locus-tag	class	description
B1F85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B1F85_RS00010	COG0592	DNA-directed DNA polymerase activity
B1F85_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1F85_RS00020	COG0187	DNA topoisomerase II activity
B1F85_RS00025	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
B1F85_RS00030	COG0732	type I restriction modification DNA specificity domain
B1F85_RS00035	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1F85_RS00140	COG2433	Pfam Transposase IS66
B1F85_RS00145	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS00160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
B1F85_RS00215	COG0514	ATP-dependent DNA helicase (RecQ)
B1F85_RS00225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F85_RS00240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
B1F85_RS00245	COG0751	glycine-tRNA ligase activity
B1F85_RS00250	COG0752	glycyl-tRNA synthetase alpha subunit
B1F85_RS00255	COG2818	Glycosylase
B1F85_RS00280	COG0569	domain protein
B1F85_RS00285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B1F85_RS00290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1F85_RS00295	COG0242	peptide deformylase activity
B1F85_RS00305	COG0758	DNA mediated transformation
B1F85_RS00310	COG0009	L-threonylcarbamoyladenylate synthase
B1F85_RS00320	COG0408	coproporphyrinogen oxidase activity
B1F85_RS00325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1F85_RS00340	COG3119	arylsulfatase activity
B1F85_RS00345	COG0583	DNA-binding transcription factor activity
B1F85_RS00385	COG0159	tryptophan synthase activity
B1F85_RS00390	COG0133	tryptophan synthase activity
B1F85_RS00405	COG3360	Dodecin
B1F85_RS00415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F85_RS00420	COG1764	response to oxidative stress
B1F85_RS00450	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B1F85_RS00460	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
B1F85_RS00470	COG0672	)-iron permease
B1F85_RS00475	COG0583	DNA-binding transcription factor activity
B1F85_RS00480	COG1335	isochorismatase
B1F85_RS00485	COG1280	lysine exporter protein (LysE YggA)
B1F85_RS00495	COG0488	(ABC) transporter
B1F85_RS00515	COG3328	transposase activity
B1F85_RS00535	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1F85_RS00555	COG0181	hydroxymethylbilane synthase activity
B1F85_RS00565	COG2972	Histidine kinase
B1F85_RS00565	COG0745	RESPONSE REGULATOR receiver
B1F85_RS00570	COG0165	Argininosuccinate lyase
B1F85_RS00575	COG0700	Nucleoside recognition
B1F85_RS00585	COG0612	Peptidase, M16
B1F85_RS00590	COG1283	sodium-dependent phosphate transmembrane transporter activity
B1F85_RS00615	COG0583	DNA-binding transcription factor activity
B1F85_RS00620	COG0534	Mate efflux family protein
B1F85_RS00635	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1F85_RS00660	COG0427	acetyl-CoA hydrolase
B1F85_RS00680	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B1F85_RS00690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS00705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS00715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1F85_RS00720	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F85_RS00740	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS00750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B1F85_RS00755	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B1F85_RS00765	COG0747	negative chemotaxis
B1F85_RS00770	COG2003	Belongs to the UPF0758 family
B1F85_RS00775	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B1F85_RS00780	COG0756	dUTP diphosphatase activity
B1F85_RS00785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1F85_RS00790	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1F85_RS00800	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B1F85_RS00805	COG0708	Exodeoxyribonuclease III
B1F85_RS00815	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B1F85_RS00820	COG1561	YicC-like family, N-terminal region
B1F85_RS00825	COG0194	GDP metabolic process
B1F85_RS00830	COG1758	RNA polymerase activity
B1F85_RS00835	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1F85_RS00870	COG0848	biopolymer transport protein
B1F85_RS00885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B1F85_RS00905	COG2851	Citrate transporter
B1F85_RS00915	COG0606	chelatase, subunit chli
B1F85_RS00960	COG0697	spore germination
B1F85_RS00970	COG0583	DNA-binding transcription factor activity
B1F85_RS00990	COG2072	flavoprotein involved in K transport
B1F85_RS01010	COG1126	abc transporter atp-binding protein
B1F85_RS01015	COG0583	DNA-binding transcription factor activity
B1F85_RS01020	COG3549	Plasmid maintenance system killer
B1F85_RS01040	COG0347	Belongs to the P(II) protein family
B1F85_RS01045	COG0004	ammonium transporteR
B1F85_RS01055	COG0432	Pfam Uncharacterised protein family UPF0047
B1F85_RS01070	COG0546	phosphoglycolate phosphatase activity
B1F85_RS01075	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1F85_RS01085	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B1F85_RS01090	COG0019	diaminopimelate decarboxylase activity
B1F85_RS01105	COG1965	Belongs to the frataxin family
B1F85_RS01115	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F85_RS01135	COG1301	dicarboxylic acid transport
B1F85_RS01140	COG0189	ligase activity
B1F85_RS01145	COG4067	protein conserved in archaea
B1F85_RS01145	COG0189	ligase activity
B1F85_RS01150	COG2200	EAL domain
B1F85_RS01150	COG3287	FIST C domain
B1F85_RS01150	COG2199	diguanylate cyclase activity
B1F85_RS01155	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B1F85_RS01160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B1F85_RS01165	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B1F85_RS01235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS01240	COG0747	negative chemotaxis
B1F85_RS01245	COG0601	transmembrane transport
B1F85_RS01250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS01285	COG3328	transposase activity
B1F85_RS01295	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F85_RS01300	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS01310	COG1522	sequence-specific DNA binding
B1F85_RS01325	COG4172	Belongs to the ABC transporter superfamily
B1F85_RS01330	COG4239	(ABC) transporter, permease
B1F85_RS01335	COG4174	ABC transporter (Permease)
B1F85_RS01340	COG4166	transmembrane transport
B1F85_RS01380	COG1522	sequence-specific DNA binding
B1F85_RS01390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1F85_RS01400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1F85_RS01425	COG3657	addiction module killer protein
B1F85_RS01530	COG4695	Portal protein
B1F85_RS01705	COG0484	heat shock protein binding
B1F85_RS01710	COG3328	transposase activity
B1F85_RS01730	COG4215	(ABC) transporter
B1F85_RS01775	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
B1F85_RS01780	COG1194	a g-specific adenine glycosylase
B1F85_RS01795	COG2223	nitrite transmembrane transporter activity
B1F85_RS01800	COG1448	Aminotransferase
B1F85_RS01805	COG0131	Imidazoleglycerol-phosphate dehydratase
B1F85_RS01810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B1F85_RS01820	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B1F85_RS01825	COG0107	imidazoleglycerol-phosphate synthase activity
B1F85_RS01840	COG3328	transposase activity
B1F85_RS01850	COG2861	carbohydrate metabolic process
B1F85_RS01855	COG0793	Belongs to the peptidase S41A family
B1F85_RS01860	COG4942	peptidase
B1F85_RS01865	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B1F85_RS01870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F85_RS01880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
B1F85_RS01885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B1F85_RS01895	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1F85_RS01900	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
B1F85_RS01905	COG4521	taurine ABC transporter
B1F85_RS01925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1F85_RS01935	COG1522	sequence-specific DNA binding
B1F85_RS01970	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B1F85_RS01970	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B1F85_RS01975	COG2918	glutathione biosynthetic process
B1F85_RS01985	COG2183	response to ionizing radiation
B1F85_RS02020	COG2204	response regulator
B1F85_RS02025	COG5002	protein histidine kinase activity
B1F85_RS02030	COG4115	mRNA cleavage
B1F85_RS02035	COG2161	toxin-antitoxin pair type II binding
B1F85_RS02040	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1F85_RS02055	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1F85_RS02060	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B1F85_RS02080	COG1609	Transcriptional regulator
B1F85_RS02085	COG4771	TonB-dependent receptor
B1F85_RS02090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F85_RS02095	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1F85_RS02100	COG0667	Aldo Keto reductase
B1F85_RS02110	COG3852	Histidine kinase
B1F85_RS02140	COG0301	tRNA thio-modification
B1F85_RS02140	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F85_RS02145	COG1217	gtp-binding protein TYPA
B1F85_RS02150	COG1349	DNA-binding transcription factor activity
B1F85_RS02265	COG0642	Histidine kinase
B1F85_RS02275	COG1422	Protein of unknown function (DUF1090)
B1F85_RS02280	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1F85_RS02285	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B1F85_RS02295	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B1F85_RS02305	COG0126	phosphoglycerate kinase activity
B1F85_RS02345	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1F85_RS02345	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS02350	COG2181	nitrate reductase activity
B1F85_RS02350	COG0247	lactate metabolic process
B1F85_RS02355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B1F85_RS02365	COG3469	chitinase activity
B1F85_RS02400	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B1F85_RS02405	COG0358	DNA primase activity
B1F85_RS02410	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B1F85_RS02415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B1F85_RS02420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B1F85_RS02425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1F85_RS02430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B1F85_RS02435	COG0617	tRNA 3'-terminal CCA addition
B1F85_RS02440	COG2719	SpoVR family
B1F85_RS02445	COG2718	Belongs to the UPF0229 family
B1F85_RS02450	COG2766	serine protein kinase
B1F85_RS02455	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B1F85_RS02460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1F85_RS02465	COG2967	ApaG domain
B1F85_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B1F85_RS02475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B1F85_RS02480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F85_RS02485	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B1F85_RS02490	COG3178	'Phosphotransferase
B1F85_RS02495	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1F85_RS02500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1F85_RS02510	COG4585	Histidine kinase
B1F85_RS02515	COG2197	response regulator
B1F85_RS02520	COG3842	ATPase activity
B1F85_RS02530	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1F85_RS02540	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B1F85_RS02545	COG0546	phosphoglycolate phosphatase activity
B1F85_RS02635	COG4386	tail sheath protein
B1F85_RS02675	COG3299	homolog of phage Mu protein gp47
B1F85_RS02695	COG3179	chitinase
B1F85_RS02705	COG0512	Glutamine amidotransferase of anthranilate synthase
B1F85_RS02710	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1F85_RS02715	COG0134	indole-3-glycerol-phosphate synthase activity
B1F85_RS02730	COG1765	OsmC-like protein
B1F85_RS02735	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B1F85_RS02740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
B1F85_RS02745	COG0537	adenosine 5'-monophosphoramidase activity
B1F85_RS02750	COG4221	oxidoreductase activity
B1F85_RS02760	COG1981	membrane
B1F85_RS02765	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B1F85_RS02770	COG0316	Belongs to the HesB IscA family
B1F85_RS02775	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B1F85_RS02780	COG0739	heme binding
B1F85_RS02785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B1F85_RS02825	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B1F85_RS02865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B1F85_RS02870	COG0081	regulation of translation
B1F85_RS02875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B1F85_RS02880	COG0222	ribosome binding
B1F85_RS02885	COG0085	RNA polymerase activity
B1F85_RS02890	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B1F85_RS02895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B1F85_RS02900	COG0049	tRNA binding
B1F85_RS02905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B1F85_RS02910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B1F85_RS02915	COG0051	transcription antitermination factor activity, RNA binding
B1F85_RS02920	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B1F85_RS02925	COG0088	Forms part of the polypeptide exit tunnel
B1F85_RS02930	COG0089	rRNA binding
B1F85_RS02935	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B1F85_RS02940	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B1F85_RS02945	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B1F85_RS02950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B1F85_RS02955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B1F85_RS02960	COG0255	Belongs to the universal ribosomal protein uL29 family
B1F85_RS02965	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B1F85_RS02970	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B1F85_RS02975	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
B1F85_RS02980	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B1F85_RS02985	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B1F85_RS02990	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B1F85_RS02995	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B1F85_RS03000	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B1F85_RS03005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B1F85_RS03010	COG1841	ribosomal large subunit assembly
B1F85_RS03015	COG0200	Binds to the 23S rRNA
B1F85_RS03025	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B1F85_RS03030	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B1F85_RS03035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B1F85_RS03040	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B1F85_RS03045	COG0202	RNA polymerase activity
B1F85_RS03050	COG0203	ribosomal protein L17
B1F85_RS03055	COG2193	ferroxidase activity
B1F85_RS03060	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B1F85_RS03065	COG2814	Major facilitator Superfamily
B1F85_RS03070	COG0629	single-stranded DNA binding
B1F85_RS03080	COG0483	inositol monophosphate 1-phosphatase activity
B1F85_RS03085	COG0584	glycerophosphoryl diester phosphodiesterase
B1F85_RS03090	COG3842	ATPase activity
B1F85_RS03100	COG1175	transmembrane transport
B1F85_RS03105	COG1653	transport
B1F85_RS03160	COG0668	transmembrane transport
B1F85_RS03175	COG3047	cAMP biosynthetic process
B1F85_RS03210	COG3118	belongs to the thioredoxin family
B1F85_RS03225	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B1F85_RS03230	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1F85_RS03230	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B1F85_RS03245	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1F85_RS03250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B1F85_RS03255	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B1F85_RS03260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1F85_RS03270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B1F85_RS03275	COG0142	geranyltranstransferase activity
B1F85_RS03280	COG1722	exodeoxyribonuclease VII activity
B1F85_RS03295	COG0625	glutathione transferase activity
B1F85_RS03340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
B1F85_RS03345	COG3228	Belongs to the MtfA family
B1F85_RS03350	COG0586	Pfam SNARE associated Golgi protein
B1F85_RS03360	COG4302	ethanolamine ammonia-lyase activity
B1F85_RS03365	COG4303	Ethanolamine ammonia lyase large subunit
B1F85_RS03385	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1F85_RS03400	COG0702	epimerase
B1F85_RS03420	COG1346	cytolysis
B1F85_RS03440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1F85_RS03500	COG2217	Heavy metal translocating P-type atpase
B1F85_RS03505	COG2814	Major facilitator Superfamily
B1F85_RS03515	COG0583	DNA-binding transcription factor activity
B1F85_RS03525	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B1F85_RS03540	COG1120	ATPase activity
