locus-tag	class	description
H4W19_RS00010	COG3275	phosphorelay sensor kinase activity
H4W19_RS00020	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4W19_RS00025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4W19_RS00070	COG3540	Alkaline phosphatase
H4W19_RS00080	COG3300	MHYT domain
H4W19_RS00080	COG5001	Diguanylate cyclase
H4W19_RS00085	COG3040	lipid binding
H4W19_RS00100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4W19_RS00110	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H4W19_RS00170	COG5507	3-demethylubiquinone-9 3-methyltransferase
H4W19_RS00240	COG2259	Doxx family
H4W19_RS00295	COG5001	Diguanylate cyclase
H4W19_RS00295	COG5002	protein histidine kinase activity
H4W19_RS00300	COG1187	pseudouridine synthase activity
H4W19_RS00330	COG0477	Major facilitator Superfamily
H4W19_RS00340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
H4W19_RS00375	COG0477	Major facilitator Superfamily
H4W19_RS00380	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4W19_RS00385	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4W19_RS00390	COG1845	cytochrome c oxidase, subunit III
H4W19_RS00395	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
H4W19_RS00410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4W19_RS00425	COG1695	Transcriptional regulator
H4W19_RS00445	COG1981	membrane
H4W19_RS00450	COG1785	Belongs to the alkaline phosphatase family
H4W19_RS00455	COG1301	dicarboxylic acid transport
H4W19_RS00465	COG0385	Bile acid
H4W19_RS00470	COG0791	NLP P60 protein
H4W19_RS00475	COG0791	NLP P60 protein
H4W19_RS00485	COG2311	Membrane
H4W19_RS00490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W19_RS00510	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
H4W19_RS00525	COG0504	CTP synthase activity
H4W19_RS00530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H4W19_RS00545	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H4W19_RS00550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4W19_RS00555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4W19_RS00580	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4W19_RS00585	COG3932	Exopolysaccharide synthesis, ExoD
H4W19_RS00605	COG1534	Rna-binding protein
H4W19_RS00610	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H4W19_RS00615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4W19_RS00620	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4W19_RS00625	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H4W19_RS00630	COG1923	regulation of RNA biosynthetic process
H4W19_RS00635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H4W19_RS00640	COG0330	HflC and HflK could
H4W19_RS00645	COG0330	HflC and HflK could
H4W19_RS00655	COG2852	Protein conserved in bacteria
H4W19_RS00685	COG0732	type I restriction modification DNA specificity domain
H4W19_RS00690	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
H4W19_RS00705	COG2202	Pas domain
H4W19_RS00705	COG3920	Histidine kinase
H4W19_RS00735	COG2205	protein histidine kinase activity
H4W19_RS00810	COG0753	catalase activity
H4W19_RS00825	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4W19_RS00825	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H4W19_RS00830	COG2814	Major facilitator Superfamily
H4W19_RS00840	COG1988	membrane-bound metal-dependent
H4W19_RS00860	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H4W19_RS00865	COG2894	cell division
H4W19_RS00870	COG0850	regulation of cytokinetic process
H4W19_RS00880	COG4585	Histidine kinase
H4W19_RS00885	COG2197	response regulator
H4W19_RS00900	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
H4W19_RS00955	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4W19_RS00970	COG1595	DNA-templated transcription, initiation
H4W19_RS00975	COG1595	DNA-templated transcription, initiation
H4W19_RS00985	COG1946	Acyl-CoA thioesterase
H4W19_RS01005	COG0116	Belongs to the methyltransferase superfamily
H4W19_RS01005	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4W19_RS01015	COG2201	protein-glutamate methylesterase activity
H4W19_RS01030	COG0686	Belongs to the AlaDH PNT family
H4W19_RS01035	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4W19_RS01040	COG1917	Cupin 2, conserved barrel domain protein
H4W19_RS01040	COG1396	sequence-specific DNA binding
H4W19_RS01045	COG1012	belongs to the aldehyde dehydrogenase family
H4W19_RS01050	COG0477	Major facilitator Superfamily
H4W19_RS01055	COG2703	oxygen carrier activity
H4W19_RS01065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W19_RS01070	COG0174	glutamine synthetase
H4W19_RS01090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
H4W19_RS01100	COG3842	ATPase activity
H4W19_RS01105	COG1176	ABC-type spermidine putrescine transport system, permease component I
H4W19_RS01110	COG1177	transmembrane transport
H4W19_RS01115	COG1012	belongs to the aldehyde dehydrogenase family
H4W19_RS01120	COG1741	Belongs to the pirin family
H4W19_RS01135	COG1741	Belongs to the pirin family
H4W19_RS01150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4W19_RS01160	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H4W19_RS01175	COG2354	Protein conserved in bacteria
H4W19_RS01180	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H4W19_RS01185	COG0745	RESPONSE REGULATOR receiver
H4W19_RS01190	COG2205	protein histidine kinase activity
H4W19_RS01195	COG4452	Inner membrane protein CreD
H4W19_RS01220	COG0671	phosphoesterase, PA-phosphatase related
H4W19_RS01225	COG0438	transferase activity, transferring glycosyl groups
H4W19_RS01230	COG0789	Transcriptional regulator
H4W19_RS01260	COG0393	Putative heavy-metal-binding
H4W19_RS01265	COG0662	Cupin 2, conserved barrel domain protein
H4W19_RS01270	COG4989	oxidoreductase activity
H4W19_RS01275	COG2199	diguanylate cyclase activity
H4W19_RS01275	COG2200	EAL domain
H4W19_RS01280	COG0248	Ppx GppA phosphatase
H4W19_RS01285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H4W19_RS01290	COG5002	protein histidine kinase activity
H4W19_RS01300	COG4783	chaperone-mediated protein folding
H4W19_RS01315	COG0473	3-isopropylmalate dehydrogenase activity
H4W19_RS01355	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4W19_RS01365	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4W19_RS01390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4W19_RS01415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4W19_RS01420	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4W19_RS01425	COG0631	protein serine/threonine phosphatase activity
H4W19_RS01440	COG0859	PFAM glycosyl transferase family 9
H4W19_RS01450	COG1234	tRNA 3'-trailer cleavage
H4W19_RS01460	COG0315	cyclic pyranopterin monophosphate synthase activity
H4W19_RS01470	COG0314	molybdopterin synthase activity
H4W19_RS01515	COG1401	restriction endodeoxyribonuclease activity
H4W19_RS01580	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4W19_RS01615	COG3621	Patatin-like phospholipase
H4W19_RS01625	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4W19_RS01645	COG2003	Belongs to the UPF0758 family
H4W19_RS01690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4W19_RS01700	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4W19_RS01705	COG0537	adenosine 5'-monophosphoramidase activity
H4W19_RS01725	COG0714	Associated with various cellular activities
H4W19_RS01740	COG1399	metal-binding, possibly nucleic acid-binding protein
H4W19_RS01745	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4W19_RS01750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W19_RS01755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4W19_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS01770	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W19_RS01775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4W19_RS01780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H4W19_RS01785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H4W19_RS01850	COG0346	lactoylglutathione lyase activity
H4W19_RS01885	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W19_RS01885	COG1024	Enoyl-CoA hydratase
H4W19_RS01900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4W19_RS01905	COG0481	GTPase activity
H4W19_RS01910	COG0681	Belongs to the peptidase S26 family
H4W19_RS01925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4W19_RS01930	COG1381	Involved in DNA repair and RecF pathway recombination
H4W19_RS01945	COG2954	triphosphatase activity
H4W19_RS01955	COG3046	protein related to deoxyribodipyrimidine photolyase
H4W19_RS01960	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W19_RS01965	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H4W19_RS01970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H4W19_RS01975	COG1278	Cold shock
H4W19_RS01980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W19_RS01985	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS02015	COG1132	(ABC) transporter
H4W19_RS02040	COG2304	oxidoreductase activity
H4W19_RS02065	COG4771	TonB-dependent receptor
H4W19_RS02085	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
H4W19_RS02095	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H4W19_RS02100	COG0671	phosphoesterase, PA-phosphatase related
H4W19_RS02130	COG0697	spore germination
H4W19_RS02135	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H4W19_RS02140	COG0167	dihydroorotate dehydrogenase activity
H4W19_RS02150	COG1012	belongs to the aldehyde dehydrogenase family
H4W19_RS02160	COG0527	aspartate kinase activity
H4W19_RS02160	COG0460	homoserine dehydrogenase
H4W19_RS02170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4W19_RS02200	COG0640	Transcriptional regulator
H4W19_RS02210	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4W19_RS02240	COG1609	Transcriptional regulator
H4W19_RS02255	COG0366	Alpha amylase catalytic
H4W19_RS02260	COG2819	hydrolase of the alpha beta superfamily
H4W19_RS02320	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS02325	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H4W19_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS02340	COG0501	Belongs to the peptidase M48B family
H4W19_RS02350	COG1509	lysine 2,3-aminomutase activity
H4W19_RS02365	COG0402	S-adenosylhomocysteine deaminase activity
H4W19_RS02370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H4W19_RS02385	COG1469	GTP cyclohydrolase I activity
H4W19_RS02395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4W19_RS02415	COG2166	iron-sulfur cluster assembly
H4W19_RS02430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4W19_RS02435	COG0137	argininosuccinate synthase activity
H4W19_RS02440	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W19_RS02445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4W19_RS02455	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H4W19_RS02460	COG0165	Argininosuccinate lyase
H4W19_RS02500	COG2986	histidine ammonia-lyase
H4W19_RS02515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H4W19_RS02520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H4W19_RS02525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4W19_RS02530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4W19_RS02530	COG0131	Imidazoleglycerol-phosphate dehydratase
H4W19_RS02535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H4W19_RS02550	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4W19_RS02550	COG0140	phosphoribosyl-ATP diphosphatase activity
H4W19_RS02570	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H4W19_RS02575	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
H4W19_RS02580	COG0235	Class ii aldolase
H4W19_RS02590	COG0531	amino acid
H4W19_RS02595	COG0531	amino acid
H4W19_RS02605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4W19_RS02610	COG0277	FAD linked oxidase domain protein
H4W19_RS02625	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4W19_RS02660	COG1024	Enoyl-CoA hydratase
H4W19_RS02690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H4W19_RS02705	COG0183	Belongs to the thiolase family
H4W19_RS02715	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS02735	COG1703	isobutyryl-CoA mutase activity
H4W19_RS02735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W19_RS02735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H4W19_RS02740	COG4680	protein conserved in bacteria
H4W19_RS02755	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4W19_RS02820	COG1619	proteins homologs of microcin C7 resistance protein MccF
H4W19_RS02870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4W19_RS02885	COG3590	peptidase
H4W19_RS02920	COG3706	GGDEF domain
H4W19_RS02930	COG0251	oxidation-reduction process
H4W19_RS02940	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W19_RS02960	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H4W19_RS02970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H4W19_RS02980	COG2081	HI0933 family
H4W19_RS02985	COG4681	YaeQ
H4W19_RS02990	COG1278	Cold shock
H4W19_RS02995	COG0513	Belongs to the DEAD box helicase family
H4W19_RS03015	COG0625	glutathione transferase activity
H4W19_RS03055	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4W19_RS03065	COG0604	alcohol dehydrogenase
H4W19_RS03090	COG0567	Dehydrogenase, E1 component
H4W19_RS03100	COG2850	peptidyl-arginine hydroxylation
H4W19_RS03150	COG1131	(ABC) transporter
H4W19_RS03155	COG1725	Transcriptional regulator
H4W19_RS03165	COG0386	Belongs to the glutathione peroxidase family
H4W19_RS03180	COG2900	Belongs to the SlyX family
H4W19_RS03195	COG2814	Major facilitator Superfamily
H4W19_RS03200	COG1410	methionine synthase
H4W19_RS03200	COG0646	methionine synthase
H4W19_RS03215	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS03225	COG0702	epimerase
H4W19_RS03230	COG1733	regulation of RNA biosynthetic process
H4W19_RS03235	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4W19_RS03245	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4W19_RS03250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS03260	COG2902	Dehydrogenase
H4W19_RS03265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H4W19_RS03295	COG2925	Exonuclease
H4W19_RS03300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W19_RS03330	COG0251	oxidation-reduction process
H4W19_RS03335	COG0288	reversible hydration of carbon dioxide
H4W19_RS03365	COG0017	Asparaginyl-tRNA synthetase
H4W19_RS03370	COG0316	Belongs to the HesB IscA family
H4W19_RS03380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4W19_RS03385	COG0359	binds to the 23S rRNA
H4W19_RS03390	COG0305	Participates in initiation and elongation during chromosome replication
H4W19_RS03395	COG3850	Histidine kinase
H4W19_RS03400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4W19_RS03405	COG0415	Belongs to the DNA photolyase family
H4W19_RS03425	COG2183	response to ionizing radiation
H4W19_RS03430	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
H4W19_RS03435	COG3876	Protein conserved in bacteria
H4W19_RS03445	COG2885	chlorophyll binding
H4W19_RS03475	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4W19_RS03485	COG2914	Belongs to the UPF0125 (RnfH) family
H4W19_RS03490	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W19_RS03500	COG0497	DNA recombination
H4W19_RS03505	COG1420	regulation of RNA biosynthetic process
H4W19_RS03510	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H4W19_RS03515	COG0443	Heat shock 70 kDa protein
H4W19_RS03520	COG0484	heat shock protein binding
H4W19_RS03530	COG2258	MOSC domain
H4W19_RS03535	COG4943	cyclic-guanylate-specific phosphodiesterase activity
H4W19_RS03545	COG0505	Belongs to the CarA family
H4W19_RS03550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4W19_RS03555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4W19_RS03600	COG2198	Histidine kinase
H4W19_RS03600	COG0784	Response regulator, receiver
H4W19_RS03600	COG2205	protein histidine kinase activity
H4W19_RS03605	COG1024	Enoyl-CoA hydratase
H4W19_RS03610	COG0318	PFAM AMP-dependent synthetase and ligase
H4W19_RS03625	COG1506	peptidase
H4W19_RS03650	COG2915	High frequency lysogenization protein hflD homolog
H4W19_RS03655	COG0482	sulfurtransferase activity
H4W19_RS03675	COG0542	response to heat
H4W19_RS03690	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4W19_RS03700	COG1408	metallophosphoesterase
H4W19_RS03705	COG0492	ferredoxin-NADP+ reductase activity
H4W19_RS03710	COG1674	ftsk spoiiie
H4W19_RS03720	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4W19_RS03725	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H4W19_RS03775	COG0243	molybdopterin cofactor binding
H4W19_RS03815	COG0583	DNA-binding transcription factor activity
H4W19_RS03865	COG0322	excinuclease ABC activity
H4W19_RS03880	COG0784	Response regulator, receiver
H4W19_RS03880	COG4191	Histidine kinase
H4W19_RS03905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4W19_RS03910	COG0826	peptidase U32
H4W19_RS03915	COG0826	peptidase U32
H4W19_RS03920	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
H4W19_RS03925	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
H4W19_RS03930	COG3154	lipid carrier protein
H4W19_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS03980	COG5001	Diguanylate cyclase
H4W19_RS03980	COG4251	negative regulation of phosphorylation
H4W19_RS03980	COG3706	GGDEF domain
H4W19_RS03980	COG2203	Gaf domain
H4W19_RS04045	COG0784	Response regulator, receiver
H4W19_RS04045	COG4191	Histidine kinase
H4W19_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS04090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4W19_RS04125	COG0784	Response regulator, receiver
H4W19_RS04140	COG0492	ferredoxin-NADP+ reductase activity
H4W19_RS04160	COG1376	ErfK ybiS ycfS ynhG family protein
H4W19_RS04165	COG0739	heme binding
H4W19_RS04175	COG2080	2 iron, 2 sulfur cluster binding
H4W19_RS04180	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H4W19_RS04185	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H4W19_RS04190	COG0745	RESPONSE REGULATOR receiver
H4W19_RS04195	COG2205	protein histidine kinase activity
H4W19_RS04195	COG4999	Histidine kinase
H4W19_RS04195	COG3850	Histidine kinase
H4W19_RS04195	COG3437	response regulator, receiver
H4W19_RS04200	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4W19_RS04210	COG2205	protein histidine kinase activity
H4W19_RS04210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4W19_RS04365	COG3328	transposase activity
H4W19_RS04395	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4W19_RS04480	COG0010	Belongs to the arginase family
H4W19_RS04485	COG2986	histidine ammonia-lyase
H4W19_RS04490	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
H4W19_RS04495	COG2188	Transcriptional regulator
H4W19_RS04515	COG2871	sodium ion transport
H4W19_RS04520	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4W19_RS04525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS04540	COG2217	Heavy metal translocating P-type atpase
H4W19_RS04545	COG2217	Heavy metal translocating P-type atpase
H4W19_RS04555	COG1063	alcohol dehydrogenase
H4W19_RS04585	COG0789	Transcriptional regulator
H4W19_RS04625	COG1725	Transcriptional regulator
H4W19_RS04630	COG1131	(ABC) transporter
H4W19_RS04650	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
H4W19_RS04695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W19_RS04700	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS04710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4W19_RS04740	COG2986	histidine ammonia-lyase
H4W19_RS04750	COG1216	Glycosyl transferase, family 2
H4W19_RS04765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4W19_RS04770	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4W19_RS04805	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H4W19_RS04815	COG0668	transmembrane transport
H4W19_RS04820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H4W19_RS04835	COG0519	Catalyzes the synthesis of GMP from XMP
H4W19_RS04835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4W19_RS04845	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4W19_RS04860	COG0475	glutathione-regulated potassium exporter activity
H4W19_RS04860	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4W19_RS04885	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H4W19_RS04890	COG0303	'Molybdopterin
H4W19_RS04895	COG1160	GTP binding
H4W19_RS04900	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W19_RS04910	COG1426	Protein conserved in bacteria
H4W19_RS04935	COG1024	Enoyl-CoA hydratase
H4W19_RS04935	COG1250	3-hydroxyacyl-CoA dehydrogenase
H4W19_RS04940	COG0183	Belongs to the thiolase family
H4W19_RS04945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W19_RS04950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4W19_RS04955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
H4W19_RS04970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H4W19_RS04980	COG0776	regulation of translation
H4W19_RS04990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H4W19_RS04995	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4W19_RS05005	COG2957	Belongs to the agmatine deiminase family
H4W19_RS05020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4W19_RS05045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS05065	COG0316	Belongs to the HesB IscA family
H4W19_RS05065	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
H4W19_RS05070	COG2154	pterin-4-alpha-carbinolamine dehydratase
H4W19_RS05085	COG1530	ribonuclease E activity
H4W19_RS05095	COG2234	aminopeptidase activity
H4W19_RS05125	COG1943	Transposase
H4W19_RS05155	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H4W19_RS05185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4W19_RS05190	COG0077	Prephenate dehydratase
H4W19_RS05190	COG1605	Chorismate mutase
H4W19_RS05195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4W19_RS05200	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4W19_RS05205	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H4W19_RS05240	COG2346	COG2346, Truncated hemoglobins
H4W19_RS05245	COG4221	oxidoreductase activity
H4W19_RS05280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4W19_RS05290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4W19_RS05295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4W19_RS05315	COG2197	response regulator
H4W19_RS05325	COG2201	protein-glutamate methylesterase activity
H4W19_RS05335	COG1677	Flagellar hook-basal body complex protein FliE
H4W19_RS05345	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4W19_RS05365	COG3144	bacterial-type flagellum assembly
H4W19_RS05445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4W19_RS05470	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
H4W19_RS05480	COG0784	Response regulator, receiver
H4W19_RS05480	COG0643	Histidine kinase
H4W19_RS05480	COG2198	Histidine kinase
H4W19_RS05485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4W19_RS05495	COG1192	Involved in chromosome partitioning
H4W19_RS05500	COG0835	chemotaxis
H4W19_RS05510	COG0745	RESPONSE REGULATOR receiver
H4W19_RS05515	COG2198	Histidine kinase
H4W19_RS05515	COG0643	Histidine kinase
H4W19_RS05520	COG3746	phosphate-selective porin O and P
H4W19_RS05525	COG0840	transmembrane signaling receptor activity
H4W19_RS05540	COG0840	transmembrane signaling receptor activity
H4W19_RS05545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
H4W19_RS05550	COG0840	transmembrane signaling receptor activity
H4W19_RS05555	COG0835	chemotaxis
H4W19_RS05560	COG0840	transmembrane signaling receptor activity
H4W19_RS05565	COG2200	EAL domain
H4W19_RS05565	COG2202	Pas domain
H4W19_RS05565	COG2199	diguanylate cyclase activity
H4W19_RS05575	COG0840	transmembrane signaling receptor activity
H4W19_RS05595	COG0840	transmembrane signaling receptor activity
H4W19_RS05610	COG2827	Endonuclease containing a URI domain
H4W19_RS05635	COG0835	chemotaxis
H4W19_RS05635	COG0784	Response regulator, receiver
H4W19_RS05640	COG1815	bacterial-type flagellum-dependent cell motility
H4W19_RS05645	COG1558	bacterial-type flagellum-dependent cell motility
H4W19_RS05650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4W19_RS05655	COG1749	Flagellar hook protein flgE
H4W19_RS05670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
H4W19_RS05680	COG1705	Flagellar rod assembly protein muramidase FlgJ
H4W19_RS05680	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4W19_RS05690	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4W19_RS05715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4W19_RS05745	COG1111	helicase
H4W19_RS05745	COG1205	dead DEAH box helicase
H4W19_RS05765	COG4191	Histidine kinase
H4W19_RS05775	COG4251	negative regulation of phosphorylation
H4W19_RS05780	COG3706	GGDEF domain
H4W19_RS05785	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H4W19_RS05795	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H4W19_RS05835	COG3115	cell septum assembly
H4W19_RS05865	COG0800	Aldolase
H4W19_RS05880	COG0395	ABC-type sugar transport system, permease component
H4W19_RS05885	COG1175	transmembrane transport
H4W19_RS05890	COG1653	transport
H4W19_RS05920	COG2350	Protein conserved in bacteria
H4W19_RS05925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
H4W19_RS05935	COG1187	pseudouridine synthase activity
H4W19_RS05940	COG0644	oxidoreductase
H4W19_RS05950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4W19_RS05965	COG0386	Belongs to the glutathione peroxidase family
H4W19_RS05970	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4W19_RS05975	COG0339	signal peptide processing
H4W19_RS05985	COG0071	Belongs to the small heat shock protein (HSP20) family
H4W19_RS05990	COG0678	peroxiredoxin activity
H4W19_RS05995	COG4953	penicillin-binding protein 1C
H4W19_RS06000	COG2373	Large extracellular alpha-helical protein
H4W19_RS06015	COG0069	glutamate synthase activity
H4W19_RS06060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4W19_RS06065	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H4W19_RS06070	COG1663	tetraacyldisaccharide 4'-kinase activity
H4W19_RS06080	COG0848	biopolymer transport protein
H4W19_RS06085	COG0811	peptide transport
H4W19_RS06090	COG2333	competence protein COMEC
H4W19_RS06090	COG0658	competence protein
H4W19_RS06135	COG1136	(ABC) transporter
H4W19_RS06140	COG4591	ABC-type transport system involved in lipoprotein release permease component
H4W19_RS06160	COG1053	succinate dehydrogenase
H4W19_RS06165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H4W19_RS06215	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS06230	COG0084	hydrolase, TatD family'
H4W19_RS06235	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H4W19_RS06265	COG1393	Belongs to the ArsC family
H4W19_RS06275	COG0625	glutathione transferase activity
H4W19_RS06285	COG1595	DNA-templated transcription, initiation
H4W19_RS06290	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
H4W19_RS06295	COG2860	membrane
H4W19_RS06300	COG3275	phosphorelay sensor kinase activity
H4W19_RS06320	COG1404	Belongs to the peptidase S8 family
H4W19_RS06330	COG2133	pyrroloquinoline quinone binding
H4W19_RS06345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4W19_RS06350	COG0436	Aminotransferase
H4W19_RS06360	COG4133	protoheme IX ABC transporter activity
H4W19_RS06395	COG3088	subunit of a heme lyase
H4W19_RS06405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4W19_RS06420	COG4974	Belongs to the 'phage' integrase family
H4W19_RS06435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4W19_RS06450	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4W19_RS06465	COG1794	racemase activity, acting on amino acids and derivatives
H4W19_RS06470	COG0251	oxidation-reduction process
H4W19_RS06485	COG2070	2-Nitropropane dioxygenase
H4W19_RS06540	COG0804	urea catabolic process
H4W19_RS06575	COG3243	poly(R)-hydroxyalkanoic acid synthase
H4W19_RS06585	COG1183	phosphatidylcholine synthase activity
H4W19_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS06605	COG1051	belongs to the nudix hydrolase family
H4W19_RS06610	COG2205	protein histidine kinase activity
H4W19_RS06625	COG2610	gluconate transmembrane transporter activity
H4W19_RS06665	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4W19_RS06675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
H4W19_RS06685	COG0195	Participates in both transcription termination and antitermination
H4W19_RS06690	COG0779	Required for maturation of 30S ribosomal subunits
H4W19_RS06700	COG1007	ATP synthesis coupled electron transport
H4W19_RS06740	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
H4W19_RS06745	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H4W19_RS06750	COG0649	NAD binding
H4W19_RS06755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W19_RS06760	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W19_RS06765	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4W19_RS06780	COG0149	triose-phosphate isomerase activity
H4W19_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS06795	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4W19_RS06800	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4W19_RS06805	COG0159	tryptophan synthase activity
H4W19_RS06810	COG0133	tryptophan synthase activity
H4W19_RS06825	COG0101	tRNA pseudouridine synthase activity
H4W19_RS06835	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4W19_RS06840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4W19_RS06845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4W19_RS06850	COG2890	protein-(glutamine-N5) methyltransferase activity
H4W19_RS06855	COG1999	signal sequence binding
H4W19_RS06875	COG0433	COG0433 Predicted ATPase
H4W19_RS06885	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4W19_RS06895	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4W19_RS06900	COG0412	Dienelactone hydrolase
H4W19_RS06910	COG0717	Belongs to the dCTP deaminase family
H4W19_RS06915	COG0489	protein tyrosine kinase activity
H4W19_RS06935	COG0457	Tetratricopeptide repeat
H4W19_RS06955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W19_RS06955	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W19_RS06960	COG2878	Part of a membrane complex involved in electron transport
H4W19_RS06990	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4W19_RS06990	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4W19_RS06995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4W19_RS07000	COG0166	Belongs to the GPI family
H4W19_RS07010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H4W19_RS07015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H4W19_RS07025	COG0617	tRNA 3'-terminal CCA addition
H4W19_RS07035	COG2197	response regulator
H4W19_RS07045	COG0655	NAD(P)H dehydrogenase (quinone) activity
H4W19_RS07050	COG1335	isochorismatase
H4W19_RS07065	COG2814	Major facilitator Superfamily
H4W19_RS07080	COG1741	Belongs to the pirin family
H4W19_RS07085	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H4W19_RS07095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4W19_RS07105	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4W19_RS07110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H4W19_RS07120	COG0351	phosphomethylpyrimidine kinase
H4W19_RS07130	COG3706	GGDEF domain
H4W19_RS07135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4W19_RS07140	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H4W19_RS07180	COG1215	transferase activity, transferring glycosyl groups
H4W19_RS07185	COG1442	glycosyl transferase family 8
H4W19_RS07185	COG1216	Glycosyl transferase, family 2
H4W19_RS07195	COG0726	polysaccharide deacetylase
H4W19_RS07200	COG0438	transferase activity, transferring glycosyl groups
H4W19_RS07220	COG0726	polysaccharide deacetylase
H4W19_RS07270	COG0438	transferase activity, transferring glycosyl groups
H4W19_RS07275	COG0367	asparagine synthase
H4W19_RS07285	COG2133	pyrroloquinoline quinone binding
H4W19_RS07300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4W19_RS07315	COG1215	transferase activity, transferring glycosyl groups
H4W19_RS07320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4W19_RS07340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H4W19_RS07345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H4W19_RS07350	COG2137	regulation of response to DNA damage stimulus
H4W19_RS07355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4W19_RS07360	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H4W19_RS07370	COG1546	Belongs to the CinA family
H4W19_RS07375	COG4771	TonB-dependent receptor
H4W19_RS07385	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
H4W19_RS07390	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
H4W19_RS07400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H4W19_RS07410	COG0335	large ribosomal subunit rRNA binding
H4W19_RS07415	COG0336	Belongs to the RNA methyltransferase TrmD family
H4W19_RS07420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H4W19_RS07435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4W19_RS07445	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4W19_RS07510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H4W19_RS07525	COG0196	riboflavin kinase activity
H4W19_RS07530	COG0728	peptidoglycan biosynthetic process
H4W19_RS07535	COG0268	Binds directly to 16S ribosomal RNA
H4W19_RS07540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H4W19_RS07545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4W19_RS07550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4W19_RS07555	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4W19_RS07560	COG0824	Thioesterase
H4W19_RS07570	COG1024	Enoyl-CoA hydratase
H4W19_RS07580	COG0494	nUDIX hydrolase
H4W19_RS07585	COG0545	Peptidyl-prolyl cis-trans isomerase
H4W19_RS07590	COG1024	Enoyl-CoA hydratase
H4W19_RS07600	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4W19_RS07615	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4W19_RS07620	COG0573	inorganic phosphate transmembrane transporter activity
H4W19_RS07630	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
H4W19_RS07635	COG0704	Plays a role in the regulation of phosphate uptake
H4W19_RS07645	COG3220	belongs to the UPF0276 family
H4W19_RS07655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H4W19_RS07660	COG5006	permease, DMT superfamily
H4W19_RS07665	COG1396	sequence-specific DNA binding
H4W19_RS07675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4W19_RS07685	COG0557	exoribonuclease II activity
H4W19_RS07695	COG3273	potassium ion transport
H4W19_RS07695	COG0471	metal ion transport
H4W19_RS07725	COG0367	asparagine synthase
H4W19_RS07730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H4W19_RS07735	COG1393	Belongs to the ArsC family
H4W19_RS07745	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
H4W19_RS07750	COG0024	Methionine aminopeptidase
H4W19_RS07795	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H4W19_RS07800	COG0575	Belongs to the CDS family
H4W19_RS07805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4W19_RS07810	COG0750	zinc metalloprotease
H4W19_RS07830	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4W19_RS07875	COG0037	tRNA processing
H4W19_RS07880	COG1722	exodeoxyribonuclease VII activity
H4W19_RS07885	COG0142	geranyltranstransferase activity
H4W19_RS07895	COG0312	modulator of DNA gyrase
H4W19_RS07905	COG0312	modulator of DNA gyrase
H4W19_RS07920	COG0424	maF-like protein
H4W19_RS07925	COG2968	Membrane
H4W19_RS07945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
H4W19_RS07960	COG0495	leucyl-tRNA aminoacylation
H4W19_RS07990	COG3118	belongs to the thioredoxin family
H4W19_RS08005	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H4W19_RS08010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W19_RS08020	COG2203	Gaf domain
H4W19_RS08020	COG3706	GGDEF domain
H4W19_RS08020	COG4251	negative regulation of phosphorylation
H4W19_RS08020	COG5001	Diguanylate cyclase
H4W19_RS08025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H4W19_RS08030	COG3590	peptidase
H4W19_RS08055	COG0306	phosphate transporter
H4W19_RS08065	COG1253	flavin adenine dinucleotide binding
H4W19_RS08075	COG3300	MHYT domain
H4W19_RS08075	COG5001	Diguanylate cyclase
H4W19_RS08095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W19_RS08100	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4W19_RS08105	COG1862	Preprotein translocase
H4W19_RS08130	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4W19_RS08145	COG4206	TonB-dependent receptor
H4W19_RS08155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H4W19_RS08165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4W19_RS08175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4W19_RS08180	COG0742	ribosomal rna small subunit methyltransferase
H4W19_RS08185	COG0326	Molecular chaperone. Has ATPase activity
H4W19_RS08195	COG0552	protein localization to endoplasmic reticulum
H4W19_RS08200	COG1194	a g-specific adenine glycosylase
H4W19_RS08205	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H4W19_RS08250	COG1472	Belongs to the glycosyl hydrolase 3 family
H4W19_RS08260	COG5520	Belongs to the glycosyl hydrolase 30 family
H4W19_RS08270	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS08280	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4W19_RS08310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4W19_RS08310	COG0072	phenylalanine-tRNA ligase activity
H4W19_RS08315	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4W19_RS08320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4W19_RS08330	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4W19_RS08335	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H4W19_RS08345	COG0556	nucleotide-excision repair
H4W19_RS08350	COG4969	Belongs to the N-Me-Phe pilin family
H4W19_RS08390	COG3275	phosphorelay sensor kinase activity
H4W19_RS08395	COG1611	Belongs to the LOG family
H4W19_RS08405	COG2095	MarC family integral membrane protein
H4W19_RS08410	COG0300	oxidoreductase activity
H4W19_RS08415	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4W19_RS08440	COG2835	tetraacyldisaccharide 4'-kinase activity
H4W19_RS08455	COG2969	positive regulation of protein catabolic process
H4W19_RS08460	COG0625	glutathione transferase activity
H4W19_RS08465	COG2857	Cytochrome c1
H4W19_RS08470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4W19_RS08475	COG0723	plastoquinol--plastocyanin reductase activity
H4W19_RS08480	COG0741	lytic transglycosylase activity
H4W19_RS08495	COG0842	Transport permease protein
H4W19_RS08500	COG1131	(ABC) transporter
H4W19_RS08510	COG1309	transcriptional regulator
H4W19_RS08520	COG1702	phosphate starvation-inducible protein PhoH
H4W19_RS08525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H4W19_RS08535	COG4535	Mg2 and Co2 transporter CorC
H4W19_RS08545	COG1082	Xylose isomerase domain protein TIM barrel
H4W19_RS08555	COG1966	Carbon starvation protein
H4W19_RS08560	COG2879	small protein
H4W19_RS08570	COG1506	peptidase
H4W19_RS08570	COG0823	Involved in the tonB-independent uptake of proteins
H4W19_RS08575	COG1297	OPT oligopeptide transporter protein
H4W19_RS08580	COG3104	oligopeptide transport
H4W19_RS08585	COG1506	peptidase
H4W19_RS08610	COG0629	single-stranded DNA binding
H4W19_RS08615	COG0142	geranyltranstransferase activity
H4W19_RS08640	COG0527	aspartate kinase activity
H4W19_RS08645	COG0384	phenazine biosynthesis protein PhzF
H4W19_RS08650	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H4W19_RS08665	COG1764	response to oxidative stress
H4W19_RS08670	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4W19_RS08685	COG0739	heme binding
H4W19_RS08725	COG1959	2 iron, 2 sulfur cluster binding
H4W19_RS08730	COG0719	Fe-S assembly protein
H4W19_RS08735	COG0396	ATPase activity
H4W19_RS08740	COG0719	Fe-S assembly protein
H4W19_RS08745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4W19_RS08750	COG0456	acetyltransferase
H4W19_RS08760	COG4774	siderophore transport
H4W19_RS08775	COG4771	TonB-dependent receptor
H4W19_RS08800	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4W19_RS08820	COG2261	transglycosylase associated protein
H4W19_RS08830	COG3178	'Phosphotransferase
H4W19_RS08835	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4W19_RS08840	COG1595	DNA-templated transcription, initiation
H4W19_RS08860	COG0628	permease
H4W19_RS08880	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4W19_RS08900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H4W19_RS08905	COG0271	Belongs to the BolA IbaG family
H4W19_RS08915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H4W19_RS08930	COG1137	ATPase activity
H4W19_RS08965	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H4W19_RS08970	COG2239	Acts as a magnesium transporter
H4W19_RS09000	COG0540	Belongs to the ATCase OTCase family
H4W19_RS09005	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H4W19_RS09015	COG0519	Catalyzes the synthesis of GMP from XMP
H4W19_RS09030	COG3655	Transcriptional regulator
H4W19_RS09035	COG1506	peptidase
H4W19_RS09055	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4W19_RS09100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H4W19_RS09115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H4W19_RS09145	COG3038	cytochrome b561
H4W19_RS09160	COG1760	l-serine dehydratase
H4W19_RS09175	COG0527	aspartate kinase activity
H4W19_RS09175	COG0460	homoserine dehydrogenase
H4W19_RS09180	COG0626	cystathionine gamma-synthase activity
H4W19_RS09185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H4W19_RS09195	COG0739	heme binding
H4W19_RS09200	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H4W19_RS09210	COG1272	protein, Hemolysin III
H4W19_RS09225	COG0463	Glycosyl transferase, family 2
H4W19_RS09240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H4W19_RS09250	COG0457	Tetratricopeptide repeat
H4W19_RS09290	COG0045	succinate-CoA ligase (ADP-forming) activity
H4W19_RS09320	COG0463	Glycosyl transferase, family 2
H4W19_RS09325	COG2226	methyltransferase
H4W19_RS09345	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H4W19_RS09365	COG0494	nUDIX hydrolase
H4W19_RS09375	COG0739	heme binding
H4W19_RS09385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4W19_RS09400	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H4W19_RS09405	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4W19_RS09410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4W19_RS09430	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H4W19_RS09445	COG3116	cell division
H4W19_RS09450	COG0275	rRNA processing
H4W19_RS09495	COG0792	nuclease activity
H4W19_RS09500	COG0277	FAD linked oxidase domain protein
H4W19_RS09515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4W19_RS09520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4W19_RS09540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4W19_RS09540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4W19_RS09550	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H4W19_RS09555	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4W19_RS09565	COG0488	(ABC) transporter
H4W19_RS09590	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4W19_RS09595	COG1970	mechanosensitive ion channel activity
H4W19_RS09605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4W19_RS09610	COG1115	amino acid carrier protein
H4W19_RS09620	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H4W19_RS09630	COG0529	Catalyzes the synthesis of activated sulfate
H4W19_RS09630	COG2895	sulfate adenylyltransferase (ATP) activity
H4W19_RS09635	COG0175	sulfate reduction
H4W19_RS09640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H4W19_RS09645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H4W19_RS09655	COG3275	phosphorelay sensor kinase activity
H4W19_RS09715	COG0346	lactoylglutathione lyase activity
H4W19_RS09730	COG1846	Transcriptional regulator
H4W19_RS09735	COG3588	fructose-bisphosphate aldolase
H4W19_RS09740	COG0469	pyruvate kinase activity
H4W19_RS09750	COG0126	phosphoglycerate kinase activity
H4W19_RS09765	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4W19_RS09770	COG3047	cAMP biosynthetic process
H4W19_RS09780	COG0725	ABC transporter, periplasmic molybdate-binding protein
H4W19_RS09785	COG4149	molybdate abc transporter
H4W19_RS09790	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4W19_RS09800	COG0427	acetyl-CoA hydrolase
H4W19_RS09805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4W19_RS09810	COG1301	dicarboxylic acid transport
H4W19_RS09840	COG0714	Associated with various cellular activities
H4W19_RS09870	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
H4W19_RS09885	COG1335	isochorismatase
H4W19_RS09890	COG0372	Belongs to the citrate synthase family
H4W19_RS09895	COG0254	rRNA binding
H4W19_RS09910	COG1395	domain, Protein
H4W19_RS09955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS09970	COG2194	sulfuric ester hydrolase activity
H4W19_RS09975	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4W19_RS09990	COG0463	Glycosyl transferase, family 2
H4W19_RS10010	COG0672	)-iron permease
H4W19_RS10025	COG2814	Major facilitator Superfamily
H4W19_RS10085	COG1238	metal cluster binding
H4W19_RS10090	COG0653	protein targeting
H4W19_RS10100	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4W19_RS10120	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4W19_RS10150	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4W19_RS10155	COG1758	RNA polymerase activity
H4W19_RS10165	COG1561	YicC-like family, N-terminal region
H4W19_RS10170	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H4W19_RS10175	COG0346	lactoylglutathione lyase activity
H4W19_RS10185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4W19_RS10200	COG0006	proline dipeptidase activity
H4W19_RS10235	COG0006	proline dipeptidase activity
H4W19_RS10265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H4W19_RS10295	COG2912	Transglutaminase-like superfamily
H4W19_RS10300	COG1773	rubredoxin
H4W19_RS10310	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H4W19_RS10325	COG0745	RESPONSE REGULATOR receiver
H4W19_RS10330	COG0642	Histidine kinase
H4W19_RS10335	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4W19_RS10340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W19_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS10370	COG0671	phosphoesterase, PA-phosphatase related
H4W19_RS10380	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H4W19_RS10385	COG0563	adenylate kinase activity
H4W19_RS10415	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H4W19_RS10460	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
H4W19_RS10465	COG3040	lipid binding
H4W19_RS10470	COG2823	Periplasmic or secreted lipoprotein
H4W19_RS10475	COG0673	inositol 2-dehydrogenase activity
H4W19_RS10495	COG0431	NADPH-dependent FMN reductase
H4W19_RS10500	COG1132	(ABC) transporter
H4W19_RS10525	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
H4W19_RS10535	COG1090	epimerase
H4W19_RS10560	COG4941	Belongs to the sigma-70 factor family
H4W19_RS10630	COG2814	Major facilitator Superfamily
H4W19_RS10780	COG0628	permease
H4W19_RS10790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4W19_RS10800	COG2197	response regulator
H4W19_RS10805	COG4585	Histidine kinase
H4W19_RS10815	COG1131	(ABC) transporter
H4W19_RS10820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS10825	COG1136	(ABC) transporter
H4W19_RS10830	COG0577	efflux transmembrane transporter activity
H4W19_RS10845	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
H4W19_RS10870	COG0697	spore germination
H4W19_RS10875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4W19_RS10875	COG2169	Transcriptional regulator
H4W19_RS10885	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
H4W19_RS10890	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
H4W19_RS10900	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
H4W19_RS10915	COG0515	serine threonine protein kinase
H4W19_RS10915	COG2815	serine threonine protein kinase
H4W19_RS10925	COG0459	protein refolding
H4W19_RS10930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4W19_RS10935	COG1324	tolerance protein
H4W19_RS10945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4W19_RS10950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H4W19_RS10955	COG0511	ligase activity, forming carbon-carbon bonds
H4W19_RS10960	COG0439	Biotin carboxylase
H4W19_RS10980	COG2264	protein methyltransferase activity
H4W19_RS10990	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H4W19_RS10995	COG0138	bifunctional purine biosynthesis protein purh
H4W19_RS11005	COG0151	Belongs to the GarS family
H4W19_RS11010	COG1902	pentaerythritol trinitrate reductase activity
H4W19_RS11015	COG2814	Major facilitator Superfamily
H4W19_RS11040	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
H4W19_RS11105	COG2801	Transposase and inactivated derivatives
H4W19_RS11120	COG1056	cytidyltransferase-related domain
H4W19_RS11120	COG1051	belongs to the nudix hydrolase family
H4W19_RS11130	COG3005	denitrification pathway
H4W19_RS11135	COG3043	anaerobic respiration
H4W19_RS11140	COG0243	molybdopterin cofactor binding
H4W19_RS11150	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4W19_RS11150	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4W19_RS11155	COG4459	periplasmic nitrate reductase
H4W19_RS11160	COG0746	molybdenum cofactor guanylyltransferase activity
H4W19_RS11165	COG0303	'Molybdopterin
H4W19_RS11225	COG4774	siderophore transport
H4W19_RS11245	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H4W19_RS11255	COG0642	Histidine kinase
H4W19_RS11270	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS11280	COG1022	Amp-dependent synthetase and ligase
H4W19_RS11295	COG0531	amino acid
H4W19_RS11300	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4W19_RS11310	COG0457	Tetratricopeptide repeat
H4W19_RS11315	COG4771	TonB-dependent receptor
H4W19_RS11325	COG1294	oxidase, subunit
H4W19_RS11330	COG1271	oxidase subunit
H4W19_RS11335	COG3278	Belongs to the heme-copper respiratory oxidase family
H4W19_RS11360	COG0348	domain, Protein
H4W19_RS11370	COG2217	Heavy metal translocating P-type atpase
H4W19_RS11385	COG4988	ABC transporter
H4W19_RS11390	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
H4W19_RS11395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H4W19_RS11400	COG0513	Belongs to the DEAD box helicase family
H4W19_RS11405	COG0720	synthase
H4W19_RS11415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4W19_RS11420	COG1956	GAF domain-containing protein
H4W19_RS11430	COG4206	TonB-dependent receptor
H4W19_RS11440	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H4W19_RS11445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4W19_RS11455	COG0584	glycerophosphoryl diester phosphodiesterase
H4W19_RS11495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W19_RS11505	COG1136	(ABC) transporter
H4W19_RS11515	COG0577	efflux transmembrane transporter activity
H4W19_RS11515	COG1136	(ABC) transporter
H4W19_RS11540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4W19_RS11550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4W19_RS11555	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4W19_RS11565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H4W19_RS11570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4W19_RS11575	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H4W19_RS11585	COG0356	it plays a direct role in the translocation of protons across the membrane
H4W19_RS11605	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H4W19_RS11610	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W19_RS11665	COG0697	spore germination
H4W19_RS11690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4W19_RS11695	COG1187	pseudouridine synthase activity
H4W19_RS11700	COG2813	Specifically methylates the guanine in position
H4W19_RS11715	COG1690	Belongs to the RtcB family
H4W19_RS11720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
H4W19_RS11725	COG4181	ATPase activity
H4W19_RS11745	COG1228	amidohydrolase
H4W19_RS11750	COG0667	Aldo Keto reductase
H4W19_RS11755	COG4221	oxidoreductase activity
H4W19_RS11760	COG2207	Transcriptional regulator
H4W19_RS11825	COG1858	cytochrome C peroxidase
H4W19_RS11830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
H4W19_RS11830	COG3264	Mechanosensitive ion channel
H4W19_RS11840	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H4W19_RS11855	COG3795	YCII-related domain
H4W19_RS11900	COG1446	asparaginase
H4W19_RS11935	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H4W19_RS11940	COG2201	protein-glutamate methylesterase activity
H4W19_RS11945	COG2177	Part of the ABC transporter FtsEX involved in
H4W19_RS11950	COG2884	Cell division ATP-binding protein ftsE
H4W19_RS11955	COG0513	Belongs to the DEAD box helicase family
H4W19_RS11960	COG3118	belongs to the thioredoxin family
H4W19_RS11965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4W19_RS11995	COG3100	YcgL domain-containing protein
H4W19_RS12010	COG0408	coproporphyrinogen oxidase activity
H4W19_RS12015	COG2323	membrane
H4W19_RS12035	COG0210	DNA helicase
H4W19_RS12045	COG0625	glutathione transferase activity
H4W19_RS12115	COG0714	Associated with various cellular activities
H4W19_RS12150	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H4W19_RS12160	COG0477	Major facilitator Superfamily
H4W19_RS12180	COG0357	Ribosomal RNA small subunit methyltransferase G
H4W19_RS12185	COG1192	Involved in chromosome partitioning
H4W19_RS12190	COG1475	DNA binding
H4W19_RS12200	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4W19_RS12210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4W19_RS12220	COG2205	protein histidine kinase activity
H4W19_RS12265	COG0477	Major facilitator Superfamily
H4W19_RS12280	COG1122	ATPase activity
H4W19_RS12285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H4W19_RS12295	COG0515	serine threonine protein kinase
H4W19_RS12295	COG2815	serine threonine protein kinase
H4W19_RS12310	COG0210	DNA helicase
H4W19_RS12330	COG3132	Protein of unknown function, DUF480
H4W19_RS12335	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
H4W19_RS12340	COG0284	orotidine-5'-phosphate decarboxylase activity
H4W19_RS12355	COG2937	Belongs to the GPAT DAPAT family
H4W19_RS12370	COG0037	tRNA processing
H4W19_RS12375	COG2974	May be involved in recombination
H4W19_RS12395	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H4W19_RS12410	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4W19_RS12430	COG0519	Catalyzes the synthesis of GMP from XMP
H4W19_RS12430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H4W19_RS12445	COG0729	surface antigen
H4W19_RS12480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4W19_RS12500	COG2267	carboxylic ester hydrolase activity
H4W19_RS12510	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4W19_RS12520	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
H4W19_RS12565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
H4W19_RS12570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4W19_RS12575	COG0270	DNA (cytosine-5-)-methyltransferase activity
H4W19_RS12595	COG0582	viral genome integration into host DNA
H4W19_RS12640	COG2826	transposase and inactivated derivatives, IS30 family
H4W19_RS12655	COG4771	TonB-dependent receptor
H4W19_RS12665	COG3485	protocatechuate 3,4-dioxygenase
H4W19_RS12690	COG2826	transposase and inactivated derivatives, IS30 family
H4W19_RS12695	COG2200	EAL domain
H4W19_RS12770	COG0515	serine threonine protein kinase
H4W19_RS12780	COG2885	chlorophyll binding
H4W19_RS12790	COG0515	serine threonine protein kinase
H4W19_RS12800	COG2885	chlorophyll binding
H4W19_RS12805	COG2188	Transcriptional regulator
H4W19_RS12810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H4W19_RS12815	COG0363	glucosamine-6-phosphate deaminase activity
H4W19_RS12855	COG0405	Gamma-glutamyltransferase
H4W19_RS12870	COG1396	sequence-specific DNA binding
H4W19_RS12875	COG3550	peptidyl-serine autophosphorylation
H4W19_RS12910	COG0714	Associated with various cellular activities
H4W19_RS12940	COG0070	glutamate synthase
H4W19_RS12940	COG0069	glutamate synthase activity
H4W19_RS12940	COG0067	glutamate synthase
H4W19_RS12945	COG0493	'glutamate synthase
H4W19_RS12955	COG3135	benzoate transporter
H4W19_RS12980	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4W19_RS12980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4W19_RS12985	COG1652	LysM domain
H4W19_RS13005	COG0583	DNA-binding transcription factor activity
H4W19_RS13010	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
H4W19_RS13020	COG2130	NADP-dependent
H4W19_RS13040	COG0753	catalase activity
H4W19_RS13045	COG3038	cytochrome b561
H4W19_RS13050	COG1187	pseudouridine synthase activity
H4W19_RS13060	COG1643	Atp-dependent helicase
H4W19_RS13065	COG0084	hydrolase, TatD family'
H4W19_RS13075	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
H4W19_RS13080	COG0842	Transport permease protein
H4W19_RS13085	COG1131	(ABC) transporter
H4W19_RS13100	COG4555	ABC transporter
H4W19_RS13105	COG1668	transmembrane transport
H4W19_RS13120	COG0706	membrane insertase activity
H4W19_RS13125	COG0594	ribonuclease P activity
H4W19_RS13140	COG0592	DNA-directed DNA polymerase activity
H4W19_RS13145	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H4W19_RS13150	COG0187	DNA topoisomerase II activity
H4W19_RS13160	COG0501	Belongs to the peptidase M48B family
H4W19_RS13205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4W19_RS13225	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4W19_RS13235	COG2197	response regulator
H4W19_RS13240	COG4585	Histidine kinase
H4W19_RS13270	COG3186	Phenylalanine-4-hydroxylase
H4W19_RS13275	COG1522	sequence-specific DNA binding
H4W19_RS13290	COG1752	Esterase of the alpha-beta hydrolase superfamily
H4W19_RS13310	COG0861	Integral membrane protein TerC family
H4W19_RS13315	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H4W19_RS13330	COG0531	amino acid
H4W19_RS13340	COG1322	Protein conserved in bacteria
H4W19_RS13345	COG2853	Lipoprotein
H4W19_RS13360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4W19_RS13365	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4W19_RS13370	COG1127	ABC transporter
H4W19_RS13375	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H4W19_RS13380	COG1074	ATP-dependent DNA helicase activity
H4W19_RS13385	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4W19_RS13415	COG3122	Protein conserved in bacteria
H4W19_RS13420	COG1451	nucleotide metabolic process
H4W19_RS13445	COG1335	isochorismatase
H4W19_RS13455	COG0302	gtp cyclohydrolase
H4W19_RS13465	COG1473	amidohydrolase
H4W19_RS13495	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H4W19_RS13505	COG1607	acyl-coa hydrolase
H4W19_RS13510	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4W19_RS13520	COG5383	Protein conserved in bacteria
H4W19_RS13560	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H4W19_RS13580	COG1285	pathogenesis
H4W19_RS13585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
H4W19_RS13590	COG2364	Membrane
H4W19_RS13595	COG0384	phenazine biosynthesis protein PhzF
H4W19_RS13615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4W19_RS13635	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H4W19_RS13660	COG1881	PFAM PEBP family protein
H4W19_RS13675	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
H4W19_RS13710	COG0174	glutamine synthetase
H4W19_RS13715	COG0347	Belongs to the P(II) protein family
H4W19_RS13720	COG0004	ammonium transporteR
H4W19_RS13730	COG2204	response regulator
H4W19_RS13735	COG2032	superoxide dismutase activity
H4W19_RS13745	COG0183	Belongs to the thiolase family
H4W19_RS13780	COG0456	acetyltransferase
H4W19_RS13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4W19_RS13795	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H4W19_RS13800	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H4W19_RS13825	COG1737	Transcriptional regulator
H4W19_RS13830	COG4948	Mandelate Racemase Muconate Lactonizing
H4W19_RS13850	COG3023	N-Acetylmuramoyl-L-alanine amidase
H4W19_RS13860	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
H4W19_RS13870	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4W19_RS13885	COG0612	Peptidase, M16
H4W19_RS13895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4W19_RS13900	COG0596	Alpha beta hydrolase
H4W19_RS13905	COG0727	PFAM Uncharacterised protein family (UPF0153)
H4W19_RS13910	COG0318	PFAM AMP-dependent synthetase and ligase
H4W19_RS13915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4W19_RS13940	COG0693	protein deglycase activity
H4W19_RS13955	COG0612	Peptidase, M16
H4W19_RS13960	COG0564	pseudouridine synthase activity
H4W19_RS13995	COG4942	peptidase
H4W19_RS14000	COG0793	Belongs to the peptidase S41A family
H4W19_RS14005	COG0475	glutathione-regulated potassium exporter activity
H4W19_RS14020	COG2067	long-chain fatty acid transport protein
H4W19_RS14030	COG3706	GGDEF domain
H4W19_RS14045	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H4W19_RS14045	COG1565	acr, cog1565
H4W19_RS14050	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H4W19_RS14055	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H4W19_RS14080	COG1612	heme a metabolic process
H4W19_RS14085	COG0109	protoheme IX farnesyltransferase activity
H4W19_RS14095	COG0358	DNA primase activity
H4W19_RS14100	COG0277	FAD linked oxidase domain protein
H4W19_RS14105	COG1295	ribonuclease BN
H4W19_RS14125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4W19_RS14130	COG0668	transmembrane transport
H4W19_RS14135	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H4W19_RS14140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4W19_RS14150	COG2308	Evidence 4 Homologs of previously reported genes of
H4W19_RS14180	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H4W19_RS14190	COG0837	glucose binding
H4W19_RS14200	COG1609	Transcriptional regulator
H4W19_RS14205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4W19_RS14210	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H4W19_RS14220	COG2133	pyrroloquinoline quinone binding
H4W19_RS14230	COG0463	Glycosyl transferase, family 2
H4W19_RS14235	COG2194	sulfuric ester hydrolase activity
H4W19_RS14250	COG0745	RESPONSE REGULATOR receiver
H4W19_RS14270	COG0617	tRNA 3'-terminal CCA addition
H4W19_RS14280	COG0730	response to heat
H4W19_RS14325	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
H4W19_RS14340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4W19_RS14350	COG0798	PFAM Bile acid sodium symporter
H4W19_RS14360	COG0431	NADPH-dependent FMN reductase
H4W19_RS14370	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H4W19_RS14395	COG1307	EDD domain protein, DegV family
H4W19_RS14400	COG3706	GGDEF domain
H4W19_RS14435	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H4W19_RS14450	COG0436	Aminotransferase
H4W19_RS14455	COG1162	GTPase activity
H4W19_RS14460	COG0786	glutamate:sodium symporter activity
H4W19_RS14470	COG0281	malic enzyme
H4W19_RS14470	COG0280	phosphate acetyltransferase
H4W19_RS14480	COG1366	Belongs to the anti-sigma-factor antagonist family
H4W19_RS14505	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H4W19_RS14510	COG3214	Protein conserved in bacteria
H4W19_RS14520	COG2409	Drug exporters of the RND superfamily
H4W19_RS14570	COG1012	belongs to the aldehyde dehydrogenase family
H4W19_RS14575	COG3284	Transcriptional regulator
H4W19_RS14585	COG0596	Alpha beta hydrolase
H4W19_RS14590	COG5001	Diguanylate cyclase
H4W19_RS14590	COG5002	protein histidine kinase activity
H4W19_RS14620	COG0583	DNA-binding transcription factor activity
H4W19_RS14625	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H4W19_RS14645	COG0606	chelatase, subunit chli
H4W19_RS14705	COG0653	protein targeting
H4W19_RS14760	COG0582	viral genome integration into host DNA
H4W19_RS14820	COG2390	Transcriptional regulator
H4W19_RS14820	COG4584	PFAM Integrase catalytic
H4W19_RS14825	COG1484	DNA-dependent DNA replication
H4W19_RS14830	COG2826	transposase and inactivated derivatives, IS30 family
H4W19_RS14845	COG3275	phosphorelay sensor kinase activity
H4W19_RS14925	COG1166	arginine decarboxylase activity
H4W19_RS14930	COG4221	oxidoreductase activity
H4W19_RS14945	COG0018	arginyl-trna synthetase
H4W19_RS14955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
H4W19_RS14965	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H4W19_RS14980	COG0708	Exodeoxyribonuclease III
H4W19_RS14985	COG2223	nitrite transmembrane transporter activity
H4W19_RS15000	COG0739	heme binding
H4W19_RS15085	COG1252	NADH dehydrogenase
H4W19_RS15090	COG0477	Major facilitator Superfamily
H4W19_RS15095	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4W19_RS15115	COG0534	Mate efflux family protein
H4W19_RS15120	COG0616	signal peptide processing
H4W19_RS15140	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS15165	COG1754	DNA topoisomerase type I activity
H4W19_RS15165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4W19_RS15170	COG1714	RDD family
H4W19_RS15175	COG1714	RDD family
H4W19_RS15190	COG0758	DNA mediated transformation
H4W19_RS15200	COG0242	peptide deformylase activity
H4W19_RS15205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H4W19_RS15210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H4W19_RS15210	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H4W19_RS15255	COG1560	Kdo2-lipid A biosynthetic process
H4W19_RS15260	COG1490	D-aminoacyl-tRNA deacylase activity
H4W19_RS15265	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4W19_RS15275	COG3275	phosphorelay sensor kinase activity
H4W19_RS15280	COG3279	Response regulator of the LytR AlgR family
H4W19_RS15300	COG2826	transposase and inactivated derivatives, IS30 family
H4W19_RS15310	COG1446	asparaginase
H4W19_RS15315	COG3142	Participates in the control of copper homeostasis
H4W19_RS15320	COG3537	Alpha-1,2-mannosidase
H4W19_RS15325	COG3250	beta-galactosidase activity
H4W19_RS15345	COG3537	Alpha-1,2-mannosidase
H4W19_RS15350	COG1609	Transcriptional regulator
H4W19_RS15355	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W19_RS15365	COG4772	TonB-dependent receptor
H4W19_RS15375	COG1609	Transcriptional regulator
H4W19_RS15380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
H4W19_RS15405	COG0181	hydroxymethylbilane synthase activity
H4W19_RS15435	COG1505	serine-type exopeptidase activity
H4W19_RS15455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H4W19_RS15470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H4W19_RS15475	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H4W19_RS15480	COG2824	Alkylphosphonate utilization operon protein PhnA
H4W19_RS15500	COG2226	methyltransferase
H4W19_RS15505	COG0308	aminopeptidase N
H4W19_RS15510	COG0596	Alpha beta hydrolase
H4W19_RS15510	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W19_RS15535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W19_RS15540	COG1077	Cell shape determining protein MreB Mrl
H4W19_RS15545	COG1792	Involved in formation and maintenance of cell shape
H4W19_RS15550	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
H4W19_RS15555	COG0768	penicillin binding
H4W19_RS15560	COG0772	Belongs to the SEDS family
H4W19_RS15565	COG2951	lytic endotransglycosylase activity
H4W19_RS15575	COG1686	Belongs to the peptidase S11 family
H4W19_RS15580	COG0697	spore germination
H4W19_RS15595	COG0321	lipoyl(octanoyl) transferase activity
H4W19_RS15600	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H4W19_RS15610	COG0778	Nitroreductase
H4W19_RS15615	COG2353	YceI-like domain
H4W19_RS15625	COG0297	glycogen (starch) synthase activity
H4W19_RS15635	COG1560	Kdo2-lipid A biosynthetic process
H4W19_RS15640	COG1560	Kdo2-lipid A biosynthetic process
H4W19_RS15645	COG1519	Transferase
H4W19_RS15650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W19_RS15655	COG1538	Outer membrane efflux protein
H4W19_RS15660	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4W19_RS15665	COG1309	transcriptional regulator
H4W19_RS15685	COG0473	3-isopropylmalate dehydrogenase activity
H4W19_RS15700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H4W19_RS15720	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H4W19_RS15725	COG0129	dihydroxy-acid dehydratase activity
H4W19_RS15735	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H4W19_RS15755	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4W19_RS15760	COG0741	lytic transglycosylase activity
H4W19_RS15775	COG0702	epimerase
H4W19_RS15810	COG2755	lipolytic protein G-D-S-L family
H4W19_RS15815	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS15820	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
H4W19_RS15825	COG1609	Transcriptional regulator
H4W19_RS15830	COG3507	Belongs to the glycosyl hydrolase 43 family
H4W19_RS15850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H4W19_RS15880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4W19_RS15885	COG0583	DNA-binding transcription factor activity
H4W19_RS15900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H4W19_RS15905	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H4W19_RS15915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
H4W19_RS15925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H4W19_RS15930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4W19_RS15945	COG2205	protein histidine kinase activity
H4W19_RS15950	COG0745	RESPONSE REGULATOR receiver
H4W19_RS15960	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4W19_RS15985	COG3228	Belongs to the MtfA family
H4W19_RS15995	COG1307	EDD domain protein, DegV family
H4W19_RS16000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4W19_RS16005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H4W19_RS16005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H4W19_RS16010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4W19_RS16040	COG3237	CsbD-like
H4W19_RS16050	COG0180	Tryptophanyl-tRNA synthetase
H4W19_RS16080	COG0508	dehydrogenase complex catalyzes the overall conversion of
H4W19_RS16095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
H4W19_RS16105	COG3483	tryptophan 2,3-dioxygenase activity
H4W19_RS16115	COG3104	oligopeptide transport
H4W19_RS16130	COG2852	Protein conserved in bacteria
H4W19_RS16135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H4W19_RS16150	COG0530	calcium, potassium:sodium antiporter activity
H4W19_RS16155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4W19_RS16155	COG2111	Na H antiporter
H4W19_RS16160	COG1006	Multisubunit Na H antiporter MnhC subunit
H4W19_RS16165	COG0651	ATP synthesis coupled electron transport
H4W19_RS16175	COG2212	antiporter activity
H4W19_RS16180	COG1320	monovalent cation:proton antiporter activity
H4W19_RS16195	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4W19_RS16200	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4W19_RS16205	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4W19_RS16210	COG1597	lipid kinase activity
H4W19_RS16240	COG2329	Antibiotic biosynthesis monooxygenase
H4W19_RS16245	COG0134	indole-3-glycerol-phosphate synthase activity
H4W19_RS16275	COG3736	Type IV secretory pathway, component VirB8
H4W19_RS16285	COG2948	multi-organism process
H4W19_RS16355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H4W19_RS16365	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H4W19_RS16375	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4W19_RS16395	COG0625	glutathione transferase activity
H4W19_RS16425	COG0626	cystathionine gamma-synthase activity
H4W19_RS16455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H4W19_RS16510	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4W19_RS16510	COG3218	ABC-type transport auxiliary lipoprotein component
H4W19_RS16515	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4W19_RS16520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4W19_RS16530	COG2966	Psort location CytoplasmicMembrane, score
H4W19_RS16540	COG0442	prolyl-tRNA aminoacylation
H4W19_RS16555	COG1183	phosphatidylcholine synthase activity
H4W19_RS16565	COG0456	acetyltransferase
H4W19_RS16580	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4W19_RS16590	COG0795	lipopolysaccharide-transporting ATPase activity
H4W19_RS16600	COG4974	Belongs to the 'phage' integrase family
H4W19_RS16610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4W19_RS16610	COG0047	phosphoribosylformylglycinamidine synthase activity
H4W19_RS16615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4W19_RS16625	COG5295	Hep Hag repeat protein
H4W19_RS16630	COG1404	Belongs to the peptidase S8 family
H4W19_RS16635	COG1459	type II secretion system
H4W19_RS16640	COG2165	general secretion pathway protein
H4W19_RS16645	COG4970	Tfp pilus assembly protein FimT
H4W19_RS16650	COG2165	general secretion pathway protein
H4W19_RS16655	COG4795	General secretion pathway protein
H4W19_RS16660	COG3156	type II secretion system protein K
H4W19_RS16665	COG3166	PFAM Fimbrial assembly family protein
H4W19_RS16680	COG1450	Type ii and iii secretion system protein
H4W19_RS16705	COG0471	metal ion transport
H4W19_RS16705	COG3273	potassium ion transport
H4W19_RS16715	COG2022	thiamine diphosphate biosynthetic process
H4W19_RS16745	COG0745	RESPONSE REGULATOR receiver
H4W19_RS16750	COG0642	Histidine kinase
H4W19_RS16760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4W19_RS16765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
H4W19_RS16775	COG0488	(ABC) transporter
H4W19_RS16780	COG4589	Belongs to the CDS family
H4W19_RS16795	COG1607	acyl-coa hydrolase
H4W19_RS16825	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4W19_RS16845	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H4W19_RS16850	COG2119	membrane
H4W19_RS16855	COG0667	Aldo Keto reductase
H4W19_RS16895	COG0330	HflC and HflK could
H4W19_RS16915	COG0509	glycine decarboxylation via glycine cleavage system
H4W19_RS16955	COG1960	acyl-CoA dehydrogenase activity
H4W19_RS16990	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H4W19_RS16995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4W19_RS16995	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H4W19_RS17000	COG4243	Vitamin k epoxide reductase
H4W19_RS17005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4W19_RS17010	COG0564	pseudouridine synthase activity
H4W19_RS17025	COG3011	Protein conserved in bacteria
H4W19_RS17045	COG0542	response to heat
H4W19_RS17050	COG5001	Diguanylate cyclase
H4W19_RS17050	COG5002	protein histidine kinase activity
H4W19_RS17055	COG5001	Diguanylate cyclase
H4W19_RS17055	COG5002	protein histidine kinase activity
H4W19_RS17060	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4W19_RS17060	COG4651	solute:proton antiporter activity
H4W19_RS17065	COG4206	TonB-dependent receptor
H4W19_RS17070	COG0488	(ABC) transporter
H4W19_RS17090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4W19_RS17105	COG3328	transposase activity
H4W19_RS17115	COG1764	response to oxidative stress
H4W19_RS17130	COG0217	transcriptional regulatory protein
H4W19_RS17135	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4W19_RS17140	COG0632	four-way junction helicase activity
H4W19_RS17150	COG2255	four-way junction helicase activity
H4W19_RS17155	COG0824	Thioesterase
H4W19_RS17160	COG0811	peptide transport
H4W19_RS17165	COG0848	biopolymer transport protein
H4W19_RS17180	COG2885	chlorophyll binding
H4W19_RS17190	COG0602	queuosine metabolic process
H4W19_RS17195	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4W19_RS17210	COG0339	signal peptide processing
H4W19_RS17220	COG2223	nitrite transmembrane transporter activity
H4W19_RS17230	COG0514	ATP-dependent DNA helicase (RecQ)
H4W19_RS17235	COG0783	Belongs to the Dps family
H4W19_RS17240	COG1643	Atp-dependent helicase
H4W19_RS17250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4W19_RS17270	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H4W19_RS17280	COG1199	ATP-dependent helicase activity
H4W19_RS17285	COG1214	PFAM Peptidase M22, glycoprotease
H4W19_RS17295	COG0189	ligase activity
H4W19_RS17305	COG0835	chemotaxis
H4W19_RS17310	COG0840	transmembrane signaling receptor activity
H4W19_RS17320	COG2201	protein-glutamate methylesterase activity
H4W19_RS17330	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4W19_RS17340	COG0494	nUDIX hydrolase
H4W19_RS17345	COG1218	3'(2'),5'-bisphosphate nucleotidase
H4W19_RS17350	COG3956	TIGRFAM MazG family protein
H4W19_RS17375	COG0642	Histidine kinase
H4W19_RS17380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4W19_RS17385	COG0577	efflux transmembrane transporter activity
H4W19_RS17385	COG1136	(ABC) transporter
H4W19_RS17390	COG1136	(ABC) transporter
H4W19_RS17390	COG0577	efflux transmembrane transporter activity
H4W19_RS17410	COG1404	Belongs to the peptidase S8 family
H4W19_RS17420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4W19_RS17425	COG0861	Integral membrane protein TerC family
H4W19_RS17445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H4W19_RS17460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H4W19_RS17465	COG2967	ApaG domain
H4W19_RS17475	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H4W19_RS17490	COG0123	including yeast histone deacetylase and acetoin utilization protein
H4W19_RS17495	COG2096	Adenosyltransferase
H4W19_RS17505	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W19_RS17510	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H4W19_RS17580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
H4W19_RS17585	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H4W19_RS17590	COG0583	DNA-binding transcription factor activity
H4W19_RS17595	COG3634	alkyl hydroperoxide reductase activity
H4W19_RS17675	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H4W19_RS17690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H4W19_RS17705	COG1404	Belongs to the peptidase S8 family
H4W19_RS17725	COG3706	GGDEF domain
H4W19_RS17740	COG1028	Short-chain dehydrogenase reductase Sdr
H4W19_RS17780	COG1295	ribonuclease BN
H4W19_RS17785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H4W19_RS17790	COG1254	Belongs to the acylphosphatase family
H4W19_RS17810	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4W19_RS17815	COG0456	acetyltransferase
H4W19_RS17820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4W19_RS17840	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H4W19_RS17850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4W19_RS17860	COG0193	aminoacyl-tRNA hydrolase activity
H4W19_RS17865	COG0012	GTP binding
H4W19_RS17885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4W19_RS17895	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4W19_RS17900	COG0250	Participates in transcription elongation, termination and antitermination
H4W19_RS17905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4W19_RS17915	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4W19_RS17920	COG0222	ribosome binding
H4W19_RS17925	COG0085	RNA polymerase activity
H4W19_RS17930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H4W19_RS17940	COG0049	tRNA binding
H4W19_RS17945	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H4W19_RS17950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4W19_RS17955	COG0051	transcription antitermination factor activity, RNA binding
H4W19_RS17960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4W19_RS17970	COG0089	rRNA binding
H4W19_RS17975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4W19_RS17980	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4W19_RS17985	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4W19_RS17990	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4W19_RS17995	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4W19_RS18000	COG0255	Belongs to the universal ribosomal protein uL29 family
H4W19_RS18005	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4W19_RS18015	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4W19_RS18020	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4W19_RS18025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4W19_RS18035	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4W19_RS18040	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4W19_RS18050	COG1841	ribosomal large subunit assembly
H4W19_RS18060	COG0201	protein transport
H4W19_RS18065	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
H4W19_RS18075	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H4W19_RS18090	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4W19_RS18095	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4W19_RS18105	COG0154	amidase activity
H4W19_RS18115	COG1217	gtp-binding protein TYPA
H4W19_RS18120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4W19_RS18130	COG0039	L-malate dehydrogenase activity
H4W19_RS18135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4W19_RS18145	COG0372	Belongs to the citrate synthase family
H4W19_RS18165	COG0625	glutathione transferase activity
H4W19_RS18175	COG0446	pyridine nucleotide-disulphide oxidoreductase
H4W19_RS18175	COG1902	pentaerythritol trinitrate reductase activity
H4W19_RS18195	COG0604	alcohol dehydrogenase
H4W19_RS18200	COG0667	Aldo Keto reductase
H4W19_RS18205	COG2814	Major facilitator Superfamily
H4W19_RS18210	COG0583	DNA-binding transcription factor activity
H4W19_RS18215	COG3384	dioxygenase
H4W19_RS18220	COG3047	cAMP biosynthetic process
H4W19_RS18220	COG2885	chlorophyll binding
H4W19_RS18230	COG1187	pseudouridine synthase activity
H4W19_RS18240	COG0156	8-amino-7-oxononanoate synthase activity
H4W19_RS18250	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H4W19_RS18255	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
H4W19_RS18260	COG4208	sulfate ABC transporter
H4W19_RS18265	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H4W19_RS18280	COG1063	alcohol dehydrogenase
H4W19_RS18290	COG0588	phosphoglycerate mutase activity
H4W19_RS18295	COG0285	dihydrofolate synthase activity
H4W19_RS18315	COG2833	Protein of unknown function (DUF455)
H4W19_RS18320	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4W19_RS18330	COG0735	belongs to the Fur family
H4W19_RS18360	COG1228	amidohydrolase