locus-tag	class	description
PYRFU_RS00020	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PYRFU_RS00030	COG0037	tRNA processing
PYRFU_RS00050	COG0463	Glycosyl transferase, family 2
PYRFU_RS00055	COG4133	protoheme IX ABC transporter activity
PYRFU_RS00060	COG1458	PINc domain ribonuclease
PYRFU_RS00065	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PYRFU_RS00065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PYRFU_RS00085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PYRFU_RS00090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PYRFU_RS00120	COG0492	ferredoxin-NADP+ reductase activity
PYRFU_RS00185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PYRFU_RS00190	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PYRFU_RS00235	COG1213	nucleotidyl transferase
PYRFU_RS00235	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PYRFU_RS00270	COG0569	domain protein
PYRFU_RS00270	COG0475	glutathione-regulated potassium exporter activity
PYRFU_RS00315	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PYRFU_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
PYRFU_RS00360	COG2062	phosphohistidine phosphatase, SixA
PYRFU_RS00365	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PYRFU_RS00395	COG0493	'glutamate synthase
PYRFU_RS00400	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PYRFU_RS00440	COG0494	nUDIX hydrolase
PYRFU_RS00460	COG1534	Rna-binding protein
PYRFU_RS00525	COG0343	queuine tRNA-ribosyltransferase activity
PYRFU_RS00540	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PYRFU_RS00545	COG0459	protein refolding
PYRFU_RS00565	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PYRFU_RS00575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PYRFU_RS00580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PYRFU_RS00580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PYRFU_RS00590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PYRFU_RS00605	COG0585	pseudouridine synthase activity
PYRFU_RS00635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PYRFU_RS00670	COG1234	tRNA 3'-trailer cleavage
PYRFU_RS00675	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PYRFU_RS00685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PYRFU_RS00705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PYRFU_RS00715	COG0509	glycine decarboxylation via glycine cleavage system
PYRFU_RS00725	COG1573	uracil-dna glycosylase
PYRFU_RS00750	COG0175	sulfate reduction
PYRFU_RS00770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PYRFU_RS00800	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
PYRFU_RS00820	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PYRFU_RS00875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PYRFU_RS00880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PYRFU_RS00910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PYRFU_RS00915	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
PYRFU_RS00920	COG0116	Belongs to the methyltransferase superfamily
PYRFU_RS00925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PYRFU_RS00995	COG1185	polyribonucleotide nucleotidyltransferase activity
PYRFU_RS01045	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PYRFU_RS01050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PYRFU_RS01060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PYRFU_RS01060	COG0517	IMP dehydrogenase activity
PYRFU_RS01075	COG1515	deoxyribonuclease V activity
PYRFU_RS01090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PYRFU_RS01095	COG0430	RNA-3'-phosphate cyclase activity
PYRFU_RS01120	COG1047	Peptidyl-prolyl cis-trans
PYRFU_RS01125	COG0371	Dehydrogenase
PYRFU_RS01130	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PYRFU_RS01135	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PYRFU_RS01140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PYRFU_RS01160	COG0085	RNA polymerase activity
PYRFU_RS01165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PYRFU_RS01170	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PYRFU_RS01175	COG1358	cellular component organization or biogenesis
PYRFU_RS01195	COG0049	tRNA binding
PYRFU_RS01200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PYRFU_RS01205	COG0051	transcription antitermination factor activity, RNA binding
PYRFU_RS01215	COG0450	alkyl hydroperoxide reductase
PYRFU_RS01230	COG0438	transferase activity, transferring glycosyl groups
PYRFU_RS01235	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PYRFU_RS01250	COG1522	sequence-specific DNA binding