B1F85_RS03545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS03550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS03555	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B1F85_RS03560	COG0387	Pfam Sodium calcium exchanger
B1F85_RS03585	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS03600	COG4603	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS03605	COG3845	ABC transporter
B1F85_RS03615	COG1309	transcriptional regulator
B1F85_RS03620	COG2233	PERMEase
B1F85_RS03670	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
B1F85_RS03675	COG1074	ATP-dependent DNA helicase activity
B1F85_RS03680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1F85_RS03730	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F85_RS03745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1F85_RS03830	COG4644	lycopene metabolic process
B1F85_RS03855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B1F85_RS03865	COG1131	(ABC) transporter
B1F85_RS03950	COG5599	Phosphatase
B1F85_RS03985	COG1484	DNA-dependent DNA replication
B1F85_RS04050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1F85_RS04060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B1F85_RS04135	COG3416	Protein conserved in bacteria
B1F85_RS04150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1F85_RS04150	COG1199	ATP-dependent helicase activity
B1F85_RS04155	COG0513	Belongs to the DEAD box helicase family
B1F85_RS04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
B1F85_RS04175	COG1946	Acyl-CoA thioesterase
B1F85_RS04180	COG0546	phosphoglycolate phosphatase activity
B1F85_RS04190	COG2321	neutral zinc metallopeptidase
B1F85_RS04210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1F85_RS04215	COG2252	PERMEase
B1F85_RS04220	COG2080	2 iron, 2 sulfur cluster binding
B1F85_RS04225	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1F85_RS04230	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1F85_RS04240	COG1271	oxidase subunit
B1F85_RS04245	COG1294	oxidase, subunit
B1F85_RS04255	COG2813	Specifically methylates the guanine in position
B1F85_RS04260	COG2197	response regulator
B1F85_RS04270	COG1970	mechanosensitive ion channel activity
B1F85_RS04285	COG1966	Carbon starvation protein
B1F85_RS04290	COG2879	small protein
B1F85_RS04295	COG0523	cobalamin synthesis protein
B1F85_RS04300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1F85_RS04310	COG0488	(ABC) transporter
B1F85_RS04315	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F85_RS04345	COG1067	ATP-dependent peptidase activity
B1F85_RS04355	COG2862	Uncharacterized protein family, UPF0114
B1F85_RS04365	COG0545	Peptidyl-prolyl cis-trans isomerase
B1F85_RS04370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1F85_RS04380	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B1F85_RS04415	COG0019	diaminopimelate decarboxylase activity
B1F85_RS04430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B1F85_RS04435	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS04440	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS04445	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS04450	COG0601	transmembrane transport
B1F85_RS04455	COG0747	negative chemotaxis
B1F85_RS04465	COG0747	negative chemotaxis
B1F85_RS04470	COG0747	negative chemotaxis
B1F85_RS04475	COG0747	negative chemotaxis
B1F85_RS04495	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B1F85_RS04505	COG4178	(ABC) transporter
B1F85_RS04510	COG2186	Transcriptional regulator
B1F85_RS04515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1F85_RS04520	COG2271	Major facilitator Superfamily
B1F85_RS04525	COG2721	sulfolactate sulfo-lyase activity
B1F85_RS04545	COG0730	response to heat
B1F85_RS04550	COG5001	Diguanylate cyclase
B1F85_RS04565	COG2267	carboxylic ester hydrolase activity
B1F85_RS04570	COG2197	response regulator
B1F85_RS04575	COG0601	transmembrane transport
B1F85_RS04580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS04585	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS04590	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS04600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1F85_RS04615	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
B1F85_RS04675	COG4771	TonB-dependent receptor
B1F85_RS04685	COG2205	protein histidine kinase activity
B1F85_RS04690	COG0745	RESPONSE REGULATOR receiver
B1F85_RS04700	COG3639	organic phosphonate transmembrane transporter activity
B1F85_RS04705	COG3639	organic phosphonate transmembrane transporter activity
B1F85_RS04710	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B1F85_RS04715	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
B1F85_RS04725	COG0709	Synthesizes selenophosphate from selenide and ATP
B1F85_RS04730	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B1F85_RS04740	COG0142	geranyltranstransferase activity
B1F85_RS04745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B1F85_RS04750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B1F85_RS04755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B1F85_RS04760	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B1F85_RS04765	COG3045	CreA protein
B1F85_RS04770	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS04785	COG4372	Transposase
B1F85_RS04835	COG0697	spore germination
B1F85_RS04850	COG0443	Heat shock 70 kDa protein
B1F85_RS04855	COG0484	heat shock protein binding
B1F85_RS04870	COG0804	urea catabolic process
B1F85_RS04875	COG0832	Belongs to the urease beta subunit family
B1F85_RS04890	COG0831	urea catabolic process
B1F85_RS04895	COG0829	nickel cation binding
B1F85_RS04980	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
B1F85_RS04990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F85_RS05030	COG2095	MarC family integral membrane protein
B1F85_RS05040	COG0151	Belongs to the GarS family
B1F85_RS05045	COG0138	bifunctional purine biosynthesis protein purh
B1F85_RS05055	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1F85_RS05065	COG2264	protein methyltransferase activity
B1F85_RS05080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B1F85_RS05120	COG4964	Belongs to the GSP D family
B1F85_RS05140	COG4953	penicillin-binding protein 1C
B1F85_RS05155	COG2373	Large extracellular alpha-helical protein
B1F85_RS05165	COG2373	Large extracellular alpha-helical protein
B1F85_RS05170	COG2373	Large extracellular alpha-helical protein
B1F85_RS05175	COG0534	Mate efflux family protein
B1F85_RS05185	COG1166	arginine decarboxylase activity
B1F85_RS05190	COG0023	Translation Initiation Factor
B1F85_RS05235	COG0586	Pfam SNARE associated Golgi protein
B1F85_RS05240	COG2094	Belongs to the DNA glycosylase MPG family
B1F85_RS05245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B1F85_RS05250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B1F85_RS05260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B1F85_RS05265	COG0768	penicillin binding
B1F85_RS05270	COG0772	Belongs to the SEDS family
B1F85_RS05275	COG2951	lytic endotransglycosylase activity
B1F85_RS05290	COG1686	Belongs to the peptidase S11 family
B1F85_RS05295	COG2921	Belongs to the UPF0250 family
B1F85_RS05300	COG0321	lipoyl(octanoyl) transferase activity
B1F85_RS05305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B1F85_RS05315	COG2951	lytic endotransglycosylase activity
B1F85_RS05330	COG3328	transposase activity
B1F85_RS05350	COG0495	leucyl-tRNA aminoacylation
B1F85_RS05365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
B1F85_RS05370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B1F85_RS05375	COG4535	Mg2 and Co2 transporter CorC
B1F85_RS05380	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B1F85_RS05385	COG1702	phosphate starvation-inducible protein PhoH
B1F85_RS05390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1F85_RS05405	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B1F85_RS05410	COG0352	thiamine-phosphate diphosphorylase activity
B1F85_RS05425	COG2205	protein histidine kinase activity
B1F85_RS05425	COG4999	Histidine kinase
B1F85_RS05425	COG3850	Histidine kinase
B1F85_RS05425	COG3437	response regulator, receiver
B1F85_RS05430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B1F85_RS05440	COG1522	sequence-specific DNA binding
B1F85_RS05460	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
B1F85_RS05480	COG2384	SAM-dependent methyltransferase
B1F85_RS05510	COG1484	DNA-dependent DNA replication
B1F85_RS05520	COG1643	Atp-dependent helicase
B1F85_RS05525	COG1643	Atp-dependent helicase
B1F85_RS05550	COG1002	Type II restriction enzyme, methylase subunits
B1F85_RS05555	COG1002	Type II restriction enzyme, methylase subunits
B1F85_RS05560	COG1061	Type III restriction enzyme res subunit
B1F85_RS05570	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1F85_RS05585	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS05600	COG4372	Transposase
B1F85_RS05640	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS05640	COG1216	Glycosyl transferase, family 2
B1F85_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS05685	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS05690	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B1F85_RS05690	COG0662	Cupin 2, conserved barrel domain protein
B1F85_RS05705	COG0012	GTP binding
B1F85_RS05710	COG0193	aminoacyl-tRNA hydrolase activity
B1F85_RS05715	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B1F85_RS05720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B1F85_RS05730	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B1F85_RS05735	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
B1F85_RS05745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B1F85_RS05750	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B1F85_RS05760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B1F85_RS05765	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B1F85_RS05820	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B1F85_RS05830	COG0493	'glutamate synthase
B1F85_RS05835	COG4221	oxidoreductase activity
B1F85_RS05845	COG0415	Belongs to the DNA photolyase family
B1F85_RS05850	COG0789	Transcriptional regulator
B1F85_RS05895	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
B1F85_RS05900	COG1090	epimerase
B1F85_RS05905	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
B1F85_RS05920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B1F85_RS05925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B1F85_RS05940	COG0765	amino acid transport
B1F85_RS05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS05955	COG0579	oxidoreductase
B1F85_RS06005	COG2135	peptidase activity
B1F85_RS06010	COG0501	Belongs to the peptidase M48B family
B1F85_RS06015	COG2119	membrane
B1F85_RS06020	COG2813	Specifically methylates the guanine in position
B1F85_RS06025	COG1280	lysine exporter protein (LysE YggA)
B1F85_RS06030	COG0318	PFAM AMP-dependent synthetase and ligase
B1F85_RS06060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1F85_RS06065	COG0596	Alpha beta hydrolase
B1F85_RS06070	COG0251	oxidation-reduction process
B1F85_RS06075	COG1335	isochorismatase
B1F85_RS06085	COG1309	transcriptional regulator
B1F85_RS06095	COG3845	ABC transporter
B1F85_RS06105	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS06110	COG2885	chlorophyll binding
B1F85_RS06115	COG0204	Acyl-transferase
B1F85_RS06120	COG0857	belongs to the CobB CobQ family
B1F85_RS06120	COG0280	phosphate acetyltransferase
B1F85_RS06130	COG1047	Peptidyl-prolyl cis-trans
B1F85_RS06135	COG0386	Belongs to the glutathione peroxidase family
B1F85_RS06180	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
B1F85_RS06185	COG0492	ferredoxin-NADP+ reductase activity
B1F85_RS06205	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B1F85_RS06210	COG0302	gtp cyclohydrolase
B1F85_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS06260	COG1215	transferase activity, transferring glycosyl groups
B1F85_RS06270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B1F85_RS06315	COG4774	siderophore transport
B1F85_RS06325	COG4772	TonB-dependent receptor
B1F85_RS06330	COG3712	iron ion homeostasis
B1F85_RS06355	COG1917	Cupin 2, conserved barrel domain protein
B1F85_RS06355	COG2207	Transcriptional regulator
B1F85_RS06360	COG0697	spore germination
B1F85_RS06385	COG0583	DNA-binding transcription factor activity
B1F85_RS06410	COG1566	PFAM secretion protein HlyD family protein
B1F85_RS06445	COG0300	oxidoreductase activity
B1F85_RS06455	COG0662	Cupin 2, conserved barrel domain protein
B1F85_RS06455	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B1F85_RS06470	COG1696	Membrane protein involved in D-alanine export
B1F85_RS06485	COG3420	alginic acid biosynthetic process
B1F85_RS06495	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
B1F85_RS06500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS06505	COG1215	transferase activity, transferring glycosyl groups
B1F85_RS06510	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B1F85_RS06515	COG3022	response to hydroperoxide
B1F85_RS06525	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B1F85_RS06530	COG0315	cyclic pyranopterin monophosphate synthase activity
B1F85_RS06535	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B1F85_RS06545	COG0513	Belongs to the DEAD box helicase family
B1F85_RS06555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS06560	COG4597	amino acid ABC transporter
B1F85_RS06565	COG0765	amino acid transport
B1F85_RS06570	COG1126	abc transporter atp-binding protein
B1F85_RS06580	COG2807	transmembrane transport
B1F85_RS06605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B1F85_RS06610	COG3081	Nucleoid-associated protein
B1F85_RS06625	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
B1F85_RS06630	COG0525	valine-tRNA ligase activity
B1F85_RS06650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B1F85_RS06655	COG0795	lipopolysaccharide-transporting ATPase activity
B1F85_RS06660	COG0795	lipopolysaccharide-transporting ATPase activity
B1F85_RS06665	COG1278	Cold shock
B1F85_RS06670	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1F85_RS06675	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1F85_RS06675	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B1F85_RS06680	COG0509	glycine decarboxylation via glycine cleavage system
B1F85_RS06735	COG0784	Response regulator, receiver
B1F85_RS06740	COG2202	Pas domain
B1F85_RS06740	COG2205	protein histidine kinase activity
B1F85_RS06770	COG2832	Protein of unknown function (DUF454)
B1F85_RS06780	COG4771	TonB-dependent receptor
B1F85_RS06820	COG1653	transport
B1F85_RS06825	COG1175	transmembrane transport
B1F85_RS06835	COG3842	ATPase activity
B1F85_RS06845	COG0676	glucose-6-phosphate 1-epimerase activity
B1F85_RS06850	COG1737	Transcriptional regulator
B1F85_RS06865	COG0800	Aldolase
B1F85_RS06870	COG3530	Putative quorum-sensing-regulated virulence factor
B1F85_RS06880	COG2203	Gaf domain
B1F85_RS06880	COG3706	GGDEF domain
B1F85_RS06880	COG5001	Diguanylate cyclase
B1F85_RS06880	COG4251	negative regulation of phosphorylation
B1F85_RS06885	COG5002	protein histidine kinase activity
B1F85_RS06915	COG3121	Chaperone
B1F85_RS06920	COG3188	usher protein
B1F85_RS06925	COG3121	Chaperone
B1F85_RS06950	COG0784	Response regulator, receiver
B1F85_RS06950	COG0835	chemotaxis
B1F85_RS06955	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B1F85_RS06970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B1F85_RS06975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B1F85_RS06980	COG1845	cytochrome c oxidase, subunit III
B1F85_RS06990	COG0109	protoheme IX farnesyltransferase activity
B1F85_RS06995	COG1216	Glycosyl transferase, family 2
B1F85_RS07005	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS07025	COG0640	Transcriptional regulator
B1F85_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS07030	COG3321	synthase
B1F85_RS07030	COG0604	alcohol dehydrogenase
B1F85_RS07075	COG3386	PFAM SMP-30 Gluconolaconase
B1F85_RS07100	COG3920	Histidine kinase
B1F85_RS07105	COG1802	Transcriptional regulator
B1F85_RS07120	COG3845	ABC transporter
B1F85_RS07125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F85_RS07130	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS07135	COG1079	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS07155	COG2814	Major facilitator Superfamily
B1F85_RS07180	COG5645	(Lipo)protein
B1F85_RS07195	COG3781	membrane
B1F85_RS07235	COG1388	LysM domain
B1F85_RS07235	COG0741	lytic transglycosylase activity
B1F85_RS07265	COG4669	(LipO)protein
B1F85_RS07315	COG4792	protein secretion
B1F85_RS07325	COG4794	Type iii secretion
B1F85_RS07335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1F85_RS07340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1F85_RS07355	COG1157	protein secretion by the type III secretion system
B1F85_RS07420	COG0582	viral genome integration into host DNA
B1F85_RS07430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B1F85_RS07435	COG0343	queuine tRNA-ribosyltransferase activity
