptional regulator
CXB48_RS10415	COG0058	SHG alpha-glucan phosphorylase activity
CXB48_RS10445	COG1024	Enoyl-CoA hydratase
CXB48_RS10450	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS10460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXB48_RS10465	COG0318	PFAM AMP-dependent synthetase and ligase
CXB48_RS10470	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS10490	COG1238	metal cluster binding
CXB48_RS10515	COG0714	Associated with various cellular activities
CXB48_RS10525	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CXB48_RS10530	COG0709	Synthesizes selenophosphate from selenide and ATP
CXB48_RS10540	COG0628	permease
CXB48_RS10575	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CXB48_RS10580	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CXB48_RS10590	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CXB48_RS10620	COG0326	Molecular chaperone. Has ATPase activity
CXB48_RS10655	COG0045	succinate-CoA ligase (ADP-forming) activity
CXB48_RS10675	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CXB48_RS10680	COG1053	succinate dehydrogenase
CXB48_RS10685	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CXB48_RS10690	COG2009	succinate dehydrogenase
CXB48_RS10740	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXB48_RS10745	COG3115	cell septum assembly
CXB48_RS10755	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CXB48_RS10760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXB48_RS10775	COG2010	Cytochrome c
CXB48_RS10775	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXB48_RS10780	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXB48_RS10800	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
CXB48_RS10810	COG0840	transmembrane signaling receptor activity
CXB48_RS10830	COG2010	Cytochrome c
CXB48_RS10835	COG3278	Belongs to the heme-copper respiratory oxidase family
CXB48_RS10850	COG2010	Cytochrome c
CXB48_RS10880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CXB48_RS10890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CXB48_RS10895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CXB48_RS10910	COG0573	inorganic phosphate transmembrane transporter activity
CXB48_RS10925	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CXB48_RS10930	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CXB48_RS10940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CXB48_RS10970	COG1902	pentaerythritol trinitrate reductase activity
CXB48_RS10970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CXB48_RS10990	COG1294	oxidase, subunit
CXB48_RS10995	COG1271	oxidase subunit
CXB48_RS11020	COG2814	Major facilitator Superfamily
CXB48_RS11025	COG0655	NAD(P)H dehydrogenase (quinone) activity
CXB48_RS11040	COG0254	rRNA binding
CXB48_RS11045	COG4771	TonB-dependent receptor
CXB48_RS11075	COG0789	Transcriptional regulator
CXB48_RS11110	COG1286	toxin biosynthetic process
CXB48_RS11115	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CXB48_RS11120	COG0285	dihydrofolate synthase activity
CXB48_RS11125	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CXB48_RS11130	COG0135	phosphoribosylanthranilate isomerase activity
CXB48_RS11160	COG0066	3-isopropylmalate dehydratase activity
CXB48_RS11165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CXB48_RS11180	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS11185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CXB48_RS11245	COG0250	Participates in transcription elongation, termination and antitermination
CXB48_RS11275	COG0297	glycogen (starch) synthase activity
CXB48_RS11300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXB48_RS11305	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CXB48_RS11310	COG1012	belongs to the aldehyde dehydrogenase family
CXB48_RS11315	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CXB48_RS11320	COG0133	tryptophan synthase activity
CXB48_RS11340	COG0653	protein targeting
CXB48_RS11405	COG0183	Belongs to the thiolase family
CXB48_RS11410	COG1250	3-hydroxyacyl-CoA dehydrogenase
CXB48_RS11410	COG1024	Enoyl-CoA hydratase
CXB48_RS11415	COG1770	oligopeptidase
CXB48_RS11425	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CXB48_RS11460	COG0583	DNA-binding transcription factor activity
CXB48_RS11465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CXB48_RS11470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXB48_RS11500	COG2301	Belongs to the HpcH HpaI aldolase family
CXB48_RS11510	COG2079	MmgE PrpD family protein
CXB48_RS11520	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS11525	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
CXB48_RS11530	COG0583	DNA-binding transcription factor activity
CXB48_RS11555	COG0840	transmembrane signaling receptor activity
CXB48_RS11560	COG3039	Transposase
CXB48_RS11575	COG1054	Belongs to the UPF0176 family
CXB48_RS11580	COG0271	Belongs to the BolA IbaG family
CXB48_RS11590	COG0114	fumarate hydratase activity
CXB48_RS11600	COG0784	Response regulator, receiver
CXB48_RS11600	COG4191	Histidine kinase
CXB48_RS11635	COG0402	S-adenosylhomocysteine deaminase activity
CXB48_RS11640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CXB48_RS11645	COG0546	phosphoglycolate phosphatase activity
CXB48_RS11650	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS11660	COG0800	Aldolase
CXB48_RS11685	COG2840	Smr protein MutS2
CXB48_RS11695	COG0625	glutathione transferase activity
CXB48_RS11700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXB48_RS11710	COG3344	reverse transcriptase
CXB48_RS11720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CXB48_RS11725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CXB48_RS11735	COG1605	Chorismate mutase
CXB48_RS11735	COG0077	Prephenate dehydratase
CXB48_RS11740	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CXB48_RS11750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CXB48_RS11765	COG0587	DNA-directed DNA polymerase activity
CXB48_RS11795	COG4372	Transposase
CXB48_RS11860	COG0776	regulation of translation
CXB48_RS11865	COG0072	phenylalanine-tRNA ligase activity
CXB48_RS11870	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CXB48_RS11875	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CXB48_RS11880	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CXB48_RS11890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CXB48_RS11900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXB48_RS11975	COG3171	Protein conserved in bacteria
CXB48_RS11980	COG2027	D-alanyl-D-alanine carboxypeptidase
CXB48_RS11985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXB48_RS11985	COG0116	Belongs to the methyltransferase superfamily
