locus-tag	class	description
HMPREF9154_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HMPREF9154_RS00010	COG0592	DNA-directed DNA polymerase activity
HMPREF9154_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HMPREF9154_RS00055	COG0187	DNA topoisomerase II activity
HMPREF9154_RS00060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9154_RS00070	COG2814	Major facilitator Superfamily
HMPREF9154_RS00075	COG0640	Transcriptional regulator
HMPREF9154_RS00090	COG0747	negative chemotaxis
HMPREF9154_RS00095	COG0601	transmembrane transport
HMPREF9154_RS00100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_RS00105	COG0444	Belongs to the ABC transporter superfamily
HMPREF9154_RS00110	COG4608	Belongs to the ABC transporter superfamily
HMPREF9154_RS00115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_RS00120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_RS00125	COG1121	(ABC) transporter
HMPREF9154_RS00130	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9154_RS00200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HMPREF9154_RS00205	COG0205	6-phosphofructokinase activity
HMPREF9154_RS00230	COG1131	(ABC) transporter
HMPREF9154_RS00255	COG1131	(ABC) transporter
HMPREF9154_RS00260	COG1309	transcriptional regulator
HMPREF9154_RS00295	COG0316	Belongs to the HesB IscA family
HMPREF9154_RS00295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HMPREF9154_RS00315	COG0561	phosphatase activity
HMPREF9154_RS00345	COG2814	Major facilitator Superfamily
HMPREF9154_RS00350	COG0640	Transcriptional regulator
HMPREF9154_RS00370	COG3739	integral membrane protein
HMPREF9154_RS00375	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HMPREF9154_RS00385	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HMPREF9154_RS00500	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HMPREF9154_RS00530	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF9154_RS00535	COG1116	anion transmembrane transporter activity
HMPREF9154_RS00560	COG1120	ATPase activity
HMPREF9154_RS00565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS00570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_RS00600	COG1309	transcriptional regulator
HMPREF9154_RS00610	COG0667	Aldo Keto reductase
HMPREF9154_RS00630	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS00635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HMPREF9154_RS00640	COG2197	response regulator
HMPREF9154_RS00705	COG3718	enzyme involved in inositol metabolism
HMPREF9154_RS00710	COG3962	Belongs to the TPP enzyme family
HMPREF9154_RS00750	COG1175	transmembrane transport
HMPREF9154_RS00755	COG0395	ABC-type sugar transport system, permease component
HMPREF9154_RS00780	COG0456	acetyltransferase
HMPREF9154_RS00795	COG1902	pentaerythritol trinitrate reductase activity
HMPREF9154_RS00815	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_RS00825	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS00840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_RS00845	COG1879	ABC-type sugar transport system periplasmic component
HMPREF9154_RS00850	COG1609	Transcriptional regulator
HMPREF9154_RS00905	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_RS00925	COG3022	response to hydroperoxide
HMPREF9154_RS00940	COG0438	transferase activity, transferring glycosyl groups
HMPREF9154_RS00945	COG1132	(ABC) transporter
HMPREF9154_RS00960	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMPREF9154_RS00970	COG5002	protein histidine kinase activity
HMPREF9154_RS00975	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS01005	COG1404	Belongs to the peptidase S8 family
HMPREF9154_RS01010	COG3266	domain, Protein
HMPREF9154_RS01040	COG1674	ftsk spoiiie
HMPREF9154_RS01090	COG1136	(ABC) transporter
HMPREF9154_RS01095	COG1131	(ABC) transporter
HMPREF9154_RS01110	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS01120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HMPREF9154_RS01190	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS01210	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF9154_RS01225	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9154_RS01235	COG1309	transcriptional regulator
HMPREF9154_RS01245	COG1132	(ABC) transporter
HMPREF9154_RS01245	COG2375	cellular response to nickel ion
HMPREF9154_RS01250	COG1122	ATPase activity
HMPREF9154_RS01260	COG1129	ABC transporter
HMPREF9154_RS01270	COG0305	Participates in initiation and elongation during chromosome replication
HMPREF9154_RS01275	COG1937	Protein conserved in bacteria
HMPREF9154_RS01290	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF9154_RS01295	COG0477	Major facilitator Superfamily
HMPREF9154_RS01315	COG2197	response regulator
HMPREF9154_RS01320	COG4585	Histidine kinase
HMPREF9154_RS01325	COG1131	(ABC) transporter
HMPREF9154_RS01335	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HMPREF9154_RS01340	COG4988	ABC transporter
HMPREF9154_RS01365	COG1294	oxidase, subunit
HMPREF9154_RS01370	COG1271	oxidase subunit
HMPREF9154_RS01425	COG0300	oxidoreductase activity
HMPREF9154_RS01455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HMPREF9154_RS01465	COG1027	Aspartate ammonia-lyase
HMPREF9154_RS01470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HMPREF9154_RS01475	COG1940	carbohydrate kinase activity
HMPREF9154_RS01485	COG1175	transmembrane transport
HMPREF9154_RS01490	COG0395	ABC-type sugar transport system, permease component
HMPREF9154_RS01495	COG1940	carbohydrate kinase activity
HMPREF9154_RS01525	COG0366	Alpha amylase catalytic
HMPREF9154_RS01555	COG2205	protein histidine kinase activity
HMPREF9154_RS01585	COG0022	dehydrogenase e1 component
HMPREF9154_RS01590	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_RS01600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9154_RS01610	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HMPREF9154_RS01635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HMPREF9154_RS01640	COG0561	phosphatase activity
HMPREF9154_RS01700	COG0494	nUDIX hydrolase
HMPREF9154_RS01740	COG2197	response regulator
HMPREF9154_RS01745	COG1136	(ABC) transporter
HMPREF9154_RS01745	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS01750	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS01750	COG1136	(ABC) transporter
HMPREF9154_RS01810	COG2226	methyltransferase
HMPREF9154_RS01845	COG2197	response regulator
HMPREF9154_RS01865	COG1205	dead DEAH box helicase
HMPREF9154_RS01865	COG1111	helicase
HMPREF9154_RS01885	COG1648	precorrin-2 dehydrogenase activity
HMPREF9154_RS01885	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF9154_RS01940	COG1132	(ABC) transporter
HMPREF9154_RS01975	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_RS01985	COG1595	DNA-templated transcription, initiation
HMPREF9154_RS01990	COG1252	NADH dehydrogenase
HMPREF9154_RS02000	COG0302	gtp cyclohydrolase
HMPREF9154_RS02005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HMPREF9154_RS02010	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HMPREF9154_RS02040	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HMPREF9154_RS02055	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_RS02060	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HMPREF9154_RS02070	COG1082	Xylose isomerase domain protein TIM barrel
HMPREF9154_RS02095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HMPREF9154_RS02105	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS02130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HMPREF9154_RS02145	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HMPREF9154_RS02160	COG1401	restriction endodeoxyribonuclease activity
HMPREF9154_RS02175	COG0494	nUDIX hydrolase
HMPREF9154_RS02175	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_RS02180	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HMPREF9154_RS02185	COG0456	acetyltransferase
HMPREF9154_RS02190	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS02210	COG1490	D-aminoacyl-tRNA deacylase activity
HMPREF9154_RS02215	COG3485	protocatechuate 3,4-dioxygenase
HMPREF9154_RS02220	COG0354	folic acid binding
HMPREF9154_RS02240	COG2326	polyphosphate kinase activity
HMPREF9154_RS02255	COG0583	DNA-binding transcription factor activity
HMPREF9154_RS02285	COG1217	gtp-binding protein TYPA
HMPREF9154_RS02305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_RS02310	COG1461	Dihydroxyacetone kinase
HMPREF9154_RS02315	COG2376	Dihydroxyacetone kinase
HMPREF9154_RS02320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HMPREF9154_RS02335	COG3189	MarR family transcriptional regulator
HMPREF9154_RS02365	COG0151	Belongs to the GarS family
HMPREF9154_RS02370	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HMPREF9154_RS02390	COG1668	transmembrane transport
HMPREF9154_RS02395	COG4152	abc transporter atp-binding protein
HMPREF9154_RS02400	COG2197	response regulator
HMPREF9154_RS02405	COG4585	Histidine kinase
HMPREF9154_RS02410	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS02410	COG1136	(ABC) transporter
HMPREF9154_RS02420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HMPREF9154_RS02435	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9154_RS02440	COG0047	phosphoribosylformylglycinamidine synthase activity
HMPREF9154_RS02460	COG0427	acetyl-CoA hydrolase
HMPREF9154_RS02470	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF9154_RS02475	COG4115	mRNA cleavage
HMPREF9154_RS02480	COG2161	toxin-antitoxin pair type II binding
HMPREF9154_RS02495	COG4585	Histidine kinase
HMPREF9154_RS02505	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HMPREF9154_RS02520	COG1331	Highly conserved protein containing a thioredoxin domain