B1F85_RS07440	COG1862	Preprotein translocase
B1F85_RS07455	COG3134	Outer membrane lipoprotein
B1F85_RS07470	COG1045	serine acetyltransferase
B1F85_RS07485	COG1104	cysteine desulfurase activity
B1F85_RS07495	COG0316	Belongs to the HesB IscA family
B1F85_RS07500	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
B1F85_RS07505	COG0443	Heat shock 70 kDa protein
B1F85_RS07510	COG0633	Ferredoxin
B1F85_RS07520	COG0105	UTP biosynthetic process
B1F85_RS07525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B1F85_RS07540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B1F85_RS07545	COG0124	histidyl-tRNA synthetase
B1F85_RS07560	COG1160	GTP binding
B1F85_RS07565	COG0436	Aminotransferase
B1F85_RS07570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F85_RS07580	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B1F85_RS07585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1F85_RS07595	COG0739	heme binding
B1F85_RS07600	COG1570	exodeoxyribonuclease VII activity
B1F85_RS07620	COG0519	Catalyzes the synthesis of GMP from XMP
B1F85_RS07620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1F85_RS07645	COG3604	Transcriptional regulator
B1F85_RS07670	COG2132	Multicopper oxidase
B1F85_RS07675	COG0590	tRNA wobble adenosine to inosine editing
B1F85_RS07680	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
B1F85_RS07685	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B1F85_RS07685	COG0047	phosphoribosylformylglycinamidine synthase activity
B1F85_RS07705	COG0494	nUDIX hydrolase
B1F85_RS07735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B1F85_RS07740	COG0477	Major facilitator Superfamily
B1F85_RS07745	COG4536	flavin adenine dinucleotide binding
B1F85_RS07755	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B1F85_RS07760	COG0228	four-way junction DNA binding
B1F85_RS07765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B1F85_RS07770	COG0336	Belongs to the RNA methyltransferase TrmD family
B1F85_RS07775	COG0335	large ribosomal subunit rRNA binding
B1F85_RS07780	COG4974	Belongs to the 'phage' integrase family
B1F85_RS07790	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B1F85_RS07840	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS07870	COG0457	Tetratricopeptide repeat
B1F85_RS07870	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1F85_RS07875	COG0835	chemotaxis
B1F85_RS07885	COG2201	protein-glutamate methylesterase activity
B1F85_RS07890	COG5001	Diguanylate cyclase
B1F85_RS07890	COG4251	negative regulation of phosphorylation
B1F85_RS07890	COG3706	GGDEF domain
B1F85_RS07890	COG2203	Gaf domain
B1F85_RS07895	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B1F85_RS07900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B1F85_RS07920	COG1073	alpha beta
B1F85_RS07930	COG2885	chlorophyll binding
B1F85_RS07930	COG3047	cAMP biosynthetic process
B1F85_RS07940	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
B1F85_RS07950	COG0563	adenylate kinase activity
B1F85_RS07980	COG0742	ribosomal rna small subunit methyltransferase
B1F85_RS08010	COG2937	Belongs to the GPAT DAPAT family
B1F85_RS08020	COG2226	methyltransferase
B1F85_RS08025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1F85_RS08030	COG1215	transferase activity, transferring glycosyl groups
B1F85_RS08035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B1F85_RS08045	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B1F85_RS08050	COG2171	N-acyltransferase activity
B1F85_RS08055	COG1393	Belongs to the ArsC family
B1F85_RS08070	COG0436	Aminotransferase
B1F85_RS08075	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B1F85_RS08080	COG0024	Methionine aminopeptidase
B1F85_RS08085	COG0052	Belongs to the universal ribosomal protein uS2 family
B1F85_RS08090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B1F85_RS08095	COG0528	UMP kinase activity
B1F85_RS08100	COG0233	cytoplasmic translational termination
B1F85_RS08105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B1F85_RS08115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B1F85_RS08135	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F85_RS08140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1F85_RS08145	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F85_RS08150	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F85_RS08155	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B1F85_RS08160	COG0587	DNA-directed DNA polymerase activity
B1F85_RS08165	COG0825	malonyl-CoA metabolic process
B1F85_RS08170	COG0037	tRNA processing
B1F85_RS08175	COG0504	CTP synthase activity
B1F85_RS08180	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B1F85_RS08185	COG0148	phosphopyruvate hydratase activity
B1F85_RS08195	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B1F85_RS08205	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B1F85_RS08210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B1F85_RS08215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B1F85_RS08220	COG0585	pseudouridine synthase activity
B1F85_RS08225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
B1F85_RS08230	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B1F85_RS08245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B1F85_RS08250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B1F85_RS08255	COG1546	Belongs to the CinA family
B1F85_RS08260	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B1F85_RS08265	COG2137	regulation of response to DNA damage stimulus
B1F85_RS08280	COG3148	PFAM DTW domain containing protein
B1F85_RS08300	COG0583	DNA-binding transcription factor activity
B1F85_RS08315	COG4807	Protein conserved in bacteria
B1F85_RS08320	COG1187	pseudouridine synthase activity
B1F85_RS08325	COG0519	Catalyzes the synthesis of GMP from XMP
B1F85_RS08330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B1F85_RS08360	COG3158	transport of potassium into the cell
B1F85_RS08385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F85_RS08395	COG0442	prolyl-tRNA aminoacylation
B1F85_RS08415	COG2900	Belongs to the SlyX family
B1F85_RS08430	COG0783	Belongs to the Dps family
B1F85_RS08440	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B1F85_RS08445	COG0217	transcriptional regulatory protein
B1F85_RS08450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
B1F85_RS08455	COG0632	four-way junction helicase activity
B1F85_RS08460	COG2255	four-way junction helicase activity
B1F85_RS08465	COG0824	Thioesterase
B1F85_RS08485	COG0823	Involved in the tonB-independent uptake of proteins
B1F85_RS08490	COG2885	chlorophyll binding
B1F85_RS08495	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
B1F85_RS08500	COG0602	queuosine metabolic process
B1F85_RS08505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B1F85_RS08530	COG0640	Transcriptional regulator
B1F85_RS08540	COG0431	NADPH-dependent FMN reductase
B1F85_RS08550	COG2135	peptidase activity
B1F85_RS08560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F85_RS08775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1F85_RS08795	COG0582	viral genome integration into host DNA
B1F85_RS08810	COG2433	Pfam Transposase IS66
B1F85_RS08820	COG4974	Belongs to the 'phage' integrase family
B1F85_RS08910	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F85_RS08935	COG0629	single-stranded DNA binding
B1F85_RS08990	COG0305	Participates in initiation and elongation during chromosome replication
B1F85_RS09005	COG2894	cell division
B1F85_RS09045	COG2135	peptidase activity
B1F85_RS09215	COG2433	Pfam Transposase IS66
B1F85_RS09220	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS09325	COG1621	beta-fructofuranosidase activity
B1F85_RS09345	COG1653	transport
B1F85_RS09415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1F85_RS09430	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS09440	COG1879	ABC-type sugar transport system periplasmic component
B1F85_RS09475	COG2201	protein-glutamate methylesterase activity
B1F85_RS09480	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B1F85_RS09490	COG0835	chemotaxis
B1F85_RS09495	COG0840	transmembrane signaling receptor activity
B1F85_RS09500	COG2198	Histidine kinase
B1F85_RS09500	COG0643	Histidine kinase
B1F85_RS09520	COG1252	NADH dehydrogenase
B1F85_RS09555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B1F85_RS09560	COG0237	dephospho-CoA kinase activity
B1F85_RS09580	COG4969	Belongs to the N-Me-Phe pilin family
B1F85_RS09605	COG1484	DNA-dependent DNA replication
B1F85_RS09645	COG1358	cellular component organization or biogenesis
B1F85_RS09695	COG2304	oxidoreductase activity
B1F85_RS09730	COG3023	N-Acetylmuramoyl-L-alanine amidase
B1F85_RS09740	COG0084	hydrolase, TatD family'
B1F85_RS09745	COG1609	Transcriptional regulator
B1F85_RS09755	COG1105	Belongs to the carbohydrate kinase PfkB family
B1F85_RS09760	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1F85_RS09760	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
B1F85_RS09760	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B1F85_RS09785	COG0166	Belongs to the GPI family
B1F85_RS09790	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B1F85_RS09795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B1F85_RS09810	COG2204	response regulator
B1F85_RS09815	COG4191	Histidine kinase
B1F85_RS09825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F85_RS09845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B1F85_RS09850	COG0436	Aminotransferase
B1F85_RS09855	COG1489	DNA binding
B1F85_RS09865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B1F85_RS09880	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1F85_RS09900	COG0028	Belongs to the TPP enzyme family
B1F85_RS09910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B1F85_RS09915	COG1183	phosphatidylcholine synthase activity
B1F85_RS09920	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1F85_RS09925	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B1F85_RS09960	COG3012	SEC-C Motif Domain Protein
B1F85_RS09985	COG0456	acetyltransferase
B1F85_RS09995	COG0288	reversible hydration of carbon dioxide
B1F85_RS10005	COG1418	mRNA catabolic process
B1F85_RS10020	COG2824	Alkylphosphonate utilization operon protein PhnA
B1F85_RS10025	COG2814	Major facilitator Superfamily
B1F85_RS10050	COG2203	Gaf domain
B1F85_RS10050	COG3706	GGDEF domain
B1F85_RS10050	COG4251	negative regulation of phosphorylation
B1F85_RS10050	COG5001	Diguanylate cyclase
B1F85_RS10095	COG1335	isochorismatase
B1F85_RS10100	COG3540	Alkaline phosphatase
B1F85_RS10125	COG0811	peptide transport
B1F85_RS10145	COG1215	transferase activity, transferring glycosyl groups
B1F85_RS10155	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B1F85_RS10170	COG2204	response regulator
B1F85_RS10180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1F85_RS10195	COG1595	DNA-templated transcription, initiation
B1F85_RS10250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1F85_RS10275	COG0840	transmembrane signaling receptor activity
B1F85_RS10280	COG0840	transmembrane signaling receptor activity
B1F85_RS10295	COG1073	alpha beta
B1F85_RS10310	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1F85_RS10345	COG0667	Aldo Keto reductase
B1F85_RS10350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1F85_RS10365	COG0667	Aldo Keto reductase
B1F85_RS10375	COG1595	DNA-templated transcription, initiation
B1F85_RS10385	COG4774	siderophore transport
B1F85_RS10390	COG4774	siderophore transport
B1F85_RS10485	COG0582	viral genome integration into host DNA
B1F85_RS10515	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
B1F85_RS10550	COG0463	Glycosyl transferase, family 2
B1F85_RS10555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B1F85_RS10585	COG1091	dTDP-4-dehydrorhamnose reductase activity
B1F85_RS10590	COG1088	dTDP-glucose 4,6-dehydratase activity
B1F85_RS10595	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS10610	COG2433	Pfam Transposase IS66
B1F85_RS10635	COG1280	lysine exporter protein (LysE YggA)
B1F85_RS10670	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B1F85_RS10675	COG0733	neurotransmitter:sodium symporter activity
B1F85_RS10685	COG2914	Belongs to the UPF0125 (RnfH) family
B1F85_RS10700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B1F85_RS10710	COG0497	DNA recombination
B1F85_RS10715	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B1F85_RS10720	COG0443	Heat shock 70 kDa protein
B1F85_RS10725	COG0484	heat shock protein binding
B1F85_RS10735	COG0505	Belongs to the CarA family
B1F85_RS10740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B1F85_RS10745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F85_RS10755	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B1F85_RS10765	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B1F85_RS10770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B1F85_RS10775	COG0149	triose-phosphate isomerase activity
B1F85_RS10780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B1F85_RS10795	COG0779	Required for maturation of 30S ribosomal subunits
B1F85_RS10800	COG0195	Participates in both transcription termination and antitermination
B1F85_RS10805	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B1F85_RS10810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B1F85_RS10815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B1F85_RS10820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B1F85_RS10830	COG1185	polyribonucleotide nucleotidyltransferase activity
B1F85_RS10835	COG2823	Periplasmic or secreted lipoprotein
B1F85_RS10850	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F85_RS10865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1F85_RS10875	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B1F85_RS10890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1F85_RS10895	COG0154	amidase activity
B1F85_RS10900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B1F85_RS10905	COG1077	Cell shape determining protein MreB Mrl
B1F85_RS10910	COG1792	Involved in formation and maintenance of cell shape
B1F85_RS10920	COG0424	maF-like protein
B1F85_RS10925	COG1530	ribonuclease E activity
B1F85_RS10935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F85_RS10940	COG0312	modulator of DNA gyrase
B1F85_RS10945	COG3028	Belongs to the UPF0307 family
B1F85_RS10950	COG0312	modulator of DNA gyrase
B1F85_RS10985	COG1660	Displays ATPase and GTPase activities
B1F85_RS10995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B1F85_RS11000	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B1F85_RS11005	COG1137	ATPase activity
B1F85_RS11010	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
B1F85_RS11020	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
B1F85_RS11030	COG1127	ABC transporter
B1F85_RS11035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
B1F85_RS11040	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
B1F85_RS11060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B1F85_RS11070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B1F85_RS11075	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B1F85_RS11080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B1F85_RS11090	COG3011	Protein conserved in bacteria
B1F85_RS11095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1F85_RS11105	COG0175	sulfate reduction
B1F85_RS11130	COG0180	Tryptophanyl-tRNA synthetase
B1F85_RS11135	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1F85_RS11145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B1F85_RS11150	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B1F85_RS11155	COG0625	glutathione transferase activity
B1F85_RS11160	COG2969	positive regulation of protein catabolic process
B1F85_RS11165	COG2823	Periplasmic or secreted lipoprotein
B1F85_RS11170	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
B1F85_RS11175	COG0792	nuclease activity
B1F85_RS11180	COG3107	peptidoglycan biosynthetic process
B1F85_RS11195	COG2001	Belongs to the MraZ family
B1F85_RS11200	COG0275	rRNA processing
B1F85_RS11215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1F85_RS11220	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B1F85_RS11225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1F85_RS11230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B1F85_RS11235	COG0772	Belongs to the SEDS family
B1F85_RS11240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B1F85_RS11245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B1F85_RS11250	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1F85_RS11265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B1F85_RS11270	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B1F85_RS11285	COG0653	protein targeting
B1F85_RS11290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B1F85_RS11300	COG0494	nUDIX hydrolase
B1F85_RS11310	COG1484	DNA-dependent DNA replication
B1F85_RS11330	COG2096	Adenosyltransferase
B1F85_RS11335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS11335	COG4191	Histidine kinase