CXB48_RS11990	COG3130	regulation of translation
CXB48_RS11995	COG0167	dihydroorotate dehydrogenase activity
CXB48_RS12015	COG0714	Associated with various cellular activities
CXB48_RS12045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXB48_RS12050	COG3707	response regulator
CXB48_RS12070	COG2223	nitrite transmembrane transporter activity
CXB48_RS12075	COG2815	serine threonine protein kinase
CXB48_RS12075	COG0515	serine threonine protein kinase
CXB48_RS12085	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CXB48_RS12090	COG2146	nitrite reductase [NAD(P)H] activity
CXB48_RS12095	COG0243	molybdopterin cofactor binding
CXB48_RS12115	COG0308	aminopeptidase N
CXB48_RS12135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CXB48_RS12140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CXB48_RS12155	COG0730	response to heat
CXB48_RS12170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXB48_RS12195	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
CXB48_RS12210	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CXB48_RS12225	COG4580	involved in the transport of maltose and maltodextrins
CXB48_RS12230	COG3842	ATPase activity
CXB48_RS12235	COG0395	ABC-type sugar transport system, permease component
CXB48_RS12240	COG1175	transmembrane transport
CXB48_RS12245	COG1653	transport
CXB48_RS12270	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CXB48_RS12280	COG0180	Tryptophanyl-tRNA synthetase
CXB48_RS12285	COG0009	L-threonylcarbamoyladenylate synthase
CXB48_RS12290	COG0613	PHP domain protein
CXB48_RS12295	COG2350	Protein conserved in bacteria
CXB48_RS12305	COG0745	RESPONSE REGULATOR receiver
CXB48_RS12320	COG0778	Nitroreductase
CXB48_RS12325	COG0727	PFAM Uncharacterised protein family (UPF0153)
CXB48_RS12330	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CXB48_RS12335	COG2354	Protein conserved in bacteria
CXB48_RS12370	COG1752	Esterase of the alpha-beta hydrolase superfamily
CXB48_RS12380	COG0514	ATP-dependent DNA helicase (RecQ)
CXB48_RS12390	COG2832	Protein of unknown function (DUF454)
CXB48_RS12405	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CXB48_RS12415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CXB48_RS12425	COG0542	response to heat
CXB48_RS12445	COG0121	glutamine amidotransferase
CXB48_RS12455	COG0589	response to stress
CXB48_RS12465	COG0488	(ABC) transporter
CXB48_RS12470	COG0741	lytic transglycosylase activity
CXB48_RS12475	COG3217	Mosc domain protein beta barrel domain protein
CXB48_RS12475	COG0633	Ferredoxin
CXB48_RS12480	COG3437	response regulator, receiver
CXB48_RS12490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXB48_RS12495	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXB48_RS12500	COG0489	protein tyrosine kinase activity
CXB48_RS12500	COG3206	protein involved in exopolysaccharide biosynthesis
CXB48_RS12505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CXB48_RS12545	COG0183	Belongs to the thiolase family
CXB48_RS12555	COG2977	Belongs to the P-Pant transferase superfamily
CXB48_RS12570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CXB48_RS12575	COG0110	maltose O-acetyltransferase activity
CXB48_RS12580	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CXB48_RS12585	COG0438	transferase activity, transferring glycosyl groups
CXB48_RS12600	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CXB48_RS12605	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CXB48_RS12620	COG0489	protein tyrosine kinase activity
CXB48_RS12620	COG3206	protein involved in exopolysaccharide biosynthesis
CXB48_RS12625	COG0776	regulation of translation
CXB48_RS12630	COG3344	reverse transcriptase
CXB48_RS12645	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CXB48_RS12650	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CXB48_RS12655	COG0471	metal ion transport
CXB48_RS12660	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CXB48_RS12675	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
CXB48_RS12700	COG4591	ABC-type transport system involved in lipoprotein release permease component
CXB48_RS12705	COG1136	(ABC) transporter
CXB48_RS12725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXB48_RS12745	COG0640	Transcriptional regulator
CXB48_RS12780	COG0386	Belongs to the glutathione peroxidase family
CXB48_RS12785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXB48_RS12790	COG0436	Aminotransferase
CXB48_RS12800	COG0501	Belongs to the peptidase M48B family
CXB48_RS12810	COG0500	methyltransferase
CXB48_RS12860	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CXB48_RS12890	COG2257	FlhB HrpN YscU SpaS Family
CXB48_RS12905	COG0835	chemotaxis
CXB48_RS12915	COG1192	Involved in chromosome partitioning
CXB48_RS12920	COG1360	Flagellar Motor Protein
CXB48_RS12925	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CXB48_RS12930	COG2201	protein-glutamate methylesterase activity
CXB48_RS12935	COG2198	Histidine kinase
CXB48_RS12935	COG0643	Histidine kinase
CXB48_RS12935	COG0784	Response regulator, receiver
CXB48_RS12940	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CXB48_RS12970	COG2032	superoxide dismutase activity
CXB48_RS12985	COG1987	bacterial-type flagellum assembly
CXB48_RS13025	COG0745	RESPONSE REGULATOR receiver
CXB48_RS13060	COG1677	Flagellar hook-basal body complex protein FliE
CXB48_RS13065	COG3135	benzoate transporter
CXB48_RS13075	COG2130	NADP-dependent
CXB48_RS13090	COG3300	MHYT domain
CXB48_RS13090	COG5001	Diguanylate cyclase
CXB48_RS13100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXB48_RS13160	COG1113	amino acid transport
CXB48_RS13165	COG0084	hydrolase, TatD family'
CXB48_RS13180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CXB48_RS13185	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CXB48_RS13195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CXB48_RS13200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXB48_RS13215	COG0416	fatty acid biosynthetic process
CXB48_RS13220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CXB48_RS13230	COG0424	maF-like protein
CXB48_RS13235	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CXB48_RS13235	COG0616	signal peptide processing
CXB48_RS13255	COG1530	ribonuclease E activity
CXB48_RS13260	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CXB48_RS13265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CXB48_RS13270	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CXB48_RS13275	COG2835	tetraacyldisaccharide 4'-kinase activity
CXB48_RS13280	COG1663	tetraacyldisaccharide 4'-kinase activity
CXB48_RS13290	COG0811	peptide transport
CXB48_RS13295	COG0658	competence protein