HMPREF9154_RS02530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_RS02535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HMPREF9154_RS02570	COG2814	Major facilitator Superfamily
HMPREF9154_RS02575	COG1309	transcriptional regulator
HMPREF9154_RS02595	COG0785	Cytochrome C biogenesis protein
HMPREF9154_RS02595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF9154_RS02605	COG5002	protein histidine kinase activity
HMPREF9154_RS02615	COG0133	tryptophan synthase activity
HMPREF9154_RS02620	COG2233	PERMEase
HMPREF9154_RS02645	COG0084	hydrolase, TatD family'
HMPREF9154_RS02650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HMPREF9154_RS02655	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HMPREF9154_RS02670	COG1136	(ABC) transporter
HMPREF9154_RS02670	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS02685	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_RS02700	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HMPREF9154_RS02705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF9154_RS02720	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS02720	COG1136	(ABC) transporter
HMPREF9154_RS02725	COG1136	(ABC) transporter
HMPREF9154_RS02725	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS02735	COG1131	(ABC) transporter
HMPREF9154_RS02750	COG2094	Belongs to the DNA glycosylase MPG family
HMPREF9154_RS02760	COG0583	DNA-binding transcription factor activity
HMPREF9154_RS02780	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HMPREF9154_RS02785	COG0193	aminoacyl-tRNA hydrolase activity
HMPREF9154_RS02810	COG2304	oxidoreductase activity
HMPREF9154_RS02820	COG0148	phosphopyruvate hydratase activity
HMPREF9154_RS02845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HMPREF9154_RS02845	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HMPREF9154_RS02850	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HMPREF9154_RS02855	COG3831	ATPase activity
HMPREF9154_RS02880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9154_RS02890	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9154_RS02895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF9154_RS02900	COG2188	Transcriptional regulator
HMPREF9154_RS02910	COG0095	Lipoate-protein ligase
HMPREF9154_RS02925	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS02930	COG4191	Histidine kinase
HMPREF9154_RS02950	COG0765	amino acid transport
HMPREF9154_RS02970	COG1518	maintenance of DNA repeat elements
HMPREF9154_RS02970	COG1468	defense response to virus
HMPREF9154_RS02975	COG1203	CRISPR-associated helicase, Cas3
HMPREF9154_RS02995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HMPREF9154_RS03000	COG3591	Belongs to the peptidase S1B family
HMPREF9154_RS03050	COG1349	DNA-binding transcription factor activity
HMPREF9154_RS03055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_RS03060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_RS03065	COG0022	dehydrogenase e1 component
HMPREF9154_RS03080	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS03105	COG2376	Dihydroxyacetone kinase
HMPREF9154_RS03110	COG1063	alcohol dehydrogenase
HMPREF9154_RS03125	COG1113	amino acid transport
HMPREF9154_RS03130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HMPREF9154_RS03140	COG1472	Belongs to the glycosyl hydrolase 3 family
HMPREF9154_RS03155	COG0657	acetylesterase activity
HMPREF9154_RS03155	COG2755	lipolytic protein G-D-S-L family
HMPREF9154_RS03160	COG0823	Involved in the tonB-independent uptake of proteins
HMPREF9154_RS03160	COG1506	peptidase
HMPREF9154_RS03160	COG4946	Tricorn protease homolog
HMPREF9154_RS03215	COG0038	chloride channel
HMPREF9154_RS03220	COG0588	phosphoglycerate mutase activity
HMPREF9154_RS03225	COG0726	polysaccharide deacetylase
HMPREF9154_RS03235	COG0704	Plays a role in the regulation of phosphate uptake
HMPREF9154_RS03240	COG5002	protein histidine kinase activity
HMPREF9154_RS03245	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS03250	COG1329	Transcriptional regulator
HMPREF9154_RS03255	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HMPREF9154_RS03260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HMPREF9154_RS03285	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_RS03310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HMPREF9154_RS03320	COG1132	(ABC) transporter
HMPREF9154_RS03320	COG2375	cellular response to nickel ion
HMPREF9154_RS03330	COG0789	Transcriptional regulator
HMPREF9154_RS03335	COG0698	ribose 5-phosphate isomerase
HMPREF9154_RS03345	COG0215	cysteine-tRNA ligase activity
HMPREF9154_RS03360	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS03365	COG2205	protein histidine kinase activity
HMPREF9154_RS03370	COG2132	Multicopper oxidase
HMPREF9154_RS03395	COG2226	methyltransferase
HMPREF9154_RS03405	COG3541	Predicted nucleotidyltransferase
HMPREF9154_RS03420	COG1882	Formate acetyltransferase
HMPREF9154_RS03425	COG0626	cystathionine gamma-synthase activity
HMPREF9154_RS03430	COG3842	ATPase activity
HMPREF9154_RS03445	COG0275	rRNA processing
HMPREF9154_RS03470	COG0454	-acetyltransferase
HMPREF9154_RS03485	COG3142	Participates in the control of copper homeostasis
HMPREF9154_RS03490	COG0494	nUDIX hydrolase
HMPREF9154_RS03500	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9154_RS03505	COG1278	Cold shock
HMPREF9154_RS03515	COG2252	PERMEase
HMPREF9154_RS03535	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HMPREF9154_RS03550	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HMPREF9154_RS03565	COG1321	iron dependent repressor
HMPREF9154_RS03570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HMPREF9154_RS03580	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_RS03580	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_RS03580	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HMPREF9154_RS03580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF9154_RS03600	COG1125	glycine betaine transport
HMPREF9154_RS03600	COG0517	IMP dehydrogenase activity
HMPREF9154_RS03610	COG1174	glycine betaine transport
HMPREF9154_RS03620	COG0477	Major facilitator Superfamily
HMPREF9154_RS03640	COG0604	alcohol dehydrogenase
HMPREF9154_RS03665	COG3048	D-serine ammonia-lyase activity
HMPREF9154_RS03690	COG1304	FMN binding
HMPREF9154_RS03710	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS03715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS03720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF9154_RS03725	COG1120	ATPase activity
HMPREF9154_RS03760	COG1140	nitrate reductase beta subunit
HMPREF9154_RS03790	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF9154_RS03805	COG1609	Transcriptional regulator
HMPREF9154_RS03825	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_RS03865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS03870	COG1120	ATPase activity
HMPREF9154_RS03910	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HMPREF9154_RS03915	COG0314	molybdopterin synthase activity
HMPREF9154_RS03990	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HMPREF9154_RS04000	COG2986	histidine ammonia-lyase
HMPREF9154_RS04010	COG0366	Alpha amylase catalytic
HMPREF9154_RS04040	COG1131	(ABC) transporter
HMPREF9154_RS04070	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HMPREF9154_RS04075	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HMPREF9154_RS04090	COG4721	ABC-type cobalt transport system, permease component
HMPREF9154_RS04095	COG3845	ABC transporter
HMPREF9154_RS04140	COG1263	PTS System
HMPREF9154_RS04140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HMPREF9154_RS04140	COG2190	(PTS) system
HMPREF9154_RS04145	COG1404	Belongs to the peptidase S8 family
HMPREF9154_RS04155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_RS04155	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF9154_RS04160	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF9154_RS04160	COG0351	phosphomethylpyrimidine kinase
HMPREF9154_RS04160	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9154_RS04165	COG0351	phosphomethylpyrimidine kinase
HMPREF9154_RS04170	COG0351	phosphomethylpyrimidine kinase
HMPREF9154_RS04170	COG0352	thiamine-phosphate diphosphorylase activity
HMPREF9154_RS04170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HMPREF9154_RS04180	COG1404	Belongs to the peptidase S8 family
HMPREF9154_RS04230	COG0514	ATP-dependent DNA helicase (RecQ)
HMPREF9154_RS04235	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HMPREF9154_RS04240	COG0542	response to heat
HMPREF9154_RS04270	COG5012	cobalamin binding
HMPREF9154_RS04285	COG1113	amino acid transport
HMPREF9154_RS04290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_RS04295	COG0534	Mate efflux family protein
HMPREF9154_RS04320	COG0714	Associated with various cellular activities
HMPREF9154_RS04345	COG2815	serine threonine protein kinase
HMPREF9154_RS04345	COG0515	serine threonine protein kinase
HMPREF9154_RS04360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HMPREF9154_RS04365	COG1704	LemA family
HMPREF9154_RS04385	COG0191	fructose-bisphosphate aldolase activity
HMPREF9154_RS04395	COG1172	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_RS04410	COG1070	Carbohydrate kinase
HMPREF9154_RS04435	COG1045	serine acetyltransferase
HMPREF9154_RS04440	COG4770	biotin carboxylase activity
HMPREF9154_RS04485	COG0424	maF-like protein
HMPREF9154_RS04495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HMPREF9154_RS04530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HMPREF9154_RS04540	COG1316	TRANSCRIPTIONal
HMPREF9154_RS04600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_RS04605	COG2835	tetraacyldisaccharide 4'-kinase activity