B1F85_RS11345	COG1666	GTP binding
B1F85_RS11350	COG0668	transmembrane transport
B1F85_RS11360	COG2211	Major facilitator Superfamily
B1F85_RS11365	COG3695	enzyme binding
B1F85_RS11375	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS11380	COG3030	protein affecting phage T7 exclusion by the F plasmid
B1F85_RS11385	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B1F85_RS11390	COG0459	protein refolding
B1F85_RS11395	COG3385	transposase activity
B1F85_RS11425	COG0642	Histidine kinase
B1F85_RS11435	COG3642	lipopolysaccharide core region biosynthetic process
B1F85_RS11505	COG0583	DNA-binding transcription factor activity
B1F85_RS11520	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS11525	COG2814	Major facilitator Superfamily
B1F85_RS11565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F85_RS11630	COG0469	pyruvate kinase activity
B1F85_RS11650	COG0714	Associated with various cellular activities
B1F85_RS11690	COG2925	Exonuclease
B1F85_RS11700	COG0788	formyltetrahydrofolate deformylase activity
B1F85_RS11710	COG0306	phosphate transporter
B1F85_RS11720	COG1414	Transcriptional regulator
B1F85_RS11725	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B1F85_RS11730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B1F85_RS11735	COG0183	Belongs to the thiolase family
B1F85_RS11740	COG0477	Major facilitator Superfamily
B1F85_RS11750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F85_RS11755	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS11805	COG0443	Heat shock 70 kDa protein
B1F85_RS11810	COG4191	Histidine kinase
B1F85_RS11810	COG0784	Response regulator, receiver
B1F85_RS11815	COG2204	response regulator
B1F85_RS11820	COG4191	Histidine kinase
B1F85_RS11855	COG1454	alcohol dehydrogenase
B1F85_RS11885	COG1238	metal cluster binding
B1F85_RS11915	COG2267	carboxylic ester hydrolase activity
B1F85_RS11945	COG0511	ligase activity, forming carbon-carbon bonds
B1F85_RS11955	COG0439	Biotin carboxylase
B1F85_RS11960	COG3665	Urea carboxylase-associated protein
B1F85_RS11970	COG3842	ATPase activity
B1F85_RS11995	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B1F85_RS12025	COG0642	Histidine kinase
B1F85_RS12035	COG0354	folic acid binding
B1F85_RS12040	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B1F85_RS12070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B1F85_RS12075	COG0481	GTPase activity
B1F85_RS12080	COG0681	Belongs to the peptidase S26 family
B1F85_RS12090	COG0571	ribonuclease III activity
B1F85_RS12095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B1F85_RS12100	COG1381	Involved in DNA repair and RecF pathway recombination
B1F85_RS12105	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
B1F85_RS12110	COG0500	methyltransferase
B1F85_RS12115	COG2226	methyltransferase
B1F85_RS12125	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1F85_RS12165	COG2188	Transcriptional regulator
B1F85_RS12185	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS12190	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS12200	COG0523	cobalamin synthesis protein
B1F85_RS12240	COG4628	conserved protein (DUF2132)
B1F85_RS12250	COG2375	cellular response to nickel ion
B1F85_RS12255	COG1695	Transcriptional regulator
B1F85_RS12325	COG0254	rRNA binding
B1F85_RS12330	COG1181	Belongs to the D-alanine--D-alanine ligase family
B1F85_RS12340	COG0583	DNA-binding transcription factor activity
B1F85_RS12345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B1F85_RS12350	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1F85_RS12395	COG1126	abc transporter atp-binding protein
B1F85_RS12400	COG0765	amino acid transport
B1F85_RS12405	COG0765	amino acid transport
B1F85_RS12425	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1F85_RS12435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B1F85_RS12445	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B1F85_RS12460	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B1F85_RS12475	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1F85_RS12480	COG0418	dihydroorotase activity
B1F85_RS12490	COG0137	argininosuccinate synthase activity
B1F85_RS12515	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B1F85_RS12520	COG2878	Part of a membrane complex involved in electron transport
B1F85_RS12525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1F85_RS12525	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B1F85_RS12530	COG0489	protein tyrosine kinase activity
B1F85_RS12535	COG1278	Cold shock
B1F85_RS12540	COG0717	Belongs to the dCTP deaminase family
B1F85_RS12555	COG1201	RNA secondary structure unwinding
B1F85_RS12590	COG1793	dna ligase
B1F85_RS12595	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1F85_RS12595	COG1793	dna ligase
B1F85_RS12605	COG2366	antibiotic biosynthetic process
B1F85_RS12610	COG0653	protein targeting
B1F85_RS12650	COG3012	SEC-C Motif Domain Protein
B1F85_RS12685	COG1199	ATP-dependent helicase activity
B1F85_RS12690	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B1F85_RS12700	COG0259	pyridoxamine-phosphate oxidase activity
B1F85_RS12720	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
B1F85_RS12775	COG2271	Major facilitator Superfamily
B1F85_RS12805	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F85_RS12820	COG3866	Pectate lyase
B1F85_RS12825	COG2030	dehydratase
B1F85_RS12835	COG0318	PFAM AMP-dependent synthetase and ligase
B1F85_RS12845	COG2026	Addiction module toxin, RelE StbE family
B1F85_RS12855	COG1643	Atp-dependent helicase
B1F85_RS12880	COG1132	(ABC) transporter
B1F85_RS12890	COG2267	carboxylic ester hydrolase activity
B1F85_RS12920	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS12985	COG0745	RESPONSE REGULATOR receiver
B1F85_RS13000	COG0513	Belongs to the DEAD box helicase family
B1F85_RS13040	COG2996	Protein conserved in bacteria
B1F85_RS13085	COG3237	CsbD-like
B1F85_RS13090	COG1295	ribonuclease BN
B1F85_RS13095	COG0242	peptide deformylase activity
B1F85_RS13115	COG0590	tRNA wobble adenosine to inosine editing
B1F85_RS13120	COG0596	Alpha beta hydrolase
B1F85_RS13125	COG2205	protein histidine kinase activity
B1F85_RS13140	COG2133	pyrroloquinoline quinone binding
B1F85_RS13165	COG0477	Major facilitator Superfamily
B1F85_RS13170	COG2197	response regulator
B1F85_RS13195	COG3706	GGDEF domain
B1F85_RS13205	COG0583	DNA-binding transcription factor activity
B1F85_RS13215	COG2853	Lipoprotein
B1F85_RS13235	COG3162	membrane
B1F85_RS13240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1F85_RS13265	COG1742	UPF0060 membrane protein
B1F85_RS13270	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F85_RS13275	COG3089	Belongs to the UPF0270 family
B1F85_RS13280	COG1363	Peptidase, m42
B1F85_RS13285	COG0189	ligase activity
B1F85_RS13285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B1F85_RS13290	COG0367	asparagine synthase
B1F85_RS13310	COG4181	ATPase activity
B1F85_RS13315	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B1F85_RS13315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS13320	COG2326	polyphosphate kinase activity
B1F85_RS13325	COG2832	Protein of unknown function (DUF454)
B1F85_RS13335	COG0514	ATP-dependent DNA helicase (RecQ)
B1F85_RS13355	COG0840	transmembrane signaling receptor activity
B1F85_RS13470	COG1484	DNA-dependent DNA replication
B1F85_RS13535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F85_RS13540	COG0477	Major facilitator Superfamily
B1F85_RS13560	COG0385	Bile acid
B1F85_RS13565	COG2974	May be involved in recombination
B1F85_RS13595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1F85_RS13635	COG2200	EAL domain
B1F85_RS13685	COG1362	aminopeptidase activity
B1F85_RS13690	COG0564	pseudouridine synthase activity
B1F85_RS13695	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
B1F85_RS13700	COG2894	cell division
B1F85_RS13705	COG0850	regulation of cytokinetic process
B1F85_RS13710	COG1560	Kdo2-lipid A biosynthetic process
B1F85_RS13730	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS13735	COG0625	glutathione transferase activity
B1F85_RS13740	COG1131	(ABC) transporter
B1F85_RS13745	COG0842	Transport permease protein
B1F85_RS13785	COG3328	transposase activity
B1F85_RS13810	COG0811	peptide transport
B1F85_RS13815	COG0848	biopolymer transport protein
B1F85_RS13820	COG1663	tetraacyldisaccharide 4'-kinase activity
B1F85_RS13825	COG2835	tetraacyldisaccharide 4'-kinase activity
B1F85_RS13830	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B1F85_RS13835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B1F85_RS13840	COG1530	ribonuclease E activity
B1F85_RS13855	COG0546	phosphoglycolate phosphatase activity
B1F85_RS13860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1F85_RS13860	COG0616	signal peptide processing
B1F85_RS13865	COG0424	maF-like protein
B1F85_RS13875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B1F85_RS13880	COG0416	fatty acid biosynthetic process
B1F85_RS13895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1F85_RS13900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1F85_RS13910	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B1F85_RS13915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B1F85_RS13930	COG0084	hydrolase, TatD family'
B1F85_RS13970	COG0135	phosphoribosylanthranilate isomerase activity
B1F85_RS13975	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B1F85_RS13980	COG0285	dihydrofolate synthase activity
B1F85_RS13990	COG1286	toxin biosynthetic process
B1F85_RS14035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1F85_RS14055	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS14055	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1F85_RS14090	COG0277	FAD linked oxidase domain protein
B1F85_RS14095	COG0277	FAD linked oxidase domain protein
B1F85_RS14115	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
B1F85_RS14120	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1F85_RS14170	COG0583	DNA-binding transcription factor activity
B1F85_RS14175	COG0728	peptidoglycan biosynthetic process
B1F85_RS14220	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
B1F85_RS14220	COG0662	Cupin 2, conserved barrel domain protein
B1F85_RS14225	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1F85_RS14235	COG1597	lipid kinase activity
B1F85_RS14240	COG2197	response regulator
B1F85_RS14255	COG0633	Ferredoxin
B1F85_RS14255	COG3217	Mosc domain protein beta barrel domain protein
B1F85_RS14260	COG0741	lytic transglycosylase activity
B1F85_RS14265	COG0488	(ABC) transporter
B1F85_RS14270	COG0589	response to stress
B1F85_RS14320	COG1024	Enoyl-CoA hydratase
B1F85_RS14320	COG1250	3-hydroxyacyl-CoA dehydrogenase
B1F85_RS14325	COG0183	Belongs to the thiolase family
B1F85_RS14355	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B1F85_RS14375	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B1F85_RS14385	COG3568	Endonuclease Exonuclease Phosphatase
B1F85_RS14390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F85_RS14395	COG0392	lysyltransferase activity
B1F85_RS14405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1F85_RS14415	COG3718	enzyme involved in inositol metabolism
B1F85_RS14430	COG3962	Belongs to the TPP enzyme family
B1F85_RS14435	COG0673	inositol 2-dehydrogenase activity
B1F85_RS14445	COG0673	inositol 2-dehydrogenase activity
B1F85_RS14470	COG2223	nitrite transmembrane transporter activity
B1F85_RS14475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B1F85_RS14500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B1F85_RS14505	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B1F85_RS14510	COG0705	Rhomboid family
B1F85_RS14515	COG3139	Protein of unknown function (DUF1315)
B1F85_RS14525	COG0308	aminopeptidase N
B1F85_RS14555	COG3766	membrane
B1F85_RS14565	COG0754	glutathionylspermidine amidase activity
B1F85_RS14615	COG2433	Pfam Transposase IS66
B1F85_RS14620	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS14635	COG1609	Transcriptional regulator
B1F85_RS14660	COG2706	6-phosphogluconolactonase activity
B1F85_RS14675	COG0420	3'-5' exonuclease activity
B1F85_RS14690	COG2304	oxidoreductase activity
B1F85_RS14705	COG0714	Associated with various cellular activities
B1F85_RS14725	COG1971	Probably functions as a manganese efflux pump
B1F85_RS14745	COG1846	Transcriptional regulator
B1F85_RS14750	COG1566	PFAM secretion protein HlyD family protein
B1F85_RS14755	COG2814	Major facilitator Superfamily
B1F85_RS14785	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B1F85_RS14795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F85_RS14800	COG0215	cysteine-tRNA ligase activity
B1F85_RS14805	COG3284	Transcriptional regulator
B1F85_RS14810	COG3842	ATPase activity
B1F85_RS14815	COG3842	ATPase activity
B1F85_RS14825	COG0395	ABC-type sugar transport system, permease component
B1F85_RS14840	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1F85_RS14880	COG0544	peptidyl-prolyl cis-trans isomerase activity
B1F85_RS14885	COG0740	serine-type endopeptidase activity
B1F85_RS14890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B1F85_RS14895	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B1F85_RS14900	COG0776	regulation of translation
B1F85_RS14905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F85_RS14915	COG4172	Belongs to the ABC transporter superfamily
B1F85_RS14920	COG4239	(ABC) transporter, permease
B1F85_RS14925	COG4174	ABC transporter (Permease)
B1F85_RS14930	COG4166	transmembrane transport
B1F85_RS14935	COG4166	transmembrane transport
B1F85_RS14940	COG0741	lytic transglycosylase activity
B1F85_RS14940	COG1388	LysM domain
B1F85_RS14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B1F85_RS14955	COG0328	RNA-DNA hybrid ribonuclease activity
B1F85_RS14960	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1F85_RS14975	COG0431	NADPH-dependent FMN reductase
B1F85_RS14995	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS15000	COG1024	Enoyl-CoA hydratase
B1F85_RS15020	COG0306	phosphate transporter
B1F85_RS15030	COG0656	L-ascorbic acid biosynthetic process
B1F85_RS15035	COG0840	transmembrane signaling receptor activity
B1F85_RS15055	COG1472	Belongs to the glycosyl hydrolase 3 family
B1F85_RS15085	COG3046	protein related to deoxyribodipyrimidine photolyase
B1F85_RS15120	COG1408	metallophosphoesterase
B1F85_RS15135	COG0840	transmembrane signaling receptor activity
B1F85_RS15145	COG0583	DNA-binding transcription factor activity
B1F85_RS15160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B1F85_RS15165	COG1522	sequence-specific DNA binding
B1F85_RS15170	COG2354	Protein conserved in bacteria
B1F85_RS15205	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B1F85_RS15210	COG4266	Belongs to the allantoicase family
B1F85_RS15240	COG0402	S-adenosylhomocysteine deaminase activity
B1F85_RS15265	COG1196	nuclear chromosome segregation
B1F85_RS15270	COG3115	cell septum assembly
B1F85_RS15275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B1F85_RS15285	COG0456	acetyltransferase
B1F85_RS15285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B1F85_RS15300	COG0668	transmembrane transport
B1F85_RS15315	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B1F85_RS15320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B1F85_RS15350	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B1F85_RS15395	COG0189	ligase activity
B1F85_RS15395	COG4067	protein conserved in archaea
B1F85_RS15400	COG1802	Transcriptional regulator
B1F85_RS15410	COG0372	Belongs to the citrate synthase family
B1F85_RS15425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B1F85_RS15445	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F85_RS15460	COG0668	transmembrane transport
B1F85_RS15475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1F85_RS15480	COG0243	molybdopterin cofactor binding
B1F85_RS15485	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F85_RS15490	COG2815	serine threonine protein kinase
B1F85_RS15490	COG0515	serine threonine protein kinase
B1F85_RS15495	COG2223	nitrite transmembrane transporter activity
B1F85_RS15515	COG3707	response regulator
B1F85_RS15520	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1F85_RS15520	COG1116	anion transmembrane transporter activity
B1F85_RS15530	COG0167	dihydroorotate dehydrogenase activity
B1F85_RS15535	COG3130	regulation of translation
B1F85_RS15540	COG0116	Belongs to the methyltransferase superfamily
B1F85_RS15540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F85_RS15555	COG3171	Protein conserved in bacteria
B1F85_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS15560	COG2205	protein histidine kinase activity
B1F85_RS15600	COG0326	Molecular chaperone. Has ATPase activity
B1F85_RS15615	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B1F85_RS15625	COG2205	protein histidine kinase activity
B1F85_RS15625	COG5002	protein histidine kinase activity
B1F85_RS15625	COG0784	Response regulator, receiver
B1F85_RS15630	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B1F85_RS15640	COG2062	phosphohistidine phosphatase, SixA
B1F85_RS15665	COG0628	permease
B1F85_RS15685	COG2205	protein histidine kinase activity
B1F85_RS15720	COG3188	usher protein
B1F85_RS15725	COG3121	Chaperone
B1F85_RS15785	COG1484	DNA-dependent DNA replication
B1F85_RS15805	COG3328	transposase activity
B1F85_RS15820	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B1F85_RS15830	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
B1F85_RS15835	COG2205	protein histidine kinase activity
B1F85_RS15840	COG0745	RESPONSE REGULATOR receiver
B1F85_RS15860	COG0714	Associated with various cellular activities
B1F85_RS15905	COG2259	Doxx family
B1F85_RS15920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B1F85_RS15940	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
B1F85_RS15945	COG4181	ATPase activity
B1F85_RS15960	COG1376	ErfK ybiS ycfS ynhG family protein
B1F85_RS16000	COG0251	oxidation-reduction process
B1F85_RS16015	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B1F85_RS16020	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1F85_RS16030	COG4133	protoheme IX ABC transporter activity
B1F85_RS16050	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B1F85_RS16055	COG1138	Cytochrome C-type biogenesis protein
B1F85_RS16085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1F85_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS16110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1F85_RS16205	COG2197	response regulator
B1F85_RS16210	COG2205	protein histidine kinase activity
B1F85_RS16210	COG2198	Histidine kinase
B1F85_RS16210	COG0784	Response regulator, receiver
B1F85_RS16235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1F85_RS16245	COG0583	DNA-binding transcription factor activity
B1F85_RS16250	COG3485	protocatechuate 3,4-dioxygenase
B1F85_RS16255	COG3485	protocatechuate 3,4-dioxygenase
B1F85_RS16270	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B1F85_RS16285	COG2271	Major facilitator Superfamily
B1F85_RS16290	COG3185	4-Hydroxyphenylpyruvate dioxygenase
B1F85_RS16290	COG1082	Xylose isomerase domain protein TIM barrel
B1F85_RS16295	COG1309	transcriptional regulator
B1F85_RS16300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1F85_RS16305	COG0564	pseudouridine synthase activity
B1F85_RS16315	COG0746	molybdenum cofactor guanylyltransferase activity
B1F85_RS16320	COG0521	Mo-molybdopterin cofactor biosynthetic process
B1F85_RS16370	COG0024	Methionine aminopeptidase
B1F85_RS16400	COG1129	ABC transporter
B1F85_RS16405	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS16410	COG1609	Transcriptional regulator
B1F85_RS16415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1F85_RS16420	COG1869	D-ribose catabolic process
B1F85_RS16450	COG1278	Cold shock
B1F85_RS16460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B1F85_RS16465	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B1F85_RS16470	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B1F85_RS16475	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B1F85_RS16480	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B1F85_RS16485	COG0072	phenylalanine-tRNA ligase activity
B1F85_RS16490	COG0776	regulation of translation
B1F85_RS16530	COG1484	DNA-dependent DNA replication
B1F85_RS16560	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
B1F85_RS16570	COG3639	organic phosphonate transmembrane transporter activity
B1F85_RS16575	COG2188	Transcriptional regulator
B1F85_RS16580	COG3624	Phosphonate C-P lyase system protein PhnG
B1F85_RS16590	COG3626	phosphonate metabolism
B1F85_RS16595	COG3627	carbon phosphorus lyase activity
B1F85_RS16600	COG4107	phosphonate C-P lyase system protein PhnK
B1F85_RS16605	COG4778	phosphonate C-P lyase system protein PhnL
B1F85_RS16610	COG3454	Phosphonate metabolism
B1F85_RS16615	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B1F85_RS16620	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1F85_RS16660	COG0840	transmembrane signaling receptor activity
B1F85_RS16675	COG0251	oxidation-reduction process
B1F85_RS16680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1F85_RS16750	COG1968	undecaprenyl-diphosphatase activity
B1F85_RS16765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1F85_RS16770	COG0583	DNA-binding transcription factor activity
B1F85_RS16775	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B1F85_RS16825	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1F85_RS16830	COG0297	glycogen (starch) synthase activity
B1F85_RS16845	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B1F85_RS16850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B1F85_RS16855	COG0561	phosphatase activity
B1F85_RS16860	COG3387	PFAM Glycoside hydrolase 15-related
B1F85_RS16905	COG4191	Histidine kinase
B1F85_RS16905	COG0784	Response regulator, receiver
B1F85_RS16925	COG3634	alkyl hydroperoxide reductase activity
B1F85_RS16965	COG1126	abc transporter atp-binding protein
B1F85_RS16970	COG0765	amino acid transport
B1F85_RS16975	COG0765	amino acid transport
B1F85_RS17075	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS17080	COG1129	ABC transporter
B1F85_RS17085	COG1879	ABC-type sugar transport system periplasmic component
B1F85_RS17090	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS17095	COG3959	Transketolase, thiamine diphosphate binding domain
B1F85_RS17100	COG3958	Transketolase
B1F85_RS17105	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B1F85_RS17110	COG0640	Transcriptional regulator
B1F85_RS17115	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS17120	COG0829	nickel cation binding
B1F85_RS17125	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1F85_RS17130	COG0804	urea catabolic process
B1F85_RS17135	COG0832	Belongs to the urease beta subunit family
B1F85_RS17135	COG0831	urea catabolic process
B1F85_RS17140	COG0830	nickel cation binding
B1F85_RS17145	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B1F85_RS17215	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B1F85_RS17235	COG1309	transcriptional regulator
B1F85_RS17240	COG0604	alcohol dehydrogenase
B1F85_RS17250	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B1F85_RS17275	COG3486	L-lysine 6-monooxygenase (NADPH) activity
B1F85_RS17290	COG1280	lysine exporter protein (LysE YggA)
B1F85_RS17305	COG4977	sequence-specific DNA binding
B1F85_RS17370	COG2814	Major facilitator Superfamily
B1F85_RS17385	COG1024	Enoyl-CoA hydratase
B1F85_RS17390	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS17400	COG0183	Belongs to the thiolase family
B1F85_RS17410	COG0251	oxidation-reduction process
B1F85_RS17420	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B1F85_RS17435	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1F85_RS17445	COG1984	allophanate hydrolase subunit 2
B1F85_RS17520	COG0436	Aminotransferase
B1F85_RS17535	COG0511	ligase activity, forming carbon-carbon bonds
B1F85_RS17545	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B1F85_RS17550	COG1984	allophanate hydrolase subunit 2
B1F85_RS17560	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1F85_RS17565	COG4221	oxidoreductase activity
B1F85_RS17575	COG0765	amino acid transport
B1F85_RS17585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS17590	COG4948	Mandelate Racemase Muconate Lactonizing
B1F85_RS17600	COG0583	DNA-binding transcription factor activity
B1F85_RS17610	COG1957	nucleoside hydrolase
B1F85_RS17615	COG5001	Diguanylate cyclase
B1F85_RS17645	COG1396	sequence-specific DNA binding
B1F85_RS17645	COG1917	Cupin 2, conserved barrel domain protein
B1F85_RS17655	COG0784	Response regulator, receiver
B1F85_RS17655	COG4191	Histidine kinase
B1F85_RS17685	COG4774	siderophore transport
B1F85_RS17690	COG3712	iron ion homeostasis
B1F85_RS17695	COG1595	DNA-templated transcription, initiation
B1F85_RS17710	COG0642	Histidine kinase
B1F85_RS17725	COG0642	Histidine kinase
B1F85_RS17745	COG1368	sulfuric ester hydrolase activity
B1F85_RS17760	COG2076	Multidrug Resistance protein
B1F85_RS17765	COG2076	Multidrug Resistance protein
B1F85_RS17770	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B1F85_RS17775	COG0726	polysaccharide deacetylase
B1F85_RS17780	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B1F85_RS17780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1F85_RS17785	COG0463	Glycosyl transferase, family 2
B1F85_RS17790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B1F85_RS17800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B1F85_RS17865	COG2433	Pfam Transposase IS66
B1F85_RS17880	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS17915	COG0210	DNA helicase
B1F85_RS17925	COG2801	Transposase and inactivated derivatives
B1F85_RS17935	COG1484	DNA-dependent DNA replication
B1F85_RS17940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F85_RS18060	COG1396	sequence-specific DNA binding
B1F85_RS18075	COG1196	nuclear chromosome segregation
B1F85_RS18085	COG1484	DNA-dependent DNA replication
B1F85_RS18190	COG0747	negative chemotaxis
B1F85_RS18195	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS18200	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS18210	COG0601	transmembrane transport
B1F85_RS18215	COG2072	flavoprotein involved in K transport
B1F85_RS18225	COG3706	GGDEF domain
B1F85_RS18235	COG0247	lactate metabolic process
B1F85_RS18235	COG0277	FAD linked oxidase domain protein
B1F85_RS18240	COG0583	DNA-binding transcription factor activity
B1F85_RS18245	COG0583	DNA-binding transcription factor activity
B1F85_RS18255	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B1F85_RS18275	COG0598	Magnesium transport protein CorA
B1F85_RS18285	COG0587	DNA-directed DNA polymerase activity
B1F85_RS18320	COG0667	Aldo Keto reductase
B1F85_RS18335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1F85_RS18340	COG1116	anion transmembrane transporter activity
B1F85_RS18355	COG0210	DNA helicase
B1F85_RS18360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B1F85_RS18380	COG1126	abc transporter atp-binding protein
B1F85_RS18385	COG0765	amino acid transport
B1F85_RS18390	COG0765	amino acid transport
B1F85_RS18440	COG0488	(ABC) transporter
B1F85_RS18450	COG2706	6-phosphogluconolactonase activity
B1F85_RS18465	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B1F85_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS18500	COG1538	Outer membrane efflux protein
B1F85_RS18505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F85_RS18525	COG0583	DNA-binding transcription factor activity
B1F85_RS18535	COG0729	surface antigen
B1F85_RS18545	COG0708	Exodeoxyribonuclease III
B1F85_RS18550	COG2885	chlorophyll binding
B1F85_RS18555	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS18565	COG0789	Transcriptional regulator
B1F85_RS18580	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS18585	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B1F85_RS18590	COG1024	Enoyl-CoA hydratase
B1F85_RS18605	COG0316	Belongs to the HesB IscA family
B1F85_RS18605	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B1F85_RS18610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1F85_RS18625	COG1879	ABC-type sugar transport system periplasmic component
B1F85_RS18660	COG0616	signal peptide processing
B1F85_RS18680	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS18695	COG2816	NAD+ diphosphatase activity
B1F85_RS18700	COG1024	Enoyl-CoA hydratase
B1F85_RS18705	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
B1F85_RS18720	COG5002	protein histidine kinase activity
B1F85_RS18720	COG2205	protein histidine kinase activity
B1F85_RS18720	COG0784	Response regulator, receiver
B1F85_RS18730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1F85_RS18740	COG0745	RESPONSE REGULATOR receiver
B1F85_RS18760	COG1653	transport
B1F85_RS18765	COG1175	transmembrane transport
B1F85_RS18780	COG0246	Mannitol dehydrogenase
B1F85_RS18785	COG1070	Carbohydrate kinase
B1F85_RS18825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1F85_RS18825	COG1199	ATP-dependent helicase activity
B1F85_RS18840	COG3321	synthase
B1F85_RS18840	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS18840	COG0604	alcohol dehydrogenase
B1F85_RS18895	COG3293	Transposase
B1F85_RS18900	COG0778	Nitroreductase
B1F85_RS18910	COG3609	addiction module antidote protein, CC2985 family
B1F85_RS18920	COG1484	DNA-dependent DNA replication
B1F85_RS18955	COG1309	transcriptional regulator
B1F85_RS18960	COG0456	acetyltransferase
B1F85_RS18965	COG1132	(ABC) transporter
B1F85_RS18970	COG2207	Transcriptional regulator
B1F85_RS18975	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS18980	COG2207	Transcriptional regulator
B1F85_RS18990	COG1309	transcriptional regulator
B1F85_RS18995	COG1902	pentaerythritol trinitrate reductase activity
B1F85_RS19005	COG0702	epimerase
B1F85_RS19015	COG0583	DNA-binding transcription factor activity
B1F85_RS19025	COG1126	abc transporter atp-binding protein
B1F85_RS19035	COG0765	amino acid transport
B1F85_RS19055	COG0601	transmembrane transport
B1F85_RS19060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS19100	COG1335	isochorismatase
B1F85_RS19115	COG1196	nuclear chromosome segregation
B1F85_RS19175	COG2205	protein histidine kinase activity
B1F85_RS19180	COG0745	RESPONSE REGULATOR receiver
B1F85_RS19225	COG1022	Amp-dependent synthetase and ligase
B1F85_RS19235	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS19240	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS19275	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B1F85_RS19290	COG1129	ABC transporter
B1F85_RS19310	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B1F85_RS19325	COG2207	Transcriptional regulator
B1F85_RS19325	COG1609	Transcriptional regulator
B1F85_RS19330	COG2115	Belongs to the xylose isomerase family
B1F85_RS19335	COG4213	ABC transporter substrate-binding protein
B1F85_RS19340	COG1129	ABC transporter
B1F85_RS19345	COG4214	carbohydrate transport
B1F85_RS19400	COG0673	inositol 2-dehydrogenase activity
B1F85_RS19425	COG2200	EAL domain
B1F85_RS19425	COG2202	Pas domain
B1F85_RS19425	COG2199	diguanylate cyclase activity
B1F85_RS19440	COG3121	Chaperone
B1F85_RS19445	COG3188	usher protein
B1F85_RS19455	COG3121	Chaperone
B1F85_RS19475	COG0322	excinuclease ABC activity
B1F85_RS19480	COG2197	response regulator
B1F85_RS19500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
B1F85_RS19505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F85_RS19510	COG4166	transmembrane transport
B1F85_RS19515	COG4174	ABC transporter (Permease)
B1F85_RS19520	COG4239	(ABC) transporter, permease
B1F85_RS19525	COG4172	Belongs to the ABC transporter superfamily
B1F85_RS19545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B1F85_RS19590	COG1064	alcohol dehydrogenase
B1F85_RS19655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS19670	COG1253	flavin adenine dinucleotide binding
B1F85_RS19680	COG0583	DNA-binding transcription factor activity
B1F85_RS19695	COG3132	Protein of unknown function, DUF480
B1F85_RS19700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B1F85_RS19720	COG1686	Belongs to the peptidase S11 family
B1F85_RS19745	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS19760	COG2267	carboxylic ester hydrolase activity
B1F85_RS19765	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS19790	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B1F85_RS19795	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B1F85_RS19800	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1F85_RS19810	COG3842	ATPase activity
B1F85_RS19815	COG0583	DNA-binding transcription factor activity
B1F85_RS19825	COG0583	DNA-binding transcription factor activity
B1F85_RS19830	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS19845	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B1F85_RS19855	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B1F85_RS19860	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B1F85_RS19865	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B1F85_RS19870	COG2080	2 iron, 2 sulfur cluster binding
B1F85_RS19875	COG0579	oxidoreductase
B1F85_RS19880	COG4251	negative regulation of phosphorylation
B1F85_RS19910	COG4792	protein secretion
B1F85_RS19915	COG4791	protein targeting
B1F85_RS19925	COG4790	Type iii secretion
B1F85_RS19930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B1F85_RS19955	COG4669	(LipO)protein
B1F85_RS19985	COG4964	Belongs to the GSP D family
B1F85_RS19990	COG4789	Type iii secretion
B1F85_RS19995	COG4789	Type iii secretion
B1F85_RS20050	COG3713	MltA-interacting MipA family protein
B1F85_RS20055	COG0745	RESPONSE REGULATOR receiver
B1F85_RS20060	COG0642	Histidine kinase
B1F85_RS20070	COG1301	dicarboxylic acid transport
B1F85_RS20080	COG1609	Transcriptional regulator
B1F85_RS20085	COG1172	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS20090	COG1129	ABC transporter