CXB48_RS13295	COG2333	competence protein COMEC
CXB48_RS13310	COG1136	(ABC) transporter
CXB48_RS13315	COG4591	ABC-type transport system involved in lipoprotein release permease component
CXB48_RS13330	COG0584	glycerophosphoryl diester phosphodiesterase
CXB48_RS13335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CXB48_RS13345	COG1477	protein flavinylation
CXB48_RS13355	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
CXB48_RS13370	COG1805	sodium ion transport
CXB48_RS13385	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CXB48_RS13395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXB48_RS13410	COG1793	dna ligase
CXB48_RS13415	COG1201	RNA secondary structure unwinding
CXB48_RS13440	COG3956	TIGRFAM MazG family protein
CXB48_RS13445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CXB48_RS13450	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CXB48_RS13465	COG2860	membrane
CXB48_RS13470	COG0784	Response regulator, receiver
CXB48_RS13470	COG5002	protein histidine kinase activity
CXB48_RS13470	COG2205	protein histidine kinase activity
CXB48_RS13475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CXB48_RS13475	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CXB48_RS13495	COG0583	DNA-binding transcription factor activity
CXB48_RS13510	COG0513	Belongs to the DEAD box helicase family
CXB48_RS13550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CXB48_RS13555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CXB48_RS13560	COG2226	methyltransferase
CXB48_RS13585	COG1131	(ABC) transporter
CXB48_RS13615	COG2937	Belongs to the GPAT DAPAT family
CXB48_RS13620	COG0456	acetyltransferase
CXB48_RS13635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CXB48_RS13660	COG2132	Multicopper oxidase
CXB48_RS13685	COG0456	acetyltransferase
CXB48_RS13690	COG0655	NAD(P)H dehydrogenase (quinone) activity
CXB48_RS13705	COG2943	transferase activity, transferring hexosyl groups
CXB48_RS13715	COG1472	Belongs to the glycosyl hydrolase 3 family
CXB48_RS13725	COG1346	cytolysis
CXB48_RS13730	COG1380	Effector of murein hydrolase LrgA
CXB48_RS13735	COG0348	domain, Protein
CXB48_RS13740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXB48_RS13760	COG1309	transcriptional regulator
CXB48_RS13765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS13770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXB48_RS13975	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
CXB48_RS14090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CXB48_RS14095	COG3723	Recombinational DNA repair protein, rece pathway
CXB48_RS14150	COG0582	viral genome integration into host DNA
CXB48_RS14160	COG0742	ribosomal rna small subunit methyltransferase
CXB48_RS14185	COG0563	adenylate kinase activity
CXB48_RS14190	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CXB48_RS14230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CXB48_RS14245	COG1902	pentaerythritol trinitrate reductase activity
CXB48_RS14250	COG0243	molybdopterin cofactor binding
CXB48_RS14255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CXB48_RS14265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CXB48_RS14270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CXB48_RS14275	COG1984	allophanate hydrolase subunit 2
CXB48_RS14280	COG4336	lyase activity
CXB48_RS14285	COG1914	H( )-stimulated, divalent metal cation uptake system
CXB48_RS14310	COG0545	Peptidyl-prolyl cis-trans isomerase
CXB48_RS14325	COG2974	May be involved in recombination
CXB48_RS14330	COG2814	Major facilitator Superfamily
CXB48_RS14350	COG2205	protein histidine kinase activity
CXB48_RS14355	COG3174	membrane
CXB48_RS14390	COG0417	DNA replication proofreading
CXB48_RS14400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CXB48_RS14410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CXB48_RS14420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CXB48_RS14430	COG0425	Belongs to the sulfur carrier protein TusA family
CXB48_RS14440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CXB48_RS14445	COG0427	acetyl-CoA hydrolase
CXB48_RS14460	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CXB48_RS14465	COG0602	queuosine metabolic process
CXB48_RS14470	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CXB48_RS14475	COG2885	chlorophyll binding
CXB48_RS14480	COG0823	Involved in the tonB-independent uptake of proteins
CXB48_RS14500	COG0824	Thioesterase
CXB48_RS14505	COG2255	four-way junction helicase activity
CXB48_RS14510	COG0632	four-way junction helicase activity
CXB48_RS14515	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CXB48_RS14525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CXB48_RS14530	COG0783	Belongs to the Dps family
CXB48_RS14540	COG2900	Belongs to the SlyX family
CXB48_RS14585	COG0442	prolyl-tRNA aminoacylation
CXB48_RS14615	COG1295	ribonuclease BN
CXB48_RS14620	COG1393	Belongs to the ArsC family
CXB48_RS14635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CXB48_RS14640	COG0628	permease
CXB48_RS14650	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CXB48_RS14655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CXB48_RS14670	COG0436	Aminotransferase
CXB48_RS14685	COG1393	Belongs to the ArsC family
CXB48_RS14690	COG2171	N-acyltransferase activity
CXB48_RS14695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CXB48_RS14700	COG2166	iron-sulfur cluster assembly
CXB48_RS14710	COG3258	Cytochrome c
CXB48_RS14715	COG2863	cytochrome
CXB48_RS14725	COG3530	Putative quorum-sensing-regulated virulence factor
CXB48_RS14735	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CXB48_RS14745	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CXB48_RS14750	COG3932	Exopolysaccharide synthesis, ExoD
CXB48_RS14755	COG0583	DNA-binding transcription factor activity
CXB48_RS14760	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS14770	COG1280	lysine exporter protein (LysE YggA)
CXB48_RS14790	COG1462	curli production assembly transport component CsgG
CXB48_RS14810	COG1309	transcriptional regulator
CXB48_RS14815	COG0583	DNA-binding transcription factor activity
CXB48_RS14820	COG0189	ligase activity
CXB48_RS14820	COG4067	protein conserved in archaea
CXB48_RS14830	COG0116	Belongs to the methyltransferase superfamily
CXB48_RS14830	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXB48_RS14835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CXB48_RS14850	COG3321	synthase
CXB48_RS14850	COG0604	alcohol dehydrogenase
CXB48_RS14860	COG3284	Transcriptional regulator
CXB48_RS14875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CXB48_RS14880	COG1063	alcohol dehydrogenase
CXB48_RS14885	COG0022	dehydrogenase e1 component
