locus-tag	class	description
AOC04_RS00020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AOC04_RS00025	COG4535	Mg2 and Co2 transporter CorC
AOC04_RS00030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOC04_RS00035	COG1702	phosphate starvation-inducible protein PhoH
AOC04_RS00040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOC04_RS00055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOC04_RS00060	COG0352	thiamine-phosphate diphosphorylase activity
AOC04_RS00065	COG0351	phosphomethylpyrimidine kinase
AOC04_RS00075	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS00080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AOC04_RS00095	COG1522	sequence-specific DNA binding
AOC04_RS00105	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AOC04_RS00115	COG1643	Atp-dependent helicase
AOC04_RS00145	COG0697	spore germination
AOC04_RS00150	COG0513	Belongs to the DEAD box helicase family
AOC04_RS00155	COG0493	'glutamate synthase
AOC04_RS00155	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOC04_RS00160	COG0123	including yeast histone deacetylase and acetoin utilization protein
AOC04_RS00170	COG1946	Acyl-CoA thioesterase
AOC04_RS00185	COG2321	neutral zinc metallopeptidase
AOC04_RS00190	COG0583	DNA-binding transcription factor activity
AOC04_RS00195	COG3485	protocatechuate 3,4-dioxygenase
AOC04_RS00200	COG3485	protocatechuate 3,4-dioxygenase
AOC04_RS00205	COG0697	spore germination
AOC04_RS00215	COG3185	4-Hydroxyphenylpyruvate dioxygenase
AOC04_RS00215	COG1082	Xylose isomerase domain protein TIM barrel
AOC04_RS00220	COG1309	transcriptional regulator
AOC04_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOC04_RS00230	COG2252	PERMEase
AOC04_RS00250	COG1271	oxidase subunit
AOC04_RS00255	COG1294	oxidase, subunit
AOC04_RS00265	COG2813	Specifically methylates the guanine in position
AOC04_RS00275	COG1970	mechanosensitive ion channel activity
AOC04_RS00295	COG1966	Carbon starvation protein
AOC04_RS00300	COG2879	small protein
AOC04_RS00305	COG0523	cobalamin synthesis protein
AOC04_RS00310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOC04_RS00320	COG0488	(ABC) transporter
AOC04_RS00330	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOC04_RS00350	COG1067	ATP-dependent peptidase activity
AOC04_RS00365	COG2862	Uncharacterized protein family, UPF0114
AOC04_RS00370	COG0545	Peptidyl-prolyl cis-trans isomerase
AOC04_RS00375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOC04_RS00380	COG2824	Alkylphosphonate utilization operon protein PhnA
AOC04_RS00385	COG0142	geranyltranstransferase activity
AOC04_RS00390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AOC04_RS00395	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOC04_RS00400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AOC04_RS00405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AOC04_RS00410	COG3045	CreA protein
AOC04_RS00415	COG0268	Binds directly to 16S ribosomal RNA
AOC04_RS00425	COG0196	riboflavin kinase activity
AOC04_RS00430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOC04_RS00435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AOC04_RS00440	COG1047	Peptidyl-prolyl cis-trans
AOC04_RS00445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOC04_RS00475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS00495	COG0542	response to heat
AOC04_RS00520	COG0531	amino acid
AOC04_RS00525	COG2066	Belongs to the glutaminase family
AOC04_RS00530	COG0076	glutamate decarboxylase activity
AOC04_RS00535	COG1252	NADH dehydrogenase
AOC04_RS00560	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOC04_RS00565	COG0237	dephospho-CoA kinase activity
AOC04_RS00570	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AOC04_RS00580	COG4969	Belongs to the N-Me-Phe pilin family
AOC04_RS00590	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AOC04_RS00610	COG3725	Membrane protein required for beta-lactamase induction
AOC04_RS00615	COG0084	hydrolase, TatD family'
AOC04_RS00620	COG1609	Transcriptional regulator
AOC04_RS00635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOC04_RS00635	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
AOC04_RS00635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AOC04_RS00645	COG4774	siderophore transport
AOC04_RS00650	COG3128	pkhd-type hydroxylase
AOC04_RS00660	COG0019	diaminopimelate decarboxylase activity
AOC04_RS00685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOC04_RS00700	COG4608	Belongs to the ABC transporter superfamily
AOC04_RS00705	COG0444	Belongs to the ABC transporter superfamily
AOC04_RS00710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS00715	COG0601	transmembrane transport
AOC04_RS00720	COG0747	negative chemotaxis
AOC04_RS00730	COG0747	negative chemotaxis
AOC04_RS00735	COG0747	negative chemotaxis
AOC04_RS00745	COG3852	Histidine kinase
AOC04_RS00750	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AOC04_RS00755	COG4178	(ABC) transporter
AOC04_RS00770	COG0579	oxidoreductase
AOC04_RS00800	COG2135	peptidase activity
AOC04_RS00805	COG0501	Belongs to the peptidase M48B family
AOC04_RS00810	COG2119	membrane
AOC04_RS00815	COG2813	Specifically methylates the guanine in position
AOC04_RS00820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOC04_RS00825	COG1280	lysine exporter protein (LysE YggA)
AOC04_RS00840	COG4215	(ABC) transporter
AOC04_RS00860	COG1737	Transcriptional regulator
AOC04_RS00865	COG2885	chlorophyll binding
AOC04_RS00880	COG0180	Tryptophanyl-tRNA synthetase
AOC04_RS00885	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOC04_RS00895	COG0667	Aldo Keto reductase
AOC04_RS00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOC04_RS00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOC04_RS00910	COG0723	plastoquinol--plastocyanin reductase activity
AOC04_RS00915	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOC04_RS00920	COG2857	Cytochrome c1
AOC04_RS00925	COG0625	glutathione transferase activity
AOC04_RS00930	COG2969	positive regulation of protein catabolic process
AOC04_RS00935	COG2823	Periplasmic or secreted lipoprotein
AOC04_RS00940	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AOC04_RS00945	COG0792	nuclease activity
AOC04_RS00950	COG3107	peptidoglycan biosynthetic process
AOC04_RS00965	COG2001	Belongs to the MraZ family
AOC04_RS00970	COG0275	rRNA processing
AOC04_RS00985	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOC04_RS00990	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOC04_RS00995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOC04_RS01000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AOC04_RS01005	COG0772	Belongs to the SEDS family
AOC04_RS01010	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AOC04_RS01015	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOC04_RS01020	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOC04_RS01035	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOC04_RS01040	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOC04_RS01045	COG2203	Gaf domain
AOC04_RS01045	COG4251	negative regulation of phosphorylation
AOC04_RS01045	COG5001	Diguanylate cyclase
AOC04_RS01045	COG3706	GGDEF domain
AOC04_RS01060	COG5002	protein histidine kinase activity
AOC04_RS01070	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS01100	COG3604	Transcriptional regulator
AOC04_RS01105	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOC04_RS01105	COG1017	nitric oxide dioxygenase activity
AOC04_RS01110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOC04_RS01120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOC04_RS01125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AOC04_RS01130	COG1845	cytochrome c oxidase, subunit III
AOC04_RS01140	COG0109	protoheme IX farnesyltransferase activity
AOC04_RS01160	COG1309	transcriptional regulator
AOC04_RS01175	COG1414	Transcriptional regulator
AOC04_RS01180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOC04_RS01185	COG4948	Mandelate Racemase Muconate Lactonizing
AOC04_RS01190	COG1063	alcohol dehydrogenase
AOC04_RS01195	COG2271	Major facilitator Superfamily
AOC04_RS01200	COG0246	Mannitol dehydrogenase
AOC04_RS01205	COG1312	Catalyzes the dehydration of D-mannonate
AOC04_RS01210	COG2234	aminopeptidase activity
AOC04_RS01215	COG0702	epimerase
AOC04_RS01220	COG0583	DNA-binding transcription factor activity
AOC04_RS01260	COG1063	alcohol dehydrogenase
AOC04_RS01275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS01280	COG3135	benzoate transporter
AOC04_RS01305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOC04_RS01360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOC04_RS01365	COG0343	queuine tRNA-ribosyltransferase activity
AOC04_RS01370	COG1862	Preprotein translocase
AOC04_RS01385	COG3134	Outer membrane lipoprotein
AOC04_RS01400	COG1045	serine acetyltransferase
AOC04_RS01410	COG1104	cysteine desulfurase activity
AOC04_RS01420	COG0316	Belongs to the HesB IscA family
AOC04_RS01425	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AOC04_RS01430	COG0443	Heat shock 70 kDa protein
AOC04_RS01435	COG0633	Ferredoxin
AOC04_RS01445	COG0105	UTP biosynthetic process
AOC04_RS01450	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AOC04_RS01460	COG1426	Protein conserved in bacteria
AOC04_RS01465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOC04_RS01470	COG0124	histidyl-tRNA synthetase
AOC04_RS01485	COG1160	GTP binding
AOC04_RS01490	COG0436	Aminotransferase
AOC04_RS01495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOC04_RS01500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOC04_RS01510	COG0739	heme binding
AOC04_RS01515	COG1570	exodeoxyribonuclease VII activity
AOC04_RS01535	COG0519	Catalyzes the synthesis of GMP from XMP
AOC04_RS01535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOC04_RS01545	COG0590	tRNA wobble adenosine to inosine editing
AOC04_RS01550	COG0500	methyltransferase
AOC04_RS01555	COG4106	trans-aconitate 2-methyltransferase activity
AOC04_RS01570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOC04_RS01585	COG4771	TonB-dependent receptor
AOC04_RS01590	COG4628	conserved protein (DUF2132)
AOC04_RS01600	COG2375	cellular response to nickel ion
AOC04_RS01605	COG1695	Transcriptional regulator
AOC04_RS01615	COG1113	amino acid transport
AOC04_RS01630	COG0069	glutamate synthase activity
AOC04_RS01635	COG0494	nUDIX hydrolase
AOC04_RS01640	COG1280	lysine exporter protein (LysE YggA)
AOC04_RS01650	COG0583	DNA-binding transcription factor activity
AOC04_RS01655	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AOC04_RS01660	COG2204	response regulator
AOC04_RS01665	COG4191	Histidine kinase
AOC04_RS01680	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOC04_RS01695	COG2076	Multidrug Resistance protein
AOC04_RS01725	COG1126	abc transporter atp-binding protein
AOC04_RS01730	COG0765	amino acid transport
AOC04_RS01735	COG0765	amino acid transport
AOC04_RS01755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOC04_RS01765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOC04_RS01770	COG3842	ATPase activity
AOC04_RS01775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOC04_RS01780	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOC04_RS01790	COG0450	alkyl hydroperoxide reductase
AOC04_RS01795	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOC04_RS01800	COG0418	dihydroorotase activity
AOC04_RS01810	COG0137	argininosuccinate synthase activity
AOC04_RS01815	COG2197	response regulator
AOC04_RS01825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOC04_RS01830	COG2878	Part of a membrane complex involved in electron transport
AOC04_RS01835	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOC04_RS01835	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOC04_RS01840	COG0489	protein tyrosine kinase activity
AOC04_RS01845	COG1278	Cold shock
AOC04_RS01850	COG0717	Belongs to the dCTP deaminase family
AOC04_RS01860	COG4598	ABC transporter
AOC04_RS01870	COG4160	amino acid transport
AOC04_RS01880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS01885	COG2366	antibiotic biosynthetic process
AOC04_RS01890	COG0625	glutathione transferase activity
AOC04_RS01905	COG3012	SEC-C Motif Domain Protein
AOC04_RS01935	COG1199	ATP-dependent helicase activity
AOC04_RS01945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOC04_RS01960	COG0259	pyridoxamine-phosphate oxidase activity
AOC04_RS01970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOC04_RS01975	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AOC04_RS01990	COG0583	DNA-binding transcription factor activity
AOC04_RS02005	COG3220	belongs to the UPF0276 family
AOC04_RS02050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOC04_RS02065	COG0306	phosphate transporter
AOC04_RS02075	COG1414	Transcriptional regulator
AOC04_RS02080	COG2814	Major facilitator Superfamily
AOC04_RS02085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOC04_RS02090	COG0183	Belongs to the thiolase family
AOC04_RS02095	COG0477	Major facilitator Superfamily
AOC04_RS02105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOC04_RS02110	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOC04_RS02125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS02130	COG1309	transcriptional regulator
AOC04_RS02150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AOC04_RS02165	COG1546	Belongs to the CinA family
AOC04_RS02170	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOC04_RS02175	COG2137	regulation of response to DNA damage stimulus
AOC04_RS02190	COG3148	PFAM DTW domain containing protein
AOC04_RS02205	COG0583	DNA-binding transcription factor activity
AOC04_RS02220	COG4807	Protein conserved in bacteria
AOC04_RS02225	COG1187	pseudouridine synthase activity
AOC04_RS02230	COG0519	Catalyzes the synthesis of GMP from XMP
AOC04_RS02235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOC04_RS02240	COG3158	transport of potassium into the cell
AOC04_RS02270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOC04_RS02280	COG0442	prolyl-tRNA aminoacylation
AOC04_RS02285	COG2211	Major facilitator Superfamily
AOC04_RS02290	COG3695	enzyme binding
AOC04_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS02310	COG3030	protein affecting phage T7 exclusion by the F plasmid
AOC04_RS02315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOC04_RS02320	COG0459	protein refolding
AOC04_RS02325	COG1368	sulfuric ester hydrolase activity
AOC04_RS02335	COG0642	Histidine kinase
AOC04_RS02345	COG3642	lipopolysaccharide core region biosynthetic process
AOC04_RS02380	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOC04_RS02395	COG0583	DNA-binding transcription factor activity
AOC04_RS02400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC04_RS02425	COG0583	DNA-binding transcription factor activity
AOC04_RS02435	COG2910	NAD(P)H-binding
AOC04_RS02440	COG0583	DNA-binding transcription factor activity
AOC04_RS02450	COG2207	Transcriptional regulator
AOC04_RS02480	COG0477	Major facilitator Superfamily
AOC04_RS02490	COG4191	Histidine kinase
AOC04_RS02510	COG1301	dicarboxylic acid transport
AOC04_RS02515	COG3091	SprT-like family
AOC04_RS02525	COG0037	tRNA processing
AOC04_RS02530	COG2818	Glycosylase
AOC04_RS02545	COG1393	Belongs to the ArsC family
AOC04_RS02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOC04_RS02565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOC04_RS02570	COG5002	protein histidine kinase activity
AOC04_RS02570	COG2205	protein histidine kinase activity