PYRFU_RS01280	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PYRFU_RS01285	COG0314	molybdopterin synthase activity
PYRFU_RS01310	COG0495	leucyl-tRNA aminoacylation
PYRFU_RS01315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PYRFU_RS01390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PYRFU_RS01410	COG3259	Nickel-dependent hydrogenase
PYRFU_RS01430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PYRFU_RS01460	COG1966	Carbon starvation protein
PYRFU_RS01475	COG0003	Pfam Anion-transporting ATPase
PYRFU_RS01485	COG0154	amidase activity
PYRFU_RS01495	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PYRFU_RS01575	COG1201	RNA secondary structure unwinding
PYRFU_RS01620	COG2217	Heavy metal translocating P-type atpase
PYRFU_RS01625	COG2033	superoxide reductase activity
PYRFU_RS01635	COG0426	domain, Protein
PYRFU_RS01885	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
PYRFU_RS01890	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PYRFU_RS01900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
PYRFU_RS01910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PYRFU_RS01920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PYRFU_RS01930	COG4149	molybdate abc transporter
PYRFU_RS01935	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PYRFU_RS01940	COG0151	Belongs to the GarS family
PYRFU_RS01950	COG2095	MarC family integral membrane protein
PYRFU_RS01990	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PYRFU_RS01995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PYRFU_RS02025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PYRFU_RS02045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PYRFU_RS02070	COG2046	Belongs to the sulfate adenylyltransferase family
PYRFU_RS02080	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PYRFU_RS02125	COG1136	(ABC) transporter
PYRFU_RS02125	COG0577	efflux transmembrane transporter activity
PYRFU_RS02130	COG1136	(ABC) transporter
PYRFU_RS02165	COG4139	cobalamin transport
PYRFU_RS02170	COG1120	ATPase activity
PYRFU_RS02375	COG1131	(ABC) transporter
PYRFU_RS02750	COG0309	Hydrogenase expression formation protein (HypE)
PYRFU_RS02760	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
PYRFU_RS02780	COG2309	aminopeptidase activity
PYRFU_RS02785	COG1444	tRNA N-acetyltransferase activity
PYRFU_RS02820	COG1968	undecaprenyl-diphosphatase activity
PYRFU_RS02840	COG0535	radical SAM domain protein
PYRFU_RS02925	COG1489	DNA binding
PYRFU_RS02960	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
PYRFU_RS02975	COG0436	Aminotransferase
PYRFU_RS02980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PYRFU_RS03010	COG0717	Belongs to the dCTP deaminase family
PYRFU_RS03015	COG0135	phosphoribosylanthranilate isomerase activity
PYRFU_RS03100	COG0717	Belongs to the dCTP deaminase family
PYRFU_RS03125	COG1234	tRNA 3'-trailer cleavage
PYRFU_RS03145	COG0504	CTP synthase activity
PYRFU_RS03155	COG0529	Catalyzes the synthesis of activated sulfate
PYRFU_RS03160	COG0017	Asparaginyl-tRNA synthetase
PYRFU_RS03170	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PYRFU_RS03175	COG1122	ATPase activity
PYRFU_RS03190	COG0310	cobalt ion transport
PYRFU_RS03200	COG1110	DNA topoisomerase II activity
PYRFU_RS03255	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PYRFU_RS03275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PYRFU_RS03285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PYRFU_RS03295	COG0243	molybdopterin cofactor binding
PYRFU_RS03300	COG1151	hydroxylamine reductase activity
PYRFU_RS03315	COG0275	rRNA processing
PYRFU_RS03330	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PYRFU_RS03335	COG1215	transferase activity, transferring glycosyl groups
PYRFU_RS03395	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PYRFU_RS03395	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PYRFU_RS03400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PYRFU_RS03405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PYRFU_RS03415	COG1061	Type III restriction enzyme res subunit
PYRFU_RS03425	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
PYRFU_RS03440	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PYRFU_RS03455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PYRFU_RS03465	COG0626	cystathionine gamma-synthase activity
PYRFU_RS03470	COG0083	homoserine kinase activity
PYRFU_RS03475	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PYRFU_RS03485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PYRFU_RS03490	COG1013	pyruvate-flavodoxin oxidoreductase activity
PYRFU_RS03495	COG0674	pyruvate-flavodoxin oxidoreductase activity