CXB48_RS14890	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXB48_RS14895	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXB48_RS14925	COG0583	DNA-binding transcription factor activity
CXB48_RS14930	COG0625	glutathione transferase activity
CXB48_RS14955	COG0659	secondary active sulfate transmembrane transporter activity
CXB48_RS14965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CXB48_RS14975	COG1696	Membrane protein involved in D-alanine export
CXB48_RS14995	COG4372	Transposase
CXB48_RS15010	COG1280	lysine exporter protein (LysE YggA)
CXB48_RS15030	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CXB48_RS15040	COG4249	Peptidase C14 caspase catalytic subunit p20
CXB48_RS15045	COG1132	(ABC) transporter
CXB48_RS15085	COG0159	tryptophan synthase activity
CXB48_RS15100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXB48_RS15110	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CXB48_RS15120	COG4221	oxidoreductase activity
CXB48_RS15130	COG2207	Transcriptional regulator
CXB48_RS15135	COG3845	ABC transporter
CXB48_RS15140	COG4603	Belongs to the binding-protein-dependent transport system permease family
CXB48_RS15145	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXB48_RS15170	COG1301	dicarboxylic acid transport
CXB48_RS15180	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CXB48_RS15185	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CXB48_RS15195	COG0490	domain, Protein
CXB48_RS15195	COG0471	metal ion transport
CXB48_RS15205	COG2814	Major facilitator Superfamily
CXB48_RS15225	COG0596	Alpha beta hydrolase
CXB48_RS15225	COG0508	dehydrogenase complex catalyzes the overall conversion of
CXB48_RS15250	COG1279	arginine transmembrane transporter activity
CXB48_RS15265	COG0840	transmembrane signaling receptor activity
CXB48_RS15275	COG2733	membrane
CXB48_RS15280	COG1116	anion transmembrane transporter activity
CXB48_RS15295	COG0537	adenosine 5'-monophosphoramidase activity
CXB48_RS15305	COG2258	MOSC domain
CXB48_RS15320	COG3795	YCII-related domain
CXB48_RS15335	COG2851	Citrate transporter
CXB48_RS15345	COG1234	tRNA 3'-trailer cleavage
CXB48_RS15355	COG2267	carboxylic ester hydrolase activity
CXB48_RS15360	COG3257	ureidoglycine aminohydrolase activity
CXB48_RS15365	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CXB48_RS15370	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CXB48_RS15375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXB48_RS15380	COG0631	protein serine/threonine phosphatase activity
CXB48_RS15385	COG2815	serine threonine protein kinase
CXB48_RS15385	COG0515	serine threonine protein kinase
CXB48_RS15400	COG1643	Atp-dependent helicase
CXB48_RS15425	COG0318	PFAM AMP-dependent synthetase and ligase
CXB48_RS15430	COG2030	dehydratase
CXB48_RS15455	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CXB48_RS15465	COG0443	Heat shock 70 kDa protein
CXB48_RS15470	COG2271	Major facilitator Superfamily
CXB48_RS15475	COG3622	Belongs to the hyi family
CXB48_RS15480	COG2084	Dehydrogenase
CXB48_RS15485	COG1968	undecaprenyl-diphosphatase activity
CXB48_RS15495	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CXB48_RS15505	COG3639	organic phosphonate transmembrane transporter activity
CXB48_RS15510	COG3639	organic phosphonate transmembrane transporter activity
CXB48_RS15560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CXB48_RS15600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXB48_RS15605	COG0556	nucleotide-excision repair
CXB48_RS15625	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CXB48_RS15635	COG3842	ATPase activity
CXB48_RS15640	COG0590	tRNA wobble adenosine to inosine editing
CXB48_RS15645	COG2132	Multicopper oxidase
CXB48_RS15650	COG0519	Catalyzes the synthesis of GMP from XMP
CXB48_RS15650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CXB48_RS15665	COG1570	exodeoxyribonuclease VII activity
CXB48_RS15670	COG0739	heme binding
CXB48_RS15680	COG0668	transmembrane transport
CXB48_RS15695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXB48_RS15700	COG1064	alcohol dehydrogenase
CXB48_RS15710	COG2356	endonuclease I
CXB48_RS15715	COG3647	Membrane
CXB48_RS15725	COG2264	protein methyltransferase activity
CXB48_RS15740	COG0436	Aminotransferase
CXB48_RS15750	COG1160	GTP binding
CXB48_RS15760	COG2976	Protein conserved in bacteria
CXB48_RS15765	COG0124	histidyl-tRNA synthetase
CXB48_RS15770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CXB48_RS15785	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CXB48_RS15790	COG0105	UTP biosynthetic process
CXB48_RS15805	COG0443	Heat shock 70 kDa protein
CXB48_RS15810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CXB48_RS15815	COG0316	Belongs to the HesB IscA family
CXB48_RS15825	COG1104	cysteine desulfurase activity
CXB48_RS15850	COG3134	Outer membrane lipoprotein
CXB48_RS15865	COG1862	Preprotein translocase
CXB48_RS15885	COG1278	Cold shock
CXB48_RS15895	COG0795	lipopolysaccharide-transporting ATPase activity
CXB48_RS15900	COG0795	lipopolysaccharide-transporting ATPase activity
CXB48_RS15905	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CXB48_RS15935	COG0490	domain, Protein
CXB48_RS15935	COG0471	metal ion transport
CXB48_RS15940	COG0477	Major facilitator Superfamily
CXB48_RS15945	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
CXB48_RS15965	COG3081	Nucleoid-associated protein
CXB48_RS15970	COG2326	polyphosphate kinase activity
CXB48_RS15990	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CXB48_RS15995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CXB48_RS16035	COG0402	S-adenosylhomocysteine deaminase activity
CXB48_RS16040	COG0803	Belongs to the bacterial solute-binding protein 9 family
CXB48_RS16050	COG1121	(ABC) transporter
CXB48_RS16055	COG1802	Transcriptional regulator
CXB48_RS16060	COG2252	PERMEase
CXB48_RS16085	COG4266	Belongs to the allantoicase family
CXB48_RS16090	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
CXB48_RS16100	COG2233	PERMEase
CXB48_RS16105	COG4651	solute:proton antiporter activity
CXB48_RS16105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CXB48_RS16110	COG2233	PERMEase
CXB48_RS16125	COG0840	transmembrane signaling receptor activity
CXB48_RS16130	COG1309	transcriptional regulator
CXB48_RS16150	COG3344	reverse transcriptase
CXB48_RS16160	COG3300	MHYT domain
CXB48_RS16160	COG5001	Diguanylate cyclase
CXB48_RS16165	COG0708	Exodeoxyribonuclease III
CXB48_RS16185	COG2351	hydroxyisourate hydrolase activity
CXB48_RS16190	COG0583	DNA-binding transcription factor activity
CXB48_RS16195	COG3960	tartronate-semialdehyde synthase activity
CXB48_RS16200	COG3622	Belongs to the hyi family
