locus-tag	class	description
CAK95_RS00070	COG3836	Belongs to the HpcH HpaI aldolase family
CAK95_RS00085	COG2080	2 iron, 2 sulfur cluster binding
CAK95_RS00095	COG0625	glutathione transferase activity
CAK95_RS00100	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS00115	COG0604	alcohol dehydrogenase
CAK95_RS00115	COG3321	synthase
CAK95_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS00125	COG1414	Transcriptional regulator
CAK95_RS00160	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS00165	COG1024	Enoyl-CoA hydratase
CAK95_RS00170	COG0346	lactoylglutathione lyase activity
CAK95_RS00175	COG0431	NADPH-dependent FMN reductase
CAK95_RS00180	COG0431	NADPH-dependent FMN reductase
CAK95_RS00185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAK95_RS00195	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS00200	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
CAK95_RS00205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAK95_RS00230	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS00235	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS00260	COG1704	LemA family
CAK95_RS00265	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS00360	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS00380	COG0411	ABC transporter
CAK95_RS00395	COG0683	leucine binding
CAK95_RS00435	COG3665	Urea carboxylase-associated protein
CAK95_RS00440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK95_RS00455	COG0604	alcohol dehydrogenase
CAK95_RS00460	COG2223	nitrite transmembrane transporter activity
CAK95_RS00470	COG0583	DNA-binding transcription factor activity
CAK95_RS00475	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CAK95_RS00490	COG2358	TRAP transporter, solute receptor (TAXI family
CAK95_RS00505	COG0574	Belongs to the PEP-utilizing enzyme family
CAK95_RS00505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CAK95_RS00515	COG0751	glycine-tRNA ligase activity
CAK95_RS00520	COG2852	Protein conserved in bacteria
CAK95_RS00525	COG0752	glycyl-tRNA synthetase alpha subunit
CAK95_RS00550	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CAK95_RS00555	COG2857	Cytochrome c1
CAK95_RS00555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAK95_RS00560	COG2857	Cytochrome c1
CAK95_RS00560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CAK95_RS00565	COG0723	plastoquinol--plastocyanin reductase activity
CAK95_RS00570	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CAK95_RS00575	COG0408	coproporphyrinogen oxidase activity
CAK95_RS00595	COG0617	tRNA 3'-terminal CCA addition
CAK95_RS00615	COG0714	Associated with various cellular activities
CAK95_RS00640	COG0435	Glutathione S-transferase
CAK95_RS00655	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAK95_RS00665	COG0154	amidase activity
CAK95_RS00670	COG5487	UPF0391 membrane protein
CAK95_RS00740	COG2183	response to ionizing radiation
CAK95_RS00750	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
CAK95_RS00755	COG2971	BadF BadG BcrA BcrD
CAK95_RS00760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAK95_RS00765	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CAK95_RS00775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS00785	COG0583	DNA-binding transcription factor activity
CAK95_RS00805	COG1304	FMN binding
CAK95_RS00810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAK95_RS00830	COG2188	Transcriptional regulator
CAK95_RS00840	COG3386	PFAM SMP-30 Gluconolaconase
CAK95_RS00865	COG1252	NADH dehydrogenase
CAK95_RS00870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAK95_RS00875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAK95_RS00880	COG1845	cytochrome c oxidase, subunit III
CAK95_RS00900	COG3387	PFAM Glycoside hydrolase 15-related
CAK95_RS00905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAK95_RS00910	COG0411	ABC transporter
CAK95_RS00925	COG1228	amidohydrolase
CAK95_RS00940	COG4638	Rieske (2fe-2S)
CAK95_RS00965	COG1737	Transcriptional regulator
CAK95_RS00970	COG0647	UMP catabolic process
CAK95_RS00975	COG3842	ATPase activity
CAK95_RS00980	COG1175	transmembrane transport
CAK95_RS00985	COG0395	ABC-type sugar transport system, permease component
CAK95_RS00990	COG1653	transport
CAK95_RS00995	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CAK95_RS01000	COG1021	2,3-dihydroxybenzoate-AMP ligase
CAK95_RS01010	COG0824	Thioesterase
CAK95_RS01030	COG1129	ABC transporter
CAK95_RS01040	COG1309	transcriptional regulator
CAK95_RS01055	COG1414	Transcriptional regulator
CAK95_RS01060	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS01080	COG2079	MmgE PrpD family protein
CAK95_RS01090	COG2423	ornithine cyclodeaminase activity
CAK95_RS01095	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS01130	COG1309	transcriptional regulator
CAK95_RS01165	COG0583	DNA-binding transcription factor activity
CAK95_RS01170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAK95_RS01175	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAK95_RS01190	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK95_RS01200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAK95_RS01210	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS01215	COG1802	Transcriptional regulator
CAK95_RS01225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK95_RS01230	COG2188	Transcriptional regulator
CAK95_RS01235	COG4597	amino acid ABC transporter
CAK95_RS01240	COG0765	amino acid transport
CAK95_RS01245	COG1126	abc transporter atp-binding protein
CAK95_RS01290	COG0463	Glycosyl transferase, family 2
CAK95_RS01325	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS01345	COG0583	DNA-binding transcription factor activity
CAK95_RS01350	COG1252	NADH dehydrogenase
CAK95_RS01360	COG3220	belongs to the UPF0276 family
CAK95_RS01385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS01450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS01465	COG1414	Transcriptional regulator
CAK95_RS01475	COG2267	carboxylic ester hydrolase activity
CAK95_RS01480	COG3971	2-oxopent-4-enoate hydratase activity
CAK95_RS01485	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS01495	COG3547	Transposase (IS116 IS110 IS902 family)
CAK95_RS01520	COG3237	CsbD-like
CAK95_RS01565	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS01610	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CAK95_RS01615	COG1278	Cold shock
CAK95_RS01620	COG0625	glutathione transferase activity
CAK95_RS01630	COG0322	excinuclease ABC activity
CAK95_RS01635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAK95_RS01645	COG0314	molybdopterin synthase activity
CAK95_RS01650	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAK95_RS01655	COG1846	Transcriptional regulator
CAK95_RS01660	COG0745	RESPONSE REGULATOR receiver
CAK95_RS01705	COG2264	protein methyltransferase activity
CAK95_RS01715	COG0006	proline dipeptidase activity
CAK95_RS01720	COG2814	Major facilitator Superfamily
CAK95_RS01725	COG0596	Alpha beta hydrolase
CAK95_RS01735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CAK95_RS01745	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAK95_RS01755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CAK95_RS01760	COG0849	cell division
CAK95_RS01765	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CAK95_RS01770	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAK95_RS01775	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS01780	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CAK95_RS01785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CAK95_RS01845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAK95_RS01850	COG2226	methyltransferase
CAK95_RS01855	COG1720	tRNA m6t6A37 methyltransferase activity
CAK95_RS01860	COG0129	dihydroxy-acid dehydratase activity
CAK95_RS01865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS01870	COG1388	LysM domain
CAK95_RS01870	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS01875	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CAK95_RS01890	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS01910	COG2022	thiamine diphosphate biosynthetic process
CAK95_RS01920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CAK95_RS01990	COG0488	(ABC) transporter
CAK95_RS02030	COG0671	phosphoesterase, PA-phosphatase related
CAK95_RS02060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS02080	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS02090	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS02110	COG0583	DNA-binding transcription factor activity
CAK95_RS02120	COG1335	isochorismatase
CAK95_RS02130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS02140	COG0583	DNA-binding transcription factor activity
CAK95_RS02160	COG0411	ABC transporter
CAK95_RS02180	COG0667	Aldo Keto reductase
CAK95_RS02195	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS02210	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS02230	COG1846	Transcriptional regulator
CAK95_RS02235	COG0028	Belongs to the TPP enzyme family
CAK95_RS02275	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS02275	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
CAK95_RS02295	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS02315	COG2948	multi-organism process
CAK95_RS02345	COG3451	type IV secretory pathway VirB4
CAK95_RS02360	COG4962	Type ii secretion system protein e
CAK95_RS02380	COG2132	Multicopper oxidase
CAK95_RS02425	COG1595	DNA-templated transcription, initiation
CAK95_RS02445	COG1595	DNA-templated transcription, initiation
CAK95_RS02530	COG1476	TRANSCRIPTIONal
CAK95_RS02535	COG5489	Protein of unknown function (DUF736)
CAK95_RS02660	COG0730	response to heat
CAK95_RS02675	COG0210	DNA helicase
CAK95_RS02680	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CAK95_RS02715	COG0590	tRNA wobble adenosine to inosine editing
CAK95_RS02725	COG0583	DNA-binding transcription factor activity
CAK95_RS02765	COG0739	heme binding
CAK95_RS02770	COG0542	response to heat
CAK95_RS02800	COG2171	N-acyltransferase activity
CAK95_RS02810	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CAK95_RS02825	COG0101	tRNA pseudouridine synthase activity
CAK95_RS02830	COG3153	acetyltransferase
CAK95_RS02840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAK95_RS02845	COG0242	peptide deformylase activity
CAK95_RS02850	COG1322	Protein conserved in bacteria
CAK95_RS02855	COG2223	nitrite transmembrane transporter activity
CAK95_RS02870	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CAK95_RS02880	COG2226	methyltransferase
CAK95_RS02885	COG1120	ATPase activity
CAK95_RS02890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAK95_RS02895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CAK95_RS02900	COG3585	molybdate ion transport
CAK95_RS02915	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAK95_RS02960	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CAK95_RS03035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAK95_RS03075	COG1475	DNA binding
CAK95_RS03080	COG1475	DNA binding
CAK95_RS03150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS03260	COG1129	ABC transporter
CAK95_RS03300	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS03335	COG2801	Transposase and inactivated derivatives
CAK95_RS03350	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS03360	COG2855	membrane
CAK95_RS03365	COG0583	DNA-binding transcription factor activity
CAK95_RS03375	COG0583	DNA-binding transcription factor activity
CAK95_RS03385	COG2814	Major facilitator Superfamily
CAK95_RS03395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CAK95_RS03435	COG1475	DNA binding
CAK95_RS03490	COG2135	peptidase activity
CAK95_RS03560	COG2132	Multicopper oxidase
CAK95_RS03590	COG4249	Peptidase C14 caspase catalytic subunit p20
CAK95_RS03595	COG4654	Cytochrome c, class I
CAK95_RS03600	COG2133	pyrroloquinoline quinone binding
CAK95_RS03655	COG1475	DNA binding
CAK95_RS03665	COG1396	sequence-specific DNA binding
CAK95_RS03670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CAK95_RS03680	COG2197	response regulator
CAK95_RS03685	COG2267	carboxylic ester hydrolase activity
CAK95_RS03715	COG2855	membrane
CAK95_RS03725	COG0492	ferredoxin-NADP+ reductase activity
CAK95_RS03730	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAK95_RS03740	COG1053	succinate dehydrogenase
CAK95_RS03755	COG2188	Transcriptional regulator
CAK95_RS03760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAK95_RS03770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS03795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS03815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAK95_RS03835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAK95_RS03845	COG1177	transmembrane transport
CAK95_RS03850	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAK95_RS03855	COG3842	ATPase activity
CAK95_RS03860	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CAK95_RS03870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAK95_RS03870	COG0519	Catalyzes the synthesis of GMP from XMP
CAK95_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS03880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAK95_RS03890	COG1309	transcriptional regulator
CAK95_RS03895	COG0028	Belongs to the TPP enzyme family
CAK95_RS03920	COG2814	Major facilitator Superfamily
CAK95_RS03950	COG0840	transmembrane signaling receptor activity
CAK95_RS03965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CAK95_RS03990	COG2885	chlorophyll binding
CAK95_RS03995	COG0823	Involved in the tonB-independent uptake of proteins
CAK95_RS04020	COG1309	transcriptional regulator
CAK95_RS04035	COG0824	Thioesterase
CAK95_RS04055	COG2255	four-way junction helicase activity
CAK95_RS04065	COG0632	four-way junction helicase activity
CAK95_RS04090	COG0217	transcriptional regulatory protein
CAK95_RS04100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK95_RS04110	COG1692	metallophosphoesterase
CAK95_RS04115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CAK95_RS04130	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
CAK95_RS04150	COG0126	phosphoglycerate kinase activity
CAK95_RS04155	COG3588	fructose-bisphosphate aldolase
CAK95_RS04185	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CAK95_RS04190	COG0483	inositol monophosphate 1-phosphatase activity
CAK95_RS04205	COG0456	acetyltransferase
CAK95_RS04210	COG1132	(ABC) transporter
CAK95_RS04215	COG0254	rRNA binding
CAK95_RS04245	COG5001	Diguanylate cyclase
CAK95_RS04250	COG1678	Uncharacterized ACR, COG1678
CAK95_RS04260	COG0678	peroxiredoxin activity
CAK95_RS04260	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CAK95_RS04265	COG0328	RNA-DNA hybrid ribonuclease activity
CAK95_RS04270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CAK95_RS04275	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAK95_RS04300	COG1234	tRNA 3'-trailer cleavage
CAK95_RS04330	COG0584	glycerophosphoryl diester phosphodiesterase
CAK95_RS04335	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS04355	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS04375	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CAK95_RS04380	COG1309	transcriptional regulator
CAK95_RS04385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAK95_RS04400	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CAK95_RS04465	COG1420	regulation of RNA biosynthetic process
CAK95_RS04470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CAK95_RS04480	COG1562	ergosterol biosynthetic process
CAK95_RS04485	COG1562	ergosterol biosynthetic process
CAK95_RS04490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAK95_RS04495	COG1657	PFAM Prenyltransferase squalene oxidase
CAK95_RS04505	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAK95_RS04510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CAK95_RS04515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CAK95_RS04535	COG1278	Cold shock
CAK95_RS04540	COG1902	pentaerythritol trinitrate reductase activity
CAK95_RS04545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS04550	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS04565	COG1846	Transcriptional regulator
CAK95_RS04585	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS04595	COG1850	ribulose-bisphosphate carboxylase activity
CAK95_RS04600	COG0662	Cupin 2, conserved barrel domain protein
CAK95_RS04610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CAK95_RS04630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CAK95_RS04660	COG2205	protein histidine kinase activity
CAK95_RS04660	COG0784	Response regulator, receiver
CAK95_RS04685	COG0140	phosphoribosyl-ATP diphosphatase activity
CAK95_RS04695	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS04705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS04710	COG0583	DNA-binding transcription factor activity
CAK95_RS04715	COG1132	(ABC) transporter
CAK95_RS04720	COG1686	Belongs to the peptidase S11 family
CAK95_RS04725	COG0523	cobalamin synthesis protein
CAK95_RS04730	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS04755	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
CAK95_RS04755	COG3264	Mechanosensitive ion channel
CAK95_RS04765	COG0840	transmembrane signaling receptor activity
CAK95_RS04775	COG1802	Transcriptional regulator
CAK95_RS04785	COG1116	anion transmembrane transporter activity
CAK95_RS04800	COG0583	DNA-binding transcription factor activity
CAK95_RS04835	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAK95_RS04865	COG1629	transport
CAK95_RS04865	COG4774	siderophore transport
CAK95_RS04885	COG1335	isochorismatase
CAK95_RS04890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS04915	COG1309	transcriptional regulator
CAK95_RS04990	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAK95_RS04995	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS05000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS05005	COG0604	alcohol dehydrogenase
CAK95_RS05030	COG2951	lytic endotransglycosylase activity
CAK95_RS05035	COG0741	lytic transglycosylase activity
CAK95_RS05145	COG0109	protoheme IX farnesyltransferase activity
CAK95_RS05160	COG1845	cytochrome c oxidase, subunit III
CAK95_RS05170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAK95_RS05175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAK95_RS05180	COG1522	sequence-specific DNA binding
CAK95_RS05185	COG1794	racemase activity, acting on amino acids and derivatives
CAK95_RS05195	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS05210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAK95_RS05230	COG1595	DNA-templated transcription, initiation
CAK95_RS05235	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAK95_RS05240	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CAK95_RS05245	COG1137	ATPase activity
CAK95_RS05260	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAK95_RS05270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK95_RS05275	COG1968	undecaprenyl-diphosphatase activity
CAK95_RS05285	COG0583	DNA-binding transcription factor activity
CAK95_RS05295	COG1234	tRNA 3'-trailer cleavage
CAK95_RS05300	COG0583	DNA-binding transcription factor activity
CAK95_RS05320	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CAK95_RS05355	COG1335	isochorismatase
CAK95_RS05370	COG0156	8-amino-7-oxononanoate synthase activity
CAK95_RS05375	COG1230	cation diffusion facilitator family transporter
CAK95_RS05390	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CAK95_RS05400	COG0583	DNA-binding transcription factor activity
CAK95_RS05430	COG0681	Belongs to the peptidase S26 family
CAK95_RS05435	COG0312	modulator of DNA gyrase
CAK95_RS05450	COG4221	oxidoreductase activity
CAK95_RS05460	COG2095	MarC family integral membrane protein
CAK95_RS05470	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAK95_RS05475	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAK95_RS05480	COG0109	protoheme IX farnesyltransferase activity
CAK95_RS05490	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CAK95_RS05505	COG3346	SURF1 family
CAK95_RS05515	COG0612	Peptidase, M16
CAK95_RS05530	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAK95_RS05535	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CAK95_RS05545	COG0356	it plays a direct role in the translocation of protons across the membrane
CAK95_RS05560	COG0432	Pfam Uncharacterised protein family UPF0047
CAK95_RS05570	COG2205	protein histidine kinase activity
CAK95_RS05575	COG1970	mechanosensitive ion channel activity
CAK95_RS05580	COG0436	Aminotransferase
CAK95_RS05585	COG1024	Enoyl-CoA hydratase
CAK95_RS05585	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS05590	COG0183	Belongs to the thiolase family
CAK95_RS05595	COG0488	(ABC) transporter
CAK95_RS05615	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS05625	COG0730	response to heat
CAK95_RS05640	COG1201	RNA secondary structure unwinding
CAK95_RS05655	COG1793	dna ligase
CAK95_RS05675	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CAK95_RS05690	COG1999	signal sequence binding
CAK95_RS05695	COG1253	flavin adenine dinucleotide binding
CAK95_RS05710	COG2755	lipolytic protein G-D-S-L family
CAK95_RS05710	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAK95_RS05715	COG2824	Alkylphosphonate utilization operon protein PhnA
CAK95_RS05745	COG0531	amino acid
CAK95_RS05755	COG0683	leucine binding
CAK95_RS05760	COG1309	transcriptional regulator
CAK95_RS05770	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CAK95_RS05775	COG1238	metal cluster binding
CAK95_RS05800	COG4829	muconolactone delta-isomerase
CAK95_RS05810	COG0717	Belongs to the dCTP deaminase family
CAK95_RS05830	COG2967	ApaG domain
CAK95_RS05850	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CAK95_RS05855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAK95_RS05865	COG0745	RESPONSE REGULATOR receiver
CAK95_RS05870	COG0704	Plays a role in the regulation of phosphate uptake
CAK95_RS05875	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CAK95_RS05880	COG0581	inorganic phosphate transmembrane transporter activity
CAK95_RS05885	COG0573	inorganic phosphate transmembrane transporter activity
CAK95_RS05890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CAK95_RS05895	COG5002	protein histidine kinase activity
CAK95_RS05930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS05940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS05955	COG1309	transcriptional regulator
CAK95_RS05960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS05965	COG1116	anion transmembrane transporter activity
CAK95_RS05975	COG1454	alcohol dehydrogenase
CAK95_RS05990	COG1309	transcriptional regulator
CAK95_RS06000	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS06010	COG0540	Belongs to the ATCase OTCase family
CAK95_RS06015	COG5001	Diguanylate cyclase
CAK95_RS06040	COG0745	RESPONSE REGULATOR receiver
CAK95_RS06045	COG0643	Histidine kinase
CAK95_RS06045	COG2198	Histidine kinase
CAK95_RS06055	COG2201	protein-glutamate methylesterase activity
CAK95_RS06060	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CAK95_RS06065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CAK95_RS06070	COG0835	chemotaxis
CAK95_RS06075	COG0583	DNA-binding transcription factor activity
CAK95_RS06080	COG0346	lactoylglutathione lyase activity
CAK95_RS06085	COG0400	carboxylic ester hydrolase activity
CAK95_RS06090	COG0402	S-adenosylhomocysteine deaminase activity
CAK95_RS06095	COG1228	amidohydrolase
CAK95_RS06100	COG2986	histidine ammonia-lyase
CAK95_RS06105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CAK95_RS06110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS06115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS06135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS06145	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAK95_RS06155	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS06160	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS06165	COG0183	Belongs to the thiolase family
CAK95_RS06170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CAK95_RS06175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
CAK95_RS06185	COG1024	Enoyl-CoA hydratase
CAK95_RS06190	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS06195	COG0183	Belongs to the thiolase family
CAK95_RS06250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CAK95_RS06265	COG1063	alcohol dehydrogenase
CAK95_RS06270	COG1116	anion transmembrane transporter activity
CAK95_RS06275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS06280	COG4521	taurine ABC transporter
CAK95_RS06285	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CAK95_RS06290	COG2207	Transcriptional regulator
CAK95_RS06305	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAK95_RS06310	COG2814	Major facilitator Superfamily
CAK95_RS06340	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAK95_RS06365	COG0730	response to heat
CAK95_RS06370	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS06400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS06440	COG0708	Exodeoxyribonuclease III
CAK95_RS06445	COG2111	Na H antiporter
CAK95_RS06445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CAK95_RS06450	COG1006	Multisubunit Na H antiporter MnhC subunit
CAK95_RS06455	COG0651	ATP synthesis coupled electron transport
CAK95_RS06465	COG2212	antiporter activity
CAK95_RS06480	COG0733	neurotransmitter:sodium symporter activity
CAK95_RS06495	COG1063	alcohol dehydrogenase
CAK95_RS06505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS06525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS06540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CAK95_RS06545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS06565	COG0303	'Molybdopterin
CAK95_RS06570	COG1763	Mo-molybdopterin cofactor biosynthetic process
CAK95_RS06580	COG0746	molybdenum cofactor guanylyltransferase activity
CAK95_RS06585	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAK95_RS06590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CAK95_RS06595	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CAK95_RS06610	COG2816	NAD+ diphosphatase activity
CAK95_RS06615	COG1522	sequence-specific DNA binding
CAK95_RS06655	COG4964	Belongs to the GSP D family
CAK95_RS06690	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAK95_RS06705	COG4172	Belongs to the ABC transporter superfamily
CAK95_RS06710	COG4239	(ABC) transporter, permease
CAK95_RS06715	COG4174	ABC transporter (Permease)
CAK95_RS06720	COG4166	transmembrane transport
CAK95_RS06725	COG4166	transmembrane transport
CAK95_RS06735	COG3474	cytochrome
CAK95_RS06740	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CAK95_RS06750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAK95_RS06755	COG3577	Aspartyl protease
CAK95_RS06760	COG2226	methyltransferase
CAK95_RS06770	COG1643	Atp-dependent helicase
CAK95_RS06775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CAK95_RS06785	COG0625	glutathione transferase activity
CAK95_RS06795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CAK95_RS06805	COG0579	oxidoreductase
CAK95_RS06825	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CAK95_RS06830	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAK95_RS06830	COG2885	chlorophyll binding
CAK95_RS06840	COG0745	RESPONSE REGULATOR receiver
CAK95_RS06845	COG0642	Histidine kinase
CAK95_RS06855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CAK95_RS06855	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAK95_RS06860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAK95_RS06870	COG1522	sequence-specific DNA binding
CAK95_RS06885	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CAK95_RS06905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAK95_RS06910	COG0785	Cytochrome C biogenesis protein
CAK95_RS06935	COG3422	double-strand break repair
CAK95_RS06950	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
CAK95_RS06955	COG1522	sequence-specific DNA binding
CAK95_RS06975	COG0725	ABC transporter, periplasmic molybdate-binding protein
CAK95_RS06980	COG4149	molybdate abc transporter
CAK95_RS06985	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CAK95_RS07000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAK95_RS07005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAK95_RS07015	COG3119	arylsulfatase activity
CAK95_RS07020	COG3263	regulation of cellular component size
CAK95_RS07025	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAK95_RS07025	COG4651	solute:proton antiporter activity
CAK95_RS07030	COG3246	L-lysine catabolic process to acetate
CAK95_RS07050	COG0129	dihydroxy-acid dehydratase activity
CAK95_RS07055	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS07070	COG0640	Transcriptional regulator
CAK95_RS07075	COG0346	lactoylglutathione lyase activity
CAK95_RS07085	COG4191	Histidine kinase
CAK95_RS07090	COG4566	intracellular signal transduction
CAK95_RS07100	COG0861	Integral membrane protein TerC family
CAK95_RS07115	COG2261	transglycosylase associated protein
CAK95_RS07150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS07170	COG1024	Enoyl-CoA hydratase
CAK95_RS07180	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS07205	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CAK95_RS07220	COG1819	glycosyl
CAK95_RS07240	COG1917	Cupin 2, conserved barrel domain protein
CAK95_RS07240	COG2169	Transcriptional regulator
CAK95_RS07255	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CAK95_RS07260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CAK95_RS07270	COG1278	Cold shock
CAK95_RS07290	COG4774	siderophore transport
CAK95_RS07300	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CAK95_RS07310	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CAK95_RS07315	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
CAK95_RS07330	COG0799	negative regulation of ribosome biogenesis
CAK95_RS07335	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CAK95_RS07345	COG0793	Belongs to the peptidase S41A family
CAK95_RS07355	COG0494	nUDIX hydrolase
CAK95_RS07360	COG2979	Protein of unknown function (DUF533)
CAK95_RS07365	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CAK95_RS07370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CAK95_RS07375	COG1764	response to oxidative stress
CAK95_RS07380	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CAK95_RS07385	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CAK95_RS07390	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CAK95_RS07395	COG2076	Multidrug Resistance protein
CAK95_RS07410	COG0659	secondary active sulfate transmembrane transporter activity
CAK95_RS07445	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CAK95_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS07465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAK95_RS07470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK95_RS07480	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAK95_RS07490	COG0045	succinate-CoA ligase (ADP-forming) activity
CAK95_RS07495	COG0039	L-malate dehydrogenase activity
CAK95_RS07500	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CAK95_RS07515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CAK95_RS07525	COG4181	ATPase activity
CAK95_RS07535	COG0670	Belongs to the BI1 family
CAK95_RS07540	COG0670	Belongs to the BI1 family
CAK95_RS07560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CAK95_RS07565	COG4133	protoheme IX ABC transporter activity
CAK95_RS07570	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAK95_RS07575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CAK95_RS07585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAK95_RS07595	COG2917	probably involved in intracellular septation
CAK95_RS07600	COG0552	protein localization to endoplasmic reticulum
CAK95_RS07605	COG0564	pseudouridine synthase activity
CAK95_RS07615	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAK95_RS07620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CAK95_RS07630	COG0583	DNA-binding transcription factor activity
CAK95_RS07650	COG0228	four-way junction DNA binding
CAK95_RS07655	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CAK95_RS07660	COG0336	Belongs to the RNA methyltransferase TrmD family
CAK95_RS07665	COG0335	large ribosomal subunit rRNA binding
CAK95_RS07680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CAK95_RS07705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAK95_RS07720	COG0066	3-isopropylmalate dehydratase activity
CAK95_RS07725	COG1280	lysine exporter protein (LysE YggA)
CAK95_RS07740	COG0288	reversible hydration of carbon dioxide
CAK95_RS07745	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CAK95_RS07785	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAK95_RS07785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAK95_RS07790	COG0473	3-isopropylmalate dehydrogenase activity
CAK95_RS07810	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAK95_RS07815	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CAK95_RS07820	COG2030	dehydratase
CAK95_RS07855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS07860	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CAK95_RS07875	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAK95_RS07900	COG1335	isochorismatase
CAK95_RS07910	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS07915	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK95_RS07920	COG1116	anion transmembrane transporter activity
CAK95_RS07935	COG0402	S-adenosylhomocysteine deaminase activity
CAK95_RS07970	COG0137	argininosuccinate synthase activity
CAK95_RS07985	COG0107	imidazoleglycerol-phosphate synthase activity
CAK95_RS07990	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CAK95_RS07995	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CAK95_RS08005	COG0131	Imidazoleglycerol-phosphate dehydratase
CAK95_RS08010	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CAK95_RS08020	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CAK95_RS08025	COG4771	TonB-dependent receptor
CAK95_RS08035	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
CAK95_RS08045	COG3030	protein affecting phage T7 exclusion by the F plasmid
CAK95_RS08050	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CAK95_RS08060	COG0237	dephospho-CoA kinase activity
CAK95_RS08065	COG0424	maF-like protein
CAK95_RS08070	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CAK95_RS08075	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CAK95_RS08080	COG2852	Protein conserved in bacteria
CAK95_RS08085	COG1981	membrane
CAK95_RS08090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CAK95_RS08100	COG5285	phytanoyl-CoA dioxygenase
CAK95_RS08115	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS08125	COG1331	Highly conserved protein containing a thioredoxin domain
CAK95_RS08135	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CAK95_RS08140	COG0445	tRNA wobble uridine modification
CAK95_RS08145	COG0357	Ribosomal RNA small subunit methyltransferase G
CAK95_RS08170	COG0495	leucyl-tRNA aminoacylation
CAK95_RS08200	COG0745	RESPONSE REGULATOR receiver
CAK95_RS08220	COG1253	flavin adenine dinucleotide binding
CAK95_RS08225	COG0129	dihydroxy-acid dehydratase activity
CAK95_RS08235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CAK95_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS08255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK95_RS08260	COG0024	Methionine aminopeptidase
CAK95_RS08265	COG2003	Belongs to the UPF0758 family
CAK95_RS08275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS08285	COG1280	lysine exporter protein (LysE YggA)
CAK95_RS08310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS08335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAK95_RS08340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS08355	COG4221	oxidoreductase activity
CAK95_RS08360	COG0519	Catalyzes the synthesis of GMP from XMP
CAK95_RS08360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAK95_RS08365	COG0251	oxidation-reduction process
CAK95_RS08380	COG2271	Major facilitator Superfamily
CAK95_RS08385	COG2202	Pas domain
CAK95_RS08385	COG3920	Histidine kinase
CAK95_RS08415	COG0729	surface antigen
CAK95_RS08445	COG0181	hydroxymethylbilane synthase activity
CAK95_RS08450	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CAK95_RS08455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CAK95_RS08465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CAK95_RS08470	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS08490	COG0138	bifunctional purine biosynthesis protein purh
CAK95_RS08495	COG2902	Dehydrogenase
CAK95_RS08505	COG0405	Gamma-glutamyltransferase
CAK95_RS08520	COG1704	LemA family
CAK95_RS08545	COG2835	tetraacyldisaccharide 4'-kinase activity
CAK95_RS08550	COG0625	glutathione transferase activity
CAK95_RS08555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS08560	COG1946	Acyl-CoA thioesterase
CAK95_RS08565	COG0347	Belongs to the P(II) protein family
CAK95_RS08570	COG0347	Belongs to the P(II) protein family
CAK95_RS08575	COG0004	ammonium transporteR
CAK95_RS08580	COG0596	Alpha beta hydrolase
CAK95_RS08590	COG0436	Aminotransferase
CAK95_RS08595	COG1674	ftsk spoiiie
CAK95_RS08605	COG1252	NADH dehydrogenase
CAK95_RS08635	COG2261	transglycosylase associated protein
CAK95_RS08650	COG0204	Acyl-transferase
CAK95_RS08650	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS08655	COG1309	transcriptional regulator
CAK95_RS08675	COG1872	DUF167
CAK95_RS08680	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAK95_RS08690	COG1247	-acetyltransferase
CAK95_RS08695	COG0583	DNA-binding transcription factor activity
CAK95_RS08715	COG1217	gtp-binding protein TYPA
CAK95_RS08720	COG2124	cytochrome p450
CAK95_RS08730	COG1994	Peptidase M50
CAK95_RS08730	COG0517	IMP dehydrogenase activity
CAK95_RS08735	COG2154	pterin-4-alpha-carbinolamine dehydratase
CAK95_RS08750	COG0583	DNA-binding transcription factor activity
CAK95_RS08760	COG3321	synthase
CAK95_RS08760	COG0604	alcohol dehydrogenase
CAK95_RS08760	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS08805	COG0140	phosphoribosyl-ATP diphosphatase activity
CAK95_RS08810	COG1072	(Pantothenic acid kinase))
CAK95_RS08820	COG5002	protein histidine kinase activity
CAK95_RS08820	COG2205	protein histidine kinase activity
CAK95_RS08820	COG0784	Response regulator, receiver
CAK95_RS08825	COG0606	chelatase, subunit chli
CAK95_RS08840	COG0189	ligase activity
CAK95_RS08850	COG0792	nuclease activity
CAK95_RS08855	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CAK95_RS08875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CAK95_RS08880	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CAK95_RS08895	COG1420	regulation of RNA biosynthetic process
CAK95_RS08900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CAK95_RS08915	COG0443	Heat shock 70 kDa protein
CAK95_RS08920	COG0484	heat shock protein binding
CAK95_RS08925	COG3963	phosphatidate phosphatase activity
CAK95_RS08935	COG0284	orotidine-5'-phosphate decarboxylase activity
CAK95_RS08950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CAK95_RS08955	COG0588	phosphoglycerate mutase activity
CAK95_RS08970	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CAK95_RS09000	COG0583	DNA-binding transcription factor activity
CAK95_RS09005	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CAK95_RS09015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CAK95_RS09015	COG0072	phenylalanine-tRNA ligase activity
CAK95_RS09025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CAK95_RS09030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CAK95_RS09035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CAK95_RS09050	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CAK95_RS09065	COG1024	Enoyl-CoA hydratase
CAK95_RS09075	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CAK95_RS09095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAK95_RS09095	COG4651	solute:proton antiporter activity
CAK95_RS09105	COG0735	belongs to the Fur family
CAK95_RS09110	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAK95_RS09125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAK95_RS09130	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CAK95_RS09135	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CAK95_RS09140	COG0583	DNA-binding transcription factor activity
CAK95_RS09145	COG1185	polyribonucleotide nucleotidyltransferase activity
CAK95_RS09150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CAK95_RS09155	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CAK95_RS09160	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CAK95_RS09165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CAK95_RS09180	COG0779	Required for maturation of 30S ribosomal subunits
CAK95_RS09190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CAK95_RS09195	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CAK95_RS09200	COG1396	sequence-specific DNA binding
CAK95_RS09205	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CAK95_RS09210	COG1253	flavin adenine dinucleotide binding
CAK95_RS09215	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CAK95_RS09220	COG1702	phosphate starvation-inducible protein PhoH
CAK95_RS09225	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAK95_RS09240	COG1214	PFAM Peptidase M22, glycoprotease
CAK95_RS09245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
CAK95_RS09255	COG0180	Tryptophanyl-tRNA synthetase
CAK95_RS09265	COG4941	Belongs to the sigma-70 factor family
CAK95_RS09270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAK95_RS09285	COG1414	Transcriptional regulator
CAK95_RS09300	COG0840	transmembrane signaling receptor activity
CAK95_RS09305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CAK95_RS09310	COG0488	(ABC) transporter
CAK95_RS09315	COG0477	Major facilitator Superfamily
CAK95_RS09320	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAK95_RS09325	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAK95_RS09330	COG1845	cytochrome c oxidase, subunit III
CAK95_RS09335	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CAK95_RS09350	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CAK95_RS09370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAK95_RS09380	COG1414	Transcriptional regulator
CAK95_RS09385	COG0028	Belongs to the TPP enzyme family
CAK95_RS09390	COG2855	membrane
CAK95_RS09395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CAK95_RS09405	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS09425	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS09430	COG0583	DNA-binding transcription factor activity
CAK95_RS09455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAK95_RS09465	COG0268	Binds directly to 16S ribosomal RNA
CAK95_RS09470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS09475	COG0280	phosphate acetyltransferase
CAK95_RS09475	COG0281	malic enzyme
CAK95_RS09490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAK95_RS09495	COG2862	Uncharacterized protein family, UPF0114
CAK95_RS09500	COG1596	polysaccharide export
CAK95_RS09505	COG0412	Dienelactone hydrolase
CAK95_RS09510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS09520	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS09520	COG1388	LysM domain
CAK95_RS09540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS09560	COG0473	3-isopropylmalate dehydrogenase activity
CAK95_RS09565	COG0583	DNA-binding transcription factor activity
CAK95_RS09595	COG2207	Transcriptional regulator
CAK95_RS09595	COG3708	Transcriptional regulator
CAK95_RS09605	COG2827	Endonuclease containing a URI domain
CAK95_RS09615	COG0534	Mate efflux family protein
CAK95_RS09625	COG2205	protein histidine kinase activity
CAK95_RS09630	COG2197	response regulator
CAK95_RS09660	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS09665	COG0411	ABC transporter
CAK95_RS09675	COG0431	NADPH-dependent FMN reductase
CAK95_RS09685	COG0798	PFAM Bile acid sodium symporter
CAK95_RS09705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK95_RS09715	COG0640	Transcriptional regulator
CAK95_RS09720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAK95_RS09750	COG0346	lactoylglutathione lyase activity
CAK95_RS09755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAK95_RS09760	COG0247	lactate metabolic process
CAK95_RS09760	COG0277	FAD linked oxidase domain protein
CAK95_RS09775	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CAK95_RS09780	COG3387	PFAM Glycoside hydrolase 15-related
CAK95_RS09785	COG1877	trehalose-phosphatase activity
CAK95_RS09795	COG0673	inositol 2-dehydrogenase activity
CAK95_RS09815	COG3237	CsbD-like
CAK95_RS09830	COG1234	tRNA 3'-trailer cleavage
CAK95_RS09840	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS09845	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
CAK95_RS09885	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS09890	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS09895	COG1129	ABC transporter
CAK95_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS09925	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS09935	COG0251	oxidation-reduction process
CAK95_RS09940	COG1309	transcriptional regulator
CAK95_RS09945	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS09950	COG2814	Major facilitator Superfamily
CAK95_RS09985	COG2186	Transcriptional regulator
CAK95_RS10015	COG0683	leucine binding
CAK95_RS10020	COG0683	leucine binding
CAK95_RS10030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS10060	COG1414	Transcriptional regulator
CAK95_RS10065	COG1063	alcohol dehydrogenase
CAK95_RS10100	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAK95_RS10155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS10165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS10170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS10180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS10195	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS10205	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CAK95_RS10215	COG2030	dehydratase
CAK95_RS10230	COG2814	Major facilitator Superfamily
CAK95_RS10235	COG1566	PFAM secretion protein HlyD family protein
CAK95_RS10240	COG1846	Transcriptional regulator
CAK95_RS10245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS10250	COG0837	glucose binding
CAK95_RS10260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CAK95_RS10270	COG0735	belongs to the Fur family
CAK95_RS10275	COG0697	spore germination
CAK95_RS10280	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CAK95_RS10290	COG0577	efflux transmembrane transporter activity
CAK95_RS10290	COG1136	(ABC) transporter
CAK95_RS10295	COG1136	(ABC) transporter
CAK95_RS10300	COG1566	PFAM secretion protein HlyD family protein
CAK95_RS10305	COG0142	geranyltranstransferase activity
CAK95_RS10310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CAK95_RS10315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CAK95_RS10325	COG0405	Gamma-glutamyltransferase
CAK95_RS10335	COG5001	Diguanylate cyclase
CAK95_RS10335	COG3300	MHYT domain
CAK95_RS10340	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
CAK95_RS10345	COG0183	Belongs to the thiolase family
CAK95_RS10365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK95_RS10380	COG2890	protein-(glutamine-N5) methyltransferase activity
CAK95_RS10385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CAK95_RS10400	COG0527	aspartate kinase activity
CAK95_RS10405	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK95_RS10420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAK95_RS10430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAK95_RS10440	COG1040	competence protein
CAK95_RS10455	COG0494	nUDIX hydrolase
CAK95_RS10460	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CAK95_RS10465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAK95_RS10470	COG0653	protein targeting
CAK95_RS10480	COG3034	peptidoglycan biosynthetic process
CAK95_RS10485	COG0825	malonyl-CoA metabolic process
CAK95_RS10490	COG4974	Belongs to the 'phage' integrase family
CAK95_RS10500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CAK95_RS10505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CAK95_RS10510	COG4536	flavin adenine dinucleotide binding
CAK95_RS10545	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CAK95_RS10560	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CAK95_RS10565	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CAK95_RS10570	COG1329	Transcriptional regulator
CAK95_RS10575	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CAK95_RS10580	COG3119	arylsulfatase activity
CAK95_RS10585	COG0561	phosphatase activity
CAK95_RS10615	COG2828	Protein conserved in bacteria
CAK95_RS10620	COG1335	isochorismatase
CAK95_RS10625	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS10650	COG0251	oxidation-reduction process
CAK95_RS10655	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
CAK95_RS10670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS10680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS10715	COG2368	4-hydroxyphenylacetate
CAK95_RS10735	COG2835	tetraacyldisaccharide 4'-kinase activity
CAK95_RS10745	COG2226	methyltransferase
CAK95_RS10770	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAK95_RS10775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK95_RS10780	COG2197	response regulator
CAK95_RS10790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK95_RS10805	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
CAK95_RS10815	COG4310	Domain of unknown function (DUF2172)
CAK95_RS10835	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAK95_RS10840	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS10850	COG4771	TonB-dependent receptor
CAK95_RS10860	COG4558	Periplasmic binding protein
CAK95_RS10865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CAK95_RS10870	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CAK95_RS10890	COG0071	Belongs to the small heat shock protein (HSP20) family
CAK95_RS10900	COG0659	secondary active sulfate transmembrane transporter activity
CAK95_RS10915	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CAK95_RS10920	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS10925	COG0450	alkyl hydroperoxide reductase
CAK95_RS10935	COG0539	negative regulation of cytoplasmic translation
CAK95_RS10940	COG0616	signal peptide processing
CAK95_RS10945	COG0776	regulation of translation
CAK95_RS10955	COG2423	ornithine cyclodeaminase activity
CAK95_RS10960	COG0135	phosphoribosylanthranilate isomerase activity
CAK95_RS10965	COG0133	tryptophan synthase activity
CAK95_RS10970	COG0159	tryptophan synthase activity
CAK95_RS10975	COG1132	(ABC) transporter
CAK95_RS10990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CAK95_RS10995	COG0285	dihydrofolate synthase activity
CAK95_RS11000	COG1793	dna ligase
CAK95_RS11010	COG1074	ATP-dependent DNA helicase activity
CAK95_RS11020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CAK95_RS11025	COG3178	'Phosphotransferase
CAK95_RS11030	COG2205	protein histidine kinase activity
CAK95_RS11040	COG0756	dUTP diphosphatase activity
CAK95_RS11045	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CAK95_RS11050	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK95_RS11055	COG2226	methyltransferase
CAK95_RS11060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CAK95_RS11070	COG5487	UPF0391 membrane protein
CAK95_RS11080	COG0784	Response regulator, receiver
CAK95_RS11095	COG2202	Pas domain
CAK95_RS11095	COG3920	Histidine kinase
CAK95_RS11110	COG1063	alcohol dehydrogenase
CAK95_RS11115	COG1704	LemA family
CAK95_RS11145	COG0142	geranyltranstransferase activity
CAK95_RS11150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CAK95_RS11165	COG1573	uracil-dna glycosylase
CAK95_RS11170	COG2252	PERMEase
CAK95_RS11175	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK95_RS11180	COG1271	oxidase subunit
CAK95_RS11185	COG1294	oxidase, subunit
CAK95_RS11195	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CAK95_RS11215	COG1846	Transcriptional regulator
CAK95_RS11215	COG0456	acetyltransferase
CAK95_RS11220	COG2346	COG2346, Truncated hemoglobins
CAK95_RS11230	COG0521	Mo-molybdopterin cofactor biosynthetic process
CAK95_RS11235	COG2321	neutral zinc metallopeptidase
CAK95_RS11240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CAK95_RS11250	COG0251	oxidation-reduction process
CAK95_RS11260	COG3685	Protein conserved in bacteria
CAK95_RS11270	COG1283	sodium-dependent phosphate transmembrane transporter activity
CAK95_RS11280	COG0288	reversible hydration of carbon dioxide
CAK95_RS11285	COG1194	a g-specific adenine glycosylase
CAK95_RS11295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAK95_RS11300	COG1196	nuclear chromosome segregation
CAK95_RS11305	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAK95_RS11310	COG5328	Belongs to the UPF0262 family
CAK95_RS11320	COG0424	maF-like protein
CAK95_RS11325	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CAK95_RS11340	COG0582	viral genome integration into host DNA
CAK95_RS11355	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS11400	COG2186	Transcriptional regulator
CAK95_RS11405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS11410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS11430	COG0582	viral genome integration into host DNA
CAK95_RS11450	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS11460	COG1024	Enoyl-CoA hydratase
CAK95_RS11470	COG4172	Belongs to the ABC transporter superfamily
CAK95_RS11475	COG0601	transmembrane transport
CAK95_RS11485	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAK95_RS11495	COG1024	Enoyl-CoA hydratase
CAK95_RS11500	COG0604	alcohol dehydrogenase
CAK95_RS11505	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS11505	COG1024	Enoyl-CoA hydratase
CAK95_RS11510	COG0183	Belongs to the thiolase family
CAK95_RS11530	COG1309	transcriptional regulator
CAK95_RS11575	COG1175	transmembrane transport
CAK95_RS11610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CAK95_RS11620	COG2010	Cytochrome c
CAK95_RS11620	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CAK95_RS11645	COG1309	transcriptional regulator
CAK95_RS11765	COG1522	sequence-specific DNA binding
CAK95_RS11815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAK95_RS11835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAK95_RS11840	COG2205	protein histidine kinase activity
CAK95_RS11840	COG4999	Histidine kinase
CAK95_RS11840	COG3437	response regulator, receiver
CAK95_RS11840	COG3850	Histidine kinase
CAK95_RS11875	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAK95_RS11875	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CAK95_RS11890	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS11905	COG0604	alcohol dehydrogenase
CAK95_RS11915	COG0840	transmembrane signaling receptor activity
CAK95_RS11935	COG2096	Adenosyltransferase
CAK95_RS11940	COG2086	electron transfer activity
CAK95_RS11945	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CAK95_RS11950	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS12015	COG5507	3-demethylubiquinone-9 3-methyltransferase
CAK95_RS12040	COG0625	glutathione transferase activity
CAK95_RS12065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CAK95_RS12070	COG0165	Argininosuccinate lyase
CAK95_RS12080	COG0019	diaminopimelate decarboxylase activity
CAK95_RS12105	COG0784	Response regulator, receiver
CAK95_RS12105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK95_RS12105	COG2198	Histidine kinase
CAK95_RS12105	COG2205	protein histidine kinase activity
CAK95_RS12115	COG2884	Cell division ATP-binding protein ftsE
CAK95_RS12145	COG0287	Prephenate dehydrogenase
CAK95_RS12150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CAK95_RS12160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAK95_RS12165	COG2813	Specifically methylates the guanine in position
CAK95_RS12165	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAK95_RS12175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CAK95_RS12185	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CAK95_RS12190	COG0706	membrane insertase activity
CAK95_RS12195	COG0594	ribonuclease P activity
CAK95_RS12200	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CAK95_RS12205	COG4191	Histidine kinase
CAK95_RS12215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS12235	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS12250	COG0583	DNA-binding transcription factor activity
CAK95_RS12265	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS12275	COG1024	Enoyl-CoA hydratase
CAK95_RS12300	COG3383	formate dehydrogenase (NAD+) activity
CAK95_RS12305	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CAK95_RS12355	COG0683	leucine binding
CAK95_RS12360	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS12370	COG0411	ABC transporter
CAK95_RS12380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS12385	COG3473	Maleate cis-trans isomerase
CAK95_RS12390	COG0596	Alpha beta hydrolase
CAK95_RS12395	COG2309	aminopeptidase activity
CAK95_RS12400	COG1335	isochorismatase
CAK95_RS12410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK95_RS12425	COG1672	PFAM Archaeal ATPase
CAK95_RS12425	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
CAK95_RS12445	COG0730	response to heat
CAK95_RS12470	COG3069	C4-dicarboxylate transmembrane transporter activity
CAK95_RS12490	COG0405	Gamma-glutamyltransferase
CAK95_RS12495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS12500	COG1116	anion transmembrane transporter activity
CAK95_RS12510	COG1335	isochorismatase
CAK95_RS12515	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAK95_RS12520	COG2146	nitrite reductase [NAD(P)H] activity
CAK95_RS12530	COG2815	serine threonine protein kinase
CAK95_RS12530	COG0515	serine threonine protein kinase
CAK95_RS12550	COG4638	Rieske (2fe-2S)
CAK95_RS12565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS12570	COG0840	transmembrane signaling receptor activity
CAK95_RS12575	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAK95_RS12575	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CAK95_RS12580	COG5001	Diguanylate cyclase
CAK95_RS12580	COG3300	MHYT domain
CAK95_RS12620	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CAK95_RS12645	COG1840	ABC-type Fe3 transport system, periplasmic component
CAK95_RS12655	COG2205	protein histidine kinase activity
CAK95_RS12690	COG1609	Transcriptional regulator
CAK95_RS12695	COG0683	leucine binding
CAK95_RS12700	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS12710	COG1696	Membrane protein involved in D-alanine export
CAK95_RS12745	COG1802	Transcriptional regulator
CAK95_RS12755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS12760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CAK95_RS12765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CAK95_RS12770	COG0625	glutathione transferase activity
CAK95_RS12785	COG3383	formate dehydrogenase (NAD+) activity
CAK95_RS12790	COG0583	DNA-binding transcription factor activity
CAK95_RS12800	COG2175	clavaminate synthase activity
CAK95_RS12805	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAK95_RS12820	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CAK95_RS12825	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAK95_RS12830	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CAK95_RS12840	COG1993	acr, cog1993
CAK95_RS12845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CAK95_RS12850	COG1335	isochorismatase
CAK95_RS12860	COG0800	Aldolase
CAK95_RS12875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CAK95_RS12890	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAK95_RS12895	COG0523	cobalamin synthesis protein
CAK95_RS12905	COG0583	DNA-binding transcription factor activity
CAK95_RS12915	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS12920	COG0583	DNA-binding transcription factor activity
CAK95_RS12950	COG0339	signal peptide processing
CAK95_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS12980	COG2271	Major facilitator Superfamily
CAK95_RS13000	COG1022	Amp-dependent synthetase and ligase
CAK95_RS13035	COG2738	Putative neutral zinc metallopeptidase
CAK95_RS13040	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS13045	COG0277	FAD linked oxidase domain protein
CAK95_RS13050	COG0247	lactate metabolic process
CAK95_RS13080	COG4178	(ABC) transporter
CAK95_RS13085	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAK95_RS13095	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS13105	COG0154	amidase activity
CAK95_RS13110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAK95_RS13125	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
CAK95_RS13150	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
CAK95_RS13155	COG0459	protein refolding
CAK95_RS13160	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAK95_RS13170	COG1392	Phosphate transport regulator
CAK95_RS13175	COG0306	phosphate transporter
CAK95_RS13195	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS13200	COG3416	Protein conserved in bacteria
CAK95_RS13210	COG0463	Glycosyl transferase, family 2
CAK95_RS13225	COG2233	PERMEase
CAK95_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS13240	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CAK95_RS13245	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CAK95_RS13260	COG0124	histidyl-tRNA synthetase
CAK95_RS13265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CAK95_RS13270	COG0463	Glycosyl transferase, family 2
CAK95_RS13290	COG0745	RESPONSE REGULATOR receiver
CAK95_RS13295	COG2030	dehydratase
CAK95_RS13300	COG0196	riboflavin kinase activity
CAK95_RS13305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CAK95_RS13320	COG0612	Peptidase, M16
CAK95_RS13325	COG0612	Peptidase, M16
CAK95_RS13330	COG0166	Belongs to the GPI family
CAK95_RS13345	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CAK95_RS13350	COG0742	ribosomal rna small subunit methyltransferase
CAK95_RS13355	COG1187	pseudouridine synthase activity
CAK95_RS13360	COG0590	tRNA wobble adenosine to inosine editing
CAK95_RS13365	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAK95_RS13375	COG0596	Alpha beta hydrolase
CAK95_RS13380	COG0151	Belongs to the GarS family
CAK95_RS13385	COG1570	exodeoxyribonuclease VII activity
CAK95_RS13400	COG1663	tetraacyldisaccharide 4'-kinase activity
CAK95_RS13405	COG1519	Transferase
CAK95_RS13420	COG0483	inositol monophosphate 1-phosphatase activity
CAK95_RS13425	COG0312	modulator of DNA gyrase
CAK95_RS13435	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAK95_RS13455	COG0673	inositol 2-dehydrogenase activity
CAK95_RS13460	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS13475	COG2030	dehydratase
CAK95_RS13485	COG0012	GTP binding
CAK95_RS13495	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CAK95_RS13505	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CAK95_RS13515	COG1496	oxidoreductase activity
CAK95_RS13525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CAK95_RS13535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CAK95_RS13550	COG0697	spore germination
CAK95_RS13570	COG2001	Belongs to the MraZ family
CAK95_RS13575	COG0275	rRNA processing
CAK95_RS13590	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CAK95_RS13595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAK95_RS13600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CAK95_RS13605	COG1121	(ABC) transporter
CAK95_RS13610	COG0803	Belongs to the bacterial solute-binding protein 9 family
CAK95_RS13640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CAK95_RS13655	COG5002	protein histidine kinase activity
CAK95_RS13655	COG2176	DNA-directed DNA polymerase activity
CAK95_RS13670	COG0601	transmembrane transport
CAK95_RS13690	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS13700	COG1131	(ABC) transporter
CAK95_RS13705	COG0842	Transport permease protein
CAK95_RS13710	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CAK95_RS13720	COG0277	FAD linked oxidase domain protein
CAK95_RS13725	COG2391	methyltransferase activity
CAK95_RS13740	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAK95_RS13745	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAK95_RS13750	COG0583	DNA-binding transcription factor activity
CAK95_RS13755	COG0492	ferredoxin-NADP+ reductase activity
CAK95_RS13760	COG1522	sequence-specific DNA binding
CAK95_RS13765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS13780	COG2259	Doxx family
CAK95_RS13790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAK95_RS13795	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CAK95_RS13800	COG1295	ribonuclease BN
CAK95_RS13835	COG0505	Belongs to the CarA family
CAK95_RS13840	COG1742	UPF0060 membrane protein
CAK95_RS13865	COG0583	DNA-binding transcription factor activity
CAK95_RS13880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS13905	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CAK95_RS13920	COG0583	DNA-binding transcription factor activity
CAK95_RS13950	COG2226	methyltransferase
CAK95_RS13960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAK95_RS13980	COG3739	integral membrane protein
CAK95_RS14015	COG1280	lysine exporter protein (LysE YggA)
CAK95_RS14020	COG0583	DNA-binding transcription factor activity
CAK95_RS14085	COG1597	lipid kinase activity
CAK95_RS14090	COG1573	uracil-dna glycosylase
CAK95_RS14115	COG1301	dicarboxylic acid transport
CAK95_RS14135	COG4974	Belongs to the 'phage' integrase family
CAK95_RS14160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS14180	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS14185	COG1335	isochorismatase
CAK95_RS14190	COG0596	Alpha beta hydrolase
CAK95_RS14195	COG2309	aminopeptidase activity
CAK95_RS14245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS14245	COG1116	anion transmembrane transporter activity
CAK95_RS14285	COG1309	transcriptional regulator
CAK95_RS14305	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS14315	COG0583	DNA-binding transcription factor activity
CAK95_RS14325	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS14345	COG0154	amidase activity
CAK95_RS14350	COG0582	viral genome integration into host DNA
CAK95_RS14385	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK95_RS14395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK95_RS14485	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CAK95_RS14495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAK95_RS14505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CAK95_RS14530	COG0210	DNA helicase
CAK95_RS14545	COG0277	FAD linked oxidase domain protein
CAK95_RS14565	COG0114	fumarate hydratase activity
CAK95_RS14605	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CAK95_RS14615	COG0330	HflC and HflK could
CAK95_RS14620	COG0330	HflC and HflK could
CAK95_RS14630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS14635	COG0560	Phosphoserine phosphatase
CAK95_RS14635	COG3830	Belongs to the UPF0237 family
CAK95_RS14645	COG2442	InterPro IPR007367
CAK95_RS14650	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CAK95_RS14665	COG3237	CsbD-like
CAK95_RS14675	COG0028	Belongs to the TPP enzyme family
CAK95_RS14680	COG0440	acetolactate synthase activity
CAK95_RS14690	COG1959	2 iron, 2 sulfur cluster binding
CAK95_RS14695	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CAK95_RS14700	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CAK95_RS14705	COG4208	sulfate ABC transporter
CAK95_RS14710	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAK95_RS14715	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CAK95_RS14720	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS14725	COG0517	IMP dehydrogenase activity
CAK95_RS14725	COG1125	glycine betaine transport
CAK95_RS14730	COG1174	glycine betaine transport
CAK95_RS14740	COG1846	Transcriptional regulator
CAK95_RS14755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS14780	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CAK95_RS14785	COG0384	phenazine biosynthesis protein PhzF
CAK95_RS14795	COG2326	polyphosphate kinase activity
CAK95_RS14800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAK95_RS14835	COG1172	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS14850	COG1137	ATPase activity
CAK95_RS14880	COG0145	ligase activity
CAK95_RS14890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS14900	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CAK95_RS14905	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS14910	COG1802	Transcriptional regulator
CAK95_RS14920	COG1116	anion transmembrane transporter activity
CAK95_RS14920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS14925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS14940	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS14965	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS14975	COG1024	Enoyl-CoA hydratase
CAK95_RS14980	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS14985	COG3246	L-lysine catabolic process to acetate
CAK95_RS14990	COG3258	Cytochrome c
CAK95_RS15030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAK95_RS15065	COG1233	COG1233 Phytoene dehydrogenase and related
CAK95_RS15070	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS15075	COG1917	Cupin 2, conserved barrel domain protein
CAK95_RS15095	COG0411	ABC transporter
CAK95_RS15130	COG1218	3'(2'),5'-bisphosphate nucleotidase
CAK95_RS15140	COG2198	Histidine kinase
CAK95_RS15140	COG0643	Histidine kinase
CAK95_RS15150	COG2201	protein-glutamate methylesterase activity
CAK95_RS15155	COG2201	protein-glutamate methylesterase activity
CAK95_RS15205	COG1054	Belongs to the UPF0176 family
CAK95_RS15220	COG0745	RESPONSE REGULATOR receiver
CAK95_RS15255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CAK95_RS15265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAK95_RS15280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS15330	COG2204	response regulator
CAK95_RS15335	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAK95_RS15345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CAK95_RS15350	COG1766	The M ring may be actively involved in energy transduction
CAK95_RS15375	COG0482	sulfurtransferase activity
CAK95_RS15400	COG1595	DNA-templated transcription, initiation
CAK95_RS15410	COG3424	synthase
CAK95_RS15415	COG1755	Isoprenylcysteine carboxyl methyltransferase
CAK95_RS15435	COG2814	Major facilitator Superfamily
CAK95_RS15440	COG4191	Histidine kinase
CAK95_RS15455	COG2140	Oxalate decarboxylase
CAK95_RS15470	COG4566	intracellular signal transduction
CAK95_RS15475	COG4566	intracellular signal transduction
CAK95_RS15495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK95_RS15535	COG0583	DNA-binding transcription factor activity
CAK95_RS15545	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS15565	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS15580	COG2249	NAD(P)H dehydrogenase (quinone) activity
CAK95_RS15585	COG0167	dihydroorotate dehydrogenase activity
CAK95_RS15590	COG1414	Transcriptional regulator
CAK95_RS15610	COG0411	ABC transporter
CAK95_RS15635	COG0583	DNA-binding transcription factor activity
CAK95_RS15640	COG3618	amidohydrolase
CAK95_RS15675	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
CAK95_RS15695	COG0519	Catalyzes the synthesis of GMP from XMP
CAK95_RS15705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK95_RS15720	COG2816	NAD+ diphosphatase activity
CAK95_RS15725	COG2135	peptidase activity
CAK95_RS15750	COG0009	L-threonylcarbamoyladenylate synthase
CAK95_RS15760	COG0277	FAD linked oxidase domain protein
CAK95_RS15790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK95_RS15800	COG0501	Belongs to the peptidase M48B family
CAK95_RS15810	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS15825	COG1408	metallophosphoesterase
CAK95_RS15830	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS15830	COG1388	LysM domain
CAK95_RS15835	COG0598	Magnesium transport protein CorA
CAK95_RS15840	COG2207	Transcriptional regulator
CAK95_RS15850	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS15855	COG0259	pyridoxamine-phosphate oxidase activity
CAK95_RS15865	COG0484	heat shock protein binding
CAK95_RS15880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CAK95_RS15890	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CAK95_RS15895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAK95_RS15895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CAK95_RS15905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CAK95_RS15910	COG0534	Mate efflux family protein
CAK95_RS15915	COG4178	(ABC) transporter
CAK95_RS15925	COG1722	exodeoxyribonuclease VII activity
CAK95_RS15930	COG0123	including yeast histone deacetylase and acetoin utilization protein
CAK95_RS15960	COG3622	Belongs to the hyi family
CAK95_RS15970	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAK95_RS15995	COG2951	lytic endotransglycosylase activity
CAK95_RS16025	COG1022	Amp-dependent synthetase and ligase
CAK95_RS16035	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS16045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK95_RS16050	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS16060	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAK95_RS16065	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
CAK95_RS16070	COG0535	radical SAM domain protein
CAK95_RS16075	COG0535	radical SAM domain protein
CAK95_RS16120	COG0411	ABC transporter
CAK95_RS16185	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS16190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CAK95_RS16235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CAK95_RS16250	COG3011	Protein conserved in bacteria
CAK95_RS16255	COG0492	ferredoxin-NADP+ reductase activity
CAK95_RS16270	COG4221	oxidoreductase activity
CAK95_RS16280	COG2207	Transcriptional regulator
CAK95_RS16290	COG1733	regulation of RNA biosynthetic process
CAK95_RS16300	COG0556	nucleotide-excision repair
CAK95_RS16335	COG1132	(ABC) transporter
CAK95_RS16345	COG2267	carboxylic ester hydrolase activity
CAK95_RS16365	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS16380	COG2133	pyrroloquinoline quinone binding
CAK95_RS16390	COG0625	glutathione transferase activity
CAK95_RS16395	COG0436	Aminotransferase
CAK95_RS16405	COG0737	Belongs to the 5'-nucleotidase family
CAK95_RS16410	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CAK95_RS16420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CAK95_RS16425	COG2951	lytic endotransglycosylase activity
CAK95_RS16440	COG0070	glutamate synthase
CAK95_RS16440	COG0069	glutamate synthase activity
CAK95_RS16440	COG0067	glutamate synthase
CAK95_RS16450	COG1733	regulation of RNA biosynthetic process
CAK95_RS16455	COG2910	NAD(P)H-binding
CAK95_RS16490	COG0483	inositol monophosphate 1-phosphatase activity
CAK95_RS16515	COG0531	amino acid
CAK95_RS16520	COG2264	protein methyltransferase activity
CAK95_RS16535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CAK95_RS16540	COG3063	Type IV pilus biogenesis stability protein PilW
CAK95_RS16550	COG0469	pyruvate kinase activity
CAK95_RS16575	COG3750	Belongs to the UPF0335 family
CAK95_RS16580	COG0667	Aldo Keto reductase
CAK95_RS16585	COG2814	Major facilitator Superfamily
CAK95_RS16595	COG0154	amidase activity
CAK95_RS16600	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS16610	COG3845	ABC transporter
CAK95_RS16620	COG1414	Transcriptional regulator
CAK95_RS16625	COG1174	glycine betaine transport
CAK95_RS16630	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CAK95_RS16695	COG2217	Heavy metal translocating P-type atpase
CAK95_RS16710	COG2010	Cytochrome c
CAK95_RS16725	COG3278	Belongs to the heme-copper respiratory oxidase family
CAK95_RS16745	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CAK95_RS16750	COG4191	Histidine kinase
CAK95_RS16755	COG4566	intracellular signal transduction
CAK95_RS16790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS16795	COG1129	ABC transporter
CAK95_RS16795	COG0842	Transport permease protein
CAK95_RS16800	COG0842	Transport permease protein
CAK95_RS16815	COG2084	Dehydrogenase
CAK95_RS16820	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAK95_RS16825	COG0022	dehydrogenase e1 component
CAK95_RS16830	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK95_RS16840	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS16850	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS16850	COG0604	alcohol dehydrogenase
CAK95_RS16850	COG3321	synthase
CAK95_RS16860	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CAK95_RS16870	COG3842	ATPase activity
CAK95_RS16875	COG1177	transmembrane transport
CAK95_RS16880	COG1176	ABC-type spermidine putrescine transport system, permease component I
CAK95_RS16885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CAK95_RS16895	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAK95_RS16900	COG2368	4-hydroxyphenylacetate
CAK95_RS16910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAK95_RS16915	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAK95_RS16920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS16945	COG0747	negative chemotaxis
CAK95_RS16950	COG0601	transmembrane transport
CAK95_RS16955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAK95_RS16960	COG4172	Belongs to the ABC transporter superfamily
CAK95_RS16980	COG1802	Transcriptional regulator
CAK95_RS16990	COG3707	response regulator
CAK95_RS16995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS17000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS17005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS17010	COG1116	anion transmembrane transporter activity
CAK95_RS17020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAK95_RS17025	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAK95_RS17030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
CAK95_RS17035	COG0243	molybdopterin cofactor binding
CAK95_RS17040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAK95_RS17040	COG1648	precorrin-2 dehydrogenase activity
CAK95_RS17050	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS17080	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS17090	COG1024	Enoyl-CoA hydratase
CAK95_RS17095	COG2079	MmgE PrpD family protein
CAK95_RS17100	COG1414	Transcriptional regulator
CAK95_RS17105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAK95_RS17110	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAK95_RS17110	COG1902	pentaerythritol trinitrate reductase activity
CAK95_RS17130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS17135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS17140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CAK95_RS17155	COG0523	cobalamin synthesis protein
CAK95_RS17180	COG1309	transcriptional regulator
CAK95_RS17185	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS17195	COG0235	Class ii aldolase
CAK95_RS17225	COG0656	L-ascorbic acid biosynthetic process
CAK95_RS17255	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CAK95_RS17275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CAK95_RS17280	COG2186	Transcriptional regulator
CAK95_RS17305	COG1129	ABC transporter
CAK95_RS17315	COG0829	nickel cation binding
CAK95_RS17320	COG0831	urea catabolic process
CAK95_RS17330	COG0832	Belongs to the urease beta subunit family
CAK95_RS17335	COG0804	urea catabolic process
CAK95_RS17345	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CAK95_RS17350	COG0830	nickel cation binding
CAK95_RS17360	COG3327	negative regulation of DNA-templated transcription, initiation
CAK95_RS17365	COG3396	Phenylacetate-CoA oxygenase
CAK95_RS17370	COG3460	Phenylacetate-CoA oxygenase
CAK95_RS17375	COG3396	Phenylacetate-CoA oxygenase
CAK95_RS17380	COG2151	metal-sulfur cluster biosynthetic enzyme
CAK95_RS17385	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CAK95_RS17400	COG2050	protein possibly involved in aromatic compounds catabolism
CAK95_RS17405	COG1024	Enoyl-CoA hydratase
CAK95_RS17410	COG1012	belongs to the aldehyde dehydrogenase family
CAK95_RS17415	COG0683	leucine binding
CAK95_RS17420	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS17440	COG1522	sequence-specific DNA binding
CAK95_RS17465	COG4214	carbohydrate transport
CAK95_RS17470	COG0411	ABC transporter
CAK95_RS17500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS17515	COG1802	Transcriptional regulator
CAK95_RS17525	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS17530	COG3550	peptidyl-serine autophosphorylation
CAK95_RS17540	COG1132	(ABC) transporter
CAK95_RS17585	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CAK95_RS17590	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CAK95_RS17595	COG0859	PFAM glycosyl transferase family 9
CAK95_RS17600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK95_RS17605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CAK95_RS17605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CAK95_RS17615	COG0463	Glycosyl transferase, family 2
CAK95_RS17630	COG0859	PFAM glycosyl transferase family 9
CAK95_RS17635	COG1086	Polysaccharide biosynthesis protein
CAK95_RS17640	COG0702	epimerase
CAK95_RS17645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CAK95_RS17675	COG1083	cytidylyl-transferase
CAK95_RS17695	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK95_RS17700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CAK95_RS17705	COG2089	acid synthase
CAK95_RS17710	COG0297	glycogen (starch) synthase activity
CAK95_RS17715	COG1132	(ABC) transporter
CAK95_RS17730	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAK95_RS17730	COG2755	lipolytic protein G-D-S-L family
CAK95_RS17745	COG0367	asparagine synthase
CAK95_RS17750	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS17775	COG0673	inositol 2-dehydrogenase activity
CAK95_RS17810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS17810	COG2010	Cytochrome c
CAK95_RS17840	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS17845	COG0351	phosphomethylpyrimidine kinase
CAK95_RS17880	COG2814	Major facilitator Superfamily
CAK95_RS17890	COG0667	Aldo Keto reductase
CAK95_RS17895	COG2814	Major facilitator Superfamily
CAK95_RS17900	COG0583	DNA-binding transcription factor activity
CAK95_RS17920	COG3218	ABC-type transport auxiliary lipoprotein component
CAK95_RS17920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CAK95_RS17925	COG1127	ABC transporter
CAK95_RS17930	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CAK95_RS17935	COG4948	Mandelate Racemase Muconate Lactonizing
CAK95_RS17980	COG0633	Ferredoxin
CAK95_RS17985	COG0633	Ferredoxin
CAK95_RS17990	COG0492	ferredoxin-NADP+ reductase activity
CAK95_RS17995	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CAK95_RS17995	COG2755	lipolytic protein G-D-S-L family
CAK95_RS18015	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS18020	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS18020	COG2010	Cytochrome c
CAK95_RS18025	COG2080	2 iron, 2 sulfur cluster binding
CAK95_RS18035	COG1671	Belongs to the UPF0178 family
CAK95_RS18085	COG3685	Protein conserved in bacteria
CAK95_RS18110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CAK95_RS18115	COG0542	response to heat
CAK95_RS18120	COG1749	Flagellar hook protein flgE
CAK95_RS18140	COG5443	negative regulation of bacterial-type flagellum assembly
CAK95_RS18150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CAK95_RS18170	COG1706	bacterial-type flagellum-dependent cell motility
CAK95_RS18185	COG0475	glutathione-regulated potassium exporter activity
CAK95_RS18185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CAK95_RS18195	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CAK95_RS18205	COG4786	Flagellar basal body rod
CAK95_RS18210	COG4786	Flagellar basal body rod
CAK95_RS18240	COG4774	siderophore transport
CAK95_RS18255	COG4774	siderophore transport
CAK95_RS18265	COG1338	Plays a role in the flagellum-specific transport system
CAK95_RS18280	COG1558	bacterial-type flagellum-dependent cell motility
CAK95_RS18285	COG1677	Flagellar hook-basal body complex protein FliE
CAK95_RS18290	COG1987	bacterial-type flagellum assembly
CAK95_RS18295	COG1684	flagellar biosynthetic protein fliR
CAK95_RS18300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CAK95_RS18355	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS18415	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CAK95_RS18415	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CAK95_RS18430	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS18435	COG2358	TRAP transporter, solute receptor (TAXI family
CAK95_RS18445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS18475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CAK95_RS18475	COG0517	IMP dehydrogenase activity
CAK95_RS18475	COG0617	tRNA 3'-terminal CCA addition
CAK95_RS18490	COG3220	belongs to the UPF0276 family
CAK95_RS18530	COG3273	potassium ion transport
CAK95_RS18530	COG0471	metal ion transport
CAK95_RS18535	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS18555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS18560	COG0596	Alpha beta hydrolase
CAK95_RS18580	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CAK95_RS18595	COG5001	Diguanylate cyclase
CAK95_RS18595	COG3300	MHYT domain
CAK95_RS18600	COG0625	glutathione transferase activity
CAK95_RS18605	COG3258	Cytochrome c
CAK95_RS18660	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS18670	COG1902	pentaerythritol trinitrate reductase activity
CAK95_RS18685	COG0463	Glycosyl transferase, family 2
CAK95_RS18705	COG1703	isobutyryl-CoA mutase activity
CAK95_RS18740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CAK95_RS18750	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CAK95_RS18765	COG0433	COG0433 Predicted ATPase
CAK95_RS18800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CAK95_RS18810	COG4957	zinc ion binding
CAK95_RS18825	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CAK95_RS18840	COG2166	iron-sulfur cluster assembly
CAK95_RS18850	COG2205	protein histidine kinase activity
CAK95_RS18895	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAK95_RS18900	COG2983	Belongs to the UPF0260 family
CAK95_RS18905	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAK95_RS18920	COG0477	Major facilitator Superfamily
CAK95_RS18930	COG0477	Major facilitator Superfamily
CAK95_RS18965	COG4695	Portal protein
CAK95_RS19030	COG0679	Auxin Efflux Carrier
CAK95_RS19130	COG0778	Nitroreductase
CAK95_RS19160	COG4235	cytochrome complex assembly
CAK95_RS19165	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
CAK95_RS19170	COG1138	Cytochrome C-type biogenesis protein
CAK95_RS19175	COG3088	subunit of a heme lyase
CAK95_RS19180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS19190	COG2205	protein histidine kinase activity
CAK95_RS19195	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CAK95_RS19200	COG2202	Pas domain
CAK95_RS19200	COG2205	protein histidine kinase activity
CAK95_RS19205	COG0308	aminopeptidase N
CAK95_RS19230	COG1477	protein flavinylation
CAK95_RS19290	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS19305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CAK95_RS19335	COG1429	ligase activity, forming nitrogen-metal bonds
CAK95_RS19435	COG4227	nucleotidyltransferase activity
CAK95_RS19475	COG5489	Protein of unknown function (DUF736)
CAK95_RS19575	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK95_RS19585	COG4962	Type ii secretion system protein e
CAK95_RS19600	COG3451	type IV secretory pathway VirB4
CAK95_RS19630	COG2948	multi-organism process
CAK95_RS19640	COG0789	Transcriptional regulator
CAK95_RS19680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS19685	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK95_RS19720	COG2226	methyltransferase
CAK95_RS19725	COG3034	peptidoglycan biosynthetic process
CAK95_RS19740	COG0789	Transcriptional regulator
CAK95_RS19745	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CAK95_RS19765	COG0785	Cytochrome C biogenesis protein
CAK95_RS19785	COG0730	response to heat
CAK95_RS19800	COG2202	Pas domain
CAK95_RS19800	COG2205	protein histidine kinase activity
CAK95_RS19805	COG0625	glutathione transferase activity
CAK95_RS19820	COG2084	Dehydrogenase
CAK95_RS19850	COG3128	pkhd-type hydroxylase
CAK95_RS19860	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAK95_RS19865	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS19880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CAK95_RS19890	COG0531	amino acid
CAK95_RS19895	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS19925	COG0546	phosphoglycolate phosphatase activity
CAK95_RS19930	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CAK95_RS19955	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CAK95_RS19960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CAK95_RS19990	COG2124	cytochrome p450
CAK95_RS19995	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CAK95_RS20000	COG0513	Belongs to the DEAD box helicase family
CAK95_RS20020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS20035	COG0784	Response regulator, receiver
CAK95_RS20035	COG4191	Histidine kinase
CAK95_RS20045	COG0215	cysteine-tRNA ligase activity
CAK95_RS20055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CAK95_RS20070	COG5265	(ABC) transporter
CAK95_RS20075	COG0688	phosphatidylethanolamine metabolic process
CAK95_RS20080	COG1183	phosphatidylcholine synthase activity
CAK95_RS20085	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CAK95_RS20105	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CAK95_RS20115	COG3158	transport of potassium into the cell
CAK95_RS20125	COG0864	Transcriptional regulator
CAK95_RS20135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAK95_RS20150	COG1063	alcohol dehydrogenase
CAK95_RS20155	COG2814	Major facilitator Superfamily
CAK95_RS20160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK95_RS20165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK95_RS20170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAK95_RS20175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAK95_RS20195	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CAK95_RS20205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CAK95_RS20215	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAK95_RS20245	COG3191	aminopeptidase activity
CAK95_RS20250	COG0785	Cytochrome C biogenesis protein
CAK95_RS20260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK95_RS20265	COG1846	Transcriptional regulator
CAK95_RS20275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAK95_RS20280	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CAK95_RS20285	COG0683	leucine binding
CAK95_RS20330	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS20335	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CAK95_RS20340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CAK95_RS20355	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS20365	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS20390	COG2514	catechol 2,3-dioxygenase activity
CAK95_RS20395	COG0542	response to heat
CAK95_RS20410	COG3608	succinylglutamate desuccinylase aspartoacylase
CAK95_RS20410	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CAK95_RS20415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAK95_RS20420	COG1309	transcriptional regulator
CAK95_RS20425	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS20430	COG1131	(ABC) transporter
CAK95_RS20485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CAK95_RS20505	COG0662	Cupin 2, conserved barrel domain protein
CAK95_RS20520	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CAK95_RS20535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS20550	COG0596	Alpha beta hydrolase
CAK95_RS20555	COG0459	protein refolding
CAK95_RS20560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CAK95_RS20565	COG5425	PFAM Usg family protein
CAK95_RS20575	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS20590	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CAK95_RS20595	COG2199	diguanylate cyclase activity
CAK95_RS20600	COG0300	oxidoreductase activity
CAK95_RS20605	COG5001	Diguanylate cyclase
CAK95_RS20605	COG3300	MHYT domain
CAK95_RS20625	COG2308	Evidence 4 Homologs of previously reported genes of
CAK95_RS20630	COG1058	Belongs to the CinA family
CAK95_RS20630	COG1546	Belongs to the CinA family
CAK95_RS20635	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS20640	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CAK95_RS20650	COG0784	Response regulator, receiver
CAK95_RS20650	COG4191	Histidine kinase
CAK95_RS20675	COG1937	Protein conserved in bacteria
CAK95_RS20680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CAK95_RS20700	COG2267	carboxylic ester hydrolase activity
CAK95_RS20755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CAK95_RS20755	COG0617	tRNA 3'-terminal CCA addition
CAK95_RS20755	COG0517	IMP dehydrogenase activity
CAK95_RS20760	COG1752	Esterase of the alpha-beta hydrolase superfamily
CAK95_RS20765	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CAK95_RS20770	COG0778	Nitroreductase
CAK95_RS20780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CAK95_RS20785	COG4191	Histidine kinase
CAK95_RS20785	COG0784	Response regulator, receiver
CAK95_RS20795	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CAK95_RS20820	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CAK95_RS20820	COG0546	phosphoglycolate phosphatase activity
CAK95_RS20830	COG0302	gtp cyclohydrolase
CAK95_RS20835	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CAK95_RS20855	COG2301	Belongs to the HpcH HpaI aldolase family
CAK95_RS20895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CAK95_RS20900	COG1324	tolerance protein
CAK95_RS20935	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS20945	COG2140	Oxalate decarboxylase
CAK95_RS20960	COG1802	Transcriptional regulator
CAK95_RS21015	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CAK95_RS21020	COG0747	negative chemotaxis
CAK95_RS21030	COG0154	amidase activity
CAK95_RS21060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS21090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS21115	COG0330	HflC and HflK could
CAK95_RS21125	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS21130	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS21135	COG4598	ABC transporter
CAK95_RS21140	COG0765	amino acid transport
CAK95_RS21145	COG0765	amino acid transport
CAK95_RS21150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK95_RS21165	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CAK95_RS21175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CAK95_RS21180	COG0081	regulation of translation
CAK95_RS21210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CAK95_RS21225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CAK95_RS21240	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CAK95_RS21245	COG0049	tRNA binding
CAK95_RS21250	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CAK95_RS21255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CAK95_RS21260	COG0051	transcription antitermination factor activity, RNA binding
CAK95_RS21265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CAK95_RS21270	COG0088	Forms part of the polypeptide exit tunnel
CAK95_RS21275	COG0089	rRNA binding
CAK95_RS21280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CAK95_RS21285	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CAK95_RS21290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CAK95_RS21295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CAK95_RS21300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CAK95_RS21310	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CAK95_RS21315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CAK95_RS21320	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CAK95_RS21325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CAK95_RS21330	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CAK95_RS21335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CAK95_RS21340	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CAK95_RS21345	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CAK95_RS21350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CAK95_RS21355	COG1841	ribosomal large subunit assembly
CAK95_RS21360	COG0200	Binds to the 23S rRNA
CAK95_RS21365	COG0201	protein transport
CAK95_RS21370	COG0563	adenylate kinase activity
CAK95_RS21375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CAK95_RS21380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CAK95_RS21385	COG0202	RNA polymerase activity
CAK95_RS21390	COG0203	ribosomal protein L17
CAK95_RS21405	COG1733	regulation of RNA biosynthetic process
CAK95_RS21425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS21430	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CAK95_RS21460	COG0640	Transcriptional regulator
CAK95_RS21485	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CAK95_RS21490	COG1834	amidinotransferase
CAK95_RS21495	COG1013	pyruvate-flavodoxin oxidoreductase activity
CAK95_RS21500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CAK95_RS21500	COG0674	pyruvate-flavodoxin oxidoreductase activity
CAK95_RS21505	COG0493	'glutamate synthase
CAK95_RS21510	COG0546	phosphoglycolate phosphatase activity
CAK95_RS21525	COG0783	Belongs to the Dps family
CAK95_RS21560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK95_RS21660	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CAK95_RS21670	COG2050	protein possibly involved in aromatic compounds catabolism
CAK95_RS21675	COG0400	carboxylic ester hydrolase activity
CAK95_RS21680	COG0450	alkyl hydroperoxide reductase
CAK95_RS21690	COG4770	biotin carboxylase activity
CAK95_RS21705	COG1254	Belongs to the acylphosphatase family
CAK95_RS21710	COG0321	lipoyl(octanoyl) transferase activity
CAK95_RS21725	COG2239	Acts as a magnesium transporter
CAK95_RS21735	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS21740	COG4689	acetoacetate decarboxylase
CAK95_RS21745	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS21760	COG0656	L-ascorbic acid biosynthetic process
CAK95_RS21765	COG0656	L-ascorbic acid biosynthetic process
CAK95_RS21780	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CAK95_RS21780	COG0473	3-isopropylmalate dehydrogenase activity
CAK95_RS21785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CAK95_RS21810	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CAK95_RS21825	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CAK95_RS21850	COG1234	tRNA 3'-trailer cleavage
CAK95_RS21895	COG3485	protocatechuate 3,4-dioxygenase
CAK95_RS21905	COG2066	Belongs to the glutaminase family
CAK95_RS21915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CAK95_RS21920	COG1192	Involved in chromosome partitioning
CAK95_RS21935	COG1686	Belongs to the peptidase S11 family
CAK95_RS21950	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CAK95_RS21960	COG3384	dioxygenase
CAK95_RS21965	COG0625	glutathione transferase activity
CAK95_RS21970	COG0523	cobalamin synthesis protein
CAK95_RS21990	COG0537	adenosine 5'-monophosphoramidase activity
CAK95_RS22015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CAK95_RS22025	COG0784	Response regulator, receiver
CAK95_RS22035	COG1234	tRNA 3'-trailer cleavage
CAK95_RS22040	COG0583	DNA-binding transcription factor activity
CAK95_RS22045	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CAK95_RS22060	COG0557	exoribonuclease II activity
CAK95_RS22065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CAK95_RS22075	COG0758	DNA mediated transformation
CAK95_RS22085	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CAK95_RS22090	COG0540	Belongs to the ATCase OTCase family
CAK95_RS22095	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS22145	COG0300	oxidoreductase activity
CAK95_RS22170	COG3239	Fatty acid desaturase
CAK95_RS22195	COG0590	tRNA wobble adenosine to inosine editing
CAK95_RS22210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CAK95_RS22225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
CAK95_RS22235	COG0629	single-stranded DNA binding
CAK95_RS22240	COG2095	MarC family integral membrane protein
CAK95_RS22245	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAK95_RS22255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CAK95_RS22270	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CAK95_RS22275	COG0343	queuine tRNA-ribosyltransferase activity
CAK95_RS22290	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS22300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS22305	COG0582	viral genome integration into host DNA
CAK95_RS22325	COG1758	RNA polymerase activity
CAK95_RS22335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CAK95_RS22340	COG0736	holo-[acyl-carrier-protein] synthase activity
CAK95_RS22350	COG0571	ribonuclease III activity
CAK95_RS22355	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CAK95_RS22365	COG1381	Involved in DNA repair and RecF pathway recombination
CAK95_RS22375	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CAK95_RS22380	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CAK95_RS22390	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CAK95_RS22395	COG0113	porphobilinogen synthase activity
CAK95_RS22400	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS22405	COG1024	Enoyl-CoA hydratase
CAK95_RS22420	COG1846	Transcriptional regulator
CAK95_RS22430	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CAK95_RS22435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CAK95_RS22440	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAK95_RS22440	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CAK95_RS22450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CAK95_RS22455	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CAK95_RS22460	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CAK95_RS22465	COG1304	FMN binding
CAK95_RS22470	COG2814	Major facilitator Superfamily
CAK95_RS22480	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS22490	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CAK95_RS22510	COG0416	fatty acid biosynthetic process
CAK95_RS22515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAK95_RS22520	COG0776	regulation of translation
CAK95_RS22560	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS22590	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS22605	COG0726	polysaccharide deacetylase
CAK95_RS22615	COG1612	heme a metabolic process
CAK95_RS22640	COG1832	CoA-binding protein
CAK95_RS22645	COG1024	Enoyl-CoA hydratase
CAK95_RS22655	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CAK95_RS22660	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CAK95_RS22675	COG0174	glutamine synthetase
CAK95_RS22680	COG0347	Belongs to the P(II) protein family
CAK95_RS22685	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CAK95_RS22685	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CAK95_RS22690	COG2132	Multicopper oxidase
CAK95_RS22700	COG0544	peptidyl-prolyl cis-trans isomerase activity
CAK95_RS22705	COG0740	serine-type endopeptidase activity
CAK95_RS22710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CAK95_RS22715	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAK95_RS22735	COG0848	biopolymer transport protein
CAK95_RS22745	COG4774	siderophore transport
CAK95_RS22750	COG3128	pkhd-type hydroxylase
CAK95_RS22760	COG0776	regulation of translation
CAK95_RS22805	COG3768	UPF0283 membrane protein
CAK95_RS22810	COG3106	COG3106 Predicted ATPase
CAK95_RS22830	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAK95_RS22835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAK95_RS22845	COG0649	NAD binding
CAK95_RS22850	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CAK95_RS22855	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
CAK95_RS22865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CAK95_RS22870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CAK95_RS22880	COG0713	ATP synthesis coupled electron transport
CAK95_RS22895	COG1007	ATP synthesis coupled electron transport
CAK95_RS22910	COG0346	lactoylglutathione lyase activity
CAK95_RS22925	COG0442	prolyl-tRNA aminoacylation
CAK95_RS22935	COG1136	(ABC) transporter
CAK95_RS22945	COG1902	pentaerythritol trinitrate reductase activity
CAK95_RS22955	COG0052	Belongs to the universal ribosomal protein uS2 family
CAK95_RS22960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CAK95_RS22965	COG0528	UMP kinase activity
CAK95_RS22970	COG0233	cytoplasmic translational termination
CAK95_RS22975	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CAK95_RS22985	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CAK95_RS22990	COG0750	zinc metalloprotease
CAK95_RS22995	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CAK95_RS23000	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAK95_RS23005	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CAK95_RS23010	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAK95_RS23015	COG3494	Protein of unknown function (DUF1009)
CAK95_RS23020	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CAK95_RS23025	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CAK95_RS23045	COG0372	Belongs to the citrate synthase family
CAK95_RS23050	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAK95_RS23055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CAK95_RS23065	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CAK95_RS23070	COG0303	'Molybdopterin
CAK95_RS23075	COG0315	cyclic pyranopterin monophosphate synthase activity
CAK95_RS23080	COG0134	indole-3-glycerol-phosphate synthase activity
CAK95_RS23085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CAK95_RS23105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CAK95_RS23110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CAK95_RS23115	COG0149	triose-phosphate isomerase activity
CAK95_RS23125	COG0504	CTP synthase activity
CAK95_RS23135	COG0402	S-adenosylhomocysteine deaminase activity
CAK95_RS23140	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CAK95_RS23145	COG2814	Major facilitator Superfamily
CAK95_RS23150	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CAK95_RS23165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
CAK95_RS23170	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK95_RS23170	COG0022	dehydrogenase e1 component
CAK95_RS23175	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK95_RS23190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CAK95_RS23205	COG3275	phosphorelay sensor kinase activity
CAK95_RS23220	COG3360	Dodecin
CAK95_RS23225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CAK95_RS23230	COG2867	negative regulation of translational initiation
CAK95_RS23235	COG1546	Belongs to the CinA family
CAK95_RS23235	COG1058	Belongs to the CinA family
CAK95_RS23240	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CAK95_RS23240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CAK95_RS23255	COG2204	response regulator
CAK95_RS23260	COG5000	phosphorelay sensor kinase activity
CAK95_RS23265	COG2204	response regulator
CAK95_RS23270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CAK95_RS23275	COG1923	regulation of RNA biosynthetic process
CAK95_RS23280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CAK95_RS23285	COG3956	TIGRFAM MazG family protein
CAK95_RS23300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CAK95_RS23300	COG0321	lipoyl(octanoyl) transferase activity
CAK95_RS23305	COG0084	hydrolase, TatD family'
CAK95_RS23325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CAK95_RS23330	COG1686	Belongs to the peptidase S11 family
CAK95_RS23425	COG0640	Transcriptional regulator
CAK95_RS23450	COG3258	Cytochrome c
CAK95_RS23465	COG0737	Belongs to the 5'-nucleotidase family
CAK95_RS23485	COG0446	pyridine nucleotide-disulphide oxidoreductase
CAK95_RS23520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CAK95_RS23525	COG5001	Diguanylate cyclase
CAK95_RS23525	COG2203	Gaf domain
CAK95_RS23525	COG4251	negative regulation of phosphorylation
CAK95_RS23525	COG3706	GGDEF domain
CAK95_RS23545	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS23550	COG0861	Integral membrane protein TerC family
CAK95_RS23555	COG1183	phosphatidylcholine synthase activity
CAK95_RS23560	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CAK95_RS23570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS23575	COG0679	Auxin Efflux Carrier
CAK95_RS23580	COG2301	Belongs to the HpcH HpaI aldolase family
CAK95_RS23625	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CAK95_RS23630	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CAK95_RS23640	COG3152	Membrane
CAK95_RS23650	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CAK95_RS23655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CAK95_RS23685	COG1473	amidohydrolase
CAK95_RS23740	COG0741	lytic transglycosylase activity
CAK95_RS23745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS23750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CAK95_RS23775	COG0625	glutathione transferase activity
CAK95_RS23790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAK95_RS23805	COG0154	amidase activity
CAK95_RS23815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CAK95_RS23820	COG0583	DNA-binding transcription factor activity
CAK95_RS23845	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CAK95_RS23870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CAK95_RS23875	COG1862	Preprotein translocase
CAK95_RS23890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAK95_RS23895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CAK95_RS23900	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CAK95_RS23905	COG0805	protein transport
CAK95_RS23910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAK95_RS23915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CAK95_RS23920	COG3842	ATPase activity
CAK95_RS23925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CAK95_RS23930	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CAK95_RS23935	COG1472	Belongs to the glycosyl hydrolase 3 family
CAK95_RS23945	COG0018	arginyl-trna synthetase
CAK95_RS23950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CAK95_RS23970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CAK95_RS23975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS23980	COG0708	Exodeoxyribonuclease III
CAK95_RS23985	COG3795	YCII-related domain
CAK95_RS24000	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS24010	COG1388	LysM domain
CAK95_RS24010	COG1376	ErfK ybiS ycfS ynhG family protein
CAK95_RS24025	COG0129	dihydroxy-acid dehydratase activity
CAK95_RS24040	COG2094	Belongs to the DNA glycosylase MPG family
CAK95_RS24045	COG1368	sulfuric ester hydrolase activity
CAK95_RS24055	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS24060	COG0702	epimerase
CAK95_RS24070	COG0525	valine-tRNA ligase activity
CAK95_RS24090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CAK95_RS24105	COG0840	transmembrane signaling receptor activity
CAK95_RS24130	COG4948	Mandelate Racemase Muconate Lactonizing
CAK95_RS24135	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS24160	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS24170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS24190	COG2897	thiosulfate sulfurtransferase activity
CAK95_RS24195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK95_RS24195	COG3453	Protein conserved in bacteria
CAK95_RS24200	COG1126	abc transporter atp-binding protein
CAK95_RS24205	COG0765	amino acid transport
CAK95_RS24210	COG4597	amino acid ABC transporter
CAK95_RS24215	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK95_RS24220	COG0626	cystathionine gamma-synthase activity
CAK95_RS24235	COG0463	Glycosyl transferase, family 2
CAK95_RS24245	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CAK95_RS24250	COG4953	penicillin-binding protein 1C
CAK95_RS24255	COG2373	Large extracellular alpha-helical protein
CAK95_RS24285	COG0625	glutathione transferase activity
CAK95_RS24465	COG0740	serine-type endopeptidase activity
CAK95_RS24490	COG0250	Participates in transcription elongation, termination and antitermination
CAK95_RS24635	COG3916	Acyl-homoserine-lactone synthase
CAK95_RS24640	COG2197	response regulator
CAK95_RS24655	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CAK95_RS24685	COG0175	sulfate reduction
CAK95_RS24695	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CAK95_RS24705	COG1648	precorrin-2 dehydrogenase activity
CAK95_RS24705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CAK95_RS24745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS24775	COG1494	fructose-1,6-bisphosphatase
CAK95_RS24785	COG0436	Aminotransferase
CAK95_RS24795	COG3243	poly(R)-hydroxyalkanoic acid synthase
CAK95_RS24815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CAK95_RS24820	COG0730	response to heat
CAK95_RS24825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CAK95_RS24835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CAK95_RS24845	COG0586	Pfam SNARE associated Golgi protein
CAK95_RS24850	COG0187	DNA topoisomerase II activity
CAK95_RS24855	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CAK95_RS24870	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS24895	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS24905	COG1181	Belongs to the D-alanine--D-alanine ligase family
CAK95_RS24910	COG0626	cystathionine gamma-synthase activity
CAK95_RS24915	COG4303	Ethanolamine ammonia lyase large subunit
CAK95_RS24920	COG4302	ethanolamine ammonia-lyase activity
CAK95_RS24930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CAK95_RS24935	COG1136	(ABC) transporter
CAK95_RS24935	COG0577	efflux transmembrane transporter activity
CAK95_RS24940	COG1136	(ABC) transporter
CAK95_RS24945	COG0596	Alpha beta hydrolase
CAK95_RS24950	COG0513	Belongs to the DEAD box helicase family
CAK95_RS24955	COG3706	GGDEF domain
CAK95_RS24970	COG0316	Belongs to the HesB IscA family
CAK95_RS24975	COG0346	lactoylglutathione lyase activity
CAK95_RS24985	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CAK95_RS24990	COG0719	Fe-S assembly protein
CAK95_RS24995	COG0396	ATPase activity
CAK95_RS25005	COG0719	Fe-S assembly protein
CAK95_RS25015	COG2945	thiolester hydrolase activity
CAK95_RS25020	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CAK95_RS25020	COG0662	Cupin 2, conserved barrel domain protein
CAK95_RS25025	COG4178	(ABC) transporter
CAK95_RS25030	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CAK95_RS25035	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CAK95_RS25045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CAK95_RS25050	COG0739	heme binding
CAK95_RS25060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CAK95_RS25140	COG1530	ribonuclease E activity
CAK95_RS25140	COG1530	ribonuclease E activity
CAK95_RS25145	COG3347	Dehydrogenase
CAK95_RS25145	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS25155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CAK95_RS25160	COG0840	transmembrane signaling receptor activity
CAK95_RS25165	COG0835	chemotaxis
CAK95_RS25170	COG0840	transmembrane signaling receptor activity
CAK95_RS25205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS25210	COG0586	Pfam SNARE associated Golgi protein
CAK95_RS25225	COG0436	Aminotransferase
CAK95_RS25235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CAK95_RS25240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CAK95_RS25245	COG0511	ligase activity, forming carbon-carbon bonds
CAK95_RS25250	COG0439	Biotin carboxylase
CAK95_RS25265	COG1309	transcriptional regulator
CAK95_RS25280	COG1030	water channel activity
CAK95_RS25285	COG0330	HflC and HflK could
CAK95_RS25290	COG4191	Histidine kinase
CAK95_RS25290	COG0784	Response regulator, receiver
CAK95_RS25295	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CAK95_RS25310	COG2814	Major facilitator Superfamily
CAK95_RS25340	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CAK95_RS25360	COG1733	regulation of RNA biosynthetic process
CAK95_RS25375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CAK95_RS25390	COG0443	Heat shock 70 kDa protein
CAK95_RS25430	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS25430	COG1024	Enoyl-CoA hydratase
CAK95_RS25465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS25500	COG1846	Transcriptional regulator
CAK95_RS25505	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
CAK95_RS25565	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CAK95_RS25580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CAK95_RS25595	COG3045	CreA protein
CAK95_RS25650	COG2200	EAL domain
CAK95_RS25655	COG1741	Belongs to the pirin family
CAK95_RS25670	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CAK95_RS25675	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CAK95_RS25680	COG0281	malic enzyme
CAK95_RS25680	COG0280	phosphate acetyltransferase
CAK95_RS25685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CAK95_RS25695	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
CAK95_RS25705	COG3384	dioxygenase
CAK95_RS25715	COG0583	DNA-binding transcription factor activity
CAK95_RS25720	COG0248	Ppx GppA phosphatase
CAK95_RS25725	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CAK95_RS25735	COG0628	permease
CAK95_RS25740	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CAK95_RS25745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CAK95_RS25750	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CAK95_RS25755	COG1278	Cold shock
CAK95_RS25765	COG0243	molybdopterin cofactor binding
CAK95_RS25770	COG0861	Integral membrane protein TerC family
CAK95_RS25800	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS25805	COG0488	(ABC) transporter
CAK95_RS25830	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CAK95_RS25845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CAK95_RS25855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CAK95_RS25860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CAK95_RS25870	COG0194	GDP metabolic process
CAK95_RS25875	COG1561	YicC-like family, N-terminal region
CAK95_RS25880	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CAK95_RS25885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CAK95_RS25890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CAK95_RS25900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CAK95_RS25910	COG0360	Binds together with S18 to 16S ribosomal RNA
CAK95_RS25915	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CAK95_RS25925	COG0359	binds to the 23S rRNA
CAK95_RS25935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CAK95_RS25940	COG0305	Participates in initiation and elongation during chromosome replication
CAK95_RS25945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CAK95_RS25960	COG1286	toxin biosynthetic process
CAK95_RS25965	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CAK95_RS25990	COG1595	DNA-templated transcription, initiation
CAK95_RS26035	COG1160	GTP binding
CAK95_RS26050	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAK95_RS26080	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CAK95_RS26090	COG0583	DNA-binding transcription factor activity
CAK95_RS26095	COG0583	DNA-binding transcription factor activity
CAK95_RS26100	COG1024	Enoyl-CoA hydratase
CAK95_RS26115	COG0741	lytic transglycosylase activity
CAK95_RS26115	COG1196	nuclear chromosome segregation
CAK95_RS26115	COG0739	heme binding
CAK95_RS26120	COG0583	DNA-binding transcription factor activity
CAK95_RS26130	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS26145	COG1393	Belongs to the ArsC family
CAK95_RS26150	COG0640	Transcriptional regulator
CAK95_RS26165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS26180	COG0596	Alpha beta hydrolase
CAK95_RS26185	COG0583	DNA-binding transcription factor activity
CAK95_RS26190	COG0667	Aldo Keto reductase
CAK95_RS26200	COG0183	Belongs to the thiolase family
CAK95_RS26210	COG2080	2 iron, 2 sulfur cluster binding
CAK95_RS26215	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
CAK95_RS26220	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS26250	COG0583	DNA-binding transcription factor activity
CAK95_RS26255	COG0668	transmembrane transport
CAK95_RS26260	COG2020	methyltransferase activity
CAK95_RS26270	COG1309	transcriptional regulator
CAK95_RS26275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CAK95_RS26275	COG0519	Catalyzes the synthesis of GMP from XMP
CAK95_RS26290	COG2130	NADP-dependent
CAK95_RS26315	COG0784	Response regulator, receiver
CAK95_RS26315	COG4191	Histidine kinase
CAK95_RS26325	COG0477	Major facilitator Superfamily
CAK95_RS26330	COG0776	regulation of translation
CAK95_RS26355	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS26380	COG2066	Belongs to the glutaminase family
CAK95_RS26390	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CAK95_RS26395	COG1846	Transcriptional regulator
CAK95_RS26405	COG0174	glutamine synthetase
CAK95_RS26415	COG1032	radical SAM domain protein
CAK95_RS26425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS26440	COG0745	RESPONSE REGULATOR receiver
CAK95_RS26450	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CAK95_RS26455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CAK95_RS26465	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CAK95_RS26470	COG5001	Diguanylate cyclase
CAK95_RS26470	COG3300	MHYT domain
CAK95_RS26505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAK95_RS26515	COG0047	phosphoribosylformylglycinamidine synthase activity
CAK95_RS26525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CAK95_RS26530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CAK95_RS26565	COG2188	Transcriptional regulator
CAK95_RS26575	COG0538	isocitrate dehydrogenase activity
CAK95_RS26580	COG0584	glycerophosphoryl diester phosphodiesterase
CAK95_RS26595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CAK95_RS26600	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CAK95_RS26655	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS26665	COG0175	sulfate reduction
CAK95_RS26690	COG0444	Belongs to the ABC transporter superfamily
CAK95_RS26695	COG0154	amidase activity
CAK95_RS26705	COG4608	Belongs to the ABC transporter superfamily
CAK95_RS26710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAK95_RS26720	COG0747	negative chemotaxis
CAK95_RS26740	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CAK95_RS26745	COG2814	Major facilitator Superfamily
CAK95_RS26750	COG2326	polyphosphate kinase activity
CAK95_RS26755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CAK95_RS26760	COG3387	PFAM Glycoside hydrolase 15-related
CAK95_RS26765	COG0300	oxidoreductase activity
CAK95_RS26775	COG2124	cytochrome p450
CAK95_RS26790	COG1032	radical SAM domain protein
CAK95_RS26805	COG0156	8-amino-7-oxononanoate synthase activity
CAK95_RS26810	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS26810	COG3321	synthase
CAK95_RS26810	COG0604	alcohol dehydrogenase
CAK95_RS26825	COG0438	transferase activity, transferring glycosyl groups
CAK95_RS26825	COG1216	Glycosyl transferase, family 2
CAK95_RS26845	COG1088	dTDP-glucose 4,6-dehydratase activity
CAK95_RS26860	COG3754	Rhamnan synthesis protein F
CAK95_RS26905	COG1216	Glycosyl transferase, family 2
CAK95_RS26905	COG0463	Glycosyl transferase, family 2
CAK95_RS27045	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CAK95_RS27060	COG2267	carboxylic ester hydrolase activity
CAK95_RS27065	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS27070	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS27080	COG1250	3-hydroxyacyl-CoA dehydrogenase
CAK95_RS27090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CAK95_RS27120	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS27135	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS27160	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS27165	COG1960	acyl-CoA dehydrogenase activity
CAK95_RS27170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CAK95_RS27175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CAK95_RS27190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CAK95_RS27195	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS27210	COG0625	glutathione transferase activity
CAK95_RS27230	COG2188	Transcriptional regulator
CAK95_RS27285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS27295	COG0583	DNA-binding transcription factor activity
CAK95_RS27305	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CAK95_RS27310	COG1917	Cupin 2, conserved barrel domain protein
CAK95_RS27325	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CAK95_RS27345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS27350	COG1116	anion transmembrane transporter activity
CAK95_RS27355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS27365	COG4638	Rieske (2fe-2S)
CAK95_RS27375	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CAK95_RS27390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CAK95_RS27395	COG2188	Transcriptional regulator
CAK95_RS27405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CAK95_RS27415	COG0747	negative chemotaxis
CAK95_RS27420	COG3321	synthase
CAK95_RS27420	COG0604	alcohol dehydrogenase
CAK95_RS27430	COG0300	oxidoreductase activity
CAK95_RS27435	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CAK95_RS27450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CAK95_RS27475	COG1396	sequence-specific DNA binding
CAK95_RS27480	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CAK95_RS27485	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CAK95_RS27500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CAK95_RS27505	COG0489	protein tyrosine kinase activity
CAK95_RS27515	COG1596	polysaccharide export
CAK95_RS27545	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CAK95_RS27555	COG4948	Mandelate Racemase Muconate Lactonizing
CAK95_RS27570	COG1309	transcriptional regulator
CAK95_RS27575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CAK95_RS27585	COG2205	protein histidine kinase activity
CAK95_RS27590	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CAK95_RS27595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CAK95_RS27600	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CAK95_RS27620	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS27625	COG2207	Transcriptional regulator
CAK95_RS27640	COG0410	ABC transporter
CAK95_RS27730	COG0596	Alpha beta hydrolase
CAK95_RS27740	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS27755	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS27760	COG1137	ATPase activity
CAK95_RS27825	COG0437	4 iron, 4 sulfur cluster binding
CAK95_RS27830	COG0243	molybdopterin cofactor binding
CAK95_RS27830	COG3383	formate dehydrogenase (NAD+) activity
CAK95_RS27875	COG4249	Peptidase C14 caspase catalytic subunit p20
CAK95_RS27875	COG2319	Wd-40 repeat
CAK95_RS27885	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CAK95_RS27890	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CAK95_RS27895	COG3454	Phosphonate metabolism
CAK95_RS27900	COG4778	phosphonate C-P lyase system protein PhnL
CAK95_RS27905	COG4107	phosphonate C-P lyase system protein PhnK
CAK95_RS27910	COG3627	carbon phosphorus lyase activity
CAK95_RS27915	COG3626	phosphonate metabolism
CAK95_RS27920	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
CAK95_RS27925	COG3624	Phosphonate C-P lyase system protein PhnG
CAK95_RS27930	COG2188	Transcriptional regulator
CAK95_RS27935	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CAK95_RS27940	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
CAK95_RS27945	COG3639	organic phosphonate transmembrane transporter activity
CAK95_RS27955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
CAK95_RS27970	COG2261	transglycosylase associated protein
CAK95_RS27980	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS27980	COG2010	Cytochrome c
CAK95_RS27990	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CAK95_RS27995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CAK95_RS28035	COG0501	Belongs to the peptidase M48B family
CAK95_RS28045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CAK95_RS28055	COG1695	Transcriptional regulator
CAK95_RS28075	COG1278	Cold shock
CAK95_RS28085	COG0564	pseudouridine synthase activity
CAK95_RS28090	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CAK95_RS28120	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CAK95_RS28125	COG0697	spore germination
CAK95_RS28135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CAK95_RS28195	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CAK95_RS28200	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CAK95_RS28210	COG1304	FMN binding
CAK95_RS28215	COG1309	transcriptional regulator
CAK95_RS28225	COG2027	D-alanyl-D-alanine carboxypeptidase
CAK95_RS28270	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS28275	COG3181	Tripartite tricarboxylate transporter family receptor
CAK95_RS28305	COG0824	Thioesterase
CAK95_RS28325	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CAK95_RS28330	COG1116	anion transmembrane transporter activity
CAK95_RS28335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS28340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS28345	COG3604	Transcriptional regulator
CAK95_RS28360	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS28370	COG0179	Fumarylacetoacetate (FAA) hydrolase
CAK95_RS28375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CAK95_RS28415	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CAK95_RS28425	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS28445	COG3657	addiction module killer protein
CAK95_RS28455	COG2204	response regulator
CAK95_RS28465	COG3108	Peptidase M15
CAK95_RS28520	COG0784	Response regulator, receiver
CAK95_RS28520	COG2198	Histidine kinase
CAK95_RS28520	COG5002	protein histidine kinase activity
CAK95_RS28530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CAK95_RS28535	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CAK95_RS28550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CAK95_RS28555	COG1414	Transcriptional regulator
CAK95_RS28570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CAK95_RS28610	COG1079	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS28620	COG3845	ABC transporter
CAK95_RS28630	COG0402	S-adenosylhomocysteine deaminase activity
CAK95_RS28655	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS28660	COG0583	DNA-binding transcription factor activity
CAK95_RS28665	COG0402	S-adenosylhomocysteine deaminase activity
CAK95_RS28670	COG0318	PFAM AMP-dependent synthetase and ligase
CAK95_RS28705	COG1129	ABC transporter
CAK95_RS28715	COG0559	Belongs to the binding-protein-dependent transport system permease family
CAK95_RS28730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CAK95_RS28750	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CAK95_RS28760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CAK95_RS28800	COG0431	NADPH-dependent FMN reductase
CAK95_RS28820	COG0596	Alpha beta hydrolase
CAK95_RS28820	COG0508	dehydrogenase complex catalyzes the overall conversion of
CAK95_RS28825	COG1028	Short-chain dehydrogenase reductase Sdr
CAK95_RS28855	COG0517	IMP dehydrogenase activity
CAK95_RS28855	COG4175	Glycine betaine
CAK95_RS28875	COG0596	Alpha beta hydrolase
CAK95_RS28910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs