locus-tag	class	description
PFC_RS00010	COG0601	transmembrane transport
PFC_RS00015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFC_RS00020	COG0444	Belongs to the ABC transporter superfamily
PFC_RS00025	COG4608	Belongs to the ABC transporter superfamily
PFC_RS00035	COG2140	Oxalate decarboxylase
PFC_RS00045	COG0047	phosphoribosylformylglycinamidine synthase activity
PFC_RS00050	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PFC_RS00060	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PFC_RS00060	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PFC_RS00065	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PFC_RS00070	COG0538	isocitrate dehydrogenase activity
PFC_RS00075	COG0372	Belongs to the citrate synthase family
PFC_RS00080	COG0067	glutamate synthase
PFC_RS00095	COG0137	argininosuccinate synthase activity
PFC_RS00100	COG0165	Argininosuccinate lyase
PFC_RS00105	COG0189	ligase activity
PFC_RS00120	COG0417	DNA replication proofreading
PFC_RS00125	COG1234	tRNA 3'-trailer cleavage
PFC_RS00135	COG0148	phosphopyruvate hydratase activity
PFC_RS00140	COG0424	maF-like protein
PFC_RS00155	COG0720	synthase
PFC_RS00160	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PFC_RS00170	COG0546	phosphoglycolate phosphatase activity
PFC_RS00185	COG1418	mRNA catabolic process
PFC_RS00205	COG0640	Transcriptional regulator
PFC_RS00230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PFC_RS00295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PFC_RS00300	COG1522	sequence-specific DNA binding
PFC_RS00305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PFC_RS00335	COG0539	negative regulation of cytoplasmic translation
PFC_RS00335	COG1185	polyribonucleotide nucleotidyltransferase activity
PFC_RS00350	COG0011	TIGRFAM Protein of
PFC_RS00370	COG1510	regulation of RNA biosynthetic process
PFC_RS00375	COG0124	histidyl-tRNA synthetase
PFC_RS00380	COG0156	8-amino-7-oxononanoate synthase activity
PFC_RS00390	COG0456	acetyltransferase
PFC_RS00395	COG0475	glutathione-regulated potassium exporter activity
PFC_RS00405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PFC_RS00420	COG1449	Belongs to the glycosyl hydrolase 57 family
PFC_RS00425	COG0037	tRNA processing
PFC_RS00435	COG0475	glutathione-regulated potassium exporter activity
PFC_RS00440	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PFC_RS00475	COG1254	Belongs to the acylphosphatase family
PFC_RS00485	COG0517	IMP dehydrogenase activity
PFC_RS00485	COG0516	GMP reductase activity
PFC_RS00505	COG2151	metal-sulfur cluster biosynthetic enzyme
PFC_RS00510	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
PFC_RS00515	COG0525	valine-tRNA ligase activity
PFC_RS00525	COG1899	peptidyl-lysine modification to peptidyl-hypusine
PFC_RS00530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PFC_RS00545	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PFC_RS00565	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PFC_RS00575	COG1492	cobalamin metabolic process
PFC_RS00585	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PFC_RS00600	COG0009	L-threonylcarbamoyladenylate synthase
PFC_RS00610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PFC_RS00630	COG1131	(ABC) transporter
PFC_RS00660	COG0697	spore germination
PFC_RS00665	COG1506	peptidase
PFC_RS00665	COG0823	Involved in the tonB-independent uptake of proteins
PFC_RS00665	COG4946	Tricorn protease homolog
PFC_RS00670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFC_RS00680	COG0517	IMP dehydrogenase activity
PFC_RS00680	COG0516	GMP reductase activity
PFC_RS00685	COG0864	Transcriptional regulator
PFC_RS00800	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PFC_RS00815	COG2414	aldehyde ferredoxin oxidoreductase
PFC_RS00850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PFC_RS00850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PFC_RS00910	COG0012	GTP binding
PFC_RS00925	COG0733	neurotransmitter:sodium symporter activity
PFC_RS00930	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFC_RS00935	COG1363	Peptidase, m42
PFC_RS00940	COG0730	response to heat
PFC_RS00950	COG0237	dephospho-CoA kinase activity
PFC_RS00970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PFC_RS00975	COG4608	Belongs to the ABC transporter superfamily
PFC_RS00980	COG4608	Belongs to the ABC transporter superfamily
PFC_RS00985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFC_RS00990	COG0601	transmembrane transport
PFC_RS01000	COG2723	6-phospho-beta-galactosidase activity
PFC_RS01030	COG0530	calcium, potassium:sodium antiporter activity
PFC_RS01075	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PFC_RS01090	COG1160	GTP binding
PFC_RS01120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PFC_RS01135	COG0714	Associated with various cellular activities
PFC_RS01165	COG0668	transmembrane transport
PFC_RS01195	COG0714	Associated with various cellular activities
PFC_RS01215	COG0151	Belongs to the GarS family
PFC_RS01230	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PFC_RS01235	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PFC_RS01240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PFC_RS01245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PFC_RS01260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PFC_RS01265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PFC_RS01300	COG3291	Pkd domain containing protein