B1F85_RS20095	COG1879	ABC-type sugar transport system periplasmic component
B1F85_RS20100	COG3386	PFAM SMP-30 Gluconolaconase
B1F85_RS20110	COG0803	Belongs to the bacterial solute-binding protein 9 family
B1F85_RS20120	COG1121	(ABC) transporter
B1F85_RS20140	COG0384	phenazine biosynthesis protein PhzF
B1F85_RS20145	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1F85_RS20150	COG0417	DNA replication proofreading
B1F85_RS20155	COG0517	IMP dehydrogenase activity
B1F85_RS20170	COG0583	DNA-binding transcription factor activity
B1F85_RS20175	COG0840	transmembrane signaling receptor activity
B1F85_RS20190	COG2175	clavaminate synthase activity
B1F85_RS20195	COG1247	-acetyltransferase
B1F85_RS20200	COG0124	histidyl-tRNA synthetase
B1F85_RS20205	COG0583	DNA-binding transcription factor activity
B1F85_RS20210	COG0604	alcohol dehydrogenase
B1F85_RS20230	COG1999	signal sequence binding
B1F85_RS20235	COG4206	TonB-dependent receptor
B1F85_RS20240	COG4977	sequence-specific DNA binding
B1F85_RS20245	COG4771	TonB-dependent receptor
B1F85_RS20250	COG1132	(ABC) transporter
B1F85_RS20250	COG2375	cellular response to nickel ion
B1F85_RS20260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1F85_RS20260	COG3433	isochorismatase activity
B1F85_RS20260	COG2226	methyltransferase
B1F85_RS20285	COG1021	2,3-dihydroxybenzoate-AMP ligase
B1F85_RS20305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS20315	COG5001	Diguanylate cyclase
B1F85_RS20330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F85_RS20360	COG0069	glutamate synthase activity
B1F85_RS20365	COG2218	PFAM glutamate synthase alpha subunit domain protein
B1F85_RS20370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B1F85_RS20395	COG1469	GTP cyclohydrolase I activity
B1F85_RS20400	COG0583	DNA-binding transcription factor activity
B1F85_RS20415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS20420	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS20425	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS20440	COG0154	amidase activity
B1F85_RS20445	COG4993	Dehydrogenase
B1F85_RS20465	COG0840	transmembrane signaling receptor activity
B1F85_RS20550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B1F85_RS20565	COG0446	pyridine nucleotide-disulphide oxidoreductase
B1F85_RS20565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1F85_RS20575	COG0840	transmembrane signaling receptor activity
B1F85_RS20655	COG3328	transposase activity
B1F85_RS20660	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F85_RS20670	COG1120	ATPase activity
B1F85_RS20675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS20680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS20685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B1F85_RS20690	COG4264	IucA IucC family
B1F85_RS20700	COG4264	IucA IucC family
B1F85_RS20705	COG2814	Major facilitator Superfamily
B1F85_RS20710	COG0019	diaminopimelate decarboxylase activity
B1F85_RS20715	COG4264	IucA IucC family
B1F85_RS20720	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS20730	COG3712	iron ion homeostasis
B1F85_RS20735	COG1595	DNA-templated transcription, initiation
B1F85_RS20745	COG1595	DNA-templated transcription, initiation
B1F85_RS20755	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS20760	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS20765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS20770	COG0601	transmembrane transport
B1F85_RS20845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F85_RS20850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B1F85_RS20890	COG1253	flavin adenine dinucleotide binding
B1F85_RS20920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F85_RS20935	COG1414	Transcriptional regulator
B1F85_RS20940	COG3842	ATPase activity
B1F85_RS20945	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1F85_RS20950	COG1177	transmembrane transport
B1F85_RS20980	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B1F85_RS21010	COG0028	Belongs to the TPP enzyme family
B1F85_RS21015	COG0768	penicillin binding
B1F85_RS21020	COG1733	regulation of RNA biosynthetic process
B1F85_RS21025	COG0702	epimerase
B1F85_RS21070	COG2271	Major facilitator Superfamily
B1F85_RS21080	COG2271	Major facilitator Superfamily
B1F85_RS21100	COG3387	PFAM Glycoside hydrolase 15-related
B1F85_RS21110	COG0667	Aldo Keto reductase
B1F85_RS21125	COG2066	Belongs to the glutaminase family
B1F85_RS21130	COG0235	Class ii aldolase
B1F85_RS21190	COG0045	succinate-CoA ligase (ADP-forming) activity
B1F85_RS21195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1F85_RS21210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B1F85_RS21215	COG1053	succinate dehydrogenase
B1F85_RS21220	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
B1F85_RS21225	COG2009	succinate dehydrogenase
B1F85_RS21250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1F85_RS21285	COG2207	Transcriptional regulator
B1F85_RS21345	COG1484	DNA-dependent DNA replication
B1F85_RS21370	COG1064	alcohol dehydrogenase
B1F85_RS21375	COG1064	alcohol dehydrogenase
B1F85_RS21380	COG1414	Transcriptional regulator
B1F85_RS21385	COG2271	Major facilitator Superfamily
B1F85_RS21395	COG4948	Mandelate Racemase Muconate Lactonizing
B1F85_RS21400	COG0800	Aldolase
B1F85_RS21405	COG3734	2-keto-3-deoxy-galactonokinase
B1F85_RS21415	COG0473	3-isopropylmalate dehydrogenase activity
B1F85_RS21420	COG0066	3-isopropylmalate dehydratase activity
B1F85_RS21425	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B1F85_RS21445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1F85_RS21490	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B1F85_RS21510	COG0556	nucleotide-excision repair
B1F85_RS21525	COG2366	antibiotic biosynthetic process
B1F85_RS21530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS21535	COG1136	(ABC) transporter
B1F85_RS21535	COG0577	efflux transmembrane transporter activity
B1F85_RS21540	COG1538	Outer membrane efflux protein
B1F85_RS21585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B1F85_RS21590	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
B1F85_RS21625	COG1289	transmembrane transporter activity
B1F85_RS21650	COG3485	protocatechuate 3,4-dioxygenase
B1F85_RS21655	COG4829	muconolactone delta-isomerase
B1F85_RS21660	COG4948	Mandelate Racemase Muconate Lactonizing
B1F85_RS21665	COG0543	2 iron, 2 sulfur cluster binding
B1F85_RS21665	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1F85_RS21670	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
B1F85_RS21675	COG4638	Rieske (2fe-2S)
B1F85_RS21745	COG1522	sequence-specific DNA binding
B1F85_RS21755	COG2866	Carboxypeptidase
B1F85_RS21780	COG0217	transcriptional regulatory protein
B1F85_RS21785	COG1024	Enoyl-CoA hydratase
B1F85_RS21790	COG0183	Belongs to the thiolase family
B1F85_RS21855	COG2995	paraquat-inducible protein a
B1F85_RS21860	COG2995	paraquat-inducible protein a
B1F85_RS21865	COG3008	intermembrane lipid transfer
B1F85_RS21880	COG0583	DNA-binding transcription factor activity
B1F85_RS21885	COG1741	Belongs to the pirin family
B1F85_RS21890	COG0667	Aldo Keto reductase
B1F85_RS21895	COG0583	DNA-binding transcription factor activity
B1F85_RS21920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B1F85_RS21925	COG1349	DNA-binding transcription factor activity
B1F85_RS21930	COG0154	amidase activity
B1F85_RS21945	COG0583	DNA-binding transcription factor activity
B1F85_RS21950	COG2814	Major facilitator Superfamily
B1F85_RS21960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F85_RS21975	COG2070	2-Nitropropane dioxygenase
B1F85_RS21985	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F85_RS21990	COG0473	3-isopropylmalate dehydrogenase activity
B1F85_RS21990	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
B1F85_RS21995	COG0473	3-isopropylmalate dehydrogenase activity
B1F85_RS22000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B1F85_RS22005	COG3328	transposase activity
B1F85_RS22040	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS22050	COG3210	domain, Protein
B1F85_RS22060	COG0583	DNA-binding transcription factor activity
B1F85_RS22075	COG0659	secondary active sulfate transmembrane transporter activity
B1F85_RS22080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1F85_RS22125	COG5002	protein histidine kinase activity
B1F85_RS22125	COG3447	MASE1 domain protein
B1F85_RS22125	COG5001	Diguanylate cyclase
B1F85_RS22135	COG0745	RESPONSE REGULATOR receiver
B1F85_RS22140	COG0406	alpha-ribazole phosphatase activity
B1F85_RS22155	COG4948	Mandelate Racemase Muconate Lactonizing
B1F85_RS22160	COG4166	transmembrane transport
B1F85_RS22165	COG0601	transmembrane transport
B1F85_RS22170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B1F85_RS22175	COG0444	Belongs to the ABC transporter superfamily
B1F85_RS22180	COG4608	Belongs to the ABC transporter superfamily
B1F85_RS22195	COG2186	Transcriptional regulator
B1F85_RS22200	COG1609	Transcriptional regulator
B1F85_RS22210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS22215	COG1120	ATPase activity
B1F85_RS22220	COG0826	peptidase U32
B1F85_RS22245	COG2146	nitrite reductase [NAD(P)H] activity
B1F85_RS22245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F85_RS22250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B1F85_RS22250	COG2146	nitrite reductase [NAD(P)H] activity
B1F85_RS22265	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1F85_RS22270	COG0581	inorganic phosphate transmembrane transporter activity
B1F85_RS22275	COG0573	inorganic phosphate transmembrane transporter activity
B1F85_RS22280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B1F85_RS22350	COG0583	DNA-binding transcription factor activity
B1F85_RS22355	COG3180	Ammonia monooxygenase
B1F85_RS22360	COG2942	2-epimerase
B1F85_RS22370	COG1929	Belongs to the glycerate kinase type-1 family
B1F85_RS22375	COG3835	regulator
B1F85_RS22405	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F85_RS22435	COG2116	formate transmembrane transporter activity
B1F85_RS22440	COG0745	RESPONSE REGULATOR receiver
B1F85_RS22445	COG5002	protein histidine kinase activity
B1F85_RS22450	COG2267	carboxylic ester hydrolase activity
B1F85_RS22460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B1F85_RS22465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F85_RS22475	COG2814	Major facilitator Superfamily
B1F85_RS22490	COG1450	Type ii and iii secretion system protein
B1F85_RS22510	COG3156	type II secretion system protein K
B1F85_RS22525	COG2165	general secretion pathway protein
B1F85_RS22530	COG2165	general secretion pathway protein
B1F85_RS22535	COG1459	type II secretion system
B1F85_RS22540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B1F85_RS22550	COG1472	Belongs to the glycosyl hydrolase 3 family
B1F85_RS22555	COG1309	transcriptional regulator
B1F85_RS22570	COG0583	DNA-binding transcription factor activity
B1F85_RS22575	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS22620	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
B1F85_RS22645	COG1111	helicase
B1F85_RS22645	COG1205	dead DEAH box helicase
B1F85_RS22650	COG0583	DNA-binding transcription factor activity
B1F85_RS22685	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B1F85_RS22690	COG0435	Glutathione S-transferase
B1F85_RS22695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B1F85_RS22695	COG1648	precorrin-2 dehydrogenase activity
B1F85_RS22700	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B1F85_RS22705	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B1F85_RS22710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B1F85_RS22715	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B1F85_RS22720	COG1674	ftsk spoiiie
B1F85_RS22730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B1F85_RS22735	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
B1F85_RS22740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B1F85_RS22745	COG0542	response to heat
B1F85_RS22750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B1F85_RS22755	COG1278	Cold shock
B1F85_RS22770	COG0482	sulfurtransferase activity
B1F85_RS22775	COG2915	High frequency lysogenization protein hflD homolog
B1F85_RS22785	COG2850	peptidyl-arginine hydroxylation
B1F85_RS22790	COG2153	protein acetylation
B1F85_RS22805	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1F85_RS22810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1F85_RS22815	COG0649	NAD binding
B1F85_RS22815	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1F85_RS22830	COG1034	ATP synthesis coupled electron transport
B1F85_RS22835	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B1F85_RS22840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B1F85_RS22850	COG0713	ATP synthesis coupled electron transport
B1F85_RS22870	COG0628	permease
B1F85_RS22905	COG0720	synthase
B1F85_RS22970	COG1215	transferase activity, transferring glycosyl groups
B1F85_RS23005	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS23015	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B1F85_RS23025	COG0431	NADPH-dependent FMN reductase
B1F85_RS23040	COG0583	DNA-binding transcription factor activity
B1F85_RS23075	COG2031	fatty acid transporter
B1F85_RS23080	COG2329	Antibiotic biosynthesis monooxygenase
B1F85_RS23085	COG0504	CTP synthase activity
B1F85_RS23090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B1F85_RS23095	COG0584	glycerophosphoryl diester phosphodiesterase
B1F85_RS23105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F85_RS23115	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B1F85_RS23120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B1F85_RS23125	COG3829	transcription factor binding
B1F85_RS23155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B1F85_RS23155	COG2111	Na H antiporter
B1F85_RS23160	COG1006	Multisubunit Na H antiporter MnhC subunit
B1F85_RS23165	COG0651	ATP synthesis coupled electron transport
B1F85_RS23175	COG2212	antiporter activity
B1F85_RS23180	COG1320	monovalent cation:proton antiporter activity
B1F85_RS23215	COG4211	Belongs to the binding-protein-dependent transport system permease family
B1F85_RS23220	COG1129	ABC transporter
B1F85_RS23235	COG0277	FAD linked oxidase domain protein
B1F85_RS23240	COG0247	lactate metabolic process
B1F85_RS23250	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1F85_RS23260	COG1609	Transcriptional regulator
B1F85_RS23265	COG3265	gluconokinase activity
B1F85_RS23280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F85_RS23305	COG0456	acetyltransferase
B1F85_RS23360	COG4191	Histidine kinase
B1F85_RS23360	COG0784	Response regulator, receiver
B1F85_RS23380	COG0583	DNA-binding transcription factor activity
B1F85_RS23395	COG2223	nitrite transmembrane transporter activity
B1F85_RS23405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B1F85_RS23410	COG0659	secondary active sulfate transmembrane transporter activity
B1F85_RS23420	COG2169	Transcriptional regulator
B1F85_RS23420	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B1F85_RS23425	COG0672	)-iron permease
B1F85_RS23430	COG2822	iron ion transport
B1F85_RS23435	COG2837	iron assimilation
B1F85_RS23440	COG2822	iron ion transport
B1F85_RS23505	COG1121	(ABC) transporter
B1F85_RS23510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1F85_RS23560	COG2205	protein histidine kinase activity
B1F85_RS23560	COG0784	Response regulator, receiver
B1F85_RS23575	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B1F85_RS23580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B1F85_RS23590	COG3706	GGDEF domain
B1F85_RS23590	COG2203	Gaf domain
B1F85_RS23590	COG5001	Diguanylate cyclase
B1F85_RS23590	COG4251	negative regulation of phosphorylation
B1F85_RS23600	COG3706	GGDEF domain
B1F85_RS23635	COG5002	protein histidine kinase activity
B1F85_RS23655	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B1F85_RS23665	COG2204	response regulator
B1F85_RS23695	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1F85_RS23695	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B1F85_RS23700	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1F85_RS23705	COG1136	(ABC) transporter
B1F85_RS23710	COG4591	ABC-type transport system involved in lipoprotein release permease component
B1F85_RS23720	COG0584	glycerophosphoryl diester phosphodiesterase
B1F85_RS23725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B1F85_RS23730	COG1477	protein flavinylation
B1F85_RS23750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B1F85_RS23760	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B1F85_RS23765	COG1335	isochorismatase
B1F85_RS23770	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS23840	COG0598	Magnesium transport protein CorA
B1F85_RS23845	COG0519	Catalyzes the synthesis of GMP from XMP
B1F85_RS23845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B1F85_RS23855	COG1305	Transglutaminase-like
B1F85_RS23865	COG2308	Evidence 4 Homologs of previously reported genes of