CXB48_RS16205	COG2084	Dehydrogenase
CXB48_RS16215	COG0469	pyruvate kinase activity
CXB48_RS16220	COG4413	Urea transporter
CXB48_RS16230	COG1017	nitric oxide dioxygenase activity
CXB48_RS16230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXB48_RS16245	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CXB48_RS16250	COG3706	GGDEF domain
CXB48_RS16270	COG0583	DNA-binding transcription factor activity
CXB48_RS16275	COG1279	arginine transmembrane transporter activity
CXB48_RS16300	COG1704	LemA family
CXB48_RS16330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXB48_RS16335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS16345	COG0459	protein refolding
CXB48_RS16350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CXB48_RS16355	COG3030	protein affecting phage T7 exclusion by the F plasmid
CXB48_RS16365	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS16385	COG0668	transmembrane transport
CXB48_RS16390	COG1666	GTP binding
CXB48_RS16395	COG0745	RESPONSE REGULATOR receiver
CXB48_RS16410	COG2096	Adenosyltransferase
CXB48_RS16450	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CXB48_RS16455	COG0653	protein targeting
CXB48_RS16505	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CXB48_RS16510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CXB48_RS16530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CXB48_RS16535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CXB48_RS16545	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CXB48_RS16550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CXB48_RS16560	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CXB48_RS16565	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CXB48_RS16585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CXB48_RS16600	COG0582	viral genome integration into host DNA
CXB48_RS16610	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CXB48_RS16615	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CXB48_RS16625	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CXB48_RS16650	COG0559	Belongs to the binding-protein-dependent transport system permease family
CXB48_RS16685	COG4294	response to UV
CXB48_RS16690	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS16695	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CXB48_RS16700	COG1024	Enoyl-CoA hydratase
CXB48_RS16730	COG0789	Transcriptional regulator
CXB48_RS16735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CXB48_RS16745	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CXB48_RS16760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CXB48_RS16805	COG0288	reversible hydration of carbon dioxide
CXB48_RS16810	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CXB48_RS16825	COG0456	acetyltransferase
CXB48_RS16835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CXB48_RS16855	COG2851	Citrate transporter
CXB48_RS16865	COG0019	diaminopimelate decarboxylase activity
CXB48_RS16885	COG3008	intermembrane lipid transfer
CXB48_RS16890	COG2995	paraquat-inducible protein a
CXB48_RS16895	COG2995	paraquat-inducible protein a
CXB48_RS16940	COG1183	phosphatidylcholine synthase activity
CXB48_RS16945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CXB48_RS16955	COG0028	Belongs to the TPP enzyme family
CXB48_RS16975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXB48_RS16985	COG3039	Transposase
CXB48_RS17015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CXB48_RS17030	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CXB48_RS17045	COG2264	protein methyltransferase activity
CXB48_RS17065	COG0138	bifunctional purine biosynthesis protein purh
CXB48_RS17075	COG0784	Response regulator, receiver
CXB48_RS17075	COG2205	protein histidine kinase activity
CXB48_RS17075	COG5002	protein histidine kinase activity
CXB48_RS17080	COG2124	cytochrome p450
CXB48_RS17095	COG0679	Auxin Efflux Carrier
CXB48_RS17110	COG0436	Aminotransferase
CXB48_RS17115	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXB48_RS17120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CXB48_RS17130	COG4191	Histidine kinase
CXB48_RS17150	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CXB48_RS17155	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CXB48_RS17160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CXB48_RS17165	COG0166	Belongs to the GPI family
CXB48_RS17175	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CXB48_RS17200	COG1185	polyribonucleotide nucleotidyltransferase activity
CXB48_RS17205	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CXB48_RS17210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CXB48_RS17215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CXB48_RS17220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CXB48_RS17225	COG0195	Participates in both transcription termination and antitermination
CXB48_RS17225	COG2251	uridine kinase activity
CXB48_RS17230	COG0779	Required for maturation of 30S ribosomal subunits
CXB48_RS17245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CXB48_RS17250	COG0149	triose-phosphate isomerase activity
CXB48_RS17255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CXB48_RS17260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CXB48_RS17290	COG0505	Belongs to the CarA family
CXB48_RS17295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CXB48_RS17300	COG0484	heat shock protein binding
CXB48_RS17305	COG0443	Heat shock 70 kDa protein
CXB48_RS17310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CXB48_RS17315	COG0497	DNA recombination
CXB48_RS17320	COG3344	reverse transcriptase
CXB48_RS17330	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CXB48_RS17335	COG2914	Belongs to the UPF0125 (RnfH) family
CXB48_RS17345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CXB48_RS17355	COG1620	l-lactate permease
CXB48_RS17360	COG0247	lactate metabolic process
CXB48_RS17365	COG1139	Iron-sulfur cluster binding protein
CXB48_RS17480	COG2135	peptidase activity
CXB48_RS17490	COG0667	Aldo Keto reductase
CXB48_RS17520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS17540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXB48_RS17540	COG1017	nitric oxide dioxygenase activity
CXB48_RS17590	COG2132	Multicopper oxidase
CXB48_RS17610	COG2217	Heavy metal translocating P-type atpase
CXB48_RS17655	COG0469	pyruvate kinase activity
CXB48_RS17790	COG4372	Transposase
CXB48_RS17805	COG3012	SEC-C Motif Domain Protein
CXB48_RS17810	COG4372	Transposase
CXB48_RS17815	COG3436	PFAM IS66 Orf2 family protein
CXB48_RS17860	COG4372	Transposase
CXB48_RS17900	COG1280	lysine exporter protein (LysE YggA)
CXB48_RS17915	COG0366	Alpha amylase catalytic