HMPREF9154_RS04615	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HMPREF9154_RS04655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HMPREF9154_RS04660	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HMPREF9154_RS04665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HMPREF9154_RS04670	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HMPREF9154_RS04675	COG0714	Associated with various cellular activities
HMPREF9154_RS04690	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_RS04695	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HMPREF9154_RS04710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HMPREF9154_RS04725	COG0156	8-amino-7-oxononanoate synthase activity
HMPREF9154_RS04730	COG1063	alcohol dehydrogenase
HMPREF9154_RS04740	COG0259	pyridoxamine-phosphate oxidase activity
HMPREF9154_RS04760	COG1739	Uncharacterized protein family UPF0029
HMPREF9154_RS04790	COG1053	succinate dehydrogenase
HMPREF9154_RS04800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HMPREF9154_RS04820	COG0431	NADPH-dependent FMN reductase
HMPREF9154_RS04850	COG0189	ligase activity
HMPREF9154_RS04860	COG1073	alpha beta
HMPREF9154_RS04875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS04880	COG3321	synthase
HMPREF9154_RS04900	COG2070	2-Nitropropane dioxygenase
HMPREF9154_RS04900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF9154_RS04905	COG1024	Enoyl-CoA hydratase
HMPREF9154_RS04910	COG3321	synthase
HMPREF9154_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS04910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_RS04910	COG4221	oxidoreductase activity
HMPREF9154_RS04915	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS04915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_RS04915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HMPREF9154_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS04915	COG3321	synthase
HMPREF9154_RS04920	COG0300	oxidoreductase activity
HMPREF9154_RS04920	COG3321	synthase
HMPREF9154_RS04920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS04920	COG4221	oxidoreductase activity
HMPREF9154_RS04945	COG3425	synthase
HMPREF9154_RS04950	COG1024	Enoyl-CoA hydratase
HMPREF9154_RS04965	COG1131	(ABC) transporter
HMPREF9154_RS05000	COG0252	asparaginase activity
HMPREF9154_RS05030	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HMPREF9154_RS05050	COG1160	GTP binding
HMPREF9154_RS05060	COG0322	excinuclease ABC activity
HMPREF9154_RS05075	COG1268	BioY protein
HMPREF9154_RS05080	COG1122	ATPase activity
HMPREF9154_RS05090	COG1660	Displays ATPase and GTPase activities
HMPREF9154_RS05095	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HMPREF9154_RS05105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HMPREF9154_RS05110	COG0126	phosphoglycerate kinase activity
HMPREF9154_RS05115	COG0149	triose-phosphate isomerase activity
HMPREF9154_RS05120	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HMPREF9154_RS05145	COG0363	glucosamine-6-phosphate deaminase activity
HMPREF9154_RS05185	COG0396	ATPase activity
HMPREF9154_RS05190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HMPREF9154_RS05195	COG0822	iron-sulfur transferase activity
HMPREF9154_RS05205	COG2267	carboxylic ester hydrolase activity
HMPREF9154_RS05225	COG0488	(ABC) transporter
HMPREF9154_RS05230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_RS05250	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS05260	COG1119	ATPase activity
HMPREF9154_RS05265	COG0114	fumarate hydratase activity
HMPREF9154_RS05295	COG0242	peptide deformylase activity
HMPREF9154_RS05300	COG4974	Belongs to the 'phage' integrase family
HMPREF9154_RS05315	COG0052	Belongs to the universal ribosomal protein uS2 family
HMPREF9154_RS05320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HMPREF9154_RS05325	COG0528	UMP kinase activity
HMPREF9154_RS05330	COG0233	cytoplasmic translational termination
HMPREF9154_RS05335	COG0575	Belongs to the CDS family
HMPREF9154_RS05340	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HMPREF9154_RS05345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HMPREF9154_RS05350	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HMPREF9154_RS05355	COG0750	zinc metalloprotease
HMPREF9154_RS05360	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HMPREF9154_RS05370	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HMPREF9154_RS05375	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HMPREF9154_RS05380	COG1492	cobalamin metabolic process
HMPREF9154_RS05395	COG1253	flavin adenine dinucleotide binding
HMPREF9154_RS05405	COG1744	ABC transporter substrate-binding protein PnrA-like
HMPREF9154_RS05410	COG3845	ABC transporter
HMPREF9154_RS05420	COG1079	Belongs to the binding-protein-dependent transport system permease family
HMPREF9154_RS05430	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HMPREF9154_RS05435	COG0328	RNA-DNA hybrid ribonuclease activity
HMPREF9154_RS05445	COG0823	Involved in the tonB-independent uptake of proteins
HMPREF9154_RS05445	COG1506	peptidase
HMPREF9154_RS05445	COG4946	Tricorn protease homolog
HMPREF9154_RS05450	COG1131	(ABC) transporter
HMPREF9154_RS05460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9154_RS05475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_RS05490	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9154_RS05505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HMPREF9154_RS05530	COG0714	Associated with various cellular activities
HMPREF9154_RS05540	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_RS05575	COG1342	Belongs to the UPF0251 family
HMPREF9154_RS05585	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HMPREF9154_RS05600	COG0616	signal peptide processing
HMPREF9154_RS05640	COG2171	N-acyltransferase activity
HMPREF9154_RS05645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9154_RS05660	COG0297	glycogen (starch) synthase activity
HMPREF9154_RS05665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HMPREF9154_RS05675	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HMPREF9154_RS05680	COG1595	DNA-templated transcription, initiation
HMPREF9154_RS05690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF9154_RS05720	COG0006	proline dipeptidase activity
HMPREF9154_RS05730	COG0557	exoribonuclease II activity
HMPREF9154_RS05800	COG0174	glutamine synthetase
HMPREF9154_RS05810	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HMPREF9154_RS05815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HMPREF9154_RS05820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HMPREF9154_RS05825	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HMPREF9154_RS05830	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_RS05840	COG1349	DNA-binding transcription factor activity
HMPREF9154_RS05845	COG1063	alcohol dehydrogenase
HMPREF9154_RS05850	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_RS05850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_RS05860	COG2409	Drug exporters of the RND superfamily
HMPREF9154_RS05865	COG0174	glutamine synthetase
HMPREF9154_RS05870	COG1131	(ABC) transporter
HMPREF9154_RS05885	COG1309	transcriptional regulator
HMPREF9154_RS05930	COG2188	Transcriptional regulator
HMPREF9154_RS05935	COG0488	(ABC) transporter
HMPREF9154_RS05945	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HMPREF9154_RS05950	COG0321	lipoyl(octanoyl) transferase activity
HMPREF9154_RS05960	COG0310	cobalt ion transport
HMPREF9154_RS06015	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HMPREF9154_RS06020	COG1797	cobyrinic acid a,c-diamide synthase activity
HMPREF9154_RS06025	COG1648	precorrin-2 dehydrogenase activity
HMPREF9154_RS06025	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HMPREF9154_RS06040	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HMPREF9154_RS06045	COG0456	acetyltransferase
HMPREF9154_RS06050	COG0442	prolyl-tRNA aminoacylation
HMPREF9154_RS06060	COG0779	Required for maturation of 30S ribosomal subunits
HMPREF9154_RS06065	COG0195	Participates in both transcription termination and antitermination
HMPREF9154_RS06080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HMPREF9154_RS06085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HMPREF9154_RS06090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HMPREF9154_RS06095	COG2186	Transcriptional regulator
HMPREF9154_RS06100	COG4139	cobalamin transport
HMPREF9154_RS06115	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HMPREF9154_RS06120	COG4106	trans-aconitate 2-methyltransferase activity
HMPREF9154_RS06125	COG1620	l-lactate permease
HMPREF9154_RS06130	COG0247	lactate metabolic process
HMPREF9154_RS06135	COG1139	Iron-sulfur cluster binding protein
HMPREF9154_RS06140	COG1556	Lactate utilization protein
HMPREF9154_RS06150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HMPREF9154_RS06155	COG1185	polyribonucleotide nucleotidyltransferase activity
HMPREF9154_RS06160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HMPREF9154_RS06170	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HMPREF9154_RS06175	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF9154_RS06190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HMPREF9154_RS06195	COG1124	(ABC) transporter
HMPREF9154_RS06200	COG4172	Belongs to the ABC transporter superfamily
HMPREF9154_RS06205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_RS06210	COG0601	transmembrane transport
HMPREF9154_RS06220	COG0003	Pfam Anion-transporting ATPase
HMPREF9154_RS06230	COG0003	Pfam Anion-transporting ATPase
HMPREF9154_RS06235	COG1846	Transcriptional regulator