AOC04_RS02570	COG0784	Response regulator, receiver
AOC04_RS02590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOC04_RS02595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOC04_RS02600	COG3956	TIGRFAM MazG family protein
AOC04_RS02605	COG3122	Protein conserved in bacteria
AOC04_RS02620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOC04_RS02625	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOC04_RS02635	COG0628	permease
AOC04_RS02640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOC04_RS02645	COG0791	NLP P60 protein
AOC04_RS02650	COG0791	NLP P60 protein
AOC04_RS02665	COG1797	cobyrinic acid a,c-diamide synthase activity
AOC04_RS02670	COG0778	Nitroreductase
AOC04_RS02685	COG1492	cobalamin metabolic process
AOC04_RS02695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AOC04_RS02705	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AOC04_RS02750	COG2205	protein histidine kinase activity
AOC04_RS02765	COG2076	Multidrug Resistance protein
AOC04_RS02770	COG0385	Bile acid
AOC04_RS02775	COG2974	May be involved in recombination
AOC04_RS02810	COG1595	DNA-templated transcription, initiation
AOC04_RS02835	COG4067	protein conserved in archaea
AOC04_RS02835	COG0189	ligase activity
AOC04_RS02840	COG1802	Transcriptional regulator
AOC04_RS02850	COG0372	Belongs to the citrate synthase family
AOC04_RS02865	COG0469	pyruvate kinase activity
AOC04_RS02880	COG2925	Exonuclease
AOC04_RS02925	COG0653	protein targeting
AOC04_RS02930	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOC04_RS02940	COG0494	nUDIX hydrolase
AOC04_RS02990	COG1595	DNA-templated transcription, initiation
AOC04_RS03000	COG4176	ABC-type proline glycine betaine transport system permease component
AOC04_RS03005	COG4175	Glycine betaine
AOC04_RS03010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOC04_RS03025	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS03030	COG0625	glutathione transferase activity
AOC04_RS03035	COG1131	(ABC) transporter
AOC04_RS03040	COG0842	Transport permease protein
AOC04_RS03050	COG2333	competence protein COMEC
AOC04_RS03050	COG0658	competence protein
AOC04_RS03055	COG0811	peptide transport
AOC04_RS03060	COG0848	biopolymer transport protein
AOC04_RS03065	COG1663	tetraacyldisaccharide 4'-kinase activity
AOC04_RS03070	COG2835	tetraacyldisaccharide 4'-kinase activity
AOC04_RS03075	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AOC04_RS03080	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOC04_RS03085	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOC04_RS03095	COG1530	ribonuclease E activity
AOC04_RS03105	COG0546	phosphoglycolate phosphatase activity
AOC04_RS03110	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOC04_RS03110	COG0616	signal peptide processing
AOC04_RS03115	COG0424	maF-like protein
AOC04_RS03125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOC04_RS03130	COG0416	fatty acid biosynthetic process
AOC04_RS03145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOC04_RS03150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOC04_RS03160	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOC04_RS03165	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOC04_RS03175	COG0084	hydrolase, TatD family'
AOC04_RS03185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AOC04_RS03190	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS03195	COG1879	ABC-type sugar transport system periplasmic component
AOC04_RS03200	COG1129	ABC transporter
AOC04_RS03205	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC04_RS03220	COG3734	2-keto-3-deoxy-galactonokinase
AOC04_RS03225	COG0800	Aldolase
AOC04_RS03230	COG4948	Mandelate Racemase Muconate Lactonizing
AOC04_RS03235	COG2271	Major facilitator Superfamily
AOC04_RS03240	COG1414	Transcriptional regulator
AOC04_RS03245	COG1064	alcohol dehydrogenase
AOC04_RS03250	COG2207	Transcriptional regulator
AOC04_RS03280	COG2885	chlorophyll binding
AOC04_RS03280	COG3047	cAMP biosynthetic process
AOC04_RS03285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS03315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOC04_RS03315	COG0519	Catalyzes the synthesis of GMP from XMP
AOC04_RS03320	COG0598	Magnesium transport protein CorA
AOC04_RS03325	COG0204	Acyl-transferase
AOC04_RS03410	COG3541	Predicted nucleotidyltransferase
AOC04_RS03480	COG1335	isochorismatase
AOC04_RS03485	COG0583	DNA-binding transcription factor activity
AOC04_RS03530	COG2814	Major facilitator Superfamily
AOC04_RS03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOC04_RS03565	COG0583	DNA-binding transcription factor activity
AOC04_RS03575	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AOC04_RS03590	COG3384	dioxygenase
AOC04_RS03595	COG0500	methyltransferase
AOC04_RS03600	COG0501	Belongs to the peptidase M48B family
AOC04_RS03605	COG0436	Aminotransferase
AOC04_RS03610	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOC04_RS03615	COG0386	Belongs to the glutathione peroxidase family
AOC04_RS03620	COG0784	Response regulator, receiver
AOC04_RS03620	COG2205	protein histidine kinase activity
AOC04_RS03620	COG5002	protein histidine kinase activity
AOC04_RS03630	COG1956	GAF domain-containing protein
AOC04_RS03635	COG3437	response regulator, receiver
AOC04_RS03640	COG2205	protein histidine kinase activity
AOC04_RS03640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS03645	COG2197	response regulator
AOC04_RS03680	COG0564	pseudouridine synthase activity
AOC04_RS03690	COG0746	molybdenum cofactor guanylyltransferase activity
AOC04_RS03695	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOC04_RS03700	COG0303	'Molybdopterin
AOC04_RS03710	COG1597	lipid kinase activity
AOC04_RS03715	COG0835	chemotaxis
AOC04_RS03725	COG0741	lytic transglycosylase activity
AOC04_RS03730	COG0488	(ABC) transporter
AOC04_RS03735	COG0589	response to stress
AOC04_RS03745	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC04_RS03745	COG1024	Enoyl-CoA hydratase
AOC04_RS03750	COG0183	Belongs to the thiolase family
AOC04_RS03795	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOC04_RS03800	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOC04_RS03820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOC04_RS03825	COG0584	glycerophosphoryl diester phosphodiesterase
AOC04_RS03835	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOC04_RS03840	COG1136	(ABC) transporter
AOC04_RS03845	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOC04_RS03865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOC04_RS03865	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOC04_RS03870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOC04_RS03880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOC04_RS03885	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AOC04_RS03890	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AOC04_RS03895	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOC04_RS04050	COG0024	Methionine aminopeptidase
AOC04_RS04075	COG0028	Belongs to the TPP enzyme family
AOC04_RS04085	COG0174	glutamine synthetase
AOC04_RS04105	COG3100	YcgL domain-containing protein
AOC04_RS04120	COG2983	Belongs to the UPF0260 family
AOC04_RS04135	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AOC04_RS04145	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AOC04_RS04150	COG2205	protein histidine kinase activity
AOC04_RS04195	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOC04_RS04215	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AOC04_RS04220	COG4181	ATPase activity
AOC04_RS04235	COG1376	ErfK ybiS ycfS ynhG family protein
AOC04_RS04285	COG0753	catalase activity
AOC04_RS04290	COG2010	Cytochrome c
AOC04_RS04360	COG0668	transmembrane transport
AOC04_RS04370	COG1362	aminopeptidase activity
AOC04_RS04375	COG0564	pseudouridine synthase activity
AOC04_RS04380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AOC04_RS04385	COG2894	cell division
AOC04_RS04390	COG0850	regulation of cytokinetic process
AOC04_RS04395	COG1560	Kdo2-lipid A biosynthetic process
AOC04_RS04405	COG2853	Lipoprotein
AOC04_RS04425	COG2113	Glycine betaine
AOC04_RS04430	COG3162	membrane
AOC04_RS04435	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOC04_RS04445	COG2009	succinate dehydrogenase
AOC04_RS04450	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOC04_RS04455	COG1053	succinate dehydrogenase
AOC04_RS04460	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOC04_RS04475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOC04_RS04480	COG0045	succinate-CoA ligase (ADP-forming) activity
AOC04_RS04500	COG0326	Molecular chaperone. Has ATPase activity
AOC04_RS04510	COG0826	peptidase U32
AOC04_RS04535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
AOC04_RS04545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC04_RS04555	COG0628	permease
AOC04_RS04565	COG1007	ATP synthesis coupled electron transport
AOC04_RS04580	COG0713	ATP synthesis coupled electron transport
AOC04_RS04590	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOC04_RS04595	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AOC04_RS04600	COG1034	ATP synthesis coupled electron transport
AOC04_RS04615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOC04_RS04615	COG0649	NAD binding
AOC04_RS04620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOC04_RS04625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOC04_RS04640	COG2153	protein acetylation
AOC04_RS04645	COG2850	peptidyl-arginine hydroxylation
AOC04_RS04655	COG2915	High frequency lysogenization protein hflD homolog
AOC04_RS04660	COG0482	sulfurtransferase activity
AOC04_RS04675	COG1278	Cold shock
AOC04_RS04680	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOC04_RS04685	COG0542	response to heat
AOC04_RS04690	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOC04_RS04695	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AOC04_RS04700	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOC04_RS04705	COG1674	ftsk spoiiie
AOC04_RS04710	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AOC04_RS04715	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AOC04_RS04720	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOC04_RS04725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOC04_RS04730	COG1648	precorrin-2 dehydrogenase activity
AOC04_RS04730	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOC04_RS04740	COG0189	ligase activity
AOC04_RS04740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOC04_RS04745	COG0367	asparagine synthase
AOC04_RS04755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS04755	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AOC04_RS04760	COG2326	polyphosphate kinase activity
AOC04_RS04765	COG0114	fumarate hydratase activity
AOC04_RS04775	COG0271	Belongs to the BolA IbaG family
AOC04_RS04780	COG1054	Belongs to the UPF0176 family
AOC04_RS04795	COG5001	Diguanylate cyclase
AOC04_RS04795	COG5002	protein histidine kinase activity
AOC04_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS04810	COG0546	phosphoglycolate phosphatase activity
AOC04_RS04815	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOC04_RS04820	COG0402	S-adenosylhomocysteine deaminase activity
AOC04_RS04825	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AOC04_RS04835	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AOC04_RS04845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOC04_RS04850	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOC04_RS04855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AOC04_RS04865	COG0776	regulation of translation
AOC04_RS04885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AOC04_RS04910	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOC04_RS04920	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC04_RS04925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOC04_RS04935	COG1555	photosystem II stabilization
AOC04_RS04945	COG0284	orotidine-5'-phosphate decarboxylase activity
AOC04_RS04950	COG2130	NADP-dependent
AOC04_RS04960	COG3135	benzoate transporter
AOC04_RS04965	COG1802	Transcriptional regulator
AOC04_RS04970	COG0402	S-adenosylhomocysteine deaminase activity
AOC04_RS04985	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AOC04_RS05000	COG3115	cell septum assembly
AOC04_RS05005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOC04_RS05015	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOC04_RS05020	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AOC04_RS05025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOC04_RS05030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOC04_RS05035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOC04_RS05070	COG0348	domain, Protein
AOC04_RS05075	COG2010	Cytochrome c
AOC04_RS05090	COG3278	Belongs to the heme-copper respiratory oxidase family
AOC04_RS05110	COG3278	Belongs to the heme-copper respiratory oxidase family
AOC04_RS05120	COG0840	transmembrane signaling receptor activity
AOC04_RS05135	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AOC04_RS05140	COG0425	Belongs to the sulfur carrier protein TusA family
AOC04_RS05150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOC04_RS05165	COG3123	guanosine phosphorylase activity
AOC04_RS05190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOC04_RS05205	COG0642	Histidine kinase
AOC04_RS05210	COG1113	amino acid transport
AOC04_RS05220	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOC04_RS05225	COG1121	(ABC) transporter
AOC04_RS05265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOC04_RS05270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOC04_RS05300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOC04_RS05310	COG1686	Belongs to the peptidase S11 family
AOC04_RS05315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOC04_RS05320	COG0783	Belongs to the Dps family
AOC04_RS05325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AOC04_RS05345	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC04_RS05350	COG3132	Protein of unknown function, DUF480
AOC04_RS05355	COG2271	Major facilitator Superfamily
AOC04_RS05365	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AOC04_RS05375	COG0583	DNA-binding transcription factor activity
AOC04_RS05385	COG1253	flavin adenine dinucleotide binding
AOC04_RS05395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS05410	COG2207	Transcriptional regulator
AOC04_RS05470	COG1215	transferase activity, transferring glycosyl groups
AOC04_RS05475	COG1215	transferase activity, transferring glycosyl groups
AOC04_RS05480	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOC04_RS05485	COG0457	Tetratricopeptide repeat
AOC04_RS05520	COG1309	transcriptional regulator
AOC04_RS05540	COG0745	RESPONSE REGULATOR receiver
AOC04_RS05545	COG2205	protein histidine kinase activity
AOC04_RS05555	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS05560	COG2721	sulfolactate sulfo-lyase activity
AOC04_RS05565	COG2271	Major facilitator Superfamily
AOC04_RS05580	COG1309	transcriptional regulator
AOC04_RS05610	COG2011	ABC-type metal ion transport system permease component
AOC04_RS05620	COG2226	methyltransferase
AOC04_RS05625	COG0667	Aldo Keto reductase
AOC04_RS05645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS05650	COG4172	Belongs to the ABC transporter superfamily
AOC04_RS05665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS05680	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS05705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AOC04_RS05725	COG0745	RESPONSE REGULATOR receiver