CXB48_RS17930	COG2909	trisaccharide binding
CXB48_RS17935	COG3833	ABC-type maltose transport systems, permease component
CXB48_RS17940	COG1175	transmembrane transport
CXB48_RS17950	COG0366	Alpha amylase catalytic
CXB48_RS17970	COG4580	involved in the transport of maltose and maltodextrins
CXB48_RS17985	COG4989	oxidoreductase activity
CXB48_RS17995	COG0800	Aldolase
CXB48_RS18010	COG1737	Transcriptional regulator
CXB48_RS18030	COG2814	Major facilitator Superfamily
CXB48_RS18080	COG3154	lipid carrier protein
CXB48_RS18085	COG0826	peptidase U32
CXB48_RS18090	COG0826	peptidase U32
CXB48_RS18100	COG3604	Transcriptional regulator
CXB48_RS18130	COG3256	nitric oxide reductase
CXB48_RS18135	COG2010	Cytochrome c
CXB48_RS18160	COG3391	amine dehydrogenase activity
CXB48_RS18165	COG2010	Cytochrome c
CXB48_RS18185	COG2010	Cytochrome c
CXB48_RS18190	COG0714	Associated with various cellular activities
CXB48_RS18195	COG1845	cytochrome c oxidase, subunit III
CXB48_RS18205	COG0535	radical SAM domain protein
CXB48_RS18210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CXB48_RS18210	COG1648	precorrin-2 dehydrogenase activity
CXB48_RS18255	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CXB48_RS18255	COG0517	IMP dehydrogenase activity
CXB48_RS18255	COG0617	tRNA 3'-terminal CCA addition
CXB48_RS18260	COG3278	Belongs to the heme-copper respiratory oxidase family
CXB48_RS18265	COG0840	transmembrane signaling receptor activity
CXB48_RS18270	COG1028	Short-chain dehydrogenase reductase Sdr
CXB48_RS18290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CXB48_RS18305	COG4263	nitrous-oxide reductase activity
CXB48_RS18310	COG0348	domain, Protein
CXB48_RS18310	COG3901	Regulator of nitric oxide reductase transcription
CXB48_RS18315	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS18330	COG3189	MarR family transcriptional regulator
CXB48_RS18345	COG0492	ferredoxin-NADP+ reductase activity
CXB48_RS18350	COG1760	l-serine dehydratase
CXB48_RS18370	COG2154	pterin-4-alpha-carbinolamine dehydratase
CXB48_RS18385	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CXB48_RS18400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
CXB48_RS18405	COG0402	S-adenosylhomocysteine deaminase activity
CXB48_RS18415	COG1607	acyl-coa hydrolase
CXB48_RS18420	COG2824	Alkylphosphonate utilization operon protein PhnA
CXB48_RS18425	COG1278	Cold shock
CXB48_RS18445	COG1079	Belongs to the binding-protein-dependent transport system permease family
CXB48_RS18455	COG3845	ABC transporter
CXB48_RS18510	COG1917	Cupin 2, conserved barrel domain protein
CXB48_RS18510	COG2207	Transcriptional regulator
CXB48_RS18515	COG1309	transcriptional regulator
CXB48_RS18520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXB48_RS18525	COG1335	isochorismatase
CXB48_RS18530	COG0251	oxidation-reduction process
CXB48_RS18535	COG0596	Alpha beta hydrolase
CXB48_RS18540	COG0778	Nitroreductase
CXB48_RS18545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CXB48_RS18575	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CXB48_RS18580	COG2814	Major facilitator Superfamily
CXB48_RS18585	COG1309	transcriptional regulator
CXB48_RS18595	COG2217	Heavy metal translocating P-type atpase
CXB48_RS18605	COG0840	transmembrane signaling receptor activity
CXB48_RS18620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CXB48_RS18635	COG2169	Transcriptional regulator
CXB48_RS18635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CXB48_RS18645	COG0084	hydrolase, TatD family'
CXB48_RS18650	COG0840	transmembrane signaling receptor activity
CXB48_RS18660	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXB48_RS18665	COG1515	deoxyribonuclease V activity
CXB48_RS18675	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CXB48_RS18680	COG0180	Tryptophanyl-tRNA synthetase
CXB48_RS18685	COG2945	thiolester hydrolase activity
CXB48_RS18710	COG1252	NADH dehydrogenase
CXB48_RS18785	COG3300	MHYT domain
CXB48_RS18785	COG5001	Diguanylate cyclase
CXB48_RS18790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CXB48_RS18795	COG0305	Participates in initiation and elongation during chromosome replication
CXB48_RS18800	COG0359	binds to the 23S rRNA
CXB48_RS18810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CXB48_RS18815	COG0360	Binds together with S18 to 16S ribosomal RNA
CXB48_RS18820	COG4191	Histidine kinase
CXB48_RS18820	COG0784	Response regulator, receiver
CXB48_RS18825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CXB48_RS18845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CXB48_RS18850	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CXB48_RS18855	COG0330	HflC and HflK could
CXB48_RS18860	COG0330	HflC and HflK could
CXB48_RS18865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CXB48_RS18870	COG1923	regulation of RNA biosynthetic process
CXB48_RS18875	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CXB48_RS18880	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CXB48_RS18885	COG0860	N-Acetylmuramoyl-L-alanine amidase
CXB48_RS18890	COG0802	atpase or kinase
CXB48_RS18895	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CXB48_RS18895	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CXB48_RS18920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CXB48_RS18930	COG0531	amino acid
CXB48_RS18935	COG4303	Ethanolamine ammonia lyase large subunit
CXB48_RS18955	COG3228	Belongs to the MtfA family
CXB48_RS18980	COG3300	MHYT domain
CXB48_RS18980	COG5001	Diguanylate cyclase
CXB48_RS18990	COG0076	glutamate decarboxylase activity
CXB48_RS18995	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CXB48_RS19020	COG1722	exodeoxyribonuclease VII activity
CXB48_RS19025	COG0142	geranyltranstransferase activity
CXB48_RS19030	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CXB48_RS19050	COG4221	oxidoreductase activity
CXB48_RS19060	COG1643	Atp-dependent helicase
CXB48_RS19080	COG1522	sequence-specific DNA binding
CXB48_RS19130	COG0829	nickel cation binding
CXB48_RS19135	COG0831	urea catabolic process
CXB48_RS19145	COG0832	Belongs to the urease beta subunit family
CXB48_RS19150	COG0804	urea catabolic process
CXB48_RS19155	COG1953	Uracil, thiamine, allantoin
CXB48_RS19165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CXB48_RS19175	COG2814	Major facilitator Superfamily
CXB48_RS19180	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CXB48_RS19195	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CXB48_RS19200	COG0830	nickel cation binding
CXB48_RS19210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CXB48_RS19225	COG4993	Dehydrogenase