HMPREF9154_RS06245	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HMPREF9154_RS06250	COG0571	ribonuclease III activity
HMPREF9154_RS06255	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HMPREF9154_RS06265	COG1196	nuclear chromosome segregation
HMPREF9154_RS06275	COG0640	Transcriptional regulator
HMPREF9154_RS06285	COG2197	response regulator
HMPREF9154_RS06295	COG4585	Histidine kinase
HMPREF9154_RS06310	COG0616	signal peptide processing
HMPREF9154_RS06320	COG0228	four-way junction DNA binding
HMPREF9154_RS06325	COG1837	Belongs to the UPF0109 family
HMPREF9154_RS06330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HMPREF9154_RS06335	COG0336	Belongs to the RNA methyltransferase TrmD family
HMPREF9154_RS06345	COG1053	succinate dehydrogenase
HMPREF9154_RS06350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HMPREF9154_RS06355	COG0335	large ribosomal subunit rRNA binding
HMPREF9154_RS06365	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HMPREF9154_RS06375	COG0792	nuclease activity
HMPREF9154_RS06415	COG0440	acetolactate synthase activity
HMPREF9154_RS06420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HMPREF9154_RS06425	COG0477	Major facilitator Superfamily
HMPREF9154_RS06430	COG1061	Type III restriction enzyme res subunit
HMPREF9154_RS06445	COG0473	3-isopropylmalate dehydrogenase activity
HMPREF9154_RS06450	COG0179	Fumarylacetoacetate (FAA) hydrolase
HMPREF9154_RS06475	COG2197	response regulator
HMPREF9154_RS06485	COG1131	(ABC) transporter
HMPREF9154_RS06500	COG1414	Transcriptional regulator
HMPREF9154_RS06505	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HMPREF9154_RS06510	COG0066	3-isopropylmalate dehydratase activity
HMPREF9154_RS06525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS06530	COG1120	ATPase activity
HMPREF9154_RS06545	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9154_RS06555	COG3585	molybdate ion transport
HMPREF9154_RS06560	COG1674	ftsk spoiiie
HMPREF9154_RS06565	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF9154_RS06590	COG2137	regulation of response to DNA damage stimulus
HMPREF9154_RS06595	COG1418	mRNA catabolic process
HMPREF9154_RS06600	COG2017	converts alpha-aldose to the beta-anomer
HMPREF9154_RS06605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HMPREF9154_RS06615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HMPREF9154_RS06620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HMPREF9154_RS06625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HMPREF9154_RS06635	COG4942	peptidase
HMPREF9154_RS06645	COG0747	negative chemotaxis
HMPREF9154_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_RS06670	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HMPREF9154_RS06675	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9154_RS06680	COG1162	GTPase activity
HMPREF9154_RS06685	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HMPREF9154_RS06695	COG1595	DNA-templated transcription, initiation
HMPREF9154_RS06715	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9154_RS06720	COG0567	Dehydrogenase, E1 component
HMPREF9154_RS06720	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_RS06750	COG0460	homoserine dehydrogenase
HMPREF9154_RS06755	COG0083	homoserine kinase activity
HMPREF9154_RS06765	COG0254	rRNA binding
HMPREF9154_RS06770	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HMPREF9154_RS06775	COG2890	protein-(glutamine-N5) methyltransferase activity
HMPREF9154_RS06785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9154_RS06795	COG0356	it plays a direct role in the translocation of protons across the membrane
HMPREF9154_RS06800	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF9154_RS06805	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HMPREF9154_RS06810	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HMPREF9154_RS06815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HMPREF9154_RS06820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HMPREF9154_RS06825	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HMPREF9154_RS06830	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HMPREF9154_RS06845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF9154_RS06850	COG0596	Alpha beta hydrolase
HMPREF9154_RS06895	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF9154_RS06900	COG1381	Involved in DNA repair and RecF pathway recombination
HMPREF9154_RS06910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HMPREF9154_RS06915	COG1120	ATPase activity
HMPREF9154_RS06920	COG0803	Belongs to the bacterial solute-binding protein 9 family
HMPREF9154_RS06935	COG1175	transmembrane transport
HMPREF9154_RS06950	COG1940	carbohydrate kinase activity
HMPREF9154_RS06955	COG0339	signal peptide processing
HMPREF9154_RS06975	COG1136	(ABC) transporter
HMPREF9154_RS06980	COG3851	Histidine kinase
HMPREF9154_RS06985	COG2197	response regulator
HMPREF9154_RS06990	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HMPREF9154_RS06995	COG1131	(ABC) transporter
HMPREF9154_RS07010	COG2197	response regulator
HMPREF9154_RS07030	COG0406	alpha-ribazole phosphatase activity
HMPREF9154_RS07115	COG0714	Associated with various cellular activities
HMPREF9154_RS07125	COG2304	oxidoreductase activity
HMPREF9154_RS07130	COG2304	oxidoreductase activity
HMPREF9154_RS07150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS07155	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HMPREF9154_RS07160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HMPREF9154_RS07170	COG1653	transport
HMPREF9154_RS07175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HMPREF9154_RS07185	COG0205	6-phosphofructokinase activity
HMPREF9154_RS07205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HMPREF9154_RS07210	COG2884	Cell division ATP-binding protein ftsE
HMPREF9154_RS07225	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HMPREF9154_RS07235	COG0366	Alpha amylase catalytic
HMPREF9154_RS07240	COG1678	Uncharacterized ACR, COG1678
HMPREF9154_RS07245	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS07255	COG5401	PFAM Sporulation and spore germination
HMPREF9154_RS07265	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HMPREF9154_RS07270	COG0653	protein targeting
HMPREF9154_RS07290	COG0613	PHP domain protein
HMPREF9154_RS07295	COG0180	Tryptophanyl-tRNA synthetase
HMPREF9154_RS07300	COG0513	Belongs to the DEAD box helicase family
HMPREF9154_RS07315	COG1278	Cold shock
HMPREF9154_RS07335	COG0187	DNA topoisomerase II activity
HMPREF9154_RS07350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HMPREF9154_RS07375	COG1435	thymidine kinase activity
HMPREF9154_RS07395	COG0756	dUTP diphosphatase activity
HMPREF9154_RS07415	COG0569	domain protein
HMPREF9154_RS07420	COG0531	amino acid
HMPREF9154_RS07425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HMPREF9154_RS07430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HMPREF9154_RS07435	COG0686	Belongs to the AlaDH PNT family
HMPREF9154_RS07440	COG1113	amino acid transport
HMPREF9154_RS07445	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HMPREF9154_RS07460	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HMPREF9154_RS07500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HMPREF9154_RS07530	COG1716	ATPase activity
HMPREF9154_RS07550	COG1295	ribonuclease BN
HMPREF9154_RS07570	COG0009	L-threonylcarbamoyladenylate synthase
HMPREF9154_RS07580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HMPREF9154_RS07590	COG4552	Acetyltransferase involved in intracellular survival and related
HMPREF9154_RS07595	COG1937	Protein conserved in bacteria
HMPREF9154_RS07605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HMPREF9154_RS07610	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HMPREF9154_RS07625	COG3030	protein affecting phage T7 exclusion by the F plasmid
HMPREF9154_RS07630	COG1216	Glycosyl transferase, family 2
HMPREF9154_RS07635	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HMPREF9154_RS07640	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMPREF9154_RS07640	COG2813	Specifically methylates the guanine in position
HMPREF9154_RS07645	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HMPREF9154_RS07655	COG2212	antiporter activity
HMPREF9154_RS07660	COG1863	multisubunit Na H antiporter MnhE subunit
HMPREF9154_RS07665	COG0651	ATP synthesis coupled electron transport
HMPREF9154_RS07670	COG1006	Multisubunit Na H antiporter MnhC subunit
HMPREF9154_RS07675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HMPREF9154_RS07675	COG2111	Na H antiporter
HMPREF9154_RS07680	COG1376	ErfK ybiS ycfS ynhG family protein
HMPREF9154_RS07695	COG0702	epimerase
HMPREF9154_RS07705	COG1160	GTP binding
HMPREF9154_RS07710	COG0488	(ABC) transporter
HMPREF9154_RS07720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HMPREF9154_RS07735	COG1410	methionine synthase
HMPREF9154_RS07735	COG0646	methionine synthase
HMPREF9154_RS07765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HMPREF9154_RS07775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HMPREF9154_RS07785	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HMPREF9154_RS07790	COG1758	RNA polymerase activity
HMPREF9154_RS07795	COG0194	GDP metabolic process
HMPREF9154_RS07805	COG0284	orotidine-5'-phosphate decarboxylase activity
HMPREF9154_RS07810	COG0167	dihydroorotate dehydrogenase activity
HMPREF9154_RS07815	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HMPREF9154_RS07820	COG0505	Belongs to the CarA family