PFC_RS01325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PFC_RS01325	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PFC_RS01330	COG1085	galactose-1-phosphate uridylyltransferase
PFC_RS01335	COG2723	6-phospho-beta-galactosidase activity
PFC_RS01350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PFC_RS01365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PFC_RS01375	COG0174	glutamine synthetase
PFC_RS01405	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PFC_RS01415	COG1056	cytidyltransferase-related domain
PFC_RS01415	COG1051	belongs to the nudix hydrolase family
PFC_RS01435	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PFC_RS01450	COG1215	transferase activity, transferring glycosyl groups
PFC_RS01460	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PFC_RS01485	COG0515	serine threonine protein kinase
PFC_RS01490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PFC_RS01495	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PFC_RS01500	COG1546	Belongs to the CinA family
PFC_RS01500	COG1058	Belongs to the CinA family
PFC_RS01520	COG2267	carboxylic ester hydrolase activity
PFC_RS01545	COG2894	cell division
PFC_RS01550	COG0697	spore germination
PFC_RS01595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PFC_RS01600	COG1110	DNA topoisomerase II activity
PFC_RS01635	COG1618	nucleotide phosphatase activity, acting on free nucleotides
PFC_RS01640	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
PFC_RS01645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFC_RS01650	COG1444	tRNA N-acetyltransferase activity
PFC_RS01685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PFC_RS01695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PFC_RS01700	COG1115	amino acid carrier protein
PFC_RS01715	COG0714	Associated with various cellular activities
PFC_RS01735	COG2119	membrane
PFC_RS01740	COG0436	Aminotransferase
PFC_RS01755	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PFC_RS01760	COG1192	Involved in chromosome partitioning
PFC_RS01770	COG1122	ATPase activity
PFC_RS01785	COG0310	cobalt ion transport
PFC_RS01840	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PFC_RS01845	COG0024	Methionine aminopeptidase
PFC_RS01855	COG0303	'Molybdopterin
PFC_RS01885	COG0298	carbon dioxide binding
PFC_RS01890	COG0409	Hydrogenase expression formation protein
PFC_RS01905	COG0798	PFAM Bile acid sodium symporter
PFC_RS01910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PFC_RS01930	COG1028	Short-chain dehydrogenase reductase Sdr
PFC_RS01965	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PFC_RS01995	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
PFC_RS02075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PFC_RS02095	COG1111	helicase
PFC_RS02095	COG1205	dead DEAH box helicase
PFC_RS02105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PFC_RS02115	COG1793	dna ligase
PFC_RS02115	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PFC_RS02120	COG1473	amidohydrolase
PFC_RS02125	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PFC_RS02130	COG0540	Belongs to the ATCase OTCase family
PFC_RS02140	COG0351	phosphomethylpyrimidine kinase
PFC_RS02140	COG1992	Thiamine-phosphate synthase
PFC_RS02155	COG0309	Hydrogenase expression formation protein (HypE)
PFC_RS02170	COG2271	Major facilitator Superfamily
PFC_RS02205	COG1980	fructose-bisphosphate aldolase activity
PFC_RS02215	COG0375	protein maturation
PFC_RS02220	COG0489	protein tyrosine kinase activity
PFC_RS02230	COG0746	molybdenum cofactor guanylyltransferase activity
PFC_RS02240	COG1342	Belongs to the UPF0251 family
PFC_RS02360	COG0535	radical SAM domain protein
PFC_RS02370	COG1510	regulation of RNA biosynthetic process
PFC_RS02400	COG2815	serine threonine protein kinase
PFC_RS02400	COG0515	serine threonine protein kinase
PFC_RS02415	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PFC_RS02440	COG1378	Sugar-specific transcriptional regulator TrmB
PFC_RS02465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PFC_RS02465	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFC_RS02470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PFC_RS02480	COG0456	acetyltransferase
PFC_RS02485	COG1129	ABC transporter
PFC_RS02495	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PFC_RS02505	COG0511	ligase activity, forming carbon-carbon bonds
PFC_RS02505	COG5016	pyruvate
PFC_RS02510	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
PFC_RS02540	COG0432	Pfam Uncharacterised protein family UPF0047
PFC_RS02585	COG1151	hydroxylamine reductase activity
PFC_RS02595	COG0426	domain, Protein
PFC_RS02670	COG0778	Nitroreductase
PFC_RS02675	COG2084	Dehydrogenase
PFC_RS02680	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFC_RS02705	COG0450	alkyl hydroperoxide reductase
PFC_RS02755	COG1131	(ABC) transporter
PFC_RS02810	COG2217	Heavy metal translocating P-type atpase
PFC_RS02820	COG1528	Iron-storage protein
PFC_RS02830	COG1132	(ABC) transporter
PFC_RS02835	COG2095	MarC family integral membrane protein
PFC_RS02845	COG0006	proline dipeptidase activity
PFC_RS02855	COG0778	Nitroreductase
PFC_RS02860	COG0426	domain, Protein
PFC_RS02865	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PFC_RS02870	COG1013	pyruvate-flavodoxin oxidoreductase activity
PFC_RS02905	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PFC_RS02925	COG0463	Glycosyl transferase, family 2
PFC_RS02925	COG1216	Glycosyl transferase, family 2
PFC_RS02930	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PFC_RS02935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PFC_RS02995	COG0438	transferase activity, transferring glycosyl groups
PFC_RS03040	COG0438	transferase activity, transferring glycosyl groups
PFC_RS03065	COG0110	maltose O-acetyltransferase activity
PFC_RS03075	COG1216	Glycosyl transferase, family 2
PFC_RS03080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PFC_RS03105	COG0714	Associated with various cellular activities
PFC_RS03155	COG0668	transmembrane transport
PFC_RS03175	COG0123	including yeast histone deacetylase and acetoin utilization protein
PFC_RS03185	COG1102	Psort location Cytoplasmic, score
PFC_RS03210	COG0534	Mate efflux family protein
PFC_RS03215	COG0534	Mate efflux family protein
PFC_RS03220	COG1505	serine-type exopeptidase activity
PFC_RS03225	COG2271	Major facilitator Superfamily
PFC_RS03230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFC_RS03320	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PFC_RS03355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PFC_RS03380	COG1304	FMN binding
PFC_RS03400	COG0084	hydrolase, TatD family'
PFC_RS03405	COG0434	BtpA family
PFC_RS03410	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PFC_RS03435	COG1522	sequence-specific DNA binding
PFC_RS03440	COG0163	prenyltransferase activity
PFC_RS03455	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PFC_RS03460	COG0017	Asparaginyl-tRNA synthetase
PFC_RS03485	COG2226	methyltransferase
PFC_RS03505	COG1131	(ABC) transporter
PFC_RS03555	COG0495	leucyl-tRNA aminoacylation
PFC_RS03570	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
PFC_RS03605	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PFC_RS03640	COG1131	(ABC) transporter
PFC_RS03660	COG1120	ATPase activity
PFC_RS03665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PFC_RS03670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PFC_RS03695	COG0101	tRNA pseudouridine synthase activity
PFC_RS03705	COG1131	(ABC) transporter
PFC_RS03750	COG0105	UTP biosynthetic process
PFC_RS03760	COG1199	ATP-dependent helicase activity
PFC_RS03770	COG0028	Belongs to the TPP enzyme family
PFC_RS03775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PFC_RS03780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PFC_RS03785	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PFC_RS03790	COG0066	3-isopropylmalate dehydratase activity
PFC_RS03795	COG0473	3-isopropylmalate dehydrogenase activity
PFC_RS03800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PFC_RS03805	COG0129	dihydroxy-acid dehydratase activity
PFC_RS03920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PFC_RS03930	COG1013	pyruvate-flavodoxin oxidoreductase activity
PFC_RS03935	COG0674	pyruvate-flavodoxin oxidoreductase activity
PFC_RS03945	COG1013	pyruvate-flavodoxin oxidoreductase activity
PFC_RS03950	COG0674	pyruvate-flavodoxin oxidoreductase activity
PFC_RS03960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PFC_RS03965	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PFC_RS03970	COG0183	Belongs to the thiolase family
PFC_RS03990	COG2431	L-lysine efflux transmembrane transporter activity
PFC_RS04000	COG2096	Adenosyltransferase
PFC_RS04045	COG1515	deoxyribonuclease V activity
PFC_RS04065	COG1063	alcohol dehydrogenase
PFC_RS04100	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PFC_RS04110	COG0601	transmembrane transport
PFC_RS04115	COG0116	Belongs to the methyltransferase superfamily
PFC_RS04115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PFC_RS04125	COG1785	Belongs to the alkaline phosphatase family
PFC_RS04135	COG0573	inorganic phosphate transmembrane transporter activity
PFC_RS04145	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PFC_RS04155	COG0704	Plays a role in the regulation of phosphate uptake
PFC_RS04190	COG0179	Fumarylacetoacetate (FAA) hydrolase
PFC_RS04215	COG1392	Phosphate transport regulator
PFC_RS04230	COG0215	cysteine-tRNA ligase activity
PFC_RS04240	COG0281	malic enzyme
PFC_RS04265	COG1324	tolerance protein
PFC_RS04275	COG0450	alkyl hydroperoxide reductase
PFC_RS04280	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PFC_RS04305	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PFC_RS04315	COG2255	four-way junction helicase activity
PFC_RS04335	COG0563	adenylate kinase activity
PFC_RS04340	COG0343	queuine tRNA-ribosyltransferase activity
PFC_RS04365	COG1201	RNA secondary structure unwinding
PFC_RS04370	COG0527	aspartate kinase activity
PFC_RS04370	COG0460	homoserine dehydrogenase
PFC_RS04375	COG0527	aspartate kinase activity
PFC_RS04380	COG0083	homoserine kinase activity
PFC_RS04390	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PFC_RS04395	COG0126	phosphoglycerate kinase activity
PFC_RS04400	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PFC_RS04400	COG1213	nucleotidyl transferase
PFC_RS04435	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PFC_RS04440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PFC_RS04455	COG0367	asparagine synthase
PFC_RS04475	COG0730	response to heat
PFC_RS04480	COG0312	modulator of DNA gyrase
PFC_RS04485	COG0312	modulator of DNA gyrase
PFC_RS04505	COG1233	COG1233 Phytoene dehydrogenase and related
PFC_RS04510	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PFC_RS04510	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PFC_RS04545	COG4133	protoheme IX ABC transporter activity
PFC_RS04600	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PFC_RS04605	COG0142	geranyltranstransferase activity
PFC_RS04610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PFC_RS04615	COG0460	homoserine dehydrogenase
PFC_RS04615	COG0527	aspartate kinase activity
PFC_RS04620	COG1335	isochorismatase
PFC_RS04675	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PFC_RS04675	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PFC_RS04685	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PFC_RS04690	COG1518	maintenance of DNA repeat elements
PFC_RS04700	COG1203	CRISPR-associated helicase, Cas3
PFC_RS04760	COG2192	nodulation
PFC_RS04770	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PFC_RS04775	COG0501	Belongs to the peptidase M48B family
PFC_RS04785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PFC_RS04800	COG1185	polyribonucleotide nucleotidyltransferase activity
PFC_RS04825	COG0489	protein tyrosine kinase activity
PFC_RS04835	COG0651	ATP synthesis coupled electron transport
PFC_RS04850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PFC_RS04850	COG2111	Na H antiporter
PFC_RS04855	COG1320	monovalent cation:proton antiporter activity
PFC_RS04860	COG2212	antiporter activity
PFC_RS04865	COG1863	multisubunit Na H antiporter MnhE subunit
PFC_RS04870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PFC_RS04880	COG1850	ribulose-bisphosphate carboxylase activity
PFC_RS04895	COG0076	glutamate decarboxylase activity
PFC_RS04915	COG0589	response to stress
PFC_RS04915	COG0475	glutathione-regulated potassium exporter activity
PFC_RS04960	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFC_RS04965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PFC_RS04965	COG2050	protein possibly involved in aromatic compounds catabolism
PFC_RS04985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PFC_RS04990	COG0306	phosphate transporter
PFC_RS05000	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PFC_RS05025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PFC_RS05030	COG0446	pyridine nucleotide-disulphide oxidoreductase
PFC_RS05040	COG0469	pyruvate kinase activity
PFC_RS05065	COG0735	belongs to the Fur family
PFC_RS05080	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PFC_RS05085	COG1489	DNA binding
PFC_RS05105	COG2414	aldehyde ferredoxin oxidoreductase
PFC_RS05110	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PFC_RS05130	COG2723	6-phospho-beta-galactosidase activity
PFC_RS05140	COG0601	transmembrane transport
PFC_RS05145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFC_RS05150	COG4608	Belongs to the ABC transporter superfamily
PFC_RS05155	COG4608	Belongs to the ABC transporter superfamily
PFC_RS05180	COG2046	Belongs to the sulfate adenylyltransferase family
PFC_RS05185	COG2046	Belongs to the sulfate adenylyltransferase family
PFC_RS05215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PFC_RS05225	COG1522	sequence-specific DNA binding
PFC_RS05245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PFC_RS05250	COG1993	acr, cog1993
PFC_RS05260	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
PFC_RS05280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PFC_RS05285	COG0243	molybdopterin cofactor binding
PFC_RS05335	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PFC_RS05335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFC_RS05340	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PFC_RS05385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFC_RS05385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PFC_RS05390	COG0626	cystathionine gamma-synthase activity
PFC_RS05425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PFC_RS05430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PFC_RS05435	COG1984	allophanate hydrolase subunit 2
PFC_RS05450	COG0602	queuosine metabolic process
PFC_RS05470	COG2033	superoxide reductase activity
PFC_RS05475	COG1773	rubredoxin
PFC_RS05480	COG1592	Rubrerythrin
PFC_RS05490	COG0719	Fe-S assembly protein
PFC_RS05500	COG0396	ATPase activity
PFC_RS05505	COG0301	tRNA thio-modification
PFC_RS05510	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PFC_RS05530	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PFC_RS05545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PFC_RS05555	COG1525	nuclease
PFC_RS05560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PFC_RS05630	COG0758	DNA mediated transformation
PFC_RS05670	COG1598	PFAM Uncharacterised protein family UPF0150
PFC_RS05695	COG0493	'glutamate synthase
PFC_RS05695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PFC_RS05700	COG0543	2 iron, 2 sulfur cluster binding
PFC_RS05710	COG0543	2 iron, 2 sulfur cluster binding
PFC_RS05720	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PFC_RS05725	COG0351	phosphomethylpyrimidine kinase
PFC_RS05730	COG0352	thiamine-phosphate diphosphorylase activity
PFC_RS05735	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PFC_RS05750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PFC_RS05765	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PFC_RS05775	COG0006	proline dipeptidase activity
PFC_RS05780	COG3473	Maleate cis-trans isomerase
PFC_RS05785	COG1234	tRNA 3'-trailer cleavage
PFC_RS05805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PFC_RS05815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PFC_RS05835	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PFC_RS05840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PFC_RS05860	COG1215	transferase activity, transferring glycosyl groups
PFC_RS05870	COG0438	transferase activity, transferring glycosyl groups
PFC_RS05875	COG0297	glycogen (starch) synthase activity
PFC_RS05885	COG0438	transferase activity, transferring glycosyl groups
PFC_RS05915	COG1126	abc transporter atp-binding protein
PFC_RS05920	COG0697	spore germination
PFC_RS05940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PFC_RS05945	COG0095	Lipoate-protein ligase
PFC_RS05950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PFC_RS05955	COG0051	transcription antitermination factor activity, RNA binding
PFC_RS05980	COG0018	arginyl-trna synthetase
PFC_RS05990	COG0371	Dehydrogenase
PFC_RS06010	COG1573	uracil-dna glycosylase
PFC_RS06025	COG1765	OsmC-like protein
PFC_RS06045	COG1293	RNA-binding protein homologous to eukaryotic snRNP
PFC_RS06050	COG1543	Belongs to the glycosyl hydrolase 57 family
PFC_RS06055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PFC_RS06065	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PFC_RS06090	COG1047	Peptidyl-prolyl cis-trans
PFC_RS06105	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PFC_RS06110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PFC_RS06120	COG0528	UMP kinase activity
PFC_RS06125	COG0747	negative chemotaxis
PFC_RS06130	COG0601	transmembrane transport
PFC_RS06135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PFC_RS06140	COG0444	Belongs to the ABC transporter superfamily
PFC_RS06145	COG4608	Belongs to the ABC transporter superfamily
PFC_RS06160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PFC_RS06180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PFC_RS06185	COG0492	ferredoxin-NADP+ reductase activity
PFC_RS06190	COG1863	multisubunit Na H antiporter MnhE subunit
PFC_RS06195	COG2212	antiporter activity
PFC_RS06200	COG1320	monovalent cation:proton antiporter activity
PFC_RS06220	COG1006	Multisubunit Na H antiporter MnhC subunit
PFC_RS06225	COG0651	ATP synthesis coupled electron transport
PFC_RS06235	COG3260	NADH ubiquinone oxidoreductase 20
PFC_RS06240	COG3261	NADH dehydrogenase
PFC_RS06240	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
PFC_RS06250	COG0650	Formate hydrogenlyase subunit 4
PFC_RS06270	COG4818	TM2 domain
PFC_RS06275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PFC_RS06285	COG0649	NAD binding
PFC_RS06295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PFC_RS06305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PFC_RS06310	COG0651	ATP synthesis coupled electron transport
PFC_RS06315	COG0651	ATP synthesis coupled electron transport
PFC_RS06320	COG1006	Multisubunit Na H antiporter MnhC subunit
PFC_RS06335	COG1320	monovalent cation:proton antiporter activity
PFC_RS06340	COG2212	antiporter activity
PFC_RS06345	COG1863	multisubunit Na H antiporter MnhE subunit
PFC_RS06350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PFC_RS06385	COG0252	asparaginase activity
PFC_RS06390	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PFC_RS06415	COG1131	(ABC) transporter
PFC_RS06425	COG1301	dicarboxylic acid transport
PFC_RS06440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PFC_RS06465	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PFC_RS06465	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PFC_RS06475	COG0493	'glutamate synthase
PFC_RS06475	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
PFC_RS06480	COG2414	aldehyde ferredoxin oxidoreductase
PFC_RS06525	COG0301	tRNA thio-modification
PFC_RS06550	COG0509	glycine decarboxylation via glycine cleavage system
PFC_RS06565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PFC_RS06575	COG0436	Aminotransferase
PFC_RS06625	COG1201	RNA secondary structure unwinding
PFC_RS06640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PFC_RS06680	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PFC_RS06680	COG0519	Catalyzes the synthesis of GMP from XMP
PFC_RS06685	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PFC_RS06685	COG0519	Catalyzes the synthesis of GMP from XMP
PFC_RS06695	COG4143	(ABC) transporter
PFC_RS06700	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PFC_RS06705	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
PFC_RS06710	COG3383	formate dehydrogenase (NAD+) activity
PFC_RS06745	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PFC_RS06755	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
PFC_RS06760	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PFC_RS06765	COG0446	pyridine nucleotide-disulphide oxidoreductase
PFC_RS06775	COG0330	HflC and HflK could
PFC_RS06780	COG0058	SHG alpha-glucan phosphorylase activity
PFC_RS06785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PFC_RS06785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PFC_RS06795	COG0402	S-adenosylhomocysteine deaminase activity
PFC_RS06800	COG0167	dihydroorotate dehydrogenase activity
PFC_RS06805	COG0045	succinate-CoA ligase (ADP-forming) activity
PFC_RS06805	COG1042	CoA-binding domain protein
PFC_RS06805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PFC_RS06820	COG1522	sequence-specific DNA binding
PFC_RS06830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PFC_RS06855	COG0430	RNA-3'-phosphate cyclase activity
PFC_RS06875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
PFC_RS06875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFC_RS06885	COG0585	pseudouridine synthase activity
PFC_RS06895	COG0589	response to stress
PFC_RS06900	COG0049	tRNA binding
PFC_RS06920	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PFC_RS06925	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PFC_RS06930	COG0085	RNA polymerase activity
PFC_RS06960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PFC_RS06965	COG1185	polyribonucleotide nucleotidyltransferase activity
PFC_RS06990	COG0312	modulator of DNA gyrase
PFC_RS07020	COG2205	protein histidine kinase activity
PFC_RS07040	COG0616	signal peptide processing
PFC_RS07050	COG0628	permease
PFC_RS07085	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PFC_RS07095	COG1216	Glycosyl transferase, family 2
PFC_RS07110	COG0501	Belongs to the peptidase M48B family
PFC_RS07115	COG2131	deaminase
PFC_RS07120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PFC_RS07130	COG1522	sequence-specific DNA binding
PFC_RS07135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PFC_RS07150	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PFC_RS07165	COG1606	tRNA processing
PFC_RS07170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PFC_RS07175	COG1394	ATPase activity, coupled to movement of substances
PFC_RS07180	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
PFC_RS07185	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
PFC_RS07200	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
PFC_RS07210	COG1269	ATP hydrolysis coupled proton transport
PFC_RS07225	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PFC_RS07235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PFC_RS07250	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PFC_RS07250	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PFC_RS07260	COG0750	zinc metalloprotease
PFC_RS07275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PFC_RS07300	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PFC_RS07310	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PFC_RS07320	COG0017	Asparaginyl-tRNA synthetase
PFC_RS07325	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PFC_RS07330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PFC_RS07350	COG1028	Short-chain dehydrogenase reductase Sdr
PFC_RS07385	COG1446	asparaginase
PFC_RS07395	COG2814	Major facilitator Superfamily
PFC_RS07410	COG2226	methyltransferase
PFC_RS07460	COG2095	MarC family integral membrane protein
PFC_RS07475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PFC_RS07480	COG0556	nucleotide-excision repair
PFC_RS07490	COG1378	Sugar-specific transcriptional regulator TrmB
PFC_RS07500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PFC_RS07505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PFC_RS07530	COG3842	ATPase activity
PFC_RS07535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PFC_RS07540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PFC_RS07545	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PFC_RS07565	COG0697	spore germination
PFC_RS07570	COG0235	Class ii aldolase
PFC_RS07595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PFC_RS07605	COG0314	molybdopterin synthase activity
PFC_RS07640	COG2255	four-way junction helicase activity
PFC_RS07645	COG2255	four-way junction helicase activity
PFC_RS07655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PFC_RS07665	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PFC_RS07670	COG2239	Acts as a magnesium transporter
PFC_RS07675	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PFC_RS07685	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PFC_RS07690	COG3842	ATPase activity
PFC_RS07700	COG0725	ABC transporter, periplasmic molybdate-binding protein
PFC_RS07705	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
PFC_RS07715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PFC_RS07715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PFC_RS07730	COG4221	oxidoreductase activity
PFC_RS07770	COG1122	ATPase activity
PFC_RS07785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PFC_RS07785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PFC_RS07790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PFC_RS07795	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PFC_RS07795	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PFC_RS07800	COG0307	riboflavin synthase, alpha
PFC_RS07820	COG0463	Glycosyl transferase, family 2
PFC_RS07825	COG2234	aminopeptidase activity
PFC_RS07865	COG0270	DNA (cytosine-5-)-methyltransferase activity
PFC_RS07870	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PFC_RS07890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PFC_RS07895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PFC_RS07895	COG0574	Belongs to the PEP-utilizing enzyme family
PFC_RS07920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PFC_RS07970	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PFC_RS07985	COG2379	hydroxypyruvate reductase
PFC_RS08000	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PFC_RS08005	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PFC_RS08030	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PFC_RS08045	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
PFC_RS08055	COG2515	1-aminocyclopropane-1-carboxylate deaminase
PFC_RS08065	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PFC_RS08080	COG1131	(ABC) transporter
PFC_RS08085	COG1121	(ABC) transporter
PFC_RS08165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PFC_RS08190	COG1694	Mazg nucleotide pyrophosphohydrolase
PFC_RS08195	COG0640	Transcriptional regulator
PFC_RS08225	COG0252	asparaginase activity
PFC_RS08240	COG0297	glycogen (starch) synthase activity
PFC_RS08250	COG1628	Protein of unknown function DUF99
PFC_RS08285	COG0598	Magnesium transport protein CorA
PFC_RS08305	COG1757	Na H antiporter
PFC_RS08350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PFC_RS08390	COG0483	inositol monophosphate 1-phosphatase activity
PFC_RS08400	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PFC_RS08430	COG0446	pyridine nucleotide-disulphide oxidoreductase
PFC_RS08435	COG0579	oxidoreductase
PFC_RS08445	COG0584	glycerophosphoryl diester phosphodiesterase
PFC_RS08450	COG2814	Major facilitator Superfamily
PFC_RS08455	COG1073	alpha beta
PFC_RS08485	COG0717	Belongs to the dCTP deaminase family
PFC_RS08505	COG0081	regulation of translation
PFC_RS08510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PFC_RS08525	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PFC_RS08575	COG2078	PFAM AMMECR1 domain protein
PFC_RS08580	COG0157	Belongs to the NadC ModD family
PFC_RS08585	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PFC_RS08590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PFC_RS08595	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
PFC_RS08615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PFC_RS08615	COG1328	CTP reductase activity
PFC_RS08620	COG3842	ATPase activity
PFC_RS08625	COG3833	ABC-type maltose transport systems, permease component
PFC_RS08670	COG0667	Aldo Keto reductase
PFC_RS08675	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PFC_RS08685	COG0010	Belongs to the arginase family
PFC_RS08690	COG1830	Aldolase
PFC_RS08720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PFC_RS08730	COG0346	lactoylglutathione lyase activity
PFC_RS08740	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PFC_RS08740	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
PFC_RS08785	COG2182	Extracellular solute-binding protein
PFC_RS08790	COG1175	transmembrane transport
PFC_RS08795	COG3833	ABC-type maltose transport systems, permease component
PFC_RS08805	COG3842	ATPase activity
PFC_RS08815	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PFC_RS08820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PFC_RS08830	COG1234	tRNA 3'-trailer cleavage
PFC_RS08860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PFC_RS08885	COG0673	inositol 2-dehydrogenase activity
PFC_RS08890	COG0463	Glycosyl transferase, family 2
PFC_RS08910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PFC_RS08915	COG0543	2 iron, 2 sulfur cluster binding
PFC_RS08920	COG0493	'glutamate synthase
PFC_RS08925	COG1141	Ferredoxin
PFC_RS08960	COG1061	Type III restriction enzyme res subunit
PFC_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
PFC_RS09020	COG0516	GMP reductase activity
PFC_RS09020	COG0517	IMP dehydrogenase activity
PFC_RS09030	COG1131	(ABC) transporter
PFC_RS09060	COG0071	Belongs to the small heat shock protein (HSP20) family
PFC_RS09065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PFC_RS09075	COG1458	PINc domain ribonuclease
PFC_RS09090	COG2144	transferase activity, transferring acyl groups
PFC_RS09120	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
PFC_RS09145	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
PFC_RS09160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PFC_RS09185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PFC_RS09190	COG1122	ATPase activity
PFC_RS09195	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PFC_RS09205	COG0315	cyclic pyranopterin monophosphate synthase activity
PFC_RS09215	COG0493	'glutamate synthase
PFC_RS09225	COG0534	Mate efflux family protein
PFC_RS09230	COG2894	cell division
PFC_RS09240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PFC_RS09250	COG1346	cytolysis
PFC_RS09260	COG1196	nuclear chromosome segregation
PFC_RS09285	COG0504	CTP synthase activity
PFC_RS09295	COG0045	succinate-CoA ligase (ADP-forming) activity
PFC_RS09295	COG1042	CoA-binding domain protein
PFC_RS09295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PFC_RS09305	COG0301	tRNA thio-modification
PFC_RS09320	COG1469	GTP cyclohydrolase I activity
PFC_RS09335	COG1078	dGTPase activity
PFC_RS09345	COG0517	IMP dehydrogenase activity
PFC_RS09345	COG0516	GMP reductase activity
PFC_RS09355	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PFC_RS09365	COG0089	rRNA binding
PFC_RS09375	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PFC_RS09380	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PFC_RS09385	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PFC_RS09390	COG0255	Belongs to the universal ribosomal protein uL29 family
PFC_RS09405	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PFC_RS09410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PFC_RS09425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PFC_RS09435	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PFC_RS09440	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PFC_RS09455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PFC_RS09460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PFC_RS09470	COG0200	Binds to the 23S rRNA
PFC_RS09490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PFC_RS09510	COG1476	TRANSCRIPTIONal
PFC_RS09535	COG0546	phosphoglycolate phosphatase activity
PFC_RS09555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PFC_RS09565	COG0303	'Molybdopterin
PFC_RS09575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PFC_RS09585	COG1121	(ABC) transporter
PFC_RS09590	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PFC_RS09595	COG1011	Hydrolase
PFC_RS09610	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PFC_RS09620	COG1013	pyruvate-flavodoxin oxidoreductase activity
PFC_RS09625	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PFC_RS09625	COG0674	pyruvate-flavodoxin oxidoreductase activity
PFC_RS09635	COG1013	pyruvate-flavodoxin oxidoreductase activity
PFC_RS09640	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PFC_RS09640	COG0674	pyruvate-flavodoxin oxidoreductase activity
PFC_RS09655	COG1872	DUF167
PFC_RS09660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PFC_RS09665	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PFC_RS09690	COG0037	tRNA processing
PFC_RS09700	COG0393	Putative heavy-metal-binding
PFC_RS09720	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PFC_RS09720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PFC_RS09730	COG4143	(ABC) transporter
PFC_RS09735	COG3842	ATPase activity
PFC_RS09760	COG3842	ATPase activity
PFC_RS09770	COG0438	transferase activity, transferring glycosyl groups
PFC_RS09785	COG1653	transport
PFC_RS09820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PFC_RS09825	COG1522	sequence-specific DNA binding
PFC_RS09840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PFC_RS09845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PFC_RS09855	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PFC_RS09880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PFC_RS09900	COG0693	protein deglycase activity
PFC_RS09920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PFC_RS09930	COG0505	Belongs to the CarA family
PFC_RS09945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PFC_RS09950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PFC_RS09955	COG0512	Glutamine amidotransferase of anthranilate synthase
PFC_RS09960	COG0135	phosphoribosylanthranilate isomerase activity
PFC_RS09965	COG0133	tryptophan synthase activity
PFC_RS09970	COG0159	tryptophan synthase activity
PFC_RS09985	COG0436	Aminotransferase
PFC_RS09990	COG0077	Prephenate dehydratase
PFC_RS09990	COG1605	Chorismate mutase
PFC_RS10000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PFC_RS10005	COG1079	Belongs to the binding-protein-dependent transport system permease family
PFC_RS10010	COG4603	Belongs to the binding-protein-dependent transport system permease family
PFC_RS10015	COG3845	ABC transporter
PFC_RS10020	COG1744	ABC transporter substrate-binding protein PnrA-like
PFC_RS10025	COG0083	homoserine kinase activity
PFC_RS10030	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PFC_RS10035	COG0710	3-dehydroquinate dehydratase activity
PFC_RS10040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PFC_RS10045	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PFC_RS10050	COG3958	Transketolase
PFC_RS10065	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PFC_RS10070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PFC_RS10075	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PFC_RS10080	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PFC_RS10085	COG0189	ligase activity
PFC_RS10095	COG0066	3-isopropylmalate dehydratase activity
PFC_RS10100	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PFC_RS10105	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PFC_RS10110	COG1268	BioY protein
PFC_RS10115	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PFC_RS10115	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PFC_RS10120	COG1794	racemase activity, acting on amino acids and derivatives
PFC_RS10155	COG1404	Belongs to the peptidase S8 family
PFC_RS10170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PFC_RS10170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PFC_RS10180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PFC_RS10185	COG0140	phosphoribosyl-ATP diphosphatase activity
PFC_RS10185	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PFC_RS10190	COG0107	imidazoleglycerol-phosphate synthase activity
PFC_RS10195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PFC_RS10200	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PFC_RS10215	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PFC_RS10220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PFC_RS10225	COG0778	Nitroreductase
PFC_RS10230	COG1132	(ABC) transporter
PFC_RS10235	COG1132	(ABC) transporter
PFC_RS10255	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PFC_RS10260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PFC_RS10270	COG0202	RNA polymerase activity
PFC_RS10285	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PFC_RS10290	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PFC_RS10310	COG0148	phosphopyruvate hydratase activity
PFC_RS10315	COG0052	Belongs to the universal ribosomal protein uS2 family
PFC_RS10320	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PFC_RS10325	COG1355	regulation of microtubule-based process
PFC_RS10330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PFC_RS10335	COG0528	UMP kinase activity
PFC_RS10360	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
PFC_RS10375	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PFC_RS10380	COG0423	glycine-tRNA ligase activity
PFC_RS10405	COG0482	sulfurtransferase activity
PFC_RS10425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PFC_RS10465	COG2894	cell division
PFC_RS10485	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PFC_RS10490	COG1216	Glycosyl transferase, family 2
PFC_RS10630	COG1404	Belongs to the peptidase S8 family
PFC_RS10715	COG2723	6-phospho-beta-galactosidase activity
PFC_RS10835	COG2813	Specifically methylates the guanine in position