PYRFU_RS03505	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PYRFU_RS03510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PYRFU_RS03535	COG0023	Translation Initiation Factor
PYRFU_RS03545	COG0010	Belongs to the arginase family
PYRFU_RS03605	COG0409	Hydrogenase expression formation protein
PYRFU_RS03610	COG0095	Lipoate-protein ligase
PYRFU_RS03645	COG0189	ligase activity
PYRFU_RS03665	COG0066	3-isopropylmalate dehydratase activity
PYRFU_RS03710	COG0165	Argininosuccinate lyase
PYRFU_RS03715	COG0505	Belongs to the CarA family
PYRFU_RS03725	COG0189	ligase activity
PYRFU_RS03735	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PYRFU_RS03755	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
PYRFU_RS03770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PYRFU_RS03800	COG1444	tRNA N-acetyltransferase activity
PYRFU_RS03810	COG1051	belongs to the nudix hydrolase family
PYRFU_RS03820	COG0602	queuosine metabolic process
PYRFU_RS03860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PYRFU_RS03880	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PYRFU_RS03895	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
PYRFU_RS03905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PYRFU_RS03910	COG4608	Belongs to the ABC transporter superfamily
PYRFU_RS03930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PYRFU_RS03985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PYRFU_RS03985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PYRFU_RS03995	COG0720	synthase
PYRFU_RS04005	COG0318	PFAM AMP-dependent synthetase and ligase
PYRFU_RS04015	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PYRFU_RS04025	COG0442	prolyl-tRNA aminoacylation
PYRFU_RS04055	COG0519	Catalyzes the synthesis of GMP from XMP
PYRFU_RS04100	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PYRFU_RS04105	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PYRFU_RS04115	COG0084	hydrolase, TatD family'
PYRFU_RS04120	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PYRFU_RS04125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PYRFU_RS04195	COG0301	tRNA thio-modification
PYRFU_RS04210	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
PYRFU_RS04225	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
PYRFU_RS04240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PYRFU_RS04245	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PYRFU_RS04285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PYRFU_RS04285	COG0574	Belongs to the PEP-utilizing enzyme family
PYRFU_RS04305	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
PYRFU_RS04310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PYRFU_RS04315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PYRFU_RS04325	COG3845	ABC transporter
PYRFU_RS04330	COG4603	Belongs to the binding-protein-dependent transport system permease family
PYRFU_RS04335	COG1079	Belongs to the binding-protein-dependent transport system permease family
PYRFU_RS04365	COG1078	dGTPase activity
PYRFU_RS04390	COG3833	ABC-type maltose transport systems, permease component
PYRFU_RS04395	COG3842	ATPase activity
PYRFU_RS04415	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PYRFU_RS04420	COG0149	triose-phosphate isomerase activity
PYRFU_RS04430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
PYRFU_RS04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PYRFU_RS04475	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PYRFU_RS04495	COG0584	glycerophosphoryl diester phosphodiesterase
PYRFU_RS04500	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PYRFU_RS04505	COG1993	acr, cog1993
PYRFU_RS04535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PYRFU_RS04540	COG1355	regulation of microtubule-based process
PYRFU_RS04550	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
PYRFU_RS04555	COG1304	FMN binding
PYRFU_RS04570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PYRFU_RS04585	COG0109	protoheme IX farnesyltransferase activity
PYRFU_RS04595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PYRFU_RS04610	COG0105	UTP biosynthetic process
PYRFU_RS04625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PYRFU_RS04645	COG1716	ATPase activity
PYRFU_RS04670	COG0024	Methionine aminopeptidase
PYRFU_RS04700	COG0601	transmembrane transport
PYRFU_RS04720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PYRFU_RS04725	COG0813	purine-nucleoside phosphorylase activity
PYRFU_RS04755	COG0301	tRNA thio-modification
PYRFU_RS04770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PYRFU_RS04775	COG0252	asparaginase activity
