locus-tag	class	description
D9N00_RS00060	COG0697	spore germination
D9N00_RS00080	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
D9N00_RS00090	COG0512	Glutamine amidotransferase of anthranilate synthase
D9N00_RS00095	COG2771	luxR family
D9N00_RS00195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9N00_RS00205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9N00_RS00235	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D9N00_RS00245	COG3504	Conjugal transfer protein
D9N00_RS00275	COG4974	Belongs to the 'phage' integrase family
D9N00_RS00365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9N00_RS00500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D9N00_RS00505	COG0592	DNA-directed DNA polymerase activity
D9N00_RS00510	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9N00_RS00515	COG0187	DNA topoisomerase II activity
D9N00_RS00520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
D9N00_RS00530	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
D9N00_RS00580	COG1484	DNA-dependent DNA replication
D9N00_RS00615	COG1234	tRNA 3'-trailer cleavage
D9N00_RS00620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9N00_RS00720	COG0243	molybdopterin cofactor binding
D9N00_RS00725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D9N00_RS00730	COG0583	DNA-binding transcription factor activity
D9N00_RS00735	COG1011	Hydrolase
D9N00_RS00740	COG0494	nUDIX hydrolase
D9N00_RS00745	COG1218	3'(2'),5'-bisphosphate nucleotidase
D9N00_RS00770	COG1088	dTDP-glucose 4,6-dehydratase activity
D9N00_RS00775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS00790	COG2957	Belongs to the agmatine deiminase family
D9N00_RS00825	COG3077	Addiction module antitoxin, RelB DinJ family
D9N00_RS00830	COG2026	Addiction module toxin, RelE StbE family
D9N00_RS00875	COG4770	biotin carboxylase activity
D9N00_RS00880	COG1984	allophanate hydrolase subunit 2
D9N00_RS00885	COG4336	lyase activity
D9N00_RS00890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9N00_RS00895	COG1914	H( )-stimulated, divalent metal cation uptake system
D9N00_RS00900	COG1802	Transcriptional regulator
D9N00_RS00960	COG1280	lysine exporter protein (LysE YggA)
D9N00_RS00965	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS00970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS00980	COG0745	RESPONSE REGULATOR receiver
D9N00_RS00995	COG2199	diguanylate cyclase activity
D9N00_RS01015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D9N00_RS01025	COG4208	sulfate ABC transporter
D9N00_RS01030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D9N00_RS01050	COG1178	ABC-type Fe3 transport system permease component
D9N00_RS01055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9N00_RS01060	COG0509	glycine decarboxylation via glycine cleavage system
D9N00_RS01070	COG0450	alkyl hydroperoxide reductase
D9N00_RS01080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9N00_RS01085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9N00_RS01090	COG1116	anion transmembrane transporter activity
D9N00_RS01145	COG0174	glutamine synthetase
D9N00_RS01150	COG0174	glutamine synthetase
D9N00_RS01170	COG3842	ATPase activity
D9N00_RS01175	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9N00_RS01180	COG1177	transmembrane transport
D9N00_RS01220	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9N00_RS01225	COG0277	FAD linked oxidase domain protein
D9N00_RS01230	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9N00_RS01240	COG3204	pilus organization
D9N00_RS01245	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D9N00_RS01250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9N00_RS01260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9N00_RS01270	COG0477	Major facilitator Superfamily
D9N00_RS01295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9N00_RS01300	COG1639	'signal transduction protein
D9N00_RS01305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D9N00_RS01315	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D9N00_RS01320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D9N00_RS01340	COG0429	hydrolase of the alpha beta-hydrolase fold
D9N00_RS01355	COG0742	ribosomal rna small subunit methyltransferase
D9N00_RS01360	COG0612	Peptidase, M16
D9N00_RS01365	COG0612	Peptidase, M16
D9N00_RS01370	COG0552	protein localization to endoplasmic reticulum
D9N00_RS01375	COG2884	Cell division ATP-binding protein ftsE
D9N00_RS01380	COG2177	Part of the ABC transporter FtsEX involved in
D9N00_RS01390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9N00_RS01395	COG2363	Small membrane protein
D9N00_RS01405	COG2022	thiamine diphosphate biosynthetic process
D9N00_RS01410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9N00_RS01430	COG1160	GTP binding
D9N00_RS01435	COG1309	transcriptional regulator
D9N00_RS01440	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS01450	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D9N00_RS01455	COG1595	DNA-templated transcription, initiation
D9N00_RS01460	COG3712	iron ion homeostasis
D9N00_RS01475	COG0625	glutathione transferase activity
D9N00_RS01490	COG0204	Acyl-transferase
D9N00_RS01550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9N00_RS01555	COG0517	IMP dehydrogenase activity
D9N00_RS01555	COG4175	Glycine betaine
D9N00_RS01600	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9N00_RS01625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9N00_RS01645	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D9N00_RS01650	COG1609	Transcriptional regulator
D9N00_RS01660	COG1175	transmembrane transport
D9N00_RS01670	COG3842	ATPase activity
D9N00_RS01675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9N00_RS01685	COG2005	Transcriptional regulator
D9N00_RS01685	COG3585	molybdate ion transport
D9N00_RS01695	COG1040	competence protein
D9N00_RS01700	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9N00_RS01705	COG0156	8-amino-7-oxononanoate synthase activity
D9N00_RS01710	COG2226	methyltransferase
D9N00_RS01710	COG1073	alpha beta
D9N00_RS01730	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS01735	COG3706	GGDEF domain
D9N00_RS01740	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS01760	COG0535	radical SAM domain protein
D9N00_RS01770	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
D9N00_RS01775	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9N00_RS01785	COG1025	Belongs to the peptidase M16 family
D9N00_RS01790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9N00_RS01870	COG4695	Portal protein
D9N00_RS02045	COG0484	heat shock protein binding
D9N00_RS02065	COG4215	(ABC) transporter
D9N00_RS02120	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D9N00_RS02125	COG1194	a g-specific adenine glycosylase
D9N00_RS02140	COG2223	nitrite transmembrane transporter activity
D9N00_RS02145	COG1448	Aminotransferase
D9N00_RS02150	COG0131	Imidazoleglycerol-phosphate dehydratase
D9N00_RS02155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9N00_RS02165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9N00_RS02170	COG0107	imidazoleglycerol-phosphate synthase activity
D9N00_RS02185	COG2861	carbohydrate metabolic process
D9N00_RS02190	COG0793	Belongs to the peptidase S41A family
D9N00_RS02195	COG4942	peptidase
D9N00_RS02200	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D9N00_RS02205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9N00_RS02215	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D9N00_RS02220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D9N00_RS02230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9N00_RS02235	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
D9N00_RS02240	COG4521	taurine ABC transporter
D9N00_RS02260	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9N00_RS02305	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9N00_RS02305	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D9N00_RS02310	COG2918	glutathione biosynthetic process
D9N00_RS02320	COG2183	response to ionizing radiation
D9N00_RS02355	COG2204	response regulator
D9N00_RS02360	COG5002	protein histidine kinase activity
D9N00_RS02365	COG4115	mRNA cleavage
D9N00_RS02370	COG2161	toxin-antitoxin pair type II binding
D9N00_RS02375	COG3023	N-Acetylmuramoyl-L-alanine amidase
D9N00_RS02390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9N00_RS02400	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D9N00_RS02425	COG1609	Transcriptional regulator
D9N00_RS02430	COG4771	TonB-dependent receptor
D9N00_RS02435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9N00_RS02440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9N00_RS02445	COG0667	Aldo Keto reductase
D9N00_RS02460	COG3852	Histidine kinase
D9N00_RS02495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9N00_RS02495	COG0301	tRNA thio-modification
D9N00_RS02500	COG1217	gtp-binding protein TYPA
D9N00_RS02505	COG1349	DNA-binding transcription factor activity
D9N00_RS02615	COG0642	Histidine kinase
D9N00_RS02625	COG1422	Protein of unknown function (DUF1090)
D9N00_RS02630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9N00_RS02635	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D9N00_RS02645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9N00_RS02655	COG0126	phosphoglycerate kinase activity
D9N00_RS02705	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS02705	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9N00_RS02710	COG0247	lactate metabolic process
D9N00_RS02710	COG2181	nitrate reductase activity
D9N00_RS02715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D9N00_RS02725	COG3469	chitinase activity
D9N00_RS02735	COG4638	Rieske (2fe-2S)
D9N00_RS02765	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D9N00_RS02795	COG0494	nUDIX hydrolase
D9N00_RS02800	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
D9N00_RS02810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D9N00_RS02815	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D9N00_RS02835	COG0789	Transcriptional regulator
D9N00_RS02850	COG1228	amidohydrolase
D9N00_RS02860	COG2986	histidine ammonia-lyase
D9N00_RS02865	COG2986	histidine ammonia-lyase
D9N00_RS02870	COG4175	Glycine betaine
D9N00_RS02875	COG4176	ABC-type proline glycine betaine transport system permease component
D9N00_RS02890	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D9N00_RS02900	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
D9N00_RS02905	COG0735	belongs to the Fur family
D9N00_RS02910	COG1121	(ABC) transporter
D9N00_RS02915	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9N00_RS02935	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9N00_RS02940	COG2011	ABC-type metal ion transport system permease component
D9N00_RS02945	COG1464	Belongs to the NlpA lipoprotein family
D9N00_RS02965	COG0659	secondary active sulfate transmembrane transporter activity
D9N00_RS02980	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
D9N00_RS02985	COG0586	Pfam SNARE associated Golgi protein
D9N00_RS02995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D9N00_RS03000	COG0248	Ppx GppA phosphatase
D9N00_RS03010	COG1126	abc transporter atp-binding protein
D9N00_RS03015	COG0765	amino acid transport
D9N00_RS03020	COG0765	amino acid transport
D9N00_RS03025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS03030	COG2186	Transcriptional regulator
D9N00_RS03045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D9N00_RS03050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9N00_RS03050	COG0543	2 iron, 2 sulfur cluster binding
D9N00_RS03060	COG2271	Major facilitator Superfamily
D9N00_RS03100	COG4104	PAAR repeat-containing protein
D9N00_RS03125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D9N00_RS03145	COG3079	Belongs to the UPF0149 family
D9N00_RS03150	COG0006	proline dipeptidase activity
D9N00_RS03155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9N00_RS03160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D9N00_RS03170	COG2271	Major facilitator Superfamily
D9N00_RS03205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9N00_RS03210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9N00_RS03225	COG0662	Cupin 2, conserved barrel domain protein
D9N00_RS03260	COG2369	cell adhesion
D9N00_RS03275	COG2175	clavaminate synthase activity
D9N00_RS03320	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9N00_RS03335	COG2011	ABC-type metal ion transport system permease component
D9N00_RS03340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D9N00_RS03375	COG1126	abc transporter atp-binding protein
D9N00_RS03380	COG0765	amino acid transport
D9N00_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS03390	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D9N00_RS03395	COG1045	serine acetyltransferase
D9N00_RS03415	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D9N00_RS03425	COG2188	Transcriptional regulator
D9N00_RS03430	COG0402	S-adenosylhomocysteine deaminase activity
D9N00_RS03440	COG3040	lipid binding
D9N00_RS03450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D9N00_RS03465	COG0058	SHG alpha-glucan phosphorylase activity
D9N00_RS03470	COG0596	Alpha beta hydrolase
D9N00_RS03475	COG1490	D-aminoacyl-tRNA deacylase activity
D9N00_RS03480	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D9N00_RS03485	COG2943	transferase activity, transferring hexosyl groups
D9N00_RS03500	COG0840	transmembrane signaling receptor activity
D9N00_RS03505	COG0840	transmembrane signaling receptor activity
D9N00_RS03520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9N00_RS03525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D9N00_RS03530	COG0140	phosphoribosyl-ATP diphosphatase activity
D9N00_RS03535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9N00_RS03540	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D9N00_RS03550	COG2226	methyltransferase
D9N00_RS03595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9N00_RS03600	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9N00_RS03610	COG0018	arginyl-trna synthetase
D9N00_RS03615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D9N00_RS03620	COG0254	rRNA binding
D9N00_RS03630	COG0281	malic enzyme
D9N00_RS03665	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D9N00_RS03670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9N00_RS03690	COG0069	glutamate synthase activity
D9N00_RS03690	COG0070	glutamate synthase
D9N00_RS03690	COG0067	glutamate synthase
D9N00_RS03695	COG0493	'glutamate synthase
D9N00_RS03700	COG0154	amidase activity
D9N00_RS03715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D9N00_RS03725	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D9N00_RS03750	COG2814	Major facilitator Superfamily
D9N00_RS03755	COG0583	DNA-binding transcription factor activity
D9N00_RS03760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9N00_RS03765	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS03775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9N00_RS03840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9N00_RS03845	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9N00_RS03860	COG1192	Involved in chromosome partitioning
D9N00_RS03880	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
D9N00_RS03885	COG3052	prosthetic group binding
D9N00_RS03905	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9N00_RS03925	COG1272	protein, Hemolysin III
D9N00_RS03935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D9N00_RS03955	COG3038	cytochrome b561
D9N00_RS03960	COG2353	YceI-like domain
D9N00_RS04000	COG0513	Belongs to the DEAD box helicase family
D9N00_RS04005	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9N00_RS04015	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D9N00_RS04030	COG3622	Belongs to the hyi family
D9N00_RS04035	COG2610	gluconate transmembrane transporter activity
D9N00_RS04040	COG0235	Class ii aldolase
D9N00_RS04045	COG3395	kinase activity
D9N00_RS04050	COG2084	Dehydrogenase
D9N00_RS04060	COG0436	Aminotransferase
D9N00_RS04065	COG0129	dihydroxy-acid dehydratase activity
D9N00_RS04095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9N00_RS04100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D9N00_RS04105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9N00_RS04105	COG2813	Specifically methylates the guanine in position
D9N00_RS04110	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9N00_RS04140	COG0791	NLP P60 protein
D9N00_RS04150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D9N00_RS04155	COG0540	Belongs to the ATCase OTCase family
D9N00_RS04160	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D9N00_RS04165	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D9N00_RS04170	COG1678	Uncharacterized ACR, COG1678