AOC04_RS05730	COG0642	Histidine kinase
AOC04_RS05755	COG3568	Endonuclease Exonuclease Phosphatase
AOC04_RS05795	COG1640	4-alpha-glucanotransferase
AOC04_RS05800	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AOC04_RS05805	COG0297	glycogen (starch) synthase activity
AOC04_RS05825	COG1418	mRNA catabolic process
AOC04_RS05835	COG0814	amino acid
AOC04_RS05840	COG1595	DNA-templated transcription, initiation
AOC04_RS05860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOC04_RS05870	COG3278	Belongs to the heme-copper respiratory oxidase family
AOC04_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS05910	COG1538	Outer membrane efflux protein
AOC04_RS05915	COG2199	diguanylate cyclase activity
AOC04_RS05915	COG2203	Gaf domain
AOC04_RS05940	COG3718	enzyme involved in inositol metabolism
AOC04_RS05950	COG3962	Belongs to the TPP enzyme family
AOC04_RS05955	COG0673	inositol 2-dehydrogenase activity
AOC04_RS05960	COG0673	inositol 2-dehydrogenase activity
AOC04_RS05970	COG1129	ABC transporter
AOC04_RS05975	COG4211	Belongs to the binding-protein-dependent transport system permease family
AOC04_RS05985	COG2384	SAM-dependent methyltransferase
AOC04_RS05995	COG2188	Transcriptional regulator
AOC04_RS06005	COG3284	Transcriptional regulator
AOC04_RS06010	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06075	COG0604	alcohol dehydrogenase
AOC04_RS06075	COG3321	synthase
AOC04_RS06080	COG0583	DNA-binding transcription factor activity
AOC04_RS06090	COG3733	amine oxidase
AOC04_RS06115	COG0583	DNA-binding transcription factor activity
AOC04_RS06150	COG1621	beta-fructofuranosidase activity
AOC04_RS06160	COG0625	glutathione transferase activity
AOC04_RS06180	COG1737	Transcriptional regulator
AOC04_RS06185	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AOC04_RS06190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOC04_RS06200	COG0800	Aldolase
AOC04_RS06205	COG2140	Oxalate decarboxylase
AOC04_RS06210	COG4213	ABC transporter substrate-binding protein
AOC04_RS06215	COG1129	ABC transporter
AOC04_RS06220	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC04_RS06230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOC04_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06240	COG0371	Dehydrogenase
AOC04_RS06245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOC04_RS06250	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06275	COG2391	methyltransferase activity
AOC04_RS06305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOC04_RS06310	COG3209	COG3209 Rhs family protein
AOC04_RS06360	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06365	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06370	COG1024	Enoyl-CoA hydratase
AOC04_RS06375	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06380	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06385	COG0183	Belongs to the thiolase family
AOC04_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06405	COG0183	Belongs to the thiolase family
AOC04_RS06410	COG0534	Mate efflux family protein
AOC04_RS06435	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06450	COG0659	secondary active sulfate transmembrane transporter activity
AOC04_RS06460	COG0701	Predicted permease
AOC04_RS06505	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AOC04_RS06510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOC04_RS06520	COG0183	Belongs to the thiolase family
AOC04_RS06525	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06530	COG1024	Enoyl-CoA hydratase
AOC04_RS06535	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS06540	COG1024	Enoyl-CoA hydratase
AOC04_RS06545	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOC04_RS06555	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOC04_RS06560	COG2197	response regulator
AOC04_RS06600	COG0477	Major facilitator Superfamily
AOC04_RS06605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC04_RS06610	COG0583	DNA-binding transcription factor activity
AOC04_RS06625	COG2271	Major facilitator Superfamily
AOC04_RS06630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOC04_RS06660	COG2814	Major facilitator Superfamily
AOC04_RS06665	COG3485	protocatechuate 3,4-dioxygenase
AOC04_RS06670	COG3135	benzoate transporter
AOC04_RS06680	COG3193	protein, possibly involved in utilization of glycolate and propanediol
AOC04_RS06685	COG0247	lactate metabolic process
AOC04_RS06690	COG0277	FAD linked oxidase domain protein
AOC04_RS06695	COG0277	FAD linked oxidase domain protein
AOC04_RS06710	COG0786	glutamate:sodium symporter activity
AOC04_RS06725	COG0642	Histidine kinase
AOC04_RS06765	COG3829	transcription factor binding
AOC04_RS06775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC04_RS06780	COG0431	NADPH-dependent FMN reductase
AOC04_RS06800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC04_RS06820	COG1124	(ABC) transporter
AOC04_RS06825	COG0444	Belongs to the ABC transporter superfamily
AOC04_RS06830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS06835	COG0601	transmembrane transport
AOC04_RS06845	COG0864	Transcriptional regulator
AOC04_RS06850	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS06860	COG3209	COG3209 Rhs family protein
AOC04_RS06920	COG1408	metallophosphoesterase
AOC04_RS06925	COG2814	Major facilitator Superfamily
AOC04_RS06930	COG1971	Probably functions as a manganese efflux pump
AOC04_RS06935	COG2197	response regulator
AOC04_RS06945	COG1879	ABC-type sugar transport system periplasmic component
AOC04_RS06950	COG1129	ABC transporter
AOC04_RS06965	COG3386	PFAM SMP-30 Gluconolaconase
AOC04_RS06975	COG1238	metal cluster binding
AOC04_RS07010	COG0477	Major facilitator Superfamily
AOC04_RS07020	COG4521	taurine ABC transporter
AOC04_RS07030	COG0768	penicillin binding
AOC04_RS07040	COG3038	cytochrome b561
AOC04_RS07050	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOC04_RS07055	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOC04_RS07065	COG3139	Protein of unknown function (DUF1315)
AOC04_RS07075	COG0308	aminopeptidase N
AOC04_RS07080	COG1609	Transcriptional regulator
AOC04_RS07100	COG2706	6-phosphogluconolactonase activity
AOC04_RS07135	COG0420	3'-5' exonuclease activity
AOC04_RS07165	COG0714	Associated with various cellular activities
AOC04_RS07200	COG4566	intracellular signal transduction
AOC04_RS07210	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOC04_RS07245	COG3081	Nucleoid-associated protein
AOC04_RS07305	COG0583	DNA-binding transcription factor activity
AOC04_RS07540	COG3179	chitinase
AOC04_RS07560	COG2135	peptidase activity
AOC04_RS07565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOC04_RS07570	COG1309	transcriptional regulator
AOC04_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS07605	COG4993	Dehydrogenase
AOC04_RS07620	COG1396	sequence-specific DNA binding
AOC04_RS07630	COG0019	diaminopimelate decarboxylase activity
AOC04_RS07660	COG1301	dicarboxylic acid transport
AOC04_RS07665	COG2814	Major facilitator Superfamily
AOC04_RS07685	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOC04_RS07690	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOC04_RS07730	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS07735	COG1609	Transcriptional regulator
AOC04_RS07740	COG1177	transmembrane transport
AOC04_RS07745	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOC04_RS07750	COG3842	ATPase activity
AOC04_RS07755	COG0174	glutamine synthetase
AOC04_RS07760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS07765	COG1396	sequence-specific DNA binding
AOC04_RS07765	COG1917	Cupin 2, conserved barrel domain protein
AOC04_RS07770	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOC04_RS07785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOC04_RS07795	COG1942	4-Oxalocrotonate Tautomerase
AOC04_RS07830	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOC04_RS07835	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AOC04_RS07850	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOC04_RS07855	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS07865	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS07900	COG3209	COG3209 Rhs family protein
AOC04_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS07920	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS07935	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS07940	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS07975	COG2814	Major facilitator Superfamily
AOC04_RS07980	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS07995	COG1902	pentaerythritol trinitrate reductase activity
AOC04_RS08000	COG0318	PFAM AMP-dependent synthetase and ligase
AOC04_RS08025	COG0346	lactoylglutathione lyase activity
AOC04_RS08040	COG1024	Enoyl-CoA hydratase
AOC04_RS08045	COG2070	2-Nitropropane dioxygenase
AOC04_RS08055	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS08075	COG0616	signal peptide processing
AOC04_RS08085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOC04_RS08105	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AOC04_RS08105	COG0316	Belongs to the HesB IscA family
AOC04_RS08140	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AOC04_RS08150	COG0784	Response regulator, receiver
AOC04_RS08150	COG2198	Histidine kinase
AOC04_RS08150	COG2205	protein histidine kinase activity
AOC04_RS08185	COG0596	Alpha beta hydrolase
AOC04_RS08225	COG0626	cystathionine gamma-synthase activity
AOC04_RS08255	COG2814	Major facilitator Superfamily
AOC04_RS08275	COG1132	(ABC) transporter
AOC04_RS08275	COG2375	cellular response to nickel ion
AOC04_RS08280	COG1132	(ABC) transporter
AOC04_RS08285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC04_RS08290	COG4605	iron ion homeostasis
AOC04_RS08295	COG4604	ABC transporter, ATP-binding protein
AOC04_RS08300	COG4607	ABC-type enterochelin transport system periplasmic component
AOC04_RS08305	COG4774	siderophore transport
AOC04_RS08310	COG0583	DNA-binding transcription factor activity
AOC04_RS08320	COG4166	transmembrane transport
AOC04_RS08330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS08335	COG4172	Belongs to the ABC transporter superfamily
AOC04_RS08350	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AOC04_RS08360	COG2814	Major facilitator Superfamily
AOC04_RS08390	COG0251	oxidation-reduction process
AOC04_RS08400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOC04_RS08420	COG1070	Carbohydrate kinase
AOC04_RS08425	COG0246	Mannitol dehydrogenase
AOC04_RS08440	COG1175	transmembrane transport
AOC04_RS08490	COG2204	response regulator
AOC04_RS08550	COG2076	Multidrug Resistance protein
AOC04_RS08555	COG2076	Multidrug Resistance protein
AOC04_RS08560	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AOC04_RS08565	COG0726	polysaccharide deacetylase
AOC04_RS08570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOC04_RS08570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC04_RS08575	COG0463	Glycosyl transferase, family 2
AOC04_RS08580	COG2822	iron ion transport
AOC04_RS08595	COG0672	)-iron permease
AOC04_RS08615	COG3634	alkyl hydroperoxide reductase activity
AOC04_RS08630	COG2200	EAL domain
AOC04_RS08645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS08650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS08655	COG0745	RESPONSE REGULATOR receiver
AOC04_RS08670	COG2962	Rard protein
AOC04_RS08675	COG2271	Major facilitator Superfamily
AOC04_RS08680	COG3835	regulator
AOC04_RS08685	COG1929	Belongs to the glycerate kinase type-1 family
AOC04_RS08690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC04_RS08695	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AOC04_RS08700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AOC04_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS08735	COG0583	DNA-binding transcription factor activity
AOC04_RS08755	COG2080	2 iron, 2 sulfur cluster binding
AOC04_RS08760	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AOC04_RS08765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOC04_RS08780	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AOC04_RS08785	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AOC04_RS08800	COG3121	Chaperone
AOC04_RS08805	COG3188	usher protein
AOC04_RS08825	COG2207	Transcriptional regulator
AOC04_RS08840	COG4702	Belongs to the UPF0303 family
AOC04_RS08845	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AOC04_RS08850	COG3622	Belongs to the hyi family
AOC04_RS08865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS08905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOC04_RS08910	COG2200	EAL domain
AOC04_RS08935	COG0583	DNA-binding transcription factor activity
AOC04_RS08940	COG1288	antiporter activity
AOC04_RS08950	COG3046	protein related to deoxyribodipyrimidine photolyase
AOC04_RS08975	COG1253	flavin adenine dinucleotide binding
AOC04_RS08985	COG0583	DNA-binding transcription factor activity
AOC04_RS09010	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS09040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
AOC04_RS09070	COG2194	sulfuric ester hydrolase activity
AOC04_RS09090	COG1215	transferase activity, transferring glycosyl groups
AOC04_RS09095	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
AOC04_RS09100	COG3118	belongs to the thioredoxin family
AOC04_RS09100	COG0457	Tetratricopeptide repeat
AOC04_RS09155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AOC04_RS09175	COG0113	porphobilinogen synthase activity
AOC04_RS09180	COG0640	Transcriptional regulator
AOC04_RS09185	COG1063	alcohol dehydrogenase
AOC04_RS09190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOC04_RS09210	COG2133	pyrroloquinoline quinone binding
AOC04_RS09225	COG1063	alcohol dehydrogenase
AOC04_RS09250	COG1802	Transcriptional regulator
AOC04_RS09280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS09325	COG0596	Alpha beta hydrolase
AOC04_RS09335	COG0488	(ABC) transporter
AOC04_RS09350	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOC04_RS09355	COG0583	DNA-binding transcription factor activity
AOC04_RS09370	COG1968	undecaprenyl-diphosphatase activity
AOC04_RS09375	COG0840	transmembrane signaling receptor activity
AOC04_RS09385	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AOC04_RS09410	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AOC04_RS09415	COG1609	Transcriptional regulator
AOC04_RS09425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOC04_RS09450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS09465	COG0210	DNA helicase
AOC04_RS09480	COG2814	Major facilitator Superfamily
AOC04_RS09485	COG0583	DNA-binding transcription factor activity
AOC04_RS09495	COG0586	Pfam SNARE associated Golgi protein
AOC04_RS09500	COG0697	spore germination
AOC04_RS09515	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOC04_RS09515	COG3008	intermembrane lipid transfer
AOC04_RS09525	COG2995	paraquat-inducible protein a
AOC04_RS09550	COG0405	Gamma-glutamyltransferase
AOC04_RS09555	COG2011	ABC-type metal ion transport system permease component
AOC04_RS09560	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOC04_RS09590	COG0747	negative chemotaxis
AOC04_RS09595	COG4608	Belongs to the ABC transporter superfamily
AOC04_RS09600	COG0444	Belongs to the ABC transporter superfamily
AOC04_RS09605	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS09615	COG2072	flavoprotein involved in K transport
AOC04_RS09645	COG2186	Transcriptional regulator
AOC04_RS09650	COG1473	amidohydrolase
AOC04_RS09655	COG1285	pathogenesis
AOC04_RS09670	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOC04_RS09695	COG0626	cystathionine gamma-synthase activity
AOC04_RS09700	COG2706	6-phosphogluconolactonase activity
AOC04_RS09710	COG0789	Transcriptional regulator
AOC04_RS09730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOC04_RS09735	COG0489	protein tyrosine kinase activity
AOC04_RS09735	COG3206	protein involved in exopolysaccharide biosynthesis
AOC04_RS09740	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AOC04_RS09745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOC04_RS09760	COG0438	transferase activity, transferring glycosyl groups
AOC04_RS09765	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
AOC04_RS09785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOC04_RS09815	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOC04_RS09825	COG2353	YceI-like domain
AOC04_RS09840	COG1252	NADH dehydrogenase
AOC04_RS09845	COG1959	2 iron, 2 sulfur cluster binding
AOC04_RS09865	COG2111	Na H antiporter
AOC04_RS09865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AOC04_RS09870	COG1006	Multisubunit Na H antiporter MnhC subunit
AOC04_RS09875	COG0651	ATP synthesis coupled electron transport
AOC04_RS09885	COG2212	antiporter activity
AOC04_RS09890	COG1320	monovalent cation:proton antiporter activity
AOC04_RS09895	COG0471	metal ion transport
AOC04_RS09925	COG5001	Diguanylate cyclase
AOC04_RS09925	COG3447	MASE1 domain protein
AOC04_RS09925	COG5002	protein histidine kinase activity
AOC04_RS09960	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS09965	COG1126	abc transporter atp-binding protein
AOC04_RS09970	COG0477	Major facilitator Superfamily
AOC04_RS09975	COG0583	DNA-binding transcription factor activity
AOC04_RS09980	COG1902	pentaerythritol trinitrate reductase activity
AOC04_RS09980	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOC04_RS10030	COG1286	toxin biosynthetic process
AOC04_RS10040	COG0285	dihydrofolate synthase activity
AOC04_RS10045	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOC04_RS10050	COG0135	phosphoribosylanthranilate isomerase activity
AOC04_RS10075	COG0473	3-isopropylmalate dehydrogenase activity
AOC04_RS10080	COG2226	methyltransferase
AOC04_RS10085	COG0066	3-isopropylmalate dehydratase activity
AOC04_RS10090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AOC04_RS10105	COG0183	Belongs to the thiolase family
AOC04_RS10120	COG3387	PFAM Glycoside hydrolase 15-related
AOC04_RS10125	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS10130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS10135	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOC04_RS10140	COG3383	formate dehydrogenase (NAD+) activity
AOC04_RS10155	COG4774	siderophore transport
AOC04_RS10165	COG1595	DNA-templated transcription, initiation
AOC04_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS10180	COG0583	DNA-binding transcription factor activity
AOC04_RS10200	COG1132	(ABC) transporter
AOC04_RS10220	COG4206	TonB-dependent receptor
AOC04_RS10225	COG4166	transmembrane transport
AOC04_RS10230	COG4174	ABC transporter (Permease)
AOC04_RS10235	COG4239	(ABC) transporter, permease
AOC04_RS10240	COG4172	Belongs to the ABC transporter superfamily
AOC04_RS10245	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOC04_RS10255	COG0765	amino acid transport
AOC04_RS10290	COG5642	Protein of unknown function (DUF2384)
AOC04_RS10310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS10320	COG4993	Dehydrogenase
AOC04_RS10340	COG3318	Belongs to the UPF0149 family
AOC04_RS10340	COG3012	SEC-C Motif Domain Protein
AOC04_RS10355	COG0579	oxidoreductase
AOC04_RS10370	COG4191	Histidine kinase
AOC04_RS10370	COG0784	Response regulator, receiver
AOC04_RS10380	COG0583	DNA-binding transcription factor activity
AOC04_RS10385	COG0277	FAD linked oxidase domain protein
AOC04_RS10385	COG0247	lactate metabolic process
AOC04_RS10405	COG3842	ATPase activity
AOC04_RS10410	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOC04_RS10415	COG1177	transmembrane transport
AOC04_RS10420	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOC04_RS10425	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AOC04_RS10430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC04_RS10435	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS10440	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOC04_RS10460	COG0765	amino acid transport
AOC04_RS10470	COG0583	DNA-binding transcription factor activity
AOC04_RS10490	COG0556	nucleotide-excision repair
AOC04_RS10500	COG2223	nitrite transmembrane transporter activity
AOC04_RS10505	COG4772	TonB-dependent receptor
AOC04_RS10515	COG1595	DNA-templated transcription, initiation
AOC04_RS10520	COG1120	ATPase activity
AOC04_RS10535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOC04_RS10565	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
AOC04_RS10575	COG4607	ABC-type enterochelin transport system periplasmic component
AOC04_RS10580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC04_RS10590	COG4774	siderophore transport
AOC04_RS10600	COG0477	Major facilitator Superfamily
AOC04_RS10620	COG0583	DNA-binding transcription factor activity
AOC04_RS10625	COG1289	transmembrane transporter activity
AOC04_RS10635	COG0832	Belongs to the urease beta subunit family
AOC04_RS10640	COG0804	urea catabolic process
AOC04_RS10655	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AOC04_RS10665	COG4413	Urea transporter
AOC04_RS10675	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOC04_RS10695	COG0417	DNA replication proofreading
AOC04_RS10720	COG0714	Associated with various cellular activities
AOC04_RS10740	COG2304	oxidoreductase activity
AOC04_RS10755	COG3119	arylsulfatase activity
AOC04_RS10765	COG0484	heat shock protein binding
AOC04_RS10785	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS10800	COG0154	amidase activity
AOC04_RS10815	COG1953	Uracil, thiamine, allantoin
AOC04_RS10835	COG1309	transcriptional regulator
AOC04_RS10845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOC04_RS10855	COG0393	Putative heavy-metal-binding
AOC04_RS10860	COG1611	Belongs to the LOG family
AOC04_RS10870	COG1522	sequence-specific DNA binding
AOC04_RS10895	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AOC04_RS10915	COG0626	cystathionine gamma-synthase activity
AOC04_RS10920	COG1522	sequence-specific DNA binding
AOC04_RS10940	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOC04_RS11080	COG3246	L-lysine catabolic process to acetate
AOC04_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS11090	COG1802	Transcriptional regulator
AOC04_RS11100	COG1126	abc transporter atp-binding protein
AOC04_RS11105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS11125	COG2271	Major facilitator Superfamily
AOC04_RS11170	COG0583	DNA-binding transcription factor activity
AOC04_RS11175	COG0477	Major facilitator Superfamily
AOC04_RS11180	COG0235	Class ii aldolase
AOC04_RS11185	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOC04_RS11195	COG0477	Major facilitator Superfamily
AOC04_RS11200	COG0251	oxidation-reduction process
AOC04_RS11205	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOC04_RS11215	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC04_RS11265	COG1473	amidohydrolase
AOC04_RS11270	COG0583	DNA-binding transcription factor activity
AOC04_RS11295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOC04_RS11315	COG4638	Rieske (2fe-2S)
AOC04_RS11335	COG0154	amidase activity
AOC04_RS11350	COG0411	ABC transporter
AOC04_RS11365	COG3485	protocatechuate 3,4-dioxygenase
AOC04_RS11370	COG4829	muconolactone delta-isomerase
AOC04_RS11375	COG4948	Mandelate Racemase Muconate Lactonizing
AOC04_RS11415	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
AOC04_RS11450	COG3179	chitinase
AOC04_RS11550	COG0740	serine-type endopeptidase activity
AOC04_RS11665	COG0776	regulation of translation
AOC04_RS11670	COG0072	phenylalanine-tRNA ligase activity
AOC04_RS11675	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOC04_RS11680	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOC04_RS11685	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOC04_RS11690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AOC04_RS11695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AOC04_RS11705	COG1278	Cold shock
AOC04_RS11730	COG1869	D-ribose catabolic process
AOC04_RS11735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOC04_RS11740	COG1609	Transcriptional regulator
AOC04_RS11745	COG1172	Belongs to the binding-protein-dependent transport system permease family
AOC04_RS11750	COG1129	ABC transporter
AOC04_RS11755	COG1879	ABC-type sugar transport system periplasmic component
AOC04_RS11805	COG1522	sequence-specific DNA binding
AOC04_RS11810	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOC04_RS11815	COG0022	dehydrogenase e1 component
AOC04_RS11825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOC04_RS11830	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOC04_RS11835	COG2233	PERMEase
AOC04_RS11845	COG1124	(ABC) transporter
AOC04_RS11850	COG0444	Belongs to the ABC transporter superfamily
AOC04_RS11855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOC04_RS11865	COG0747	negative chemotaxis
AOC04_RS11880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS11885	COG0697	spore germination
AOC04_RS11890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC04_RS11900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOC04_RS11910	COG2358	TRAP transporter, solute receptor (TAXI family
AOC04_RS11965	COG0406	alpha-ribazole phosphatase activity
AOC04_RS11975	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
AOC04_RS12030	COG4297	protein containing double-stranded beta helix domain
AOC04_RS12045	COG4221	oxidoreductase activity
AOC04_RS12080	COG0028	Belongs to the TPP enzyme family
AOC04_RS12085	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS12100	COG3729	General stress protein
AOC04_RS12115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AOC04_RS12130	COG2323	membrane
AOC04_RS12170	COG1546	Belongs to the CinA family
AOC04_RS12170	COG1058	Belongs to the CinA family
AOC04_RS12180	COG4191	Histidine kinase
AOC04_RS12180	COG0784	Response regulator, receiver
AOC04_RS12190	COG3685	Protein conserved in bacteria
AOC04_RS12245	COG2920	part of a sulfur-relay system
AOC04_RS12250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOC04_RS12255	COG0435	Glutathione S-transferase
AOC04_RS12260	COG3089	Belongs to the UPF0270 family
AOC04_RS12265	COG1742	UPF0060 membrane protein
AOC04_RS12270	COG1368	sulfuric ester hydrolase activity
AOC04_RS12295	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AOC04_RS12305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AOC04_RS12310	COG1073	alpha beta
AOC04_RS12335	COG2840	Smr protein MutS2
AOC04_RS12340	COG0302	gtp cyclohydrolase
AOC04_RS12350	COG0625	glutathione transferase activity
AOC04_RS12355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS12365	COG2252	PERMEase
AOC04_RS12390	COG4266	Belongs to the allantoicase family
AOC04_RS12395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AOC04_RS12405	COG2233	PERMEase
AOC04_RS12420	COG1309	transcriptional regulator
AOC04_RS12430	COG2354	Protein conserved in bacteria
AOC04_RS12435	COG1309	transcriptional regulator
AOC04_RS12445	COG3960	tartronate-semialdehyde synthase activity
AOC04_RS12450	COG3622	Belongs to the hyi family
AOC04_RS12455	COG2084	Dehydrogenase
AOC04_RS12460	COG4413	Urea transporter
AOC04_RS12465	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOC04_RS12475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AOC04_RS12480	COG0384	phenazine biosynthesis protein PhzF
AOC04_RS12490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOC04_RS12505	COG3088	subunit of a heme lyase
AOC04_RS12515	COG1138	Cytochrome C-type biogenesis protein
AOC04_RS12540	COG4133	protoheme IX ABC transporter activity
AOC04_RS12560	COG0835	chemotaxis
AOC04_RS12570	COG1192	Involved in chromosome partitioning
AOC04_RS12580	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AOC04_RS12585	COG2201	protein-glutamate methylesterase activity
AOC04_RS12590	COG0643	Histidine kinase
AOC04_RS12590	COG2198	Histidine kinase
AOC04_RS12590	COG0784	Response regulator, receiver
AOC04_RS12595	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AOC04_RS12670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOC04_RS12685	COG0745	RESPONSE REGULATOR receiver
AOC04_RS12720	COG1677	Flagellar hook-basal body complex protein FliE
AOC04_RS12750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AOC04_RS12775	COG4786	Flagellar basal body rod
AOC04_RS12775	COG1256	bacterial-type flagellum assembly
AOC04_RS12785	COG1706	bacterial-type flagellum-dependent cell motility
AOC04_RS12790	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AOC04_RS12800	COG4787	bacterial-type flagellum-dependent cell motility
AOC04_RS12815	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOC04_RS12835	COG1113	amino acid transport
AOC04_RS12850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOC04_RS12860	COG0009	L-threonylcarbamoyladenylate synthase
AOC04_RS12865	COG0613	PHP domain protein
AOC04_RS12870	COG2917	probably involved in intracellular septation
AOC04_RS12875	COG2350	Protein conserved in bacteria
AOC04_RS12880	COG0745	RESPONSE REGULATOR receiver
AOC04_RS12890	COG0642	Histidine kinase
AOC04_RS12895	COG0778	Nitroreductase
AOC04_RS12900	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOC04_RS12905	COG2207	Transcriptional regulator
AOC04_RS12920	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOC04_RS12930	COG0514	ATP-dependent DNA helicase (RecQ)
AOC04_RS12940	COG2832	Protein of unknown function (DUF454)
AOC04_RS12970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOC04_RS12975	COG0583	DNA-binding transcription factor activity
AOC04_RS12985	COG0697	spore germination
AOC04_RS12995	COG2996	Protein conserved in bacteria
AOC04_RS13015	COG0513	Belongs to the DEAD box helicase family
AOC04_RS13020	COG0668	transmembrane transport
AOC04_RS13025	COG3710	Transcriptional regulator
AOC04_RS13050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AOC04_RS13065	COG1132	(ABC) transporter
AOC04_RS13070	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AOC04_RS13080	COG2188	Transcriptional regulator
AOC04_RS13100	COG1643	Atp-dependent helicase
AOC04_RS13110	COG1104	cysteine desulfurase activity
AOC04_RS13135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOC04_RS13145	COG0542	response to heat
AOC04_RS13155	COG1984	allophanate hydrolase subunit 2
AOC04_RS13160	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AOC04_RS13165	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AOC04_RS13175	COG0121	glutamine amidotransferase
AOC04_RS13185	COG1770	oligopeptidase
AOC04_RS13200	COG1605	Chorismate mutase
AOC04_RS13200	COG0287	Prephenate dehydrogenase
AOC04_RS13205	COG0628	permease
AOC04_RS13230	COG2062	phosphohistidine phosphatase, SixA
AOC04_RS13240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOC04_RS13245	COG5002	protein histidine kinase activity
AOC04_RS13245	COG2205	protein histidine kinase activity
AOC04_RS13245	COG0784	Response regulator, receiver
AOC04_RS13250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOC04_RS13270	COG1741	Belongs to the pirin family
AOC04_RS13275	COG2056	Na+-H+ antiporter family
AOC04_RS13280	COG0840	transmembrane signaling receptor activity
AOC04_RS13300	COG0720	synthase
AOC04_RS13330	COG5006	permease, DMT superfamily
AOC04_RS13345	COG3829	transcription factor binding
AOC04_RS13350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC04_RS13360	COG2816	NAD+ diphosphatase activity
AOC04_RS13365	COG1024	Enoyl-CoA hydratase
AOC04_RS13370	COG0561	phosphatase activity
AOC04_RS13375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AOC04_RS13380	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AOC04_RS13385	COG2194	sulfuric ester hydrolase activity
AOC04_RS13405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
AOC04_RS13420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS13425	COG0577	efflux transmembrane transporter activity
AOC04_RS13425	COG1136	(ABC) transporter
AOC04_RS13435	COG0656	L-ascorbic acid biosynthetic process
AOC04_RS13440	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOC04_RS13480	COG0583	DNA-binding transcription factor activity
AOC04_RS13485	COG0667	Aldo Keto reductase
AOC04_RS13490	COG2911	Protein conserved in bacteria
AOC04_RS13505	COG0708	Exodeoxyribonuclease III
AOC04_RS13510	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOC04_RS13525	COG0789	Transcriptional regulator
AOC04_RS13535	COG0318	PFAM AMP-dependent synthetase and ligase
AOC04_RS13540	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS13545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOC04_RS13550	COG1024	Enoyl-CoA hydratase
AOC04_RS13575	COG1522	sequence-specific DNA binding
AOC04_RS13580	COG2866	Carboxypeptidase
AOC04_RS13590	COG0217	transcriptional regulatory protein
AOC04_RS13595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS13605	COG0583	DNA-binding transcription factor activity
AOC04_RS13610	COG0583	DNA-binding transcription factor activity
AOC04_RS13615	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AOC04_RS13620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AOC04_RS13625	COG0431	NADPH-dependent FMN reductase
AOC04_RS13645	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOC04_RS13650	COG0328	RNA-DNA hybrid ribonuclease activity
AOC04_RS13660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOC04_RS13665	COG1388	LysM domain
AOC04_RS13665	COG0741	lytic transglycosylase activity
AOC04_RS13670	COG4166	transmembrane transport
AOC04_RS13675	COG4166	transmembrane transport
AOC04_RS13680	COG4174	ABC transporter (Permease)
AOC04_RS13685	COG4239	(ABC) transporter, permease
AOC04_RS13690	COG4172	Belongs to the ABC transporter superfamily
AOC04_RS13710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOC04_RS13715	COG0776	regulation of translation
AOC04_RS13720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AOC04_RS13725	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOC04_RS13730	COG0740	serine-type endopeptidase activity
AOC04_RS13735	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOC04_RS13760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AOC04_RS13765	COG0215	cysteine-tRNA ligase activity
AOC04_RS13770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOC04_RS13780	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOC04_RS13785	COG2814	Major facilitator Superfamily
AOC04_RS13790	COG1566	PFAM secretion protein HlyD family protein
AOC04_RS13800	COG1846	Transcriptional regulator
AOC04_RS13810	COG0589	response to stress
AOC04_RS13830	COG0425	Belongs to the sulfur carrier protein TusA family
AOC04_RS13840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AOC04_RS13880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOC04_RS13885	COG0602	queuosine metabolic process
AOC04_RS13890	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
AOC04_RS13895	COG2885	chlorophyll binding
AOC04_RS13900	COG0823	Involved in the tonB-independent uptake of proteins
AOC04_RS13920	COG0824	Thioesterase
AOC04_RS13925	COG2255	four-way junction helicase activity
AOC04_RS13930	COG0632	four-way junction helicase activity
AOC04_RS13935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AOC04_RS13940	COG0217	transcriptional regulatory protein
AOC04_RS13945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOC04_RS13960	COG2900	Belongs to the SlyX family
AOC04_RS13975	COG0668	transmembrane transport
AOC04_RS13980	COG1666	GTP binding
AOC04_RS13995	COG2096	Adenosyltransferase
AOC04_RS14000	COG3171	Protein conserved in bacteria
AOC04_RS14005	COG2027	D-alanyl-D-alanine carboxypeptidase
AOC04_RS14010	COG0116	Belongs to the methyltransferase superfamily
AOC04_RS14010	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOC04_RS14015	COG0167	dihydroorotate dehydrogenase activity
AOC04_RS14020	COG3047	cAMP biosynthetic process
AOC04_RS14020	COG2885	chlorophyll binding
AOC04_RS14030	COG0668	transmembrane transport
AOC04_RS14045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOC04_RS14060	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AOC04_RS14080	COG1454	alcohol dehydrogenase
AOC04_RS14090	COG3422	double-strand break repair
AOC04_RS14105	COG1629	transport
AOC04_RS14115	COG0693	protein deglycase activity
AOC04_RS14130	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
AOC04_RS14135	COG1704	LemA family
AOC04_RS14145	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOC04_RS14145	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOC04_RS14150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOC04_RS14160	COG0402	S-adenosylhomocysteine deaminase activity
AOC04_RS14175	COG1558	bacterial-type flagellum-dependent cell motility
AOC04_RS14180	COG1815	bacterial-type flagellum-dependent cell motility
AOC04_RS14185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AOC04_RS14190	COG0784	Response regulator, receiver
AOC04_RS14190	COG0835	chemotaxis
AOC04_RS14210	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AOC04_RS14215	COG0477	Major facilitator Superfamily
AOC04_RS14230	COG0483	inositol monophosphate 1-phosphatase activity
AOC04_RS14255	COG0583	DNA-binding transcription factor activity
AOC04_RS14260	COG1053	succinate dehydrogenase
AOC04_RS14280	COG2186	Transcriptional regulator
AOC04_RS14285	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS14295	COG4948	Mandelate Racemase Muconate Lactonizing
AOC04_RS14305	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS14310	COG3254	rhamnose metabolic process
AOC04_RS14315	COG0738	Major facilitator superfamily
AOC04_RS14320	COG2271	Major facilitator Superfamily
AOC04_RS14325	COG2271	Major facilitator Superfamily
AOC04_RS14330	COG0583	DNA-binding transcription factor activity
AOC04_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS14345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC04_RS14355	COG2084	Dehydrogenase
AOC04_RS14360	COG0129	dihydroxy-acid dehydratase activity
AOC04_RS14370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOC04_RS14380	COG1953	Uracil, thiamine, allantoin
AOC04_RS14395	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
AOC04_RS14405	COG2239	Acts as a magnesium transporter
AOC04_RS14430	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOC04_RS14435	COG0527	aspartate kinase activity
AOC04_RS14440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOC04_RS14445	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AOC04_RS14450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOC04_RS14455	COG2988	succinylglutamate desuccinylase activity
AOC04_RS14465	COG3724	N-succinylarginine dihydrolase activity
AOC04_RS14470	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS14485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOC04_RS14525	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOC04_RS14540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOC04_RS14555	COG3706	GGDEF domain
AOC04_RS14570	COG0584	glycerophosphoryl diester phosphodiesterase
AOC04_RS14600	COG0436	Aminotransferase
AOC04_RS14610	COG3265	gluconokinase activity
AOC04_RS14615	COG1609	Transcriptional regulator
AOC04_RS14620	COG2271	Major facilitator Superfamily
AOC04_RS14635	COG0242	peptide deformylase activity
AOC04_RS14640	COG1295	ribonuclease BN
AOC04_RS14645	COG3237	CsbD-like
AOC04_RS14655	COG0318	PFAM AMP-dependent synthetase and ligase
AOC04_RS14660	COG0318	PFAM AMP-dependent synthetase and ligase
AOC04_RS14670	COG2030	dehydratase
AOC04_RS14680	COG3530	Putative quorum-sensing-regulated virulence factor
AOC04_RS14685	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOC04_RS14690	COG0800	Aldolase
AOC04_RS14705	COG1737	Transcriptional regulator
AOC04_RS14710	COG0676	glucose-6-phosphate 1-epimerase activity
AOC04_RS14730	COG1175	transmembrane transport
AOC04_RS14735	COG1653	transport
AOC04_RS14765	COG1803	Methylglyoxal synthase
AOC04_RS14775	COG3712	iron ion homeostasis
AOC04_RS14780	COG4771	TonB-dependent receptor
AOC04_RS14780	COG1629	transport
AOC04_RS14790	COG2832	Protein of unknown function (DUF454)
AOC04_RS14830	COG0509	glycine decarboxylation via glycine cleavage system
AOC04_RS14835	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC04_RS14835	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOC04_RS14840	COG1760	l-serine dehydratase
AOC04_RS14850	COG1278	Cold shock
AOC04_RS14860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOC04_RS14890	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOC04_RS14895	COG0354	folic acid binding
AOC04_RS14935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AOC04_RS14955	COG2267	carboxylic ester hydrolase activity
AOC04_RS14970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC04_RS15000	COG2814	Major facilitator Superfamily
AOC04_RS15005	COG1902	pentaerythritol trinitrate reductase activity
AOC04_RS15020	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AOC04_RS15025	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AOC04_RS15030	COG0585	pseudouridine synthase activity
AOC04_RS15035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOC04_RS15045	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AOC04_RS15055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOC04_RS15065	COG0148	phosphopyruvate hydratase activity
AOC04_RS15070	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AOC04_RS15075	COG0504	CTP synthase activity
AOC04_RS15080	COG0037	tRNA processing
AOC04_RS15085	COG0825	malonyl-CoA metabolic process
AOC04_RS15090	COG0587	DNA-directed DNA polymerase activity
AOC04_RS15095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOC04_RS15100	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOC04_RS15105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOC04_RS15110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOC04_RS15115	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOC04_RS15125	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOC04_RS15135	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOC04_RS15145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOC04_RS15150	COG0233	cytoplasmic translational termination
AOC04_RS15155	COG0528	UMP kinase activity
AOC04_RS15160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOC04_RS15165	COG0052	Belongs to the universal ribosomal protein uS2 family
AOC04_RS15170	COG0024	Methionine aminopeptidase
AOC04_RS15175	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOC04_RS15180	COG0436	Aminotransferase
AOC04_RS15185	COG0025	NhaP-type Na H and K H
AOC04_RS15190	COG1393	Belongs to the ArsC family
AOC04_RS15195	COG2171	N-acyltransferase activity
AOC04_RS15200	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AOC04_RS15210	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOC04_RS15220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOC04_RS15225	COG2226	methyltransferase
AOC04_RS15240	COG2937	Belongs to the GPAT DAPAT family
AOC04_RS15250	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS15265	COG0742	ribosomal rna small subunit methyltransferase
AOC04_RS15275	COG1801	Protein of unknown function DUF72
AOC04_RS15285	COG1214	PFAM Peptidase M22, glycoprotease
AOC04_RS15290	COG0563	adenylate kinase activity
AOC04_RS15295	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOC04_RS15305	COG2885	chlorophyll binding
AOC04_RS15315	COG1073	alpha beta
AOC04_RS15335	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOC04_RS15340	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AOC04_RS15345	COG5001	Diguanylate cyclase
AOC04_RS15345	COG4251	negative regulation of phosphorylation
AOC04_RS15345	COG3706	GGDEF domain
AOC04_RS15345	COG2203	Gaf domain
AOC04_RS15350	COG2201	protein-glutamate methylesterase activity
AOC04_RS15360	COG0835	chemotaxis
AOC04_RS15370	COG0835	chemotaxis
AOC04_RS15385	COG1902	pentaerythritol trinitrate reductase activity
AOC04_RS15400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOC04_RS15425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOC04_RS15430	COG4974	Belongs to the 'phage' integrase family
AOC04_RS15440	COG1607	acyl-coa hydrolase
AOC04_RS15445	COG0335	large ribosomal subunit rRNA binding
AOC04_RS15450	COG0336	Belongs to the RNA methyltransferase TrmD family
AOC04_RS15455	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOC04_RS15460	COG0228	four-way junction DNA binding
AOC04_RS15465	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOC04_RS15475	COG4536	flavin adenine dinucleotide binding
AOC04_RS15480	COG0477	Major facilitator Superfamily
AOC04_RS15485	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AOC04_RS15505	COG0494	nUDIX hydrolase
AOC04_RS15520	COG2188	Transcriptional regulator
AOC04_RS15525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AOC04_RS15530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOC04_RS15535	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
AOC04_RS15535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AOC04_RS15540	COG1263	PTS System
AOC04_RS15540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AOC04_RS15540	COG2190	(PTS) system
AOC04_RS15545	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOC04_RS15550	COG0047	phosphoribosylformylglycinamidine synthase activity
AOC04_RS15550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOC04_RS15555	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOC04_RS15560	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOC04_RS15565	COG1381	Involved in DNA repair and RecF pathway recombination
AOC04_RS15570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOC04_RS15575	COG0571	ribonuclease III activity
AOC04_RS15580	COG0681	Belongs to the peptidase S26 family
AOC04_RS15585	COG0481	GTPase activity
AOC04_RS15590	COG0795	lipopolysaccharide-transporting ATPase activity
AOC04_RS15595	COG0795	lipopolysaccharide-transporting ATPase activity
AOC04_RS15600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AOC04_RS15615	COG0525	valine-tRNA ligase activity
AOC04_RS15620	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AOC04_RS15630	COG3081	Nucleoid-associated protein
AOC04_RS15645	COG2827	Endonuclease containing a URI domain
AOC04_RS15650	COG2807	transmembrane transport
AOC04_RS15660	COG0765	amino acid transport
AOC04_RS15665	COG4597	amino acid ABC transporter
AOC04_RS15670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS15680	COG0400	carboxylic ester hydrolase activity
AOC04_RS15685	COG0513	Belongs to the DEAD box helicase family
AOC04_RS15695	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AOC04_RS15700	COG0315	cyclic pyranopterin monophosphate synthase activity
AOC04_RS15720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS15725	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AOC04_RS15735	COG3022	response to hydroperoxide
AOC04_RS15745	COG1215	transferase activity, transferring glycosyl groups
AOC04_RS15750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS15755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AOC04_RS15765	COG3420	alginic acid biosynthetic process
AOC04_RS15780	COG1696	Membrane protein involved in D-alanine export
AOC04_RS15795	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
AOC04_RS15795	COG0662	Cupin 2, conserved barrel domain protein
AOC04_RS15805	COG0300	oxidoreductase activity
AOC04_RS15825	COG1566	PFAM secretion protein HlyD family protein
AOC04_RS15845	COG0583	DNA-binding transcription factor activity
AOC04_RS15850	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOC04_RS15865	COG4774	siderophore transport
AOC04_RS15895	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOC04_RS15905	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
AOC04_RS15915	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOC04_RS15920	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AOC04_RS15930	COG1346	cytolysis
AOC04_RS15940	COG0583	DNA-binding transcription factor activity
AOC04_RS15950	COG1366	Belongs to the anti-sigma-factor antagonist family
AOC04_RS15975	COG0302	gtp cyclohydrolase
AOC04_RS15980	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOC04_RS15995	COG0492	ferredoxin-NADP+ reductase activity
AOC04_RS16000	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AOC04_RS16010	COG0386	Belongs to the glutathione peroxidase family
AOC04_RS16020	COG0857	belongs to the CobB CobQ family
AOC04_RS16020	COG0280	phosphate acetyltransferase
AOC04_RS16025	COG0204	Acyl-transferase
AOC04_RS16035	COG0175	sulfate reduction
AOC04_RS16045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOC04_RS16050	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOC04_RS16055	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOC04_RS16060	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOC04_RS16065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOC04_RS16085	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AOC04_RS16090	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOC04_RS16095	COG1127	ABC transporter
AOC04_RS16105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOC04_RS16115	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOC04_RS16120	COG1137	ATPase activity
AOC04_RS16125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AOC04_RS16130	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AOC04_RS16140	COG1660	Displays ATPase and GTPase activities
AOC04_RS16175	COG0312	modulator of DNA gyrase
AOC04_RS16180	COG3028	Belongs to the UPF0307 family
AOC04_RS16185	COG0312	modulator of DNA gyrase
AOC04_RS16190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOC04_RS16200	COG1530	ribonuclease E activity
AOC04_RS16205	COG0424	maF-like protein
AOC04_RS16215	COG1792	Involved in formation and maintenance of cell shape
AOC04_RS16220	COG1077	Cell shape determining protein MreB Mrl
AOC04_RS16225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOC04_RS16230	COG0154	amidase activity
AOC04_RS16235	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOC04_RS16240	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOC04_RS16260	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AOC04_RS16265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AOC04_RS16275	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AOC04_RS16280	COG1090	epimerase
AOC04_RS16285	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AOC04_RS16300	COG0789	Transcriptional regulator
AOC04_RS16305	COG0415	Belongs to the DNA photolyase family
AOC04_RS16310	COG4221	oxidoreductase activity
AOC04_RS16325	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOC04_RS16345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOC04_RS16350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AOC04_RS16360	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOC04_RS16365	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AOC04_RS16375	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AOC04_RS16380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOC04_RS16390	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOC04_RS16395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AOC04_RS16400	COG0193	aminoacyl-tRNA hydrolase activity
AOC04_RS16415	COG2223	nitrite transmembrane transporter activity
AOC04_RS16425	COG0277	FAD linked oxidase domain protein
AOC04_RS16430	COG1802	Transcriptional regulator
AOC04_RS16445	COG3121	Chaperone
AOC04_RS16450	COG3188	usher protein
AOC04_RS16470	COG2197	response regulator
AOC04_RS16475	COG2197	response regulator
AOC04_RS16480	COG2203	Gaf domain
AOC04_RS16480	COG2199	diguanylate cyclase activity
AOC04_RS16480	COG2200	EAL domain
AOC04_RS16485	COG2205	protein histidine kinase activity
AOC04_RS16485	COG0784	Response regulator, receiver
AOC04_RS16490	COG2837	iron assimilation
AOC04_RS16500	COG2031	fatty acid transporter
AOC04_RS16505	COG0288	reversible hydration of carbon dioxide
AOC04_RS16515	COG0456	acetyltransferase
AOC04_RS16540	COG3008	intermembrane lipid transfer
AOC04_RS16545	COG2995	paraquat-inducible protein a
AOC04_RS16550	COG2995	paraquat-inducible protein a
AOC04_RS16595	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AOC04_RS16600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AOC04_RS16605	COG1183	phosphatidylcholine synthase activity
AOC04_RS16610	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOC04_RS16620	COG0028	Belongs to the TPP enzyme family
AOC04_RS16625	COG3098	single-species biofilm formation
AOC04_RS16635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOC04_RS16655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AOC04_RS16660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC04_RS16665	COG4558	Periplasmic binding protein
AOC04_RS16675	COG1489	DNA binding
AOC04_RS16680	COG0436	Aminotransferase
AOC04_RS16690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOC04_RS16700	COG4191	Histidine kinase
AOC04_RS16720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOC04_RS16725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AOC04_RS16730	COG0166	Belongs to the GPI family
AOC04_RS16745	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOC04_RS16755	COG2823	Periplasmic or secreted lipoprotein
AOC04_RS16760	COG1185	polyribonucleotide nucleotidyltransferase activity
AOC04_RS16765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOC04_RS16770	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOC04_RS16775	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOC04_RS16780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AOC04_RS16785	COG0195	Participates in both transcription termination and antitermination
AOC04_RS16790	COG0779	Required for maturation of 30S ribosomal subunits
AOC04_RS16805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AOC04_RS16810	COG0149	triose-phosphate isomerase activity
AOC04_RS16815	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOC04_RS16820	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOC04_RS16825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOC04_RS16830	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOC04_RS16840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOC04_RS16845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOC04_RS16850	COG0505	Belongs to the CarA family
AOC04_RS16855	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOC04_RS16860	COG0484	heat shock protein binding
AOC04_RS16865	COG0443	Heat shock 70 kDa protein
AOC04_RS16870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AOC04_RS16875	COG0497	DNA recombination
AOC04_RS16885	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOC04_RS16890	COG2914	Belongs to the UPF0125 (RnfH) family
AOC04_RS16900	COG0733	neurotransmitter:sodium symporter activity
AOC04_RS16905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOC04_RS16915	COG1620	l-lactate permease
AOC04_RS16920	COG0247	lactate metabolic process
AOC04_RS16950	COG1414	Transcriptional regulator
AOC04_RS16965	COG2267	carboxylic ester hydrolase activity
AOC04_RS16985	COG2814	Major facilitator Superfamily
AOC04_RS17005	COG2197	response regulator
AOC04_RS17020	COG0583	DNA-binding transcription factor activity
AOC04_RS17050	COG0028	Belongs to the TPP enzyme family
AOC04_RS17085	COG1914	H( )-stimulated, divalent metal cation uptake system
AOC04_RS17090	COG2721	sulfolactate sulfo-lyase activity
AOC04_RS17095	COG2271	Major facilitator Superfamily
AOC04_RS17100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOC04_RS17120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS17130	COG0174	glutamine synthetase
AOC04_RS17135	COG2207	Transcriptional regulator
AOC04_RS17140	COG1522	sequence-specific DNA binding
AOC04_RS17145	COG1280	lysine exporter protein (LysE YggA)
AOC04_RS17150	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
AOC04_RS17195	COG1358	cellular component organization or biogenesis
AOC04_RS17230	COG0840	transmembrane signaling receptor activity
AOC04_RS17235	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
AOC04_RS17245	COG2610	gluconate transmembrane transporter activity
AOC04_RS17250	COG0659	secondary active sulfate transmembrane transporter activity
AOC04_RS17265	COG0583	DNA-binding transcription factor activity
AOC04_RS17270	COG2249	NAD(P)H dehydrogenase (quinone) activity
AOC04_RS17285	COG1113	amino acid transport
AOC04_RS17305	COG0583	DNA-binding transcription factor activity
AOC04_RS17310	COG0288	reversible hydration of carbon dioxide
AOC04_RS17320	COG2885	chlorophyll binding
AOC04_RS17335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOC04_RS17340	COG1074	ATP-dependent DNA helicase activity
AOC04_RS17345	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOC04_RS17405	COG1309	transcriptional regulator
AOC04_RS17420	COG0387	Pfam Sodium calcium exchanger
AOC04_RS17425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOC04_RS17430	COG0583	DNA-binding transcription factor activity
AOC04_RS17435	COG0604	alcohol dehydrogenase
AOC04_RS17470	COG0640	Transcriptional regulator
AOC04_RS17485	COG2207	Transcriptional regulator
AOC04_RS17495	COG0183	Belongs to the thiolase family
AOC04_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS17515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOC04_RS17585	COG4964	Belongs to the GSP D family
AOC04_RS17615	COG4953	penicillin-binding protein 1C
AOC04_RS17625	COG2373	Large extracellular alpha-helical protein
AOC04_RS17630	COG0534	Mate efflux family protein
AOC04_RS17640	COG1166	arginine decarboxylase activity
AOC04_RS17645	COG0023	Translation Initiation Factor
AOC04_RS17670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AOC04_RS17685	COG2264	protein methyltransferase activity
AOC04_RS17695	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOC04_RS17705	COG0138	bifunctional purine biosynthesis protein purh
AOC04_RS17710	COG0151	Belongs to the GarS family
AOC04_RS17720	COG2095	MarC family integral membrane protein
AOC04_RS17750	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AOC04_RS17800	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOC04_RS17820	COG0411	ABC transporter
AOC04_RS17830	COG0829	nickel cation binding
AOC04_RS17835	COG0831	urea catabolic process
AOC04_RS17850	COG0832	Belongs to the urease beta subunit family
AOC04_RS17855	COG0804	urea catabolic process
AOC04_RS17865	COG0789	Transcriptional regulator
AOC04_RS17870	COG0484	heat shock protein binding
AOC04_RS17875	COG0443	Heat shock 70 kDa protein
AOC04_RS17895	COG0697	spore germination
AOC04_RS17905	COG2982	Protein involved in outer membrane biogenesis
AOC04_RS17920	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AOC04_RS17925	COG0830	nickel cation binding
AOC04_RS17930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AOC04_RS17945	COG4221	oxidoreductase activity
AOC04_RS17975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS17980	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS17985	COG0583	DNA-binding transcription factor activity
AOC04_RS17990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AOC04_RS17995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AOC04_RS18015	COG1032	radical SAM domain protein
AOC04_RS18020	COG0305	Participates in initiation and elongation during chromosome replication
AOC04_RS18025	COG0359	binds to the 23S rRNA
AOC04_RS18035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AOC04_RS18040	COG0360	Binds together with S18 to 16S ribosomal RNA
AOC04_RS18045	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOC04_RS18050	COG0557	exoribonuclease II activity
AOC04_RS18065	COG1840	ABC-type Fe3 transport system, periplasmic component
AOC04_RS18070	COG1178	ABC-type Fe3 transport system permease component
AOC04_RS18075	COG0840	transmembrane signaling receptor activity
AOC04_RS18080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOC04_RS18085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AOC04_RS18090	COG0330	HflC and HflK could
AOC04_RS18095	COG0330	HflC and HflK could
AOC04_RS18100	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOC04_RS18105	COG1923	regulation of RNA biosynthetic process
AOC04_RS18110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AOC04_RS18115	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOC04_RS18120	COG0860	N-Acetylmuramoyl-L-alanine amidase
AOC04_RS18125	COG0802	atpase or kinase
AOC04_RS18130	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOC04_RS18130	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOC04_RS18140	COG2860	membrane
AOC04_RS18145	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOC04_RS18150	COG1162	GTPase activity
AOC04_RS18155	COG1360	Flagellar Motor Protein
AOC04_RS18175	COG0688	phosphatidylethanolamine metabolic process
AOC04_RS18200	COG3577	Aspartyl protease
AOC04_RS18215	COG3150	esterase
AOC04_RS18220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOC04_RS18230	COG0494	nUDIX hydrolase
AOC04_RS18245	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AOC04_RS18250	COG1538	Outer membrane efflux protein
AOC04_RS18255	COG1519	Transferase
AOC04_RS18270	COG0667	Aldo Keto reductase
AOC04_RS18280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AOC04_RS18280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AOC04_RS18285	COG1132	(ABC) transporter
AOC04_RS18300	COG1215	transferase activity, transferring glycosyl groups
AOC04_RS18305	COG0438	transferase activity, transferring glycosyl groups
AOC04_RS18320	COG0438	transferase activity, transferring glycosyl groups
AOC04_RS18325	COG2192	nodulation
AOC04_RS18335	COG4772	TonB-dependent receptor
AOC04_RS18360	COG0438	transferase activity, transferring glycosyl groups
AOC04_RS18365	COG0859	PFAM glycosyl transferase family 9
AOC04_RS18370	COG0859	PFAM glycosyl transferase family 9
AOC04_RS18380	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOC04_RS18400	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOC04_RS18405	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOC04_RS18410	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOC04_RS18415	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOC04_RS18415	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AOC04_RS18415	COG0506	proline dehydrogenase activity
AOC04_RS18425	COG3263	regulation of cellular component size
AOC04_RS18430	COG1196	nuclear chromosome segregation
AOC04_RS18430	COG3264	Mechanosensitive ion channel
AOC04_RS18435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOC04_RS18440	COG3118	belongs to the thioredoxin family
AOC04_RS18445	COG1192	Involved in chromosome partitioning
AOC04_RS18460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOC04_RS18465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AOC04_RS18490	COG2986	histidine ammonia-lyase
AOC04_RS18530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOC04_RS18540	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS18545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOC04_RS18555	COG0583	DNA-binding transcription factor activity
AOC04_RS18560	COG2814	Major facilitator Superfamily
AOC04_RS18625	COG3397	chitin binding
AOC04_RS18630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AOC04_RS18635	COG0493	'glutamate synthase
AOC04_RS18640	COG0070	glutamate synthase
AOC04_RS18640	COG0067	glutamate synthase
AOC04_RS18640	COG0069	glutamate synthase activity
AOC04_RS18650	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AOC04_RS18655	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOC04_RS18695	COG0281	malic enzyme
AOC04_RS18705	COG0254	rRNA binding
AOC04_RS18710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOC04_RS18715	COG0018	arginyl-trna synthetase
AOC04_RS18725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AOC04_RS18730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AOC04_RS18750	COG2226	methyltransferase
AOC04_RS18760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOC04_RS18765	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOC04_RS18770	COG0140	phosphoribosyl-ATP diphosphatase activity
AOC04_RS18775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOC04_RS18780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOC04_RS18795	COG0840	transmembrane signaling receptor activity
AOC04_RS18805	COG0765	amino acid transport
AOC04_RS18815	COG2943	transferase activity, transferring hexosyl groups
AOC04_RS18820	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AOC04_RS18825	COG1490	D-aminoacyl-tRNA deacylase activity
AOC04_RS18830	COG0596	Alpha beta hydrolase
AOC04_RS18840	COG1228	amidohydrolase
AOC04_RS18845	COG1113	amino acid transport
AOC04_RS18850	COG2986	histidine ammonia-lyase
AOC04_RS18855	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AOC04_RS18860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOC04_RS18870	COG2188	Transcriptional regulator
AOC04_RS18875	COG0402	S-adenosylhomocysteine deaminase activity
AOC04_RS18880	COG0514	ATP-dependent DNA helicase (RecQ)
AOC04_RS18895	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AOC04_RS18900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOC04_RS18905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOC04_RS18910	COG4067	protein conserved in archaea
AOC04_RS18910	COG0189	ligase activity
AOC04_RS18915	COG0189	ligase activity
AOC04_RS18930	COG2183	response to ionizing radiation
AOC04_RS18940	COG2918	glutathione biosynthetic process
AOC04_RS18945	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOC04_RS18945	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOC04_RS18970	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AOC04_RS18975	COG0058	SHG alpha-glucan phosphorylase activity
AOC04_RS18985	COG1217	gtp-binding protein TYPA
AOC04_RS18990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOC04_RS18990	COG0301	tRNA thio-modification
AOC04_RS19005	COG3852	Histidine kinase
AOC04_RS19025	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOC04_RS19040	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOC04_RS19050	COG0793	Belongs to the peptidase S41A family
AOC04_RS19055	COG2861	carbohydrate metabolic process
AOC04_RS19065	COG0107	imidazoleglycerol-phosphate synthase activity
AOC04_RS19070	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOC04_RS19080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOC04_RS19085	COG0131	Imidazoleglycerol-phosphate dehydratase
AOC04_RS19090	COG2223	nitrite transmembrane transporter activity
AOC04_RS19100	COG1194	a g-specific adenine glycosylase
AOC04_RS19105	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AOC04_RS19125	COG0431	NADPH-dependent FMN reductase
AOC04_RS19130	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOC04_RS19140	COG0640	Transcriptional regulator
AOC04_RS19145	COG3813	Protein conserved in bacteria
AOC04_RS19155	COG4251	negative regulation of phosphorylation
AOC04_RS19160	COG0786	glutamate:sodium symporter activity
AOC04_RS19165	COG0010	Belongs to the arginase family
AOC04_RS19190	COG4215	(ABC) transporter
AOC04_RS19240	COG2610	gluconate transmembrane transporter activity
AOC04_RS19245	COG3048	D-serine ammonia-lyase activity
AOC04_RS19250	COG0583	DNA-binding transcription factor activity
AOC04_RS19275	COG2957	Belongs to the agmatine deiminase family
AOC04_RS19305	COG1218	3'(2'),5'-bisphosphate nucleotidase
AOC04_RS19310	COG0494	nUDIX hydrolase
AOC04_RS19315	COG1011	Hydrolase
AOC04_RS19320	COG1652	LysM domain
AOC04_RS19330	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AOC04_RS19350	COG1522	sequence-specific DNA binding
AOC04_RS19360	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOC04_RS19365	COG0330	HflC and HflK could
AOC04_RS19380	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOC04_RS19385	COG0509	glycine decarboxylation via glycine cleavage system
AOC04_RS19390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AOC04_RS19395	COG1178	ABC-type Fe3 transport system permease component
AOC04_RS19405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOC04_RS19410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOC04_RS19415	COG0006	proline dipeptidase activity
AOC04_RS19420	COG3079	Belongs to the UPF0149 family
AOC04_RS19440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOC04_RS19450	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS19455	COG0842	Transport permease protein
AOC04_RS19455	COG1129	ABC transporter
AOC04_RS19460	COG0842	Transport permease protein
AOC04_RS19470	COG2271	Major facilitator Superfamily
AOC04_RS19500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AOC04_RS19520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS19525	COG0765	amino acid transport
AOC04_RS19530	COG0765	amino acid transport
AOC04_RS19535	COG1126	abc transporter atp-binding protein
AOC04_RS19540	COG0248	Ppx GppA phosphatase
AOC04_RS19545	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AOC04_RS19550	COG0586	Pfam SNARE associated Golgi protein
AOC04_RS19560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AOC04_RS19565	COG1671	Belongs to the UPF0178 family
AOC04_RS19570	COG0672	)-iron permease
AOC04_RS19575	COG1280	lysine exporter protein (LysE YggA)
AOC04_RS19585	COG0488	(ABC) transporter
AOC04_RS19610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOC04_RS19630	COG0181	hydroxymethylbilane synthase activity
AOC04_RS19640	COG0165	Argininosuccinate lyase
AOC04_RS19645	COG0625	glutathione transferase activity
AOC04_RS19670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOC04_RS19675	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS19685	COG0494	nUDIX hydrolase
AOC04_RS19710	COG1566	PFAM secretion protein HlyD family protein
AOC04_RS19720	COG1289	transmembrane transporter activity
AOC04_RS19740	COG1802	Transcriptional regulator
AOC04_RS19745	COG0840	transmembrane signaling receptor activity
AOC04_RS19795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOC04_RS19800	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS19805	COG0583	DNA-binding transcription factor activity
AOC04_RS19825	COG0427	acetyl-CoA hydrolase
AOC04_RS19890	COG0704	Plays a role in the regulation of phosphate uptake
AOC04_RS19895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOC04_RS19900	COG0573	inorganic phosphate transmembrane transporter activity
AOC04_RS19915	COG0477	Major facilitator Superfamily
AOC04_RS19920	COG1607	acyl-coa hydrolase
AOC04_RS19950	COG0583	DNA-binding transcription factor activity
AOC04_RS19955	COG1027	Aspartate ammonia-lyase
AOC04_RS19960	COG1115	amino acid carrier protein
AOC04_RS19965	COG0252	asparaginase activity
AOC04_RS20010	COG5016	pyruvate
AOC04_RS20010	COG0511	ligase activity, forming carbon-carbon bonds
AOC04_RS20015	COG0439	Biotin carboxylase
AOC04_RS20020	COG0583	DNA-binding transcription factor activity
AOC04_RS20035	COG0210	DNA helicase
AOC04_RS20050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AOC04_RS20050	COG4651	solute:proton antiporter activity
AOC04_RS20055	COG1607	acyl-coa hydrolase
AOC04_RS20060	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AOC04_RS20070	COG0523	cobalamin synthesis protein
AOC04_RS20085	COG1469	GTP cyclohydrolase I activity
AOC04_RS20090	COG4451	ribulose bisphosphate carboxylase, small
AOC04_RS20090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOC04_RS20100	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC04_RS20105	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOC04_RS20110	COG2217	Heavy metal translocating P-type atpase
AOC04_RS20140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOC04_RS20145	COG1349	DNA-binding transcription factor activity
AOC04_RS20150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOC04_RS20155	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOC04_RS20160	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOC04_RS20165	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOC04_RS20170	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOC04_RS20175	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOC04_RS20180	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOC04_RS20190	COG0356	it plays a direct role in the translocation of protons across the membrane
AOC04_RS20195	COG3312	ion transport
AOC04_RS20200	COG1475	DNA binding
AOC04_RS20205	COG1192	Involved in chromosome partitioning
AOC04_RS20210	COG0357	Ribosomal RNA small subunit methyltransferase G
AOC04_RS20215	COG0445	tRNA wobble uridine modification
AOC04_RS20220	COG0488	(ABC) transporter
AOC04_RS20225	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AOC04_RS20230	COG0706	membrane insertase activity
AOC04_RS20235	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AOC04_RS20240	COG0594	ribonuclease P activity
AOC04_RS20245	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AOC04_RS20250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AOC04_RS20255	COG0592	DNA-directed DNA polymerase activity
AOC04_RS20260	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AOC04_RS20265	COG0187	DNA topoisomerase II activity
AOC04_RS20285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AOC04_RS20290	COG0751	glycine-tRNA ligase activity
AOC04_RS20295	COG0752	glycyl-tRNA synthetase alpha subunit
AOC04_RS20300	COG2818	Glycosylase
AOC04_RS20315	COG0569	domain protein
AOC04_RS20320	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AOC04_RS20325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOC04_RS20330	COG0242	peptide deformylase activity
AOC04_RS20335	COG0758	DNA mediated transformation
AOC04_RS20340	COG0009	L-threonylcarbamoyladenylate synthase
AOC04_RS20350	COG0408	coproporphyrinogen oxidase activity
AOC04_RS20355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOC04_RS20365	COG3119	arylsulfatase activity
AOC04_RS20380	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOC04_RS20385	COG1028	Short-chain dehydrogenase reductase Sdr
AOC04_RS20390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOC04_RS20395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOC04_RS20420	COG3829	transcription factor binding
AOC04_RS20440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AOC04_RS20445	COG0339	signal peptide processing
AOC04_RS20450	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AOC04_RS20455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AOC04_RS20460	COG4208	sulfate ABC transporter
AOC04_RS20470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOC04_RS20485	COG3072	Adenylate cyclase
AOC04_RS20490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOC04_RS20495	COG1965	Belongs to the frataxin family
AOC04_RS20500	COG0019	diaminopimelate decarboxylase activity
AOC04_RS20505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOC04_RS20515	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOC04_RS20520	COG1011	Hydrolase
AOC04_RS20530	COG0004	ammonium transporteR
AOC04_RS20535	COG0347	Belongs to the P(II) protein family
AOC04_RS20550	COG0606	chelatase, subunit chli
AOC04_RS20555	COG0583	DNA-binding transcription factor activity
AOC04_RS20560	COG0534	Mate efflux family protein
AOC04_RS20575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOC04_RS20580	COG0427	acetyl-CoA hydrolase
AOC04_RS20595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOC04_RS20605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS20620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOC04_RS20630	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOC04_RS20635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOC04_RS20645	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS20655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOC04_RS20660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOC04_RS20665	COG0747	negative chemotaxis
AOC04_RS20670	COG2003	Belongs to the UPF0758 family
AOC04_RS20675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOC04_RS20680	COG0756	dUTP diphosphatase activity
AOC04_RS20685	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOC04_RS20690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOC04_RS20695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AOC04_RS20700	COG0708	Exodeoxyribonuclease III
AOC04_RS20710	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOC04_RS20715	COG1561	YicC-like family, N-terminal region
AOC04_RS20720	COG0194	GDP metabolic process
AOC04_RS20725	COG1758	RNA polymerase activity
AOC04_RS20730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOC04_RS20755	COG0848	biopolymer transport protein
AOC04_RS20765	COG0583	DNA-binding transcription factor activity
AOC04_RS20770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOC04_RS20800	COG3161	chorismate lyase activity
AOC04_RS20805	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOC04_RS20835	COG1683	Conserved Protein
AOC04_RS20850	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AOC04_RS20860	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AOC04_RS20880	COG1612	heme a metabolic process
AOC04_RS20885	COG0109	protoheme IX farnesyltransferase activity
AOC04_RS20900	COG2011	ABC-type metal ion transport system permease component
AOC04_RS20905	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOC04_RS20920	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOC04_RS20925	COG1121	(ABC) transporter
AOC04_RS20930	COG0735	belongs to the Fur family
AOC04_RS20935	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
AOC04_RS20955	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOC04_RS20970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AOC04_RS20985	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOC04_RS20990	COG5002	protein histidine kinase activity
AOC04_RS20995	COG2204	response regulator
AOC04_RS21010	COG1301	dicarboxylic acid transport
AOC04_RS21015	COG0700	Nucleoside recognition
AOC04_RS21030	COG1127	ABC transporter
AOC04_RS21035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AOC04_RS21045	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOC04_RS21050	COG0277	FAD linked oxidase domain protein
AOC04_RS21055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOC04_RS21065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS21105	COG1764	response to oxidative stress
AOC04_RS21110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC04_RS21120	COG3360	Dodecin
AOC04_RS21135	COG0133	tryptophan synthase activity
AOC04_RS21140	COG0159	tryptophan synthase activity
AOC04_RS21145	COG1045	serine acetyltransferase
AOC04_RS21150	COG0612	Peptidase, M16
AOC04_RS21160	COG2851	Citrate transporter
AOC04_RS21165	COG1253	flavin adenine dinucleotide binding
AOC04_RS21185	COG1177	transmembrane transport
AOC04_RS21190	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOC04_RS21195	COG3842	ATPase activity
AOC04_RS21215	COG0174	glutamine synthetase
AOC04_RS21220	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AOC04_RS21225	COG0174	glutamine synthetase
AOC04_RS21235	COG2175	clavaminate synthase activity
AOC04_RS21240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOC04_RS21245	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AOC04_RS21250	COG4521	taurine ABC transporter
AOC04_RS21260	COG0450	alkyl hydroperoxide reductase
AOC04_RS21265	COG0431	NADPH-dependent FMN reductase
AOC04_RS21270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOC04_RS21275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOC04_RS21280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AOC04_RS21285	COG1116	anion transmembrane transporter activity
AOC04_RS21300	COG2226	methyltransferase
AOC04_RS21305	COG2011	ABC-type metal ion transport system permease component
AOC04_RS21310	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOC04_RS21340	COG3204	pilus organization
AOC04_RS21345	COG3204	pilus organization
AOC04_RS21350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AOC04_RS21355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AOC04_RS21370	COG0494	nUDIX hydrolase
AOC04_RS21385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AOC04_RS21390	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOC04_RS21395	COG0789	Transcriptional regulator
AOC04_RS21405	COG0583	DNA-binding transcription factor activity
AOC04_RS21410	COG3842	ATPase activity
AOC04_RS21415	COG1178	ABC-type Fe3 transport system permease component
AOC04_RS21420	COG1840	ABC-type Fe3 transport system, periplasmic component
AOC04_RS21435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AOC04_RS21450	COG1823	symporter activity
AOC04_RS21460	COG0129	dihydroxy-acid dehydratase activity
AOC04_RS21465	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
AOC04_RS21470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOC04_RS21480	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOC04_RS21485	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOC04_RS21490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AOC04_RS21495	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AOC04_RS21530	COG0742	ribosomal rna small subunit methyltransferase
AOC04_RS21535	COG0612	Peptidase, M16
AOC04_RS21540	COG0612	Peptidase, M16
AOC04_RS21545	COG0552	protein localization to endoplasmic reticulum
AOC04_RS21550	COG2884	Cell division ATP-binding protein ftsE
AOC04_RS21555	COG2177	Part of the ABC transporter FtsEX involved in
AOC04_RS21565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOC04_RS21570	COG2363	Small membrane protein
AOC04_RS21580	COG2022	thiamine diphosphate biosynthetic process
AOC04_RS21585	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOC04_RS21595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOC04_RS21600	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AOC04_RS21610	COG2813	Specifically methylates the guanine in position
AOC04_RS21610	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOC04_RS21615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOC04_RS21620	COG1872	DUF167
AOC04_RS21645	COG0791	NLP P60 protein
AOC04_RS21655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AOC04_RS21660	COG0540	Belongs to the ATCase OTCase family
AOC04_RS21665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AOC04_RS21670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOC04_RS21675	COG1678	Uncharacterized ACR, COG1678
AOC04_RS21685	COG0189	ligase activity
AOC04_RS21720	COG1272	protein, Hemolysin III
AOC04_RS21725	COG2116	formate transmembrane transporter activity
AOC04_RS21735	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOC04_RS21740	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOC04_RS21745	COG0513	Belongs to the DEAD box helicase family
AOC04_RS21750	COG2353	YceI-like domain
AOC04_RS21755	COG3038	cytochrome b561
AOC04_RS21765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOC04_RS21770	COG4977	sequence-specific DNA binding
AOC04_RS21785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOC04_RS21790	COG0251	oxidation-reduction process
AOC04_RS21805	COG4993	Dehydrogenase
AOC04_RS21840	COG1422	Protein of unknown function (DUF1090)
AOC04_RS21845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOC04_RS21850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOC04_RS21860	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOC04_RS21865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AOC04_RS21870	COG0126	phosphoglycerate kinase activity
AOC04_RS21895	COG1451	nucleotide metabolic process
AOC04_RS21905	COG2153	protein acetylation
AOC04_RS21910	COG1289	transmembrane transporter activity
AOC04_RS21915	COG2081	HI0933 family
AOC04_RS21920	COG0513	Belongs to the DEAD box helicase family
AOC04_RS21925	COG0477	Major facilitator Superfamily
AOC04_RS21940	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AOC04_RS21945	COG1012	belongs to the aldehyde dehydrogenase family
AOC04_RS21950	COG1309	transcriptional regulator
AOC04_RS21955	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOC04_RS21960	COG4175	Glycine betaine
AOC04_RS21965	COG4176	ABC-type proline glycine betaine transport system permease component
AOC04_RS21975	COG1760	l-serine dehydratase
AOC04_RS21995	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOC04_RS22000	COG3246	L-lysine catabolic process to acetate
AOC04_RS22035	COG1902	pentaerythritol trinitrate reductase activity
AOC04_RS22035	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOC04_RS22040	COG2181	nitrate reductase activity
AOC04_RS22040	COG0247	lactate metabolic process
AOC04_RS22045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AOC04_RS22055	COG4638	Rieske (2fe-2S)
AOC04_RS22060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AOC04_RS22080	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOC04_RS22110	COG1063	alcohol dehydrogenase
AOC04_RS22125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AOC04_RS22140	COG0189	ligase activity
AOC04_RS22140	COG4067	protein conserved in archaea
AOC04_RS22150	COG4774	siderophore transport
AOC04_RS22160	COG1595	DNA-templated transcription, initiation
AOC04_RS22165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOC04_RS22180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AOC04_RS22195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOC04_RS22205	COG3585	molybdate ion transport
AOC04_RS22205	COG2005	Transcriptional regulator
AOC04_RS22215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOC04_RS22220	COG0156	8-amino-7-oxononanoate synthase activity
AOC04_RS22225	COG2226	methyltransferase
AOC04_RS22225	COG1073	alpha beta
AOC04_RS22240	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS22245	COG1960	acyl-CoA dehydrogenase activity
AOC04_RS22250	COG0583	DNA-binding transcription factor activity
AOC04_RS22255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOC04_RS22265	COG0535	radical SAM domain protein
AOC04_RS22275	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
AOC04_RS22280	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AOC04_RS22285	COG1025	Belongs to the peptidase M16 family
AOC04_RS22290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOC04_RS22320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AOC04_RS22325	COG0358	DNA primase activity
AOC04_RS22330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOC04_RS22335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOC04_RS22340	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AOC04_RS22345	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AOC04_RS22350	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOC04_RS22350	COG0302	gtp cyclohydrolase
AOC04_RS22355	COG0617	tRNA 3'-terminal CCA addition
AOC04_RS22360	COG2719	SpoVR family
AOC04_RS22365	COG2718	Belongs to the UPF0229 family
AOC04_RS22370	COG2766	serine protein kinase
AOC04_RS22375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOC04_RS22380	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOC04_RS22385	COG2967	ApaG domain
AOC04_RS22390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOC04_RS22395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOC04_RS22400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOC04_RS22405	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AOC04_RS22410	COG3178	'Phosphotransferase
AOC04_RS22415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOC04_RS22430	COG4585	Histidine kinase
AOC04_RS22435	COG2197	response regulator
AOC04_RS22440	COG3842	ATPase activity
AOC04_RS22450	COG1176	ABC-type spermidine putrescine transport system, permease component I
AOC04_RS22465	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOC04_RS22470	COG0546	phosphoglycolate phosphatase activity
AOC04_RS22480	COG0512	Glutamine amidotransferase of anthranilate synthase
AOC04_RS22485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOC04_RS22490	COG0134	indole-3-glycerol-phosphate synthase activity
AOC04_RS22505	COG1765	OsmC-like protein
AOC04_RS22510	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AOC04_RS22515	COG0537	adenosine 5'-monophosphoramidase activity
AOC04_RS22520	COG4221	oxidoreductase activity
AOC04_RS22535	COG1981	membrane
AOC04_RS22540	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AOC04_RS22545	COG0316	Belongs to the HesB IscA family
AOC04_RS22550	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOC04_RS22555	COG0739	heme binding
AOC04_RS22560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOC04_RS22580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AOC04_RS22580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AOC04_RS22585	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AOC04_RS22625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOC04_RS22630	COG0081	regulation of translation
AOC04_RS22635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOC04_RS22640	COG0222	ribosome binding
AOC04_RS22645	COG0085	RNA polymerase activity
AOC04_RS22650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOC04_RS22655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOC04_RS22660	COG0049	tRNA binding
AOC04_RS22665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOC04_RS22670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOC04_RS22675	COG0051	transcription antitermination factor activity, RNA binding
AOC04_RS22680	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOC04_RS22685	COG0088	Forms part of the polypeptide exit tunnel
AOC04_RS22690	COG0089	rRNA binding
AOC04_RS22695	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOC04_RS22700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOC04_RS22705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOC04_RS22710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOC04_RS22715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOC04_RS22720	COG0255	Belongs to the universal ribosomal protein uL29 family
AOC04_RS22725	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOC04_RS22730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOC04_RS22735	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOC04_RS22740	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOC04_RS22745	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOC04_RS22750	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOC04_RS22755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOC04_RS22760	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOC04_RS22765	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOC04_RS22770	COG1841	ribosomal large subunit assembly
AOC04_RS22775	COG0200	Binds to the 23S rRNA
AOC04_RS22785	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOC04_RS22790	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOC04_RS22795	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOC04_RS22800	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOC04_RS22805	COG0202	RNA polymerase activity
AOC04_RS22810	COG0203	ribosomal protein L17
AOC04_RS22820	COG2193	ferroxidase activity
AOC04_RS22825	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOC04_RS22830	COG2814	Major facilitator Superfamily
AOC04_RS22835	COG0629	single-stranded DNA binding
AOC04_RS22840	COG0668	transmembrane transport
AOC04_RS22850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOC04_RS22855	COG3047	cAMP biosynthetic process
AOC04_RS22885	COG3118	belongs to the thioredoxin family
AOC04_RS22890	COG2264	protein methyltransferase activity
AOC04_RS22900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOC04_RS22905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOC04_RS22905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOC04_RS22920	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AOC04_RS22925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOC04_RS22935	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AOC04_RS22945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AOC04_RS22950	COG4206	TonB-dependent receptor
AOC04_RS22955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOC04_RS22960	COG0142	geranyltranstransferase activity
AOC04_RS22965	COG1722	exodeoxyribonuclease VII activity
AOC04_RS22975	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AOC04_RS22980	COG0022	dehydrogenase e1 component
AOC04_RS22985	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOC04_RS22990	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOC04_RS23005	COG0583	DNA-binding transcription factor activity
AOC04_RS23015	COG0789	Transcriptional regulator
AOC04_RS23040	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AOC04_RS23050	COG0586	Pfam SNARE associated Golgi protein
AOC04_RS23055	COG4302	ethanolamine ammonia-lyase activity
AOC04_RS23060	COG4303	Ethanolamine ammonia lyase large subunit
AOC04_RS23065	COG0531	amino acid
AOC04_RS23075	COG3284	Transcriptional regulator
AOC04_RS23080	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOC04_RS23095	COG0702	epimerase
AOC04_RS23110	COG1346	cytolysis
AOC04_RS23120	COG0586	Pfam SNARE associated Golgi protein
AOC04_RS23125	COG2094	Belongs to the DNA glycosylase MPG family
AOC04_RS23130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AOC04_RS23135	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOC04_RS23145	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOC04_RS23150	COG0768	penicillin binding
AOC04_RS23155	COG0772	Belongs to the SEDS family
AOC04_RS23160	COG2951	lytic endotransglycosylase activity
AOC04_RS23170	COG1686	Belongs to the peptidase S11 family
AOC04_RS23175	COG2921	Belongs to the UPF0250 family
AOC04_RS23180	COG0321	lipoyl(octanoyl) transferase activity
AOC04_RS23185	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOC04_RS23190	COG1619	proteins homologs of microcin C7 resistance protein MccF
AOC04_RS23195	COG2951	lytic endotransglycosylase activity