HMPREF9154_RS07825	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HMPREF9154_RS07830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HMPREF9154_RS07835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HMPREF9154_RS07840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HMPREF9154_RS07845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HMPREF9154_RS07850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9154_RS07855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HMPREF9154_RS07860	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HMPREF9154_RS07865	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HMPREF9154_RS07885	COG2814	Major facilitator Superfamily
HMPREF9154_RS07895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HMPREF9154_RS07900	COG0124	histidyl-tRNA synthetase
HMPREF9154_RS07910	COG1196	nuclear chromosome segregation
HMPREF9154_RS07915	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HMPREF9154_RS07925	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HMPREF9154_RS07930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF9154_RS07935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HMPREF9154_RS07940	COG1862	Preprotein translocase
HMPREF9154_RS07945	COG2255	four-way junction helicase activity
HMPREF9154_RS07950	COG0632	four-way junction helicase activity
HMPREF9154_RS07955	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HMPREF9154_RS07960	COG0217	transcriptional regulatory protein
HMPREF9154_RS07965	COG0456	acetyltransferase
HMPREF9154_RS07985	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HMPREF9154_RS07990	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HMPREF9154_RS07995	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HMPREF9154_RS08000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMPREF9154_RS08005	COG0131	Imidazoleglycerol-phosphate dehydratase
HMPREF9154_RS08010	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HMPREF9154_RS08015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HMPREF9154_RS08025	COG0587	DNA-directed DNA polymerase activity
HMPREF9154_RS08040	COG2197	response regulator
HMPREF9154_RS08045	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS08045	COG1136	(ABC) transporter
HMPREF9154_RS08060	COG3842	ATPase activity
HMPREF9154_RS08075	COG1653	transport
HMPREF9154_RS08080	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS08090	COG0159	tryptophan synthase activity
HMPREF9154_RS08095	COG0133	tryptophan synthase activity
HMPREF9154_RS08100	COG0134	indole-3-glycerol-phosphate synthase activity
HMPREF9154_RS08105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HMPREF9154_RS08110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HMPREF9154_RS08125	COG1690	Belongs to the RtcB family
HMPREF9154_RS08135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9154_RS08140	COG0154	amidase activity
HMPREF9154_RS08145	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HMPREF9154_RS08170	COG4585	Histidine kinase
HMPREF9154_RS08175	COG2197	response regulator
HMPREF9154_RS08200	COG0482	sulfurtransferase activity
HMPREF9154_RS08220	COG0366	Alpha amylase catalytic
HMPREF9154_RS08225	COG3281	Trehalose synthase
HMPREF9154_RS08230	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HMPREF9154_RS08265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HMPREF9154_RS08270	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HMPREF9154_RS08280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HMPREF9154_RS08295	COG1609	Transcriptional regulator
HMPREF9154_RS08315	COG0343	queuine tRNA-ribosyltransferase activity
HMPREF9154_RS08330	COG0484	heat shock protein binding
HMPREF9154_RS08335	COG1420	regulation of RNA biosynthetic process
HMPREF9154_RS08345	COG0483	inositol monophosphate 1-phosphatase activity
HMPREF9154_RS08360	COG1131	(ABC) transporter
HMPREF9154_RS08370	COG4221	oxidoreductase activity
HMPREF9154_RS08395	COG2318	DinB family
HMPREF9154_RS08410	COG1175	transmembrane transport
HMPREF9154_RS08425	COG0481	GTPase activity
HMPREF9154_RS08430	COG0268	Binds directly to 16S ribosomal RNA
HMPREF9154_RS08435	COG4868	Belongs to the UPF0371 family
HMPREF9154_RS08465	COG3851	Histidine kinase
HMPREF9154_RS08470	COG2197	response regulator
HMPREF9154_RS08475	COG0277	FAD linked oxidase domain protein
HMPREF9154_RS08525	COG0640	Transcriptional regulator
HMPREF9154_RS08530	COG2814	Major facilitator Superfamily
HMPREF9154_RS08555	COG1131	(ABC) transporter
HMPREF9154_RS08570	COG1760	l-serine dehydratase
HMPREF9154_RS08575	COG2855	membrane
HMPREF9154_RS08580	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HMPREF9154_RS08590	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF9154_RS08590	COG0456	acetyltransferase
HMPREF9154_RS08635	COG2815	serine threonine protein kinase
HMPREF9154_RS08635	COG0515	serine threonine protein kinase
HMPREF9154_RS08655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HMPREF9154_RS08660	COG0113	porphobilinogen synthase activity
HMPREF9154_RS08670	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
HMPREF9154_RS08675	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HMPREF9154_RS08680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HMPREF9154_RS08685	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF9154_RS08690	COG3253	May function as heme-dependent peroxidase
HMPREF9154_RS08690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HMPREF9154_RS08715	COG0656	L-ascorbic acid biosynthetic process
HMPREF9154_RS08740	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF9154_RS08760	COG0799	negative regulation of ribosome biogenesis
HMPREF9154_RS08765	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HMPREF9154_RS08770	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HMPREF9154_RS08775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HMPREF9154_RS08780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HMPREF9154_RS08785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HMPREF9154_RS08790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HMPREF9154_RS08795	COG1530	ribonuclease E activity
HMPREF9154_RS08795	COG1530	ribonuclease E activity
HMPREF9154_RS08810	COG0285	dihydrofolate synthase activity
HMPREF9154_RS08825	COG0525	valine-tRNA ligase activity
HMPREF9154_RS08830	COG0793	Belongs to the peptidase S41A family
HMPREF9154_RS08830	COG4946	Tricorn protease homolog
HMPREF9154_RS08835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HMPREF9154_RS08840	COG0740	serine-type endopeptidase activity
HMPREF9154_RS08845	COG0740	serine-type endopeptidase activity
HMPREF9154_RS08855	COG0544	peptidyl-prolyl cis-trans isomerase activity
HMPREF9154_RS08860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9154_RS08880	COG1950	PFAM Membrane protein of
HMPREF9154_RS08910	COG0586	Pfam SNARE associated Golgi protein
HMPREF9154_RS08915	COG1349	DNA-binding transcription factor activity
HMPREF9154_RS08920	COG0698	ribose 5-phosphate isomerase
HMPREF9154_RS08930	COG0647	UMP catabolic process
HMPREF9154_RS08935	COG1070	Carbohydrate kinase
HMPREF9154_RS08940	COG0371	Dehydrogenase
HMPREF9154_RS08970	COG0701	Predicted permease
HMPREF9154_RS09000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HMPREF9154_RS09005	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HMPREF9154_RS09015	COG0540	Belongs to the ATCase OTCase family
HMPREF9154_RS09020	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HMPREF9154_RS09030	COG0477	Major facilitator Superfamily
HMPREF9154_RS09045	COG1201	RNA secondary structure unwinding
HMPREF9154_RS09060	COG0583	DNA-binding transcription factor activity
HMPREF9154_RS09070	COG1022	Amp-dependent synthetase and ligase
HMPREF9154_RS09080	COG0277	FAD linked oxidase domain protein
HMPREF9154_RS09120	COG2197	response regulator
HMPREF9154_RS09125	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HMPREF9154_RS09140	COG0556	nucleotide-excision repair
HMPREF9154_RS09145	COG0237	dephospho-CoA kinase activity
HMPREF9154_RS09155	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HMPREF9154_RS09160	COG0509	glycine decarboxylation via glycine cleavage system
HMPREF9154_RS09165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF9154_RS09165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HMPREF9154_RS09170	COG0539	negative regulation of cytoplasmic translation
HMPREF9154_RS09185	COG2050	protein possibly involved in aromatic compounds catabolism
HMPREF9154_RS09200	COG0469	pyruvate kinase activity
HMPREF9154_RS09210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HMPREF9154_RS09245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HMPREF9154_RS09250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HMPREF9154_RS09255	COG0772	Belongs to the SEDS family
HMPREF9154_RS09260	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HMPREF9154_RS09265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HMPREF9154_RS09270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HMPREF9154_RS09275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HMPREF9154_RS09280	COG0768	penicillin binding
HMPREF9154_RS09290	COG0275	rRNA processing
HMPREF9154_RS09295	COG2001	Belongs to the MraZ family
HMPREF9154_RS09300	COG0714	Associated with various cellular activities
HMPREF9154_RS09330	COG1615	UPF0182 protein
HMPREF9154_RS09340	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HMPREF9154_RS09380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9154_RS09390	COG1946	Acyl-CoA thioesterase
HMPREF9154_RS09395	COG1643	Atp-dependent helicase
HMPREF9154_RS09420	COG0129	dihydroxy-acid dehydratase activity
HMPREF9154_RS09430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HMPREF9154_RS09435	COG1333	cytochrome c biogenesis protein