D9N00_RS04180	COG0189	ligase activity
D9N00_RS04205	COG2198	Histidine kinase
D9N00_RS04205	COG0643	Histidine kinase
D9N00_RS04205	COG0784	Response regulator, receiver
D9N00_RS04225	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D9N00_RS04230	COG1802	Transcriptional regulator
D9N00_RS04265	COG2433	Pfam Transposase IS66
D9N00_RS04270	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS04295	COG4104	PAAR repeat-containing protein
D9N00_RS04310	COG1196	nuclear chromosome segregation
D9N00_RS04310	COG3264	Mechanosensitive ion channel
D9N00_RS04315	COG3263	regulation of cellular component size
D9N00_RS04330	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS04335	COG0506	proline dehydrogenase activity
D9N00_RS04335	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D9N00_RS04335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D9N00_RS04340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9N00_RS04355	COG1451	nucleotide metabolic process
D9N00_RS04365	COG2153	protein acetylation
D9N00_RS04375	COG1289	transmembrane transporter activity
D9N00_RS04380	COG2081	HI0933 family
D9N00_RS04390	COG0513	Belongs to the DEAD box helicase family
D9N00_RS04410	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D9N00_RS04415	COG0859	PFAM glycosyl transferase family 9
D9N00_RS04425	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS04455	COG2192	nodulation
D9N00_RS04500	COG1132	(ABC) transporter
D9N00_RS04505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D9N00_RS04505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D9N00_RS04515	COG0667	Aldo Keto reductase
D9N00_RS04530	COG1519	Transferase
D9N00_RS04535	COG1538	Outer membrane efflux protein
D9N00_RS04540	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D9N00_RS04560	COG0494	nUDIX hydrolase
D9N00_RS04575	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D9N00_RS04595	COG3577	Aspartyl protease
D9N00_RS04630	COG3830	Belongs to the UPF0237 family
D9N00_RS04630	COG0560	Phosphoserine phosphatase
D9N00_RS04640	COG0688	phosphatidylethanolamine metabolic process
D9N00_RS04660	COG1162	GTPase activity
D9N00_RS04665	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D9N00_RS04670	COG2860	membrane
D9N00_RS04685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D9N00_RS04685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D9N00_RS04690	COG0802	atpase or kinase
D9N00_RS04695	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9N00_RS04700	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D9N00_RS04705	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9N00_RS04710	COG1923	regulation of RNA biosynthetic process
D9N00_RS04715	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D9N00_RS04720	COG0330	HflC and HflK could
D9N00_RS04725	COG0330	HflC and HflK could
D9N00_RS04730	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D9N00_RS04735	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9N00_RS04740	COG0840	transmembrane signaling receptor activity
D9N00_RS04765	COG0557	exoribonuclease II activity
D9N00_RS04770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D9N00_RS04775	COG0360	Binds together with S18 to 16S ribosomal RNA
D9N00_RS04780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D9N00_RS04790	COG0359	binds to the 23S rRNA
D9N00_RS04795	COG0305	Participates in initiation and elongation during chromosome replication
D9N00_RS04800	COG1032	radical SAM domain protein
D9N00_RS04815	COG2308	Evidence 4 Homologs of previously reported genes of
D9N00_RS04815	COG2307	Protein conserved in bacteria
D9N00_RS04835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D9N00_RS04840	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D9N00_RS04845	COG0583	DNA-binding transcription factor activity
D9N00_RS04880	COG4221	oxidoreductase activity
D9N00_RS04895	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D9N00_RS04900	COG0830	nickel cation binding
D9N00_RS04905	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D9N00_RS04915	COG2982	Protein involved in outer membrane biogenesis
D9N00_RS04930	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS04945	COG4372	Transposase
D9N00_RS04990	COG0697	spore germination
D9N00_RS05005	COG0443	Heat shock 70 kDa protein
D9N00_RS05010	COG0484	heat shock protein binding
D9N00_RS05025	COG0804	urea catabolic process
D9N00_RS05030	COG0832	Belongs to the urease beta subunit family
D9N00_RS05045	COG0831	urea catabolic process
D9N00_RS05050	COG0829	nickel cation binding
D9N00_RS05135	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D9N00_RS05145	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9N00_RS05185	COG2095	MarC family integral membrane protein
D9N00_RS05195	COG0151	Belongs to the GarS family
D9N00_RS05200	COG0138	bifunctional purine biosynthesis protein purh
D9N00_RS05210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9N00_RS05220	COG2264	protein methyltransferase activity
D9N00_RS05235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D9N00_RS05275	COG4964	Belongs to the GSP D family
D9N00_RS05295	COG4953	penicillin-binding protein 1C
D9N00_RS05310	COG0534	Mate efflux family protein
D9N00_RS05320	COG1166	arginine decarboxylase activity
D9N00_RS05325	COG0023	Translation Initiation Factor
D9N00_RS05375	COG0586	Pfam SNARE associated Golgi protein
D9N00_RS05380	COG2094	Belongs to the DNA glycosylase MPG family
D9N00_RS05390	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D9N00_RS05395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D9N00_RS05405	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D9N00_RS05410	COG0768	penicillin binding
D9N00_RS05415	COG0772	Belongs to the SEDS family
D9N00_RS05420	COG2951	lytic endotransglycosylase activity
D9N00_RS05435	COG1686	Belongs to the peptidase S11 family
D9N00_RS05440	COG2921	Belongs to the UPF0250 family
D9N00_RS05445	COG0321	lipoyl(octanoyl) transferase activity
D9N00_RS05450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9N00_RS05460	COG2951	lytic endotransglycosylase activity
D9N00_RS05495	COG0495	leucyl-tRNA aminoacylation
D9N00_RS05510	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D9N00_RS05515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D9N00_RS05520	COG4535	Mg2 and Co2 transporter CorC
D9N00_RS05525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9N00_RS05530	COG1702	phosphate starvation-inducible protein PhoH
D9N00_RS05535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9N00_RS05555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D9N00_RS05560	COG0352	thiamine-phosphate diphosphorylase activity
D9N00_RS05575	COG4999	Histidine kinase
D9N00_RS05575	COG3850	Histidine kinase
D9N00_RS05575	COG3437	response regulator, receiver
D9N00_RS05575	COG2205	protein histidine kinase activity
D9N00_RS05580	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D9N00_RS05590	COG1522	sequence-specific DNA binding
D9N00_RS05610	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
D9N00_RS05630	COG2384	SAM-dependent methyltransferase
D9N00_RS05655	COG1643	Atp-dependent helicase
D9N00_RS05660	COG1643	Atp-dependent helicase
D9N00_RS05690	COG1002	Type II restriction enzyme, methylase subunits
D9N00_RS05695	COG1061	Type III restriction enzyme res subunit
D9N00_RS05705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9N00_RS05720	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS05735	COG4372	Transposase
D9N00_RS05755	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS05755	COG1216	Glycosyl transferase, family 2
D9N00_RS05785	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS05795	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS05800	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D9N00_RS05800	COG0662	Cupin 2, conserved barrel domain protein
D9N00_RS05815	COG0012	GTP binding
D9N00_RS05820	COG0193	aminoacyl-tRNA hydrolase activity
D9N00_RS05825	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9N00_RS05830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9N00_RS05840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D9N00_RS05845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
D9N00_RS05855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D9N00_RS05860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D9N00_RS05870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D9N00_RS05875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D9N00_RS05910	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D9N00_RS05920	COG0493	'glutamate synthase
D9N00_RS05925	COG4221	oxidoreductase activity
D9N00_RS05935	COG0415	Belongs to the DNA photolyase family
D9N00_RS05940	COG0789	Transcriptional regulator
D9N00_RS05985	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
D9N00_RS05990	COG1090	epimerase
D9N00_RS05995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D9N00_RS06020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D9N00_RS06025	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
D9N00_RS06040	COG0765	amino acid transport
D9N00_RS06045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS06055	COG0579	oxidoreductase
D9N00_RS06105	COG2135	peptidase activity
D9N00_RS06110	COG0501	Belongs to the peptidase M48B family
D9N00_RS06115	COG2119	membrane
D9N00_RS06120	COG2813	Specifically methylates the guanine in position
D9N00_RS06130	COG1280	lysine exporter protein (LysE YggA)
D9N00_RS06135	COG0318	PFAM AMP-dependent synthetase and ligase
D9N00_RS06165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9N00_RS06170	COG0596	Alpha beta hydrolase
D9N00_RS06175	COG0251	oxidation-reduction process
D9N00_RS06180	COG1335	isochorismatase
D9N00_RS06190	COG1309	transcriptional regulator
D9N00_RS06200	COG3845	ABC transporter
D9N00_RS06210	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS06215	COG2885	chlorophyll binding
D9N00_RS06220	COG0204	Acyl-transferase
D9N00_RS06225	COG0857	belongs to the CobB CobQ family
D9N00_RS06225	COG0280	phosphate acetyltransferase
D9N00_RS06235	COG1047	Peptidyl-prolyl cis-trans
D9N00_RS06240	COG0386	Belongs to the glutathione peroxidase family
D9N00_RS06285	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
D9N00_RS06290	COG0492	ferredoxin-NADP+ reductase activity
D9N00_RS06310	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9N00_RS06315	COG0302	gtp cyclohydrolase
D9N00_RS06340	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS06365	COG1215	transferase activity, transferring glycosyl groups
D9N00_RS06375	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D9N00_RS06425	COG4774	siderophore transport
D9N00_RS06435	COG4772	TonB-dependent receptor
D9N00_RS06445	COG3712	iron ion homeostasis
D9N00_RS06470	COG2207	Transcriptional regulator
D9N00_RS06470	COG1917	Cupin 2, conserved barrel domain protein
D9N00_RS06475	COG0697	spore germination
D9N00_RS06500	COG0583	DNA-binding transcription factor activity
D9N00_RS06525	COG1566	PFAM secretion protein HlyD family protein
D9N00_RS06555	COG0300	oxidoreductase activity
D9N00_RS06565	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D9N00_RS06565	COG0662	Cupin 2, conserved barrel domain protein
D9N00_RS06580	COG1696	Membrane protein involved in D-alanine export
D9N00_RS06595	COG3420	alginic acid biosynthetic process
D9N00_RS06605	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
D9N00_RS06610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS06615	COG1215	transferase activity, transferring glycosyl groups
D9N00_RS06620	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D9N00_RS06625	COG3022	response to hydroperoxide
D9N00_RS06635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D9N00_RS06640	COG0315	cyclic pyranopterin monophosphate synthase activity
D9N00_RS06645	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D9N00_RS06655	COG0513	Belongs to the DEAD box helicase family
D9N00_RS06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS06670	COG4597	amino acid ABC transporter
D9N00_RS06675	COG0765	amino acid transport
D9N00_RS06680	COG1126	abc transporter atp-binding protein
D9N00_RS06690	COG2807	transmembrane transport
D9N00_RS06715	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D9N00_RS06720	COG3081	Nucleoid-associated protein
D9N00_RS06740	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
D9N00_RS06745	COG0525	valine-tRNA ligase activity
D9N00_RS06765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D9N00_RS06770	COG0795	lipopolysaccharide-transporting ATPase activity
D9N00_RS06775	COG0795	lipopolysaccharide-transporting ATPase activity
D9N00_RS06780	COG1278	Cold shock
D9N00_RS06785	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9N00_RS06790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9N00_RS06790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D9N00_RS06795	COG0509	glycine decarboxylation via glycine cleavage system
D9N00_RS06855	COG0784	Response regulator, receiver
D9N00_RS06860	COG2202	Pas domain
D9N00_RS06860	COG2205	protein histidine kinase activity
D9N00_RS06880	COG2832	Protein of unknown function (DUF454)
D9N00_RS06890	COG4771	TonB-dependent receptor
D9N00_RS06930	COG1653	transport
D9N00_RS06935	COG1175	transmembrane transport
D9N00_RS06945	COG3842	ATPase activity
D9N00_RS06960	COG0676	glucose-6-phosphate 1-epimerase activity
D9N00_RS06965	COG1737	Transcriptional regulator
D9N00_RS06980	COG0800	Aldolase
D9N00_RS06985	COG3530	Putative quorum-sensing-regulated virulence factor
D9N00_RS06995	COG3706	GGDEF domain
D9N00_RS06995	COG4251	negative regulation of phosphorylation
D9N00_RS06995	COG5001	Diguanylate cyclase
D9N00_RS06995	COG2203	Gaf domain
D9N00_RS07000	COG5002	protein histidine kinase activity
D9N00_RS07030	COG3121	Chaperone
D9N00_RS07035	COG3188	usher protein
D9N00_RS07040	COG3121	Chaperone
D9N00_RS07070	COG0835	chemotaxis
D9N00_RS07070	COG0784	Response regulator, receiver
D9N00_RS07075	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D9N00_RS07090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9N00_RS07095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9N00_RS07100	COG1845	cytochrome c oxidase, subunit III
D9N00_RS07110	COG0109	protoheme IX farnesyltransferase activity
D9N00_RS07115	COG1216	Glycosyl transferase, family 2
D9N00_RS07125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS07145	COG0640	Transcriptional regulator
D9N00_RS07150	COG0604	alcohol dehydrogenase
D9N00_RS07150	COG3321	synthase
D9N00_RS07150	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS07195	COG3386	PFAM SMP-30 Gluconolaconase
D9N00_RS07220	COG3920	Histidine kinase
D9N00_RS07225	COG1802	Transcriptional regulator
D9N00_RS07240	COG3845	ABC transporter
D9N00_RS07245	COG1335	isochorismatase
D9N00_RS07255	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS07260	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS07280	COG2814	Major facilitator Superfamily
D9N00_RS07305	COG5645	(Lipo)protein
D9N00_RS07320	COG3781	membrane
D9N00_RS07360	COG0741	lytic transglycosylase activity
D9N00_RS07360	COG1388	LysM domain
D9N00_RS07390	COG4669	(LipO)protein
D9N00_RS07445	COG4792	protein secretion
D9N00_RS07455	COG4794	Type iii secretion
D9N00_RS07465	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9N00_RS07470	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9N00_RS07485	COG1157	protein secretion by the type III secretion system
D9N00_RS07545	COG0582	viral genome integration into host DNA
D9N00_RS07555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D9N00_RS07560	COG0343	queuine tRNA-ribosyltransferase activity
D9N00_RS07565	COG1862	Preprotein translocase
D9N00_RS07580	COG3134	Outer membrane lipoprotein
D9N00_RS07595	COG1045	serine acetyltransferase
D9N00_RS07610	COG1104	cysteine desulfurase activity
D9N00_RS07620	COG0316	Belongs to the HesB IscA family
D9N00_RS07625	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9N00_RS07630	COG0443	Heat shock 70 kDa protein
D9N00_RS07635	COG0633	Ferredoxin
D9N00_RS07645	COG0105	UTP biosynthetic process
D9N00_RS07650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9N00_RS07665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D9N00_RS07670	COG0124	histidyl-tRNA synthetase
D9N00_RS07685	COG1160	GTP binding
D9N00_RS07690	COG0436	Aminotransferase
D9N00_RS07695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9N00_RS07705	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D9N00_RS07710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9N00_RS07720	COG0739	heme binding
D9N00_RS07725	COG1570	exodeoxyribonuclease VII activity
