locus-tag	class	description
EOK75_RS00005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EOK75_RS00010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS00015	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS00020	COG4597	amino acid ABC transporter
EOK75_RS00025	COG0765	amino acid transport
EOK75_RS00030	COG1126	abc transporter atp-binding protein
EOK75_RS00050	COG0028	Belongs to the TPP enzyme family
EOK75_RS00055	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS00060	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS00065	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS00070	COG0747	negative chemotaxis
EOK75_RS00075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS00080	COG0601	transmembrane transport
EOK75_RS00100	COG0210	DNA helicase
EOK75_RS00110	COG2207	Transcriptional regulator
EOK75_RS00150	COG0411	ABC transporter
EOK75_RS00165	COG1024	Enoyl-CoA hydratase
EOK75_RS00165	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS00190	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS00195	COG1024	Enoyl-CoA hydratase
EOK75_RS00195	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS00215	COG0183	Belongs to the thiolase family
EOK75_RS00225	COG3920	Histidine kinase
EOK75_RS00250	COG0697	spore germination
EOK75_RS00265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EOK75_RS00270	COG0028	Belongs to the TPP enzyme family
EOK75_RS00285	COG0747	negative chemotaxis
EOK75_RS00290	COG0601	transmembrane transport
EOK75_RS00295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS00310	COG2197	response regulator
EOK75_RS00330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EOK75_RS00370	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS00375	COG0473	3-isopropylmalate dehydrogenase activity
EOK75_RS00385	COG2084	Dehydrogenase
EOK75_RS00400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS00410	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS00425	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EOK75_RS00495	COG2133	pyrroloquinoline quinone binding
EOK75_RS00525	COG0789	Transcriptional regulator
EOK75_RS00550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EOK75_RS00610	COG0732	type I restriction modification DNA specificity domain
EOK75_RS00635	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EOK75_RS00660	COG4770	biotin carboxylase activity
EOK75_RS00670	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EOK75_RS00670	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EOK75_RS00685	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EOK75_RS00695	COG0248	Ppx GppA phosphatase
EOK75_RS00700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EOK75_RS00710	COG0628	permease
EOK75_RS00715	COG0442	prolyl-tRNA aminoacylation
EOK75_RS00730	COG1136	(ABC) transporter
EOK75_RS00745	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EOK75_RS00755	COG0534	Mate efflux family protein
EOK75_RS00760	COG2326	polyphosphate kinase activity
EOK75_RS00765	COG0187	DNA topoisomerase II activity
EOK75_RS00785	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EOK75_RS00810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EOK75_RS00815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EOK75_RS00835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EOK75_RS00850	COG0544	peptidyl-prolyl cis-trans isomerase activity
EOK75_RS00860	COG0359	binds to the 23S rRNA
EOK75_RS00865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EOK75_RS00870	COG0360	Binds together with S18 to 16S ribosomal RNA
EOK75_RS00875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
EOK75_RS00885	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EOK75_RS00920	COG0747	negative chemotaxis
EOK75_RS00935	COG0528	UMP kinase activity
EOK75_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS00965	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EOK75_RS00995	COG0745	RESPONSE REGULATOR receiver
EOK75_RS01000	COG2205	protein histidine kinase activity
EOK75_RS01015	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EOK75_RS01020	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EOK75_RS01095	COG5001	Diguanylate cyclase
EOK75_RS01095	COG3300	MHYT domain
EOK75_RS01140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EOK75_RS01145	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EOK75_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS01155	COG0579	oxidoreductase
EOK75_RS01175	COG1288	antiporter activity
EOK75_RS01180	COG2235	arginine
EOK75_RS01220	COG0604	alcohol dehydrogenase
EOK75_RS01245	COG0318	PFAM AMP-dependent synthetase and ligase
EOK75_RS01265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EOK75_RS01295	COG1414	Transcriptional regulator
EOK75_RS01330	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS01350	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS01355	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS01365	COG0601	transmembrane transport
EOK75_RS01385	COG1802	Transcriptional regulator
EOK75_RS01390	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS01410	COG3547	Transposase (IS116 IS110 IS902 family)
EOK75_RS01420	COG3706	GGDEF domain
EOK75_RS01445	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EOK75_RS01450	COG1172	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS01465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS01470	COG0765	amino acid transport
EOK75_RS01475	COG1126	abc transporter atp-binding protein
EOK75_RS01495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EOK75_RS01500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EOK75_RS01515	COG4695	Portal protein
EOK75_RS01615	COG0508	dehydrogenase complex catalyzes the overall conversion of
EOK75_RS01620	COG0508	dehydrogenase complex catalyzes the overall conversion of
EOK75_RS01620	COG0022	dehydrogenase e1 component
EOK75_RS01625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EOK75_RS01635	COG3588	fructose-bisphosphate aldolase
EOK75_RS01640	COG0126	phosphoglycerate kinase activity
EOK75_RS01655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EOK75_RS01660	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EOK75_RS01675	COG0697	spore germination
EOK75_RS01690	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EOK75_RS01755	COG3920	Histidine kinase
EOK75_RS01785	COG3237	CsbD-like
EOK75_RS01850	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS01855	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS01860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS01870	COG0747	negative chemotaxis
EOK75_RS01880	COG4948	Mandelate Racemase Muconate Lactonizing
EOK75_RS01900	COG2855	membrane
EOK75_RS01905	COG0583	DNA-binding transcription factor activity
EOK75_RS01910	COG0251	oxidation-reduction process
EOK75_RS01920	COG4215	(ABC) transporter
EOK75_RS01925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS01940	COG3383	formate dehydrogenase (NAD+) activity
EOK75_RS01950	COG0583	DNA-binding transcription factor activity
EOK75_RS02045	COG4974	Belongs to the 'phage' integrase family
EOK75_RS02050	COG0517	IMP dehydrogenase activity
EOK75_RS02055	COG1288	antiporter activity
EOK75_RS02085	COG3547	Transposase (IS116 IS110 IS902 family)
EOK75_RS02135	COG1201	RNA secondary structure unwinding
EOK75_RS02140	COG1793	dna ligase
EOK75_RS02175	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS02195	COG2963	transposase activity
EOK75_RS02215	COG1573	uracil-dna glycosylase
EOK75_RS02245	COG1285	pathogenesis
EOK75_RS02250	COG4529	Protein conserved in bacteria
EOK75_RS02255	COG0753	catalase activity
EOK75_RS02290	COG2353	YceI-like domain
EOK75_RS02330	COG3685	Protein conserved in bacteria
EOK75_RS02350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS02365	COG0747	negative chemotaxis
EOK75_RS02370	COG0601	transmembrane transport
EOK75_RS02375	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS02380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EOK75_RS02385	COG0277	FAD linked oxidase domain protein
EOK75_RS02420	COG2031	fatty acid transporter
EOK75_RS02445	COG0811	peptide transport
EOK75_RS02450	COG4604	ABC transporter, ATP-binding protein
EOK75_RS02455	COG4605	iron ion homeostasis
EOK75_RS02460	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EOK75_RS02465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EOK75_RS02475	COG1309	transcriptional regulator
EOK75_RS02480	COG0625	glutathione transferase activity
EOK75_RS02485	COG0625	glutathione transferase activity
EOK75_RS02505	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EOK75_RS02510	COG2011	ABC-type metal ion transport system permease component
EOK75_RS02515	COG1464	Belongs to the NlpA lipoprotein family
EOK75_RS02520	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
EOK75_RS02535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EOK75_RS02540	COG0730	response to heat
EOK75_RS02550	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EOK75_RS02555	COG4235	cytochrome complex assembly
EOK75_RS02560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS02575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EOK75_RS02575	COG0446	pyridine nucleotide-disulphide oxidoreductase
EOK75_RS02590	COG5265	(ABC) transporter
EOK75_RS02600	COG0411	ABC transporter
EOK75_RS02605	COG1172	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS02610	COG0559	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS02625	COG1215	transferase activity, transferring glycosyl groups
EOK75_RS02635	COG0488	(ABC) transporter
EOK75_RS02640	COG0105	UTP biosynthetic process
EOK75_RS02645	COG0488	(ABC) transporter
EOK75_RS02660	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EOK75_RS02665	COG0215	cysteine-tRNA ligase activity
EOK75_RS02670	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EOK75_RS02680	COG2951	lytic endotransglycosylase activity
EOK75_RS02685	COG2814	Major facilitator Superfamily
EOK75_RS02740	COG0433	COG0433 Predicted ATPase
EOK75_RS02750	COG5598	trimethylamine methyltransferase
EOK75_RS02765	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EOK75_RS02770	COG2010	Cytochrome c
EOK75_RS02785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
EOK75_RS02790	COG2867	negative regulation of translational initiation
EOK75_RS02795	COG1546	Belongs to the CinA family
EOK75_RS02810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EOK75_RS02815	COG3852	Histidine kinase
EOK75_RS02820	COG2204	response regulator
EOK75_RS02830	COG2204	response regulator
EOK75_RS02835	COG0569	domain protein
EOK75_RS02840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EOK75_RS02845	COG1923	regulation of RNA biosynthetic process
EOK75_RS02850	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EOK75_RS02870	COG0640	Transcriptional regulator
EOK75_RS02875	COG0047	phosphoribosylformylglycinamidine synthase activity
EOK75_RS02920	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EOK75_RS02930	COG1561	YicC-like family, N-terminal region
EOK75_RS02935	COG0194	GDP metabolic process
EOK75_RS02945	COG2089	acid synthase
EOK75_RS02995	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EOK75_RS03025	COG4536	flavin adenine dinucleotide binding
EOK75_RS03030	COG4974	Belongs to the 'phage' integrase family
EOK75_RS03040	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EOK75_RS03120	COG0604	alcohol dehydrogenase
EOK75_RS03130	COG0583	DNA-binding transcription factor activity
EOK75_RS03140	COG1522	sequence-specific DNA binding
EOK75_RS03160	COG2081	HI0933 family
EOK75_RS03175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EOK75_RS03190	COG2313	pseudouridylate synthase activity