HMPREF9154_RS09450	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HMPREF9154_RS09460	COG0710	3-dehydroquinate dehydratase activity
HMPREF9154_RS09465	COG1309	transcriptional regulator
HMPREF9154_RS09470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HMPREF9154_RS09480	COG0028	Belongs to the TPP enzyme family
HMPREF9154_RS09490	COG1012	belongs to the aldehyde dehydrogenase family
HMPREF9154_RS09495	COG0477	Major facilitator Superfamily
HMPREF9154_RS09500	COG1053	succinate dehydrogenase
HMPREF9154_RS09570	COG2337	Toxic component of a toxin-antitoxin (TA) module
HMPREF9154_RS09575	COG3609	addiction module antidote protein, CC2985 family
HMPREF9154_RS09580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HMPREF9154_RS09585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HMPREF9154_RS09595	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HMPREF9154_RS09600	COG0537	adenosine 5'-monophosphoramidase activity
HMPREF9154_RS09605	COG0107	imidazoleglycerol-phosphate synthase activity
HMPREF9154_RS09610	COG4581	dead DEAH box helicase
HMPREF9154_RS09620	COG0805	protein transport
HMPREF9154_RS09645	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_RS09660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HMPREF9154_RS09685	COG0494	nUDIX hydrolase
HMPREF9154_RS09705	COG1335	isochorismatase
HMPREF9154_RS09710	COG0497	DNA recombination
HMPREF9154_RS09715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HMPREF9154_RS09730	COG0647	UMP catabolic process
HMPREF9154_RS09755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HMPREF9154_RS09770	COG0165	Argininosuccinate lyase
HMPREF9154_RS09780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HMPREF9154_RS09785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HMPREF9154_RS09790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HMPREF9154_RS09795	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HMPREF9154_RS09800	COG0495	leucyl-tRNA aminoacylation
HMPREF9154_RS09810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HMPREF9154_RS09820	COG0072	phenylalanine-tRNA ligase activity
HMPREF9154_RS09820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HMPREF9154_RS09825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HMPREF9154_RS09835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HMPREF9154_RS09840	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HMPREF9154_RS09845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HMPREF9154_RS09855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS09860	COG1120	ATPase activity
HMPREF9154_RS09880	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HMPREF9154_RS09885	COG0140	phosphoribosyl-ATP diphosphatase activity
HMPREF9154_RS09890	COG0215	cysteine-tRNA ligase activity
HMPREF9154_RS09900	COG0667	Aldo Keto reductase
HMPREF9154_RS09915	COG0477	Major facilitator Superfamily
HMPREF9154_RS09930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HMPREF9154_RS09930	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HMPREF9154_RS09935	COG3973	AAA domain
HMPREF9154_RS09945	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_RS09950	COG0142	geranyltranstransferase activity
HMPREF9154_RS09965	COG1120	ATPase activity
HMPREF9154_RS09970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS09975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS09980	COG4592	Periplasmic binding protein
HMPREF9154_RS09990	COG2815	serine threonine protein kinase
HMPREF9154_RS09990	COG0515	serine threonine protein kinase
HMPREF9154_RS10010	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HMPREF9154_RS10015	COG2197	response regulator
HMPREF9154_RS10040	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HMPREF9154_RS10045	COG0088	Forms part of the polypeptide exit tunnel
HMPREF9154_RS10055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HMPREF9154_RS10100	COG0010	Belongs to the arginase family
HMPREF9154_RS10105	COG1132	(ABC) transporter
HMPREF9154_RS10110	COG4988	ABC transporter
HMPREF9154_RS10115	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HMPREF9154_RS10145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HMPREF9154_RS10150	COG0508	dehydrogenase complex catalyzes the overall conversion of
HMPREF9154_RS10155	COG0039	L-malate dehydrogenase activity
HMPREF9154_RS10165	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HMPREF9154_RS10170	COG0138	bifunctional purine biosynthesis protein purh
HMPREF9154_RS10180	COG0535	radical SAM domain protein
HMPREF9154_RS10205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HMPREF9154_RS10215	COG2197	response regulator
HMPREF9154_RS10220	COG2205	protein histidine kinase activity
HMPREF9154_RS10235	COG1983	PspC domain protein
HMPREF9154_RS10255	COG1129	ABC transporter
HMPREF9154_RS10260	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HMPREF9154_RS10270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HMPREF9154_RS10270	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_RS10300	COG2826	transposase and inactivated derivatives, IS30 family
HMPREF9154_RS10310	COG1120	ATPase activity
HMPREF9154_RS10315	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS10320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS10340	COG0516	GMP reductase activity
HMPREF9154_RS10350	COG2860	membrane
HMPREF9154_RS10355	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9154_RS10365	COG1486	melibiose metabolic process
HMPREF9154_RS10375	COG0459	protein refolding
HMPREF9154_RS10380	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HMPREF9154_RS10405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_RS10410	COG0601	transmembrane transport
HMPREF9154_RS10420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HMPREF9154_RS10430	COG0456	acetyltransferase
HMPREF9154_RS10430	COG1214	PFAM Peptidase M22, glycoprotease
HMPREF9154_RS10440	COG0513	Belongs to the DEAD box helicase family
HMPREF9154_RS10480	COG0736	holo-[acyl-carrier-protein] synthase activity
HMPREF9154_RS10485	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HMPREF9154_RS10490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HMPREF9154_RS10490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HMPREF9154_RS10495	COG1072	(Pantothenic acid kinase))
HMPREF9154_RS10500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HMPREF9154_RS10505	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HMPREF9154_RS10510	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HMPREF9154_RS10520	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HMPREF9154_RS10520	COG2169	Transcriptional regulator
HMPREF9154_RS10535	COG3304	Inner membrane component domain
HMPREF9154_RS10540	COG1120	ATPase activity
HMPREF9154_RS10545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS10555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HMPREF9154_RS10560	COG0101	tRNA pseudouridine synthase activity
HMPREF9154_RS10585	COG0601	transmembrane transport
HMPREF9154_RS10590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HMPREF9154_RS10595	COG0444	Belongs to the ABC transporter superfamily
HMPREF9154_RS10705	COG1674	ftsk spoiiie
HMPREF9154_RS10730	COG0203	ribosomal protein L17
HMPREF9154_RS10735	COG0202	RNA polymerase activity
HMPREF9154_RS10740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HMPREF9154_RS10745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HMPREF9154_RS10750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HMPREF9154_RS10755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HMPREF9154_RS10760	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HMPREF9154_RS10775	COG0024	Methionine aminopeptidase
HMPREF9154_RS10780	COG0563	adenylate kinase activity
HMPREF9154_RS10785	COG0201	protein transport
HMPREF9154_RS10790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HMPREF9154_RS10800	COG1841	ribosomal large subunit assembly
HMPREF9154_RS10805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HMPREF9154_RS10810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HMPREF9154_RS10815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HMPREF9154_RS10820	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HMPREF9154_RS10825	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HMPREF9154_RS10830	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HMPREF9154_RS10835	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HMPREF9154_RS10840	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HMPREF9154_RS10910	COG1528	Iron-storage protein
HMPREF9154_RS10925	COG0784	Response regulator, receiver
HMPREF9154_RS10925	COG2198	Histidine kinase
HMPREF9154_RS10925	COG2205	protein histidine kinase activity
HMPREF9154_RS10935	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HMPREF9154_RS10940	COG0255	Belongs to the universal ribosomal protein uL29 family
HMPREF9154_RS10945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HMPREF9154_RS10950	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HMPREF9154_RS10955	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HMPREF9154_RS10960	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HMPREF9154_RS10965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HMPREF9154_RS10970	COG0089	rRNA binding
HMPREF9154_RS10975	COG0088	Forms part of the polypeptide exit tunnel
HMPREF9154_RS10980	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HMPREF9154_RS10985	COG0051	transcription antitermination factor activity, RNA binding
HMPREF9154_RS11000	COG1136	(ABC) transporter
HMPREF9154_RS11010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_RS11020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HMPREF9154_RS11030	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HMPREF9154_RS11035	COG0698	ribose 5-phosphate isomerase
HMPREF9154_RS11045	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HMPREF9154_RS11050	COG0049	tRNA binding
HMPREF9154_RS11055	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HMPREF9154_RS11060	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HMPREF9154_RS11065	COG0085	RNA polymerase activity
HMPREF9154_RS11075	COG0222	ribosome binding
HMPREF9154_RS11080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HMPREF9154_RS11085	COG1132	(ABC) transporter
HMPREF9154_RS11090	COG1132	(ABC) transporter
HMPREF9154_RS11110	COG2378	regulation of single-species biofilm formation
HMPREF9154_RS11125	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9154_RS11130	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HMPREF9154_RS11135	COG0254	rRNA binding
HMPREF9154_RS11150	COG0081	regulation of translation
HMPREF9154_RS11155	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HMPREF9154_RS11160	COG0250	Participates in transcription elongation, termination and antitermination
HMPREF9154_RS11175	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HMPREF9154_RS11185	COG2030	dehydratase
HMPREF9154_RS11190	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HMPREF9154_RS11220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HMPREF9154_RS11225	COG3711	transcriptional antiterminator
HMPREF9154_RS11225	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HMPREF9154_RS11240	COG3732	PTS system glucitol sorbitol-specific
HMPREF9154_RS11250	COG0371	Dehydrogenase
HMPREF9154_RS11265	COG1131	(ABC) transporter
HMPREF9154_RS11295	COG0737	Belongs to the 5'-nucleotidase family
HMPREF9154_RS11305	COG2197	response regulator
HMPREF9154_RS11310	COG4585	Histidine kinase
HMPREF9154_RS11325	COG4585	Histidine kinase
HMPREF9154_RS11355	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS11355	COG1136	(ABC) transporter
HMPREF9154_RS11365	COG0359	binds to the 23S rRNA
HMPREF9154_RS11370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HMPREF9154_RS11380	COG0360	Binds together with S18 to 16S ribosomal RNA
HMPREF9154_RS11395	COG1136	(ABC) transporter
HMPREF9154_RS11395	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS11405	COG0778	Nitroreductase
HMPREF9154_RS11425	COG1022	Amp-dependent synthetase and ligase
HMPREF9154_RS11435	COG0789	Transcriptional regulator
HMPREF9154_RS11440	COG2190	(PTS) system
HMPREF9154_RS11440	COG2211	Major facilitator Superfamily
HMPREF9154_RS11445	COG0813	purine-nucleoside phosphorylase activity
HMPREF9154_RS11460	COG1666	GTP binding
HMPREF9154_RS11465	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HMPREF9154_RS11465	COG4106	trans-aconitate 2-methyltransferase activity
HMPREF9154_RS11475	COG2354	Protein conserved in bacteria
HMPREF9154_RS11480	COG0708	Exodeoxyribonuclease III
HMPREF9154_RS11490	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HMPREF9154_RS11490	COG0674	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_RS11495	COG1013	pyruvate-flavodoxin oxidoreductase activity
HMPREF9154_RS11530	COG0714	Associated with various cellular activities
HMPREF9154_RS11535	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HMPREF9154_RS11555	COG0142	geranyltranstransferase activity
HMPREF9154_RS11560	COG1007	ATP synthesis coupled electron transport
HMPREF9154_RS11575	COG0713	ATP synthesis coupled electron transport
HMPREF9154_RS11580	COG0839	Belongs to the complex I subunit 6 family
HMPREF9154_RS11585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_RS11590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HMPREF9154_RS11595	COG1034	ATP synthesis coupled electron transport
HMPREF9154_RS11600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HMPREF9154_RS11610	COG0649	NAD binding
HMPREF9154_RS11615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_RS11620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HMPREF9154_RS11635	COG1169	isochorismate synthase
HMPREF9154_RS11655	COG4133	protoheme IX ABC transporter activity
HMPREF9154_RS11665	COG2226	methyltransferase
HMPREF9154_RS11675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HMPREF9154_RS11680	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HMPREF9154_RS11690	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HMPREF9154_RS11695	COG4948	Mandelate Racemase Muconate Lactonizing
HMPREF9154_RS11715	COG1461	Dihydroxyacetone kinase
HMPREF9154_RS11725	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HMPREF9154_RS11745	COG2375	cellular response to nickel ion
HMPREF9154_RS11745	COG1132	(ABC) transporter
HMPREF9154_RS11750	COG1132	(ABC) transporter
HMPREF9154_RS11755	COG4166	transmembrane transport
HMPREF9154_RS11790	COG0640	Transcriptional regulator
HMPREF9154_RS11805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HMPREF9154_RS11810	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HMPREF9154_RS11865	COG0604	alcohol dehydrogenase
HMPREF9154_RS11865	COG3321	synthase
HMPREF9154_RS11865	COG1028	Short-chain dehydrogenase reductase Sdr
HMPREF9154_RS11870	COG1733	regulation of RNA biosynthetic process
HMPREF9154_RS11875	COG2197	response regulator
HMPREF9154_RS11880	COG4585	Histidine kinase
HMPREF9154_RS11885	COG1131	(ABC) transporter
HMPREF9154_RS11900	COG0667	Aldo Keto reductase
HMPREF9154_RS11925	COG2409	Drug exporters of the RND superfamily
HMPREF9154_RS11980	COG4585	Histidine kinase
HMPREF9154_RS11985	COG2197	response regulator
HMPREF9154_RS11990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HMPREF9154_RS11995	COG1136	(ABC) transporter
HMPREF9154_RS12000	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS12000	COG1136	(ABC) transporter
HMPREF9154_RS12020	COG1848	Toxic component of a toxin-antitoxin (TA) module. An RNase
HMPREF9154_RS12025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HMPREF9154_RS12040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HMPREF9154_RS12055	COG2056	Na+-H+ antiporter family
HMPREF9154_RS12060	COG0076	glutamate decarboxylase activity
HMPREF9154_RS12085	COG0515	serine threonine protein kinase
HMPREF9154_RS12100	COG0840	transmembrane signaling receptor activity
HMPREF9154_RS12115	COG2814	Major facilitator Superfamily
HMPREF9154_RS12140	COG0454	-acetyltransferase
HMPREF9154_RS12140	COG0456	acetyltransferase
HMPREF9154_RS12150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HMPREF9154_RS12155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_RS12160	COG0560	Phosphoserine phosphatase
HMPREF9154_RS12160	COG3830	Belongs to the UPF0237 family
HMPREF9154_RS12185	COG1473	amidohydrolase
HMPREF9154_RS12195	COG1464	Belongs to the NlpA lipoprotein family
HMPREF9154_RS12200	COG2011	ABC-type metal ion transport system permease component
HMPREF9154_RS12205	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HMPREF9154_RS12250	COG0166	Belongs to the GPI family
HMPREF9154_RS12285	COG2838	Isocitrate dehydrogenase
HMPREF9154_RS12290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HMPREF9154_RS12305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HMPREF9154_RS12310	COG3833	ABC-type maltose transport systems, permease component
HMPREF9154_RS12315	COG1175	transmembrane transport
HMPREF9154_RS12330	COG0366	Alpha amylase catalytic
HMPREF9154_RS12335	COG0789	Transcriptional regulator
HMPREF9154_RS12340	COG0484	heat shock protein binding
HMPREF9154_RS12345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HMPREF9154_RS12520	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HMPREF9154_RS12535	COG1970	mechanosensitive ion channel activity
HMPREF9154_RS12565	COG3226	Transcriptional regulator
HMPREF9154_RS12580	COG0281	malic enzyme
HMPREF9154_RS12600	COG0477	Major facilitator Superfamily
HMPREF9154_RS12610	COG0174	glutamine synthetase
HMPREF9154_RS12665	COG1234	tRNA 3'-trailer cleavage
HMPREF9154_RS12710	COG1309	transcriptional regulator
HMPREF9154_RS12715	COG0477	Major facilitator Superfamily
HMPREF9154_RS12755	COG4691	Plasmid stability protein
HMPREF9154_RS12765	COG4115	mRNA cleavage
HMPREF9154_RS12770	COG2161	toxin-antitoxin pair type II binding
HMPREF9154_RS12775	COG3226	Transcriptional regulator
HMPREF9154_RS12790	COG1733	regulation of RNA biosynthetic process
HMPREF9154_RS12820	COG0456	acetyltransferase
HMPREF9154_RS12845	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
HMPREF9154_RS12850	COG1396	sequence-specific DNA binding
HMPREF9154_RS12880	COG0012	GTP binding
HMPREF9154_RS12885	COG1362	aminopeptidase activity
HMPREF9154_RS12890	COG1322	Protein conserved in bacteria
HMPREF9154_RS12895	COG0813	purine-nucleoside phosphorylase activity
HMPREF9154_RS12940	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HMPREF9154_RS12955	COG1570	exodeoxyribonuclease VII activity
HMPREF9154_RS12960	COG1722	exodeoxyribonuclease VII activity
HMPREF9154_RS12975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HMPREF9154_RS12985	COG1774	PSP1 C-terminal conserved region
HMPREF9154_RS13005	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HMPREF9154_RS13010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HMPREF9154_RS13030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HMPREF9154_RS13030	COG1754	DNA topoisomerase type I activity
HMPREF9154_RS13070	COG1940	carbohydrate kinase activity
HMPREF9154_RS13075	COG1968	undecaprenyl-diphosphatase activity
HMPREF9154_RS13080	COG0385	Bile acid
HMPREF9154_RS13090	COG1621	beta-fructofuranosidase activity
HMPREF9154_RS13095	COG1136	(ABC) transporter
HMPREF9154_RS13110	COG0018	arginyl-trna synthetase
HMPREF9154_RS13115	COG0656	L-ascorbic acid biosynthetic process
HMPREF9154_RS13120	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HMPREF9154_RS13130	COG1216	Glycosyl transferase, family 2
HMPREF9154_RS13160	COG1716	ATPase activity
HMPREF9154_RS13180	COG0768	penicillin binding
HMPREF9154_RS13185	COG0515	serine threonine protein kinase
HMPREF9154_RS13210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HMPREF9154_RS13215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HMPREF9154_RS13245	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HMPREF9154_RS13250	COG1518	maintenance of DNA repeat elements
HMPREF9154_RS13250	COG1468	defense response to virus
HMPREF9154_RS13305	COG3263	regulation of cellular component size
HMPREF9154_RS13340	COG0438	transferase activity, transferring glycosyl groups
HMPREF9154_RS13345	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_RS13375	COG2027	D-alanyl-D-alanine carboxypeptidase
HMPREF9154_RS13380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HMPREF9154_RS13425	COG1136	(ABC) transporter
HMPREF9154_RS13425	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS13430	COG1136	(ABC) transporter
HMPREF9154_RS13430	COG0577	efflux transmembrane transporter activity
HMPREF9154_RS13445	COG1609	Transcriptional regulator
HMPREF9154_RS13455	COG2211	Major facilitator Superfamily
HMPREF9154_RS13460	COG1252	NADH dehydrogenase
HMPREF9154_RS13470	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HMPREF9154_RS13475	COG1116	anion transmembrane transporter activity
HMPREF9154_RS13500	COG0745	RESPONSE REGULATOR receiver
HMPREF9154_RS13505	COG2205	protein histidine kinase activity
HMPREF9154_RS13510	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HMPREF9154_RS13540	COG0318	PFAM AMP-dependent synthetase and ligase
HMPREF9154_RS13590	COG1129	ABC transporter
HMPREF9154_RS13605	COG1021	2,3-dihydroxybenzoate-AMP ligase
HMPREF9154_RS13610	COG1021	2,3-dihydroxybenzoate-AMP ligase
HMPREF9154_RS13615	COG2814	Major facilitator Superfamily
HMPREF9154_RS13625	COG1129	ABC transporter
HMPREF9154_RS13635	COG2375	cellular response to nickel ion
HMPREF9154_RS13635	COG1132	(ABC) transporter
HMPREF9154_RS13670	COG1132	(ABC) transporter
HMPREF9154_RS13685	COG0717	Belongs to the dCTP deaminase family
HMPREF9154_RS13715	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS13720	COG0601	transmembrane transport
HMPREF9154_RS13755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HMPREF9154_RS13770	COG0673	inositol 2-dehydrogenase activity
HMPREF9154_RS13790	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HMPREF9154_RS13805	COG1120	ATPase activity
HMPREF9154_RS13810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS13825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS13830	COG1120	ATPase activity
HMPREF9154_RS13845	COG0433	COG0433 Predicted ATPase
HMPREF9154_RS13860	COG2197	response regulator
HMPREF9154_RS13865	COG4585	Histidine kinase
HMPREF9154_RS13870	COG1131	(ABC) transporter
HMPREF9154_RS13895	COG1132	(ABC) transporter
HMPREF9154_RS13900	COG1132	(ABC) transporter
HMPREF9154_RS13905	COG1120	ATPase activity
HMPREF9154_RS13910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS13915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS13920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HMPREF9154_RS13945	COG0732	type I restriction modification DNA specificity domain
HMPREF9154_RS13950	COG1715	Restriction endonuclease
HMPREF9154_RS13960	COG3311	Transcriptional regulator
HMPREF9154_RS13990	COG5564	TIM-barrel signal transduction protein
HMPREF9154_RS14000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HMPREF9154_RS14005	COG3655	Transcriptional regulator
HMPREF9154_RS14015	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HMPREF9154_RS14030	COG1429	ligase activity, forming nitrogen-metal bonds
HMPREF9154_RS14035	COG1120	ATPase activity
HMPREF9154_RS14040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS14110	COG1175	transmembrane transport
HMPREF9154_RS14125	COG1621	beta-fructofuranosidase activity
HMPREF9154_RS14140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HMPREF9154_RS14150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HMPREF9154_RS14155	COG0584	glycerophosphoryl diester phosphodiesterase
HMPREF9154_RS14175	COG1316	TRANSCRIPTIONal
HMPREF9154_RS14205	COG0137	argininosuccinate synthase activity
HMPREF9154_RS14220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HMPREF9154_RS14230	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HMPREF9154_RS14255	COG1129	ABC transporter
HMPREF9154_RS14260	COG0667	Aldo Keto reductase
HMPREF9154_RS14265	COG0789	Transcriptional regulator
HMPREF9154_RS14290	COG4917	ethanolamine utilization protein
HMPREF9154_RS14345	COG4869	propanediol catabolic process
HMPREF9154_RS14360	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HMPREF9154_RS14375	COG0039	L-malate dehydrogenase activity
HMPREF9154_RS14440	COG1216	Glycosyl transferase, family 2
HMPREF9154_RS14440	COG0438	transferase activity, transferring glycosyl groups
HMPREF9154_RS14460	COG1215	transferase activity, transferring glycosyl groups
HMPREF9154_RS14595	COG1674	ftsk spoiiie
HMPREF9154_RS14645	COG0442	prolyl-tRNA aminoacylation
HMPREF9154_RS14655	COG0574	Belongs to the PEP-utilizing enzyme family
HMPREF9154_RS14655	COG3848	Pyruvate phosphate dikinase
HMPREF9154_RS14680	COG3588	fructose-bisphosphate aldolase
HMPREF9154_RS14745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HMPREF9154_RS14755	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_RS14760	COG1696	Membrane protein involved in D-alanine export
HMPREF9154_RS14770	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HMPREF9154_RS14780	COG0519	Catalyzes the synthesis of GMP from XMP
HMPREF9154_RS14790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HMPREF9154_RS14805	COG0733	neurotransmitter:sodium symporter activity
HMPREF9154_RS14810	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9154_RS14815	COG1408	metallophosphoesterase
HMPREF9154_RS14830	COG3012	SEC-C Motif Domain Protein
HMPREF9154_RS14905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HMPREF9154_RS14925	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HMPREF9154_RS14930	COG0653	protein targeting
HMPREF9154_RS14935	COG0315	cyclic pyranopterin monophosphate synthase activity
HMPREF9154_RS14935	COG0521	Mo-molybdopterin cofactor biosynthetic process
HMPREF9154_RS14965	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HMPREF9154_RS14980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HMPREF9154_RS14990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HMPREF9154_RS15055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HMPREF9154_RS15080	COG2856	Zn peptidase
HMPREF9154_RS15110	COG0768	penicillin binding
HMPREF9154_RS15120	COG3527	Alpha-acetolactate decarboxylase
HMPREF9154_RS15135	COG1120	ATPase activity
HMPREF9154_RS15140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS15145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HMPREF9154_RS15155	COG0783	Belongs to the Dps family
HMPREF9154_RS15160	COG2267	carboxylic ester hydrolase activity
HMPREF9154_RS15190	COG1321	iron dependent repressor
HMPREF9154_RS15195	COG1971	Probably functions as a manganese efflux pump
HMPREF9154_RS15205	COG1024	Enoyl-CoA hydratase
HMPREF9154_RS15210	COG1505	serine-type exopeptidase activity
HMPREF9154_RS15235	COG0492	ferredoxin-NADP+ reductase activity
HMPREF9154_RS15255	COG1181	Belongs to the D-alanine--D-alanine ligase family
HMPREF9154_RS15280	COG0357	Ribosomal RNA small subunit methyltransferase G
HMPREF9154_RS15290	COG0706	membrane insertase activity
HMPREF9154_RS15295	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HMPREF9154_RS15300	COG0594	ribonuclease P activity
HMPREF9154_RS15305	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HMPREF9154_RS15455	COG0156	8-amino-7-oxononanoate synthase activity
HMPREF9154_RS15500	COG0246	Mannitol dehydrogenase
HMPREF9154_RS15505	COG0189	ligase activity
HMPREF9154_RS15515	COG4221	oxidoreductase activity
HMPREF9154_RS15515	COG3321	synthase
HMPREF9154_RS15515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS15515	COG0300	oxidoreductase activity
HMPREF9154_RS15520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HMPREF9154_RS15520	COG4221	oxidoreductase activity
HMPREF9154_RS15520	COG3321	synthase
HMPREF9154_RS15520	COG0300	oxidoreductase activity
HMPREF9154_RS15525	COG0604	alcohol dehydrogenase
HMPREF9154_RS15525	COG3321	synthase
HMPREF9154_RS15535	COG0741	lytic transglycosylase activity
HMPREF9154_RS15535	COG1196	nuclear chromosome segregation
HMPREF9154_RS15535	COG0739	heme binding
HMPREF9154_RS15565	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HMPREF9154_RS15580	COG4585	Histidine kinase
HMPREF9154_RS15585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HMPREF9154_RS15610	COG1408	metallophosphoesterase
HMPREF9154_RS15675	COG3226	Transcriptional regulator
HMPREF9154_RS15775	COG3177	Filamentation induced by cAMP protein fic
HMPREF9154_RS15830	COG3433	isochorismatase activity
HMPREF9154_RS15830	COG2226	methyltransferase
HMPREF9154_RS15830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HMPREF9154_RS15875	COG0791	NLP P60 protein
HMPREF9154_RS15875	COG3883	PFAM NLP P60 protein
HMPREF9154_RS15920	COG0746	molybdenum cofactor guanylyltransferase activity
HMPREF9154_RS15945	COG1476	TRANSCRIPTIONal
HMPREF9154_RS15970	COG0181	hydroxymethylbilane synthase activity
HMPREF9154_RS15975	COG1799	cell septum assembly
HMPREF9154_RS15980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HMPREF9154_RS15985	COG0802	atpase or kinase