D9N00_RS07745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9N00_RS07745	COG0519	Catalyzes the synthesis of GMP from XMP
D9N00_RS07770	COG3604	Transcriptional regulator
D9N00_RS07795	COG2132	Multicopper oxidase
D9N00_RS07800	COG0590	tRNA wobble adenosine to inosine editing
D9N00_RS07805	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
D9N00_RS07810	COG0047	phosphoribosylformylglycinamidine synthase activity
D9N00_RS07810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D9N00_RS07835	COG0494	nUDIX hydrolase
D9N00_RS07870	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D9N00_RS07875	COG0477	Major facilitator Superfamily
D9N00_RS07880	COG4536	flavin adenine dinucleotide binding
D9N00_RS07890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9N00_RS07895	COG0228	four-way junction DNA binding
D9N00_RS07900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9N00_RS07905	COG0336	Belongs to the RNA methyltransferase TrmD family
D9N00_RS07910	COG0335	large ribosomal subunit rRNA binding
D9N00_RS07915	COG4974	Belongs to the 'phage' integrase family
D9N00_RS07925	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D9N00_RS07945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS07945	COG2205	protein histidine kinase activity
D9N00_RS07980	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS08010	COG0457	Tetratricopeptide repeat
D9N00_RS08010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9N00_RS08015	COG0835	chemotaxis
D9N00_RS08025	COG2201	protein-glutamate methylesterase activity
D9N00_RS08030	COG5001	Diguanylate cyclase
D9N00_RS08030	COG2203	Gaf domain
D9N00_RS08030	COG3706	GGDEF domain
D9N00_RS08030	COG4251	negative regulation of phosphorylation
D9N00_RS08040	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9N00_RS08055	COG1073	alpha beta
D9N00_RS08065	COG3047	cAMP biosynthetic process
D9N00_RS08065	COG2885	chlorophyll binding
D9N00_RS08075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D9N00_RS08080	COG0563	adenylate kinase activity
D9N00_RS08110	COG0742	ribosomal rna small subunit methyltransferase
D9N00_RS08140	COG2937	Belongs to the GPAT DAPAT family
D9N00_RS08150	COG2226	methyltransferase
D9N00_RS08155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9N00_RS08160	COG1215	transferase activity, transferring glycosyl groups
D9N00_RS08165	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D9N00_RS08175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D9N00_RS08180	COG2171	N-acyltransferase activity
D9N00_RS08185	COG1393	Belongs to the ArsC family
D9N00_RS08200	COG0436	Aminotransferase
D9N00_RS08205	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D9N00_RS08210	COG0024	Methionine aminopeptidase
D9N00_RS08215	COG0052	Belongs to the universal ribosomal protein uS2 family
D9N00_RS08220	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D9N00_RS08225	COG0528	UMP kinase activity
D9N00_RS08230	COG0233	cytoplasmic translational termination
D9N00_RS08235	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D9N00_RS08245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D9N00_RS08265	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9N00_RS08270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9N00_RS08275	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9N00_RS08280	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9N00_RS08285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D9N00_RS08290	COG0587	DNA-directed DNA polymerase activity
D9N00_RS08295	COG0825	malonyl-CoA metabolic process
D9N00_RS08300	COG0037	tRNA processing
D9N00_RS08305	COG0504	CTP synthase activity
D9N00_RS08310	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D9N00_RS08315	COG0148	phosphopyruvate hydratase activity
D9N00_RS08325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D9N00_RS08335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D9N00_RS08340	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D9N00_RS08345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D9N00_RS08350	COG0585	pseudouridine synthase activity
D9N00_RS08355	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D9N00_RS08360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D9N00_RS08375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D9N00_RS08380	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D9N00_RS08385	COG1546	Belongs to the CinA family
D9N00_RS08390	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D9N00_RS08395	COG2137	regulation of response to DNA damage stimulus
D9N00_RS08410	COG3148	PFAM DTW domain containing protein
D9N00_RS08430	COG0583	DNA-binding transcription factor activity
D9N00_RS08445	COG4807	Protein conserved in bacteria
D9N00_RS08450	COG1187	pseudouridine synthase activity
D9N00_RS08455	COG0519	Catalyzes the synthesis of GMP from XMP
D9N00_RS08460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9N00_RS08485	COG3158	transport of potassium into the cell
D9N00_RS08510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS08520	COG0442	prolyl-tRNA aminoacylation
D9N00_RS08535	COG2900	Belongs to the SlyX family
D9N00_RS08550	COG0783	Belongs to the Dps family
D9N00_RS08560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D9N00_RS08565	COG0217	transcriptional regulatory protein
D9N00_RS08570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D9N00_RS08575	COG0632	four-way junction helicase activity
D9N00_RS08580	COG2255	four-way junction helicase activity
D9N00_RS08585	COG0824	Thioesterase
D9N00_RS08605	COG0823	Involved in the tonB-independent uptake of proteins
D9N00_RS08610	COG2885	chlorophyll binding
D9N00_RS08615	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
D9N00_RS08620	COG0602	queuosine metabolic process
D9N00_RS08625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D9N00_RS08645	COG2135	peptidase activity
D9N00_RS08655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS08870	COG4974	Belongs to the 'phage' integrase family
D9N00_RS08890	COG0583	DNA-binding transcription factor activity
D9N00_RS08905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9N00_RS08910	COG0148	phosphopyruvate hydratase activity
D9N00_RS08935	COG0038	chloride channel
D9N00_RS08950	COG0789	Transcriptional regulator
D9N00_RS08970	COG4974	Belongs to the 'phage' integrase family
D9N00_RS09015	COG1247	-acetyltransferase
D9N00_RS09020	COG0431	NADPH-dependent FMN reductase
D9N00_RS09030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9N00_RS09035	COG0640	Transcriptional regulator
D9N00_RS09045	COG1230	cation diffusion facilitator family transporter
D9N00_RS09055	COG4974	Belongs to the 'phage' integrase family
D9N00_RS09070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9N00_RS09110	COG0653	protein targeting
D9N00_RS09115	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9N00_RS09185	COG0305	Participates in initiation and elongation during chromosome replication
D9N00_RS09200	COG2894	cell division
D9N00_RS09230	COG2135	peptidase activity
D9N00_RS09500	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS09515	COG2433	Pfam Transposase IS66
D9N00_RS09535	COG4774	siderophore transport
D9N00_RS09565	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D9N00_RS09575	COG0425	Belongs to the sulfur carrier protein TusA family
D9N00_RS09585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D9N00_RS09595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9N00_RS09600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
D9N00_RS09605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9N00_RS09610	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D9N00_RS09660	COG0281	malic enzyme
D9N00_RS09665	COG2194	sulfuric ester hydrolase activity
D9N00_RS09675	COG3100	YcgL domain-containing protein
D9N00_RS09690	COG2983	Belongs to the UPF0260 family
D9N00_RS09705	COG3667	copper resistance
D9N00_RS09710	COG2132	Multicopper oxidase
D9N00_RS09725	COG1770	oligopeptidase
D9N00_RS09735	COG0121	glutamine amidotransferase
D9N00_RS09755	COG0542	response to heat
D9N00_RS09775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D9N00_RS09795	COG3328	transposase activity
D9N00_RS09830	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D9N00_RS09840	COG0745	RESPONSE REGULATOR receiver
D9N00_RS09850	COG2205	protein histidine kinase activity
D9N00_RS09900	COG1301	dicarboxylic acid transport
D9N00_RS09905	COG3091	SprT-like family
D9N00_RS09910	COG0037	tRNA processing
D9N00_RS09915	COG2818	Glycosylase
D9N00_RS09925	COG1393	Belongs to the ArsC family
D9N00_RS09930	COG3118	belongs to the thioredoxin family
D9N00_RS09955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9N00_RS09960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9N00_RS09965	COG3956	TIGRFAM MazG family protein
D9N00_RS09990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D9N00_RS09995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D9N00_RS10010	COG0628	permease
D9N00_RS10020	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9N00_RS10025	COG0791	NLP P60 protein
D9N00_RS10025	COG1388	LysM domain
D9N00_RS10030	COG0791	NLP P60 protein
D9N00_RS10050	COG1797	cobyrinic acid a,c-diamide synthase activity
D9N00_RS10055	COG0778	Nitroreductase
D9N00_RS10070	COG1492	cobalamin metabolic process
D9N00_RS10080	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D9N00_RS10090	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D9N00_RS10165	COG0697	spore germination
D9N00_RS10175	COG0114	fumarate hydratase activity
D9N00_RS10185	COG0271	Belongs to the BolA IbaG family
D9N00_RS10190	COG1054	Belongs to the UPF0176 family
D9N00_RS10205	COG5002	protein histidine kinase activity
D9N00_RS10205	COG5001	Diguanylate cyclase
D9N00_RS10220	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS10225	COG0546	phosphoglycolate phosphatase activity
D9N00_RS10230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9N00_RS10235	COG0402	S-adenosylhomocysteine deaminase activity
D9N00_RS10240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D9N00_RS10250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D9N00_RS10260	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9N00_RS10265	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D9N00_RS10275	COG0776	regulation of translation
D9N00_RS10285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9N00_RS10295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9N00_RS10305	COG1555	photosystem II stabilization
D9N00_RS10315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D9N00_RS10325	COG0814	amino acid
D9N00_RS10350	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9N00_RS10355	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9N00_RS10365	COG3328	transposase activity
D9N00_RS10375	COG1764	response to oxidative stress
D9N00_RS10380	COG1846	Transcriptional regulator
D9N00_RS10390	COG0583	DNA-binding transcription factor activity
D9N00_RS10395	COG5457	Domain of unknown function (DUF1127)
D9N00_RS10400	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D9N00_RS10425	COG3384	dioxygenase
D9N00_RS10430	COG0500	methyltransferase
D9N00_RS10435	COG0501	Belongs to the peptidase M48B family
D9N00_RS10440	COG0436	Aminotransferase
D9N00_RS10445	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D9N00_RS10450	COG0386	Belongs to the glutathione peroxidase family
D9N00_RS10465	COG1956	GAF domain-containing protein
D9N00_RS10510	COG1741	Belongs to the pirin family
D9N00_RS10515	COG0583	DNA-binding transcription factor activity
D9N00_RS10520	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS10525	COG2358	TRAP transporter, solute receptor (TAXI family
D9N00_RS10545	COG0583	DNA-binding transcription factor activity
D9N00_RS10555	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9N00_RS10560	COG1116	anion transmembrane transporter activity
D9N00_RS10590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D9N00_RS10600	COG0642	Histidine kinase
D9N00_RS10615	COG0745	RESPONSE REGULATOR receiver
D9N00_RS10625	COG2350	Protein conserved in bacteria
D9N00_RS10630	COG2917	probably involved in intracellular septation
D9N00_RS10635	COG0613	PHP domain protein
D9N00_RS10640	COG0009	L-threonylcarbamoyladenylate synthase
D9N00_RS10650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D9N00_RS10690	COG2154	pterin-4-alpha-carbinolamine dehydratase
D9N00_RS10710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D9N00_RS10715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS10750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9N00_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS10770	COG3724	N-succinylarginine dihydrolase activity
D9N00_RS10780	COG2988	succinylglutamate desuccinylase activity
D9N00_RS10790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9N00_RS10795	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
D9N00_RS10800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9N00_RS10805	COG0527	aspartate kinase activity
D9N00_RS10810	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9N00_RS10835	COG2239	Acts as a magnesium transporter
D9N00_RS10880	COG1484	DNA-dependent DNA replication
D9N00_RS10885	COG0596	Alpha beta hydrolase
D9N00_RS10895	COG4191	Histidine kinase
D9N00_RS10895	COG0784	Response regulator, receiver
D9N00_RS10900	COG1953	Uracil, thiamine, allantoin
D9N00_RS10930	COG1063	alcohol dehydrogenase
D9N00_RS10935	COG0583	DNA-binding transcription factor activity
D9N00_RS10945	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS10950	COG1473	amidohydrolase
D9N00_RS10965	COG0583	DNA-binding transcription factor activity
D9N00_RS10980	COG1760	l-serine dehydratase
D9N00_RS10985	COG0583	DNA-binding transcription factor activity
D9N00_RS11000	COG5383	Protein conserved in bacteria
D9N00_RS11005	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS11015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS11020	COG0642	Histidine kinase
D9N00_RS11065	COG4251	negative regulation of phosphorylation
D9N00_RS11090	COG2271	Major facilitator Superfamily
D9N00_RS11115	COG1611	Belongs to the LOG family
D9N00_RS11120	COG4991	sh3 domain protein
D9N00_RS11140	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS11150	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9N00_RS11155	COG2814	Major facilitator Superfamily
D9N00_RS11180	COG0477	Major facilitator Superfamily
D9N00_RS11185	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D9N00_RS11205	COG0784	Response regulator, receiver
D9N00_RS11205	COG0835	chemotaxis
D9N00_RS11210	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9N00_RS11215	COG0583	DNA-binding transcription factor activity
D9N00_RS11220	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D9N00_RS11270	COG1815	bacterial-type flagellum-dependent cell motility
D9N00_RS11280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D9N00_RS11285	COG1749	Flagellar hook protein flgE
D9N00_RS11300	COG4787	bacterial-type flagellum-dependent cell motility
D9N00_RS11310	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D9N00_RS11315	COG1706	bacterial-type flagellum-dependent cell motility
D9N00_RS11335	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS11335	COG1216	Glycosyl transferase, family 2
D9N00_RS11340	COG1216	Glycosyl transferase, family 2
D9N00_RS11340	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS11345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D9N00_RS11360	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D9N00_RS11390	COG1677	Flagellar hook-basal body complex protein FliE
D9N00_RS11425	COG0745	RESPONSE REGULATOR receiver
D9N00_RS11485	COG1987	bacterial-type flagellum assembly
D9N00_RS11495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9N00_RS11505	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9N00_RS11530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
D9N00_RS11535	COG2198	Histidine kinase
D9N00_RS11535	COG0784	Response regulator, receiver
D9N00_RS11535	COG0643	Histidine kinase
D9N00_RS11540	COG2201	protein-glutamate methylesterase activity
D9N00_RS11545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D9N00_RS11555	COG1192	Involved in chromosome partitioning
D9N00_RS11565	COG0835	chemotaxis
D9N00_RS11580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9N00_RS11585	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9N00_RS11610	COG2217	Heavy metal translocating P-type atpase
D9N00_RS11635	COG2010	Cytochrome c
D9N00_RS11650	COG3278	Belongs to the heme-copper respiratory oxidase family
D9N00_RS11700	COG0840	transmembrane signaling receptor activity
D9N00_RS11710	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
D9N00_RS11715	COG0425	Belongs to the sulfur carrier protein TusA family
