locus-tag	class	description
AA042_RS00060	COG2111	Na H antiporter
AA042_RS00060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AA042_RS00065	COG1006	Multisubunit Na H antiporter MnhC subunit
AA042_RS00070	COG0651	ATP synthesis coupled electron transport
AA042_RS00080	COG2212	antiporter activity
AA042_RS00085	COG1320	monovalent cation:proton antiporter activity
AA042_RS00090	COG0471	metal ion transport
AA042_RS00110	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
AA042_RS00120	COG3447	MASE1 domain protein
AA042_RS00120	COG5001	Diguanylate cyclase
AA042_RS00120	COG5002	protein histidine kinase activity
AA042_RS00160	COG1126	abc transporter atp-binding protein
AA042_RS00165	COG0768	penicillin binding
AA042_RS00170	COG0402	S-adenosylhomocysteine deaminase activity
AA042_RS00180	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
AA042_RS00190	COG0583	DNA-binding transcription factor activity
AA042_RS00220	COG3757	hydrolase, family 25
AA042_RS00235	COG0322	excinuclease ABC activity
AA042_RS00240	COG2197	response regulator
AA042_RS00255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA042_RS00260	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
AA042_RS00265	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA042_RS00270	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS00275	COG1024	Enoyl-CoA hydratase
AA042_RS00280	COG1960	acyl-CoA dehydrogenase activity
AA042_RS00285	COG1024	Enoyl-CoA hydratase
AA042_RS00290	COG1960	acyl-CoA dehydrogenase activity
AA042_RS00295	COG0183	Belongs to the thiolase family
AA042_RS00305	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA042_RS00310	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AA042_RS00340	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
AA042_RS00355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA042_RS00375	COG0697	spore germination
AA042_RS00380	COG0583	DNA-binding transcription factor activity
AA042_RS00395	COG1126	abc transporter atp-binding protein
AA042_RS00410	COG1414	Transcriptional regulator
AA042_RS00415	COG0701	Predicted permease
AA042_RS00425	COG0659	secondary active sulfate transmembrane transporter activity
AA042_RS00430	COG2207	Transcriptional regulator
AA042_RS00440	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS00465	COG0534	Mate efflux family protein
AA042_RS00470	COG0183	Belongs to the thiolase family
AA042_RS00485	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS00490	COG0183	Belongs to the thiolase family
AA042_RS00495	COG1960	acyl-CoA dehydrogenase activity
AA042_RS00505	COG1024	Enoyl-CoA hydratase
AA042_RS00510	COG1695	Transcriptional regulator
AA042_RS00540	COG1960	acyl-CoA dehydrogenase activity
AA042_RS00545	COG1960	acyl-CoA dehydrogenase activity
AA042_RS00595	COG4211	Belongs to the binding-protein-dependent transport system permease family
AA042_RS00600	COG1129	ABC transporter
AA042_RS00615	COG0673	inositol 2-dehydrogenase activity
AA042_RS00630	COG3718	enzyme involved in inositol metabolism
AA042_RS00665	COG5001	Diguanylate cyclase
AA042_RS00670	COG1538	Outer membrane efflux protein
AA042_RS00705	COG3278	Belongs to the heme-copper respiratory oxidase family
AA042_RS00715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AA042_RS00725	COG0814	amino acid
AA042_RS00740	COG0297	glycogen (starch) synthase activity
AA042_RS00745	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA042_RS00790	COG3568	Endonuclease Exonuclease Phosphatase
AA042_RS00795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AA042_RS00800	COG0366	Alpha amylase catalytic
AA042_RS00830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS00845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS00860	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AA042_RS00875	COG0393	Putative heavy-metal-binding
AA042_RS00880	COG1611	Belongs to the LOG family
AA042_RS00890	COG3179	chitinase
AA042_RS00900	COG1522	sequence-specific DNA binding
AA042_RS00925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
AA042_RS00995	COG3209	COG3209 Rhs family protein
AA042_RS01040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS01050	COG1253	flavin adenine dinucleotide binding
AA042_RS01060	COG0583	DNA-binding transcription factor activity
AA042_RS01070	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
AA042_RS01085	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA042_RS01110	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
AA042_RS01115	COG0783	Belongs to the Dps family
AA042_RS01125	COG1686	Belongs to the peptidase S11 family
AA042_RS01130	COG3706	GGDEF domain
AA042_RS01170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA042_RS01175	COG1914	H( )-stimulated, divalent metal cation uptake system
AA042_RS01235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA042_RS01260	COG1397	ADP-ribosylglycohydrolase
AA042_RS01290	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
AA042_RS01295	COG0022	dehydrogenase e1 component
AA042_RS01305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA042_RS01310	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AA042_RS01315	COG2233	PERMEase
AA042_RS01325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA042_RS01330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA042_RS01370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA042_RS01380	COG0747	negative chemotaxis
AA042_RS01390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS01395	COG0697	spore germination
AA042_RS01430	COG0776	regulation of translation
AA042_RS01435	COG0072	phenylalanine-tRNA ligase activity
AA042_RS01440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AA042_RS01445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AA042_RS01450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AA042_RS01455	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AA042_RS01460	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AA042_RS01475	COG1278	Cold shock
AA042_RS01495	COG1869	D-ribose catabolic process
AA042_RS01500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA042_RS01510	COG1172	Belongs to the binding-protein-dependent transport system permease family
AA042_RS01515	COG1129	ABC transporter
AA042_RS01540	COG1113	amino acid transport
AA042_RS01545	COG0642	Histidine kinase
AA042_RS01600	COG3123	guanosine phosphorylase activity
AA042_RS01610	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA042_RS01620	COG0425	Belongs to the sulfur carrier protein TusA family
AA042_RS01625	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
AA042_RS01640	COG0840	transmembrane signaling receptor activity
AA042_RS01650	COG3278	Belongs to the heme-copper respiratory oxidase family
AA042_RS01665	COG2010	Cytochrome c
AA042_RS01670	COG3278	Belongs to the heme-copper respiratory oxidase family
AA042_RS01685	COG2010	Cytochrome c
AA042_RS01725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA042_RS01730	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA042_RS01735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AA042_RS01740	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AA042_RS01745	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AA042_RS01760	COG0840	transmembrane signaling receptor activity
AA042_RS01780	COG3115	cell septum assembly
AA042_RS01785	COG1196	nuclear chromosome segregation
AA042_RS01800	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AA042_RS01810	COG0402	S-adenosylhomocysteine deaminase activity
AA042_RS01815	COG1802	Transcriptional regulator
AA042_RS01820	COG3135	benzoate transporter
AA042_RS01830	COG2130	NADP-dependent
AA042_RS01835	COG0284	orotidine-5'-phosphate decarboxylase activity
AA042_RS01860	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AA042_RS01885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA042_RS01915	COG2244	polysaccharide biosynthetic process
AA042_RS01925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA042_RS01935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AA042_RS01945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
AA042_RS01960	COG0776	regulation of translation
AA042_RS01970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AA042_RS01975	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AA042_RS01980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA042_RS01990	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AA042_RS02000	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AA042_RS02005	COG0402	S-adenosylhomocysteine deaminase activity
AA042_RS02010	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA042_RS02015	COG0546	phosphoglycolate phosphatase activity
AA042_RS02020	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS02050	COG0271	Belongs to the BolA IbaG family
AA042_RS02060	COG0114	fumarate hydratase activity
AA042_RS02065	COG2326	polyphosphate kinase activity
AA042_RS02070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
AA042_RS02070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS02080	COG0367	asparagine synthase
AA042_RS02085	COG0189	ligase activity
AA042_RS02085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA042_RS02095	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AA042_RS02095	COG1648	precorrin-2 dehydrogenase activity
AA042_RS02100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AA042_RS02105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AA042_RS02110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AA042_RS02115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AA042_RS02120	COG1674	ftsk spoiiie
AA042_RS02125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AA042_RS02130	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
AA042_RS02135	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AA042_RS02140	COG0542	response to heat
AA042_RS02145	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AA042_RS02150	COG1278	Cold shock
AA042_RS02170	COG0482	sulfurtransferase activity
AA042_RS02175	COG2915	High frequency lysogenization protein hflD homolog
AA042_RS02185	COG2850	peptidyl-arginine hydroxylation
AA042_RS02190	COG2153	protein acetylation
AA042_RS02205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA042_RS02210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA042_RS02215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA042_RS02215	COG0649	NAD binding
AA042_RS02230	COG1034	ATP synthesis coupled electron transport
AA042_RS02235	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AA042_RS02240	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AA042_RS02250	COG0713	ATP synthesis coupled electron transport
AA042_RS02265	COG1007	ATP synthesis coupled electron transport
AA042_RS02305	COG0326	Molecular chaperone. Has ATPase activity
AA042_RS02335	COG0045	succinate-CoA ligase (ADP-forming) activity
AA042_RS02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA042_RS02355	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AA042_RS02360	COG1053	succinate dehydrogenase
AA042_RS02365	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
AA042_RS02370	COG2009	succinate dehydrogenase
AA042_RS02380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA042_RS02385	COG3162	membrane
AA042_RS02390	COG2113	Glycine betaine
AA042_RS02410	COG2853	Lipoprotein
AA042_RS02455	COG3121	Chaperone
AA042_RS02465	COG3539	Fimbrial protein
AA042_RS02490	COG1560	Kdo2-lipid A biosynthetic process
AA042_RS02495	COG0850	regulation of cytokinetic process
AA042_RS02500	COG2894	cell division
AA042_RS02505	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
AA042_RS02510	COG0564	pseudouridine synthase activity
AA042_RS02515	COG1362	aminopeptidase activity
AA042_RS02525	COG0668	transmembrane transport
AA042_RS02545	COG0395	ABC-type sugar transport system, permease component
AA042_RS02565	COG0604	alcohol dehydrogenase
AA042_RS02565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
AA042_RS02565	COG4221	oxidoreductase activity
AA042_RS02565	COG3321	synthase
AA042_RS02595	COG2010	Cytochrome c
AA042_RS02635	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
AA042_RS02660	COG1376	ErfK ybiS ycfS ynhG family protein
AA042_RS02675	COG4181	ATPase activity
AA042_RS02680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
AA042_RS02705	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AA042_RS02710	COG0084	hydrolase, TatD family'
AA042_RS02715	COG0840	transmembrane signaling receptor activity
AA042_RS02750	COG2205	protein histidine kinase activity
AA042_RS02755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AA042_RS02780	COG2983	Belongs to the UPF0260 family
AA042_RS02795	COG3100	YcgL domain-containing protein
AA042_RS02815	COG0174	glutamine synthetase
AA042_RS02820	COG0028	Belongs to the TPP enzyme family
AA042_RS02825	COG1253	flavin adenine dinucleotide binding
AA042_RS02835	COG0024	Methionine aminopeptidase
AA042_RS02850	COG3209	COG3209 Rhs family protein
AA042_RS02890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AA042_RS02895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AA042_RS02900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
AA042_RS02905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA042_RS02915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AA042_RS02920	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA042_RS02920	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AA042_RS02925	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
AA042_RS02940	COG4591	ABC-type transport system involved in lipoprotein release permease component
AA042_RS02945	COG1136	(ABC) transporter
AA042_RS02950	COG4591	ABC-type transport system involved in lipoprotein release permease component
AA042_RS02960	COG0584	glycerophosphoryl diester phosphodiesterase
AA042_RS02965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AA042_RS02990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA042_RS02995	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AA042_RS03040	COG0183	Belongs to the thiolase family
AA042_RS03045	COG1250	3-hydroxyacyl-CoA dehydrogenase
AA042_RS03045	COG1024	Enoyl-CoA hydratase
AA042_RS03055	COG0589	response to stress
AA042_RS03065	COG0741	lytic transglycosylase activity
AA042_RS03085	COG3851	Histidine kinase
AA042_RS03090	COG2197	response regulator
AA042_RS03095	COG1597	lipid kinase activity
AA042_RS03100	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AA042_RS03130	COG0438	transferase activity, transferring glycosyl groups
AA042_RS03150	COG0728	peptidoglycan biosynthetic process
AA042_RS03160	COG0303	'Molybdopterin
AA042_RS03165	COG0521	Mo-molybdopterin cofactor biosynthetic process
AA042_RS03170	COG0746	molybdenum cofactor guanylyltransferase activity
AA042_RS03180	COG0564	pseudouridine synthase activity
AA042_RS03195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
AA042_RS03225	COG2197	response regulator
AA042_RS03235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AA042_RS03240	COG1956	GAF domain-containing protein
AA042_RS03250	COG0784	Response regulator, receiver
AA042_RS03250	COG2205	protein histidine kinase activity
AA042_RS03250	COG5002	protein histidine kinase activity
AA042_RS03255	COG0386	Belongs to the glutathione peroxidase family
AA042_RS03260	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA042_RS03265	COG0436	Aminotransferase
AA042_RS03270	COG0501	Belongs to the peptidase M48B family
AA042_RS03275	COG0500	methyltransferase
AA042_RS03285	COG0513	Belongs to the DEAD box helicase family
AA042_RS03300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AA042_RS03310	COG0583	DNA-binding transcription factor activity
AA042_RS03320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AA042_RS03335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA042_RS03350	COG2814	Major facilitator Superfamily
AA042_RS03405	COG0204	Acyl-transferase
AA042_RS03410	COG0598	Magnesium transport protein CorA
AA042_RS03415	COG0519	Catalyzes the synthesis of GMP from XMP
AA042_RS03455	COG2885	chlorophyll binding
AA042_RS03455	COG3047	cAMP biosynthetic process
AA042_RS03485	COG2207	Transcriptional regulator
AA042_RS03490	COG1064	alcohol dehydrogenase
AA042_RS03515	COG0084	hydrolase, TatD family'
AA042_RS03525	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AA042_RS03530	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AA042_RS03540	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA042_RS03545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA042_RS03555	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AA042_RS03560	COG0416	fatty acid biosynthetic process
AA042_RS03565	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AA042_RS03575	COG0424	maF-like protein
AA042_RS03580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA042_RS03580	COG0616	signal peptide processing
AA042_RS03585	COG0546	phosphoglycolate phosphatase activity
AA042_RS03595	COG1530	ribonuclease E activity
AA042_RS03605	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AA042_RS03610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AA042_RS03620	COG2835	tetraacyldisaccharide 4'-kinase activity
AA042_RS03625	COG1663	tetraacyldisaccharide 4'-kinase activity
AA042_RS03635	COG0811	peptide transport
AA042_RS03650	COG0842	Transport permease protein
AA042_RS03655	COG1131	(ABC) transporter
AA042_RS03660	COG0625	glutathione transferase activity
AA042_RS03680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA042_RS03690	COG4175	Glycine betaine
AA042_RS03695	COG4176	ABC-type proline glycine betaine transport system permease component
AA042_RS03740	COG3171	Protein conserved in bacteria
AA042_RS03745	COG2027	D-alanyl-D-alanine carboxypeptidase
AA042_RS03750	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA042_RS03750	COG0116	Belongs to the methyltransferase superfamily
AA042_RS03760	COG3130	regulation of translation
AA042_RS03765	COG0167	dihydroorotate dehydrogenase activity
AA042_RS03770	COG2885	chlorophyll binding
AA042_RS03770	COG3047	cAMP biosynthetic process
AA042_RS03780	COG0668	transmembrane transport
AA042_RS03795	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA042_RS03810	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
AA042_RS03815	COG2079	MmgE PrpD family protein
AA042_RS03830	COG0372	Belongs to the citrate synthase family
AA042_RS03840	COG1802	Transcriptional regulator
AA042_RS03845	COG4067	protein conserved in archaea
AA042_RS03845	COG0189	ligase activity
AA042_RS03870	COG1595	DNA-templated transcription, initiation
AA042_RS03905	COG2974	May be involved in recombination
AA042_RS03910	COG2076	Multidrug Resistance protein
AA042_RS03925	COG2205	protein histidine kinase activity
AA042_RS03970	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AA042_RS03980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
AA042_RS03990	COG1492	cobalamin metabolic process
AA042_RS04005	COG0778	Nitroreductase
AA042_RS04010	COG1797	cobyrinic acid a,c-diamide synthase activity
AA042_RS04025	COG0791	NLP P60 protein
AA042_RS04030	COG0791	NLP P60 protein
AA042_RS04035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA042_RS04040	COG0628	permease
AA042_RS04050	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AA042_RS04055	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AA042_RS04070	COG3122	Protein conserved in bacteria
AA042_RS04075	COG3956	TIGRFAM MazG family protein
AA042_RS04080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA042_RS04085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA042_RS04105	COG0784	Response regulator, receiver
AA042_RS04105	COG2205	protein histidine kinase activity
AA042_RS04105	COG5002	protein histidine kinase activity
AA042_RS04110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA042_RS04125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AA042_RS04130	COG1393	Belongs to the ArsC family
AA042_RS04145	COG2818	Glycosylase
AA042_RS04150	COG0037	tRNA processing
AA042_RS04160	COG3091	SprT-like family
AA042_RS04200	COG3209	COG3209 Rhs family protein
AA042_RS04215	COG1301	dicarboxylic acid transport
AA042_RS04225	COG0745	RESPONSE REGULATOR receiver
AA042_RS04250	COG4191	Histidine kinase
AA042_RS04260	COG0477	Major facilitator Superfamily
AA042_RS04295	COG2207	Transcriptional regulator
AA042_RS04300	COG2910	NAD(P)H-binding
AA042_RS04310	COG0583	DNA-binding transcription factor activity
AA042_RS04315	COG0477	Major facilitator Superfamily
AA042_RS04325	COG1090	epimerase
AA042_RS04330	COG0583	DNA-binding transcription factor activity
AA042_RS04340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AA042_RS04375	COG3642	lipopolysaccharide core region biosynthetic process
AA042_RS04385	COG0642	Histidine kinase
AA042_RS04395	COG1368	sulfuric ester hydrolase activity
AA042_RS04410	COG0459	protein refolding
AA042_RS04415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AA042_RS04420	COG3030	protein affecting phage T7 exclusion by the F plasmid
AA042_RS04430	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS04440	COG3695	enzyme binding
AA042_RS04445	COG2211	Major facilitator Superfamily
AA042_RS04450	COG0442	prolyl-tRNA aminoacylation
AA042_RS04460	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AA042_RS04490	COG3158	transport of potassium into the cell
AA042_RS04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA042_RS04505	COG0519	Catalyzes the synthesis of GMP from XMP
AA042_RS04510	COG1187	pseudouridine synthase activity
AA042_RS04515	COG4807	Protein conserved in bacteria
AA042_RS04530	COG0583	DNA-binding transcription factor activity
AA042_RS04555	COG1611	Belongs to the LOG family
AA042_RS04560	COG2137	regulation of response to DNA damage stimulus
AA042_RS04565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AA042_RS04570	COG1546	Belongs to the CinA family
AA042_RS04585	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AA042_RS04590	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
AA042_RS04605	COG1309	transcriptional regulator
AA042_RS04610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS04630	COG0306	phosphate transporter
AA042_RS04640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AA042_RS04710	COG3220	belongs to the UPF0276 family
AA042_RS04725	COG0583	DNA-binding transcription factor activity
AA042_RS04740	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AA042_RS04745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AA042_RS04760	COG0259	pyridoxamine-phosphate oxidase activity
AA042_RS04780	COG1199	ATP-dependent helicase activity
AA042_RS04805	COG3012	SEC-C Motif Domain Protein
AA042_RS04815	COG0653	protein targeting
AA042_RS04820	COG0625	glutathione transferase activity
AA042_RS04825	COG2366	antibiotic biosynthetic process
AA042_RS04835	COG1793	dna ligase
AA042_RS04845	COG1201	RNA secondary structure unwinding
AA042_RS04860	COG0717	Belongs to the dCTP deaminase family
AA042_RS04865	COG1278	Cold shock
AA042_RS04870	COG0489	protein tyrosine kinase activity
AA042_RS04875	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA042_RS04875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AA042_RS04880	COG2878	Part of a membrane complex involved in electron transport
AA042_RS04885	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AA042_RS04895	COG2197	response regulator
AA042_RS04905	COG0137	argininosuccinate synthase activity
AA042_RS04915	COG0418	dihydroorotase activity
AA042_RS04920	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA042_RS04925	COG0450	alkyl hydroperoxide reductase
AA042_RS04940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
AA042_RS04945	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AA042_RS04955	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA042_RS04965	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AA042_RS04990	COG0765	amino acid transport
AA042_RS04995	COG1126	abc transporter atp-binding protein
AA042_RS05025	COG2076	Multidrug Resistance protein
AA042_RS05040	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA042_RS05055	COG4191	Histidine kinase
AA042_RS05065	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
AA042_RS05070	COG0583	DNA-binding transcription factor activity
AA042_RS05085	COG0494	nUDIX hydrolase
AA042_RS05090	COG0069	glutamate synthase activity
AA042_RS05105	COG1113	amino acid transport
AA042_RS05115	COG1695	Transcriptional regulator
AA042_RS05120	COG2375	cellular response to nickel ion
AA042_RS05130	COG4628	conserved protein (DUF2132)
AA042_RS05135	COG4206	TonB-dependent receptor
AA042_RS05170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA042_RS05195	COG2226	methyltransferase
AA042_RS05225	COG4580	involved in the transport of maltose and maltodextrins
AA042_RS05230	COG0366	Alpha amylase catalytic
AA042_RS05235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
AA042_RS05235	COG1263	PTS System
AA042_RS05240	COG2188	Transcriptional regulator
AA042_RS05255	COG1304	FMN binding
AA042_RS05260	COG0583	DNA-binding transcription factor activity
AA042_RS05310	COG0582	viral genome integration into host DNA
AA042_RS05315	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AA042_RS05315	COG0519	Catalyzes the synthesis of GMP from XMP
AA042_RS05335	COG1570	exodeoxyribonuclease VII activity
AA042_RS05340	COG0739	heme binding
AA042_RS05345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AA042_RS05350	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA042_RS05355	COG0436	Aminotransferase
AA042_RS05360	COG1160	GTP binding
AA042_RS05375	COG0124	histidyl-tRNA synthetase
AA042_RS05380	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AA042_RS05395	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AA042_RS05400	COG0105	UTP biosynthetic process
AA042_RS05410	COG0633	Ferredoxin
AA042_RS05415	COG0443	Heat shock 70 kDa protein
AA042_RS05420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA042_RS05425	COG0316	Belongs to the HesB IscA family
AA042_RS05435	COG1104	cysteine desulfurase activity
AA042_RS05445	COG1045	serine acetyltransferase
AA042_RS05460	COG3134	Outer membrane lipoprotein
AA042_RS05475	COG1862	Preprotein translocase
AA042_RS05480	COG0343	queuine tRNA-ribosyltransferase activity
AA042_RS05485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
AA042_RS05540	COG0706	membrane insertase activity
AA042_RS05555	COG1213	nucleotidyl transferase
AA042_RS05560	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA042_RS05565	COG3848	Pyruvate phosphate dikinase
AA042_RS05565	COG0574	Belongs to the PEP-utilizing enzyme family
AA042_RS05585	COG0109	protoheme IX farnesyltransferase activity
AA042_RS05595	COG1845	cytochrome c oxidase, subunit III
AA042_RS05600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AA042_RS05605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA042_RS05610	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AA042_RS05615	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA042_RS05615	COG1017	nitric oxide dioxygenase activity
AA042_RS05625	COG0784	Response regulator, receiver
AA042_RS05625	COG0835	chemotaxis
AA042_RS05670	COG3706	GGDEF domain
AA042_RS05670	COG4251	negative regulation of phosphorylation
AA042_RS05670	COG5001	Diguanylate cyclase
AA042_RS05670	COG2203	Gaf domain
AA042_RS05675	COG3706	GGDEF domain
AA042_RS05675	COG5001	Diguanylate cyclase
AA042_RS05675	COG2203	Gaf domain
AA042_RS05675	COG4251	negative regulation of phosphorylation
AA042_RS05680	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AA042_RS05685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AA042_RS05700	COG1181	Belongs to the D-alanine--D-alanine ligase family
AA042_RS05705	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA042_RS05710	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AA042_RS05720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AA042_RS05730	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AA042_RS05735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AA042_RS05750	COG0275	rRNA processing
AA042_RS05755	COG2001	Belongs to the MraZ family
AA042_RS05775	COG0792	nuclease activity
AA042_RS05780	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AA042_RS05785	COG2823	Periplasmic or secreted lipoprotein
AA042_RS05790	COG2969	positive regulation of protein catabolic process
AA042_RS05795	COG0625	glutathione transferase activity
AA042_RS05800	COG2857	Cytochrome c1
AA042_RS05805	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AA042_RS05815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AA042_RS05820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AA042_RS05825	COG0667	Aldo Keto reductase
AA042_RS05835	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AA042_RS05840	COG0180	Tryptophanyl-tRNA synthetase
AA042_RS05855	COG2885	chlorophyll binding
AA042_RS05860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AA042_RS05870	COG0318	PFAM AMP-dependent synthetase and ligase
AA042_RS05875	COG1280	lysine exporter protein (LysE YggA)
AA042_RS05880	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AA042_RS05885	COG2813	Specifically methylates the guanine in position
AA042_RS05890	COG2119	membrane
AA042_RS05895	COG0501	Belongs to the peptidase M48B family
AA042_RS05900	COG2135	peptidase activity
AA042_RS05960	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
AA042_RS05965	COG3852	Histidine kinase
AA042_RS05975	COG0747	negative chemotaxis
AA042_RS05980	COG0747	negative chemotaxis
AA042_RS05990	COG0747	negative chemotaxis
AA042_RS05995	COG0601	transmembrane transport
AA042_RS06000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA042_RS06005	COG0444	Belongs to the ABC transporter superfamily
AA042_RS06025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
AA042_RS06050	COG0019	diaminopimelate decarboxylase activity
AA042_RS06080	COG3128	pkhd-type hydroxylase
AA042_RS06085	COG4774	siderophore transport
AA042_RS06105	COG1105	Belongs to the carbohydrate kinase PfkB family
AA042_RS06115	COG1609	Transcriptional regulator
AA042_RS06120	COG0084	hydrolase, TatD family'
AA042_RS06145	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AA042_RS06200	COG4974	Belongs to the 'phage' integrase family
AA042_RS06220	COG0582	viral genome integration into host DNA
AA042_RS06245	COG0237	dephospho-CoA kinase activity
AA042_RS06250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
AA042_RS06275	COG1252	NADH dehydrogenase
AA042_RS06280	COG0076	glutamate decarboxylase activity
AA042_RS06285	COG2066	Belongs to the glutaminase family
AA042_RS06290	COG0531	amino acid
AA042_RS06315	COG0542	response to heat
AA042_RS06340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS06370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AA042_RS06375	COG1047	Peptidyl-prolyl cis-trans
AA042_RS06380	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AA042_RS06385	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AA042_RS06390	COG0196	riboflavin kinase activity
AA042_RS06395	COG0728	peptidoglycan biosynthetic process
AA042_RS06405	COG0268	Binds directly to 16S ribosomal RNA
AA042_RS06410	COG3045	CreA protein
AA042_RS06420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AA042_RS06425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AA042_RS06430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AA042_RS06435	COG0142	geranyltranstransferase activity
AA042_RS06440	COG2824	Alkylphosphonate utilization operon protein PhnA
AA042_RS06445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA042_RS06450	COG0545	Peptidyl-prolyl cis-trans isomerase
AA042_RS06455	COG2862	Uncharacterized protein family, UPF0114
AA042_RS06470	COG1067	ATP-dependent peptidase activity
AA042_RS06505	COG0488	(ABC) transporter
AA042_RS06515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA042_RS06520	COG0523	cobalamin synthesis protein
AA042_RS06525	COG2879	small protein
AA042_RS06530	COG1966	Carbon starvation protein
AA042_RS06555	COG1970	mechanosensitive ion channel activity
AA042_RS06565	COG2197	response regulator
AA042_RS06570	COG2813	Specifically methylates the guanine in position
AA042_RS06580	COG1294	oxidase, subunit
AA042_RS06585	COG1271	oxidase subunit
AA042_RS06600	COG2252	PERMEase
AA042_RS06605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AA042_RS06645	COG2321	neutral zinc metallopeptidase
AA042_RS06655	COG1946	Acyl-CoA thioesterase
AA042_RS06665	COG0123	including yeast histone deacetylase and acetoin utilization protein
AA042_RS06675	COG0513	Belongs to the DEAD box helicase family
AA042_RS06680	COG0697	spore germination
AA042_RS06730	COG1643	Atp-dependent helicase
AA042_RS06750	COG1522	sequence-specific DNA binding
AA042_RS06765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AA042_RS06770	COG1960	acyl-CoA dehydrogenase activity
AA042_RS06780	COG0351	phosphomethylpyrimidine kinase
AA042_RS06785	COG0352	thiamine-phosphate diphosphorylase activity
AA042_RS06790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AA042_RS06805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AA042_RS06810	COG1702	phosphate starvation-inducible protein PhoH
AA042_RS06815	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AA042_RS06820	COG4535	Mg2 and Co2 transporter CorC
AA042_RS06825	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AA042_RS06840	COG0495	leucyl-tRNA aminoacylation
AA042_RS06860	COG2951	lytic endotransglycosylase activity
AA042_RS06865	COG1619	proteins homologs of microcin C7 resistance protein MccF
AA042_RS06870	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AA042_RS06875	COG0321	lipoyl(octanoyl) transferase activity
AA042_RS06880	COG2921	Belongs to the UPF0250 family
AA042_RS06885	COG1686	Belongs to the peptidase S11 family
AA042_RS06900	COG0772	Belongs to the SEDS family
AA042_RS06905	COG0768	penicillin binding
AA042_RS06910	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
AA042_RS06920	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AA042_RS06925	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AA042_RS06930	COG2094	Belongs to the DNA glycosylase MPG family
AA042_RS06935	COG0586	Pfam SNARE associated Golgi protein
AA042_RS06945	COG1346	cytolysis
AA042_RS06960	COG0702	epimerase
AA042_RS06975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AA042_RS06990	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS06995	COG0531	amino acid
AA042_RS07000	COG4303	Ethanolamine ammonia lyase large subunit
AA042_RS07005	COG4302	ethanolamine ammonia-lyase activity
AA042_RS07010	COG0586	Pfam SNARE associated Golgi protein
AA042_RS07020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AA042_RS07065	COG5377	YqaJ viral recombinase family
AA042_RS07075	COG2003	Belongs to the UPF0758 family
AA042_RS07160	COG0631	protein serine/threonine phosphatase activity
AA042_RS07235	COG1722	exodeoxyribonuclease VII activity
AA042_RS07240	COG0142	geranyltranstransferase activity
AA042_RS07245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AA042_RS07250	COG4206	TonB-dependent receptor
AA042_RS07255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AA042_RS07265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA042_RS07270	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AA042_RS07275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AA042_RS07280	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA042_RS07295	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA042_RS07295	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA042_RS07300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA042_RS07315	COG3118	belongs to the thioredoxin family
AA042_RS07330	COG1136	(ABC) transporter
AA042_RS07345	COG3047	cAMP biosynthetic process
AA042_RS07350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AA042_RS07360	COG0668	transmembrane transport
AA042_RS07365	COG0583	DNA-binding transcription factor activity
AA042_RS07370	COG2814	Major facilitator Superfamily
AA042_RS07385	COG2828	Protein conserved in bacteria
AA042_RS07390	COG0583	DNA-binding transcription factor activity
AA042_RS07395	COG0629	single-stranded DNA binding
AA042_RS07400	COG2814	Major facilitator Superfamily
AA042_RS07410	COG2193	ferroxidase activity
AA042_RS07420	COG0203	ribosomal protein L17
AA042_RS07425	COG0202	RNA polymerase activity
AA042_RS07430	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AA042_RS07435	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AA042_RS07440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AA042_RS07445	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AA042_RS07455	COG0200	Binds to the 23S rRNA
AA042_RS07460	COG1841	ribosomal large subunit assembly
AA042_RS07465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AA042_RS07470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AA042_RS07475	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AA042_RS07480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AA042_RS07485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AA042_RS07490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AA042_RS07495	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AA042_RS07500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AA042_RS07505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AA042_RS07510	COG0255	Belongs to the universal ribosomal protein uL29 family
AA042_RS07515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AA042_RS07520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AA042_RS07525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AA042_RS07530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AA042_RS07535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AA042_RS07540	COG0089	rRNA binding
AA042_RS07545	COG0088	Forms part of the polypeptide exit tunnel
AA042_RS07550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AA042_RS07555	COG0051	transcription antitermination factor activity, RNA binding
AA042_RS07560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AA042_RS07565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AA042_RS07570	COG0049	tRNA binding
AA042_RS07575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AA042_RS07580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AA042_RS07585	COG0085	RNA polymerase activity
AA042_RS07590	COG0222	ribosome binding
AA042_RS07595	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AA042_RS07600	COG0081	regulation of translation
AA042_RS07605	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AA042_RS07645	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AA042_RS07685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AA042_RS07690	COG0739	heme binding
AA042_RS07695	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
AA042_RS07700	COG0316	Belongs to the HesB IscA family
AA042_RS07705	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AA042_RS07725	COG4221	oxidoreductase activity
AA042_RS07730	COG0537	adenosine 5'-monophosphoramidase activity
AA042_RS07735	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
AA042_RS07740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AA042_RS07745	COG1765	OsmC-like protein
AA042_RS07760	COG0134	indole-3-glycerol-phosphate synthase activity
AA042_RS07765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA042_RS07770	COG0512	Glutamine amidotransferase of anthranilate synthase
AA042_RS07780	COG0546	phosphoglycolate phosphatase activity
AA042_RS07785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AA042_RS07810	COG3842	ATPase activity
AA042_RS07815	COG2197	response regulator
AA042_RS07820	COG4585	Histidine kinase
AA042_RS07830	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AA042_RS07845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AA042_RS07850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA042_RS07855	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AA042_RS07860	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AA042_RS07865	COG2967	ApaG domain
AA042_RS07870	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA042_RS07875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA042_RS07880	COG2766	serine protein kinase
AA042_RS07885	COG2718	Belongs to the UPF0229 family
AA042_RS07890	COG2719	SpoVR family
AA042_RS07895	COG0617	tRNA 3'-terminal CCA addition
AA042_RS07910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AA042_RS07915	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AA042_RS07920	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AA042_RS07925	COG0358	DNA primase activity
AA042_RS07930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AA042_RS07955	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA042_RS07960	COG1025	Belongs to the peptidase M16 family
AA042_RS07970	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
AA042_RS07985	COG0535	radical SAM domain protein
AA042_RS08000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AA042_RS08005	COG0583	DNA-binding transcription factor activity
AA042_RS08010	COG1960	acyl-CoA dehydrogenase activity
AA042_RS08015	COG3706	GGDEF domain
AA042_RS08020	COG1960	acyl-CoA dehydrogenase activity
AA042_RS08045	COG0156	8-amino-7-oxononanoate synthase activity
AA042_RS08055	COG1040	competence protein
AA042_RS08060	COG3585	molybdate ion transport
AA042_RS08060	COG2005	Transcriptional regulator
AA042_RS08070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
AA042_RS08085	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
AA042_RS08100	COG2176	DNA-directed DNA polymerase activity
AA042_RS08105	COG1595	DNA-templated transcription, initiation
AA042_RS08140	COG0189	ligase activity
AA042_RS08140	COG4067	protein conserved in archaea
AA042_RS08145	COG0204	Acyl-transferase
AA042_RS08200	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AA042_RS08230	COG4638	Rieske (2fe-2S)
AA042_RS08245	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AA042_RS08250	COG2181	nitrate reductase activity
AA042_RS08250	COG0247	lactate metabolic process
AA042_RS08255	COG1902	pentaerythritol trinitrate reductase activity
AA042_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA042_RS08315	COG3039	Transposase
AA042_RS08335	COG1760	l-serine dehydratase
AA042_RS08345	COG4176	ABC-type proline glycine betaine transport system permease component
AA042_RS08350	COG4175	Glycine betaine
AA042_RS08355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AA042_RS08360	COG1309	transcriptional regulator
AA042_RS08365	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS08370	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
AA042_RS08375	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AA042_RS08390	COG0477	Major facilitator Superfamily
AA042_RS08395	COG0513	Belongs to the DEAD box helicase family
AA042_RS08400	COG2081	HI0933 family
AA042_RS08405	COG1289	transmembrane transporter activity
AA042_RS08415	COG2153	protein acetylation
AA042_RS08425	COG1451	nucleotide metabolic process
AA042_RS08440	COG1858	cytochrome C peroxidase
AA042_RS08460	COG1595	DNA-templated transcription, initiation
AA042_RS08475	COG0126	phosphoglycerate kinase activity
AA042_RS08480	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AA042_RS08485	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AA042_RS08490	COG0640	Transcriptional regulator
AA042_RS08495	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AA042_RS08525	COG0251	oxidation-reduction process
AA042_RS08540	COG4993	Dehydrogenase
AA042_RS08555	COG4792	protein secretion
AA042_RS08560	COG4791	protein targeting
AA042_RS08565	COG4794	Type iii secretion
AA042_RS08570	COG4790	Type iii secretion
AA042_RS08730	COG1317	bacterial-type flagellum organization
AA042_RS08755	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AA042_RS08765	COG3038	cytochrome b561
AA042_RS08770	COG2353	YceI-like domain
AA042_RS08775	COG0513	Belongs to the DEAD box helicase family
AA042_RS08780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AA042_RS08785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AA042_RS08795	COG2116	formate transmembrane transporter activity
AA042_RS08800	COG1272	protein, Hemolysin III
AA042_RS08855	COG0189	ligase activity
AA042_RS08865	COG1678	Uncharacterized ACR, COG1678
AA042_RS08870	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AA042_RS08875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AA042_RS08880	COG0540	Belongs to the ATCase OTCase family
AA042_RS08885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AA042_RS08900	COG0791	NLP P60 protein
AA042_RS08925	COG1872	DUF167
AA042_RS08930	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA042_RS08935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA042_RS08935	COG2813	Specifically methylates the guanine in position
AA042_RS08945	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AA042_RS08950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AA042_RS08965	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AA042_RS08970	COG2022	thiamine diphosphate biosynthetic process
AA042_RS08980	COG2363	Small membrane protein
AA042_RS08985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA042_RS08995	COG2177	Part of the ABC transporter FtsEX involved in
AA042_RS09000	COG2884	Cell division ATP-binding protein ftsE
AA042_RS09005	COG0552	protein localization to endoplasmic reticulum
AA042_RS09010	COG0612	Peptidase, M16
AA042_RS09015	COG0612	Peptidase, M16
AA042_RS09020	COG0742	ribosomal rna small subunit methyltransferase
AA042_RS09025	COG0612	Peptidase, M16
AA042_RS09030	COG0612	Peptidase, M16
AA042_RS09045	COG0612	Peptidase, M16
AA042_RS09070	COG1309	transcriptional regulator
AA042_RS09090	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AA042_RS09095	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AA042_RS09100	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AA042_RS09110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA042_RS09135	COG0129	dihydroxy-acid dehydratase activity
AA042_RS09170	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA042_RS09180	COG1840	ABC-type Fe3 transport system, periplasmic component
AA042_RS09185	COG1178	ABC-type Fe3 transport system permease component
AA042_RS09190	COG3842	ATPase activity
AA042_RS09195	COG0583	DNA-binding transcription factor activity
AA042_RS09205	COG0789	Transcriptional regulator
AA042_RS09215	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
AA042_RS09220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AA042_RS09225	COG0730	response to heat
AA042_RS09240	COG0494	nUDIX hydrolase
AA042_RS09255	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AA042_RS09260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
AA042_RS09270	COG3360	Dodecin
AA042_RS09285	COG0133	tryptophan synthase activity
AA042_RS09290	COG0159	tryptophan synthase activity
AA042_RS09295	COG2011	ABC-type metal ion transport system permease component
AA042_RS09330	COG3204	pilus organization
AA042_RS09335	COG3204	pilus organization
AA042_RS09350	COG0174	glutamine synthetase
AA042_RS09355	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AA042_RS09360	COG0174	glutamine synthetase
AA042_RS09380	COG3842	ATPase activity
AA042_RS09385	COG1176	ABC-type spermidine putrescine transport system, permease component I
AA042_RS09390	COG1177	transmembrane transport
AA042_RS09410	COG1253	flavin adenine dinucleotide binding
AA042_RS09415	COG2851	Citrate transporter
AA042_RS09420	COG1283	sodium-dependent phosphate transmembrane transporter activity
AA042_RS09425	COG0612	Peptidase, M16
AA042_RS09430	COG1045	serine acetyltransferase
AA042_RS09440	COG1116	anion transmembrane transporter activity
AA042_RS09445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA042_RS09450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA042_RS09460	COG0431	NADPH-dependent FMN reductase
AA042_RS09465	COG0450	alkyl hydroperoxide reductase
AA042_RS09475	COG4521	taurine ABC transporter
AA042_RS09480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
AA042_RS09485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA042_RS09490	COG2175	clavaminate synthase activity
AA042_RS09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AA042_RS09510	COG1764	response to oxidative stress
AA042_RS09565	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AA042_RS09575	COG0277	FAD linked oxidase domain protein
AA042_RS09580	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA042_RS09590	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA042_RS09595	COG1127	ABC transporter
AA042_RS09610	COG0700	Nucleoside recognition
AA042_RS09615	COG1301	dicarboxylic acid transport
AA042_RS09635	COG2204	response regulator
AA042_RS09640	COG5002	protein histidine kinase activity
AA042_RS09645	COG4943	cyclic-guanylate-specific phosphodiesterase activity
AA042_RS09650	COG3023	N-Acetylmuramoyl-L-alanine amidase
AA042_RS09665	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
AA042_RS09680	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AA042_RS09715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AA042_RS09730	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AA042_RS09755	COG1612	heme a metabolic process
AA042_RS09775	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
AA042_RS09785	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AA042_RS09835	COG3161	chorismate lyase activity
AA042_RS09865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AA042_RS09870	COG0583	DNA-binding transcription factor activity
AA042_RS09880	COG0848	biopolymer transport protein
AA042_RS09905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AA042_RS09910	COG1758	RNA polymerase activity
AA042_RS09915	COG0194	GDP metabolic process
AA042_RS09920	COG1561	YicC-like family, N-terminal region
AA042_RS09925	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AA042_RS09940	COG0708	Exodeoxyribonuclease III
AA042_RS09945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AA042_RS09950	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA042_RS09955	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA042_RS09965	COG0756	dUTP diphosphatase activity
AA042_RS09970	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AA042_RS09975	COG2003	Belongs to the UPF0758 family
AA042_RS09980	COG0747	negative chemotaxis
AA042_RS09985	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AA042_RS09990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AA042_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS10025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA042_RS10030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS10040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS10055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS10065	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AA042_RS10085	COG0427	acetyl-CoA hydrolase
AA042_RS10090	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AA042_RS10110	COG0583	DNA-binding transcription factor activity
AA042_RS10130	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA042_RS10140	COG1136	(ABC) transporter
AA042_RS10180	COG0347	Belongs to the P(II) protein family
AA042_RS10185	COG0004	ammonium transporteR
AA042_RS10195	COG1011	Hydrolase
AA042_RS10200	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
AA042_RS10210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AA042_RS10215	COG0019	diaminopimelate decarboxylase activity
AA042_RS10230	COG1965	Belongs to the frataxin family
AA042_RS10240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA042_RS10260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA042_RS10270	COG4208	sulfate ABC transporter
AA042_RS10275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AA042_RS10290	COG4589	Belongs to the CDS family
AA042_RS10295	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
AA042_RS10300	COG0339	signal peptide processing
AA042_RS10305	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AA042_RS10325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
AA042_RS10330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
AA042_RS10380	COG3829	transcription factor binding
AA042_RS10400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS10405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA042_RS10415	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
AA042_RS10425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AA042_RS10430	COG0408	coproporphyrinogen oxidase activity
AA042_RS10440	COG0009	L-threonylcarbamoyladenylate synthase
AA042_RS10445	COG0758	DNA mediated transformation
AA042_RS10450	COG0242	peptide deformylase activity
AA042_RS10455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AA042_RS10460	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AA042_RS10465	COG0569	domain protein
AA042_RS10480	COG2818	Glycosylase
AA042_RS10485	COG0752	glycyl-tRNA synthetase alpha subunit
AA042_RS10490	COG0751	glycine-tRNA ligase activity
AA042_RS10495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AA042_RS10530	COG0187	DNA topoisomerase II activity
AA042_RS10535	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AA042_RS10540	COG0592	DNA-directed DNA polymerase activity
AA042_RS10545	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AA042_RS10550	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AA042_RS10555	COG0594	ribonuclease P activity
AA042_RS10560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AA042_RS10565	COG0706	membrane insertase activity
AA042_RS10570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AA042_RS10575	COG0488	(ABC) transporter
AA042_RS10580	COG0445	tRNA wobble uridine modification
AA042_RS10585	COG0357	Ribosomal RNA small subunit methyltransferase G
AA042_RS10590	COG1192	Involved in chromosome partitioning
AA042_RS10595	COG1475	DNA binding
AA042_RS10600	COG3312	ion transport
AA042_RS10605	COG0356	it plays a direct role in the translocation of protons across the membrane
AA042_RS10615	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AA042_RS10620	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AA042_RS10625	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AA042_RS10630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AA042_RS10635	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AA042_RS10640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AA042_RS10645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AA042_RS10650	COG1349	DNA-binding transcription factor activity
AA042_RS10655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AA042_RS10670	COG1401	restriction endodeoxyribonuclease activity
AA042_RS10700	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA042_RS10710	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA042_RS10715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA042_RS10725	COG1469	GTP cyclohydrolase I activity
AA042_RS10740	COG0523	cobalamin synthesis protein
AA042_RS10750	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
AA042_RS10755	COG1607	acyl-coa hydrolase
AA042_RS10760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA042_RS10760	COG4651	solute:proton antiporter activity
AA042_RS10780	COG0210	DNA helicase
AA042_RS10800	COG0583	DNA-binding transcription factor activity
AA042_RS10805	COG0439	Biotin carboxylase
AA042_RS10810	COG5016	pyruvate
AA042_RS10810	COG0511	ligase activity, forming carbon-carbon bonds
AA042_RS10865	COG0252	asparaginase activity
AA042_RS10880	COG1027	Aspartate ammonia-lyase
AA042_RS10885	COG0583	DNA-binding transcription factor activity
AA042_RS10920	COG1607	acyl-coa hydrolase
AA042_RS10925	COG0477	Major facilitator Superfamily
AA042_RS10940	COG0573	inorganic phosphate transmembrane transporter activity
AA042_RS10945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AA042_RS10950	COG0704	Plays a role in the regulation of phosphate uptake
AA042_RS10985	COG0427	acetyl-CoA hydrolase
AA042_RS11005	COG0583	DNA-binding transcription factor activity
AA042_RS11010	COG1960	acyl-CoA dehydrogenase activity
AA042_RS11015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA042_RS11085	COG0840	transmembrane signaling receptor activity
AA042_RS11090	COG1802	Transcriptional regulator
AA042_RS11115	COG1566	PFAM secretion protein HlyD family protein
AA042_RS11155	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS11160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AA042_RS11165	COG0745	RESPONSE REGULATOR receiver
AA042_RS11190	COG0165	Argininosuccinate lyase
AA042_RS11200	COG0181	hydroxymethylbilane synthase activity
AA042_RS11250	COG0488	(ABC) transporter
AA042_RS11260	COG1280	lysine exporter protein (LysE YggA)
AA042_RS11265	COG0672	)-iron permease
AA042_RS11270	COG1671	Belongs to the UPF0178 family
AA042_RS11275	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
AA042_RS11280	COG0586	Pfam SNARE associated Golgi protein
AA042_RS11290	COG0248	Ppx GppA phosphatase
AA042_RS11310	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AA042_RS11315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
AA042_RS11315	COG0543	2 iron, 2 sulfur cluster binding
AA042_RS11330	COG2271	Major facilitator Superfamily
AA042_RS11350	COG0842	Transport permease protein
AA042_RS11355	COG1129	ABC transporter
AA042_RS11355	COG0842	Transport permease protein
AA042_RS11360	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS11370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AA042_RS11390	COG3079	Belongs to the UPF0149 family
AA042_RS11395	COG0006	proline dipeptidase activity
AA042_RS11400	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA042_RS11405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
AA042_RS11415	COG1178	ABC-type Fe3 transport system permease component
AA042_RS11420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA042_RS11425	COG0509	glycine decarboxylation via glycine cleavage system
AA042_RS11430	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AA042_RS11440	COG1585	Membrane protein implicated in regulation of membrane protease activity
AA042_RS11445	COG0330	HflC and HflK could
AA042_RS11460	COG1522	sequence-specific DNA binding
AA042_RS11490	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AA042_RS11500	COG1652	LysM domain
AA042_RS11505	COG1011	Hydrolase
AA042_RS11510	COG0494	nUDIX hydrolase
AA042_RS11515	COG1218	3'(2'),5'-bisphosphate nucleotidase
AA042_RS11545	COG2957	Belongs to the agmatine deiminase family
AA042_RS11600	COG2351	hydroxyisourate hydrolase activity
AA042_RS11615	COG4215	(ABC) transporter
AA042_RS11620	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA042_RS11640	COG0010	Belongs to the arginase family
AA042_RS11645	COG0786	glutamate:sodium symporter activity
AA042_RS11650	COG4251	negative regulation of phosphorylation
AA042_RS11660	COG3813	Protein conserved in bacteria
AA042_RS11665	COG0640	Transcriptional regulator
AA042_RS11670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AA042_RS11700	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
AA042_RS11705	COG1194	a g-specific adenine glycosylase
AA042_RS11715	COG2223	nitrite transmembrane transporter activity
AA042_RS11720	COG0131	Imidazoleglycerol-phosphate dehydratase
AA042_RS11725	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AA042_RS11735	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AA042_RS11740	COG0107	imidazoleglycerol-phosphate synthase activity
AA042_RS11750	COG2861	carbohydrate metabolic process
AA042_RS11755	COG0793	Belongs to the peptidase S41A family
AA042_RS11765	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
AA042_RS11780	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
AA042_RS11800	COG3852	Histidine kinase
AA042_RS11825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AA042_RS11825	COG0301	tRNA thio-modification
AA042_RS11840	COG0058	SHG alpha-glucan phosphorylase activity
AA042_RS11845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
AA042_RS11855	COG3040	lipid binding
AA042_RS11870	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AA042_RS11870	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AA042_RS11880	COG2918	glutathione biosynthetic process
AA042_RS11890	COG2183	response to ionizing radiation
AA042_RS11895	COG0745	RESPONSE REGULATOR receiver
AA042_RS11905	COG0189	ligase activity
AA042_RS11910	COG4067	protein conserved in archaea
AA042_RS11910	COG0189	ligase activity
AA042_RS11915	COG2199	diguanylate cyclase activity
AA042_RS11915	COG3287	FIST C domain
AA042_RS11915	COG2200	EAL domain
AA042_RS11920	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AA042_RS11930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AA042_RS11940	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AA042_RS11950	COG0514	ATP-dependent DNA helicase (RecQ)
AA042_RS11965	COG2188	Transcriptional regulator
AA042_RS11975	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
AA042_RS11980	COG2986	histidine ammonia-lyase
AA042_RS11990	COG1228	amidohydrolase
AA042_RS12005	COG1490	D-aminoacyl-tRNA deacylase activity
AA042_RS12010	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
AA042_RS12015	COG2943	transferase activity, transferring hexosyl groups
AA042_RS12025	COG0765	amino acid transport
AA042_RS12035	COG0840	transmembrane signaling receptor activity
AA042_RS12040	COG0840	transmembrane signaling receptor activity
AA042_RS12060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AA042_RS12065	COG0140	phosphoribosyl-ATP diphosphatase activity
AA042_RS12070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AA042_RS12085	COG2226	methyltransferase
AA042_RS12115	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AA042_RS12120	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AA042_RS12130	COG0018	arginyl-trna synthetase
AA042_RS12135	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AA042_RS12140	COG0254	rRNA binding
AA042_RS12145	COG1525	nuclease
AA042_RS12150	COG0281	malic enzyme
AA042_RS12185	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AA042_RS12190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AA042_RS12205	COG0070	glutamate synthase
AA042_RS12205	COG0067	glutamate synthase
AA042_RS12205	COG0069	glutamate synthase activity
AA042_RS12210	COG0493	'glutamate synthase
AA042_RS12215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AA042_RS12220	COG3397	chitin binding
AA042_RS12285	COG2814	Major facilitator Superfamily
AA042_RS12290	COG0583	DNA-binding transcription factor activity
AA042_RS12305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AA042_RS12320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AA042_RS12325	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS12375	COG2986	histidine ammonia-lyase
AA042_RS12400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA042_RS12405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AA042_RS12425	COG1192	Involved in chromosome partitioning
AA042_RS12430	COG3118	belongs to the thioredoxin family
AA042_RS12435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
AA042_RS12440	COG1196	nuclear chromosome segregation
AA042_RS12440	COG3264	Mechanosensitive ion channel
AA042_RS12445	COG3263	regulation of cellular component size
AA042_RS12450	COG3501	Rhs element vgr protein
AA042_RS12470	COG0506	proline dehydrogenase activity
AA042_RS12470	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AA042_RS12470	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
AA042_RS12475	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AA042_RS12485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
AA042_RS12490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AA042_RS12555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AA042_RS12565	COG0859	PFAM glycosyl transferase family 9
AA042_RS12570	COG0859	PFAM glycosyl transferase family 9
AA042_RS12575	COG0438	transferase activity, transferring glycosyl groups
AA042_RS12610	COG4772	TonB-dependent receptor
AA042_RS12620	COG2192	nodulation
AA042_RS12625	COG0438	transferase activity, transferring glycosyl groups
AA042_RS12645	COG0438	transferase activity, transferring glycosyl groups
AA042_RS12650	COG1215	transferase activity, transferring glycosyl groups
AA042_RS12670	COG1132	(ABC) transporter
AA042_RS12675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AA042_RS12675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AA042_RS12700	COG1519	Transferase
AA042_RS12710	COG1538	Outer membrane efflux protein
AA042_RS12715	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AA042_RS12730	COG0494	nUDIX hydrolase
AA042_RS12740	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AA042_RS12760	COG3577	Aspartyl protease
AA042_RS12785	COG0688	phosphatidylethanolamine metabolic process
AA042_RS12805	COG1360	Flagellar Motor Protein
AA042_RS12810	COG1162	GTPase activity
AA042_RS12815	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AA042_RS12820	COG2860	membrane
AA042_RS12845	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AA042_RS12845	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AA042_RS12850	COG0802	atpase or kinase
AA042_RS12855	COG0860	N-Acetylmuramoyl-L-alanine amidase
AA042_RS12865	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AA042_RS12870	COG1923	regulation of RNA biosynthetic process
AA042_RS12875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AA042_RS12880	COG0330	HflC and HflK could
AA042_RS12885	COG0330	HflC and HflK could
AA042_RS12890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
AA042_RS12895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AA042_RS12905	COG1178	ABC-type Fe3 transport system permease component
AA042_RS12910	COG1840	ABC-type Fe3 transport system, periplasmic component
AA042_RS12915	COG1858	cytochrome C peroxidase
AA042_RS12920	COG4771	TonB-dependent receptor
AA042_RS12930	COG1595	DNA-templated transcription, initiation
AA042_RS12945	COG0557	exoribonuclease II activity
AA042_RS12950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AA042_RS12955	COG0360	Binds together with S18 to 16S ribosomal RNA
AA042_RS12960	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AA042_RS12970	COG0359	binds to the 23S rRNA
AA042_RS12975	COG0305	Participates in initiation and elongation during chromosome replication
AA042_RS12995	COG1032	radical SAM domain protein
AA042_RS13015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AA042_RS13020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
AA042_RS13025	COG0583	DNA-binding transcription factor activity
AA042_RS13030	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS13035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS13065	COG4221	oxidoreductase activity
AA042_RS13075	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA042_RS13080	COG0830	nickel cation binding
AA042_RS13085	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
AA042_RS13100	COG2982	Protein involved in outer membrane biogenesis
AA042_RS13110	COG0697	spore germination
AA042_RS13115	COG2207	Transcriptional regulator
AA042_RS13130	COG0443	Heat shock 70 kDa protein
AA042_RS13135	COG0484	heat shock protein binding
AA042_RS13140	COG0789	Transcriptional regulator
AA042_RS13160	COG0804	urea catabolic process
AA042_RS13165	COG0832	Belongs to the urease beta subunit family
AA042_RS13180	COG0831	urea catabolic process
AA042_RS13185	COG0829	nickel cation binding
AA042_RS13195	COG1129	ABC transporter
AA042_RS13220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AA042_RS13270	COG3657	addiction module killer protein
AA042_RS13295	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
AA042_RS13330	COG2095	MarC family integral membrane protein
AA042_RS13340	COG0151	Belongs to the GarS family
AA042_RS13345	COG0138	bifunctional purine biosynthesis protein purh
AA042_RS13355	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA042_RS13365	COG2264	protein methyltransferase activity
AA042_RS13430	COG0023	Translation Initiation Factor
AA042_RS13435	COG1166	arginine decarboxylase activity
AA042_RS13440	COG0534	Mate efflux family protein
AA042_RS13445	COG2373	Large extracellular alpha-helical protein
AA042_RS13455	COG4953	penicillin-binding protein 1C
AA042_RS13555	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AA042_RS13585	COG2207	Transcriptional regulator
AA042_RS13600	COG0640	Transcriptional regulator
AA042_RS13635	COG2814	Major facilitator Superfamily
AA042_RS13640	COG0604	alcohol dehydrogenase
AA042_RS13645	COG0583	DNA-binding transcription factor activity
AA042_RS13650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
AA042_RS13745	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
AA042_RS13750	COG1074	ATP-dependent DNA helicase activity
AA042_RS13765	COG2199	diguanylate cyclase activity
AA042_RS13805	COG1113	amino acid transport
AA042_RS13810	COG0583	DNA-binding transcription factor activity
AA042_RS13825	COG2249	NAD(P)H dehydrogenase (quinone) activity
AA042_RS13830	COG0583	DNA-binding transcription factor activity
AA042_RS13840	COG0659	secondary active sulfate transmembrane transporter activity
AA042_RS13855	COG0840	transmembrane signaling receptor activity
AA042_RS13885	COG2314	TM2 domain
AA042_RS13975	COG0840	transmembrane signaling receptor activity
AA042_RS14060	COG0582	viral genome integration into host DNA
AA042_RS14095	COG0247	lactate metabolic process
AA042_RS14100	COG1620	l-lactate permease
AA042_RS14110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AA042_RS14115	COG0733	neurotransmitter:sodium symporter activity
AA042_RS14125	COG2914	Belongs to the UPF0125 (RnfH) family
AA042_RS14130	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AA042_RS14140	COG0497	DNA recombination
AA042_RS14145	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AA042_RS14150	COG0443	Heat shock 70 kDa protein
AA042_RS14155	COG0484	heat shock protein binding
AA042_RS14160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AA042_RS14165	COG0505	Belongs to the CarA family
AA042_RS14170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AA042_RS14175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AA042_RS14190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
AA042_RS14200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AA042_RS14205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AA042_RS14210	COG0149	triose-phosphate isomerase activity
AA042_RS14215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AA042_RS14235	COG0195	Participates in both transcription termination and antitermination
AA042_RS14240	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AA042_RS14245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AA042_RS14250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AA042_RS14255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AA042_RS14260	COG1185	polyribonucleotide nucleotidyltransferase activity
AA042_RS14265	COG2823	Periplasmic or secreted lipoprotein
AA042_RS14275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AA042_RS14290	COG0166	Belongs to the GPI family
AA042_RS14295	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AA042_RS14300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AA042_RS14320	COG4191	Histidine kinase
AA042_RS14325	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA042_RS14340	COG1489	DNA binding
AA042_RS14350	COG4558	Periplasmic binding protein
AA042_RS14360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AA042_RS14380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AA042_RS14390	COG3098	single-species biofilm formation
AA042_RS14395	COG0028	Belongs to the TPP enzyme family
AA042_RS14405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AA042_RS14410	COG1183	phosphatidylcholine synthase activity
AA042_RS14415	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AA042_RS14420	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AA042_RS14455	COG2995	paraquat-inducible protein a
AA042_RS14460	COG2995	paraquat-inducible protein a
AA042_RS14465	COG3008	intermembrane lipid transfer
AA042_RS14480	COG3188	usher protein
AA042_RS14485	COG3121	Chaperone
AA042_RS14520	COG2205	protein histidine kinase activity
AA042_RS14520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA042_RS14525	COG2197	response regulator
AA042_RS14550	COG0456	acetyltransferase
AA042_RS14560	COG0288	reversible hydration of carbon dioxide
AA042_RS14565	COG2031	fatty acid transporter
AA042_RS14590	COG0784	Response regulator, receiver
AA042_RS14590	COG2205	protein histidine kinase activity
AA042_RS14595	COG5001	Diguanylate cyclase
AA042_RS14595	COG3300	MHYT domain
AA042_RS14605	COG2197	response regulator
AA042_RS14610	COG3121	Chaperone
AA042_RS14655	COG2223	nitrite transmembrane transporter activity
AA042_RS14665	COG0012	GTP binding
AA042_RS14670	COG0193	aminoacyl-tRNA hydrolase activity
AA042_RS14675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AA042_RS14680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AA042_RS14690	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AA042_RS14695	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
AA042_RS14705	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AA042_RS14720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AA042_RS14725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AA042_RS14745	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AA042_RS14760	COG4221	oxidoreductase activity
AA042_RS14765	COG0415	Belongs to the DNA photolyase family
AA042_RS14770	COG0789	Transcriptional regulator
AA042_RS14780	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
AA042_RS14790	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AA042_RS14800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AA042_RS14820	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
AA042_RS14830	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AA042_RS14835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA042_RS14840	COG0154	amidase activity
AA042_RS14845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AA042_RS14850	COG1077	Cell shape determining protein MreB Mrl
AA042_RS14855	COG1792	Involved in formation and maintenance of cell shape
AA042_RS14865	COG0424	maF-like protein
AA042_RS14870	COG1530	ribonuclease E activity
AA042_RS14880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AA042_RS14885	COG0312	modulator of DNA gyrase
AA042_RS14890	COG3028	Belongs to the UPF0307 family
AA042_RS14895	COG0312	modulator of DNA gyrase
AA042_RS14930	COG1660	Displays ATPase and GTPase activities
AA042_RS14940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AA042_RS14945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AA042_RS14950	COG1137	ATPase activity
AA042_RS14955	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
AA042_RS14965	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AA042_RS14975	COG1127	ABC transporter
AA042_RS14980	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AA042_RS14985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AA042_RS15005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AA042_RS15010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AA042_RS15015	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AA042_RS15020	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AA042_RS15025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA042_RS15035	COG0175	sulfate reduction
AA042_RS15045	COG0204	Acyl-transferase
AA042_RS15065	COG0386	Belongs to the glutathione peroxidase family
AA042_RS15075	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
AA042_RS15080	COG0492	ferredoxin-NADP+ reductase activity
AA042_RS15120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AA042_RS15125	COG0302	gtp cyclohydrolase
AA042_RS15150	COG0784	Response regulator, receiver
AA042_RS15150	COG4191	Histidine kinase
AA042_RS15160	COG0583	DNA-binding transcription factor activity
AA042_RS15165	COG1380	Effector of murein hydrolase LrgA
AA042_RS15170	COG1346	cytolysis
AA042_RS15190	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
AA042_RS15195	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA042_RS15225	COG4772	TonB-dependent receptor
AA042_RS15230	COG3712	iron ion homeostasis
AA042_RS15235	COG1595	DNA-templated transcription, initiation
AA042_RS15250	COG4774	siderophore transport
AA042_RS15270	COG0583	DNA-binding transcription factor activity
AA042_RS15290	COG1566	PFAM secretion protein HlyD family protein
AA042_RS15310	COG0300	oxidoreductase activity
AA042_RS15335	COG1696	Membrane protein involved in D-alanine export
AA042_RS15350	COG3420	alginic acid biosynthetic process
AA042_RS15360	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
AA042_RS15365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS15375	COG1215	transferase activity, transferring glycosyl groups
AA042_RS15385	COG3022	response to hydroperoxide
AA042_RS15400	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AA042_RS15405	COG3501	Rhs element vgr protein
AA042_RS15440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS15455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA042_RS15455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA042_RS15465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AA042_RS15470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
AA042_RS15475	COG2264	protein methyltransferase activity
AA042_RS15485	COG0315	cyclic pyranopterin monophosphate synthase activity
AA042_RS15490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
AA042_RS15525	COG0400	carboxylic ester hydrolase activity
AA042_RS15535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AA042_RS15540	COG4597	amino acid ABC transporter
AA042_RS15545	COG0765	amino acid transport
AA042_RS15550	COG1126	abc transporter atp-binding protein
AA042_RS15555	COG2807	transmembrane transport
AA042_RS15565	COG2827	Endonuclease containing a URI domain
AA042_RS15575	COG3081	Nucleoid-associated protein
AA042_RS15585	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
AA042_RS15590	COG0525	valine-tRNA ligase activity
AA042_RS15605	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AA042_RS15610	COG0795	lipopolysaccharide-transporting ATPase activity
AA042_RS15615	COG0795	lipopolysaccharide-transporting ATPase activity
AA042_RS15620	COG0481	GTPase activity
AA042_RS15625	COG0681	Belongs to the peptidase S26 family
AA042_RS15630	COG0571	ribonuclease III activity
AA042_RS15635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AA042_RS15640	COG1381	Involved in DNA repair and RecF pathway recombination
AA042_RS15650	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AA042_RS15655	COG0047	phosphoribosylformylglycinamidine synthase activity
AA042_RS15655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AA042_RS15660	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AA042_RS15675	COG0494	nUDIX hydrolase
AA042_RS15695	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
AA042_RS15700	COG0477	Major facilitator Superfamily
AA042_RS15705	COG4536	flavin adenine dinucleotide binding
AA042_RS15715	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AA042_RS15720	COG0228	four-way junction DNA binding
AA042_RS15725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AA042_RS15730	COG0336	Belongs to the RNA methyltransferase TrmD family
AA042_RS15735	COG0335	large ribosomal subunit rRNA binding
AA042_RS15740	COG1607	acyl-coa hydrolase
AA042_RS15750	COG4974	Belongs to the 'phage' integrase family
AA042_RS15785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AA042_RS15815	COG0840	transmembrane signaling receptor activity
AA042_RS15825	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA042_RS15825	COG0457	Tetratricopeptide repeat
AA042_RS15830	COG0835	chemotaxis
AA042_RS15840	COG2201	protein-glutamate methylesterase activity
AA042_RS15845	COG4251	negative regulation of phosphorylation
AA042_RS15845	COG3706	GGDEF domain
AA042_RS15845	COG5001	Diguanylate cyclase
AA042_RS15845	COG2203	Gaf domain
AA042_RS15860	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AA042_RS15880	COG1073	alpha beta
AA042_RS15900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AA042_RS15905	COG0563	adenylate kinase activity
AA042_RS15910	COG1214	PFAM Peptidase M22, glycoprotease
AA042_RS15930	COG0742	ribosomal rna small subunit methyltransferase
AA042_RS15955	COG2937	Belongs to the GPAT DAPAT family
AA042_RS15970	COG2226	methyltransferase
AA042_RS15975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AA042_RS15990	COG2166	iron-sulfur cluster assembly
AA042_RS15995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AA042_RS16000	COG2171	N-acyltransferase activity
AA042_RS16005	COG1393	Belongs to the ArsC family
AA042_RS16010	COG0025	NhaP-type Na H and K H
AA042_RS16015	COG0436	Aminotransferase
AA042_RS16020	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
AA042_RS16025	COG0024	Methionine aminopeptidase
AA042_RS16030	COG0052	Belongs to the universal ribosomal protein uS2 family
AA042_RS16035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AA042_RS16040	COG0528	UMP kinase activity
AA042_RS16045	COG0233	cytoplasmic translational termination
AA042_RS16050	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AA042_RS16060	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AA042_RS16080	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA042_RS16085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA042_RS16090	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA042_RS16095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA042_RS16100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AA042_RS16105	COG0587	DNA-directed DNA polymerase activity
AA042_RS16110	COG0825	malonyl-CoA metabolic process
AA042_RS16115	COG0037	tRNA processing
AA042_RS16120	COG0504	CTP synthase activity
AA042_RS16125	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AA042_RS16130	COG0148	phosphopyruvate hydratase activity
AA042_RS16140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AA042_RS16150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
AA042_RS16155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AA042_RS16160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AA042_RS16165	COG0585	pseudouridine synthase activity
AA042_RS16170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
AA042_RS16175	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AA042_RS16190	COG1902	pentaerythritol trinitrate reductase activity
AA042_RS16195	COG2814	Major facilitator Superfamily
AA042_RS16225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA042_RS16245	COG2267	carboxylic ester hydrolase activity
AA042_RS16260	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AA042_RS16290	COG3180	Ammonia monooxygenase
AA042_RS16315	COG0642	Histidine kinase
AA042_RS16330	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
AA042_RS16395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AA042_RS16405	COG1278	Cold shock
AA042_RS16410	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AA042_RS16415	COG1760	l-serine dehydratase
AA042_RS16425	COG0509	glycine decarboxylation via glycine cleavage system
AA042_RS16465	COG2832	Protein of unknown function (DUF454)
AA042_RS16475	COG4771	TonB-dependent receptor
AA042_RS16480	COG3712	iron ion homeostasis
AA042_RS16490	COG1803	Methylglyoxal synthase
AA042_RS16510	COG0745	RESPONSE REGULATOR receiver
AA042_RS16525	COG1653	transport
AA042_RS16530	COG1175	transmembrane transport
AA042_RS16535	COG0395	ABC-type sugar transport system, permease component
AA042_RS16550	COG0676	glucose-6-phosphate 1-epimerase activity
AA042_RS16555	COG1737	Transcriptional regulator
AA042_RS16570	COG0800	Aldolase
AA042_RS16580	COG3530	Putative quorum-sensing-regulated virulence factor
AA042_RS16590	COG2030	dehydratase
AA042_RS16595	COG2267	carboxylic ester hydrolase activity
AA042_RS16605	COG0318	PFAM AMP-dependent synthetase and ligase
AA042_RS16620	COG1295	ribonuclease BN
AA042_RS16625	COG0242	peptide deformylase activity
AA042_RS16645	COG1609	Transcriptional regulator
AA042_RS16650	COG3265	gluconokinase activity
AA042_RS16660	COG0436	Aminotransferase
AA042_RS16685	COG0584	glycerophosphoryl diester phosphodiesterase
AA042_RS16695	COG3706	GGDEF domain
AA042_RS16705	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA042_RS16720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AA042_RS16775	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS16780	COG3724	N-succinylarginine dihydrolase activity
AA042_RS16790	COG2988	succinylglutamate desuccinylase activity
AA042_RS16800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AA042_RS16805	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
AA042_RS16810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AA042_RS16815	COG0527	aspartate kinase activity
AA042_RS16820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AA042_RS16845	COG2239	Acts as a magnesium transporter
AA042_RS16895	COG2423	ornithine cyclodeaminase activity
AA042_RS16920	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS16925	COG2271	Major facilitator Superfamily
AA042_RS16930	COG0738	Major facilitator superfamily
AA042_RS16935	COG3254	rhamnose metabolic process
AA042_RS16940	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS16950	COG4948	Mandelate Racemase Muconate Lactonizing
AA042_RS16955	COG0179	Fumarylacetoacetate (FAA) hydrolase
AA042_RS16960	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS16965	COG2186	Transcriptional regulator
AA042_RS16985	COG2271	Major facilitator Superfamily
AA042_RS16995	COG1609	Transcriptional regulator
AA042_RS17010	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
AA042_RS17030	COG0835	chemotaxis
AA042_RS17030	COG0784	Response regulator, receiver
AA042_RS17035	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA042_RS17040	COG1815	bacterial-type flagellum-dependent cell motility
AA042_RS17045	COG1558	bacterial-type flagellum-dependent cell motility
AA042_RS17060	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AA042_RS17060	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA042_RS17070	COG1704	LemA family
AA042_RS17090	COG0693	protein deglycase activity
AA042_RS17100	COG1629	transport
AA042_RS17115	COG3422	double-strand break repair
AA042_RS17120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AA042_RS17125	COG0235	Class ii aldolase
AA042_RS17130	COG1396	sequence-specific DNA binding
AA042_RS17140	COG1454	alcohol dehydrogenase
AA042_RS17160	COG1024	Enoyl-CoA hydratase
AA042_RS17165	COG0469	pyruvate kinase activity
AA042_RS17180	COG2925	Exonuclease
AA042_RS17200	COG0433	COG0433 Predicted ATPase
AA042_RS17210	COG0653	protein targeting
AA042_RS17215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AA042_RS17220	COG0494	nUDIX hydrolase
AA042_RS17225	COG2096	Adenosyltransferase
AA042_RS17240	COG1666	GTP binding
AA042_RS17245	COG0668	transmembrane transport
AA042_RS17265	COG2900	Belongs to the SlyX family
AA042_RS17285	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AA042_RS17290	COG0217	transcriptional regulatory protein
AA042_RS17295	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AA042_RS17300	COG0632	four-way junction helicase activity
AA042_RS17305	COG2255	four-way junction helicase activity
AA042_RS17310	COG0824	Thioesterase
AA042_RS17330	COG0823	Involved in the tonB-independent uptake of proteins
AA042_RS17335	COG2885	chlorophyll binding
AA042_RS17345	COG0602	queuosine metabolic process
AA042_RS17350	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AA042_RS17370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AA042_RS17375	COG4783	chaperone-mediated protein folding
AA042_RS17380	COG0425	Belongs to the sulfur carrier protein TusA family
AA042_RS17410	COG1846	Transcriptional regulator
AA042_RS17420	COG1566	PFAM secretion protein HlyD family protein
AA042_RS17425	COG2814	Major facilitator Superfamily
AA042_RS17430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AA042_RS17440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AA042_RS17445	COG0215	cysteine-tRNA ligase activity
AA042_RS17470	COG0544	peptidyl-prolyl cis-trans isomerase activity
AA042_RS17475	COG0740	serine-type endopeptidase activity
AA042_RS17480	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AA042_RS17485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AA042_RS17490	COG0776	regulation of translation
AA042_RS17495	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA042_RS17505	COG4172	Belongs to the ABC transporter superfamily
AA042_RS17510	COG4239	(ABC) transporter, permease
AA042_RS17515	COG4174	ABC transporter (Permease)
AA042_RS17520	COG4166	transmembrane transport
AA042_RS17525	COG4166	transmembrane transport
AA042_RS17530	COG1388	LysM domain
AA042_RS17530	COG0741	lytic transglycosylase activity
AA042_RS17545	COG0328	RNA-DNA hybrid ribonuclease activity
AA042_RS17550	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AA042_RS17565	COG0431	NADPH-dependent FMN reductase
AA042_RS17570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA042_RS17580	COG0583	DNA-binding transcription factor activity
AA042_RS17585	COG0217	transcriptional regulatory protein
AA042_RS17595	COG2866	Carboxypeptidase
AA042_RS17600	COG1522	sequence-specific DNA binding
AA042_RS17625	COG1024	Enoyl-CoA hydratase
AA042_RS17630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AA042_RS17635	COG1960	acyl-CoA dehydrogenase activity
AA042_RS17640	COG0318	PFAM AMP-dependent synthetase and ligase
AA042_RS17655	COG0789	Transcriptional regulator
AA042_RS17670	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AA042_RS17675	COG0708	Exodeoxyribonuclease III
AA042_RS17685	COG0729	surface antigen
AA042_RS17700	COG0583	DNA-binding transcription factor activity
AA042_RS17720	COG2366	antibiotic biosynthetic process
AA042_RS17745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
AA042_RS17750	COG0656	L-ascorbic acid biosynthetic process
AA042_RS17775	COG0577	efflux transmembrane transporter activity
AA042_RS17775	COG1136	(ABC) transporter
AA042_RS17780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS17830	COG2194	sulfuric ester hydrolase activity
AA042_RS17840	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AA042_RS17845	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AA042_RS17850	COG0561	phosphatase activity
AA042_RS17855	COG1024	Enoyl-CoA hydratase
AA042_RS17860	COG2816	NAD+ diphosphatase activity
AA042_RS17885	COG5006	permease, DMT superfamily
AA042_RS17920	COG0720	synthase
AA042_RS17930	COG0745	RESPONSE REGULATOR receiver
AA042_RS17935	COG2205	protein histidine kinase activity
AA042_RS17940	COG0840	transmembrane signaling receptor activity
AA042_RS17945	COG2056	Na+-H+ antiporter family
AA042_RS17955	COG1741	Belongs to the pirin family
AA042_RS17980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AA042_RS17985	COG2205	protein histidine kinase activity
AA042_RS17985	COG3437	response regulator, receiver
AA042_RS17985	COG3850	Histidine kinase
AA042_RS17985	COG4999	Histidine kinase
AA042_RS17990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AA042_RS18000	COG2062	phosphohistidine phosphatase, SixA
AA042_RS18025	COG0628	permease
AA042_RS18055	COG1770	oligopeptidase
AA042_RS18065	COG0121	glutamine amidotransferase
AA042_RS18075	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
AA042_RS18080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AA042_RS18085	COG1984	allophanate hydrolase subunit 2
AA042_RS18095	COG0542	response to heat
AA042_RS18100	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AA042_RS18120	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
AA042_RS18125	COG1643	Atp-dependent helicase
AA042_RS18135	COG1595	DNA-templated transcription, initiation
AA042_RS18145	COG2188	Transcriptional regulator
AA042_RS18155	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AA042_RS18160	COG1132	(ABC) transporter
AA042_RS18175	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA042_RS18190	COG0668	transmembrane transport
AA042_RS18195	COG0513	Belongs to the DEAD box helicase family
AA042_RS18215	COG2996	Protein conserved in bacteria
AA042_RS18225	COG0697	spore germination
AA042_RS18235	COG2832	Protein of unknown function (DUF454)
AA042_RS18245	COG0514	ATP-dependent DNA helicase (RecQ)
AA042_RS18255	COG1752	Esterase of the alpha-beta hydrolase superfamily
AA042_RS18275	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AA042_RS18280	COG0778	Nitroreductase
AA042_RS18285	COG0642	Histidine kinase
AA042_RS18295	COG0745	RESPONSE REGULATOR receiver
AA042_RS18305	COG2350	Protein conserved in bacteria
AA042_RS18310	COG2917	probably involved in intracellular septation
AA042_RS18320	COG0009	L-threonylcarbamoyladenylate synthase
AA042_RS18330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AA042_RS18365	COG2154	pterin-4-alpha-carbinolamine dehydratase
AA042_RS18380	COG4787	bacterial-type flagellum-dependent cell motility
AA042_RS18390	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AA042_RS18395	COG1706	bacterial-type flagellum-dependent cell motility
AA042_RS18420	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AA042_RS18425	COG1334	flagellar protein FlaG
AA042_RS18430	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AA042_RS18460	COG1677	Flagellar hook-basal body complex protein FliE
AA042_RS18495	COG0745	RESPONSE REGULATOR receiver
AA042_RS18535	COG1987	bacterial-type flagellum assembly
AA042_RS18590	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
AA042_RS18595	COG0784	Response regulator, receiver
AA042_RS18595	COG2198	Histidine kinase
AA042_RS18595	COG0643	Histidine kinase
AA042_RS18605	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AA042_RS18615	COG1192	Involved in chromosome partitioning
AA042_RS18625	COG0835	chemotaxis
AA042_RS18635	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AA042_RS18640	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AA042_RS18650	COG4133	protoheme IX ABC transporter activity
AA042_RS18670	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
AA042_RS18675	COG1138	Cytochrome C-type biogenesis protein
AA042_RS18685	COG3088	subunit of a heme lyase
AA042_RS18715	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
AA042_RS18720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AA042_RS18725	COG4413	Urea transporter
AA042_RS18730	COG2084	Dehydrogenase
AA042_RS18735	COG3622	Belongs to the hyi family
AA042_RS18750	COG1309	transcriptional regulator
AA042_RS18755	COG2354	Protein conserved in bacteria
AA042_RS18770	COG1309	transcriptional regulator
AA042_RS18785	COG2233	PERMEase
AA042_RS18795	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
AA042_RS18800	COG4266	Belongs to the allantoicase family
AA042_RS18830	COG2252	PERMEase
AA042_RS18840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS18855	COG0302	gtp cyclohydrolase
AA042_RS18900	COG2840	Smr protein MutS2
AA042_RS18925	COG1073	alpha beta
AA042_RS18930	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AA042_RS18940	COG0235	Class ii aldolase
AA042_RS18945	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
AA042_RS18950	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
AA042_RS18975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AA042_RS18980	COG1368	sulfuric ester hydrolase activity
AA042_RS18990	COG1742	UPF0060 membrane protein
AA042_RS18995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AA042_RS19000	COG3089	Belongs to the UPF0270 family
AA042_RS19005	COG0435	Glutathione S-transferase
AA042_RS19010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AA042_RS19015	COG2920	part of a sulfur-relay system
AA042_RS19070	COG4104	PAAR repeat-containing protein
AA042_RS19105	COG3949	Membrane
AA042_RS19130	COG0154	amidase activity
AA042_RS19150	COG0417	DNA replication proofreading
AA042_RS19170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AA042_RS19175	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
AA042_RS19180	COG4413	Urea transporter
AA042_RS19190	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AA042_RS19205	COG0804	urea catabolic process
AA042_RS19210	COG0832	Belongs to the urease beta subunit family
AA042_RS19220	COG1289	transmembrane transporter activity
AA042_RS19225	COG0277	FAD linked oxidase domain protein
AA042_RS19235	COG2271	Major facilitator Superfamily
AA042_RS19240	COG0583	DNA-binding transcription factor activity
AA042_RS19265	COG1595	DNA-templated transcription, initiation
AA042_RS19275	COG4772	TonB-dependent receptor
AA042_RS19280	COG2223	nitrite transmembrane transporter activity
AA042_RS19285	COG0556	nucleotide-excision repair
AA042_RS19310	COG1414	Transcriptional regulator
AA042_RS19340	COG4948	Mandelate Racemase Muconate Lactonizing
AA042_RS19345	COG4829	muconolactone delta-isomerase
AA042_RS19355	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AA042_RS19365	COG0183	Belongs to the thiolase family
AA042_RS19370	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AA042_RS19400	COG0579	oxidoreductase
AA042_RS19435	COG4993	Dehydrogenase
AA042_RS19450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS19505	COG0765	amino acid transport
AA042_RS19515	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
AA042_RS19530	COG0745	RESPONSE REGULATOR receiver
AA042_RS19540	COG0583	DNA-binding transcription factor activity
AA042_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS19575	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA042_RS19580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS19590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AA042_RS19595	COG0583	DNA-binding transcription factor activity
AA042_RS19610	COG3387	PFAM Glycoside hydrolase 15-related
AA042_RS19635	COG0583	DNA-binding transcription factor activity
AA042_RS19645	COG1335	isochorismatase
AA042_RS19650	COG0183	Belongs to the thiolase family
AA042_RS19670	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AA042_RS19675	COG0066	3-isopropylmalate dehydratase activity
AA042_RS19680	COG2226	methyltransferase
AA042_RS19685	COG0473	3-isopropylmalate dehydrogenase activity
AA042_RS19710	COG0135	phosphoribosylanthranilate isomerase activity
AA042_RS19715	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AA042_RS19720	COG0285	dihydrofolate synthase activity
AA042_RS19730	COG1286	toxin biosynthetic process
AA042_RS19765	COG2342	PFAM TM1410 hypothetical-related protein
AA042_RS19790	COG0438	transferase activity, transferring glycosyl groups
AA042_RS19815	COG0446	pyridine nucleotide-disulphide oxidoreductase
AA042_RS19815	COG1902	pentaerythritol trinitrate reductase activity
AA042_RS19825	COG3038	cytochrome b561
AA042_RS19835	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AA042_RS19840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
AA042_RS19850	COG3139	Protein of unknown function (DUF1315)
AA042_RS19860	COG0308	aminopeptidase N
AA042_RS19865	COG1609	Transcriptional regulator
AA042_RS19885	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS19915	COG0420	3'-5' exonuclease activity
AA042_RS19945	COG0714	Associated with various cellular activities
AA042_RS19950	COG0583	DNA-binding transcription factor activity
AA042_RS19980	COG2853	Lipoprotein
AA042_RS19995	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AA042_RS20045	COG4569	acetaldehyde dehydrogenase (acetylating) activity
AA042_RS20065	COG1012	belongs to the aldehyde dehydrogenase family
AA042_RS20100	COG2204	response regulator
AA042_RS20155	COG2076	Multidrug Resistance protein
AA042_RS20160	COG2076	Multidrug Resistance protein
AA042_RS20165	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AA042_RS20170	COG0726	polysaccharide deacetylase
AA042_RS20180	COG0463	Glycosyl transferase, family 2
AA042_RS20190	COG2267	carboxylic ester hydrolase activity
AA042_RS20195	COG2814	Major facilitator Superfamily
AA042_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS20215	COG1902	pentaerythritol trinitrate reductase activity
AA042_RS20220	COG0318	PFAM AMP-dependent synthetase and ligase
AA042_RS20245	COG0346	lactoylglutathione lyase activity
AA042_RS20260	COG1024	Enoyl-CoA hydratase
AA042_RS20265	COG2070	2-Nitropropane dioxygenase
AA042_RS20275	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS20295	COG0616	signal peptide processing
AA042_RS20340	COG0316	Belongs to the HesB IscA family
AA042_RS20340	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AA042_RS20370	COG0784	Response regulator, receiver
AA042_RS20370	COG2198	Histidine kinase
AA042_RS20370	COG2205	protein histidine kinase activity
AA042_RS20375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AA042_RS20385	COG0784	Response regulator, receiver
AA042_RS20385	COG5002	protein histidine kinase activity
AA042_RS20385	COG2205	protein histidine kinase activity
AA042_RS20410	COG1929	Belongs to the glycerate kinase type-1 family
AA042_RS20415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AA042_RS20435	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AA042_RS20460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AA042_RS20470	COG1609	Transcriptional regulator
AA042_RS20475	COG2124	cytochrome p450
AA042_RS20480	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AA042_RS20505	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
AA042_RS20510	COG0840	transmembrane signaling receptor activity
AA042_RS20515	COG1968	undecaprenyl-diphosphatase activity
AA042_RS20530	COG0583	DNA-binding transcription factor activity
AA042_RS20535	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AA042_RS20545	COG0488	(ABC) transporter
AA042_RS20600	COG3321	synthase
AA042_RS20600	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS20600	COG0604	alcohol dehydrogenase
AA042_RS20620	COG0251	oxidation-reduction process
AA042_RS20630	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AA042_RS20635	COG4191	Histidine kinase
AA042_RS20635	COG0784	Response regulator, receiver
AA042_RS20660	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20690	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS20700	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20715	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20720	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20725	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20740	COG3118	belongs to the thioredoxin family
AA042_RS20740	COG0457	Tetratricopeptide repeat
AA042_RS20750	COG1215	transferase activity, transferring glycosyl groups
AA042_RS20785	COG0154	amidase activity
AA042_RS20800	COG1960	acyl-CoA dehydrogenase activity
AA042_RS20805	COG0318	PFAM AMP-dependent synthetase and ligase
AA042_RS20810	COG4191	Histidine kinase
AA042_RS20820	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AA042_RS20825	COG1280	lysine exporter protein (LysE YggA)
AA042_RS20830	COG4974	Belongs to the 'phage' integrase family
AA042_RS20935	COG2814	Major facilitator Superfamily
AA042_RS20940	COG0583	DNA-binding transcription factor activity
AA042_RS20945	COG1280	lysine exporter protein (LysE YggA)
AA042_RS20955	COG0586	Pfam SNARE associated Golgi protein
AA042_RS20990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AA042_RS20995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AA042_RS21000	COG1063	alcohol dehydrogenase
AA042_RS21020	COG3835	regulator
AA042_RS21025	COG2271	Major facilitator Superfamily
AA042_RS21030	COG2962	Rard protein
AA042_RS21045	COG0745	RESPONSE REGULATOR receiver
AA042_RS21050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AA042_RS21055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AA042_RS21070	COG2200	EAL domain
AA042_RS21085	COG3634	alkyl hydroperoxide reductase activity
AA042_RS21140	COG3258	Cytochrome c
AA042_RS21145	COG2863	cytochrome
AA042_RS21160	COG3145	DNA-N1-methyladenine dioxygenase activity
AA042_RS21175	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
AA042_RS21185	COG0583	DNA-binding transcription factor activity
AA042_RS21200	COG2864	formate dehydrogenase
AA042_RS21205	COG0437	4 iron, 4 sulfur cluster binding
AA042_RS21210	COG3383	formate dehydrogenase (NAD+) activity
AA042_RS21210	COG0243	molybdopterin cofactor binding
AA042_RS21215	COG0113	porphobilinogen synthase activity
AA042_RS21220	COG0640	Transcriptional regulator
AA042_RS21225	COG3321	synthase
AA042_RS21225	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS21225	COG0604	alcohol dehydrogenase
AA042_RS21230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
AA042_RS21245	COG4574	serine-type endopeptidase inhibitor activity
AA042_RS21250	COG2133	pyrroloquinoline quinone binding
AA042_RS21300	COG0477	Major facilitator Superfamily
AA042_RS21335	COG1238	metal cluster binding
AA042_RS21340	COG1408	metallophosphoesterase
AA042_RS21345	COG0864	Transcriptional regulator
AA042_RS21350	COG0747	negative chemotaxis
AA042_RS21355	COG0601	transmembrane transport
AA042_RS21360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AA042_RS21365	COG0444	Belongs to the ABC transporter superfamily
AA042_RS21370	COG1124	(ABC) transporter
AA042_RS21375	COG2814	Major facilitator Superfamily
AA042_RS21405	COG0590	tRNA wobble adenosine to inosine editing
AA042_RS21445	COG3501	Rhs element vgr protein
AA042_RS21490	COG2815	serine threonine protein kinase
AA042_RS21490	COG0515	serine threonine protein kinase
AA042_RS21530	COG2204	response regulator
AA042_RS21575	COG3501	Rhs element vgr protein
AA042_RS21580	COG3209	COG3209 Rhs family protein
AA042_RS21635	COG0789	Transcriptional regulator
AA042_RS21650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AA042_RS21660	COG3655	Transcriptional regulator
AA042_RS21665	COG0626	cystathionine gamma-synthase activity
AA042_RS21670	COG1522	sequence-specific DNA binding
AA042_RS21690	COG2384	SAM-dependent methyltransferase
AA042_RS21695	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS21720	COG1028	Short-chain dehydrogenase reductase Sdr
AA042_RS21755	COG4680	protein conserved in bacteria
AA042_RS21775	COG2826	transposase and inactivated derivatives, IS30 family
AA042_RS21805	COG3179	chitinase
AA042_RS22010	COG0305	Participates in initiation and elongation during chromosome replication
AA042_RS22275	COG3209	COG3209 Rhs family protein