CXB48_RS19230	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CXB48_RS19235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CXB48_RS19250	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS19255	COG3437	response regulator, receiver
CXB48_RS19255	COG3850	Histidine kinase
CXB48_RS19255	COG4999	Histidine kinase
CXB48_RS19255	COG2205	protein histidine kinase activity
CXB48_RS19260	COG0351	phosphomethylpyrimidine kinase
CXB48_RS19260	COG0352	thiamine-phosphate diphosphorylase activity
CXB48_RS19265	COG0352	thiamine-phosphate diphosphorylase activity
CXB48_RS19270	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CXB48_RS19285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CXB48_RS19290	COG1702	phosphate starvation-inducible protein PhoH
CXB48_RS19295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CXB48_RS19300	COG4535	Mg2 and Co2 transporter CorC
CXB48_RS19305	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CXB48_RS19320	COG0495	leucyl-tRNA aminoacylation
CXB48_RS19335	COG3036	rescue of stalled ribosome
CXB48_RS19340	COG2951	lytic endotransglycosylase activity
CXB48_RS19350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CXB48_RS19355	COG0321	lipoyl(octanoyl) transferase activity
CXB48_RS19360	COG2921	Belongs to the UPF0250 family
CXB48_RS19365	COG1686	Belongs to the peptidase S11 family
CXB48_RS19375	COG2951	lytic endotransglycosylase activity
CXB48_RS19380	COG0772	Belongs to the SEDS family
CXB48_RS19385	COG0768	penicillin binding
CXB48_RS19390	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CXB48_RS19400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CXB48_RS19405	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CXB48_RS19410	COG0586	Pfam SNARE associated Golgi protein
CXB48_RS19420	COG1346	cytolysis
CXB48_RS19440	COG0702	epimerase
CXB48_RS19445	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CXB48_RS19455	COG1162	GTPase activity
CXB48_RS19460	COG1360	Flagellar Motor Protein
CXB48_RS19465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CXB48_RS19480	COG0688	phosphatidylethanolamine metabolic process
CXB48_RS19490	COG2200	EAL domain
CXB48_RS19495	COG1063	alcohol dehydrogenase
CXB48_RS19500	COG3830	Belongs to the UPF0237 family
CXB48_RS19500	COG0560	Phosphoserine phosphatase
CXB48_RS19535	COG3150	esterase
CXB48_RS19540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CXB48_RS19550	COG0494	nUDIX hydrolase
CXB48_RS19560	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CXB48_RS19565	COG1538	Outer membrane efflux protein
CXB48_RS19570	COG1519	Transferase
CXB48_RS19585	COG0667	Aldo Keto reductase
CXB48_RS19605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CXB48_RS19605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CXB48_RS19620	COG1132	(ABC) transporter
CXB48_RS19655	COG0438	transferase activity, transferring glycosyl groups
CXB48_RS19660	COG2192	nodulation
CXB48_RS19685	COG0438	transferase activity, transferring glycosyl groups
CXB48_RS19690	COG0859	PFAM glycosyl transferase family 9
CXB48_RS19695	COG0859	PFAM glycosyl transferase family 9
CXB48_RS19705	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CXB48_RS19730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CXB48_RS19735	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS19755	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS19775	COG1073	alpha beta
CXB48_RS19775	COG2226	methyltransferase
CXB48_RS19780	COG0156	8-amino-7-oxononanoate synthase activity
CXB48_RS19785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CXB48_RS19790	COG1040	competence protein
CXB48_RS19795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CXB48_RS19800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CXB48_RS19835	COG1304	FMN binding
CXB48_RS19845	COG1960	acyl-CoA dehydrogenase activity
CXB48_RS19850	COG3263	regulation of cellular component size
CXB48_RS19855	COG3264	Mechanosensitive ion channel
CXB48_RS19855	COG1196	nuclear chromosome segregation
CXB48_RS19860	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CXB48_RS19865	COG5002	protein histidine kinase activity
CXB48_RS19875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CXB48_RS19880	COG2205	protein histidine kinase activity
CXB48_RS19880	COG2198	Histidine kinase
CXB48_RS19880	COG0784	Response regulator, receiver
CXB48_RS19910	COG0330	HflC and HflK could
CXB48_RS19955	COG3344	reverse transcriptase
CXB48_RS19975	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CXB48_RS19990	COG0513	Belongs to the DEAD box helicase family
CXB48_RS19995	COG1289	transmembrane transporter activity
CXB48_RS20005	COG2081	HI0933 family
CXB48_RS20045	COG0191	fructose-bisphosphate aldolase activity
CXB48_RS20060	COG0126	phosphoglycerate kinase activity
CXB48_RS20065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CXB48_RS20070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CXB48_RS20075	COG0583	DNA-binding transcription factor activity
CXB48_RS20080	COG2175	clavaminate synthase activity
CXB48_RS20090	COG2226	methyltransferase
CXB48_RS20095	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CXB48_RS20105	COG0842	Transport permease protein
CXB48_RS20110	COG1131	(ABC) transporter
CXB48_RS20115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CXB48_RS20120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CXB48_RS20140	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CXB48_RS20145	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CXB48_RS20150	COG0513	Belongs to the DEAD box helicase family
CXB48_RS20165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CXB48_RS20170	COG2353	YceI-like domain
CXB48_RS20175	COG3038	cytochrome b561
CXB48_RS20185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CXB48_RS20195	COG2201	protein-glutamate methylesterase activity
CXB48_RS20200	COG0784	Response regulator, receiver
CXB48_RS20200	COG0643	Histidine kinase
CXB48_RS20200	COG2198	Histidine kinase
CXB48_RS20240	COG1678	Uncharacterized ACR, COG1678
CXB48_RS20255	COG0540	Belongs to the ATCase OTCase family
CXB48_RS20310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXB48_RS20315	COG2813	Specifically methylates the guanine in position
CXB48_RS20315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CXB48_RS20325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CXB48_RS20330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CXB48_RS20355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CXB48_RS20370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CXB48_RS20375	COG2022	thiamine diphosphate biosynthetic process
CXB48_RS20385	COG2363	Small membrane protein
CXB48_RS20390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CXB48_RS20410	COG2177	Part of the ABC transporter FtsEX involved in