PYRFU_RS04790	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PYRFU_RS04790	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PYRFU_RS04800	COG1110	DNA topoisomerase II activity
PYRFU_RS04855	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PYRFU_RS04860	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PYRFU_RS04865	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PYRFU_RS04875	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PYRFU_RS04905	COG0552	protein localization to endoplasmic reticulum
PYRFU_RS04920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PYRFU_RS04930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PYRFU_RS04975	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PYRFU_RS04980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PYRFU_RS05000	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PYRFU_RS05010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PYRFU_RS05125	COG1702	phosphate starvation-inducible protein PhoH
PYRFU_RS05135	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PYRFU_RS05140	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PYRFU_RS05145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PYRFU_RS05150	COG0512	Glutamine amidotransferase of anthranilate synthase
PYRFU_RS05160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PYRFU_RS05170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
PYRFU_RS05175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PYRFU_RS05175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PYRFU_RS05195	COG0714	Associated with various cellular activities
PYRFU_RS05220	COG0052	Belongs to the universal ribosomal protein uS2 family
PYRFU_RS05235	COG0010	Belongs to the arginase family
PYRFU_RS05245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PYRFU_RS05250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PYRFU_RS05270	COG0473	3-isopropylmalate dehydrogenase activity
PYRFU_RS05350	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PYRFU_RS05350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PYRFU_RS05360	COG2078	PFAM AMMECR1 domain protein
PYRFU_RS05360	COG3885	ferrous iron binding
PYRFU_RS05385	COG1063	alcohol dehydrogenase
PYRFU_RS05390	COG0243	molybdopterin cofactor binding
PYRFU_RS05405	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
PYRFU_RS05410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PYRFU_RS05430	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PYRFU_RS05485	COG2217	Heavy metal translocating P-type atpase
PYRFU_RS05535	COG0004	ammonium transporteR
PYRFU_RS05540	COG0347	Belongs to the P(II) protein family
PYRFU_RS05555	COG1125	glycine betaine transport
PYRFU_RS05555	COG0517	IMP dehydrogenase activity
PYRFU_RS05560	COG0667	Aldo Keto reductase
PYRFU_RS05590	COG1028	Short-chain dehydrogenase reductase Sdr
PYRFU_RS05640	COG0084	hydrolase, TatD family'
PYRFU_RS05690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PYRFU_RS05695	COG0746	molybdenum cofactor guanylyltransferase activity
PYRFU_RS05700	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
PYRFU_RS05750	COG0515	serine threonine protein kinase
PYRFU_RS05875	COG2002	toxin-antitoxin pair type II binding
PYRFU_RS05935	COG0589	response to stress
PYRFU_RS05945	COG0516	GMP reductase activity
PYRFU_RS05945	COG0517	IMP dehydrogenase activity
PYRFU_RS05975	COG0045	succinate-CoA ligase (ADP-forming) activity
PYRFU_RS06020	COG1196	nuclear chromosome segregation
PYRFU_RS06070	COG2255	four-way junction helicase activity
PYRFU_RS06215	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PYRFU_RS06240	COG0674	pyruvate-flavodoxin oxidoreductase activity
PYRFU_RS06260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PYRFU_RS06275	COG0301	tRNA thio-modification
PYRFU_RS06275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PYRFU_RS06300	COG0126	phosphoglycerate kinase activity
PYRFU_RS06320	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PYRFU_RS06330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PYRFU_RS06340	COG4962	Type ii secretion system protein e
PYRFU_RS06350	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PYRFU_RS06360	COG0124	histidyl-tRNA synthetase
PYRFU_RS06370	COG1444	tRNA N-acetyltransferase activity
PYRFU_RS06375	COG0322	excinuclease ABC activity
PYRFU_RS06410	COG0372	Belongs to the citrate synthase family
PYRFU_RS06425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PYRFU_RS06430	COG0704	Plays a role in the regulation of phosphate uptake
PYRFU_RS06435	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PYRFU_RS06440	COG0460	homoserine dehydrogenase