B1F85_RS23885	COG1368	sulfuric ester hydrolase activity
B1F85_RS23890	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B1F85_RS23925	COG2197	response regulator
B1F85_RS23930	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
B1F85_RS23935	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B1F85_RS23940	COG0235	Class ii aldolase
B1F85_RS23950	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B1F85_RS23980	COG2840	Smr protein MutS2
B1F85_RS23995	COG0302	gtp cyclohydrolase
B1F85_RS24010	COG0625	glutathione transferase activity
B1F85_RS24015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B1F85_RS24025	COG3135	benzoate transporter
B1F85_RS24030	COG1619	proteins homologs of microcin C7 resistance protein MccF
B1F85_RS24035	COG2130	NADP-dependent
B1F85_RS24045	COG0284	orotidine-5'-phosphate decarboxylase activity
B1F85_RS24070	COG3123	guanosine phosphorylase activity
B1F85_RS24075	COG1132	(ABC) transporter
B1F85_RS24085	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F85_RS24090	COG0425	Belongs to the sulfur carrier protein TusA family
B1F85_RS24095	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
B1F85_RS24105	COG0840	transmembrane signaling receptor activity
B1F85_RS24155	COG3278	Belongs to the heme-copper respiratory oxidase family
B1F85_RS24170	COG2010	Cytochrome c
B1F85_RS24195	COG2217	Heavy metal translocating P-type atpase
B1F85_RS24220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B1F85_RS24225	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B1F85_RS24235	COG0835	chemotaxis
B1F85_RS24245	COG1192	Involved in chromosome partitioning
B1F85_RS24255	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B1F85_RS24260	COG2201	protein-glutamate methylesterase activity
B1F85_RS24265	COG2198	Histidine kinase
B1F85_RS24265	COG0784	Response regulator, receiver
B1F85_RS24265	COG0643	Histidine kinase
B1F85_RS24270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
B1F85_RS24295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1F85_RS24300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B1F85_RS24310	COG1987	bacterial-type flagellum assembly
B1F85_RS24365	COG0745	RESPONSE REGULATOR receiver
B1F85_RS24400	COG1677	Flagellar hook-basal body complex protein FliE
B1F85_RS24430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B1F85_RS24445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1F85_RS24450	COG1216	Glycosyl transferase, family 2
B1F85_RS24450	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS24455	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS24455	COG1216	Glycosyl transferase, family 2
B1F85_RS24475	COG1706	bacterial-type flagellum-dependent cell motility
B1F85_RS24480	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B1F85_RS24490	COG4787	bacterial-type flagellum-dependent cell motility
B1F85_RS24510	COG1749	Flagellar hook protein flgE
B1F85_RS24515	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B1F85_RS24525	COG1815	bacterial-type flagellum-dependent cell motility
B1F85_RS24570	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
B1F85_RS24575	COG0583	DNA-binding transcription factor activity
B1F85_RS24580	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B1F85_RS24585	COG0784	Response regulator, receiver
B1F85_RS24585	COG0835	chemotaxis
B1F85_RS24605	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B1F85_RS24610	COG0477	Major facilitator Superfamily
B1F85_RS24635	COG2814	Major facilitator Superfamily
B1F85_RS24640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B1F85_RS24650	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS24670	COG4991	sh3 domain protein
B1F85_RS24675	COG1611	Belongs to the LOG family
B1F85_RS24690	COG2271	Major facilitator Superfamily
B1F85_RS24715	COG4251	negative regulation of phosphorylation
B1F85_RS24755	COG0642	Histidine kinase
B1F85_RS24760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS24765	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS24770	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS24775	COG5383	Protein conserved in bacteria
B1F85_RS24790	COG0583	DNA-binding transcription factor activity
B1F85_RS24795	COG1760	l-serine dehydratase
B1F85_RS24810	COG0583	DNA-binding transcription factor activity
B1F85_RS24830	COG1473	amidohydrolase
B1F85_RS24835	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS24845	COG0583	DNA-binding transcription factor activity
B1F85_RS24850	COG1063	alcohol dehydrogenase
B1F85_RS24865	COG1953	Uracil, thiamine, allantoin
B1F85_RS24870	COG4191	Histidine kinase
B1F85_RS24870	COG0784	Response regulator, receiver
B1F85_RS24880	COG0596	Alpha beta hydrolase
B1F85_RS24890	COG1484	DNA-dependent DNA replication
B1F85_RS24935	COG2239	Acts as a magnesium transporter
B1F85_RS24960	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F85_RS24965	COG0527	aspartate kinase activity
B1F85_RS24970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B1F85_RS24975	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
B1F85_RS24980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B1F85_RS24990	COG2988	succinylglutamate desuccinylase activity
B1F85_RS25000	COG3724	N-succinylarginine dihydrolase activity
B1F85_RS25005	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS25020	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B1F85_RS25055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS25060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B1F85_RS25080	COG2154	pterin-4-alpha-carbinolamine dehydratase
B1F85_RS25125	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B1F85_RS25135	COG0009	L-threonylcarbamoyladenylate synthase
B1F85_RS25140	COG0613	PHP domain protein
B1F85_RS25145	COG2917	probably involved in intracellular septation
B1F85_RS25150	COG2350	Protein conserved in bacteria
B1F85_RS25160	COG0745	RESPONSE REGULATOR receiver
B1F85_RS25175	COG0642	Histidine kinase
B1F85_RS25185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B1F85_RS25215	COG1116	anion transmembrane transporter activity
B1F85_RS25220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1F85_RS25230	COG0583	DNA-binding transcription factor activity
B1F85_RS25250	COG2358	TRAP transporter, solute receptor (TAXI family
B1F85_RS25255	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS25260	COG0583	DNA-binding transcription factor activity
B1F85_RS25265	COG1741	Belongs to the pirin family
B1F85_RS25305	COG1956	GAF domain-containing protein
B1F85_RS25320	COG0386	Belongs to the glutathione peroxidase family
B1F85_RS25325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1F85_RS25330	COG0436	Aminotransferase
B1F85_RS25335	COG0501	Belongs to the peptidase M48B family
B1F85_RS25345	COG0500	methyltransferase
B1F85_RS25350	COG3384	dioxygenase
B1F85_RS25370	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B1F85_RS25375	COG5457	Domain of unknown function (DUF1127)
B1F85_RS25380	COG0583	DNA-binding transcription factor activity
B1F85_RS25390	COG1846	Transcriptional regulator
B1F85_RS25395	COG1764	response to oxidative stress
B1F85_RS25400	COG0657	acetylesterase activity
B1F85_RS25405	COG3328	transposase activity
B1F85_RS25415	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B1F85_RS25420	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B1F85_RS25445	COG0814	amino acid
B1F85_RS25460	COG0814	amino acid
B1F85_RS25465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B1F85_RS25475	COG1555	photosystem II stabilization
B1F85_RS25485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B1F85_RS25495	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
B1F85_RS25505	COG0776	regulation of translation
B1F85_RS25515	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B1F85_RS25520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B1F85_RS25530	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B1F85_RS25540	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B1F85_RS25545	COG0402	S-adenosylhomocysteine deaminase activity
B1F85_RS25550	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1F85_RS25555	COG0546	phosphoglycolate phosphatase activity
B1F85_RS25560	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS25575	COG5001	Diguanylate cyclase
B1F85_RS25575	COG5002	protein histidine kinase activity
B1F85_RS25590	COG1054	Belongs to the UPF0176 family
B1F85_RS25595	COG0271	Belongs to the BolA IbaG family
B1F85_RS25605	COG0114	fumarate hydratase activity
B1F85_RS25615	COG0697	spore germination
B1F85_RS25705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B1F85_RS25715	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B1F85_RS25725	COG1492	cobalamin metabolic process
B1F85_RS25740	COG0778	Nitroreductase
B1F85_RS25745	COG1797	cobyrinic acid a,c-diamide synthase activity
B1F85_RS25760	COG0791	NLP P60 protein
B1F85_RS25765	COG0791	NLP P60 protein
B1F85_RS25765	COG1388	LysM domain
B1F85_RS25770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1F85_RS25780	COG0628	permease
B1F85_RS25795	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B1F85_RS25800	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B1F85_RS25820	COG3956	TIGRFAM MazG family protein
B1F85_RS25825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B1F85_RS25830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B1F85_RS25855	COG3118	belongs to the thioredoxin family
B1F85_RS25860	COG1393	Belongs to the ArsC family
B1F85_RS25870	COG2818	Glycosylase
B1F85_RS25875	COG0037	tRNA processing
B1F85_RS25880	COG3091	SprT-like family
B1F85_RS25885	COG1301	dicarboxylic acid transport
B1F85_RS25935	COG2205	protein histidine kinase activity
B1F85_RS25945	COG0745	RESPONSE REGULATOR receiver
B1F85_RS25955	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B1F85_RS25995	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B1F85_RS26015	COG0542	response to heat
B1F85_RS26035	COG0121	glutamine amidotransferase
B1F85_RS26045	COG1770	oligopeptidase
B1F85_RS26060	COG2132	Multicopper oxidase
B1F85_RS26065	COG3667	copper resistance
B1F85_RS26080	COG2983	Belongs to the UPF0260 family
B1F85_RS26095	COG3100	YcgL domain-containing protein
B1F85_RS26105	COG2194	sulfuric ester hydrolase activity
B1F85_RS26110	COG0281	malic enzyme
B1F85_RS26155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B1F85_RS26160	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1F85_RS26165	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
B1F85_RS26170	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B1F85_RS26180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B1F85_RS26190	COG0425	Belongs to the sulfur carrier protein TusA family
B1F85_RS26200	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B1F85_RS26230	COG4774	siderophore transport
B1F85_RS26485	COG0542	response to heat
B1F85_RS26535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B1F85_RS26565	COG4969	Belongs to the N-Me-Phe pilin family
B1F85_RS26575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B1F85_RS26580	COG1047	Peptidyl-prolyl cis-trans
B1F85_RS26585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B1F85_RS26590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B1F85_RS26595	COG0196	riboflavin kinase activity
B1F85_RS26605	COG0268	Binds directly to 16S ribosomal RNA
B1F85_RS26610	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B1F85_RS26615	COG4372	Transposase
B1F85_RS26635	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS26655	COG2982	Protein involved in outer membrane biogenesis
B1F85_RS26665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B1F85_RS26670	COG0830	nickel cation binding
B1F85_RS26675	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
B1F85_RS26690	COG4221	oxidoreductase activity
B1F85_RS26725	COG0583	DNA-binding transcription factor activity
B1F85_RS26730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B1F85_RS26735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B1F85_RS26755	COG2308	Evidence 4 Homologs of previously reported genes of
B1F85_RS26755	COG2307	Protein conserved in bacteria
B1F85_RS26770	COG1032	radical SAM domain protein
B1F85_RS26775	COG0305	Participates in initiation and elongation during chromosome replication
B1F85_RS26780	COG0359	binds to the 23S rRNA
B1F85_RS26790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B1F85_RS26795	COG0360	Binds together with S18 to 16S ribosomal RNA
B1F85_RS26800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B1F85_RS26805	COG0557	exoribonuclease II activity
B1F85_RS26830	COG0840	transmembrane signaling receptor activity
B1F85_RS26835	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B1F85_RS26840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B1F85_RS26845	COG0330	HflC and HflK could
B1F85_RS26850	COG0330	HflC and HflK could
B1F85_RS26855	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B1F85_RS26860	COG1923	regulation of RNA biosynthetic process
B1F85_RS26865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B1F85_RS26870	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B1F85_RS26875	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1F85_RS26880	COG0802	atpase or kinase
B1F85_RS26885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B1F85_RS26885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B1F85_RS26895	COG2860	membrane
B1F85_RS26900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
B1F85_RS26905	COG1162	GTPase activity
B1F85_RS26925	COG0688	phosphatidylethanolamine metabolic process
B1F85_RS26935	COG0560	Phosphoserine phosphatase
B1F85_RS26935	COG3830	Belongs to the UPF0237 family
B1F85_RS26960	COG3577	Aspartyl protease
B1F85_RS26975	COG3150	esterase
B1F85_RS26980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1F85_RS26995	COG0494	nUDIX hydrolase
B1F85_RS27015	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B1F85_RS27020	COG1538	Outer membrane efflux protein
B1F85_RS27025	COG1519	Transferase
B1F85_RS27040	COG0667	Aldo Keto reductase
B1F85_RS27050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B1F85_RS27050	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B1F85_RS27055	COG1132	(ABC) transporter
B1F85_RS27095	COG2192	nodulation
B1F85_RS27135	COG0438	transferase activity, transferring glycosyl groups
B1F85_RS27145	COG0859	PFAM glycosyl transferase family 9
B1F85_RS27150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B1F85_RS27165	COG0513	Belongs to the DEAD box helicase family
B1F85_RS27175	COG2081	HI0933 family
B1F85_RS27180	COG1289	transmembrane transporter activity
B1F85_RS27190	COG2153	protein acetylation
B1F85_RS27200	COG1451	nucleotide metabolic process
B1F85_RS27215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B1F85_RS27220	COG0506	proline dehydrogenase activity
B1F85_RS27220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1F85_RS27220	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B1F85_RS27225	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS27240	COG3263	regulation of cellular component size
B1F85_RS27245	COG3264	Mechanosensitive ion channel
B1F85_RS27245	COG1196	nuclear chromosome segregation
B1F85_RS27260	COG4104	PAAR repeat-containing protein
B1F85_RS27285	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS27290	COG2433	Pfam Transposase IS66
B1F85_RS27325	COG1802	Transcriptional regulator
B1F85_RS27330	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
B1F85_RS27345	COG0643	Histidine kinase
B1F85_RS27345	COG0784	Response regulator, receiver
B1F85_RS27345	COG2198	Histidine kinase
B1F85_RS27370	COG0189	ligase activity
B1F85_RS27380	COG1678	Uncharacterized ACR, COG1678
B1F85_RS27385	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B1F85_RS27390	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B1F85_RS27395	COG0540	Belongs to the ATCase OTCase family
B1F85_RS27400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B1F85_RS27410	COG0791	NLP P60 protein
B1F85_RS27440	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1F85_RS27445	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B1F85_RS27445	COG2813	Specifically methylates the guanine in position
B1F85_RS27450	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B1F85_RS27455	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B1F85_RS27485	COG0129	dihydroxy-acid dehydratase activity
B1F85_RS27490	COG0436	Aminotransferase
B1F85_RS27500	COG2084	Dehydrogenase
B1F85_RS27505	COG3395	kinase activity
B1F85_RS27510	COG0235	Class ii aldolase
B1F85_RS27515	COG2610	gluconate transmembrane transporter activity
B1F85_RS27520	COG3622	Belongs to the hyi family
B1F85_RS27530	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B1F85_RS27540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B1F85_RS27545	COG0513	Belongs to the DEAD box helicase family
B1F85_RS27585	COG2353	YceI-like domain
B1F85_RS27590	COG3038	cytochrome b561
B1F85_RS27610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B1F85_RS27615	COG1272	protein, Hemolysin III