EOK75_RS03210	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS03215	COG4166	transmembrane transport
EOK75_RS03230	COG2814	Major facilitator Superfamily
EOK75_RS03235	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EOK75_RS03255	COG2084	Dehydrogenase
EOK75_RS03265	COG0546	phosphoglycolate phosphatase activity
EOK75_RS03270	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EOK75_RS03285	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EOK75_RS03295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EOK75_RS03310	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
EOK75_RS03330	COG3483	tryptophan 2,3-dioxygenase activity
EOK75_RS03335	COG1376	ErfK ybiS ycfS ynhG family protein
EOK75_RS03340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EOK75_RS03360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EOK75_RS03365	COG1132	(ABC) transporter
EOK75_RS03370	COG0354	folic acid binding
EOK75_RS03375	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EOK75_RS03395	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EOK75_RS03405	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
EOK75_RS03410	COG0408	coproporphyrinogen oxidase activity
EOK75_RS03420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EOK75_RS03425	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EOK75_RS03430	COG1388	LysM domain
EOK75_RS03430	COG0739	heme binding
EOK75_RS03440	COG0805	protein transport
EOK75_RS03450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EOK75_RS03460	COG3842	ATPase activity
EOK75_RS03475	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS03485	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EOK75_RS03500	COG0513	Belongs to the DEAD box helicase family
EOK75_RS03520	COG1007	ATP synthesis coupled electron transport
EOK75_RS03555	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EOK75_RS03595	COG0649	NAD binding
EOK75_RS03600	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EOK75_RS03605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EOK75_RS03625	COG4770	biotin carboxylase activity
EOK75_RS03630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EOK75_RS03635	COG3047	cAMP biosynthetic process
EOK75_RS03640	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS03645	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EOK75_RS03650	COG0405	Gamma-glutamyltransferase
EOK75_RS03655	COG2391	methyltransferase activity
EOK75_RS03665	COG0747	negative chemotaxis
EOK75_RS03675	COG0601	transmembrane transport
EOK75_RS03680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS03685	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS03690	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS03695	COG1652	LysM domain
EOK75_RS03700	COG4681	YaeQ
EOK75_RS03725	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EOK75_RS03735	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
EOK75_RS03740	COG0436	Aminotransferase
EOK75_RS03750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EOK75_RS03770	COG0134	indole-3-glycerol-phosphate synthase activity
EOK75_RS03785	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EOK75_RS03790	COG0658	competence protein
EOK75_RS03790	COG2333	competence protein COMEC
EOK75_RS03795	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EOK75_RS03800	COG0372	Belongs to the citrate synthase family
EOK75_RS03840	COG2943	transferase activity, transferring hexosyl groups
EOK75_RS03845	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
EOK75_RS03855	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EOK75_RS03855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS03860	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EOK75_RS03865	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EOK75_RS03875	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS03880	COG3246	L-lysine catabolic process to acetate
EOK75_RS03890	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EOK75_RS03895	COG1127	ABC transporter
EOK75_RS03910	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EOK75_RS03960	COG4974	Belongs to the 'phage' integrase family
EOK75_RS03965	COG0517	IMP dehydrogenase activity
EOK75_RS03980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EOK75_RS03995	COG1309	transcriptional regulator
EOK75_RS04020	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EOK75_RS04070	COG0024	Methionine aminopeptidase
EOK75_RS04115	COG0765	amino acid transport
EOK75_RS04120	COG1126	abc transporter atp-binding protein
EOK75_RS04130	COG0625	glutathione transferase activity
EOK75_RS04135	COG0583	DNA-binding transcription factor activity
EOK75_RS04145	COG1175	transmembrane transport
EOK75_RS04150	COG0395	ABC-type sugar transport system, permease component
EOK75_RS04155	COG3842	ATPase activity
EOK75_RS04165	COG1187	pseudouridine synthase activity
EOK75_RS04170	COG0483	inositol monophosphate 1-phosphatase activity
EOK75_RS04200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EOK75_RS04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EOK75_RS04215	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EOK75_RS04220	COG4133	protoheme IX ABC transporter activity
EOK75_RS04240	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EOK75_RS04260	COG2166	iron-sulfur cluster assembly
EOK75_RS04280	COG3800	Transcriptional regulator
EOK75_RS04280	COG1396	sequence-specific DNA binding
EOK75_RS04300	COG0114	fumarate hydratase activity
EOK75_RS04315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EOK75_RS04325	COG0318	PFAM AMP-dependent synthetase and ligase
EOK75_RS04345	COG0574	Belongs to the PEP-utilizing enzyme family
EOK75_RS04345	COG3848	Pyruvate phosphate dikinase
EOK75_RS04420	COG0581	inorganic phosphate transmembrane transporter activity
EOK75_RS04425	COG0573	inorganic phosphate transmembrane transporter activity
EOK75_RS04430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EOK75_RS04435	COG5002	protein histidine kinase activity
EOK75_RS04445	COG0745	RESPONSE REGULATOR receiver
EOK75_RS04480	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EOK75_RS04490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EOK75_RS04495	COG0849	cell division
EOK75_RS04500	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EOK75_RS04505	COG1181	Belongs to the D-alanine--D-alanine ligase family
EOK75_RS04520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EOK75_RS04540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EOK75_RS04550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EOK75_RS04575	COG0489	protein tyrosine kinase activity
EOK75_RS04585	COG0210	DNA helicase
EOK75_RS04590	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EOK75_RS04625	COG1780	Probably involved in ribonucleotide reductase function
EOK75_RS04630	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EOK75_RS04635	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EOK75_RS04650	COG0564	pseudouridine synthase activity
EOK75_RS04665	COG3842	ATPase activity
EOK75_RS04670	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS04675	COG1177	transmembrane transport
EOK75_RS04695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EOK75_RS04700	COG0330	HflC and HflK could
EOK75_RS04705	COG0330	HflC and HflK could
EOK75_RS04720	COG1760	l-serine dehydratase
EOK75_RS04740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EOK75_RS04745	COG1121	(ABC) transporter
EOK75_RS04775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EOK75_RS04795	COG0768	penicillin binding
EOK75_RS04800	COG0772	Belongs to the SEDS family
EOK75_RS04805	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EOK75_RS04810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS04835	COG0071	Belongs to the small heat shock protein (HSP20) family
EOK75_RS04845	COG0247	lactate metabolic process
EOK75_RS04850	COG0277	FAD linked oxidase domain protein
EOK75_RS04855	COG0277	FAD linked oxidase domain protein
EOK75_RS04875	COG0714	Associated with various cellular activities
EOK75_RS04890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EOK75_RS04890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
EOK75_RS04900	COG0583	DNA-binding transcription factor activity
EOK75_RS04915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EOK75_RS04920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EOK75_RS04920	COG0517	IMP dehydrogenase activity
EOK75_RS04935	COG0471	metal ion transport
EOK75_RS04935	COG3273	potassium ion transport
EOK75_RS04940	COG1692	metallophosphoesterase
EOK75_RS04950	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EOK75_RS04960	COG2759	Belongs to the formate--tetrahydrofolate ligase family
EOK75_RS04965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EOK75_RS04970	COG0037	tRNA processing
EOK75_RS04980	COG2885	chlorophyll binding
EOK75_RS04995	COG0848	biopolymer transport protein
EOK75_RS05005	COG0824	Thioesterase
EOK75_RS05015	COG2255	four-way junction helicase activity
EOK75_RS05025	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EOK75_RS05050	COG2391	methyltransferase activity
EOK75_RS05055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS05060	COG1442	glycosyl transferase family 8
EOK75_RS05080	COG4974	Belongs to the 'phage' integrase family
EOK75_RS05085	COG1183	phosphatidylcholine synthase activity
EOK75_RS05095	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EOK75_RS05100	COG3768	UPF0283 membrane protein
EOK75_RS05105	COG3106	COG3106 Predicted ATPase
EOK75_RS05110	COG0101	tRNA pseudouridine synthase activity
EOK75_RS05115	COG2176	DNA-directed DNA polymerase activity
EOK75_RS05115	COG5002	protein histidine kinase activity
EOK75_RS05120	COG0745	RESPONSE REGULATOR receiver
EOK75_RS05135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EOK75_RS05150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EOK75_RS05160	COG1703	isobutyryl-CoA mutase activity
EOK75_RS05170	COG1643	Atp-dependent helicase
EOK75_RS05180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EOK75_RS05225	COG1477	protein flavinylation
EOK75_RS05290	COG5002	protein histidine kinase activity
EOK75_RS05310	COG0594	ribonuclease P activity
EOK75_RS05315	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EOK75_RS05340	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EOK75_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS05360	COG1126	abc transporter atp-binding protein
EOK75_RS05365	COG0765	amino acid transport
EOK75_RS05370	COG4597	amino acid ABC transporter
EOK75_RS05375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS05385	COG0564	pseudouridine synthase activity
EOK75_RS05395	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EOK75_RS05400	COG3916	Acyl-homoserine-lactone synthase
EOK75_RS05420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EOK75_RS05425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EOK75_RS05430	COG0563	adenylate kinase activity
EOK75_RS05450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EOK75_RS05455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EOK75_RS05460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EOK75_RS05480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EOK75_RS05495	COG0255	Belongs to the universal ribosomal protein uL29 family
EOK75_RS05505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EOK75_RS05510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EOK75_RS05520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EOK75_RS05525	COG0089	rRNA binding
EOK75_RS05530	COG0088	Forms part of the polypeptide exit tunnel
EOK75_RS05535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EOK75_RS05540	COG0051	transcription antitermination factor activity, RNA binding
EOK75_RS05545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EOK75_RS05560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EOK75_RS05565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EOK75_RS05575	COG0222	ribosome binding
EOK75_RS05580	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EOK75_RS05585	COG0081	regulation of translation
EOK75_RS05595	COG0250	Participates in transcription elongation, termination and antitermination
EOK75_RS05610	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EOK75_RS05620	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EOK75_RS05650	COG1522	sequence-specific DNA binding
EOK75_RS05660	COG1126	abc transporter atp-binding protein
EOK75_RS05665	COG0765	amino acid transport
EOK75_RS05670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS05675	COG0765	amino acid transport
EOK75_RS05680	COG0425	Belongs to the sulfur carrier protein TusA family
EOK75_RS05685	COG0746	molybdenum cofactor guanylyltransferase activity
EOK75_RS05700	COG1295	ribonuclease BN
EOK75_RS05710	COG0729	surface antigen
EOK75_RS05715	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EOK75_RS05760	COG1815	bacterial-type flagellum-dependent cell motility
EOK75_RS05765	COG1558	bacterial-type flagellum-dependent cell motility
EOK75_RS05770	COG1677	Flagellar hook-basal body complex protein FliE
EOK75_RS05775	COG1987	bacterial-type flagellum assembly
EOK75_RS05780	COG4786	Flagellar basal body rod
EOK75_RS05785	COG4786	Flagellar basal body rod
EOK75_RS05795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
EOK75_RS05810	COG2226	methyltransferase
EOK75_RS05815	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EOK75_RS05820	COG1024	Enoyl-CoA hydratase
EOK75_RS05840	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EOK75_RS05965	COG0517	IMP dehydrogenase activity
EOK75_RS05970	COG4974	Belongs to the 'phage' integrase family
EOK75_RS05980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EOK75_RS05985	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EOK75_RS05990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EOK75_RS06040	COG2963	transposase activity
EOK75_RS06045	COG3436	PFAM IS66 Orf2 family protein
EOK75_RS06055	COG3012	SEC-C Motif Domain Protein
EOK75_RS06095	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
EOK75_RS06120	COG0022	dehydrogenase e1 component
EOK75_RS06130	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS06135	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EOK75_RS06140	COG0277	FAD linked oxidase domain protein
EOK75_RS06145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EOK75_RS06150	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS06165	COG0559	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS06180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EOK75_RS06180	COG0604	alcohol dehydrogenase
EOK75_RS06180	COG4221	oxidoreductase activity
EOK75_RS06180	COG3321	synthase
EOK75_RS06185	COG1802	Transcriptional regulator
EOK75_RS06190	COG2801	Transposase and inactivated derivatives
EOK75_RS06220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EOK75_RS06230	COG1116	anion transmembrane transporter activity
EOK75_RS06235	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EOK75_RS06240	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EOK75_RS06245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EOK75_RS06255	COG2022	thiamine diphosphate biosynthetic process
EOK75_RS06270	COG0351	phosphomethylpyrimidine kinase
EOK75_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EOK75_RS06310	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS06315	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS06320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS06330	COG0747	negative chemotaxis
EOK75_RS06345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EOK75_RS06410	COG1126	abc transporter atp-binding protein
EOK75_RS06415	COG0765	amino acid transport
EOK75_RS06420	COG0765	amino acid transport
EOK75_RS06480	COG0446	pyridine nucleotide-disulphide oxidoreductase
EOK75_RS06480	COG1902	pentaerythritol trinitrate reductase activity
EOK75_RS06505	COG3550	peptidyl-serine autophosphorylation
EOK75_RS06510	COG1396	sequence-specific DNA binding
EOK75_RS06570	COG0747	negative chemotaxis
EOK75_RS06580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS06585	COG0601	transmembrane transport
EOK75_RS06640	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS06645	COG1177	transmembrane transport
EOK75_RS06650	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS06660	COG3842	ATPase activity
EOK75_RS06665	COG3246	L-lysine catabolic process to acetate
EOK75_RS06675	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS06680	COG1024	Enoyl-CoA hydratase
EOK75_RS06685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EOK75_RS06690	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS06700	COG2267	carboxylic ester hydrolase activity
EOK75_RS06725	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS06775	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EOK75_RS06785	COG0626	cystathionine gamma-synthase activity
EOK75_RS06795	COG1522	sequence-specific DNA binding
EOK75_RS06845	COG0583	DNA-binding transcription factor activity
EOK75_RS07015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EOK75_RS07055	COG4191	Histidine kinase
EOK75_RS07070	COG0666	response to abiotic stimulus
EOK75_RS07085	COG0768	penicillin binding
EOK75_RS07100	COG2010	Cytochrome c
EOK75_RS07125	COG1238	metal cluster binding
EOK75_RS07130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EOK75_RS07135	COG2205	protein histidine kinase activity
EOK75_RS07160	COG0398	Pfam SNARE associated Golgi protein
EOK75_RS07185	COG2814	Major facilitator Superfamily
EOK75_RS07200	COG2132	Multicopper oxidase
EOK75_RS07210	COG0582	viral genome integration into host DNA
EOK75_RS07265	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EOK75_RS07275	COG2856	Zn peptidase
EOK75_RS07345	COG0583	DNA-binding transcription factor activity
EOK75_RS07350	COG3781	membrane
EOK75_RS07390	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EOK75_RS07400	COG0303	'Molybdopterin
EOK75_RS07405	COG0243	molybdopterin cofactor binding
EOK75_RS07415	COG2198	Histidine kinase
EOK75_RS07415	COG0784	Response regulator, receiver
EOK75_RS07415	COG2205	protein histidine kinase activity
EOK75_RS07430	COG1999	signal sequence binding
EOK75_RS07450	COG0789	Transcriptional regulator
EOK75_RS07495	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EOK75_RS07500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EOK75_RS07530	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EOK75_RS07555	COG0180	Tryptophanyl-tRNA synthetase
EOK75_RS07560	COG0443	Heat shock 70 kDa protein
EOK75_RS07580	COG0450	alkyl hydroperoxide reductase
EOK75_RS07585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EOK75_RS07600	COG1185	polyribonucleotide nucleotidyltransferase activity
EOK75_RS07625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EOK75_RS07630	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EOK75_RS07640	COG1715	Restriction endonuclease
EOK75_RS07645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EOK75_RS07650	COG0142	geranyltranstransferase activity
EOK75_RS07655	COG1722	exodeoxyribonuclease VII activity
EOK75_RS07660	COG0123	including yeast histone deacetylase and acetoin utilization protein
EOK75_RS07665	COG0745	RESPONSE REGULATOR receiver
EOK75_RS07670	COG1846	Transcriptional regulator
EOK75_RS07685	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EOK75_RS07690	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
EOK75_RS07695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EOK75_RS07700	COG1137	ATPase activity
EOK75_RS07705	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EOK75_RS07720	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EOK75_RS07735	COG1663	tetraacyldisaccharide 4'-kinase activity
EOK75_RS07755	COG0072	phenylalanine-tRNA ligase activity
EOK75_RS07755	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EOK75_RS07765	COG0640	Transcriptional regulator
EOK75_RS07775	COG0785	Cytochrome C biogenesis protein
EOK75_RS07800	COG3258	Cytochrome c
EOK75_RS07805	COG0737	Belongs to the 5'-nucleotidase family
EOK75_RS07810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EOK75_RS07820	COG2863	cytochrome
EOK75_RS07825	COG0446	pyridine nucleotide-disulphide oxidoreductase
EOK75_RS07860	COG1366	Belongs to the anti-sigma-factor antagonist family
EOK75_RS07870	COG0405	Gamma-glutamyltransferase
EOK75_RS07875	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EOK75_RS07885	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EOK75_RS07900	COG0469	pyruvate kinase activity
EOK75_RS07915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EOK75_RS07925	COG1194	a g-specific adenine glycosylase
EOK75_RS07940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EOK75_RS07955	COG0019	diaminopimelate decarboxylase activity
EOK75_RS07990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
EOK75_RS08010	COG0495	leucyl-tRNA aminoacylation
EOK75_RS08030	COG2081	HI0933 family
EOK75_RS08040	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EOK75_RS08070	COG3246	L-lysine catabolic process to acetate
EOK75_RS08075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EOK75_RS08085	COG0765	amino acid transport
EOK75_RS08090	COG0765	amino acid transport
EOK75_RS08095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS08100	COG0583	DNA-binding transcription factor activity
EOK75_RS08110	COG1346	cytolysis
EOK75_RS08125	COG0583	DNA-binding transcription factor activity
EOK75_RS08130	COG2423	ornithine cyclodeaminase activity
EOK75_RS08135	COG3616	Alanine racemase, N-terminal domain
EOK75_RS08140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EOK75_RS08145	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EOK75_RS08150	COG1414	Transcriptional regulator
EOK75_RS08155	COG1338	Plays a role in the flagellum-specific transport system
EOK75_RS08160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EOK75_RS08170	COG1766	The M ring may be actively involved in energy transduction
EOK75_RS08190	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EOK75_RS08210	COG2373	Large extracellular alpha-helical protein
EOK75_RS08215	COG4953	penicillin-binding protein 1C
EOK75_RS08220	COG0183	Belongs to the thiolase family
EOK75_RS08230	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EOK75_RS08245	COG3550	peptidyl-serine autophosphorylation
EOK75_RS08285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EOK75_RS08325	COG2226	methyltransferase
EOK75_RS08335	COG0318	PFAM AMP-dependent synthetase and ligase
EOK75_RS08375	COG4771	TonB-dependent receptor
EOK75_RS08380	COG1120	ATPase activity
EOK75_RS08385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EOK75_RS08390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EOK75_RS08395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EOK75_RS08425	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EOK75_RS08445	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EOK75_RS08480	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EOK75_RS08485	COG1674	ftsk spoiiie
EOK75_RS08490	COG0436	Aminotransferase
EOK75_RS08495	COG0154	amidase activity
EOK75_RS08500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EOK75_RS08520	COG0312	modulator of DNA gyrase
EOK75_RS08525	COG1218	3'(2'),5'-bisphosphate nucleotidase
EOK75_RS08540	COG2835	tetraacyldisaccharide 4'-kinase activity
EOK75_RS08545	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
EOK75_RS08550	COG3830	Belongs to the UPF0237 family
EOK75_RS08550	COG0560	Phosphoserine phosphatase
EOK75_RS08555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
EOK75_RS08560	COG0237	dephospho-CoA kinase activity
EOK75_RS08565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EOK75_RS08570	COG0424	maF-like protein
EOK75_RS08575	COG1981	membrane
EOK75_RS08580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EOK75_RS08585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EOK75_RS08595	COG0357	Ribosomal RNA small subunit methyltransferase G
EOK75_RS08610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EOK75_RS08615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EOK75_RS08625	COG1420	regulation of RNA biosynthetic process
EOK75_RS08630	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EOK75_RS08635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EOK75_RS08645	COG0281	malic enzyme
EOK75_RS08645	COG0280	phosphate acetyltransferase
EOK75_RS08655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EOK75_RS08660	COG0137	argininosuccinate synthase activity
EOK75_RS08665	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EOK75_RS08675	COG0745	RESPONSE REGULATOR receiver
EOK75_RS08715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EOK75_RS08720	COG0300	oxidoreductase activity
EOK75_RS08765	COG0494	nUDIX hydrolase
EOK75_RS08775	COG1132	(ABC) transporter
EOK75_RS08780	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EOK75_RS08790	COG3034	peptidoglycan biosynthetic process
EOK75_RS08805	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EOK75_RS08810	COG3181	Tripartite tricarboxylate transporter family receptor
EOK75_RS08850	COG1349	DNA-binding transcription factor activity
EOK75_RS08860	COG3842	ATPase activity
EOK75_RS08870	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS08920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EOK75_RS08940	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EOK75_RS08945	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
EOK75_RS08955	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
EOK75_RS08960	COG1999	signal sequence binding
EOK75_RS08975	COG0802	atpase or kinase
EOK75_RS08980	COG3178	'Phosphotransferase
EOK75_RS08985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EOK75_RS08995	COG1074	ATP-dependent DNA helicase activity
EOK75_RS09030	COG0625	glutathione transferase activity
EOK75_RS09045	COG0436	Aminotransferase
EOK75_RS09050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EOK75_RS09060	COG1802	Transcriptional regulator
EOK75_RS09070	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS09085	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EOK75_RS09085	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS09090	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EOK75_RS09125	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EOK75_RS09130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EOK75_RS09135	COG1609	Transcriptional regulator
EOK75_RS09140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EOK75_RS09145	COG4134	Bacterial extracellular solute-binding protein
EOK75_RS09150	COG4135	transport system, permease component
EOK75_RS09155	COG4136	ATPase activity
EOK75_RS09165	COG3191	aminopeptidase activity
EOK75_RS09170	COG0314	molybdopterin synthase activity
EOK75_RS09180	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EOK75_RS09200	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
EOK75_RS09210	COG1091	dTDP-4-dehydrorhamnose reductase activity
EOK75_RS09215	COG0431	NADPH-dependent FMN reductase
EOK75_RS09225	COG0798	PFAM Bile acid sodium symporter
EOK75_RS09240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EOK75_RS09250	COG0557	exoribonuclease II activity
EOK75_RS09255	COG2951	lytic endotransglycosylase activity
EOK75_RS09260	COG1706	bacterial-type flagellum-dependent cell motility
EOK75_RS09280	COG1360	Flagellar Motor Protein
EOK75_RS09285	COG0384	phenazine biosynthesis protein PhzF
EOK75_RS09295	COG1902	pentaerythritol trinitrate reductase activity
EOK75_RS09335	COG1802	Transcriptional regulator
EOK75_RS09340	COG0813	purine-nucleoside phosphorylase activity
EOK75_RS09385	COG2030	dehydratase
EOK75_RS09400	COG2301	Belongs to the HpcH HpaI aldolase family
EOK75_RS09410	COG0039	L-malate dehydrogenase activity
EOK75_RS09425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EOK75_RS09430	COG0567	Dehydrogenase, E1 component
EOK75_RS09435	COG0508	dehydrogenase complex catalyzes the overall conversion of
EOK75_RS09455	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EOK75_RS09455	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EOK75_RS09460	COG0604	alcohol dehydrogenase
EOK75_RS09470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EOK75_RS09480	COG0167	dihydroorotate dehydrogenase activity
EOK75_RS09490	COG0737	Belongs to the 5'-nucleotidase family
EOK75_RS09500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EOK75_RS09510	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EOK75_RS09525	COG0673	inositol 2-dehydrogenase activity
EOK75_RS09540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EOK75_RS09545	COG3962	Belongs to the TPP enzyme family
EOK75_RS09550	COG0673	inositol 2-dehydrogenase activity
EOK75_RS09560	COG0673	inositol 2-dehydrogenase activity
EOK75_RS09565	COG1609	Transcriptional regulator
EOK75_RS09585	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EOK75_RS09595	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EOK75_RS09600	COG0066	3-isopropylmalate dehydratase activity
EOK75_RS09610	COG0473	3-isopropylmalate dehydrogenase activity
EOK75_RS09615	COG0825	malonyl-CoA metabolic process
EOK75_RS09625	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EOK75_RS09635	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EOK75_RS09635	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS09660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS09665	COG0601	transmembrane transport
EOK75_RS09670	COG4166	transmembrane transport
EOK75_RS09675	COG0471	metal ion transport
EOK75_RS09675	COG3273	potassium ion transport
EOK75_RS09680	COG2188	Transcriptional regulator
EOK75_RS09715	COG3264	Mechanosensitive ion channel
EOK75_RS09715	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EOK75_RS09720	COG0799	negative regulation of ribosome biogenesis
EOK75_RS09725	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EOK75_RS09730	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EOK75_RS09740	COG0793	Belongs to the peptidase S41A family
EOK75_RS09775	COG2010	Cytochrome c
EOK75_RS09780	COG1573	uracil-dna glycosylase
EOK75_RS09785	COG0348	domain, Protein
EOK75_RS09805	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS09810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EOK75_RS09815	COG1320	monovalent cation:proton antiporter activity
EOK75_RS09820	COG2212	antiporter activity
EOK75_RS09830	COG0651	ATP synthesis coupled electron transport
EOK75_RS09835	COG1006	Multisubunit Na H antiporter MnhC subunit
EOK75_RS09840	COG2111	Na H antiporter
EOK75_RS09840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EOK75_RS09845	COG0285	dihydrofolate synthase activity
EOK75_RS09850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EOK75_RS09860	COG3909	cytochrome
EOK75_RS09865	COG1054	Belongs to the UPF0176 family
EOK75_RS09870	COG1335	isochorismatase
EOK75_RS09880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EOK75_RS09885	COG0306	phosphate transporter
EOK75_RS09900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EOK75_RS09930	COG4974	Belongs to the 'phage' integrase family
EOK75_RS09955	COG1702	phosphate starvation-inducible protein PhoH
EOK75_RS09960	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EOK75_RS09965	COG1253	flavin adenine dinucleotide binding
EOK75_RS09970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EOK75_RS09985	COG0646	methionine synthase
EOK75_RS09985	COG1410	methionine synthase
EOK75_RS10010	COG0352	thiamine-phosphate diphosphorylase activity
EOK75_RS10015	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
EOK75_RS10030	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EOK75_RS10035	COG1024	Enoyl-CoA hydratase
EOK75_RS10055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EOK75_RS10090	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EOK75_RS10160	COG0523	cobalamin synthesis protein
EOK75_RS10175	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
EOK75_RS10195	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EOK75_RS10205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EOK75_RS10210	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS10320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EOK75_RS10360	COG1218	3'(2'),5'-bisphosphate nucleotidase
EOK75_RS10380	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EOK75_RS10385	COG0612	Peptidase, M16
EOK75_RS10390	COG0612	Peptidase, M16
EOK75_RS10400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EOK75_RS10405	COG0138	bifunctional purine biosynthesis protein purh
EOK75_RS10415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EOK75_RS10415	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EOK75_RS10425	COG3806	Anti-sigma factor
EOK75_RS10430	COG1595	DNA-templated transcription, initiation
EOK75_RS10435	COG0300	oxidoreductase activity
EOK75_RS10465	COG0438	transferase activity, transferring glycosyl groups
EOK75_RS10525	COG0745	RESPONSE REGULATOR receiver
EOK75_RS10545	COG0559	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS10575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EOK75_RS10575	COG0616	signal peptide processing
EOK75_RS10595	COG0322	excinuclease ABC activity
EOK75_RS10605	COG0657	acetylesterase activity
EOK75_RS10620	COG3214	Protein conserved in bacteria
EOK75_RS10625	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EOK75_RS10660	COG4175	Glycine betaine
EOK75_RS10660	COG0517	IMP dehydrogenase activity
EOK75_RS10665	COG4176	ABC-type proline glycine betaine transport system permease component
EOK75_RS10680	COG4191	Histidine kinase
EOK75_RS10685	COG2223	nitrite transmembrane transporter activity
EOK75_RS10700	COG0583	DNA-binding transcription factor activity
EOK75_RS10705	COG0779	Required for maturation of 30S ribosomal subunits
EOK75_RS10720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EOK75_RS10725	COG0494	nUDIX hydrolase
EOK75_RS10730	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EOK75_RS10735	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EOK75_RS10740	COG0653	protein targeting
EOK75_RS10750	COG2003	Belongs to the UPF0758 family
EOK75_RS10755	COG0484	heat shock protein binding
EOK75_RS10760	COG0443	Heat shock 70 kDa protein
EOK75_RS10770	COG0284	orotidine-5'-phosphate decarboxylase activity
EOK75_RS10780	COG0542	response to heat
EOK75_RS10795	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EOK75_RS10800	COG3239	Fatty acid desaturase
EOK75_RS10810	COG0625	glutathione transferase activity
EOK75_RS10830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
EOK75_RS10835	COG4143	(ABC) transporter
EOK75_RS10845	COG1178	ABC-type Fe3 transport system permease component
EOK75_RS10850	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
EOK75_RS10860	COG2271	Major facilitator Superfamily
EOK75_RS10865	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EOK75_RS10875	COG0288	reversible hydration of carbon dioxide
EOK75_RS10885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EOK75_RS10890	COG0791	NLP P60 protein
EOK75_RS10895	COG1376	ErfK ybiS ycfS ynhG family protein
EOK75_RS10970	COG2171	N-acyltransferase activity
EOK75_RS10995	COG0129	dihydroxy-acid dehydratase activity
EOK75_RS11015	COG0446	pyridine nucleotide-disulphide oxidoreductase
EOK75_RS11015	COG1902	pentaerythritol trinitrate reductase activity
EOK75_RS11025	COG0583	DNA-binding transcription factor activity
EOK75_RS11040	COG1546	Belongs to the CinA family
EOK75_RS11040	COG1058	Belongs to the CinA family
EOK75_RS11045	COG0024	Methionine aminopeptidase
EOK75_RS11050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EOK75_RS11055	COG0742	ribosomal rna small subunit methyltransferase
EOK75_RS11065	COG0678	peroxiredoxin activity
EOK75_RS11070	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
EOK75_RS11075	COG2154	pterin-4-alpha-carbinolamine dehydratase
EOK75_RS11090	COG0584	glycerophosphoryl diester phosphodiesterase
EOK75_RS11110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EOK75_RS11115	COG0004	ammonium transporteR
EOK75_RS11120	COG0737	Belongs to the 5'-nucleotidase family
EOK75_RS11145	COG4166	transmembrane transport
EOK75_RS11150	COG4174	ABC transporter (Permease)
EOK75_RS11155	COG4239	(ABC) transporter, permease
EOK75_RS11160	COG4172	Belongs to the ABC transporter superfamily
EOK75_RS11165	COG0438	transferase activity, transferring glycosyl groups
EOK75_RS11170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EOK75_RS11175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EOK75_RS11180	COG0384	phenazine biosynthesis protein PhzF
EOK75_RS11185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EOK75_RS11200	COG2884	Cell division ATP-binding protein ftsE
EOK75_RS11215	COG0019	diaminopimelate decarboxylase activity
EOK75_RS11225	COG0165	Argininosuccinate lyase
EOK75_RS11230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EOK75_RS11235	COG2818	Glycosylase
EOK75_RS11240	COG2200	EAL domain
EOK75_RS11270	COG0142	geranyltranstransferase activity
EOK75_RS11275	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EOK75_RS11325	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS11330	COG0009	L-threonylcarbamoyladenylate synthase
EOK75_RS11335	COG1970	mechanosensitive ion channel activity
EOK75_RS11340	COG0686	Belongs to the AlaDH PNT family
EOK75_RS11345	COG1183	phosphatidylcholine synthase activity
EOK75_RS11365	COG3321	synthase
EOK75_RS11365	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS11365	COG0604	alcohol dehydrogenase
EOK75_RS11385	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EOK75_RS11390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EOK75_RS11405	COG1162	GTPase activity
EOK75_RS11480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EOK75_RS11505	COG2897	thiosulfate sulfurtransferase activity
EOK75_RS11530	COG1845	cytochrome c oxidase, subunit III
EOK75_RS11540	COG0714	Associated with various cellular activities
EOK75_RS11565	COG0348	domain, Protein
EOK75_RS11565	COG3901	Regulator of nitric oxide reductase transcription
EOK75_RS11570	COG2010	Cytochrome c
EOK75_RS11575	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EOK75_RS11580	COG2010	Cytochrome c
EOK75_RS11585	COG3391	amine dehydrogenase activity
EOK75_RS11590	COG1522	sequence-specific DNA binding
EOK75_RS11605	COG0535	radical SAM domain protein
EOK75_RS11655	COG0521	Mo-molybdopterin cofactor biosynthetic process
EOK75_RS11660	COG1573	uracil-dna glycosylase
EOK75_RS11680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EOK75_RS11700	COG1872	DUF167
EOK75_RS11710	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS11720	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EOK75_RS11730	COG1686	Belongs to the peptidase S11 family
EOK75_RS11760	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EOK75_RS11805	COG0667	Aldo Keto reductase
EOK75_RS11865	COG0546	phosphoglycolate phosphatase activity
EOK75_RS11875	COG2130	NADP-dependent
EOK75_RS11885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EOK75_RS11890	COG0287	Prephenate dehydrogenase
EOK75_RS11905	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
EOK75_RS11925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EOK75_RS11950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EOK75_RS11955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EOK75_RS11985	COG2983	Belongs to the UPF0260 family
EOK75_RS11990	COG0196	riboflavin kinase activity
EOK75_RS11995	COG2030	dehydratase
EOK75_RS12005	COG1227	inorganic diphosphatase activity
EOK75_RS12020	COG0459	protein refolding
EOK75_RS12030	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EOK75_RS12055	COG0492	ferredoxin-NADP+ reductase activity
EOK75_RS12060	COG1522	sequence-specific DNA binding
EOK75_RS12065	COG1496	oxidoreductase activity
EOK75_RS12075	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EOK75_RS12085	COG0179	Fumarylacetoacetate (FAA) hydrolase
EOK75_RS12095	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EOK75_RS12105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EOK75_RS12125	COG0606	chelatase, subunit chli
EOK75_RS12175	COG0747	negative chemotaxis
EOK75_RS12185	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS12195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS12230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS12235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EOK75_RS12245	COG2186	Transcriptional regulator
EOK75_RS12250	COG0028	Belongs to the TPP enzyme family
EOK75_RS12275	COG2186	Transcriptional regulator
EOK75_RS12280	COG4221	oxidoreductase activity
EOK75_RS12285	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS12300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EOK75_RS12305	COG2084	Dehydrogenase
EOK75_RS12325	COG0436	Aminotransferase
EOK75_RS12330	COG1024	Enoyl-CoA hydratase
EOK75_RS12330	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS12340	COG3750	Belongs to the UPF0335 family
EOK75_RS12375	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
EOK75_RS12385	COG2027	D-alanyl-D-alanine carboxypeptidase
EOK75_RS12390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EOK75_RS12395	COG0488	(ABC) transporter
EOK75_RS12440	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
EOK75_RS12445	COG1494	fructose-1,6-bisphosphatase
EOK75_RS12460	COG1309	transcriptional regulator
EOK75_RS12470	COG1278	Cold shock
EOK75_RS12480	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EOK75_RS12495	COG3243	poly(R)-hydroxyalkanoic acid synthase
EOK75_RS12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS12515	COG0174	glutamine synthetase
EOK75_RS12535	COG0174	glutamine synthetase
EOK75_RS12550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS12565	COG0758	DNA mediated transformation
EOK75_RS12570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EOK75_RS12575	COG4175	Glycine betaine
EOK75_RS12595	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS12600	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EOK75_RS12615	COG3800	Transcriptional regulator
EOK75_RS12615	COG1396	sequence-specific DNA binding
EOK75_RS12625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EOK75_RS12640	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EOK75_RS12645	COG0509	glycine decarboxylation via glycine cleavage system
EOK75_RS12650	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EOK75_RS12650	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EOK75_RS12655	COG3118	belongs to the thioredoxin family
EOK75_RS12700	COG0438	transferase activity, transferring glycosyl groups
EOK75_RS12705	COG1132	(ABC) transporter
EOK75_RS12725	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EOK75_RS12730	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EOK75_RS12740	COG0318	PFAM AMP-dependent synthetase and ligase
EOK75_RS12750	COG3845	ABC transporter
EOK75_RS12755	COG4603	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS12760	COG1079	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS12765	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS12770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EOK75_RS12775	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EOK75_RS12780	COG3842	ATPase activity
EOK75_RS12790	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS12795	COG1177	transmembrane transport
EOK75_RS12805	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
EOK75_RS12805	COG0321	lipoyl(octanoyl) transferase activity
EOK75_RS12810	COG0084	hydrolase, TatD family'
EOK75_RS12820	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EOK75_RS12825	COG1686	Belongs to the peptidase S11 family
EOK75_RS12840	COG1840	ABC-type Fe3 transport system, periplasmic component
EOK75_RS12845	COG3956	TIGRFAM MazG family protein
EOK75_RS12850	COG1473	amidohydrolase
EOK75_RS12855	COG0010	Belongs to the arginase family
EOK75_RS12870	COG2890	protein-(glutamine-N5) methyltransferase activity
EOK75_RS12885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EOK75_RS12910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EOK75_RS12915	COG2927	DNA polymerase III (CHI subunit)
EOK75_RS12920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EOK75_RS12925	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EOK75_RS12930	COG0659	secondary active sulfate transmembrane transporter activity
EOK75_RS12935	COG0589	response to stress
EOK75_RS12960	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EOK75_RS12970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EOK75_RS12990	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EOK75_RS13005	COG0778	Nitroreductase
EOK75_RS13010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EOK75_RS13025	COG0254	rRNA binding
EOK75_RS13030	COG1192	Involved in chromosome partitioning
EOK75_RS13035	COG0640	Transcriptional regulator
EOK75_RS13050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EOK75_RS13060	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EOK75_RS13070	COG2885	chlorophyll binding
EOK75_RS13080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EOK75_RS13085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EOK75_RS13105	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EOK75_RS13115	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EOK75_RS13150	COG0800	Aldolase
EOK75_RS13155	COG0129	dihydroxy-acid dehydratase activity
EOK75_RS13160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EOK75_RS13195	COG0156	8-amino-7-oxononanoate synthase activity
EOK75_RS13205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EOK75_RS13210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EOK75_RS13210	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EOK75_RS13215	COG0436	Aminotransferase
EOK75_RS13225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
EOK75_RS13230	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EOK75_RS13245	COG0739	heme binding
EOK75_RS13250	COG2833	Protein of unknown function (DUF455)
EOK75_RS13255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EOK75_RS13270	COG0477	Major facilitator Superfamily
EOK75_RS13280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EOK75_RS13290	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EOK75_RS13310	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS13330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EOK75_RS13345	COG2354	Protein conserved in bacteria
EOK75_RS13355	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EOK75_RS13365	COG0740	serine-type endopeptidase activity
EOK75_RS13370	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EOK75_RS13385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EOK75_RS13390	COG0439	Biotin carboxylase
EOK75_RS13400	COG0493	'glutamate synthase
EOK75_RS13415	COG1309	transcriptional regulator
EOK75_RS13435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EOK75_RS13440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EOK75_RS13450	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EOK75_RS13465	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EOK75_RS13470	COG0271	Belongs to the BolA IbaG family
EOK75_RS13475	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EOK75_RS13480	COG0583	DNA-binding transcription factor activity
EOK75_RS13495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
EOK75_RS13505	COG0018	arginyl-trna synthetase
EOK75_RS13515	COG1472	Belongs to the glycosyl hydrolase 3 family
EOK75_RS13520	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EOK75_RS13525	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EOK75_RS13530	COG0717	Belongs to the dCTP deaminase family
EOK75_RS13550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EOK75_RS13555	COG0416	fatty acid biosynthetic process
EOK75_RS13560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EOK75_RS13580	COG1959	2 iron, 2 sulfur cluster binding
EOK75_RS13585	COG0033	Phosphoglucomutase
EOK75_RS13590	COG0837	glucose binding
EOK75_RS13595	COG1653	transport
EOK75_RS13600	COG1175	transmembrane transport
EOK75_RS13605	COG0395	ABC-type sugar transport system, permease component
EOK75_RS13610	COG3842	ATPase activity
EOK75_RS13625	COG0516	GMP reductase activity
EOK75_RS13625	COG0517	IMP dehydrogenase activity
EOK75_RS13630	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
EOK75_RS13630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EOK75_RS13650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EOK75_RS13660	COG0121	glutamine amidotransferase
EOK75_RS13705	COG2239	Acts as a magnesium transporter
EOK75_RS13710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EOK75_RS13715	COG5012	cobalamin binding
EOK75_RS13725	COG1410	methionine synthase
EOK75_RS13725	COG0646	methionine synthase
EOK75_RS13735	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EOK75_RS13745	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS13750	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
EOK75_RS13770	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EOK75_RS13775	COG0305	Participates in initiation and elongation during chromosome replication
EOK75_RS13785	COG0418	dihydroorotase activity
EOK75_RS13810	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS13815	COG0583	DNA-binding transcription factor activity
EOK75_RS13825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EOK75_RS13840	COG1522	sequence-specific DNA binding
EOK75_RS13845	COG0149	triose-phosphate isomerase activity
EOK75_RS13850	COG0316	Belongs to the HesB IscA family
EOK75_RS13855	COG2151	metal-sulfur cluster biosynthetic enzyme
EOK75_RS13865	COG0028	Belongs to the TPP enzyme family
EOK75_RS13875	COG1024	Enoyl-CoA hydratase
EOK75_RS13880	COG3088	subunit of a heme lyase
EOK75_RS13885	COG1138	Cytochrome C-type biogenesis protein
EOK75_RS13895	COG0010	Belongs to the arginase family
EOK75_RS13905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EOK75_RS13920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EOK75_RS13935	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EOK75_RS13940	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EOK75_RS13960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EOK75_RS13965	COG3494	Protein of unknown function (DUF1009)
EOK75_RS13970	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EOK75_RS13985	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EOK75_RS13990	COG0750	zinc metalloprotease
EOK75_RS13995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EOK75_RS14005	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EOK75_RS14010	COG0233	cytoplasmic translational termination
EOK75_RS14015	COG4191	Histidine kinase
EOK75_RS14015	COG0784	Response regulator, receiver
EOK75_RS14035	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EOK75_RS14050	COG0719	Fe-S assembly protein
EOK75_RS14055	COG0396	ATPase activity
EOK75_RS14060	COG0719	Fe-S assembly protein
EOK75_RS14070	COG1959	2 iron, 2 sulfur cluster binding
EOK75_RS14075	COG2945	thiolester hydrolase activity
EOK75_RS14090	COG0538	isocitrate dehydrogenase activity
EOK75_RS14100	COG1217	gtp-binding protein TYPA
EOK75_RS14160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EOK75_RS14170	COG1376	ErfK ybiS ycfS ynhG family protein
EOK75_RS14170	COG1388	LysM domain
EOK75_RS14180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EOK75_RS14185	COG0308	aminopeptidase N
EOK75_RS14195	COG0415	Belongs to the DNA photolyase family
EOK75_RS14200	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EOK75_RS14300	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EOK75_RS14305	COG0741	lytic transglycosylase activity
EOK75_RS14310	COG0629	single-stranded DNA binding
EOK75_RS14330	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS14335	COG1917	Cupin 2, conserved barrel domain protein
EOK75_RS14340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EOK75_RS14365	COG0321	lipoyl(octanoyl) transferase activity
EOK75_RS14370	COG3474	cytochrome
EOK75_RS14385	COG1610	YqeY-like protein
EOK75_RS14390	COG0505	Belongs to the CarA family
EOK75_RS14400	COG1802	Transcriptional regulator
EOK75_RS14410	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EOK75_RS14420	COG1522	sequence-specific DNA binding
EOK75_RS14425	COG1522	sequence-specific DNA binding
EOK75_RS14430	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EOK75_RS14440	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EOK75_RS14445	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EOK75_RS14450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
EOK75_RS14455	COG3409	Peptidoglycan-binding domain 1 protein
EOK75_RS14455	COG3773	Cell wall hydrolase
EOK75_RS14460	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EOK75_RS14460	COG0574	Belongs to the PEP-utilizing enzyme family
EOK75_RS14465	COG0697	spore germination
EOK75_RS14470	COG2423	ornithine cyclodeaminase activity
EOK75_RS14485	COG1671	Belongs to the UPF0178 family
EOK75_RS14490	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EOK75_RS14495	COG0679	Auxin Efflux Carrier
EOK75_RS14505	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
EOK75_RS14525	COG0483	inositol monophosphate 1-phosphatase activity
EOK75_RS14530	COG1396	sequence-specific DNA binding
EOK75_RS14535	COG0604	alcohol dehydrogenase
EOK75_RS14535	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS14535	COG3321	synthase
EOK75_RS14545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS14550	COG0601	transmembrane transport
EOK75_RS14560	COG2936	dipeptidyl-peptidase activity
EOK75_RS14565	COG3119	arylsulfatase activity
EOK75_RS14575	COG1024	Enoyl-CoA hydratase
EOK75_RS14585	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS14590	COG0824	Thioesterase
EOK75_RS14590	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS14595	COG3246	L-lysine catabolic process to acetate
EOK75_RS14605	COG0339	signal peptide processing
EOK75_RS14620	COG2183	response to ionizing radiation
EOK75_RS14630	COG3842	ATPase activity
EOK75_RS14635	COG0165	Argininosuccinate lyase
EOK75_RS14640	COG0395	ABC-type sugar transport system, permease component
EOK75_RS14655	COG1940	carbohydrate kinase activity
EOK75_RS14675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EOK75_RS14675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EOK75_RS14680	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EOK75_RS14685	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EOK75_RS14695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EOK75_RS14700	COG0358	DNA primase activity
EOK75_RS14705	COG1473	amidohydrolase
EOK75_RS14715	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EOK75_RS14715	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS14725	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EOK75_RS14730	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EOK75_RS14735	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS14745	COG2986	histidine ammonia-lyase
EOK75_RS14750	COG1228	amidohydrolase
EOK75_RS14755	COG0402	S-adenosylhomocysteine deaminase activity
EOK75_RS14765	COG0670	Belongs to the BI1 family
EOK75_RS14830	COG3023	N-Acetylmuramoyl-L-alanine amidase
EOK75_RS14840	COG0154	amidase activity
EOK75_RS14850	COG2124	cytochrome p450
EOK75_RS14860	COG0785	Cytochrome C biogenesis protein
EOK75_RS14865	COG1530	ribonuclease E activity
EOK75_RS14885	COG2321	neutral zinc metallopeptidase
EOK75_RS14890	COG1238	metal cluster binding
EOK75_RS14900	COG3263	regulation of cellular component size
EOK75_RS14905	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EOK75_RS14910	COG0316	Belongs to the HesB IscA family
EOK75_RS14920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EOK75_RS14945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EOK75_RS14950	COG1984	allophanate hydrolase subunit 2
EOK75_RS14965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EOK75_RS14970	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EOK75_RS14985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EOK75_RS14990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EOK75_RS14995	COG0751	glycine-tRNA ligase activity
EOK75_RS15005	COG0752	glycyl-tRNA synthetase alpha subunit
EOK75_RS15015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
EOK75_RS15030	COG3264	Mechanosensitive ion channel
EOK75_RS15030	COG1511	domain protein
EOK75_RS15035	COG2917	probably involved in intracellular septation
EOK75_RS15040	COG0154	amidase activity
EOK75_RS15055	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EOK75_RS15060	COG1349	DNA-binding transcription factor activity
EOK75_RS15075	COG3639	organic phosphonate transmembrane transporter activity
EOK75_RS15085	COG1011	Hydrolase
EOK75_RS15115	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EOK75_RS15125	COG2124	cytochrome p450
EOK75_RS15130	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EOK75_RS15140	COG0300	oxidoreductase activity
EOK75_RS15150	COG2096	Adenosyltransferase
EOK75_RS15170	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS15175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EOK75_RS15190	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EOK75_RS15195	COG0642	Histidine kinase
EOK75_RS15200	COG0745	RESPONSE REGULATOR receiver
EOK75_RS15205	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
EOK75_RS15225	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EOK75_RS15230	COG0571	ribonuclease III activity
EOK75_RS15235	COG0681	Belongs to the peptidase S26 family
EOK75_RS15265	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EOK75_RS15275	COG1238	metal cluster binding
EOK75_RS15280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EOK75_RS15290	COG2860	membrane
EOK75_RS15300	COG0248	Ppx GppA phosphatase
EOK75_RS15310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
EOK75_RS15315	COG0646	methionine synthase
EOK75_RS15315	COG1410	methionine synthase
EOK75_RS15335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EOK75_RS15345	COG2326	polyphosphate kinase activity
EOK75_RS15355	COG3842	ATPase activity
EOK75_RS15365	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS15375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EOK75_RS15385	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EOK75_RS15390	COG2233	PERMEase
EOK75_RS15395	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
EOK75_RS15400	COG3257	ureidoglycine aminohydrolase activity
EOK75_RS15410	COG2351	hydroxyisourate hydrolase activity
EOK75_RS15415	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EOK75_RS15420	COG1214	PFAM Peptidase M22, glycoprotease
EOK75_RS15425	COG0456	acetyltransferase
EOK75_RS15430	COG1744	ABC transporter substrate-binding protein PnrA-like
EOK75_RS15435	COG3845	ABC transporter
EOK75_RS15445	COG1079	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS15450	COG0730	response to heat
EOK75_RS15460	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EOK75_RS15465	COG0534	Mate efflux family protein
EOK75_RS15490	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS15500	COG0625	glutathione transferase activity
EOK75_RS15505	COG0183	Belongs to the thiolase family
EOK75_RS15510	COG1250	3-hydroxyacyl-CoA dehydrogenase
EOK75_RS15510	COG1024	Enoyl-CoA hydratase
EOK75_RS15520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EOK75_RS15525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EOK75_RS15560	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EOK75_RS15570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EOK75_RS15575	COG1832	CoA-binding protein
EOK75_RS15580	COG0140	phosphoribosyl-ATP diphosphatase activity
EOK75_RS15585	COG0107	imidazoleglycerol-phosphate synthase activity
EOK75_RS15590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EOK75_RS15600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EOK75_RS15615	COG2873	o-acetylhomoserine
EOK75_RS15660	COG3237	CsbD-like
EOK75_RS15685	COG0784	Response regulator, receiver
EOK75_RS15695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EOK75_RS15700	COG1070	Carbohydrate kinase
EOK75_RS15710	COG2995	paraquat-inducible protein a
EOK75_RS15715	COG3008	intermembrane lipid transfer
EOK75_RS15715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EOK75_RS15745	COG1175	transmembrane transport
EOK75_RS15760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EOK75_RS15765	COG1177	transmembrane transport
EOK75_RS15775	COG3842	ATPase activity
EOK75_RS15785	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EOK75_RS15805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS15810	COG3842	ATPase activity
EOK75_RS15815	COG1177	transmembrane transport
EOK75_RS15820	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS15840	COG0745	RESPONSE REGULATOR receiver
EOK75_RS15845	COG0346	lactoylglutathione lyase activity
EOK75_RS15860	COG0778	Nitroreductase
EOK75_RS15865	COG3153	acetyltransferase
EOK75_RS15865	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EOK75_RS15880	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EOK75_RS15890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EOK75_RS15915	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EOK75_RS15935	COG0028	Belongs to the TPP enzyme family
EOK75_RS15955	COG1414	Transcriptional regulator
EOK75_RS15970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EOK75_RS15975	COG0235	Class ii aldolase
EOK75_RS15980	COG0028	Belongs to the TPP enzyme family
EOK75_RS16005	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS16010	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS16015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS16020	COG0601	transmembrane transport
EOK75_RS16025	COG0747	negative chemotaxis
EOK75_RS16070	COG1247	-acetyltransferase
EOK75_RS16075	COG0789	Transcriptional regulator
EOK75_RS16115	COG0640	Transcriptional regulator
EOK75_RS16130	COG0625	glutathione transferase activity
EOK75_RS16135	COG0747	negative chemotaxis
EOK75_RS16140	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS16145	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS16150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS16155	COG0601	transmembrane transport
EOK75_RS16165	COG1309	transcriptional regulator
EOK75_RS16170	COG1979	alcohol dehydrogenase
EOK75_RS16175	COG2130	NADP-dependent
EOK75_RS16240	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS16245	COG3842	ATPase activity
EOK75_RS16255	COG4177	L-phenylalanine transmembrane transporter activity
EOK75_RS16275	COG0583	DNA-binding transcription factor activity
EOK75_RS16295	COG1063	alcohol dehydrogenase
EOK75_RS16305	COG0583	DNA-binding transcription factor activity
EOK75_RS16310	COG2175	clavaminate synthase activity
EOK75_RS16360	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EOK75_RS16370	COG3300	MHYT domain
EOK75_RS16370	COG5001	Diguanylate cyclase
EOK75_RS16450	COG4964	Belongs to the GSP D family
EOK75_RS16505	COG0420	3'-5' exonuclease activity
EOK75_RS16510	COG0419	ATPase involved in DNA repair
EOK75_RS16515	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EOK75_RS16530	COG3181	Tripartite tricarboxylate transporter family receptor
EOK75_RS16550	COG1454	alcohol dehydrogenase
EOK75_RS16555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EOK75_RS16570	COG0395	ABC-type sugar transport system, permease component
EOK75_RS16580	COG3842	ATPase activity
EOK75_RS16585	COG3842	ATPase activity
EOK75_RS16615	COG2205	protein histidine kinase activity
EOK75_RS16615	COG2202	Pas domain
EOK75_RS16620	COG0156	8-amino-7-oxononanoate synthase activity
EOK75_RS16670	COG2205	protein histidine kinase activity
EOK75_RS16670	COG2198	Histidine kinase
EOK75_RS16670	COG0784	Response regulator, receiver
EOK75_RS16680	COG3547	Transposase (IS116 IS110 IS902 family)
EOK75_RS16740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EOK75_RS16745	COG3737	Protein of unknown function (DUF498/DUF598)
EOK75_RS16750	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EOK75_RS16755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EOK75_RS16760	COG1862	Preprotein translocase
EOK75_RS16790	COG1177	transmembrane transport
EOK75_RS16795	COG1176	ABC-type spermidine putrescine transport system, permease component I
EOK75_RS16800	COG2986	histidine ammonia-lyase
EOK75_RS16815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EOK75_RS16835	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EOK75_RS16850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
EOK75_RS16875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
EOK75_RS16885	COG0424	maF-like protein
EOK75_RS16895	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EOK75_RS16900	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EOK75_RS16910	COG1278	Cold shock
EOK75_RS16920	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EOK75_RS16925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EOK75_RS16950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EOK75_RS16955	COG0590	tRNA wobble adenosine to inosine editing
EOK75_RS16960	COG1187	pseudouridine synthase activity
EOK75_RS16975	COG3853	Toxic anion resistance protein (TelA)
EOK75_RS16995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EOK75_RS17005	COG1490	D-aminoacyl-tRNA deacylase activity
EOK75_RS17010	COG0318	PFAM AMP-dependent synthetase and ligase
EOK75_RS17015	COG1132	(ABC) transporter
EOK75_RS17020	COG2267	carboxylic ester hydrolase activity
EOK75_RS17045	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EOK75_RS17050	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EOK75_RS17075	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EOK75_RS17085	COG3845	ABC transporter
EOK75_RS17090	COG4603	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS17095	COG1079	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS17105	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
EOK75_RS17305	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EOK75_RS17315	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EOK75_RS17320	COG0709	Synthesizes selenophosphate from selenide and ATP
EOK75_RS17325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EOK75_RS17345	COG1283	sodium-dependent phosphate transmembrane transporter activity
EOK75_RS17350	COG0583	DNA-binding transcription factor activity
EOK75_RS17365	COG3383	formate dehydrogenase (NAD+) activity
EOK75_RS17370	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EOK75_RS17380	COG2186	Transcriptional regulator
EOK75_RS17385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EOK75_RS17390	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
EOK75_RS17400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EOK75_RS17405	COG0765	amino acid transport
EOK75_RS17420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS17425	COG3938	Belongs to the proline racemase family
EOK75_RS17435	COG3938	Belongs to the proline racemase family
EOK75_RS17440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EOK75_RS17450	COG2832	Protein of unknown function (DUF454)
EOK75_RS17455	COG0446	pyridine nucleotide-disulphide oxidoreductase
EOK75_RS17465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EOK75_RS17470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EOK75_RS17475	COG1121	(ABC) transporter
EOK75_RS17480	COG0803	Belongs to the bacterial solute-binding protein 9 family
EOK75_RS17485	COG3022	response to hydroperoxide
EOK75_RS17490	COG0514	ATP-dependent DNA helicase (RecQ)
EOK75_RS17505	COG2270	Major facilitator Superfamily
EOK75_RS17510	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
EOK75_RS17520	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
EOK75_RS17545	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
EOK75_RS17560	COG4181	ATPase activity
EOK75_RS17570	COG0277	FAD linked oxidase domain protein
EOK75_RS17580	COG0181	hydroxymethylbilane synthase activity
EOK75_RS17585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EOK75_RS17595	COG0754	glutathionylspermidine amidase activity
EOK75_RS17600	COG5463	Belongs to the UPF0441 family
EOK75_RS17610	COG1304	FMN binding
EOK75_RS17615	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EOK75_RS17635	COG0133	tryptophan synthase activity
EOK75_RS17645	COG0135	phosphoribosylanthranilate isomerase activity
EOK75_RS17655	COG0776	regulation of translation
EOK75_RS17660	COG0539	negative regulation of cytoplasmic translation
EOK75_RS17665	COG0778	Nitroreductase
EOK75_RS17675	COG0626	cystathionine gamma-synthase activity
EOK75_RS17685	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
EOK75_RS17690	COG0242	peptide deformylase activity
EOK75_RS17695	COG0242	peptide deformylase activity
EOK75_RS17700	COG0242	peptide deformylase activity
EOK75_RS17705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EOK75_RS17720	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EOK75_RS17740	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
EOK75_RS17745	COG5002	protein histidine kinase activity
EOK75_RS17745	COG0784	Response regulator, receiver
EOK75_RS17745	COG2205	protein histidine kinase activity
EOK75_RS17760	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EOK75_RS17760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EOK75_RS17770	COG0028	Belongs to the TPP enzyme family
EOK75_RS17775	COG0741	lytic transglycosylase activity
EOK75_RS17780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EOK75_RS17800	COG0069	glutamate synthase activity
EOK75_RS17805	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EOK75_RS17870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EOK75_RS17885	COG0175	sulfate reduction
EOK75_RS17895	COG4988	ABC transporter
EOK75_RS17900	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EOK75_RS17910	COG1294	oxidase, subunit
EOK75_RS17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EOK75_RS17945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EOK75_RS17965	COG0356	it plays a direct role in the translocation of protons across the membrane
EOK75_RS17975	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EOK75_RS17980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EOK75_RS17985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EOK75_RS18000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EOK75_RS18010	COG0628	permease
EOK75_RS18015	COG4176	ABC-type proline glycine betaine transport system permease component
EOK75_RS18020	COG0517	IMP dehydrogenase activity
EOK75_RS18020	COG4175	Glycine betaine
EOK75_RS18035	COG3015	lipoprotein NlpE involved in copper resistance
EOK75_RS18045	COG2358	TRAP transporter, solute receptor (TAXI family
EOK75_RS18090	COG1858	cytochrome C peroxidase
EOK75_RS18105	COG0556	nucleotide-excision repair
EOK75_RS18110	COG0552	protein localization to endoplasmic reticulum
EOK75_RS18125	COG1570	exodeoxyribonuclease VII activity
EOK75_RS18130	COG0151	Belongs to the GarS family
EOK75_RS18195	COG4974	Belongs to the 'phage' integrase family
EOK75_RS18245	COG3598	Psort location Cytoplasmic, score
EOK75_RS18245	COG0640	Transcriptional regulator
EOK75_RS18260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EOK75_RS18265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EOK75_RS18275	COG0534	Mate efflux family protein
EOK75_RS18285	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EOK75_RS18300	COG4206	TonB-dependent receptor
EOK75_RS18360	COG0457	Tetratricopeptide repeat
EOK75_RS18370	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EOK75_RS18375	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
EOK75_RS18385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EOK75_RS18390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EOK75_RS18405	COG1959	2 iron, 2 sulfur cluster binding
EOK75_RS18415	COG0415	Belongs to the DNA photolyase family
EOK75_RS18425	COG0494	nUDIX hydrolase
EOK75_RS18435	COG3264	Mechanosensitive ion channel
EOK75_RS18435	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
EOK75_RS18440	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EOK75_RS18460	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EOK75_RS18465	COG1609	Transcriptional regulator
EOK75_RS18480	COG0435	Glutathione S-transferase
EOK75_RS18515	COG1268	BioY protein
EOK75_RS18525	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
EOK75_RS18530	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
EOK75_RS18535	COG3639	organic phosphonate transmembrane transporter activity
EOK75_RS18540	COG3639	organic phosphonate transmembrane transporter activity
EOK75_RS18545	COG2186	Transcriptional regulator
EOK75_RS18550	COG3624	Phosphonate C-P lyase system protein PhnG
EOK75_RS18555	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
EOK75_RS18560	COG3626	phosphonate metabolism
EOK75_RS18565	COG3627	carbon phosphorus lyase activity
EOK75_RS18570	COG4107	phosphonate C-P lyase system protein PhnK
EOK75_RS18575	COG4778	phosphonate C-P lyase system protein PhnL
EOK75_RS18580	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EOK75_RS18580	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EOK75_RS18585	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
EOK75_RS18590	COG3454	Phosphonate metabolism
EOK75_RS18595	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EOK75_RS18605	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EOK75_RS18610	COG0804	urea catabolic process
EOK75_RS18615	COG0832	Belongs to the urease beta subunit family
EOK75_RS18625	COG0831	urea catabolic process
EOK75_RS18630	COG0829	nickel cation binding
EOK75_RS18635	COG1846	Transcriptional regulator
EOK75_RS18650	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EOK75_RS18675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EOK75_RS18680	COG2084	Dehydrogenase
EOK75_RS18685	COG1012	belongs to the aldehyde dehydrogenase family
EOK75_RS18695	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EOK75_RS18710	COG3243	poly(R)-hydroxyalkanoic acid synthase
EOK75_RS18720	COG1063	alcohol dehydrogenase
EOK75_RS18735	COG0559	Belongs to the binding-protein-dependent transport system permease family
EOK75_RS18755	COG0583	DNA-binding transcription factor activity
EOK75_RS18760	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EOK75_RS18765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EOK75_RS18770	COG1802	Transcriptional regulator
EOK75_RS18775	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
EOK75_RS18785	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS18790	COG1028	Short-chain dehydrogenase reductase Sdr
EOK75_RS18800	COG1960	acyl-CoA dehydrogenase activity
EOK75_RS18805	COG2050	protein possibly involved in aromatic compounds catabolism
EOK75_RS18815	COG0183	Belongs to the thiolase family
EOK75_RS18825	COG2030	dehydratase
EOK75_RS18830	COG1024	Enoyl-CoA hydratase
EOK75_RS18860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EOK75_RS18905	COG2301	Belongs to the HpcH HpaI aldolase family
EOK75_RS18910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EOK75_RS18955	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EOK75_RS18960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
EOK75_RS18965	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EOK75_RS18985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EOK75_RS18995	COG2855	membrane
EOK75_RS19010	COG0789	Transcriptional regulator
EOK75_RS19025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EOK75_RS19035	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EOK75_RS19040	COG3243	poly(R)-hydroxyalkanoic acid synthase
EOK75_RS19045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
EOK75_RS19050	COG1129	ABC transporter
EOK75_RS19050	COG0842	Transport permease protein
EOK75_RS19055	COG0842	Transport permease protein
EOK75_RS19065	COG1648	precorrin-2 dehydrogenase activity
EOK75_RS19065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EOK75_RS19075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EOK75_RS19080	COG0175	sulfate reduction
EOK75_RS19100	COG3754	Rhamnan synthesis protein F
EOK75_RS19135	COG2433	Pfam Transposase IS66
EOK75_RS19175	COG0583	DNA-binding transcription factor activity
EOK75_RS19195	COG1522	sequence-specific DNA binding
EOK75_RS19200	COG0483	inositol monophosphate 1-phosphatase activity
EOK75_RS19205	COG1268	BioY protein
EOK75_RS19215	COG2194	sulfuric ester hydrolase activity
EOK75_RS19220	COG0745	RESPONSE REGULATOR receiver
EOK75_RS19230	COG0640	Transcriptional regulator
EOK75_RS19245	COG1435	thymidine kinase activity
EOK75_RS19330	COG4689	acetoacetate decarboxylase
EOK75_RS19370	COG3220	belongs to the UPF0276 family
EOK75_RS19380	COG1741	Belongs to the pirin family
EOK75_RS19395	COG1741	Belongs to the pirin family
EOK75_RS19410	COG0583	DNA-binding transcription factor activity
EOK75_RS19485	COG1030	water channel activity
EOK75_RS19605	COG2971	BadF BadG BcrA BcrD
EOK75_RS19610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EOK75_RS19615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EOK75_RS19635	COG1797	cobyrinic acid a,c-diamide synthase activity
EOK75_RS19640	COG2875	Belongs to the precorrin methyltransferase family
EOK75_RS19655	COG2099	Precorrin-6x reductase
EOK75_RS19700	COG1492	cobalamin metabolic process
EOK75_RS19710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EOK75_RS19715	COG1122	ATPase activity
EOK75_RS19725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EOK75_RS19775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EOK75_RS19780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EOK75_RS19785	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EOK75_RS19795	COG0312	modulator of DNA gyrase
EOK75_RS19815	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EOK75_RS19825	COG3346	SURF1 family
EOK75_RS19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EOK75_RS19855	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
EOK75_RS19870	COG2942	2-epimerase
EOK75_RS19875	COG0246	Mannitol dehydrogenase
EOK75_RS19880	COG1312	Catalyzes the dehydration of D-mannonate
EOK75_RS19885	COG0012	GTP binding
EOK75_RS19890	COG0159	tryptophan synthase activity
EOK75_RS19895	COG0174	glutamine synthetase
EOK75_RS19905	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EOK75_RS19920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EOK75_RS19925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EOK75_RS19940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EOK75_RS19950	COG0596	Alpha beta hydrolase
EOK75_RS19955	COG2204	response regulator
EOK75_RS19960	COG2205	protein histidine kinase activity
EOK75_RS19960	COG0784	Response regulator, receiver
EOK75_RS19970	COG0280	phosphate acetyltransferase
EOK75_RS19970	COG0281	malic enzyme
EOK75_RS19975	COG0295	cytidine deaminase activity
EOK75_RS19980	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EOK75_RS19985	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
EOK75_RS19990	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EOK75_RS19995	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EOK75_RS20005	COG0481	GTPase activity
EOK75_RS20010	COG0513	Belongs to the DEAD box helicase family
EOK75_RS20025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EOK75_RS20035	COG1802	Transcriptional regulator
EOK75_RS20040	COG1053	succinate dehydrogenase
EOK75_RS20070	COG2828	Protein conserved in bacteria
EOK75_RS20075	COG0473	3-isopropylmalate dehydrogenase activity
EOK75_RS20080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EOK75_RS20090	COG0166	Belongs to the GPI family
EOK75_RS20095	COG0251	oxidation-reduction process
EOK75_RS20120	COG2391	methyltransferase activity
EOK75_RS20160	COG1192	Involved in chromosome partitioning
EOK75_RS20290	COG0297	glycogen (starch) synthase activity
EOK75_RS20315	COG3267	Type II secretory pathway component ExeA
EOK75_RS20315	COG3409	Peptidoglycan-binding domain 1 protein
EOK75_RS20325	COG0489	protein tyrosine kinase activity
EOK75_RS20370	COG1216	Glycosyl transferase, family 2
EOK75_RS20425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EOK75_RS20465	COG1216	Glycosyl transferase, family 2
EOK75_RS20500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EOK75_RS20515	COG1192	Involved in chromosome partitioning
EOK75_RS20525	COG0662	Cupin 2, conserved barrel domain protein
EOK75_RS20525	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EOK75_RS20530	COG1414	Transcriptional regulator
EOK75_RS20535	COG0747	negative chemotaxis
EOK75_RS20540	COG0601	transmembrane transport
EOK75_RS20545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EOK75_RS20550	COG0444	Belongs to the ABC transporter superfamily
EOK75_RS20555	COG4608	Belongs to the ABC transporter superfamily
EOK75_RS20560	COG0405	Gamma-glutamyltransferase
EOK75_RS20575	COG2089	acid synthase
EOK75_RS20580	COG1083	cytidylyl-transferase
EOK75_RS20590	COG1215	transferase activity, transferring glycosyl groups
EOK75_RS20635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EOK75_RS20640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EOK75_RS20655	COG2963	transposase activity
EOK75_RS20705	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EOK75_RS20705	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EOK75_RS20925	COG0776	regulation of translation
EOK75_RS21000	COG2801	Transposase and inactivated derivatives
EOK75_RS21005	COG2801	Transposase and inactivated derivatives
EOK75_RS21040	COG2871	sodium ion transport
EOK75_RS21095	COG3046	protein related to deoxyribodipyrimidine photolyase