CXB48_RS20415	COG2884	Cell division ATP-binding protein ftsE
CXB48_RS20420	COG0552	protein localization to endoplasmic reticulum
CXB48_RS20425	COG0612	Peptidase, M16
CXB48_RS20430	COG0612	Peptidase, M16
CXB48_RS20435	COG0742	ribosomal rna small subunit methyltransferase
CXB48_RS20465	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CXB48_RS20470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CXB48_RS20475	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CXB48_RS20495	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CXB48_RS20505	COG0693	protein deglycase activity
CXB48_RS20520	COG0129	dihydroxy-acid dehydratase activity
CXB48_RS20525	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CXB48_RS20550	COG0584	glycerophosphoryl diester phosphodiesterase
CXB48_RS20560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXB48_RS20575	COG0704	Plays a role in the regulation of phosphate uptake
CXB48_RS20580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CXB48_RS20585	COG0573	inorganic phosphate transmembrane transporter activity
CXB48_RS20600	COG1607	acyl-coa hydrolase
CXB48_RS20605	COG3706	GGDEF domain
CXB48_RS20605	COG2203	Gaf domain
CXB48_RS20605	COG4251	negative regulation of phosphorylation
CXB48_RS20605	COG5001	Diguanylate cyclase
CXB48_RS20620	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CXB48_RS20625	COG1074	ATP-dependent DNA helicase activity
CXB48_RS20630	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
CXB48_RS20645	COG3180	Ammonia monooxygenase
CXB48_RS20680	COG5001	Diguanylate cyclase
CXB48_RS20680	COG4251	negative regulation of phosphorylation
CXB48_RS20680	COG3706	GGDEF domain
CXB48_RS20680	COG2203	Gaf domain
CXB48_RS20685	COG0840	transmembrane signaling receptor activity
CXB48_RS20695	COG3039	Transposase
CXB48_RS20705	COG2358	TRAP transporter, solute receptor (TAXI family
CXB48_RS20715	COG0700	Nucleoside recognition
CXB48_RS20735	COG2204	response regulator
CXB48_RS20740	COG5002	protein histidine kinase activity
CXB48_RS20750	COG3023	N-Acetylmuramoyl-L-alanine amidase
CXB48_RS20775	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CXB48_RS20780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXB48_RS20780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CXB48_RS20795	COG1178	ABC-type Fe3 transport system permease component
CXB48_RS20805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXB48_RS20815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CXB48_RS20820	COG0006	proline dipeptidase activity
CXB48_RS20825	COG3079	Belongs to the UPF0149 family
CXB48_RS20845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CXB48_RS20865	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CXB48_RS20875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CXB48_RS20880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CXB48_RS20885	COG4942	peptidase
CXB48_RS20890	COG0793	Belongs to the peptidase S41A family
CXB48_RS20895	COG2861	carbohydrate metabolic process
CXB48_RS20910	COG0107	imidazoleglycerol-phosphate synthase activity
CXB48_RS20915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CXB48_RS20930	COG0131	Imidazoleglycerol-phosphate dehydratase
CXB48_RS20935	COG3707	response regulator
CXB48_RS20940	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CXB48_RS20950	COG1116	anion transmembrane transporter activity
CXB48_RS20965	COG1194	a g-specific adenine glycosylase
CXB48_RS20970	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CXB48_RS20980	COG1525	nuclease
CXB48_RS21015	COG0676	glucose-6-phosphate 1-epimerase activity
CXB48_RS21050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CXB48_RS21070	COG3052	prosthetic group binding
CXB48_RS21075	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
CXB48_RS21085	COG4221	oxidoreductase activity
CXB48_RS21090	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CXB48_RS21105	COG2358	TRAP transporter, solute receptor (TAXI family
CXB48_RS21145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CXB48_RS21155	COG3360	Dodecin
CXB48_RS21160	COG0625	glutathione transferase activity
CXB48_RS21180	COG1525	nuclease
CXB48_RS21180	COG0737	Belongs to the 5'-nucleotidase family
CXB48_RS21180	COG4085	toxin activity
CXB48_RS21200	COG1132	(ABC) transporter
CXB48_RS21225	COG2323	membrane
CXB48_RS21230	COG0583	DNA-binding transcription factor activity
CXB48_RS21260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CXB48_RS21265	COG0339	signal peptide processing
CXB48_RS21295	COG0659	secondary active sulfate transmembrane transporter activity
CXB48_RS21305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CXB48_RS21310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CXB48_RS21315	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CXB48_RS21345	COG0109	protoheme IX farnesyltransferase activity
CXB48_RS21370	COG1595	DNA-templated transcription, initiation
CXB48_RS21385	COG0523	cobalamin synthesis protein
CXB48_RS21400	COG4251	negative regulation of phosphorylation
CXB48_RS21405	COG0784	Response regulator, receiver
CXB48_RS21420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CXB48_RS21425	COG1349	DNA-binding transcription factor activity
CXB48_RS21435	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CXB48_RS21440	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CXB48_RS21445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CXB48_RS21450	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CXB48_RS21455	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CXB48_RS21460	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CXB48_RS21465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CXB48_RS21475	COG0356	it plays a direct role in the translocation of protons across the membrane
CXB48_RS21485	COG1475	DNA binding
CXB48_RS21490	COG1192	Involved in chromosome partitioning
CXB48_RS21495	COG0357	Ribosomal RNA small subunit methyltransferase G
CXB48_RS21500	COG0445	tRNA wobble uridine modification
CXB48_RS21505	COG1320	monovalent cation:proton antiporter activity
CXB48_RS21520	COG0651	ATP synthesis coupled electron transport
CXB48_RS21525	COG1006	Multisubunit Na H antiporter MnhC subunit
CXB48_RS21530	COG2111	Na H antiporter
CXB48_RS21535	COG2111	Na H antiporter
CXB48_RS21535	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CXB48_RS21540	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CXB48_RS21545	COG0706	membrane insertase activity
CXB48_RS21550	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CXB48_RS21555	COG0594	ribonuclease P activity
CXB48_RS21560	COG0230	Belongs to the bacterial ribosomal protein bL34 family