B1F85_RS27635	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B1F85_RS27655	COG3052	prosthetic group binding
B1F85_RS27660	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
B1F85_RS27675	COG1192	Involved in chromosome partitioning
B1F85_RS27690	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1F85_RS27695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B1F85_RS27760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1F85_RS27770	COG1028	Short-chain dehydrogenase reductase Sdr
B1F85_RS27775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B1F85_RS27780	COG0583	DNA-binding transcription factor activity
B1F85_RS27785	COG2814	Major facilitator Superfamily
B1F85_RS27810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B1F85_RS27820	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B1F85_RS27835	COG0154	amidase activity
B1F85_RS27840	COG0493	'glutamate synthase
B1F85_RS27845	COG0067	glutamate synthase
B1F85_RS27845	COG0069	glutamate synthase activity
B1F85_RS27845	COG0070	glutamate synthase
B1F85_RS27860	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B1F85_RS27865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B1F85_RS27900	COG0281	malic enzyme
B1F85_RS27910	COG0254	rRNA binding
B1F85_RS27915	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B1F85_RS27920	COG0018	arginyl-trna synthetase
B1F85_RS27930	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B1F85_RS27935	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B1F85_RS27980	COG2226	methyltransferase
B1F85_RS27990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B1F85_RS27995	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B1F85_RS28000	COG0140	phosphoribosyl-ATP diphosphatase activity
B1F85_RS28005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1F85_RS28010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B1F85_RS28025	COG0840	transmembrane signaling receptor activity
B1F85_RS28030	COG0840	transmembrane signaling receptor activity
B1F85_RS28040	COG2943	transferase activity, transferring hexosyl groups
B1F85_RS28045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B1F85_RS28050	COG1490	D-aminoacyl-tRNA deacylase activity
B1F85_RS28055	COG0596	Alpha beta hydrolase
B1F85_RS28060	COG0058	SHG alpha-glucan phosphorylase activity
B1F85_RS28075	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
B1F85_RS28085	COG3040	lipid binding
B1F85_RS28095	COG0402	S-adenosylhomocysteine deaminase activity
B1F85_RS28100	COG2188	Transcriptional regulator
B1F85_RS28110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
B1F85_RS28130	COG1045	serine acetyltransferase
B1F85_RS28135	COG2515	1-aminocyclopropane-1-carboxylate deaminase
B1F85_RS28140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS28145	COG0765	amino acid transport
B1F85_RS28150	COG1126	abc transporter atp-binding protein
B1F85_RS28180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1F85_RS28185	COG2011	ABC-type metal ion transport system permease component
B1F85_RS28195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B1F85_RS28235	COG2175	clavaminate synthase activity
B1F85_RS28250	COG2369	cell adhesion
B1F85_RS28290	COG0662	Cupin 2, conserved barrel domain protein
B1F85_RS28305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B1F85_RS28310	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B1F85_RS28345	COG2271	Major facilitator Superfamily
B1F85_RS28355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1F85_RS28360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B1F85_RS28365	COG0006	proline dipeptidase activity
B1F85_RS28370	COG3079	Belongs to the UPF0149 family
B1F85_RS28390	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B1F85_RS28415	COG4104	PAAR repeat-containing protein
B1F85_RS28455	COG2271	Major facilitator Superfamily
B1F85_RS28465	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B1F85_RS28465	COG0543	2 iron, 2 sulfur cluster binding
B1F85_RS28470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B1F85_RS28485	COG2186	Transcriptional regulator
B1F85_RS28490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B1F85_RS28495	COG0765	amino acid transport
B1F85_RS28500	COG0765	amino acid transport
B1F85_RS28505	COG1126	abc transporter atp-binding protein
B1F85_RS28515	COG0248	Ppx GppA phosphatase
B1F85_RS28520	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B1F85_RS28530	COG0586	Pfam SNARE associated Golgi protein
B1F85_RS28535	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
B1F85_RS28550	COG0659	secondary active sulfate transmembrane transporter activity
B1F85_RS28575	COG1464	Belongs to the NlpA lipoprotein family
B1F85_RS28580	COG2011	ABC-type metal ion transport system permease component
B1F85_RS28585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B1F85_RS28605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B1F85_RS28610	COG1121	(ABC) transporter
B1F85_RS28615	COG0735	belongs to the Fur family
B1F85_RS28620	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
B1F85_RS28625	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B1F85_RS28640	COG4176	ABC-type proline glycine betaine transport system permease component
B1F85_RS28645	COG4175	Glycine betaine
B1F85_RS28650	COG2986	histidine ammonia-lyase
B1F85_RS28655	COG2986	histidine ammonia-lyase
B1F85_RS28665	COG1228	amidohydrolase
B1F85_RS28680	COG0789	Transcriptional regulator
B1F85_RS28700	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B1F85_RS28705	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B1F85_RS28720	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
B1F85_RS28725	COG0494	nUDIX hydrolase
B1F85_RS28740	COG3328	transposase activity
B1F85_RS28760	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B1F85_RS28790	COG4638	Rieske (2fe-2S)
B1F85_RS28865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B1F85_RS28870	COG1025	Belongs to the peptidase M16 family
B1F85_RS28880	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B1F85_RS28885	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
B1F85_RS28895	COG0535	radical SAM domain protein
B1F85_RS28915	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS28920	COG3706	GGDEF domain
B1F85_RS28925	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS28945	COG1073	alpha beta
B1F85_RS28945	COG2226	methyltransferase
B1F85_RS28950	COG0156	8-amino-7-oxononanoate synthase activity
B1F85_RS28955	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B1F85_RS28960	COG1040	competence protein
B1F85_RS28965	COG2005	Transcriptional regulator
B1F85_RS28965	COG3585	molybdate ion transport
B1F85_RS28975	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B1F85_RS28980	COG3842	ATPase activity
B1F85_RS28990	COG1175	transmembrane transport
B1F85_RS29000	COG1609	Transcriptional regulator
B1F85_RS29005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B1F85_RS29025	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B1F85_RS29045	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B1F85_RS29090	COG4175	Glycine betaine
B1F85_RS29090	COG0517	IMP dehydrogenase activity
B1F85_RS29095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B1F85_RS29155	COG0204	Acyl-transferase
B1F85_RS29170	COG0625	glutathione transferase activity
B1F85_RS29185	COG3712	iron ion homeostasis
B1F85_RS29190	COG1595	DNA-templated transcription, initiation
B1F85_RS29195	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B1F85_RS29205	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS29210	COG1309	transcriptional regulator
B1F85_RS29215	COG1160	GTP binding
B1F85_RS29235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B1F85_RS29240	COG2022	thiamine diphosphate biosynthetic process
B1F85_RS29250	COG2363	Small membrane protein
B1F85_RS29255	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B1F85_RS29265	COG2177	Part of the ABC transporter FtsEX involved in
B1F85_RS29270	COG2884	Cell division ATP-binding protein ftsE
B1F85_RS29275	COG0552	protein localization to endoplasmic reticulum
B1F85_RS29280	COG0612	Peptidase, M16
B1F85_RS29285	COG0612	Peptidase, M16
B1F85_RS29290	COG0742	ribosomal rna small subunit methyltransferase
B1F85_RS29305	COG0429	hydrolase of the alpha beta-hydrolase fold
B1F85_RS29325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B1F85_RS29330	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B1F85_RS29340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B1F85_RS29345	COG1639	'signal transduction protein
B1F85_RS29350	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B1F85_RS29375	COG0477	Major facilitator Superfamily
B1F85_RS29385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B1F85_RS29395	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B1F85_RS29400	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
B1F85_RS29405	COG3204	pilus organization
B1F85_RS29415	COG0179	Fumarylacetoacetate (FAA) hydrolase
B1F85_RS29420	COG0277	FAD linked oxidase domain protein
B1F85_RS29425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B1F85_RS29465	COG1177	transmembrane transport
B1F85_RS29470	COG1176	ABC-type spermidine putrescine transport system, permease component I
B1F85_RS29475	COG3842	ATPase activity
B1F85_RS29495	COG0174	glutamine synthetase
B1F85_RS29500	COG0174	glutamine synthetase
B1F85_RS29545	COG1116	anion transmembrane transporter activity
B1F85_RS29550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B1F85_RS29555	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B1F85_RS29560	COG0450	alkyl hydroperoxide reductase
B1F85_RS29570	COG0509	glycine decarboxylation via glycine cleavage system
B1F85_RS29575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B1F85_RS29580	COG1178	ABC-type Fe3 transport system permease component
B1F85_RS29600	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B1F85_RS29605	COG4208	sulfate ABC transporter
B1F85_RS29615	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B1F85_RS29635	COG2199	diguanylate cyclase activity
B1F85_RS29645	COG0745	RESPONSE REGULATOR receiver
B1F85_RS29650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS29655	COG1012	belongs to the aldehyde dehydrogenase family
B1F85_RS29660	COG1280	lysine exporter protein (LysE YggA)
B1F85_RS29720	COG1802	Transcriptional regulator
B1F85_RS29725	COG1914	H( )-stimulated, divalent metal cation uptake system
B1F85_RS29730	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B1F85_RS29735	COG4336	lyase activity
B1F85_RS29740	COG1984	allophanate hydrolase subunit 2
B1F85_RS29745	COG4770	biotin carboxylase activity
B1F85_RS29790	COG2026	Addiction module toxin, RelE StbE family
B1F85_RS29795	COG3077	Addiction module antitoxin, RelB DinJ family
B1F85_RS29830	COG2957	Belongs to the agmatine deiminase family
B1F85_RS29840	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B1F85_RS29845	COG1088	dTDP-glucose 4,6-dehydratase activity
B1F85_RS29870	COG1218	3'(2'),5'-bisphosphate nucleotidase
B1F85_RS29875	COG0494	nUDIX hydrolase
B1F85_RS29880	COG1011	Hydrolase
B1F85_RS29885	COG0583	DNA-binding transcription factor activity
B1F85_RS29890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B1F85_RS29895	COG0243	molybdopterin cofactor binding
B1F85_RS29990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B1F85_RS29995	COG1234	tRNA 3'-trailer cleavage
B1F85_RS30030	COG1484	DNA-dependent DNA replication
B1F85_RS30055	COG1484	DNA-dependent DNA replication
B1F85_RS30085	COG1397	ADP-ribosylglycohydrolase
B1F85_RS30110	COG0668	transmembrane transport
B1F85_RS30120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B1F85_RS30125	COG0667	Aldo Keto reductase
B1F85_RS30130	COG1802	Transcriptional regulator
B1F85_RS30190	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B1F85_RS30195	COG1960	acyl-CoA dehydrogenase activity
B1F85_RS30200	COG0583	DNA-binding transcription factor activity
B1F85_RS30220	COG0427	acetyl-CoA hydrolase
B1F85_RS30275	COG3161	chorismate lyase activity
B1F85_RS30280	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B1F85_RS30295	COG1253	flavin adenine dinucleotide binding
B1F85_RS30300	COG0739	heme binding
B1F85_RS30315	COG0704	Plays a role in the regulation of phosphate uptake
B1F85_RS30320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B1F85_RS30325	COG0573	inorganic phosphate transmembrane transporter activity
B1F85_RS30330	COG0573	inorganic phosphate transmembrane transporter activity
B1F85_RS30380	COG0583	DNA-binding transcription factor activity
B1F85_RS30385	COG1027	Aspartate ammonia-lyase
B1F85_RS30390	COG1115	amino acid carrier protein
B1F85_RS30395	COG0252	asparaginase activity
B1F85_RS30400	COG3781	membrane
B1F85_RS30405	COG2391	methyltransferase activity
B1F85_RS30430	COG0511	ligase activity, forming carbon-carbon bonds
B1F85_RS30430	COG5016	pyruvate
B1F85_RS30435	COG0439	Biotin carboxylase
B1F85_RS30440	COG0583	DNA-binding transcription factor activity
B1F85_RS30450	COG1737	Transcriptional regulator
B1F85_RS30455	COG0210	DNA helicase
B1F85_RS30470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B1F85_RS30470	COG4651	solute:proton antiporter activity
B1F85_RS30475	COG1607	acyl-coa hydrolase
B1F85_RS30480	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
B1F85_RS30490	COG0523	cobalamin synthesis protein
B1F85_RS30515	COG0860	N-Acetylmuramoyl-L-alanine amidase
B1F85_RS30525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B1F85_RS30535	COG2184	nucleotidyltransferase activity
B1F85_RS30540	COG2217	Heavy metal translocating P-type atpase
B1F85_RS30540	COG2608	mercury ion transmembrane transporter activity
B1F85_RS30560	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B1F85_RS30565	COG2267	carboxylic ester hydrolase activity
B1F85_RS30570	COG0671	phosphoesterase, PA-phosphatase related
B1F85_RS30570	COG2453	phosphatase
B1F85_RS30585	COG4589	Belongs to the CDS family
B1F85_RS30595	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B1F85_RS30620	COG4566	intracellular signal transduction
B1F85_RS30625	COG4191	Histidine kinase
B1F85_RS30630	COG1116	anion transmembrane transporter activity
B1F85_RS30640	COG0840	transmembrane signaling receptor activity
B1F85_RS30670	COG0529	Catalyzes the synthesis of activated sulfate
B1F85_RS30680	COG2890	protein-(glutamine-N5) methyltransferase activity
B1F85_RS30690	COG1120	ATPase activity
B1F85_RS30700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B1F85_RS30730	COG0488	(ABC) transporter
B1F85_RS30735	COG0488	(ABC) transporter
B1F85_RS30750	COG1484	DNA-dependent DNA replication
B1F85_RS30765	COG1484	DNA-dependent DNA replication
B1F85_RS30775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B1F85_RS30845	COG3039	Transposase
B1F85_RS30875	COG1196	nuclear chromosome segregation
B1F85_RS30895	COG4372	Transposase
B1F85_RS30910	COG0084	hydrolase, TatD family'
B1F85_RS30940	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS30975	COG5001	Diguanylate cyclase
B1F85_RS30995	COG1649	PFAM Uncharacterised BCR, COG1649
B1F85_RS31020	COG4372	Transposase
B1F85_RS31035	COG3436	PFAM IS66 Orf2 family protein
B1F85_RS31055	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B1F85_RS31060	COG1349	DNA-binding transcription factor activity
B1F85_RS31065	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B1F85_RS31070	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B1F85_RS31075	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B1F85_RS31080	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B1F85_RS31085	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B1F85_RS31090	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B1F85_RS31095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B1F85_RS31105	COG0356	it plays a direct role in the translocation of protons across the membrane
B1F85_RS31110	COG3312	ion transport
B1F85_RS31115	COG1475	DNA binding
B1F85_RS31120	COG1192	Involved in chromosome partitioning
B1F85_RS31125	COG0357	Ribosomal RNA small subunit methyltransferase G
B1F85_RS31130	COG0445	tRNA wobble uridine modification
B1F85_RS31135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B1F85_RS31140	COG0706	membrane insertase activity
B1F85_RS31145	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B1F85_RS31150	COG0594	ribonuclease P activity
B1F85_RS31155	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B1F85_RS31170	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B1F85_RS31180	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B1F85_RS31280	COG2771	luxR family
B1F85_RS31285	COG0512	Glutamine amidotransferase of anthranilate synthase
B1F85_RS31295	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
B1F85_RS31315	COG0697	spore germination
B1F85_RS31520	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B1F85_RS31590	COG4974	Belongs to the 'phage' integrase family
B1F85_RS31620	COG3504	Conjugal transfer protein
B1F85_RS31630	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis