locus-tag	class	description
AOT82_RS00105	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
AOT82_RS00135	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT82_RS00135	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT82_RS00140	COG2610	gluconate transmembrane transporter activity
AOT82_RS00155	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS00160	COG0489	protein tyrosine kinase activity
AOT82_RS00175	COG0717	Belongs to the dCTP deaminase family
AOT82_RS00180	COG2969	positive regulation of protein catabolic process
AOT82_RS00185	COG0625	glutathione transferase activity
AOT82_RS00190	COG2857	Cytochrome c1
AOT82_RS00195	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AOT82_RS00200	COG0723	plastoquinol--plastocyanin reductase activity
AOT82_RS00205	COG0488	(ABC) transporter
AOT82_RS00235	COG2801	Transposase and inactivated derivatives
AOT82_RS00240	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT82_RS00245	COG0583	DNA-binding transcription factor activity
AOT82_RS00250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AOT82_RS00255	COG0066	3-isopropylmalate dehydratase activity
AOT82_RS00265	COG0473	3-isopropylmalate dehydrogenase activity
AOT82_RS00275	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AOT82_RS00300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AOT82_RS00305	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT82_RS00330	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AOT82_RS00335	COG0084	hydrolase, TatD family'
AOT82_RS00380	COG0012	GTP binding
AOT82_RS00390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT82_RS00395	COG0251	oxidation-reduction process
AOT82_RS00405	COG0583	DNA-binding transcription factor activity
AOT82_RS00410	COG1929	Belongs to the glycerate kinase type-1 family
AOT82_RS00425	COG0359	binds to the 23S rRNA
AOT82_RS00430	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AOT82_RS00435	COG0360	Binds together with S18 to 16S ribosomal RNA
AOT82_RS00450	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AOT82_RS00455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT82_RS00485	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AOT82_RS00535	COG0508	dehydrogenase complex catalyzes the overall conversion of
AOT82_RS00540	COG3047	cAMP biosynthetic process
AOT82_RS00545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT82_RS00560	COG1067	ATP-dependent peptidase activity
AOT82_RS00565	COG0357	Ribosomal RNA small subunit methyltransferase G
AOT82_RS00570	COG1192	Involved in chromosome partitioning
AOT82_RS00575	COG1475	DNA binding
AOT82_RS00580	COG0811	peptide transport
AOT82_RS00590	COG1132	(ABC) transporter
AOT82_RS00595	COG1663	tetraacyldisaccharide 4'-kinase activity
AOT82_RS00600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AOT82_RS00620	COG0183	Belongs to the thiolase family
AOT82_RS00625	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS00640	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
AOT82_RS00650	COG0129	dihydroxy-acid dehydratase activity
AOT82_RS00660	COG0537	adenosine 5'-monophosphoramidase activity
AOT82_RS00665	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT82_RS00680	COG4221	oxidoreductase activity
AOT82_RS00700	COG0321	lipoyl(octanoyl) transferase activity
AOT82_RS00710	COG4176	ABC-type proline glycine betaine transport system permease component
AOT82_RS00715	COG4175	Glycine betaine
AOT82_RS00735	COG1570	exodeoxyribonuclease VII activity
AOT82_RS00750	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AOT82_RS00760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AOT82_RS00785	COG0167	dihydroorotate dehydrogenase activity
AOT82_RS00810	COG0534	Mate efflux family protein
AOT82_RS00815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AOT82_RS00825	COG1862	Preprotein translocase
AOT82_RS00840	COG0741	lytic transglycosylase activity
AOT82_RS00840	COG1388	LysM domain
AOT82_RS00840	COG0741	lytic transglycosylase activity
AOT82_RS00840	COG1388	LysM domain
AOT82_RS00845	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AOT82_RS00850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AOT82_RS00860	COG0633	Ferredoxin
AOT82_RS00865	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT82_RS00875	COG2026	Addiction module toxin, RelE StbE family
AOT82_RS00890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AOT82_RS00900	COG3781	membrane
AOT82_RS00935	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AOT82_RS00940	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOT82_RS00950	COG0402	S-adenosylhomocysteine deaminase activity
AOT82_RS00955	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AOT82_RS00960	COG4266	Belongs to the allantoicase family
AOT82_RS00990	COG2233	PERMEase
AOT82_RS00995	COG0823	Involved in the tonB-independent uptake of proteins
AOT82_RS01015	COG2252	PERMEase
AOT82_RS01030	COG2850	peptidyl-arginine hydroxylation
AOT82_RS01045	COG0482	sulfurtransferase activity
AOT82_RS01050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AOT82_RS01055	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AOT82_RS01065	COG0445	tRNA wobble uridine modification
AOT82_RS01075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AOT82_RS01085	COG0583	DNA-binding transcription factor activity
AOT82_RS01090	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AOT82_RS01095	COG2807	transmembrane transport
AOT82_RS01100	COG2890	protein-(glutamine-N5) methyltransferase activity
AOT82_RS01120	COG1522	sequence-specific DNA binding
AOT82_RS01125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AOT82_RS01135	COG0439	Biotin carboxylase
AOT82_RS01140	COG0511	ligase activity, forming carbon-carbon bonds
AOT82_RS01145	COG0534	Mate efflux family protein
AOT82_RS01155	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AOT82_RS01160	COG5510	response to toxic substance
AOT82_RS01165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AOT82_RS01190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AOT82_RS01210	COG0438	transferase activity, transferring glycosyl groups
AOT82_RS01240	COG0438	transferase activity, transferring glycosyl groups
AOT82_RS01260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AOT82_RS01265	COG0616	signal peptide processing
AOT82_RS01300	COG0390	transport system, permease component
AOT82_RS01305	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOT82_RS01310	COG0824	Thioesterase
AOT82_RS01315	COG0708	Exodeoxyribonuclease III
AOT82_RS01320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AOT82_RS01330	COG1760	l-serine dehydratase
AOT82_RS01335	COG2233	PERMEase
AOT82_RS01355	COG1773	rubredoxin
AOT82_RS01360	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AOT82_RS01370	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AOT82_RS01375	COG0077	Prephenate dehydratase
AOT82_RS01375	COG1605	Chorismate mutase
AOT82_RS01380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOT82_RS01385	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AOT82_RS01405	COG1045	serine acetyltransferase
AOT82_RS01425	COG0405	Gamma-glutamyltransferase
AOT82_RS01445	COG0745	RESPONSE REGULATOR receiver
AOT82_RS01450	COG2205	protein histidine kinase activity
AOT82_RS01485	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOT82_RS01490	COG1448	Aminotransferase
AOT82_RS01495	COG0583	DNA-binding transcription factor activity
AOT82_RS01510	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOT82_RS01515	COG1757	Na H antiporter
AOT82_RS01520	COG2375	cellular response to nickel ion
AOT82_RS01525	COG4774	siderophore transport
AOT82_RS01530	COG4615	Cyclic peptide transporter
AOT82_RS01560	COG4221	oxidoreductase activity
AOT82_RS01570	COG1022	Amp-dependent synthetase and ligase
AOT82_RS01590	COG1902	pentaerythritol trinitrate reductase activity
AOT82_RS01600	COG2814	Major facilitator Superfamily
AOT82_RS01605	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS01610	COG1024	Enoyl-CoA hydratase
AOT82_RS01615	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT82_RS01620	COG0183	Belongs to the thiolase family
AOT82_RS01625	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS01640	COG0583	DNA-binding transcription factor activity
AOT82_RS01650	COG0671	phosphoesterase, PA-phosphatase related
AOT82_RS01660	COG3384	dioxygenase
AOT82_RS01665	COG2866	Carboxypeptidase
AOT82_RS01675	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS01710	COG5002	protein histidine kinase activity
AOT82_RS01735	COG2132	Multicopper oxidase
AOT82_RS01775	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AOT82_RS01780	COG1074	ATP-dependent DNA helicase activity
AOT82_RS01785	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT82_RS01790	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AOT82_RS01800	COG1966	Carbon starvation protein
AOT82_RS01810	COG0003	Pfam Anion-transporting ATPase
AOT82_RS01835	COG2079	MmgE PrpD family protein
AOT82_RS01840	COG2153	protein acetylation
AOT82_RS01855	COG1132	(ABC) transporter
AOT82_RS01860	COG2828	Protein conserved in bacteria
AOT82_RS01865	COG4115	mRNA cleavage
AOT82_RS01870	COG2161	toxin-antitoxin pair type II binding
AOT82_RS01875	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOT82_RS01885	COG0372	Belongs to the citrate synthase family
AOT82_RS01890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
AOT82_RS01900	COG0583	DNA-binding transcription factor activity
AOT82_RS01910	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AOT82_RS01915	COG0582	viral genome integration into host DNA
AOT82_RS01925	COG0697	spore germination
AOT82_RS01930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AOT82_RS01955	COG3228	Belongs to the MtfA family
AOT82_RS01970	COG0513	Belongs to the DEAD box helicase family
AOT82_RS01980	COG0625	glutathione transferase activity
AOT82_RS01985	COG0477	Major facilitator Superfamily
AOT82_RS02005	COG0640	Transcriptional regulator
AOT82_RS02015	COG4208	sulfate ABC transporter
AOT82_RS02025	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOT82_RS02030	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AOT82_RS02040	COG2046	Belongs to the sulfate adenylyltransferase family
AOT82_RS02045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT82_RS02060	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS02065	COG1648	precorrin-2 dehydrogenase activity
AOT82_RS02065	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOT82_RS02070	COG0420	3'-5' exonuclease activity
AOT82_RS02075	COG0419	ATPase involved in DNA repair
AOT82_RS02090	COG0151	Belongs to the GarS family
AOT82_RS02095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT82_RS02100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOT82_RS02105	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AOT82_RS02110	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AOT82_RS02120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AOT82_RS02125	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AOT82_RS02140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AOT82_RS02160	COG2323	membrane
AOT82_RS02180	COG1643	Atp-dependent helicase
AOT82_RS02200	COG0471	metal ion transport
AOT82_RS02215	COG0302	gtp cyclohydrolase
AOT82_RS02220	COG1454	alcohol dehydrogenase
AOT82_RS02225	COG4172	Belongs to the ABC transporter superfamily
AOT82_RS02230	COG4239	(ABC) transporter, permease
AOT82_RS02235	COG4174	ABC transporter (Permease)
AOT82_RS02240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AOT82_RS02245	COG4166	transmembrane transport
AOT82_RS02250	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AOT82_RS02260	COG0501	Belongs to the peptidase M48B family
AOT82_RS02265	COG1704	LemA family
AOT82_RS02295	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AOT82_RS02300	COG0134	indole-3-glycerol-phosphate synthase activity
AOT82_RS02310	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
AOT82_RS02315	COG0668	transmembrane transport
AOT82_RS02320	COG4206	TonB-dependent receptor
AOT82_RS02325	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AOT82_RS02330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AOT82_RS02335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT82_RS02340	COG5001	Diguanylate cyclase
AOT82_RS02340	COG3300	MHYT domain
AOT82_RS02345	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS02350	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS02365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AOT82_RS02370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AOT82_RS02385	COG4232	protein-disulfide reductase activity
AOT82_RS02395	COG3676	manually curated
AOT82_RS02410	COG3676	manually curated
AOT82_RS02415	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AOT82_RS02450	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AOT82_RS02455	COG0305	Participates in initiation and elongation during chromosome replication
AOT82_RS02460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AOT82_RS02465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AOT82_RS02480	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AOT82_RS02485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AOT82_RS02490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AOT82_RS02510	COG0513	Belongs to the DEAD box helicase family
AOT82_RS02525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT82_RS02530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT82_RS02535	COG0217	transcriptional regulatory protein
AOT82_RS02545	COG0552	protein localization to endoplasmic reticulum
AOT82_RS02550	COG0612	Peptidase, M16
AOT82_RS02570	COG0772	Belongs to the SEDS family
AOT82_RS02585	COG1137	ATPase activity
AOT82_RS02590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AOT82_RS02600	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AOT82_RS02610	COG1923	regulation of RNA biosynthetic process
AOT82_RS02615	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AOT82_RS02620	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AOT82_RS02625	COG0802	atpase or kinase
AOT82_RS02635	COG1742	UPF0060 membrane protein
AOT82_RS02645	COG0501	Belongs to the peptidase M48B family
AOT82_RS02650	COG0653	protein targeting
AOT82_RS02660	COG0019	diaminopimelate decarboxylase activity
AOT82_RS02675	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AOT82_RS02680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT82_RS02685	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AOT82_RS02690	COG0308	aminopeptidase N
AOT82_RS02700	COG2885	chlorophyll binding
AOT82_RS02715	COG1414	Transcriptional regulator
AOT82_RS02725	COG1024	Enoyl-CoA hydratase
AOT82_RS02730	COG1024	Enoyl-CoA hydratase
AOT82_RS02745	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT82_RS02750	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS02770	COG0415	Belongs to the DNA photolyase family
AOT82_RS02785	COG1309	transcriptional regulator
AOT82_RS02790	COG1979	alcohol dehydrogenase
AOT82_RS02795	COG2130	NADP-dependent
AOT82_RS02820	COG0259	pyridoxamine-phosphate oxidase activity
AOT82_RS02825	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AOT82_RS02840	COG0215	cysteine-tRNA ligase activity
AOT82_RS02845	COG2096	Adenosyltransferase
AOT82_RS02865	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AOT82_RS02880	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS02940	COG2963	transposase activity
AOT82_RS02975	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS02980	COG2015	COG2015, Alkyl sulfatase and related hydrolases
AOT82_RS03015	COG1002	Type II restriction enzyme, methylase subunits
AOT82_RS03020	COG1061	Type III restriction enzyme res subunit
AOT82_RS03025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AOT82_RS03105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT82_RS03110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT82_RS03115	COG2217	Heavy metal translocating P-type atpase
AOT82_RS03130	COG0531	amino acid
AOT82_RS03145	COG2132	Multicopper oxidase
AOT82_RS03170	COG0745	RESPONSE REGULATOR receiver
AOT82_RS03175	COG5002	protein histidine kinase activity
AOT82_RS03185	COG0583	DNA-binding transcription factor activity
AOT82_RS03200	COG3676	manually curated
AOT82_RS03230	COG0281	malic enzyme
AOT82_RS03235	COG1971	Probably functions as a manganese efflux pump
AOT82_RS03245	COG2814	Major facilitator Superfamily
AOT82_RS03250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT82_RS03255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AOT82_RS03260	COG1120	ATPase activity
AOT82_RS03275	COG0625	glutathione transferase activity
AOT82_RS03280	COG0204	Acyl-transferase
AOT82_RS03290	COG0589	response to stress
AOT82_RS03295	COG3122	Protein conserved in bacteria
AOT82_RS03330	COG3961	Belongs to the TPP enzyme family
AOT82_RS03355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOT82_RS03360	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT82_RS03360	COG1024	Enoyl-CoA hydratase
AOT82_RS03365	COG0183	Belongs to the thiolase family
AOT82_RS03370	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS03380	COG2801	Transposase and inactivated derivatives
AOT82_RS03415	COG2301	Belongs to the HpcH HpaI aldolase family
AOT82_RS03420	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS03430	COG2130	NADP-dependent
AOT82_RS03435	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS03440	COG1917	Cupin 2, conserved barrel domain protein
AOT82_RS03440	COG2169	Transcriptional regulator
AOT82_RS03445	COG1619	proteins homologs of microcin C7 resistance protein MccF
AOT82_RS03450	COG3339	Conserved Protein
AOT82_RS03465	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AOT82_RS03490	COG2878	Part of a membrane complex involved in electron transport
AOT82_RS03495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AOT82_RS03500	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AOT82_RS03520	COG2801	Transposase and inactivated derivatives
AOT82_RS03540	COG2133	pyrroloquinoline quinone binding
AOT82_RS03560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT82_RS03570	COG3123	guanosine phosphorylase activity
AOT82_RS03595	COG0505	Belongs to the CarA family
AOT82_RS03600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AOT82_RS03605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AOT82_RS03630	COG1012	belongs to the aldehyde dehydrogenase family
AOT82_RS03635	COG0531	amino acid
AOT82_RS03640	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AOT82_RS03645	COG1012	belongs to the aldehyde dehydrogenase family
AOT82_RS03660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AOT82_RS03675	COG0277	FAD linked oxidase domain protein
AOT82_RS03680	COG1620	l-lactate permease
AOT82_RS03685	COG0583	DNA-binding transcription factor activity
AOT82_RS03725	COG4650	regulator
AOT82_RS03735	COG1690	Belongs to the RtcB family
AOT82_RS03750	COG0430	RNA-3'-phosphate cyclase activity
AOT82_RS03755	COG0069	glutamate synthase activity
AOT82_RS03760	COG3698	Phosphodiester glycosidase
AOT82_RS03780	COG3100	YcgL domain-containing protein
AOT82_RS03790	COG0509	glycine decarboxylation via glycine cleavage system
AOT82_RS03795	COG0778	Nitroreductase
AOT82_RS03800	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT82_RS03800	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AOT82_RS03815	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
AOT82_RS03820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AOT82_RS03825	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AOT82_RS03835	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT82_RS03845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT82_RS03860	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOT82_RS03860	COG0616	signal peptide processing
AOT82_RS03865	COG2333	competence protein COMEC
AOT82_RS03865	COG0658	competence protein
AOT82_RS03880	COG1136	(ABC) transporter
AOT82_RS03885	COG4591	ABC-type transport system involved in lipoprotein release permease component
AOT82_RS03900	COG3278	Belongs to the heme-copper respiratory oxidase family
AOT82_RS03915	COG2010	Cytochrome c
AOT82_RS03920	COG0348	domain, Protein
AOT82_RS03930	COG0037	tRNA processing
AOT82_RS03935	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AOT82_RS03945	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AOT82_RS03955	COG0668	transmembrane transport
AOT82_RS03960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AOT82_RS03960	COG0116	Belongs to the methyltransferase superfamily
AOT82_RS04005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT82_RS04025	COG1358	cellular component organization or biogenesis
AOT82_RS04035	COG2267	carboxylic ester hydrolase activity
AOT82_RS04040	COG1024	Enoyl-CoA hydratase
AOT82_RS04050	COG1049	propionate catabolic process, 2-methylcitrate cycle
AOT82_RS04055	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AOT82_RS04060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AOT82_RS04075	COG2358	TRAP transporter, solute receptor (TAXI family
AOT82_RS04080	COG1902	pentaerythritol trinitrate reductase activity
AOT82_RS04095	COG2171	N-acyltransferase activity
AOT82_RS04100	COG0602	queuosine metabolic process
AOT82_RS04105	COG0697	spore germination
AOT82_RS04115	COG2860	membrane
AOT82_RS04145	COG0556	nucleotide-excision repair
AOT82_RS04150	COG0783	Belongs to the Dps family
AOT82_RS04160	COG1607	acyl-coa hydrolase
AOT82_RS04170	COG0583	DNA-binding transcription factor activity
AOT82_RS04175	COG2814	Major facilitator Superfamily
AOT82_RS04180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AOT82_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS04200	COG0436	Aminotransferase
AOT82_RS04210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AOT82_RS04215	COG0431	NADPH-dependent FMN reductase
AOT82_RS04245	COG0386	Belongs to the glutathione peroxidase family
AOT82_RS04250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT82_RS04255	COG0436	Aminotransferase
AOT82_RS04285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AOT82_RS04290	COG0277	FAD linked oxidase domain protein
AOT82_RS04295	COG2255	four-way junction helicase activity
AOT82_RS04300	COG0632	four-way junction helicase activity
AOT82_RS04305	COG0191	fructose-bisphosphate aldolase activity
AOT82_RS04315	COG0126	phosphoglycerate kinase activity
AOT82_RS04320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT82_RS04325	COG0352	thiamine-phosphate diphosphorylase activity
AOT82_RS04330	COG1686	Belongs to the peptidase S11 family
AOT82_RS04335	COG2197	response regulator
AOT82_RS04350	COG0793	Belongs to the peptidase S41A family
AOT82_RS04355	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AOT82_RS04370	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AOT82_RS04385	COG0450	alkyl hydroperoxide reductase
AOT82_RS04390	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT82_RS04400	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT82_RS04405	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AOT82_RS04410	COG1162	GTPase activity
AOT82_RS04425	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AOT82_RS04430	COG0563	adenylate kinase activity
AOT82_RS04460	COG0768	penicillin binding
AOT82_RS04465	COG0742	ribosomal rna small subunit methyltransferase
AOT82_RS04470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AOT82_RS04475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AOT82_RS04490	COG4122	O-methyltransferase activity
AOT82_RS04495	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AOT82_RS04500	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AOT82_RS04510	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AOT82_RS04515	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AOT82_RS04525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT82_RS04530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AOT82_RS04545	COG0435	Glutathione S-transferase
AOT82_RS04610	COG1518	maintenance of DNA repeat elements
AOT82_RS04615	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AOT82_RS04620	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AOT82_RS04625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AOT82_RS04665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AOT82_RS04665	COG1648	precorrin-2 dehydrogenase activity
AOT82_RS04670	COG0243	molybdopterin cofactor binding
AOT82_RS04675	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT82_RS04680	COG0515	serine threonine protein kinase
AOT82_RS04680	COG2815	serine threonine protein kinase
AOT82_RS04685	COG2223	nitrite transmembrane transporter activity
AOT82_RS04690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AOT82_RS04695	COG2146	nitrite reductase [NAD(P)H] activity
AOT82_RS04715	COG3321	synthase
AOT82_RS04715	COG0604	alcohol dehydrogenase
AOT82_RS04720	COG1063	alcohol dehydrogenase
AOT82_RS04725	COG0583	DNA-binding transcription factor activity
AOT82_RS04735	COG2963	transposase activity
AOT82_RS04740	COG4221	oxidoreductase activity
AOT82_RS04765	COG1063	alcohol dehydrogenase
AOT82_RS04805	COG2610	gluconate transmembrane transporter activity
AOT82_RS04820	COG4753	response regulator
AOT82_RS04820	COG2207	Transcriptional regulator
AOT82_RS04825	COG4191	Histidine kinase
AOT82_RS04835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AOT82_RS04845	COG0745	RESPONSE REGULATOR receiver
AOT82_RS04850	COG2205	protein histidine kinase activity
AOT82_RS04865	COG2010	Cytochrome c
AOT82_RS04885	COG0569	domain protein
AOT82_RS04890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AOT82_RS04900	COG1451	nucleotide metabolic process
AOT82_RS04905	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AOT82_RS04915	COG1012	belongs to the aldehyde dehydrogenase family
AOT82_RS04950	COG2932	Transcriptional regulator
AOT82_RS05010	COG4382	Mu-like prophage protein Gp16
AOT82_RS05050	COG4373	Mu-like prophage FluMu protein gp28
AOT82_RS05055	COG4383	Mu-like prophage protein gp29
AOT82_RS05065	COG5005	Phage virion morphogenesis
AOT82_RS05195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AOT82_RS05200	COG1012	belongs to the aldehyde dehydrogenase family
AOT82_RS05220	COG0601	transmembrane transport
AOT82_RS05225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AOT82_RS05235	COG4608	Belongs to the ABC transporter superfamily
AOT82_RS05255	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AOT82_RS05260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AOT82_RS05270	COG0783	Belongs to the Dps family
AOT82_RS05285	COG0628	permease
AOT82_RS05290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AOT82_RS05295	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AOT82_RS05300	COG1012	belongs to the aldehyde dehydrogenase family
AOT82_RS05330	COG3335	DDE superfamily endonuclease
AOT82_RS05340	COG0137	argininosuccinate synthase activity
AOT82_RS05365	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AOT82_RS05370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
AOT82_RS05375	COG0148	phosphopyruvate hydratase activity
AOT82_RS05380	COG2217	Heavy metal translocating P-type atpase
AOT82_RS05385	COG2217	Heavy metal translocating P-type atpase
AOT82_RS05395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AOT82_RS05405	COG0504	CTP synthase activity
AOT82_RS05450	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT82_RS05460	COG1304	FMN binding
AOT82_RS05465	COG0457	Tetratricopeptide repeat
AOT82_RS05465	COG0705	Rhomboid family
AOT82_RS05485	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AOT82_RS05495	COG2056	Na+-H+ antiporter family
AOT82_RS05550	COG4607	ABC-type enterochelin transport system periplasmic component
AOT82_RS05560	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AOT82_RS05565	COG4605	iron ion homeostasis
AOT82_RS05570	COG4604	ABC transporter, ATP-binding protein
AOT82_RS05605	COG1126	abc transporter atp-binding protein
AOT82_RS05610	COG0765	amino acid transport
AOT82_RS05615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT82_RS05625	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AOT82_RS05630	COG2986	histidine ammonia-lyase
AOT82_RS05635	COG0010	Belongs to the arginase family
AOT82_RS05640	COG1228	amidohydrolase
AOT82_RS05650	COG0840	transmembrane signaling receptor activity
AOT82_RS05675	COG0519	Catalyzes the synthesis of GMP from XMP
AOT82_RS05685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AOT82_RS05690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AOT82_RS05695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
AOT82_RS05700	COG2080	2 iron, 2 sulfur cluster binding
AOT82_RS05710	COG2801	Transposase and inactivated derivatives
AOT82_RS05730	COG0583	DNA-binding transcription factor activity
AOT82_RS05755	COG0714	Associated with various cellular activities
AOT82_RS05775	COG1509	lysine 2,3-aminomutase activity
AOT82_RS05780	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AOT82_RS05785	COG5002	protein histidine kinase activity
AOT82_RS05785	COG0784	Response regulator, receiver
AOT82_RS05790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
AOT82_RS05795	COG0084	hydrolase, TatD family'
AOT82_RS05835	COG0629	single-stranded DNA binding
AOT82_RS05840	COG2814	Major facilitator Superfamily
AOT82_RS05845	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AOT82_RS05900	COG1396	sequence-specific DNA binding
AOT82_RS05910	COG3657	addiction module killer protein
AOT82_RS05935	COG0285	dihydrofolate synthase activity
AOT82_RS05940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AOT82_RS05945	COG0159	tryptophan synthase activity
AOT82_RS05955	COG0135	phosphoribosylanthranilate isomerase activity
AOT82_RS05960	COG0415	Belongs to the DNA photolyase family
AOT82_RS05970	COG0442	prolyl-tRNA aminoacylation
AOT82_RS05975	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT82_RS05975	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AOT82_RS05980	COG0842	Transport permease protein
AOT82_RS05985	COG1131	(ABC) transporter
AOT82_RS06010	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AOT82_RS06030	COG1115	amino acid carrier protein
AOT82_RS06035	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AOT82_RS06040	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
AOT82_RS06065	COG0823	Involved in the tonB-independent uptake of proteins
AOT82_RS06085	COG0024	Methionine aminopeptidase
AOT82_RS06090	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AOT82_RS06100	COG0436	Aminotransferase
AOT82_RS06130	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AOT82_RS06135	COG3384	dioxygenase
AOT82_RS06145	COG1674	ftsk spoiiie
AOT82_RS06150	COG0492	ferredoxin-NADP+ reductase activity
AOT82_RS06155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AOT82_RS06160	COG0789	Transcriptional regulator
AOT82_RS06170	COG0678	peroxiredoxin activity
AOT82_RS06175	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT82_RS06220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AOT82_RS06230	COG1764	response to oxidative stress
AOT82_RS06250	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AOT82_RS06255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT82_RS06260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AOT82_RS06260	COG2813	Specifically methylates the guanine in position
AOT82_RS06275	COG1054	Belongs to the UPF0176 family
AOT82_RS06280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT82_RS06290	COG0277	FAD linked oxidase domain protein
AOT82_RS06300	COG3153	acetyltransferase
AOT82_RS06300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT82_RS06305	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AOT82_RS06310	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AOT82_RS06325	COG1278	Cold shock
AOT82_RS06335	COG0667	Aldo Keto reductase
AOT82_RS06345	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AOT82_RS06360	COG0739	heme binding
AOT82_RS06360	COG1196	nuclear chromosome segregation
AOT82_RS06360	COG0741	lytic transglycosylase activity
AOT82_RS06365	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AOT82_RS06370	COG0052	Belongs to the universal ribosomal protein uS2 family
AOT82_RS06385	COG2201	protein-glutamate methylesterase activity
AOT82_RS06390	COG0643	Histidine kinase
AOT82_RS06390	COG2198	Histidine kinase
AOT82_RS06395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT82_RS06400	COG2814	Major facilitator Superfamily
AOT82_RS06405	COG1024	Enoyl-CoA hydratase
AOT82_RS06415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AOT82_RS06425	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AOT82_RS06430	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT82_RS06435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AOT82_RS06445	COG1970	mechanosensitive ion channel activity
AOT82_RS06450	COG1217	gtp-binding protein TYPA
AOT82_RS06455	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
AOT82_RS06455	COG2885	chlorophyll binding
AOT82_RS06470	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AOT82_RS06475	COG0571	ribonuclease III activity
AOT82_RS06490	COG0481	GTPase activity
AOT82_RS06515	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AOT82_RS06525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AOT82_RS06530	COG2962	Rard protein
AOT82_RS06535	COG1522	sequence-specific DNA binding
AOT82_RS06550	COG0004	ammonium transporteR
AOT82_RS06580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AOT82_RS06590	COG1196	nuclear chromosome segregation
AOT82_RS06610	COG3335	DDE superfamily endonuclease
AOT82_RS06615	COG0730	response to heat
AOT82_RS06625	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AOT82_RS06630	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS06645	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
AOT82_RS06650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AOT82_RS06655	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS06665	COG1126	abc transporter atp-binding protein
AOT82_RS06670	COG0765	amino acid transport
AOT82_RS06675	COG0765	amino acid transport
AOT82_RS06680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT82_RS06685	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AOT82_RS06710	COG0179	Fumarylacetoacetate (FAA) hydrolase
AOT82_RS06725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT82_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AOT82_RS06750	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AOT82_RS06765	COG0786	glutamate:sodium symporter activity
AOT82_RS06780	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AOT82_RS06785	COG3161	chorismate lyase activity
AOT82_RS06810	COG1187	pseudouridine synthase activity
AOT82_RS06830	COG0793	Belongs to the peptidase S41A family
AOT82_RS06840	COG2885	chlorophyll binding
AOT82_RS06860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AOT82_RS06870	COG1671	Belongs to the UPF0178 family
AOT82_RS06880	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AOT82_RS06885	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AOT82_RS06890	COG0628	permease
AOT82_RS06900	COG1253	flavin adenine dinucleotide binding
AOT82_RS06905	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AOT82_RS06920	COG0735	belongs to the Fur family
AOT82_RS06925	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT82_RS06950	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AOT82_RS06955	COG0546	phosphoglycolate phosphatase activity
AOT82_RS06965	COG1530	ribonuclease E activity
AOT82_RS06970	COG2354	Protein conserved in bacteria
AOT82_RS06990	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
AOT82_RS07005	COG0653	protein targeting
AOT82_RS07010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AOT82_RS07030	COG4969	Belongs to the N-Me-Phe pilin family
AOT82_RS07080	COG4232	protein-disulfide reductase activity
AOT82_RS07085	COG2165	general secretion pathway protein
AOT82_RS07130	COG1401	restriction endodeoxyribonuclease activity
AOT82_RS07140	COG0251	oxidation-reduction process
AOT82_RS07150	COG2022	thiamine diphosphate biosynthetic process
AOT82_RS07155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AOT82_RS07165	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AOT82_RS07175	COG0408	coproporphyrinogen oxidase activity
AOT82_RS07185	COG0668	transmembrane transport
AOT82_RS07195	COG0288	reversible hydration of carbon dioxide
AOT82_RS07200	COG3842	ATPase activity
AOT82_RS07210	COG1177	transmembrane transport
AOT82_RS07215	COG0583	DNA-binding transcription factor activity
AOT82_RS07230	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AOT82_RS07235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AOT82_RS07250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AOT82_RS07260	COG4783	chaperone-mediated protein folding
AOT82_RS07265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AOT82_RS07265	COG0425	Belongs to the sulfur carrier protein TusA family
AOT82_RS07275	COG2363	Small membrane protein
AOT82_RS07295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AOT82_RS07300	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AOT82_RS07305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AOT82_RS07325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AOT82_RS07330	COG0857	belongs to the CobB CobQ family
AOT82_RS07330	COG0280	phosphate acetyltransferase
AOT82_RS07335	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AOT82_RS07345	COG2258	MOSC domain
AOT82_RS07365	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT82_RS07370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AOT82_RS07400	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
AOT82_RS07405	COG0047	phosphoribosylformylglycinamidine synthase activity
AOT82_RS07405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AOT82_RS07430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AOT82_RS07435	COG2081	HI0933 family
AOT82_RS07440	COG3676	manually curated
AOT82_RS07460	COG1902	pentaerythritol trinitrate reductase activity
AOT82_RS07480	COG0095	Lipoate-protein ligase
AOT82_RS07490	COG0446	pyridine nucleotide-disulphide oxidoreductase
AOT82_RS07490	COG1902	pentaerythritol trinitrate reductase activity
AOT82_RS07495	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS07515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AOT82_RS07530	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AOT82_RS07550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AOT82_RS07555	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AOT82_RS07560	COG0193	aminoacyl-tRNA hydrolase activity
AOT82_RS07565	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AOT82_RS07590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AOT82_RS07590	COG0352	thiamine-phosphate diphosphorylase activity
AOT82_RS07590	COG0351	phosphomethylpyrimidine kinase
AOT82_RS07595	COG0762	integral membrane protein
AOT82_RS07605	COG0037	tRNA processing
AOT82_RS07625	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS07630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AOT82_RS07635	COG2824	Alkylphosphonate utilization operon protein PhnA
AOT82_RS07645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT82_RS07650	COG3383	formate dehydrogenase (NAD+) activity
AOT82_RS07675	COG2963	transposase activity
AOT82_RS07690	COG2094	Belongs to the DNA glycosylase MPG family
AOT82_RS07700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AOT82_RS07710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AOT82_RS07715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AOT82_RS07720	COG3263	regulation of cellular component size
AOT82_RS07725	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AOT82_RS07730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AOT82_RS07765	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AOT82_RS07775	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS07790	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AOT82_RS07800	COG0488	(ABC) transporter
AOT82_RS07830	COG2154	pterin-4-alpha-carbinolamine dehydratase
AOT82_RS07835	COG5487	UPF0391 membrane protein
AOT82_RS07845	COG3268	Saccharopine dehydrogenase
AOT82_RS07855	COG2183	response to ionizing radiation
AOT82_RS07865	COG0523	cobalamin synthesis protein
AOT82_RS07870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AOT82_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS07890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT82_RS07905	COG1660	Displays ATPase and GTPase activities
AOT82_RS07910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AOT82_RS07915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AOT82_RS07920	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AOT82_RS07925	COG0617	tRNA 3'-terminal CCA addition
AOT82_RS07930	COG1596	polysaccharide export
AOT82_RS07930	COG1555	photosystem II stabilization
AOT82_RS07935	COG3956	TIGRFAM MazG family protein
AOT82_RS07945	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AOT82_RS07950	COG0166	Belongs to the GPI family
AOT82_RS07955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AOT82_RS07960	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AOT82_RS07965	COG0045	succinate-CoA ligase (ADP-forming) activity
AOT82_RS07985	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AOT82_RS07990	COG1053	succinate dehydrogenase
AOT82_RS07995	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AOT82_RS08045	COG0181	hydroxymethylbilane synthase activity
AOT82_RS08060	COG0165	Argininosuccinate lyase
AOT82_RS08065	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AOT82_RS08075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AOT82_RS08080	COG0581	inorganic phosphate transmembrane transporter activity
AOT82_RS08095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AOT82_RS08100	COG3588	fructose-bisphosphate aldolase
AOT82_RS08105	COG0697	spore germination
AOT82_RS08110	COG1132	(ABC) transporter
AOT82_RS08140	COG3568	Endonuclease Exonuclease Phosphatase
AOT82_RS08150	COG0339	signal peptide processing
AOT82_RS08170	COG1185	polyribonucleotide nucleotidyltransferase activity
AOT82_RS08175	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AOT82_RS08185	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AOT82_RS08190	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AOT82_RS08195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AOT82_RS08200	COG2251	uridine kinase activity
AOT82_RS08200	COG0195	Participates in both transcription termination and antitermination
AOT82_RS08205	COG0779	Required for maturation of 30S ribosomal subunits
AOT82_RS08240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AOT82_RS08245	COG0237	dephospho-CoA kinase activity
AOT82_RS08250	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT82_RS08255	COG3123	guanosine phosphorylase activity
AOT82_RS08260	COG0497	DNA recombination
AOT82_RS08265	COG1678	Uncharacterized ACR, COG1678
AOT82_RS08270	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AOT82_RS08280	COG0425	Belongs to the sulfur carrier protein TusA family
AOT82_RS08290	COG2814	Major facilitator Superfamily
AOT82_RS08300	COG2813	Specifically methylates the guanine in position
AOT82_RS08305	COG0795	lipopolysaccharide-transporting ATPase activity
AOT82_RS08310	COG0795	lipopolysaccharide-transporting ATPase activity
AOT82_RS08330	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AOT82_RS08340	COG0484	heat shock protein binding
AOT82_RS08360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AOT82_RS08365	COG0488	(ABC) transporter
AOT82_RS08370	COG0316	Belongs to the HesB IscA family
AOT82_RS08375	COG2918	glutathione biosynthetic process
AOT82_RS08380	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AOT82_RS08390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT82_RS08395	COG2261	transglycosylase associated protein
AOT82_RS08400	COG2801	Transposase and inactivated derivatives
AOT82_RS08410	COG0242	peptide deformylase activity
AOT82_RS08425	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AOT82_RS08430	COG0484	heat shock protein binding
AOT82_RS08450	COG1739	Uncharacterized protein family UPF0029
AOT82_RS08475	COG2070	2-Nitropropane dioxygenase
AOT82_RS08485	COG1794	racemase activity, acting on amino acids and derivatives
AOT82_RS08500	COG0604	alcohol dehydrogenase
AOT82_RS08510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AOT82_RS08510	COG0519	Catalyzes the synthesis of GMP from XMP
AOT82_RS08565	COG1024	Enoyl-CoA hydratase
AOT82_RS08575	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AOT82_RS08580	COG1971	Probably functions as a manganese efflux pump
AOT82_RS08585	COG0187	DNA topoisomerase II activity
AOT82_RS08595	COG0592	DNA-directed DNA polymerase activity
AOT82_RS08605	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AOT82_RS08610	COG0594	ribonuclease P activity
AOT82_RS08615	COG0706	membrane insertase activity
AOT82_RS08620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AOT82_RS08625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AOT82_RS08630	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT82_RS08630	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AOT82_RS08640	COG0784	Response regulator, receiver
AOT82_RS08640	COG2205	protein histidine kinase activity
AOT82_RS08640	COG5002	protein histidine kinase activity
AOT82_RS08660	COG1652	LysM domain
AOT82_RS08665	COG0758	DNA mediated transformation
AOT82_RS08670	COG0009	L-threonylcarbamoyladenylate synthase
AOT82_RS08675	COG1090	epimerase
AOT82_RS08680	COG1408	metallophosphoesterase
AOT82_RS08695	COG0443	Heat shock 70 kDa protein
AOT82_RS08700	COG4106	trans-aconitate 2-methyltransferase activity
AOT82_RS08725	COG0330	HflC and HflK could
AOT82_RS08735	COG0606	chelatase, subunit chli
AOT82_RS08740	COG0546	phosphoglycolate phosphatase activity
AOT82_RS08760	COG0131	Imidazoleglycerol-phosphate dehydratase
AOT82_RS08765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AOT82_RS08785	COG3977	Valine--pyruvate aminotransferase
AOT82_RS08805	COG1136	(ABC) transporter
AOT82_RS08810	COG2755	lipolytic protein G-D-S-L family
AOT82_RS08815	COG2807	transmembrane transport
AOT82_RS08825	COG1477	protein flavinylation
AOT82_RS08830	COG0300	oxidoreductase activity
AOT82_RS08835	COG2871	sodium ion transport
AOT82_RS08840	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AOT82_RS08860	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
AOT82_RS08865	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AOT82_RS08880	COG0557	exoribonuclease II activity
AOT82_RS08890	COG3335	DDE superfamily endonuclease
AOT82_RS08905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AOT82_RS09000	COG3676	manually curated
AOT82_RS09005	COG3313	Fe-S protein
AOT82_RS09010	COG3150	esterase
AOT82_RS09025	COG2801	Transposase and inactivated derivatives
AOT82_RS09035	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS09045	COG0668	transmembrane transport
AOT82_RS09055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AOT82_RS09055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOT82_RS09065	COG1752	Esterase of the alpha-beta hydrolase superfamily
AOT82_RS09070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AOT82_RS09105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AOT82_RS09110	COG0730	response to heat
AOT82_RS09140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AOT82_RS09145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AOT82_RS09150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AOT82_RS09155	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AOT82_RS09160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AOT82_RS09170	COG0107	imidazoleglycerol-phosphate synthase activity
AOT82_RS09175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AOT82_RS09185	COG0121	glutamine amidotransferase
AOT82_RS09205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AOT82_RS09215	COG3541	Predicted nucleotidyltransferase
AOT82_RS09245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT82_RS09250	COG0275	rRNA processing
AOT82_RS09265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AOT82_RS09270	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AOT82_RS09275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AOT82_RS09280	COG2226	methyltransferase
AOT82_RS09335	COG0732	type I restriction modification DNA specificity domain
AOT82_RS09365	COG3335	DDE superfamily endonuclease
AOT82_RS09410	COG0789	Transcriptional regulator
AOT82_RS09460	COG0582	viral genome integration into host DNA
AOT82_RS09485	COG0004	ammonium transporteR
AOT82_RS09500	COG0659	secondary active sulfate transmembrane transporter activity
AOT82_RS09505	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AOT82_RS09510	COG0772	Belongs to the SEDS family
AOT82_RS09515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AOT82_RS09525	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AOT82_RS09530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AOT82_RS09535	COG1121	(ABC) transporter
AOT82_RS09555	COG0356	it plays a direct role in the translocation of protons across the membrane
AOT82_RS09565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AOT82_RS09570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AOT82_RS09575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AOT82_RS09580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AOT82_RS09585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AOT82_RS09590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AOT82_RS09595	COG0745	RESPONSE REGULATOR receiver
AOT82_RS09600	COG2205	protein histidine kinase activity
AOT82_RS09615	COG0228	four-way junction DNA binding
AOT82_RS09620	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AOT82_RS09625	COG0336	Belongs to the RNA methyltransferase TrmD family
AOT82_RS09630	COG0335	large ribosomal subunit rRNA binding
AOT82_RS09645	COG0322	excinuclease ABC activity
AOT82_RS09650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
AOT82_RS09655	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AOT82_RS09665	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AOT82_RS09670	COG0410	ABC transporter
AOT82_RS09705	COG0494	nUDIX hydrolase
AOT82_RS09715	COG1765	OsmC-like protein
AOT82_RS09725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AOT82_RS09740	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT82_RS09745	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AOT82_RS09750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AOT82_RS09760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AOT82_RS09765	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AOT82_RS09770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AOT82_RS09775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AOT82_RS09775	COG0072	phenylalanine-tRNA ligase activity
AOT82_RS09780	COG0776	regulation of translation
AOT82_RS09790	COG2321	neutral zinc metallopeptidase
AOT82_RS09805	COG3118	belongs to the thioredoxin family
AOT82_RS09810	COG0564	pseudouridine synthase activity
AOT82_RS09820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AOT82_RS09830	COG1946	Acyl-CoA thioesterase
AOT82_RS09850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
AOT82_RS09865	COG2983	Belongs to the UPF0260 family
AOT82_RS09880	COG4535	Mg2 and Co2 transporter CorC
AOT82_RS09885	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AOT82_RS09910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AOT82_RS09915	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AOT82_RS09920	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AOT82_RS09945	COG4221	oxidoreductase activity
AOT82_RS10015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AOT82_RS10030	COG0644	oxidoreductase
AOT82_RS10030	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
AOT82_RS10040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AOT82_RS10060	COG2801	Transposase and inactivated derivatives
AOT82_RS10065	COG2951	lytic endotransglycosylase activity
AOT82_RS10070	COG0500	methyltransferase
AOT82_RS10075	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AOT82_RS10080	COG4106	trans-aconitate 2-methyltransferase activity
AOT82_RS10085	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT82_RS10100	COG0018	arginyl-trna synthetase
AOT82_RS10120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AOT82_RS10125	COG0740	serine-type endopeptidase activity
AOT82_RS10130	COG0829	nickel cation binding
AOT82_RS10135	COG0831	urea catabolic process
AOT82_RS10140	COG0832	Belongs to the urease beta subunit family
AOT82_RS10140	COG0804	urea catabolic process
AOT82_RS10145	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AOT82_RS10150	COG0830	nickel cation binding
AOT82_RS10165	COG0544	peptidyl-prolyl cis-trans isomerase activity
AOT82_RS10175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AOT82_RS10190	COG0142	geranyltranstransferase activity
AOT82_RS10195	COG1024	Enoyl-CoA hydratase
AOT82_RS10195	COG1250	3-hydroxyacyl-CoA dehydrogenase
AOT82_RS10200	COG0183	Belongs to the thiolase family
AOT82_RS10215	COG0688	phosphatidylethanolamine metabolic process
AOT82_RS10220	COG1490	D-aminoacyl-tRNA deacylase activity
AOT82_RS10265	COG2353	YceI-like domain
AOT82_RS10270	COG0254	rRNA binding
AOT82_RS10285	COG1051	belongs to the nudix hydrolase family
AOT82_RS10285	COG1056	cytidyltransferase-related domain
AOT82_RS10295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AOT82_RS10305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AOT82_RS10315	COG0792	nuclease activity
AOT82_RS10335	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AOT82_RS10340	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AOT82_RS10345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AOT82_RS10350	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AOT82_RS10370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AOT82_RS10375	COG0049	tRNA binding
AOT82_RS10380	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AOT82_RS10385	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AOT82_RS10405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AOT82_RS10410	COG0081	regulation of translation
AOT82_RS10415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AOT82_RS10420	COG0222	ribosome binding
AOT82_RS10425	COG0085	RNA polymerase activity
AOT82_RS10430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AOT82_RS10470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AOT82_RS10475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AOT82_RS10485	COG0067	glutamate synthase
AOT82_RS10485	COG0069	glutamate synthase activity
AOT82_RS10485	COG0070	glutamate synthase
AOT82_RS10490	COG0493	'glutamate synthase
AOT82_RS10505	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS10535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AOT82_RS10540	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS10545	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS10550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AOT82_RS10565	COG1981	membrane
AOT82_RS10570	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AOT82_RS10590	COG3830	Belongs to the UPF0237 family
AOT82_RS10590	COG0560	Phosphoserine phosphatase
AOT82_RS10610	COG0393	Putative heavy-metal-binding
AOT82_RS10620	COG0385	Bile acid
AOT82_RS10630	COG0525	valine-tRNA ligase activity
AOT82_RS10640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AOT82_RS10645	COG2832	Protein of unknown function (DUF454)
AOT82_RS10650	COG1278	Cold shock
AOT82_RS10660	COG0583	DNA-binding transcription factor activity
AOT82_RS10685	COG1028	Short-chain dehydrogenase reductase Sdr
AOT82_RS10690	COG0494	nUDIX hydrolase
AOT82_RS10700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AOT82_RS10705	COG0730	response to heat
AOT82_RS10710	COG1301	dicarboxylic acid transport
AOT82_RS10715	COG1960	acyl-CoA dehydrogenase activity
AOT82_RS10720	COG2003	Belongs to the UPF0758 family
AOT82_RS10725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AOT82_RS10740	COG0123	including yeast histone deacetylase and acetoin utilization protein
AOT82_RS10755	COG4133	protoheme IX ABC transporter activity
AOT82_RS10775	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AOT82_RS10780	COG0656	L-ascorbic acid biosynthetic process
AOT82_RS10785	COG1464	Belongs to the NlpA lipoprotein family
AOT82_RS10790	COG2011	ABC-type metal ion transport system permease component
AOT82_RS10795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AOT82_RS10805	COG0745	RESPONSE REGULATOR receiver
AOT82_RS10830	COG0840	transmembrane signaling receptor activity
AOT82_RS10845	COG2201	protein-glutamate methylesterase activity
AOT82_RS10860	COG3038	cytochrome b561
AOT82_RS10865	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AOT82_RS10885	COG0204	Acyl-transferase
AOT82_RS10890	COG2885	chlorophyll binding
AOT82_RS10895	COG3487	Iron-regulated protein
AOT82_RS10930	COG0583	DNA-binding transcription factor activity
AOT82_RS10935	COG0450	alkyl hydroperoxide reductase
AOT82_RS10950	COG1115	amino acid carrier protein
AOT82_RS10970	COG0659	secondary active sulfate transmembrane transporter activity
AOT82_RS10975	COG0640	Transcriptional regulator
AOT82_RS11045	COG0583	DNA-binding transcription factor activity
AOT82_RS11050	COG1741	Belongs to the pirin family
AOT82_RS11080	COG1983	PspC domain protein
AOT82_RS11085	COG0752	glycyl-tRNA synthetase alpha subunit
AOT82_RS11110	COG3079	Belongs to the UPF0149 family
AOT82_RS11115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT82_RS11120	COG1280	lysine exporter protein (LysE YggA)
AOT82_RS11130	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT82_RS11135	COG0741	lytic transglycosylase activity
AOT82_RS11135	COG1196	nuclear chromosome segregation
AOT82_RS11135	COG0739	heme binding
AOT82_RS11145	COG0039	L-malate dehydrogenase activity
AOT82_RS11155	COG0196	riboflavin kinase activity
AOT82_RS11160	COG1247	-acetyltransferase
AOT82_RS11170	COG0728	peptidoglycan biosynthetic process
AOT82_RS11175	COG3023	N-Acetylmuramoyl-L-alanine amidase
AOT82_RS11185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT82_RS11200	COG0189	ligase activity
AOT82_RS11205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AOT82_RS11210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AOT82_RS11215	COG1181	Belongs to the D-alanine--D-alanine ligase family
AOT82_RS11220	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
AOT82_RS11230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AOT82_RS11235	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AOT82_RS11260	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AOT82_RS11265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AOT82_RS11270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AOT82_RS11275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AOT82_RS11290	COG2137	regulation of response to DNA damage stimulus
AOT82_RS11295	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AOT82_RS11300	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AOT82_RS11330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AOT82_RS11340	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AOT82_RS11345	COG1758	RNA polymerase activity
AOT82_RS11350	COG0194	GDP metabolic process
AOT82_RS11355	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AOT82_RS11370	COG0326	Molecular chaperone. Has ATPase activity
AOT82_RS11380	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AOT82_RS11390	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AOT82_RS11410	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AOT82_RS11415	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AOT82_RS11420	COG2373	Large extracellular alpha-helical protein
AOT82_RS11420	COG4932	domain protein
AOT82_RS11420	COG1388	LysM domain
AOT82_RS11435	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AOT82_RS11440	COG1214	PFAM Peptidase M22, glycoprotease
AOT82_RS11445	COG1968	undecaprenyl-diphosphatase activity
AOT82_RS11450	COG0742	ribosomal rna small subunit methyltransferase
AOT82_RS11460	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AOT82_RS11480	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AOT82_RS11480	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AOT82_RS11490	COG2350	Protein conserved in bacteria
AOT82_RS11495	COG2917	probably involved in intracellular septation
AOT82_RS11500	COG0613	PHP domain protein
AOT82_RS11510	COG0585	pseudouridine synthase activity
AOT82_RS11530	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AOT82_RS11535	COG3610	response to peptide
AOT82_RS11540	COG2966	Psort location CytoplasmicMembrane, score
AOT82_RS11585	COG0582	viral genome integration into host DNA
AOT82_RS11595	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOT82_RS11600	COG0154	amidase activity
AOT82_RS11605	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AOT82_RS11610	COG1077	Cell shape determining protein MreB Mrl
AOT82_RS11615	COG1792	Involved in formation and maintenance of cell shape
AOT82_RS11625	COG0424	maF-like protein
AOT82_RS11630	COG1530	ribonuclease E activity
AOT82_RS11635	COG0051	transcription antitermination factor activity, RNA binding
AOT82_RS11640	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AOT82_RS11645	COG0088	Forms part of the polypeptide exit tunnel
AOT82_RS11650	COG0089	rRNA binding
AOT82_RS11655	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AOT82_RS11660	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AOT82_RS11665	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AOT82_RS11670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AOT82_RS11675	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AOT82_RS11680	COG0255	Belongs to the universal ribosomal protein uL29 family
AOT82_RS11685	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AOT82_RS11690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AOT82_RS11695	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AOT82_RS11700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AOT82_RS11705	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AOT82_RS11710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AOT82_RS11715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AOT82_RS11720	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AOT82_RS11725	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AOT82_RS11730	COG1841	ribosomal large subunit assembly
AOT82_RS11735	COG0200	Binds to the 23S rRNA
AOT82_RS11745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AOT82_RS11750	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AOT82_RS11755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AOT82_RS11760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AOT82_RS11765	COG0202	RNA polymerase activity
AOT82_RS11770	COG0203	ribosomal protein L17
AOT82_RS11775	COG0009	L-threonylcarbamoyladenylate synthase
AOT82_RS11780	COG3101	peptidyl-lysine hydroxylation
AOT82_RS11785	COG1399	metal-binding, possibly nucleic acid-binding protein
AOT82_RS11790	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AOT82_RS11810	COG1652	LysM domain
AOT82_RS11820	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AOT82_RS11820	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AOT82_RS11830	COG0028	Belongs to the TPP enzyme family
AOT82_RS11840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AOT82_RS11850	COG1278	Cold shock
AOT82_RS11920	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AOT82_RS11925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AOT82_RS11930	COG0540	Belongs to the ATCase OTCase family
AOT82_RS11960	COG1295	ribonuclease BN
AOT82_RS11980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AOT82_RS11985	COG0459	protein refolding
AOT82_RS12005	COG3022	response to hydroperoxide
AOT82_RS12030	COG2975	iron-sulfur cluster assembly
AOT82_RS12040	COG4772	TonB-dependent receptor
AOT82_RS12045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AOT82_RS12055	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AOT82_RS12060	COG1183	phosphatidylcholine synthase activity
AOT82_RS12115	COG0753	catalase activity
AOT82_RS12135	COG0577	efflux transmembrane transporter activity
AOT82_RS12135	COG1136	(ABC) transporter
AOT82_RS12140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AOT82_RS12145	COG2963	transposase activity
AOT82_RS12165	COG0495	leucyl-tRNA aminoacylation
AOT82_RS12175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AOT82_RS12185	COG0756	dUTP diphosphatase activity
AOT82_RS12190	COG2239	Acts as a magnesium transporter
AOT82_RS12195	COG0210	DNA helicase
AOT82_RS12210	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT82_RS12215	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT82_RS12220	COG0649	NAD binding
AOT82_RS12220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT82_RS12230	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
AOT82_RS12240	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AOT82_RS12245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT82_RS12250	COG0839	Belongs to the complex I subunit 6 family
AOT82_RS12255	COG0713	ATP synthesis coupled electron transport
AOT82_RS12265	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AOT82_RS12270	COG1007	ATP synthesis coupled electron transport
AOT82_RS12290	COG0668	transmembrane transport
AOT82_RS12295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AOT82_RS12300	COG1702	phosphate starvation-inducible protein PhoH
AOT82_RS12305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT82_RS12310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AOT82_RS12325	COG2431	L-lysine efflux transmembrane transporter activity
AOT82_RS12355	COG2095	MarC family integral membrane protein
AOT82_RS12380	COG1187	pseudouridine synthase activity
AOT82_RS12385	COG1596	polysaccharide export
AOT82_RS12415	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
AOT82_RS12435	COG1216	Glycosyl transferase, family 2
AOT82_RS12435	COG1442	glycosyl transferase family 8
AOT82_RS12455	COG0438	transferase activity, transferring glycosyl groups
AOT82_RS12465	COG1216	Glycosyl transferase, family 2
AOT82_RS12475	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AOT82_RS12480	COG0297	glycogen (starch) synthase activity
AOT82_RS12485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AOT82_RS12490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AOT82_RS12490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AOT82_RS12505	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AOT82_RS12515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AOT82_RS12525	COG0598	Magnesium transport protein CorA
AOT82_RS12535	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AOT82_RS12540	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AOT82_RS12555	COG0105	UTP biosynthetic process
AOT82_RS12560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AOT82_RS12575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AOT82_RS12580	COG0124	histidyl-tRNA synthetase
AOT82_RS12590	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AOT82_RS12595	COG1160	GTP binding
AOT82_RS12600	COG2205	protein histidine kinase activity
AOT82_RS12600	COG0784	Response regulator, receiver
AOT82_RS12605	COG1686	Belongs to the peptidase S11 family
AOT82_RS12640	COG0521	Mo-molybdopterin cofactor biosynthetic process
AOT82_RS12650	COG0315	cyclic pyranopterin monophosphate synthase activity
AOT82_RS12660	COG0314	molybdopterin synthase activity
AOT82_RS12680	COG2963	transposase activity
AOT82_RS12685	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AOT82_RS12725	COG3335	DDE superfamily endonuclease
AOT82_RS12745	COG1401	restriction endodeoxyribonuclease activity
AOT82_RS12765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AOT82_RS12775	COG1519	Transferase
AOT82_RS12780	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AOT82_RS12790	COG1178	ABC-type Fe3 transport system permease component
AOT82_RS12795	COG3842	ATPase activity
AOT82_RS12800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AOT82_RS12815	COG2962	Rard protein
AOT82_RS12820	COG2962	Rard protein
AOT82_RS12835	COG1234	tRNA 3'-trailer cleavage
AOT82_RS12845	COG0515	serine threonine protein kinase
AOT82_RS12845	COG2815	serine threonine protein kinase
AOT82_RS12855	COG2204	response regulator
AOT82_RS12860	COG3852	Histidine kinase
AOT82_RS12865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AOT82_RS12870	COG0528	UMP kinase activity
AOT82_RS12875	COG0233	cytoplasmic translational termination
AOT82_RS12880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AOT82_RS12885	COG0575	Belongs to the CDS family
AOT82_RS12890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AOT82_RS12905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT82_RS12910	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AOT82_RS12915	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AOT82_RS12920	COG0733	neurotransmitter:sodium symporter activity
AOT82_RS12925	COG0343	queuine tRNA-ribosyltransferase activity
AOT82_RS12945	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT82_RS12950	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AOT82_RS12955	COG3178	'Phosphotransferase
AOT82_RS12960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AOT82_RS12965	COG1294	oxidase, subunit
AOT82_RS12970	COG1271	oxidase subunit
AOT82_RS12985	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AOT82_RS13000	COG2911	Protein conserved in bacteria
AOT82_RS13010	COG3040	lipid binding
AOT82_RS13020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AOT82_RS13025	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AOT82_RS13030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AOT82_RS13035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AOT82_RS13045	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AOT82_RS13050	COG0542	response to heat
AOT82_RS13075	COG0776	regulation of translation
AOT82_RS13085	COG0284	orotidine-5'-phosphate decarboxylase activity
AOT82_RS13100	COG0268	Binds directly to 16S ribosomal RNA
AOT82_RS13105	COG0702	epimerase
AOT82_RS13110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AOT82_RS13115	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AOT82_RS13130	COG0633	Ferredoxin
AOT82_RS13145	COG0316	Belongs to the HesB IscA family
AOT82_RS13150	COG0822	iron-sulfur transferase activity
AOT82_RS13160	COG1959	2 iron, 2 sulfur cluster binding
AOT82_RS13175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AOT82_RS13180	COG0138	bifunctional purine biosynthesis protein purh
AOT82_RS13185	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
AOT82_RS13195	COG2264	protein methyltransferase activity
AOT82_RS13205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AOT82_RS13225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AOT82_RS13230	COG3139	Protein of unknown function (DUF1315)
AOT82_RS13240	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AOT82_RS13245	COG0527	aspartate kinase activity
AOT82_RS13250	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AOT82_RS13275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AOT82_RS13285	COG2205	protein histidine kinase activity
AOT82_RS13290	COG0745	RESPONSE REGULATOR receiver
AOT82_RS13300	COG0596	Alpha beta hydrolase
AOT82_RS13320	COG0318	PFAM AMP-dependent synthetase and ligase
AOT82_RS13330	COG2851	Citrate transporter
AOT82_RS13355	COG3335	DDE superfamily endonuclease
AOT82_RS13375	COG2963	transposase activity
AOT82_RS13440	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AOT82_RS13475	COG3335	DDE superfamily endonuclease
AOT82_RS13495	COG2963	transposase activity