D9N00_RS11720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9N00_RS11730	COG1132	(ABC) transporter
D9N00_RS11735	COG3123	guanosine phosphorylase activity
D9N00_RS11765	COG0284	orotidine-5'-phosphate decarboxylase activity
D9N00_RS11775	COG2130	NADP-dependent
D9N00_RS11780	COG1619	proteins homologs of microcin C7 resistance protein MccF
D9N00_RS11785	COG3135	benzoate transporter
D9N00_RS11795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9N00_RS11800	COG0625	glutathione transferase activity
D9N00_RS11815	COG0302	gtp cyclohydrolase
D9N00_RS11830	COG2840	Smr protein MutS2
D9N00_RS11860	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D9N00_RS11870	COG0235	Class ii aldolase
D9N00_RS11875	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D9N00_RS11880	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D9N00_RS11885	COG2197	response regulator
D9N00_RS11920	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D9N00_RS11925	COG1368	sulfuric ester hydrolase activity
D9N00_RS11940	COG2308	Evidence 4 Homologs of previously reported genes of
D9N00_RS11950	COG1305	Transglutaminase-like
D9N00_RS11960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D9N00_RS11960	COG0519	Catalyzes the synthesis of GMP from XMP
D9N00_RS11965	COG0598	Magnesium transport protein CorA
D9N00_RS12040	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS12045	COG1335	isochorismatase
D9N00_RS12050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9N00_RS12060	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9N00_RS12080	COG1477	protein flavinylation
D9N00_RS12085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9N00_RS12090	COG0584	glycerophosphoryl diester phosphodiesterase
D9N00_RS12100	COG4591	ABC-type transport system involved in lipoprotein release permease component
D9N00_RS12105	COG1136	(ABC) transporter
D9N00_RS12110	COG4591	ABC-type transport system involved in lipoprotein release permease component
D9N00_RS12115	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9N00_RS12115	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D9N00_RS12145	COG2204	response regulator
D9N00_RS12155	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D9N00_RS12175	COG5002	protein histidine kinase activity
D9N00_RS12235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9N00_RS12240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D9N00_RS12255	COG2205	protein histidine kinase activity
D9N00_RS12255	COG0784	Response regulator, receiver
D9N00_RS12305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D9N00_RS12310	COG1121	(ABC) transporter
D9N00_RS12355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9N00_RS12360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9N00_RS12390	COG2822	iron ion transport
D9N00_RS12395	COG2837	iron assimilation
D9N00_RS12400	COG2822	iron ion transport
D9N00_RS12405	COG0672	)-iron permease
D9N00_RS12410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D9N00_RS12410	COG2169	Transcriptional regulator
D9N00_RS12420	COG0659	secondary active sulfate transmembrane transporter activity
D9N00_RS12425	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9N00_RS12435	COG2223	nitrite transmembrane transporter activity
D9N00_RS12450	COG0583	DNA-binding transcription factor activity
D9N00_RS12470	COG4191	Histidine kinase
D9N00_RS12470	COG0784	Response regulator, receiver
D9N00_RS12520	COG4774	siderophore transport
D9N00_RS12525	COG0456	acetyltransferase
D9N00_RS12560	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9N00_RS12575	COG3265	gluconokinase activity
D9N00_RS12580	COG1609	Transcriptional regulator
D9N00_RS12595	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D9N00_RS12605	COG0247	lactate metabolic process
D9N00_RS12625	COG1129	ABC transporter
D9N00_RS12630	COG4211	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS12665	COG1320	monovalent cation:proton antiporter activity
D9N00_RS12670	COG2212	antiporter activity
D9N00_RS12680	COG0651	ATP synthesis coupled electron transport
D9N00_RS12685	COG1006	Multisubunit Na H antiporter MnhC subunit
D9N00_RS12690	COG2111	Na H antiporter
D9N00_RS12690	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9N00_RS12715	COG3829	transcription factor binding
D9N00_RS12720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9N00_RS12725	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D9N00_RS12735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9N00_RS12745	COG0584	glycerophosphoryl diester phosphodiesterase
D9N00_RS12750	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D9N00_RS12755	COG0504	CTP synthase activity
D9N00_RS12760	COG2329	Antibiotic biosynthesis monooxygenase
D9N00_RS12765	COG2031	fatty acid transporter
D9N00_RS12790	COG0583	DNA-binding transcription factor activity
D9N00_RS12805	COG0431	NADPH-dependent FMN reductase
D9N00_RS12820	COG0438	transferase activity, transferring glycosyl groups
D9N00_RS12855	COG1215	transferase activity, transferring glycosyl groups
D9N00_RS12925	COG0720	synthase
D9N00_RS12960	COG0628	permease
D9N00_RS12980	COG0713	ATP synthesis coupled electron transport
D9N00_RS12990	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9N00_RS12995	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9N00_RS13000	COG1034	ATP synthesis coupled electron transport
D9N00_RS13015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9N00_RS13015	COG0649	NAD binding
D9N00_RS13020	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9N00_RS13025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9N00_RS13040	COG2153	protein acetylation
D9N00_RS13045	COG2850	peptidyl-arginine hydroxylation
D9N00_RS13055	COG2915	High frequency lysogenization protein hflD homolog
D9N00_RS13060	COG0482	sulfurtransferase activity
D9N00_RS13075	COG1278	Cold shock
D9N00_RS13080	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D9N00_RS13085	COG0542	response to heat
D9N00_RS13090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9N00_RS13095	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D9N00_RS13100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D9N00_RS13110	COG1674	ftsk spoiiie
D9N00_RS13115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D9N00_RS13120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D9N00_RS13125	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D9N00_RS13130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D9N00_RS13135	COG1648	precorrin-2 dehydrogenase activity
D9N00_RS13135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9N00_RS13140	COG0435	Glutathione S-transferase
D9N00_RS13145	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9N00_RS13180	COG0583	DNA-binding transcription factor activity
D9N00_RS13185	COG1111	helicase
D9N00_RS13185	COG1205	dead DEAH box helicase
D9N00_RS13210	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
D9N00_RS13265	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS13270	COG0583	DNA-binding transcription factor activity
D9N00_RS13285	COG1309	transcriptional regulator
D9N00_RS13290	COG1472	Belongs to the glycosyl hydrolase 3 family
D9N00_RS13300	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D9N00_RS13305	COG1459	type II secretion system
D9N00_RS13310	COG2165	general secretion pathway protein
D9N00_RS13315	COG2165	general secretion pathway protein
D9N00_RS13330	COG3156	type II secretion system protein K
D9N00_RS13350	COG1450	Type ii and iii secretion system protein
D9N00_RS13365	COG2814	Major facilitator Superfamily
D9N00_RS13375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9N00_RS13380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS13390	COG2267	carboxylic ester hydrolase activity
D9N00_RS13395	COG5002	protein histidine kinase activity
D9N00_RS13400	COG0745	RESPONSE REGULATOR receiver
D9N00_RS13405	COG2116	formate transmembrane transporter activity
D9N00_RS13435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9N00_RS13465	COG3835	regulator
D9N00_RS13470	COG1929	Belongs to the glycerate kinase type-1 family
D9N00_RS13480	COG2942	2-epimerase
D9N00_RS13485	COG3180	Ammonia monooxygenase
D9N00_RS13490	COG0583	DNA-binding transcription factor activity
D9N00_RS13540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D9N00_RS13545	COG0573	inorganic phosphate transmembrane transporter activity
D9N00_RS13550	COG0581	inorganic phosphate transmembrane transporter activity
D9N00_RS13555	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9N00_RS13570	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9N00_RS13570	COG2146	nitrite reductase [NAD(P)H] activity
D9N00_RS13575	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9N00_RS13575	COG2146	nitrite reductase [NAD(P)H] activity
D9N00_RS13605	COG0826	peptidase U32
D9N00_RS13610	COG1120	ATPase activity
D9N00_RS13615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS13625	COG1609	Transcriptional regulator
D9N00_RS13630	COG2186	Transcriptional regulator
D9N00_RS13645	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS13650	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS13655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS13660	COG0601	transmembrane transport
D9N00_RS13665	COG4166	transmembrane transport
D9N00_RS13670	COG4948	Mandelate Racemase Muconate Lactonizing
D9N00_RS13685	COG0406	alpha-ribazole phosphatase activity
D9N00_RS13690	COG0745	RESPONSE REGULATOR receiver
D9N00_RS13700	COG3447	MASE1 domain protein
D9N00_RS13700	COG5001	Diguanylate cyclase
D9N00_RS13700	COG5002	protein histidine kinase activity
D9N00_RS13750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9N00_RS13755	COG0659	secondary active sulfate transmembrane transporter activity
D9N00_RS13770	COG0583	DNA-binding transcription factor activity
D9N00_RS13780	COG3210	domain, Protein
D9N00_RS13790	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS13825	COG3328	transposase activity
D9N00_RS13830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D9N00_RS13835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9N00_RS13835	COG0473	3-isopropylmalate dehydrogenase activity
D9N00_RS13840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9N00_RS13850	COG2070	2-Nitropropane dioxygenase
D9N00_RS13865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9N00_RS13875	COG2814	Major facilitator Superfamily
D9N00_RS13880	COG0583	DNA-binding transcription factor activity
D9N00_RS13895	COG0154	amidase activity
D9N00_RS13900	COG1349	DNA-binding transcription factor activity
D9N00_RS13905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9N00_RS13930	COG0583	DNA-binding transcription factor activity
D9N00_RS13935	COG0667	Aldo Keto reductase
D9N00_RS13940	COG1741	Belongs to the pirin family
D9N00_RS13945	COG0583	DNA-binding transcription factor activity
D9N00_RS13960	COG3008	intermembrane lipid transfer
D9N00_RS13965	COG2995	paraquat-inducible protein a
D9N00_RS13970	COG2995	paraquat-inducible protein a
D9N00_RS14035	COG0183	Belongs to the thiolase family
D9N00_RS14040	COG1024	Enoyl-CoA hydratase
D9N00_RS14045	COG0217	transcriptional regulatory protein
D9N00_RS14070	COG2866	Carboxypeptidase
D9N00_RS14080	COG1522	sequence-specific DNA binding
D9N00_RS14150	COG4638	Rieske (2fe-2S)
D9N00_RS14155	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
D9N00_RS14160	COG0543	2 iron, 2 sulfur cluster binding
D9N00_RS14160	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9N00_RS14165	COG4948	Mandelate Racemase Muconate Lactonizing
D9N00_RS14170	COG4829	muconolactone delta-isomerase
D9N00_RS14175	COG3485	protocatechuate 3,4-dioxygenase
D9N00_RS14200	COG1289	transmembrane transporter activity
D9N00_RS14235	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
D9N00_RS14240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9N00_RS14290	COG1538	Outer membrane efflux protein
D9N00_RS14295	COG0577	efflux transmembrane transporter activity
D9N00_RS14295	COG1136	(ABC) transporter
D9N00_RS14300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS14305	COG2366	antibiotic biosynthetic process
D9N00_RS14320	COG0556	nucleotide-excision repair
D9N00_RS14335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9N00_RS14375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D9N00_RS14395	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D9N00_RS14400	COG0066	3-isopropylmalate dehydratase activity
D9N00_RS14405	COG0473	3-isopropylmalate dehydrogenase activity
D9N00_RS14415	COG3734	2-keto-3-deoxy-galactonokinase
D9N00_RS14420	COG0800	Aldolase
D9N00_RS14425	COG4948	Mandelate Racemase Muconate Lactonizing
D9N00_RS14435	COG2271	Major facilitator Superfamily
D9N00_RS14440	COG1414	Transcriptional regulator
D9N00_RS14445	COG1064	alcohol dehydrogenase
D9N00_RS14450	COG1064	alcohol dehydrogenase
D9N00_RS14470	COG1484	DNA-dependent DNA replication
D9N00_RS14540	COG2207	Transcriptional regulator
D9N00_RS14575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9N00_RS14600	COG2009	succinate dehydrogenase
D9N00_RS14605	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
D9N00_RS14610	COG1053	succinate dehydrogenase
D9N00_RS14615	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D9N00_RS14630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9N00_RS14635	COG0045	succinate-CoA ligase (ADP-forming) activity
D9N00_RS14715	COG1968	undecaprenyl-diphosphatase activity
D9N00_RS14730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9N00_RS14735	COG0583	DNA-binding transcription factor activity
D9N00_RS14740	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9N00_RS14790	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9N00_RS14795	COG0297	glycogen (starch) synthase activity
D9N00_RS14810	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D9N00_RS14815	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9N00_RS14820	COG0561	phosphatase activity
D9N00_RS14825	COG3387	PFAM Glycoside hydrolase 15-related
D9N00_RS14870	COG0784	Response regulator, receiver
D9N00_RS14870	COG4191	Histidine kinase
D9N00_RS14890	COG3634	alkyl hydroperoxide reductase activity
D9N00_RS14935	COG1126	abc transporter atp-binding protein
D9N00_RS14940	COG0765	amino acid transport
D9N00_RS14945	COG0765	amino acid transport
D9N00_RS15070	COG2197	response regulator
D9N00_RS15075	COG2205	protein histidine kinase activity
D9N00_RS15075	COG0784	Response regulator, receiver
D9N00_RS15075	COG2198	Histidine kinase
D9N00_RS15100	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9N00_RS15110	COG0583	DNA-binding transcription factor activity
D9N00_RS15115	COG3485	protocatechuate 3,4-dioxygenase
D9N00_RS15120	COG3485	protocatechuate 3,4-dioxygenase
D9N00_RS15135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9N00_RS15155	COG2271	Major facilitator Superfamily
D9N00_RS15160	COG1082	Xylose isomerase domain protein TIM barrel
D9N00_RS15160	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D9N00_RS15165	COG1309	transcriptional regulator
D9N00_RS15170	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9N00_RS15175	COG0564	pseudouridine synthase activity
D9N00_RS15185	COG0746	molybdenum cofactor guanylyltransferase activity
D9N00_RS15190	COG0521	Mo-molybdopterin cofactor biosynthetic process
D9N00_RS15240	COG0024	Methionine aminopeptidase
D9N00_RS15270	COG1129	ABC transporter
D9N00_RS15275	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS15280	COG1609	Transcriptional regulator
D9N00_RS15285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9N00_RS15290	COG1869	D-ribose catabolic process
D9N00_RS15315	COG0488	(ABC) transporter
D9N00_RS15370	COG0765	amino acid transport
D9N00_RS15375	COG0765	amino acid transport
D9N00_RS15380	COG1126	abc transporter atp-binding protein
D9N00_RS15400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9N00_RS15405	COG0210	DNA helicase
D9N00_RS15420	COG1116	anion transmembrane transporter activity
D9N00_RS15425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D9N00_RS15445	COG0667	Aldo Keto reductase
D9N00_RS15465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9N00_RS15480	COG0587	DNA-directed DNA polymerase activity
D9N00_RS15490	COG0598	Magnesium transport protein CorA
D9N00_RS15510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D9N00_RS15520	COG0583	DNA-binding transcription factor activity
D9N00_RS15525	COG0583	DNA-binding transcription factor activity
D9N00_RS15530	COG0277	FAD linked oxidase domain protein
D9N00_RS15530	COG0247	lactate metabolic process
D9N00_RS15540	COG3706	GGDEF domain
D9N00_RS15550	COG2072	flavoprotein involved in K transport
D9N00_RS15555	COG0601	transmembrane transport
D9N00_RS15565	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS15570	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS15575	COG0747	negative chemotaxis
D9N00_RS15685	COG0210	DNA helicase
D9N00_RS15710	COG1484	DNA-dependent DNA replication
D9N00_RS15720	COG1196	nuclear chromosome segregation
D9N00_RS15735	COG1396	sequence-specific DNA binding
D9N00_RS15855	COG0583	DNA-binding transcription factor activity
D9N00_RS15865	COG0596	Alpha beta hydrolase
D9N00_RS15905	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS16030	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9N00_RS16045	COG1129	ABC transporter
D9N00_RS16065	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D9N00_RS16080	COG2207	Transcriptional regulator
D9N00_RS16080	COG1609	Transcriptional regulator
D9N00_RS16085	COG2115	Belongs to the xylose isomerase family
D9N00_RS16090	COG4213	ABC transporter substrate-binding protein
D9N00_RS16095	COG1129	ABC transporter
D9N00_RS16100	COG4214	carbohydrate transport
D9N00_RS16155	COG0673	inositol 2-dehydrogenase activity
D9N00_RS16180	COG2199	diguanylate cyclase activity
D9N00_RS16180	COG2202	Pas domain
D9N00_RS16180	COG2200	EAL domain
D9N00_RS16195	COG3121	Chaperone
D9N00_RS16200	COG3188	usher protein
D9N00_RS16210	COG3121	Chaperone
D9N00_RS16230	COG0322	excinuclease ABC activity
D9N00_RS16235	COG2197	response regulator
D9N00_RS16255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D9N00_RS16260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9N00_RS16265	COG4166	transmembrane transport
D9N00_RS16270	COG4174	ABC transporter (Permease)
D9N00_RS16275	COG4239	(ABC) transporter, permease
D9N00_RS16280	COG4172	Belongs to the ABC transporter superfamily
D9N00_RS16300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9N00_RS16365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS16380	COG1253	flavin adenine dinucleotide binding
D9N00_RS16390	COG0583	DNA-binding transcription factor activity
D9N00_RS16405	COG3132	Protein of unknown function, DUF480
D9N00_RS16410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9N00_RS16430	COG1686	Belongs to the peptidase S11 family
D9N00_RS16455	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS16470	COG2267	carboxylic ester hydrolase activity
D9N00_RS16475	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS16500	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9N00_RS16505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D9N00_RS16510	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9N00_RS16520	COG3842	ATPase activity
D9N00_RS16525	COG0583	DNA-binding transcription factor activity
D9N00_RS16535	COG0583	DNA-binding transcription factor activity
D9N00_RS16540	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS16555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9N00_RS16565	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D9N00_RS16570	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9N00_RS16575	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9N00_RS16580	COG2080	2 iron, 2 sulfur cluster binding
D9N00_RS16585	COG0579	oxidoreductase
D9N00_RS16590	COG4251	negative regulation of phosphorylation
D9N00_RS16615	COG4792	protein secretion
D9N00_RS16620	COG4791	protein targeting
D9N00_RS16630	COG4790	Type iii secretion
D9N00_RS16635	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9N00_RS16660	COG4669	(LipO)protein
D9N00_RS16690	COG4964	Belongs to the GSP D family
D9N00_RS16750	COG3713	MltA-interacting MipA family protein
D9N00_RS16760	COG0642	Histidine kinase
D9N00_RS16770	COG1301	dicarboxylic acid transport
D9N00_RS16780	COG1609	Transcriptional regulator
D9N00_RS16785	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS16790	COG1129	ABC transporter
D9N00_RS16795	COG1879	ABC-type sugar transport system periplasmic component
D9N00_RS16800	COG3386	PFAM SMP-30 Gluconolaconase
D9N00_RS16810	COG0803	Belongs to the bacterial solute-binding protein 9 family
D9N00_RS16820	COG1121	(ABC) transporter
D9N00_RS16835	COG0384	phenazine biosynthesis protein PhzF
D9N00_RS16840	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9N00_RS16845	COG0417	DNA replication proofreading
D9N00_RS16850	COG0517	IMP dehydrogenase activity
D9N00_RS16865	COG0583	DNA-binding transcription factor activity
D9N00_RS16870	COG0840	transmembrane signaling receptor activity
D9N00_RS16885	COG2175	clavaminate synthase activity
D9N00_RS16890	COG1247	-acetyltransferase
D9N00_RS16895	COG0124	histidyl-tRNA synthetase
D9N00_RS16900	COG0583	DNA-binding transcription factor activity
D9N00_RS16905	COG0604	alcohol dehydrogenase
D9N00_RS16925	COG1999	signal sequence binding
D9N00_RS16930	COG4206	TonB-dependent receptor
D9N00_RS16935	COG4977	sequence-specific DNA binding
D9N00_RS16940	COG4771	TonB-dependent receptor
D9N00_RS16945	COG2375	cellular response to nickel ion
D9N00_RS16945	COG1132	(ABC) transporter
D9N00_RS16955	COG3433	isochorismatase activity
D9N00_RS16955	COG2226	methyltransferase
D9N00_RS16955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9N00_RS16980	COG1021	2,3-dihydroxybenzoate-AMP ligase
D9N00_RS17000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS17010	COG5001	Diguanylate cyclase
D9N00_RS17025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9N00_RS17050	COG0069	glutamate synthase activity
D9N00_RS17055	COG2218	PFAM glutamate synthase alpha subunit domain protein
D9N00_RS17060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D9N00_RS17085	COG1469	GTP cyclohydrolase I activity
D9N00_RS17090	COG0583	DNA-binding transcription factor activity
D9N00_RS17105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS17110	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS17115	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS17130	COG0154	amidase activity
D9N00_RS17160	COG0840	transmembrane signaling receptor activity
D9N00_RS17260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9N00_RS17275	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9N00_RS17275	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D9N00_RS17285	COG0840	transmembrane signaling receptor activity
D9N00_RS17365	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9N00_RS17375	COG1120	ATPase activity
D9N00_RS17380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS17385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS17390	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D9N00_RS17395	COG4264	IucA IucC family
D9N00_RS17405	COG4264	IucA IucC family
D9N00_RS17410	COG2814	Major facilitator Superfamily
D9N00_RS17415	COG0019	diaminopimelate decarboxylase activity
D9N00_RS17420	COG4264	IucA IucC family
D9N00_RS17425	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS17435	COG3712	iron ion homeostasis
D9N00_RS17440	COG1595	DNA-templated transcription, initiation
D9N00_RS17450	COG1595	DNA-templated transcription, initiation
D9N00_RS17460	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS17465	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS17470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS17475	COG0601	transmembrane transport
D9N00_RS17550	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS17555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS17595	COG1253	flavin adenine dinucleotide binding
D9N00_RS17625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9N00_RS17640	COG1414	Transcriptional regulator
D9N00_RS17645	COG3842	ATPase activity
D9N00_RS17650	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9N00_RS17655	COG1177	transmembrane transport
D9N00_RS17685	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D9N00_RS17715	COG0028	Belongs to the TPP enzyme family
D9N00_RS17720	COG0768	penicillin binding
D9N00_RS17725	COG1733	regulation of RNA biosynthetic process
D9N00_RS17730	COG0702	epimerase
D9N00_RS17775	COG2271	Major facilitator Superfamily
D9N00_RS17790	COG2271	Major facilitator Superfamily
D9N00_RS17810	COG3387	PFAM Glycoside hydrolase 15-related
D9N00_RS17820	COG0667	Aldo Keto reductase
D9N00_RS17835	COG2066	Belongs to the glutaminase family
D9N00_RS17840	COG0235	Class ii aldolase
D9N00_RS17895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D9N00_RS17900	COG0251	oxidation-reduction process
D9N00_RS17915	COG0840	transmembrane signaling receptor activity
D9N00_RS17955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D9N00_RS17960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D9N00_RS17965	COG3454	Phosphonate metabolism
D9N00_RS17970	COG4778	phosphonate C-P lyase system protein PhnL
D9N00_RS17975	COG4107	phosphonate C-P lyase system protein PhnK
D9N00_RS17980	COG3627	carbon phosphorus lyase activity
D9N00_RS17985	COG3626	phosphonate metabolism
D9N00_RS17995	COG3624	Phosphonate C-P lyase system protein PhnG
D9N00_RS18000	COG2188	Transcriptional regulator
D9N00_RS18005	COG3639	organic phosphonate transmembrane transporter activity
D9N00_RS18015	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D9N00_RS18050	COG1484	DNA-dependent DNA replication
D9N00_RS18090	COG0776	regulation of translation
D9N00_RS18095	COG0072	phenylalanine-tRNA ligase activity
D9N00_RS18100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9N00_RS18105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D9N00_RS18110	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9N00_RS18115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9N00_RS18120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9N00_RS18130	COG1278	Cold shock
D9N00_RS18140	COG2706	6-phosphogluconolactonase activity
D9N00_RS18155	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D9N00_RS18190	COG1538	Outer membrane efflux protein
D9N00_RS18195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9N00_RS18215	COG0583	DNA-binding transcription factor activity
D9N00_RS18225	COG0729	surface antigen
D9N00_RS18235	COG0708	Exodeoxyribonuclease III
D9N00_RS18240	COG2885	chlorophyll binding
D9N00_RS18245	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS18255	COG0789	Transcriptional regulator
D9N00_RS18270	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS18275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D9N00_RS18280	COG1024	Enoyl-CoA hydratase
D9N00_RS18290	COG0316	Belongs to the HesB IscA family
D9N00_RS18290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9N00_RS18295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9N00_RS18310	COG1879	ABC-type sugar transport system periplasmic component
D9N00_RS18345	COG0616	signal peptide processing
D9N00_RS18370	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS18385	COG2816	NAD+ diphosphatase activity
D9N00_RS18390	COG1024	Enoyl-CoA hydratase
D9N00_RS18395	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D9N00_RS18410	COG0784	Response regulator, receiver
D9N00_RS18410	COG2205	protein histidine kinase activity
D9N00_RS18410	COG5002	protein histidine kinase activity
D9N00_RS18420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D9N00_RS18430	COG0745	RESPONSE REGULATOR receiver
D9N00_RS18450	COG1653	transport
D9N00_RS18455	COG1175	transmembrane transport
D9N00_RS18470	COG0246	Mannitol dehydrogenase
D9N00_RS18475	COG1070	Carbohydrate kinase
D9N00_RS18505	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9N00_RS18505	COG1199	ATP-dependent helicase activity
D9N00_RS18520	COG0604	alcohol dehydrogenase
D9N00_RS18520	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS18520	COG3321	synthase
D9N00_RS18590	COG3609	addiction module antidote protein, CC2985 family
D9N00_RS18600	COG1484	DNA-dependent DNA replication
D9N00_RS18630	COG1309	transcriptional regulator
D9N00_RS18635	COG0456	acetyltransferase
D9N00_RS18640	COG1132	(ABC) transporter
D9N00_RS18645	COG2207	Transcriptional regulator
D9N00_RS18650	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS18655	COG2207	Transcriptional regulator
D9N00_RS18665	COG1309	transcriptional regulator
D9N00_RS18670	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS18680	COG0702	epimerase
D9N00_RS18690	COG0583	DNA-binding transcription factor activity
D9N00_RS18700	COG1126	abc transporter atp-binding protein
D9N00_RS18710	COG0765	amino acid transport
D9N00_RS18730	COG0601	transmembrane transport
D9N00_RS18735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS18775	COG1335	isochorismatase
D9N00_RS18790	COG1196	nuclear chromosome segregation
D9N00_RS18825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D9N00_RS18835	COG2135	peptidase activity
D9N00_RS18865	COG3179	chitinase
D9N00_RS19265	COG2205	protein histidine kinase activity
D9N00_RS19270	COG0745	RESPONSE REGULATOR receiver
D9N00_RS19320	COG1022	Amp-dependent synthetase and ligase
D9N00_RS19330	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS19370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9N00_RS19380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D9N00_RS19385	COG0463	Glycosyl transferase, family 2
D9N00_RS19390	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9N00_RS19390	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9N00_RS19395	COG0726	polysaccharide deacetylase
D9N00_RS19400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D9N00_RS19405	COG2076	Multidrug Resistance protein
D9N00_RS19410	COG2076	Multidrug Resistance protein
D9N00_RS19425	COG1368	sulfuric ester hydrolase activity
D9N00_RS19445	COG0642	Histidine kinase
D9N00_RS19460	COG0642	Histidine kinase
D9N00_RS19480	COG3712	iron ion homeostasis
D9N00_RS19485	COG4774	siderophore transport
D9N00_RS19525	COG4191	Histidine kinase
D9N00_RS19525	COG0784	Response regulator, receiver
D9N00_RS19540	COG1917	Cupin 2, conserved barrel domain protein
D9N00_RS19540	COG1396	sequence-specific DNA binding
D9N00_RS19570	COG5001	Diguanylate cyclase
D9N00_RS19575	COG1957	nucleoside hydrolase
D9N00_RS19585	COG0583	DNA-binding transcription factor activity
D9N00_RS19595	COG4948	Mandelate Racemase Muconate Lactonizing
D9N00_RS19600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS19610	COG0765	amino acid transport
D9N00_RS19620	COG4221	oxidoreductase activity
D9N00_RS19625	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9N00_RS19635	COG1984	allophanate hydrolase subunit 2
D9N00_RS19640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D9N00_RS19650	COG0511	ligase activity, forming carbon-carbon bonds
D9N00_RS19665	COG0436	Aminotransferase
D9N00_RS19750	COG1984	allophanate hydrolase subunit 2
D9N00_RS19765	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D9N00_RS19780	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D9N00_RS19790	COG0251	oxidation-reduction process
D9N00_RS19800	COG0183	Belongs to the thiolase family
D9N00_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS19820	COG1024	Enoyl-CoA hydratase
D9N00_RS19835	COG2814	Major facilitator Superfamily
D9N00_RS19895	COG4977	sequence-specific DNA binding
D9N00_RS19910	COG1280	lysine exporter protein (LysE YggA)
D9N00_RS19925	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D9N00_RS19950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D9N00_RS19960	COG0604	alcohol dehydrogenase
D9N00_RS19965	COG1309	transcriptional regulator
D9N00_RS19985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D9N00_RS20060	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D9N00_RS20065	COG0830	nickel cation binding
D9N00_RS20070	COG0832	Belongs to the urease beta subunit family
D9N00_RS20070	COG0831	urea catabolic process
D9N00_RS20075	COG0804	urea catabolic process
D9N00_RS20080	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D9N00_RS20085	COG0829	nickel cation binding
D9N00_RS20090	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS20095	COG0640	Transcriptional regulator
D9N00_RS20100	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9N00_RS20105	COG3958	Transketolase
D9N00_RS20110	COG3959	Transketolase, thiamine diphosphate binding domain
D9N00_RS20115	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS20120	COG1879	ABC-type sugar transport system periplasmic component
D9N00_RS20125	COG1129	ABC transporter
D9N00_RS20130	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS20210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D9N00_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS20240	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D9N00_RS20270	COG1138	Cytochrome C-type biogenesis protein
D9N00_RS20275	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D9N00_RS20295	COG4133	protoheme IX ABC transporter activity
D9N00_RS20305	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9N00_RS20310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D9N00_RS20325	COG0251	oxidation-reduction process
D9N00_RS20365	COG1376	ErfK ybiS ycfS ynhG family protein
D9N00_RS20380	COG4181	ATPase activity
D9N00_RS20385	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
D9N00_RS20405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9N00_RS20420	COG2259	Doxx family
D9N00_RS20465	COG0714	Associated with various cellular activities
D9N00_RS20485	COG0745	RESPONSE REGULATOR receiver
D9N00_RS20490	COG2205	protein histidine kinase activity
D9N00_RS20495	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D9N00_RS20505	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
D9N00_RS20520	COG3328	transposase activity
D9N00_RS20545	COG2205	protein histidine kinase activity
D9N00_RS20580	COG0628	permease
D9N00_RS20605	COG2062	phosphohistidine phosphatase, SixA
D9N00_RS20615	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D9N00_RS20620	COG0784	Response regulator, receiver
D9N00_RS20620	COG2205	protein histidine kinase activity
D9N00_RS20620	COG5002	protein histidine kinase activity
D9N00_RS20630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9N00_RS20650	COG0326	Molecular chaperone. Has ATPase activity
D9N00_RS20695	COG3171	Protein conserved in bacteria
D9N00_RS20710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9N00_RS20710	COG0116	Belongs to the methyltransferase superfamily
D9N00_RS20715	COG3130	regulation of translation
D9N00_RS20720	COG0167	dihydroorotate dehydrogenase activity
D9N00_RS20730	COG1116	anion transmembrane transporter activity
D9N00_RS20730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D9N00_RS20735	COG3707	response regulator
D9N00_RS20745	COG2223	nitrite transmembrane transporter activity
D9N00_RS20750	COG0515	serine threonine protein kinase
D9N00_RS20750	COG2815	serine threonine protein kinase
D9N00_RS20755	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D9N00_RS20760	COG0243	molybdopterin cofactor binding
D9N00_RS20765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D9N00_RS20780	COG0668	transmembrane transport
D9N00_RS20795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D9N00_RS20810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D9N00_RS20825	COG0372	Belongs to the citrate synthase family
D9N00_RS20835	COG1802	Transcriptional regulator
D9N00_RS20840	COG4067	protein conserved in archaea
D9N00_RS20840	COG0189	ligase activity
D9N00_RS20885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D9N00_RS20925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9N00_RS20930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9N00_RS20945	COG0668	transmembrane transport
D9N00_RS20960	COG0456	acetyltransferase
D9N00_RS20960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D9N00_RS20970	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9N00_RS20975	COG3115	cell septum assembly
D9N00_RS20980	COG1196	nuclear chromosome segregation
D9N00_RS21005	COG0402	S-adenosylhomocysteine deaminase activity
D9N00_RS21035	COG4266	Belongs to the allantoicase family
D9N00_RS21040	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D9N00_RS21070	COG2354	Protein conserved in bacteria
D9N00_RS21080	COG1522	sequence-specific DNA binding
D9N00_RS21085	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D9N00_RS21100	COG0583	DNA-binding transcription factor activity
D9N00_RS21110	COG0840	transmembrane signaling receptor activity
D9N00_RS21125	COG1408	metallophosphoesterase
D9N00_RS21160	COG3046	protein related to deoxyribodipyrimidine photolyase
D9N00_RS21190	COG1472	Belongs to the glycosyl hydrolase 3 family
D9N00_RS21215	COG0840	transmembrane signaling receptor activity
D9N00_RS21220	COG0656	L-ascorbic acid biosynthetic process
D9N00_RS21230	COG0306	phosphate transporter
D9N00_RS21255	COG1024	Enoyl-CoA hydratase
D9N00_RS21260	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS21270	COG0431	NADPH-dependent FMN reductase
D9N00_RS21285	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9N00_RS21290	COG0328	RNA-DNA hybrid ribonuclease activity
D9N00_RS21300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D9N00_RS21305	COG0741	lytic transglycosylase activity
D9N00_RS21305	COG1388	LysM domain
D9N00_RS21310	COG4166	transmembrane transport
D9N00_RS21315	COG4166	transmembrane transport
D9N00_RS21320	COG4174	ABC transporter (Permease)
D9N00_RS21325	COG4239	(ABC) transporter, permease
D9N00_RS21330	COG4172	Belongs to the ABC transporter superfamily
D9N00_RS21340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9N00_RS21345	COG0776	regulation of translation
D9N00_RS21350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9N00_RS21355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9N00_RS21360	COG0740	serine-type endopeptidase activity
D9N00_RS21365	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9N00_RS21395	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9N00_RS21410	COG0395	ABC-type sugar transport system, permease component
D9N00_RS21420	COG3842	ATPase activity
D9N00_RS21425	COG3842	ATPase activity
D9N00_RS21430	COG3284	Transcriptional regulator
D9N00_RS21440	COG0215	cysteine-tRNA ligase activity
D9N00_RS21445	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9N00_RS21455	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D9N00_RS21480	COG2814	Major facilitator Superfamily
D9N00_RS21485	COG1566	PFAM secretion protein HlyD family protein
D9N00_RS21490	COG1846	Transcriptional regulator
D9N00_RS21510	COG1971	Probably functions as a manganese efflux pump
D9N00_RS21530	COG0714	Associated with various cellular activities
D9N00_RS21545	COG2304	oxidoreductase activity
D9N00_RS21560	COG0420	3'-5' exonuclease activity
D9N00_RS21580	COG2706	6-phosphogluconolactonase activity
D9N00_RS21610	COG1609	Transcriptional regulator
D9N00_RS21625	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS21630	COG2433	Pfam Transposase IS66
D9N00_RS21675	COG0754	glutathionylspermidine amidase activity
D9N00_RS21685	COG3766	membrane
D9N00_RS21715	COG0308	aminopeptidase N
D9N00_RS21725	COG3139	Protein of unknown function (DUF1315)
D9N00_RS21730	COG0705	Rhomboid family
D9N00_RS21735	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9N00_RS21740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9N00_RS21765	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D9N00_RS21770	COG2223	nitrite transmembrane transporter activity
D9N00_RS21785	COG0673	inositol 2-dehydrogenase activity
D9N00_RS21795	COG0673	inositol 2-dehydrogenase activity
D9N00_RS21800	COG3962	Belongs to the TPP enzyme family
D9N00_RS21815	COG3718	enzyme involved in inositol metabolism
D9N00_RS21825	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D9N00_RS21835	COG0392	lysyltransferase activity
D9N00_RS21840	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9N00_RS21845	COG3568	Endonuclease Exonuclease Phosphatase
D9N00_RS21855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D9N00_RS21875	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D9N00_RS21905	COG0183	Belongs to the thiolase family
D9N00_RS21910	COG1024	Enoyl-CoA hydratase
D9N00_RS21910	COG1250	3-hydroxyacyl-CoA dehydrogenase
D9N00_RS21950	COG0589	response to stress
D9N00_RS21955	COG0488	(ABC) transporter
D9N00_RS21960	COG0741	lytic transglycosylase activity
D9N00_RS21965	COG0633	Ferredoxin
D9N00_RS21965	COG3217	Mosc domain protein beta barrel domain protein
D9N00_RS21980	COG2197	response regulator
D9N00_RS21985	COG1597	lipid kinase activity
D9N00_RS21995	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D9N00_RS22000	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D9N00_RS22000	COG0662	Cupin 2, conserved barrel domain protein
D9N00_RS22045	COG0728	peptidoglycan biosynthetic process
D9N00_RS22050	COG0583	DNA-binding transcription factor activity
D9N00_RS22105	COG0179	Fumarylacetoacetate (FAA) hydrolase
D9N00_RS22110	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
D9N00_RS22130	COG0277	FAD linked oxidase domain protein
D9N00_RS22135	COG0277	FAD linked oxidase domain protein
D9N00_RS22160	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS22160	COG0446	pyridine nucleotide-disulphide oxidoreductase
D9N00_RS22180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D9N00_RS22225	COG1286	toxin biosynthetic process
D9N00_RS22235	COG0285	dihydrofolate synthase activity
D9N00_RS22240	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D9N00_RS22245	COG0135	phosphoribosylanthranilate isomerase activity
D9N00_RS22285	COG0084	hydrolase, TatD family'
D9N00_RS22300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9N00_RS22305	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D9N00_RS22315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9N00_RS22320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9N00_RS22335	COG0416	fatty acid biosynthetic process
D9N00_RS22340	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9N00_RS22350	COG0424	maF-like protein
D9N00_RS22355	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D9N00_RS22355	COG0616	signal peptide processing
D9N00_RS22360	COG0546	phosphoglycolate phosphatase activity
D9N00_RS22370	COG1530	ribonuclease E activity
D9N00_RS22375	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D9N00_RS22380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D9N00_RS22385	COG2835	tetraacyldisaccharide 4'-kinase activity
D9N00_RS22390	COG1663	tetraacyldisaccharide 4'-kinase activity
D9N00_RS22395	COG0848	biopolymer transport protein
D9N00_RS22400	COG0811	peptide transport
D9N00_RS22455	COG0842	Transport permease protein
D9N00_RS22460	COG1131	(ABC) transporter
D9N00_RS22465	COG0625	glutathione transferase activity
D9N00_RS22470	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS22490	COG1560	Kdo2-lipid A biosynthetic process
D9N00_RS22495	COG0850	regulation of cytokinetic process
D9N00_RS22500	COG2894	cell division
D9N00_RS22505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9N00_RS22510	COG0564	pseudouridine synthase activity
D9N00_RS22515	COG1362	aminopeptidase activity
D9N00_RS22565	COG2200	EAL domain
D9N00_RS22605	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9N00_RS22625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9N00_RS22630	COG0477	Major facilitator Superfamily
D9N00_RS22655	COG0385	Bile acid
D9N00_RS22660	COG2974	May be involved in recombination
D9N00_RS22710	COG1484	DNA-dependent DNA replication
D9N00_RS22885	COG0840	transmembrane signaling receptor activity
D9N00_RS22905	COG0514	ATP-dependent DNA helicase (RecQ)
D9N00_RS22915	COG2832	Protein of unknown function (DUF454)
D9N00_RS22920	COG2326	polyphosphate kinase activity
D9N00_RS22925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D9N00_RS22925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS22930	COG4181	ATPase activity
D9N00_RS22950	COG0367	asparagine synthase
D9N00_RS22955	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9N00_RS22955	COG0189	ligase activity
D9N00_RS22960	COG1363	Peptidase, m42
D9N00_RS22965	COG3089	Belongs to the UPF0270 family
D9N00_RS22970	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9N00_RS22975	COG1742	UPF0060 membrane protein
D9N00_RS23000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D9N00_RS23005	COG3162	membrane
D9N00_RS23025	COG2853	Lipoprotein
D9N00_RS23035	COG0583	DNA-binding transcription factor activity
D9N00_RS23045	COG3706	GGDEF domain
D9N00_RS23070	COG2197	response regulator
D9N00_RS23075	COG0477	Major facilitator Superfamily
D9N00_RS23100	COG2133	pyrroloquinoline quinone binding
D9N00_RS23115	COG2205	protein histidine kinase activity
D9N00_RS23120	COG0596	Alpha beta hydrolase
D9N00_RS23125	COG0590	tRNA wobble adenosine to inosine editing
D9N00_RS23145	COG0242	peptide deformylase activity
D9N00_RS23150	COG1295	ribonuclease BN
D9N00_RS23155	COG3237	CsbD-like
D9N00_RS23185	COG2996	Protein conserved in bacteria
D9N00_RS23220	COG0513	Belongs to the DEAD box helicase family
D9N00_RS23235	COG0745	RESPONSE REGULATOR receiver
D9N00_RS23300	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS23330	COG2267	carboxylic ester hydrolase activity
D9N00_RS23340	COG1132	(ABC) transporter
D9N00_RS23360	COG1643	Atp-dependent helicase
D9N00_RS23370	COG2026	Addiction module toxin, RelE StbE family
D9N00_RS23380	COG0318	PFAM AMP-dependent synthetase and ligase
D9N00_RS23390	COG2030	dehydratase
D9N00_RS23395	COG3866	Pectate lyase
D9N00_RS23410	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D9N00_RS23435	COG2271	Major facilitator Superfamily
D9N00_RS23485	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
D9N00_RS23505	COG0259	pyridoxamine-phosphate oxidase activity
D9N00_RS23520	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D9N00_RS23525	COG1199	ATP-dependent helicase activity
D9N00_RS23560	COG3012	SEC-C Motif Domain Protein
D9N00_RS23600	COG0653	protein targeting
D9N00_RS23605	COG2366	antibiotic biosynthetic process
D9N00_RS23610	COG1793	dna ligase
D9N00_RS23610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D9N00_RS23615	COG1793	dna ligase
D9N00_RS23650	COG1201	RNA secondary structure unwinding
D9N00_RS23665	COG0717	Belongs to the dCTP deaminase family
D9N00_RS23670	COG1278	Cold shock
D9N00_RS23675	COG0489	protein tyrosine kinase activity
D9N00_RS23680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9N00_RS23680	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9N00_RS23685	COG2878	Part of a membrane complex involved in electron transport
D9N00_RS23690	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D9N00_RS23715	COG0137	argininosuccinate synthase activity
D9N00_RS23725	COG0418	dihydroorotase activity
D9N00_RS23730	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9N00_RS23745	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9N00_RS23750	COG0243	molybdopterin cofactor binding
D9N00_RS23760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9N00_RS23770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D9N00_RS23780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D9N00_RS23805	COG0765	amino acid transport
D9N00_RS23810	COG0765	amino acid transport
D9N00_RS23815	COG1126	abc transporter atp-binding protein
D9N00_RS23855	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D9N00_RS23860	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9N00_RS23865	COG0583	DNA-binding transcription factor activity
D9N00_RS23875	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9N00_RS23880	COG0254	rRNA binding
D9N00_RS23945	COG1695	Transcriptional regulator
D9N00_RS23950	COG2375	cellular response to nickel ion
D9N00_RS23960	COG4628	conserved protein (DUF2132)
D9N00_RS23995	COG0523	cobalamin synthesis protein
D9N00_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS24010	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS24030	COG2188	Transcriptional regulator
D9N00_RS24075	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9N00_RS24085	COG2226	methyltransferase
D9N00_RS24090	COG0500	methyltransferase
D9N00_RS24095	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D9N00_RS24100	COG1381	Involved in DNA repair and RecF pathway recombination
D9N00_RS24105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9N00_RS24110	COG0571	ribonuclease III activity
D9N00_RS24120	COG0681	Belongs to the peptidase S26 family
D9N00_RS24125	COG0481	GTPase activity
D9N00_RS24130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9N00_RS24160	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
D9N00_RS24165	COG0354	folic acid binding
D9N00_RS24175	COG0642	Histidine kinase
D9N00_RS24205	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D9N00_RS24230	COG3842	ATPase activity
D9N00_RS24240	COG3665	Urea carboxylase-associated protein
D9N00_RS24280	COG2267	carboxylic ester hydrolase activity
D9N00_RS24340	COG1454	alcohol dehydrogenase
D9N00_RS24375	COG4191	Histidine kinase
D9N00_RS24380	COG2204	response regulator
D9N00_RS24385	COG4191	Histidine kinase
D9N00_RS24385	COG0784	Response regulator, receiver
D9N00_RS24390	COG0443	Heat shock 70 kDa protein
D9N00_RS24440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D9N00_RS24445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D9N00_RS24455	COG0477	Major facilitator Superfamily
D9N00_RS24460	COG0183	Belongs to the thiolase family
D9N00_RS24465	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D9N00_RS24470	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D9N00_RS24475	COG1414	Transcriptional regulator
D9N00_RS24485	COG0306	phosphate transporter
D9N00_RS24495	COG0788	formyltetrahydrofolate deformylase activity
D9N00_RS24505	COG2925	Exonuclease
D9N00_RS24545	COG0714	Associated with various cellular activities
D9N00_RS24565	COG0469	pyruvate kinase activity
D9N00_RS24615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9N00_RS24655	COG2814	Major facilitator Superfamily
D9N00_RS24660	COG1902	pentaerythritol trinitrate reductase activity
D9N00_RS24675	COG0583	DNA-binding transcription factor activity
D9N00_RS24750	COG3642	lipopolysaccharide core region biosynthetic process
D9N00_RS24760	COG0642	Histidine kinase
D9N00_RS24785	COG0459	protein refolding
D9N00_RS24790	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9N00_RS24800	COG3030	protein affecting phage T7 exclusion by the F plasmid
D9N00_RS24805	COG1028	Short-chain dehydrogenase reductase Sdr
D9N00_RS24815	COG3695	enzyme binding
D9N00_RS24820	COG2211	Major facilitator Superfamily
D9N00_RS24830	COG0668	transmembrane transport
D9N00_RS24835	COG1666	GTP binding
D9N00_RS24845	COG4191	Histidine kinase
D9N00_RS24845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D9N00_RS24850	COG2096	Adenosyltransferase
D9N00_RS24865	COG0494	nUDIX hydrolase
D9N00_RS24875	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D9N00_RS24880	COG0653	protein targeting
D9N00_RS24895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D9N00_RS24900	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9N00_RS24915	COG1181	Belongs to the D-alanine--D-alanine ligase family
D9N00_RS24920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9N00_RS24925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D9N00_RS24930	COG0772	Belongs to the SEDS family
D9N00_RS24935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D9N00_RS24940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D9N00_RS24945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D9N00_RS24950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D9N00_RS24965	COG0275	rRNA processing
D9N00_RS24970	COG2001	Belongs to the MraZ family
D9N00_RS24985	COG3107	peptidoglycan biosynthetic process
D9N00_RS24990	COG0792	nuclease activity
D9N00_RS24995	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D9N00_RS25000	COG2823	Periplasmic or secreted lipoprotein
D9N00_RS25005	COG2969	positive regulation of protein catabolic process
D9N00_RS25010	COG0625	glutathione transferase activity
D9N00_RS25015	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9N00_RS25020	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D9N00_RS25030	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D9N00_RS25035	COG0180	Tryptophanyl-tRNA synthetase
D9N00_RS25060	COG0175	sulfate reduction
D9N00_RS25070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9N00_RS25075	COG3011	Protein conserved in bacteria
D9N00_RS25085	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D9N00_RS25090	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9N00_RS25095	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D9N00_RS25105	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D9N00_RS25125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D9N00_RS25130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D9N00_RS25135	COG1127	ABC transporter
D9N00_RS25145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
D9N00_RS25155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D9N00_RS25160	COG1137	ATPase activity
D9N00_RS25165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D9N00_RS25170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D9N00_RS25180	COG1660	Displays ATPase and GTPase activities
D9N00_RS25215	COG0312	modulator of DNA gyrase
D9N00_RS25220	COG3028	Belongs to the UPF0307 family
D9N00_RS25225	COG0312	modulator of DNA gyrase
D9N00_RS25230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9N00_RS25240	COG1530	ribonuclease E activity
D9N00_RS25245	COG0424	maF-like protein
D9N00_RS25255	COG1792	Involved in formation and maintenance of cell shape
D9N00_RS25260	COG1077	Cell shape determining protein MreB Mrl
D9N00_RS25265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9N00_RS25270	COG0154	amidase activity
D9N00_RS25275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D9N00_RS25285	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D9N00_RS25295	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D9N00_RS25310	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D9N00_RS25325	COG2823	Periplasmic or secreted lipoprotein
D9N00_RS25330	COG1185	polyribonucleotide nucleotidyltransferase activity
D9N00_RS25340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9N00_RS25345	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9N00_RS25350	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9N00_RS25355	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9N00_RS25360	COG0195	Participates in both transcription termination and antitermination
D9N00_RS25365	COG0779	Required for maturation of 30S ribosomal subunits
D9N00_RS25380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D9N00_RS25385	COG0149	triose-phosphate isomerase activity
D9N00_RS25390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9N00_RS25395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D9N00_RS25405	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D9N00_RS25415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9N00_RS25420	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9N00_RS25425	COG0505	Belongs to the CarA family
D9N00_RS25435	COG0484	heat shock protein binding
D9N00_RS25440	COG0443	Heat shock 70 kDa protein
D9N00_RS25445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9N00_RS25455	COG0497	DNA recombination
D9N00_RS25465	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9N00_RS25480	COG2914	Belongs to the UPF0125 (RnfH) family
D9N00_RS25490	COG0733	neurotransmitter:sodium symporter activity
D9N00_RS25495	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D9N00_RS25585	COG1280	lysine exporter protein (LysE YggA)
D9N00_RS25620	COG2433	Pfam Transposase IS66
D9N00_RS25635	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS25640	COG1088	dTDP-glucose 4,6-dehydratase activity
D9N00_RS25645	COG1091	dTDP-4-dehydrorhamnose reductase activity
D9N00_RS25675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9N00_RS25680	COG0463	Glycosyl transferase, family 2
D9N00_RS25715	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D9N00_RS25745	COG0582	viral genome integration into host DNA
D9N00_RS25875	COG1595	DNA-templated transcription, initiation
D9N00_RS25900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D9N00_RS25905	COG0667	Aldo Keto reductase
D9N00_RS25965	COG1073	alpha beta
D9N00_RS25980	COG0840	transmembrane signaling receptor activity
D9N00_RS25985	COG0840	transmembrane signaling receptor activity
D9N00_RS26015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D9N00_RS26025	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D9N00_RS26070	COG1595	DNA-templated transcription, initiation
D9N00_RS26085	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9N00_RS26095	COG2204	response regulator
D9N00_RS26100	COG5642	Protein of unknown function (DUF2384)
D9N00_RS26105	COG5654	RES domain protein
D9N00_RS26135	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D9N00_RS26145	COG1215	transferase activity, transferring glycosyl groups
D9N00_RS26165	COG0811	peptide transport
D9N00_RS26190	COG3540	Alkaline phosphatase
D9N00_RS26195	COG1335	isochorismatase
D9N00_RS26265	COG2814	Major facilitator Superfamily
D9N00_RS26270	COG2824	Alkylphosphonate utilization operon protein PhnA
D9N00_RS26285	COG1418	mRNA catabolic process
D9N00_RS26295	COG0288	reversible hydration of carbon dioxide
D9N00_RS26305	COG0456	acetyltransferase
D9N00_RS26330	COG3012	SEC-C Motif Domain Protein
D9N00_RS26365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D9N00_RS26370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D9N00_RS26375	COG1183	phosphatidylcholine synthase activity
D9N00_RS26380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9N00_RS26390	COG0028	Belongs to the TPP enzyme family
D9N00_RS26410	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D9N00_RS26425	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D9N00_RS26435	COG1489	DNA binding
D9N00_RS26440	COG0436	Aminotransferase
D9N00_RS26445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D9N00_RS26470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9N00_RS26480	COG4191	Histidine kinase
D9N00_RS26485	COG2204	response regulator
D9N00_RS26500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D9N00_RS26505	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D9N00_RS26510	COG0166	Belongs to the GPI family
D9N00_RS26535	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
D9N00_RS26535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9N00_RS26535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D9N00_RS26540	COG1105	Belongs to the carbohydrate kinase PfkB family
D9N00_RS26550	COG1609	Transcriptional regulator
D9N00_RS26555	COG0084	hydrolase, TatD family'
D9N00_RS26570	COG3023	N-Acetylmuramoyl-L-alanine amidase
D9N00_RS26605	COG2304	oxidoreductase activity
D9N00_RS26650	COG1358	cellular component organization or biogenesis
D9N00_RS26690	COG1484	DNA-dependent DNA replication
D9N00_RS26715	COG4969	Belongs to the N-Me-Phe pilin family
D9N00_RS26735	COG0237	dephospho-CoA kinase activity
D9N00_RS26740	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D9N00_RS26780	COG1252	NADH dehydrogenase
D9N00_RS26800	COG0643	Histidine kinase
D9N00_RS26800	COG2198	Histidine kinase
D9N00_RS26805	COG0840	transmembrane signaling receptor activity
D9N00_RS26810	COG0835	chemotaxis
D9N00_RS26820	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D9N00_RS26825	COG2201	protein-glutamate methylesterase activity
D9N00_RS26860	COG1879	ABC-type sugar transport system periplasmic component
D9N00_RS26870	COG1172	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS26885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9N00_RS26955	COG1653	transport
D9N00_RS26975	COG1621	beta-fructofuranosidase activity
D9N00_RS27090	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS27095	COG2433	Pfam Transposase IS66
D9N00_RS27260	COG0542	response to heat
D9N00_RS27310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS27340	COG4969	Belongs to the N-Me-Phe pilin family
D9N00_RS27350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D9N00_RS27355	COG1047	Peptidyl-prolyl cis-trans
D9N00_RS27360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9N00_RS27365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9N00_RS27370	COG0196	riboflavin kinase activity
D9N00_RS27385	COG0268	Binds directly to 16S ribosomal RNA
D9N00_RS27390	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D9N00_RS27395	COG4372	Transposase
D9N00_RS27410	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS27415	COG3045	CreA protein
D9N00_RS27420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D9N00_RS27425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9N00_RS27430	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D9N00_RS27435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D9N00_RS27440	COG0142	geranyltranstransferase activity
D9N00_RS27450	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D9N00_RS27455	COG0709	Synthesizes selenophosphate from selenide and ATP
D9N00_RS27465	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
D9N00_RS27470	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D9N00_RS27475	COG3639	organic phosphonate transmembrane transporter activity
D9N00_RS27480	COG3639	organic phosphonate transmembrane transporter activity
D9N00_RS27490	COG0745	RESPONSE REGULATOR receiver
D9N00_RS27500	COG4771	TonB-dependent receptor
D9N00_RS27560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D9N00_RS27570	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D9N00_RS27580	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS27585	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS27590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS27595	COG0601	transmembrane transport
D9N00_RS27600	COG2197	response regulator
D9N00_RS27605	COG2267	carboxylic ester hydrolase activity
D9N00_RS27620	COG5001	Diguanylate cyclase
D9N00_RS27625	COG0730	response to heat
D9N00_RS27645	COG2721	sulfolactate sulfo-lyase activity
D9N00_RS27650	COG2271	Major facilitator Superfamily
D9N00_RS27655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D9N00_RS27665	COG2186	Transcriptional regulator
D9N00_RS27670	COG4178	(ABC) transporter
D9N00_RS27680	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D9N00_RS27700	COG0747	negative chemotaxis
D9N00_RS27705	COG0747	negative chemotaxis
D9N00_RS27710	COG0747	negative chemotaxis
D9N00_RS27720	COG0747	negative chemotaxis
D9N00_RS27725	COG0601	transmembrane transport
D9N00_RS27730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS27735	COG0444	Belongs to the ABC transporter superfamily
D9N00_RS27740	COG4608	Belongs to the ABC transporter superfamily
D9N00_RS27745	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D9N00_RS27760	COG0019	diaminopimelate decarboxylase activity
D9N00_RS27795	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D9N00_RS27805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9N00_RS27810	COG0545	Peptidyl-prolyl cis-trans isomerase
D9N00_RS27820	COG2862	Uncharacterized protein family, UPF0114
D9N00_RS27830	COG1067	ATP-dependent peptidase activity
D9N00_RS27860	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9N00_RS27865	COG0488	(ABC) transporter
D9N00_RS27875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9N00_RS27880	COG0523	cobalamin synthesis protein
D9N00_RS27885	COG2879	small protein
D9N00_RS27890	COG1966	Carbon starvation protein
D9N00_RS27905	COG1970	mechanosensitive ion channel activity
D9N00_RS27915	COG2197	response regulator
D9N00_RS27920	COG2813	Specifically methylates the guanine in position
D9N00_RS27930	COG1294	oxidase, subunit
D9N00_RS27935	COG1271	oxidase subunit
D9N00_RS27955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D9N00_RS27960	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D9N00_RS27965	COG2080	2 iron, 2 sulfur cluster binding
D9N00_RS27970	COG2252	PERMEase
D9N00_RS27975	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D9N00_RS27995	COG2321	neutral zinc metallopeptidase
D9N00_RS28010	COG0546	phosphoglycolate phosphatase activity
D9N00_RS28015	COG1946	Acyl-CoA thioesterase
D9N00_RS28025	COG0123	including yeast histone deacetylase and acetoin utilization protein
D9N00_RS28035	COG0513	Belongs to the DEAD box helicase family
D9N00_RS28040	COG1199	ATP-dependent helicase activity
D9N00_RS28040	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9N00_RS28055	COG3416	Protein conserved in bacteria
D9N00_RS28200	COG5599	Phosphatase
D9N00_RS28235	COG1484	DNA-dependent DNA replication
D9N00_RS28305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D9N00_RS28315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9N00_RS28350	COG1131	(ABC) transporter
D9N00_RS28360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D9N00_RS28485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D9N00_RS28500	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9N00_RS28555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D9N00_RS28560	COG1074	ATP-dependent DNA helicase activity
D9N00_RS28565	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
D9N00_RS28615	COG2233	PERMEase
D9N00_RS28620	COG1309	transcriptional regulator
D9N00_RS28630	COG3845	ABC transporter
D9N00_RS28650	COG1079	Belongs to the binding-protein-dependent transport system permease family
D9N00_RS28675	COG0387	Pfam Sodium calcium exchanger
D9N00_RS28680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D9N00_RS28685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS28690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS28695	COG1120	ATPase activity
D9N00_RS28710	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D9N00_RS28720	COG0583	DNA-binding transcription factor activity
D9N00_RS28730	COG2814	Major facilitator Superfamily
D9N00_RS28735	COG2217	Heavy metal translocating P-type atpase
D9N00_RS28795	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D9N00_RS28815	COG1346	cytolysis
D9N00_RS28835	COG0702	epimerase
D9N00_RS28850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D9N00_RS28870	COG4303	Ethanolamine ammonia lyase large subunit
D9N00_RS28875	COG4302	ethanolamine ammonia-lyase activity
D9N00_RS28885	COG0586	Pfam SNARE associated Golgi protein
D9N00_RS28890	COG3228	Belongs to the MtfA family
D9N00_RS28895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9N00_RS28940	COG0625	glutathione transferase activity
D9N00_RS28955	COG1722	exodeoxyribonuclease VII activity
D9N00_RS28960	COG0142	geranyltranstransferase activity
D9N00_RS28965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D9N00_RS28975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9N00_RS28980	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D9N00_RS28985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9N00_RS28990	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9N00_RS29005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9N00_RS29005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9N00_RS29010	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D9N00_RS29025	COG3118	belongs to the thioredoxin family
D9N00_RS29060	COG3047	cAMP biosynthetic process
D9N00_RS29075	COG0668	transmembrane transport
D9N00_RS29130	COG1653	transport
D9N00_RS29135	COG1175	transmembrane transport
D9N00_RS29145	COG3842	ATPase activity
D9N00_RS29150	COG0584	glycerophosphoryl diester phosphodiesterase
D9N00_RS29155	COG0483	inositol monophosphate 1-phosphatase activity
D9N00_RS29165	COG0629	single-stranded DNA binding
D9N00_RS29170	COG2814	Major facilitator Superfamily
D9N00_RS29175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D9N00_RS29180	COG2193	ferroxidase activity
D9N00_RS29185	COG0203	ribosomal protein L17
D9N00_RS29190	COG0202	RNA polymerase activity
D9N00_RS29195	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9N00_RS29200	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D9N00_RS29205	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9N00_RS29210	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9N00_RS29220	COG0200	Binds to the 23S rRNA
D9N00_RS29225	COG1841	ribosomal large subunit assembly
D9N00_RS29230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9N00_RS29235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D9N00_RS29240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9N00_RS29245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D9N00_RS29250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9N00_RS29255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9N00_RS29260	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9N00_RS29265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D9N00_RS29270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9N00_RS29275	COG0255	Belongs to the universal ribosomal protein uL29 family
D9N00_RS29280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9N00_RS29285	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9N00_RS29290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9N00_RS29295	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9N00_RS29300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9N00_RS29305	COG0089	rRNA binding
D9N00_RS29310	COG0088	Forms part of the polypeptide exit tunnel
D9N00_RS29315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9N00_RS29320	COG0051	transcription antitermination factor activity, RNA binding
D9N00_RS29325	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9N00_RS29330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D9N00_RS29335	COG0049	tRNA binding
D9N00_RS29340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9N00_RS29345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9N00_RS29350	COG0085	RNA polymerase activity
D9N00_RS29355	COG0222	ribosome binding
D9N00_RS29360	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9N00_RS29365	COG0081	regulation of translation
D9N00_RS29370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D9N00_RS29410	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D9N00_RS29450	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D9N00_RS29460	COG0739	heme binding
D9N00_RS29465	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D9N00_RS29470	COG0316	Belongs to the HesB IscA family
D9N00_RS29475	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D9N00_RS29480	COG1981	membrane
D9N00_RS29490	COG4221	oxidoreductase activity
D9N00_RS29495	COG0537	adenosine 5'-monophosphoramidase activity
D9N00_RS29500	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
D9N00_RS29505	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D9N00_RS29510	COG1765	OsmC-like protein
D9N00_RS29525	COG0134	indole-3-glycerol-phosphate synthase activity
D9N00_RS29530	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D9N00_RS29535	COG0512	Glutamine amidotransferase of anthranilate synthase
D9N00_RS29545	COG3179	chitinase
D9N00_RS29565	COG3299	homolog of phage Mu protein gp47
D9N00_RS29610	COG4386	tail sheath protein
D9N00_RS29695	COG0546	phosphoglycolate phosphatase activity
D9N00_RS29700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9N00_RS29710	COG1176	ABC-type spermidine putrescine transport system, permease component I
D9N00_RS29720	COG3842	ATPase activity
D9N00_RS29730	COG2197	response regulator
D9N00_RS29735	COG4585	Histidine kinase
D9N00_RS29745	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D9N00_RS29750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D9N00_RS29755	COG3178	'Phosphotransferase
D9N00_RS29760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D9N00_RS29765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D9N00_RS29770	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D9N00_RS29775	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9N00_RS29780	COG2967	ApaG domain
D9N00_RS29785	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9N00_RS29790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D9N00_RS29795	COG2766	serine protein kinase
D9N00_RS29800	COG2718	Belongs to the UPF0229 family
D9N00_RS29805	COG2719	SpoVR family
D9N00_RS29810	COG0617	tRNA 3'-terminal CCA addition
D9N00_RS29815	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D9N00_RS29820	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D9N00_RS29825	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D9N00_RS29830	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9N00_RS29835	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9N00_RS29840	COG0358	DNA primase activity
D9N00_RS29845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9N00_RS29945	COG0546	phosphoglycolate phosphatase activity
D9N00_RS29950	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
D9N00_RS29960	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9N00_RS29965	COG0019	diaminopimelate decarboxylase activity
D9N00_RS29975	COG1965	Belongs to the frataxin family
D9N00_RS29985	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D9N00_RS30005	COG1301	dicarboxylic acid transport
D9N00_RS30010	COG0189	ligase activity
D9N00_RS30015	COG0189	ligase activity
D9N00_RS30015	COG4067	protein conserved in archaea
D9N00_RS30020	COG3287	FIST C domain
D9N00_RS30020	COG2199	diguanylate cyclase activity
D9N00_RS30020	COG2200	EAL domain
D9N00_RS30025	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D9N00_RS30030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D9N00_RS30035	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D9N00_RS30105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS30110	COG0747	negative chemotaxis
D9N00_RS30115	COG0601	transmembrane transport
D9N00_RS30120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D9N00_RS30160	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D9N00_RS30165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D9N00_RS30175	COG1522	sequence-specific DNA binding
D9N00_RS30190	COG4172	Belongs to the ABC transporter superfamily
D9N00_RS30195	COG4239	(ABC) transporter, permease
D9N00_RS30200	COG4174	ABC transporter (Permease)
D9N00_RS30205	COG4166	transmembrane transport
D9N00_RS30240	COG1522	sequence-specific DNA binding
D9N00_RS30255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9N00_RS30265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D9N00_RS30275	COG0210	DNA helicase
D9N00_RS30330	COG3657	addiction module killer protein
D9N00_RS30365	COG1484	DNA-dependent DNA replication
D9N00_RS30390	COG0432	Pfam Uncharacterised protein family UPF0047
D9N00_RS30400	COG0004	ammonium transporteR
D9N00_RS30405	COG0347	Belongs to the P(II) protein family
D9N00_RS30425	COG3549	Plasmid maintenance system killer
D9N00_RS30430	COG0583	DNA-binding transcription factor activity
D9N00_RS30435	COG1126	abc transporter atp-binding protein
D9N00_RS30460	COG2072	flavoprotein involved in K transport
D9N00_RS30480	COG0583	DNA-binding transcription factor activity
D9N00_RS30490	COG0697	spore germination
D9N00_RS30530	COG0606	chelatase, subunit chli
D9N00_RS30545	COG2851	Citrate transporter
D9N00_RS30565	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D9N00_RS30580	COG0848	biopolymer transport protein
D9N00_RS30615	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D9N00_RS30620	COG1758	RNA polymerase activity
D9N00_RS30625	COG0194	GDP metabolic process
D9N00_RS30630	COG1561	YicC-like family, N-terminal region
D9N00_RS30635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D9N00_RS30645	COG0708	Exodeoxyribonuclease III
D9N00_RS30650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D9N00_RS30660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D9N00_RS30665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D9N00_RS30670	COG0756	dUTP diphosphatase activity
D9N00_RS30675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D9N00_RS30680	COG2003	Belongs to the UPF0758 family
D9N00_RS30685	COG0747	negative chemotaxis
D9N00_RS30695	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9N00_RS30700	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9N00_RS30710	COG1012	belongs to the aldehyde dehydrogenase family
D9N00_RS30725	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9N00_RS30730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D9N00_RS30740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS30755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D9N00_RS30765	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D9N00_RS30785	COG0427	acetyl-CoA hydrolase
D9N00_RS30810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D9N00_RS30825	COG0534	Mate efflux family protein
D9N00_RS30830	COG0583	DNA-binding transcription factor activity
D9N00_RS30845	COG1283	sodium-dependent phosphate transmembrane transporter activity
D9N00_RS30850	COG0612	Peptidase, M16
D9N00_RS30860	COG0700	Nucleoside recognition
D9N00_RS30865	COG0165	Argininosuccinate lyase
D9N00_RS30870	COG2972	Histidine kinase
D9N00_RS30870	COG0745	RESPONSE REGULATOR receiver
D9N00_RS30880	COG0181	hydroxymethylbilane synthase activity
D9N00_RS30900	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D9N00_RS30935	COG0488	(ABC) transporter
D9N00_RS30945	COG1280	lysine exporter protein (LysE YggA)
D9N00_RS30950	COG1335	isochorismatase
D9N00_RS30955	COG0583	DNA-binding transcription factor activity
D9N00_RS30960	COG0672	)-iron permease
D9N00_RS30970	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
D9N00_RS30980	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D9N00_RS31010	COG1764	response to oxidative stress
D9N00_RS31015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D9N00_RS31025	COG3360	Dodecin
D9N00_RS31040	COG0133	tryptophan synthase activity
D9N00_RS31045	COG0159	tryptophan synthase activity
D9N00_RS31085	COG0583	DNA-binding transcription factor activity
D9N00_RS31090	COG3119	arylsulfatase activity
D9N00_RS31105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9N00_RS31110	COG0408	coproporphyrinogen oxidase activity
D9N00_RS31120	COG0009	L-threonylcarbamoyladenylate synthase
D9N00_RS31125	COG0758	DNA mediated transformation
D9N00_RS31135	COG0242	peptide deformylase activity
D9N00_RS31140	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D9N00_RS31145	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D9N00_RS31150	COG0569	domain protein
D9N00_RS31175	COG2818	Glycosylase
D9N00_RS31180	COG0752	glycyl-tRNA synthetase alpha subunit
D9N00_RS31185	COG0751	glycine-tRNA ligase activity
D9N00_RS31190	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9N00_RS31205	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D9N00_RS31215	COG0514	ATP-dependent DNA helicase (RecQ)
D9N00_RS31240	COG1484	DNA-dependent DNA replication
D9N00_RS31320	COG0668	transmembrane transport
D9N00_RS31330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D9N00_RS31335	COG0667	Aldo Keto reductase
D9N00_RS31340	COG1802	Transcriptional regulator
D9N00_RS31400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D9N00_RS31405	COG1960	acyl-CoA dehydrogenase activity
D9N00_RS31410	COG0583	DNA-binding transcription factor activity
D9N00_RS31430	COG0427	acetyl-CoA hydrolase
D9N00_RS31485	COG3161	chorismate lyase activity
D9N00_RS31490	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D9N00_RS31505	COG1253	flavin adenine dinucleotide binding
D9N00_RS31525	COG0704	Plays a role in the regulation of phosphate uptake
D9N00_RS31530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D9N00_RS31535	COG0573	inorganic phosphate transmembrane transporter activity
D9N00_RS31540	COG0573	inorganic phosphate transmembrane transporter activity
D9N00_RS31590	COG0583	DNA-binding transcription factor activity
D9N00_RS31595	COG1027	Aspartate ammonia-lyase
D9N00_RS31600	COG1115	amino acid carrier protein
D9N00_RS31605	COG0252	asparaginase activity
D9N00_RS31610	COG3781	membrane
D9N00_RS31615	COG2391	methyltransferase activity
D9N00_RS31640	COG5016	pyruvate
D9N00_RS31640	COG0511	ligase activity, forming carbon-carbon bonds
D9N00_RS31645	COG0439	Biotin carboxylase
D9N00_RS31650	COG0583	DNA-binding transcription factor activity
D9N00_RS31660	COG1737	Transcriptional regulator
D9N00_RS31665	COG0210	DNA helicase
D9N00_RS31680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D9N00_RS31680	COG4651	solute:proton antiporter activity
D9N00_RS31685	COG1607	acyl-coa hydrolase
D9N00_RS31690	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
D9N00_RS31700	COG0523	cobalamin synthesis protein
D9N00_RS31725	COG0860	N-Acetylmuramoyl-L-alanine amidase
D9N00_RS31735	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D9N00_RS31745	COG2184	nucleotidyltransferase activity
D9N00_RS31750	COG2217	Heavy metal translocating P-type atpase
D9N00_RS31750	COG2608	mercury ion transmembrane transporter activity
D9N00_RS31770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D9N00_RS31775	COG2267	carboxylic ester hydrolase activity
D9N00_RS31780	COG0671	phosphoesterase, PA-phosphatase related
D9N00_RS31780	COG2453	phosphatase
D9N00_RS31795	COG4589	Belongs to the CDS family
D9N00_RS31805	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
D9N00_RS31830	COG4566	intracellular signal transduction
D9N00_RS31835	COG4191	Histidine kinase
D9N00_RS31840	COG1116	anion transmembrane transporter activity
D9N00_RS31855	COG0840	transmembrane signaling receptor activity
D9N00_RS31885	COG0529	Catalyzes the synthesis of activated sulfate
D9N00_RS31895	COG2890	protein-(glutamine-N5) methyltransferase activity
D9N00_RS31905	COG1120	ATPase activity
D9N00_RS31915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D9N00_RS31950	COG0488	(ABC) transporter
D9N00_RS31955	COG1077	Cell shape determining protein MreB Mrl
D9N00_RS31970	COG1484	DNA-dependent DNA replication
D9N00_RS31990	COG1484	DNA-dependent DNA replication
D9N00_RS31995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D9N00_RS32025	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS32060	COG5001	Diguanylate cyclase
D9N00_RS32080	COG1649	PFAM Uncharacterised BCR, COG1649
D9N00_RS32115	COG4372	Transposase
D9N00_RS32130	COG3436	PFAM IS66 Orf2 family protein
D9N00_RS32160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D9N00_RS32165	COG1349	DNA-binding transcription factor activity
D9N00_RS32170	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D9N00_RS32175	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9N00_RS32180	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9N00_RS32185	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D9N00_RS32190	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9N00_RS32195	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9N00_RS32200	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9N00_RS32210	COG0356	it plays a direct role in the translocation of protons across the membrane
D9N00_RS32215	COG3312	ion transport
D9N00_RS32220	COG1475	DNA binding
D9N00_RS32225	COG1192	Involved in chromosome partitioning
D9N00_RS32230	COG0357	Ribosomal RNA small subunit methyltransferase G
D9N00_RS32235	COG0445	tRNA wobble uridine modification
D9N00_RS32240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D9N00_RS32245	COG0706	membrane insertase activity
D9N00_RS32250	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D9N00_RS32255	COG0594	ribonuclease P activity
D9N00_RS32260	COG0230	Belongs to the bacterial ribosomal protein bL34 family