locus-tag	class	description
PISL_RS00095	COG0037	tRNA processing
PISL_RS00100	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PISL_RS00120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
PISL_RS00135	COG0577	efflux transmembrane transporter activity
PISL_RS00160	COG0183	Belongs to the thiolase family
PISL_RS00165	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PISL_RS00190	COG1372	Participates in initiation and elongation during chromosome replication
PISL_RS00190	COG0719	Fe-S assembly protein
PISL_RS00195	COG0396	ATPase activity
PISL_RS00200	COG1695	Transcriptional regulator
PISL_RS00220	COG0113	porphobilinogen synthase activity
PISL_RS00230	COG1522	sequence-specific DNA binding
PISL_RS00250	COG1136	(ABC) transporter
PISL_RS00260	COG0181	hydroxymethylbilane synthase activity
PISL_RS00265	COG0535	radical SAM domain protein
PISL_RS00280	COG0083	homoserine kinase activity
PISL_RS00285	COG0531	amino acid
PISL_RS00370	COG1401	restriction endodeoxyribonuclease activity
PISL_RS00410	COG3842	ATPase activity
PISL_RS00425	COG0577	efflux transmembrane transporter activity
PISL_RS00470	COG1131	(ABC) transporter
PISL_RS00505	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PISL_RS00525	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PISL_RS00530	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PISL_RS00535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PISL_RS00540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PISL_RS00545	COG0788	formyltetrahydrofolate deformylase activity
PISL_RS00550	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PISL_RS00555	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PISL_RS00560	COG0151	Belongs to the GarS family
PISL_RS00570	COG0047	phosphoribosylformylglycinamidine synthase activity
PISL_RS00580	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PISL_RS00595	COG0535	radical SAM domain protein
PISL_RS00600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PISL_RS00605	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PISL_RS00625	COG1648	precorrin-2 dehydrogenase activity
PISL_RS00625	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PISL_RS00640	COG1968	undecaprenyl-diphosphatase activity
PISL_RS00650	COG0134	indole-3-glycerol-phosphate synthase activity
PISL_RS00705	COG0477	Major facilitator Superfamily
PISL_RS00735	COG0297	glycogen (starch) synthase activity
PISL_RS00750	COG0174	glutamine synthetase
PISL_RS00830	COG0243	molybdopterin cofactor binding
PISL_RS00850	COG0450	alkyl hydroperoxide reductase
PISL_RS00855	COG2855	membrane
PISL_RS00860	COG2920	part of a sulfur-relay system
PISL_RS00870	COG2221	Nitrite and sulphite reductase 4Fe-4S
PISL_RS00915	COG2181	nitrate reductase activity
PISL_RS00925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PISL_RS01000	COG0864	Transcriptional regulator
PISL_RS01015	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PISL_RS01025	COG2181	nitrate reductase activity
PISL_RS01025	COG0247	lactate metabolic process
PISL_RS01055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PISL_RS01060	COG0409	Hydrogenase expression formation protein
PISL_RS01070	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PISL_RS01085	COG1122	ATPase activity
PISL_RS01100	COG0310	cobalt ion transport
PISL_RS01105	COG1120	ATPase activity
PISL_RS01110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PISL_RS01125	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PISL_RS01165	COG0602	queuosine metabolic process
PISL_RS01175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PISL_RS01180	COG1429	ligase activity, forming nitrogen-metal bonds
PISL_RS01185	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
PISL_RS01200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PISL_RS01205	COG1120	ATPase activity
PISL_RS01275	COG0446	pyridine nucleotide-disulphide oxidoreductase
PISL_RS01295	COG1012	belongs to the aldehyde dehydrogenase family
PISL_RS01300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PISL_RS01315	COG0517	IMP dehydrogenase activity
PISL_RS01315	COG0516	GMP reductase activity
PISL_RS01320	COG0516	GMP reductase activity
PISL_RS01320	COG0517	IMP dehydrogenase activity
PISL_RS01325	COG0516	GMP reductase activity
PISL_RS01325	COG0517	IMP dehydrogenase activity
PISL_RS01340	COG0581	inorganic phosphate transmembrane transporter activity
PISL_RS01345	COG0573	inorganic phosphate transmembrane transporter activity
PISL_RS01350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PISL_RS01365	COG1918	ferrous iron import across plasma membrane
PISL_RS01365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PISL_RS01370	COG4670	ketone body catabolic process
PISL_RS01385	COG0243	molybdopterin cofactor binding
PISL_RS01395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PISL_RS01400	COG0477	Major facilitator Superfamily
PISL_RS01405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PISL_RS01410	COG0460	homoserine dehydrogenase
PISL_RS01420	COG0527	aspartate kinase activity
PISL_RS01425	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PISL_RS01435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PISL_RS01450	COG0137	argininosuccinate synthase activity
PISL_RS01455	COG0165	Argininosuccinate lyase
PISL_RS01520	COG1404	Belongs to the peptidase S8 family
PISL_RS01525	COG0517	IMP dehydrogenase activity
PISL_RS01525	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PISL_RS01555	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PISL_RS01560	COG1196	nuclear chromosome segregation
PISL_RS01570	COG0051	transcription antitermination factor activity, RNA binding
PISL_RS01575	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PISL_RS01595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PISL_RS01620	COG0410	ABC transporter
PISL_RS01655	COG0651	ATP synthesis coupled electron transport
PISL_RS01660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PISL_RS01660	COG2111	Na H antiporter
PISL_RS01665	COG1007	ATP synthesis coupled electron transport
PISL_RS01670	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PISL_RS01675	COG0674	pyruvate-flavodoxin oxidoreductase activity
PISL_RS01680	COG1013	pyruvate-flavodoxin oxidoreductase activity
PISL_RS01685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PISL_RS01690	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PISL_RS01700	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PISL_RS01705	COG0649	NAD binding
PISL_RS01725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PISL_RS01730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PISL_RS01760	COG2267	carboxylic ester hydrolase activity
PISL_RS01775	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PISL_RS01780	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PISL_RS01790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PISL_RS01795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PISL_RS01795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PISL_RS01840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PISL_RS01860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PISL_RS01870	COG0516	GMP reductase activity
PISL_RS01870	COG0517	IMP dehydrogenase activity
PISL_RS01900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PISL_RS01920	COG0017	Asparaginyl-tRNA synthetase
PISL_RS01935	COG0009	L-threonylcarbamoyladenylate synthase
PISL_RS01945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PISL_RS01970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PISL_RS01970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PISL_RS01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PISL_RS01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PISL_RS02020	COG0433	COG0433 Predicted ATPase
PISL_RS02040	COG1102	Psort location Cytoplasmic, score
PISL_RS02045	COG0493	'glutamate synthase
PISL_RS02050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PISL_RS02060	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PISL_RS02065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PISL_RS02070	COG1234	tRNA 3'-trailer cleavage
PISL_RS02175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PISL_RS02195	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PISL_RS02270	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PISL_RS02280	COG0303	'Molybdopterin
PISL_RS02285	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PISL_RS02300	COG0483	inositol monophosphate 1-phosphatase activity
PISL_RS02325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PISL_RS02330	COG0180	Tryptophanyl-tRNA synthetase
PISL_RS02365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PISL_RS02385	COG0081	regulation of translation
PISL_RS02405	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
PISL_RS02425	COG1079	Belongs to the binding-protein-dependent transport system permease family
PISL_RS02435	COG3845	ABC transporter
PISL_RS02440	COG1744	ABC transporter substrate-binding protein PnrA-like
PISL_RS02485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PISL_RS02485	COG0045	succinate-CoA ligase (ADP-forming) activity
PISL_RS02485	COG1042	CoA-binding domain protein
PISL_RS02510	COG0667	Aldo Keto reductase
PISL_RS02540	COG1234	tRNA 3'-trailer cleavage
PISL_RS02545	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PISL_RS02550	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PISL_RS02555	COG1144	Oxidoreductase
PISL_RS02560	COG0674	pyruvate-flavodoxin oxidoreductase activity
PISL_RS02565	COG1013	pyruvate-flavodoxin oxidoreductase activity
PISL_RS02570	COG0459	protein refolding
PISL_RS02600	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PISL_RS02605	COG0284	orotidine-5'-phosphate decarboxylase activity
PISL_RS02605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PISL_RS02610	COG0167	dihydroorotate dehydrogenase activity
PISL_RS02630	COG0585	pseudouridine synthase activity
PISL_RS02640	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PISL_RS02655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PISL_RS02660	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PISL_RS02700	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PISL_RS02715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PISL_RS02725	COG0528	UMP kinase activity
PISL_RS02730	COG0537	adenosine 5'-monophosphoramidase activity
PISL_RS02740	COG0012	GTP binding
PISL_RS02750	COG2239	Acts as a magnesium transporter
PISL_RS02755	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PISL_RS02775	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PISL_RS02800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PISL_RS02815	COG1618	nucleotide phosphatase activity, acting on free nucleotides
PISL_RS02835	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PISL_RS02845	COG0028	Belongs to the TPP enzyme family
PISL_RS02870	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PISL_RS02890	COG4608	Belongs to the ABC transporter superfamily
PISL_RS02895	COG0444	Belongs to the ABC transporter superfamily
PISL_RS02905	COG0617	tRNA 3'-terminal CCA addition
PISL_RS02905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PISL_RS02905	COG0517	IMP dehydrogenase activity
PISL_RS02910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PISL_RS02935	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PISL_RS02985	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PISL_RS02990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PISL_RS03075	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PISL_RS03080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PISL_RS03095	COG0519	Catalyzes the synthesis of GMP from XMP
PISL_RS03095	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PISL_RS03110	COG4166	transmembrane transport
PISL_RS03115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PISL_RS03120	COG0601	transmembrane transport
PISL_RS03140	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PISL_RS03160	COG0039	L-malate dehydrogenase activity
PISL_RS03175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PISL_RS03190	COG1201	RNA secondary structure unwinding
PISL_RS03225	COG0488	(ABC) transporter
PISL_RS03240	COG2860	membrane
PISL_RS03270	COG2226	methyltransferase
PISL_RS03285	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PISL_RS03290	COG0318	PFAM AMP-dependent synthetase and ligase
PISL_RS03335	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PISL_RS03340	COG2086	electron transfer activity
PISL_RS03350	COG0644	oxidoreductase
PISL_RS03385	COG0049	tRNA binding
PISL_RS03390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PISL_RS03395	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PISL_RS03425	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PISL_RS03435	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PISL_RS03435	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PISL_RS03465	COG1053	succinate dehydrogenase
PISL_RS03480	COG1404	Belongs to the peptidase S8 family
PISL_RS03505	COG0017	Asparaginyl-tRNA synthetase
PISL_RS03510	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PISL_RS03525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PISL_RS03545	COG1515	deoxyribonuclease V activity
PISL_RS03550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PISL_RS03550	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PISL_RS03570	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
PISL_RS03580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PISL_RS03590	COG0200	Binds to the 23S rRNA
PISL_RS03615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PISL_RS03620	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PISL_RS03625	COG0085	RNA polymerase activity
PISL_RS03635	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
PISL_RS03700	COG1573	uracil-dna glycosylase
PISL_RS03715	COG0189	ligase activity
PISL_RS03735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PISL_RS03765	COG1078	dGTPase activity
PISL_RS03795	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PISL_RS03800	COG2414	aldehyde ferredoxin oxidoreductase
PISL_RS03845	COG2264	protein methyltransferase activity
PISL_RS03885	COG0430	RNA-3'-phosphate cyclase activity
PISL_RS03890	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PISL_RS03900	COG2086	electron transfer activity
PISL_RS03905	COG0017	Asparaginyl-tRNA synthetase
PISL_RS03910	COG3830	Belongs to the UPF0237 family
PISL_RS03915	COG2848	UPF0210 protein
PISL_RS03940	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PISL_RS03975	COG0436	Aminotransferase
PISL_RS04000	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PISL_RS04025	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PISL_RS04075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PISL_RS04085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PISL_RS04090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PISL_RS04110	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PISL_RS04115	COG0504	CTP synthase activity
PISL_RS04135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PISL_RS04200	COG0417	DNA replication proofreading
PISL_RS04210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PISL_RS04230	COG0442	prolyl-tRNA aminoacylation
PISL_RS04300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PISL_RS04350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PISL_RS04380	COG0542	response to heat
PISL_RS04410	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PISL_RS04535	COG0626	cystathionine gamma-synthase activity
PISL_RS04550	COG0419	ATPase involved in DNA repair
PISL_RS04575	COG0778	Nitroreductase
PISL_RS04610	COG0423	glycine-tRNA ligase activity
PISL_RS04620	COG0010	Belongs to the arginase family
PISL_RS04650	COG1131	(ABC) transporter
PISL_RS04660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PISL_RS04690	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PISL_RS04695	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PISL_RS04700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PISL_RS04705	COG0601	transmembrane transport
PISL_RS04730	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PISL_RS04740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PISL_RS04785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PISL_RS04790	COG0434	BtpA family
PISL_RS04805	COG0501	Belongs to the peptidase M48B family
PISL_RS04830	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
PISL_RS04855	COG0235	Class ii aldolase
PISL_RS04915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PISL_RS04920	COG1201	RNA secondary structure unwinding
PISL_RS04950	COG0459	protein refolding
PISL_RS04980	COG0200	Binds to the 23S rRNA
PISL_RS04995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PISL_RS05010	COG2414	aldehyde ferredoxin oxidoreductase
PISL_RS05025	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PISL_RS05040	COG1129	ABC transporter
PISL_RS05045	COG4603	Belongs to the binding-protein-dependent transport system permease family
PISL_RS05060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PISL_RS05105	COG3833	ABC-type maltose transport systems, permease component
PISL_RS05110	COG0501	Belongs to the peptidase M48B family
PISL_RS05120	COG0303	'Molybdopterin
PISL_RS05205	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PISL_RS05215	COG1136	(ABC) transporter
PISL_RS05225	COG2409	Drug exporters of the RND superfamily
PISL_RS05245	COG0037	tRNA processing
PISL_RS05275	COG0735	belongs to the Fur family
PISL_RS05285	COG0045	succinate-CoA ligase (ADP-forming) activity
PISL_RS05290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PISL_RS05295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PISL_RS05300	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PISL_RS05375	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PISL_RS05380	COG1324	tolerance protein
PISL_RS05405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PISL_RS05410	COG1394	ATPase activity, coupled to movement of substances
PISL_RS05430	COG0330	HflC and HflK could
PISL_RS05460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PISL_RS05470	COG0284	orotidine-5'-phosphate decarboxylase activity
PISL_RS05490	COG0540	Belongs to the ATCase OTCase family
PISL_RS05510	COG4962	Type ii secretion system protein e
PISL_RS05540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PISL_RS05545	COG1426	Protein conserved in bacteria
PISL_RS05575	COG2095	MarC family integral membrane protein
PISL_RS05580	COG0489	protein tyrosine kinase activity
PISL_RS05585	COG0295	cytidine deaminase activity
PISL_RS05600	COG1028	Short-chain dehydrogenase reductase Sdr
PISL_RS05605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PISL_RS05610	COG0315	cyclic pyranopterin monophosphate synthase activity
PISL_RS05620	COG1304	FMN binding
PISL_RS05625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PISL_RS05635	COG1047	Peptidyl-prolyl cis-trans
PISL_RS05640	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PISL_RS05645	COG0148	phosphopyruvate hydratase activity
PISL_RS05675	COG1716	ATPase activity
PISL_RS05675	COG1131	(ABC) transporter
PISL_RS05675	COG0842	Transport permease protein
PISL_RS05680	COG0052	Belongs to the universal ribosomal protein uS2 family
PISL_RS05685	COG1355	regulation of microtubule-based process
PISL_RS05695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PISL_RS05700	COG0215	cysteine-tRNA ligase activity
PISL_RS05735	COG1793	dna ligase
PISL_RS05755	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PISL_RS05805	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PISL_RS05845	COG1546	Belongs to the CinA family
PISL_RS05845	COG1058	Belongs to the CinA family
PISL_RS05860	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PISL_RS05875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PISL_RS05885	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PISL_RS05885	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PISL_RS05915	COG4581	dead DEAH box helicase
PISL_RS06035	COG1013	pyruvate-flavodoxin oxidoreductase activity
PISL_RS06065	COG2095	MarC family integral membrane protein
PISL_RS06070	COG1980	fructose-bisphosphate aldolase activity
PISL_RS06090	COG0189	ligase activity
PISL_RS06130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PISL_RS06135	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PISL_RS06145	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PISL_RS06150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PISL_RS06160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PISL_RS06220	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PISL_RS06225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PISL_RS06230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PISL_RS06235	COG0140	phosphoribosyl-ATP diphosphatase activity
PISL_RS06240	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PISL_RS06245	COG0107	imidazoleglycerol-phosphate synthase activity
PISL_RS06250	COG0131	Imidazoleglycerol-phosphate dehydratase
PISL_RS06255	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PISL_RS06275	COG0252	asparaginase activity
PISL_RS06295	COG0517	IMP dehydrogenase activity
PISL_RS06295	COG0516	GMP reductase activity
PISL_RS06320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PISL_RS06325	COG1144	Oxidoreductase
PISL_RS06330	COG0674	pyruvate-flavodoxin oxidoreductase activity
PISL_RS06335	COG1013	pyruvate-flavodoxin oxidoreductase activity
PISL_RS06390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PISL_RS06390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PISL_RS06400	COG1110	DNA topoisomerase II activity
PISL_RS06405	COG0495	leucyl-tRNA aminoacylation
PISL_RS06460	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PISL_RS06485	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PISL_RS06495	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
PISL_RS06500	COG2084	Dehydrogenase
PISL_RS06505	COG1804	L-carnitine dehydratase bile acid-inducible protein F
PISL_RS06580	COG0101	tRNA pseudouridine synthase activity
PISL_RS06620	COG1121	(ABC) transporter
PISL_RS06635	COG0189	ligase activity
PISL_RS06650	COG1254	Belongs to the acylphosphatase family
PISL_RS06655	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PISL_RS06680	COG3842	ATPase activity
PISL_RS06685	COG0183	Belongs to the thiolase family
PISL_RS06690	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PISL_RS06705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PISL_RS06710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PISL_RS06735	COG1506	peptidase
PISL_RS06740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PISL_RS06745	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PISL_RS06760	COG1640	4-alpha-glucanotransferase
PISL_RS06775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PISL_RS06790	COG1131	(ABC) transporter
PISL_RS06795	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PISL_RS06800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PISL_RS06805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PISL_RS06810	COG0516	GMP reductase activity
PISL_RS06810	COG0517	IMP dehydrogenase activity
PISL_RS06820	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PISL_RS06835	COG0477	Major facilitator Superfamily
PISL_RS06855	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PISL_RS06860	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PISL_RS06870	COG2226	methyltransferase
PISL_RS06875	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
PISL_RS06895	COG1139	Iron-sulfur cluster binding protein
PISL_RS06900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
PISL_RS06905	COG0277	FAD linked oxidase domain protein
PISL_RS06910	COG0247	lactate metabolic process
PISL_RS06920	COG1620	l-lactate permease
PISL_RS06925	COG1139	Iron-sulfur cluster binding protein
PISL_RS06955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PISL_RS06990	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PISL_RS06995	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PISL_RS07025	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PISL_RS07030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PISL_RS07035	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PISL_RS07040	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PISL_RS07045	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
PISL_RS07080	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PISL_RS07145	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
PISL_RS07155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PISL_RS07170	COG0616	signal peptide processing
PISL_RS07180	COG1136	(ABC) transporter
PISL_RS07245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PISL_RS07280	COG0352	thiamine-phosphate diphosphorylase activity
PISL_RS07280	COG0351	phosphomethylpyrimidine kinase
PISL_RS07325	COG1051	belongs to the nudix hydrolase family
PISL_RS07355	COG1024	Enoyl-CoA hydratase
PISL_RS07360	COG0318	PFAM AMP-dependent synthetase and ligase
PISL_RS07365	COG1960	acyl-CoA dehydrogenase activity
PISL_RS07370	COG0183	Belongs to the thiolase family
PISL_RS07395	COG1444	tRNA N-acetyltransferase activity
PISL_RS07435	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PISL_RS07455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PISL_RS07465	COG0004	ammonium transporteR
PISL_RS07540	COG0730	response to heat
PISL_RS07650	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PISL_RS07680	COG0297	glycogen (starch) synthase activity
PISL_RS07700	COG0438	transferase activity, transferring glycosyl groups
PISL_RS07705	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PISL_RS07725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PISL_RS07730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PISL_RS07735	COG3119	arylsulfatase activity
PISL_RS07755	COG0529	Catalyzes the synthesis of activated sulfate
PISL_RS07765	COG2046	Belongs to the sulfate adenylyltransferase family
PISL_RS07830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PISL_RS07835	COG0581	inorganic phosphate transmembrane transporter activity
PISL_RS07840	COG0573	inorganic phosphate transmembrane transporter activity
PISL_RS07845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PISL_RS07855	COG0300	oxidoreductase activity
PISL_RS07930	COG1337	RAMP superfamily
PISL_RS07960	COG0326	Molecular chaperone. Has ATPase activity
PISL_RS08000	COG2890	protein-(glutamine-N5) methyltransferase activity
PISL_RS08035	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PISL_RS08080	COG2171	N-acyltransferase activity
PISL_RS08105	COG0163	prenyltransferase activity
PISL_RS08130	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PISL_RS08145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PISL_RS08195	COG0154	amidase activity
PISL_RS08200	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PISL_RS08230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PISL_RS08255	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PISL_RS08260	COG3842	ATPase activity
PISL_RS08285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PISL_RS08300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PISL_RS08330	COG0124	histidyl-tRNA synthetase
PISL_RS08340	COG0463	Glycosyl transferase, family 2
PISL_RS08355	COG0105	UTP biosynthetic process
PISL_RS08360	COG1007	ATP synthesis coupled electron transport
PISL_RS08365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PISL_RS08365	COG2111	Na H antiporter
PISL_RS08370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PISL_RS08390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PISL_RS08395	COG0649	NAD binding
PISL_RS08435	COG0308	aminopeptidase N
PISL_RS08440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PISL_RS08475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PISL_RS08505	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
PISL_RS08565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PISL_RS08615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PISL_RS08615	COG0072	phenylalanine-tRNA ligase activity
PISL_RS08665	COG0371	Dehydrogenase
PISL_RS08675	COG0281	malic enzyme
PISL_RS08680	COG0372	Belongs to the citrate synthase family
PISL_RS08690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PISL_RS08730	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PISL_RS08735	COG2079	MmgE PrpD family protein
PISL_RS08740	COG0492	ferredoxin-NADP+ reductase activity
PISL_RS08745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PISL_RS08775	COG0126	phosphoglycerate kinase activity
PISL_RS08785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PISL_RS08790	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PISL_RS08810	COG1260	myo-inositol-1-phosphate synthase
PISL_RS08830	COG0247	lactate metabolic process
PISL_RS08830	COG2181	nitrate reductase activity
PISL_RS08845	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
PISL_RS08865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PISL_RS08935	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
PISL_RS08945	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PISL_RS08955	COG0719	Fe-S assembly protein
PISL_RS08995	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PISL_RS09005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PISL_RS09015	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PISL_RS09045	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PISL_RS09055	COG1132	(ABC) transporter
PISL_RS09060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PISL_RS09070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PISL_RS09085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PISL_RS09095	COG1702	phosphate starvation-inducible protein PhoH
PISL_RS09110	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PISL_RS09115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PISL_RS09120	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PISL_RS09125	COG3958	Transketolase
PISL_RS09130	COG3959	Transketolase, thiamine diphosphate binding domain
PISL_RS09135	COG0180	Tryptophanyl-tRNA synthetase
PISL_RS09140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PISL_RS09145	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PISL_RS09185	COG0710	3-dehydroquinate dehydratase activity
PISL_RS09195	COG0436	Aminotransferase
PISL_RS09270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PISL_RS09275	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PISL_RS09280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PISL_RS09305	COG0066	3-isopropylmalate dehydratase activity
PISL_RS09310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PISL_RS09315	COG0473	3-isopropylmalate dehydrogenase activity
PISL_RS09320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PISL_RS09340	COG0765	amino acid transport
PISL_RS09350	COG0243	molybdopterin cofactor binding
PISL_RS09365	COG0717	Belongs to the dCTP deaminase family
PISL_RS09380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PISL_RS09415	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
PISL_RS09420	COG0006	proline dipeptidase activity
PISL_RS09430	COG0277	FAD linked oxidase domain protein
PISL_RS09465	COG2255	four-way junction helicase activity
PISL_RS09475	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PISL_RS09485	COG2151	metal-sulfur cluster biosynthetic enzyme
PISL_RS09520	COG1960	acyl-CoA dehydrogenase activity
PISL_RS09525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PISL_RS09535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PISL_RS09555	COG0450	alkyl hydroperoxide reductase
PISL_RS09565	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PISL_RS09570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PISL_RS09660	COG1489	DNA binding
PISL_RS09680	COG0730	response to heat
PISL_RS09695	COG0589	response to stress
PISL_RS09725	COG0574	Belongs to the PEP-utilizing enzyme family
PISL_RS09725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PISL_RS09735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PISL_RS09750	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PISL_RS09795	COG0556	nucleotide-excision repair
PISL_RS09840	COG0730	response to heat
PISL_RS09845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PISL_RS09850	COG0159	tryptophan synthase activity
PISL_RS09855	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PISL_RS09855	COG0512	Glutamine amidotransferase of anthranilate synthase
PISL_RS09860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PISL_RS09870	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PISL_RS09885	COG0135	phosphoribosylanthranilate isomerase activity
PISL_RS09900	COG1573	uracil-dna glycosylase
PISL_RS09910	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PISL_RS09965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PISL_RS09965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PISL_RS10020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PISL_RS10040	COG1063	alcohol dehydrogenase
PISL_RS10045	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PISL_RS10080	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PISL_RS10095	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PISL_RS10125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PISL_RS10130	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PISL_RS10155	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PISL_RS10160	COG0477	Major facilitator Superfamily
PISL_RS10165	COG2814	Major facilitator Superfamily
PISL_RS10170	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PISL_RS10230	COG0437	4 iron, 4 sulfur cluster binding
PISL_RS10240	COG0243	molybdopterin cofactor binding
PISL_RS10260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PISL_RS10270	COG3383	formate dehydrogenase (NAD+) activity
PISL_RS10270	COG0243	molybdopterin cofactor binding
PISL_RS10275	COG0437	4 iron, 4 sulfur cluster binding
PISL_RS10290	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
PISL_RS10320	COG1342	Belongs to the UPF0251 family
PISL_RS10370	COG1131	(ABC) transporter