PYRFU_RS06440	COG0527	aspartate kinase activity
PYRFU_RS06445	COG1342	Belongs to the UPF0251 family
PYRFU_RS06450	COG1444	tRNA N-acetyltransferase activity
PYRFU_RS06475	COG0072	phenylalanine-tRNA ligase activity
PYRFU_RS06490	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PYRFU_RS06520	COG0243	molybdopterin cofactor binding
PYRFU_RS06570	COG0501	Belongs to the peptidase M48B family
PYRFU_RS06580	COG0434	BtpA family
PYRFU_RS06585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
PYRFU_RS06610	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
PYRFU_RS06615	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
PYRFU_RS06630	COG1522	sequence-specific DNA binding
PYRFU_RS06635	COG0535	radical SAM domain protein
PYRFU_RS06640	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PYRFU_RS06645	COG1648	precorrin-2 dehydrogenase activity
PYRFU_RS06645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PYRFU_RS06655	COG0183	Belongs to the thiolase family
PYRFU_RS06660	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PYRFU_RS06670	COG0018	arginyl-trna synthetase
PYRFU_RS06685	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
PYRFU_RS06700	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PYRFU_RS06720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PYRFU_RS06765	COG0113	porphobilinogen synthase activity
PYRFU_RS06770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PYRFU_RS06775	COG0181	hydroxymethylbilane synthase activity
PYRFU_RS06780	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PYRFU_RS06780	COG1587	Uroporphyrinogen-III synthase
PYRFU_RS06795	COG0517	IMP dehydrogenase activity
PYRFU_RS06795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PYRFU_RS06800	COG0047	phosphoribosylformylglycinamidine synthase activity
PYRFU_RS06805	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PYRFU_RS06810	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PYRFU_RS06815	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PYRFU_RS06835	COG0134	indole-3-glycerol-phosphate synthase activity
PYRFU_RS06850	COG0298	carbon dioxide binding
PYRFU_RS06855	COG0528	UMP kinase activity
PYRFU_RS06900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PYRFU_RS06905	COG0009	L-threonylcarbamoyladenylate synthase
PYRFU_RS06930	COG0045	succinate-CoA ligase (ADP-forming) activity
PYRFU_RS06930	COG1042	CoA-binding domain protein
PYRFU_RS06930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PYRFU_RS06980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PYRFU_RS06985	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PYRFU_RS07000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PYRFU_RS07005	COG0805	protein transport
PYRFU_RS07015	COG1250	3-hydroxyacyl-CoA dehydrogenase
PYRFU_RS07045	COG1131	(ABC) transporter
PYRFU_RS07070	COG0516	GMP reductase activity
PYRFU_RS07070	COG0517	IMP dehydrogenase activity
PYRFU_RS07080	COG0396	ATPase activity
PYRFU_RS07085	COG0719	Fe-S assembly protein
PYRFU_RS07095	COG0069	glutamate synthase activity
PYRFU_RS07105	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PYRFU_RS07110	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PYRFU_RS07115	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PYRFU_RS07125	COG0107	imidazoleglycerol-phosphate synthase activity
PYRFU_RS07155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
PYRFU_RS07200	COG0561	phosphatase activity
PYRFU_RS07230	COG3959	Transketolase, thiamine diphosphate binding domain
PYRFU_RS07235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PYRFU_RS07240	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PYRFU_RS07245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PYRFU_RS07265	COG0529	Catalyzes the synthesis of activated sulfate
PYRFU_RS07300	COG0303	'Molybdopterin
PYRFU_RS07345	COG0644	oxidoreductase
PYRFU_RS07380	COG1058	Belongs to the CinA family
PYRFU_RS07380	COG1546	Belongs to the CinA family
PYRFU_RS07385	COG2151	metal-sulfur cluster biosynthetic enzyme
PYRFU_RS07415	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PYRFU_RS07450	COG0167	dihydroorotate dehydrogenase activity
PYRFU_RS07455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PYRFU_RS07460	COG0543	2 iron, 2 sulfur cluster binding
PYRFU_RS07465	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
PYRFU_RS07470	COG0540	Belongs to the ATCase OTCase family
PYRFU_RS07475	COG0284	orotidine-5'-phosphate decarboxylase activity
PYRFU_RS07480	COG1324	tolerance protein
PYRFU_RS07505	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PYRFU_RS07570	COG0109	protoheme IX farnesyltransferase activity
PYRFU_RS07575	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PYRFU_RS07590	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
PYRFU_RS07595	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
PYRFU_RS07600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PYRFU_RS07610	COG0174	glutamine synthetase
PYRFU_RS07630	COG0419	ATPase involved in DNA repair
PYRFU_RS07635	COG0420	3'-5' exonuclease activity
PYRFU_RS07655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PYRFU_RS07670	COG0215	cysteine-tRNA ligase activity
PYRFU_RS07675	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PYRFU_RS07755	COG0444	Belongs to the ABC transporter superfamily
PYRFU_RS07760	COG1397	ADP-ribosylglycohydrolase
PYRFU_RS07805	COG1120	ATPase activity
PYRFU_RS07810	COG2414	aldehyde ferredoxin oxidoreductase
PYRFU_RS07825	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
PYRFU_RS07830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PYRFU_RS07845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PYRFU_RS07865	COG2226	methyltransferase
PYRFU_RS07890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PYRFU_RS07895	COG1193	negative regulation of DNA recombination
PYRFU_RS07965	COG0066	3-isopropylmalate dehydratase activity
PYRFU_RS07990	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PYRFU_RS08035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PYRFU_RS08055	COG1201	RNA secondary structure unwinding
PYRFU_RS08065	COG2171	N-acyltransferase activity
PYRFU_RS08105	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PYRFU_RS08110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PYRFU_RS08120	COG0037	tRNA processing
PYRFU_RS08140	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PYRFU_RS08160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PYRFU_RS08170	COG0089	rRNA binding
PYRFU_RS08175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
PYRFU_RS08180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PYRFU_RS08185	COG0255	Belongs to the universal ribosomal protein uL29 family
PYRFU_RS08195	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PYRFU_RS08215	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PYRFU_RS08220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PYRFU_RS08225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PYRFU_RS08230	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PYRFU_RS08250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PYRFU_RS08260	COG0200	Binds to the 23S rRNA
PYRFU_RS08285	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PYRFU_RS08295	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PYRFU_RS08300	COG0697	spore germination
PYRFU_RS08305	COG2813	Specifically methylates the guanine in position
PYRFU_RS08310	COG0129	dihydroxy-acid dehydratase activity
PYRFU_RS08315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PYRFU_RS08320	COG0028	Belongs to the TPP enzyme family
PYRFU_RS08355	COG0189	ligase activity
PYRFU_RS08360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PYRFU_RS08370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PYRFU_RS08375	COG0423	glycine-tRNA ligase activity
PYRFU_RS08440	COG0417	DNA replication proofreading
PYRFU_RS08450	COG2226	methyltransferase
PYRFU_RS08460	COG0131	Imidazoleglycerol-phosphate dehydratase
PYRFU_RS08480	COG0330	HflC and HflK could
PYRFU_RS08485	COG0740	serine-type endopeptidase activity
PYRFU_RS08505	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PYRFU_RS08510	COG0489	protein tyrosine kinase activity
PYRFU_RS08530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PYRFU_RS08540	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PYRFU_RS08545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PYRFU_RS08545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PYRFU_RS08550	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
PYRFU_RS08565	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PYRFU_RS08570	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PYRFU_RS08590	COG2255	four-way junction helicase activity
PYRFU_RS08600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PYRFU_RS08605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PYRFU_RS08605	COG0519	Catalyzes the synthesis of GMP from XMP
PYRFU_RS08610	COG0519	Catalyzes the synthesis of GMP from XMP
PYRFU_RS08610	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PYRFU_RS08645	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
PYRFU_RS08650	COG1120	ATPase activity
PYRFU_RS08665	COG1980	fructose-bisphosphate aldolase activity
PYRFU_RS08710	COG0037	tRNA processing
PYRFU_RS08735	COG1129	ABC transporter
PYRFU_RS08740	COG4603	Belongs to the binding-protein-dependent transport system permease family
PYRFU_RS08745	COG1079	Belongs to the binding-protein-dependent transport system permease family
PYRFU_RS08785	COG0667	Aldo Keto reductase
PYRFU_RS08790	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PYRFU_RS08795	COG0750	zinc metalloprotease
PYRFU_RS08805	COG0322	excinuclease ABC activity
PYRFU_RS08810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PYRFU_RS08835	COG0180	Tryptophanyl-tRNA synthetase
PYRFU_RS08840	COG0517	IMP dehydrogenase activity
PYRFU_RS08855	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PYRFU_RS08900	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PYRFU_RS08925	COG3481	metal-dependent phosphohydrolase, HD sub domain
PYRFU_RS08955	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PYRFU_RS09020	COG0731	radical SAM domain protein
PYRFU_RS09020	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PYRFU_RS09030	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PYRFU_RS09030	COG0140	phosphoribosyl-ATP diphosphatase activity
PYRFU_RS09060	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PYRFU_RS09080	COG0312	modulator of DNA gyrase
PYRFU_RS09085	COG4948	Mandelate Racemase Muconate Lactonizing
PYRFU_RS09165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PYRFU_RS09185	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
PYRFU_RS09185	COG1618	nucleotide phosphatase activity, acting on free nucleotides
PYRFU_RS09190	COG1007	ATP synthesis coupled electron transport
PYRFU_RS09195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PYRFU_RS09200	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PYRFU_RS09215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PYRFU_RS09230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PYRFU_RS09265	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PYRFU_RS09290	COG1796	DNA polymerase
PYRFU_RS09290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PYRFU_RS09320	COG1131	(ABC) transporter
PYRFU_RS09330	COG0531	amino acid
PYRFU_RS09335	COG0473	3-isopropylmalate dehydrogenase activity
PYRFU_RS09355	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PYRFU_RS09390	COG0668	transmembrane transport
PYRFU_RS09395	COG0612	Peptidase, M16
PYRFU_RS09405	COG4974	Belongs to the 'phage' integrase family
PYRFU_RS09435	COG2342	PFAM TM1410 hypothetical-related protein
PYRFU_RS09515	COG0315	cyclic pyranopterin monophosphate synthase activity
PYRFU_RS09540	COG0148	phosphopyruvate hydratase activity
PYRFU_RS09550	COG0668	transmembrane transport
PYRFU_RS09570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PYRFU_RS09585	COG0459	protein refolding
PYRFU_RS09600	COG2264	protein methyltransferase activity
PYRFU_RS09640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PYRFU_RS09655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
PYRFU_RS09660	COG0649	NAD binding
PYRFU_RS09680	COG1522	sequence-specific DNA binding
PYRFU_RS09690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PYRFU_RS09690	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PYRFU_RS09700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PYRFU_RS09705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PYRFU_RS09710	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PYRFU_RS09715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PYRFU_RS09725	COG1793	dna ligase
PYRFU_RS09740	COG0778	Nitroreductase
PYRFU_RS09750	COG0521	Mo-molybdopterin cofactor biosynthetic process
PYRFU_RS09775	COG1394	ATPase activity, coupled to movement of substances
PYRFU_RS09825	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
PYRFU_RS09845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PYRFU_RS09850	COG0438	transferase activity, transferring glycosyl groups
PYRFU_RS09900	COG2264	protein methyltransferase activity
PYRFU_RS09935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PYRFU_RS09950	COG0813	purine-nucleoside phosphorylase activity
PYRFU_RS09960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
PYRFU_RS09980	COG1063	alcohol dehydrogenase
PYRFU_RS09990	COG0730	response to heat
PYRFU_RS10005	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PYRFU_RS10030	COG0746	molybdenum cofactor guanylyltransferase activity
PYRFU_RS10075	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PYRFU_RS10100	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
PYRFU_RS10185	COG0864	Transcriptional regulator
PYRFU_RS10275	COG3118	belongs to the thioredoxin family