locus-tag	class	description
HG718_RS00045	COG0367	asparagine synthase
HG718_RS00055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HG718_RS00060	COG1088	dTDP-glucose 4,6-dehydratase activity
HG718_RS00080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HG718_RS00105	COG0367	asparagine synthase
HG718_RS00115	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HG718_RS00125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HG718_RS00140	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS00155	COG0405	Gamma-glutamyltransferase
HG718_RS00160	COG3300	MHYT domain
HG718_RS00160	COG5001	Diguanylate cyclase
HG718_RS00165	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
HG718_RS00175	COG0726	polysaccharide deacetylase
HG718_RS00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG718_RS00195	COG0347	Belongs to the P(II) protein family
HG718_RS00205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG718_RS00215	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HG718_RS00220	COG0287	Prephenate dehydrogenase
HG718_RS00250	COG2884	Cell division ATP-binding protein ftsE
HG718_RS00265	COG0019	diaminopimelate decarboxylase activity
HG718_RS00275	COG0165	Argininosuccinate lyase
HG718_RS00280	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG718_RS00290	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG718_RS00300	COG2086	electron transfer activity
HG718_RS00310	COG3655	Transcriptional regulator
HG718_RS00320	COG0596	Alpha beta hydrolase
HG718_RS00370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG718_RS00380	COG0400	carboxylic ester hydrolase activity
HG718_RS00390	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HG718_RS00395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HG718_RS00400	COG3932	Exopolysaccharide synthesis, ExoD
HG718_RS00645	COG1132	(ABC) transporter
HG718_RS00670	COG0425	Belongs to the sulfur carrier protein TusA family
HG718_RS00675	COG0318	PFAM AMP-dependent synthetase and ligase
HG718_RS00690	COG1063	alcohol dehydrogenase
HG718_RS00700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG718_RS00730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG718_RS00750	COG0277	FAD linked oxidase domain protein
HG718_RS00760	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HG718_RS00785	COG1960	acyl-CoA dehydrogenase activity
HG718_RS00790	COG1024	Enoyl-CoA hydratase
HG718_RS00805	COG0385	Bile acid
HG718_RS00815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG718_RS00850	COG4783	chaperone-mediated protein folding
HG718_RS00855	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG718_RS00865	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HG718_RS00880	COG1960	acyl-CoA dehydrogenase activity
HG718_RS00885	COG2205	protein histidine kinase activity
HG718_RS00885	COG2202	Pas domain
HG718_RS00905	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HG718_RS00940	COG4536	flavin adenine dinucleotide binding
HG718_RS00945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HG718_RS00950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG718_RS00965	COG4974	Belongs to the 'phage' integrase family
HG718_RS00975	COG1595	DNA-templated transcription, initiation
HG718_RS00985	COG0825	malonyl-CoA metabolic process
HG718_RS00990	COG0596	Alpha beta hydrolase
HG718_RS00995	COG0596	Alpha beta hydrolase
HG718_RS01010	COG2814	Major facilitator Superfamily
HG718_RS01015	COG0653	protein targeting
HG718_RS01020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG718_RS01025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HG718_RS01030	COG0494	nUDIX hydrolase
HG718_RS01040	COG2226	methyltransferase
HG718_RS01045	COG1040	competence protein
HG718_RS01050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HG718_RS01055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HG718_RS01065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG718_RS01070	COG0527	aspartate kinase activity
HG718_RS01075	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG718_RS01085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HG718_RS01090	COG2890	protein-(glutamine-N5) methyltransferase activity
HG718_RS01105	COG0542	response to heat
HG718_RS01115	COG0739	heme binding
HG718_RS01150	COG0778	Nitroreductase
HG718_RS01155	COG0583	DNA-binding transcription factor activity
HG718_RS01160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG718_RS01165	COG2910	NAD(P)H-binding
HG718_RS01170	COG0659	secondary active sulfate transmembrane transporter activity
HG718_RS01175	COG0589	response to stress
HG718_RS01225	COG0367	asparagine synthase
HG718_RS01230	COG0500	methyltransferase
HG718_RS01235	COG1216	Glycosyl transferase, family 2
HG718_RS01250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HG718_RS01255	COG2079	MmgE PrpD family protein
HG718_RS01265	COG2197	response regulator
HG718_RS01305	COG0175	sulfate reduction
HG718_RS01315	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HG718_RS01345	COG0579	oxidoreductase
HG718_RS01365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HG718_RS01375	COG2951	lytic endotransglycosylase activity
HG718_RS01385	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG718_RS01385	COG1024	Enoyl-CoA hydratase
HG718_RS01390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HG718_RS01405	COG1136	(ABC) transporter
HG718_RS01445	COG0069	glutamate synthase activity
HG718_RS01445	COG0070	glutamate synthase
HG718_RS01445	COG0067	glutamate synthase
HG718_RS01455	COG3220	belongs to the UPF0276 family
HG718_RS01475	COG3278	Belongs to the heme-copper respiratory oxidase family
HG718_RS01490	COG2010	Cytochrome c
HG718_RS01495	COG0348	domain, Protein
HG718_RS01505	COG2217	Heavy metal translocating P-type atpase
HG718_RS01540	COG0071	Belongs to the small heat shock protein (HSP20) family
HG718_RS01550	COG2358	TRAP transporter, solute receptor (TAXI family
HG718_RS01585	COG2353	YceI-like domain
HG718_RS01590	COG0438	transferase activity, transferring glycosyl groups
HG718_RS01600	COG1597	lipid kinase activity
HG718_RS01605	COG0069	glutamate synthase activity
HG718_RS01655	COG2226	methyltransferase
HG718_RS01680	COG1960	acyl-CoA dehydrogenase activity
HG718_RS01690	COG3046	protein related to deoxyribodipyrimidine photolyase
HG718_RS01700	COG2814	Major facilitator Superfamily
HG718_RS01720	COG3268	Saccharopine dehydrogenase
HG718_RS01730	COG0596	Alpha beta hydrolase
HG718_RS01735	COG0469	pyruvate kinase activity
HG718_RS01750	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HG718_RS01760	COG3750	Belongs to the UPF0335 family
HG718_RS01765	COG2204	response regulator
HG718_RS01780	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG718_RS01810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HG718_RS01815	COG0242	peptide deformylase activity
HG718_RS01830	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HG718_RS01835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HG718_RS01840	COG3706	GGDEF domain
HG718_RS01860	COG1846	Transcriptional regulator
HG718_RS01865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG718_RS01865	COG0730	response to heat
HG718_RS01885	COG0604	alcohol dehydrogenase
HG718_RS01885	COG3321	synthase
HG718_RS01885	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS01900	COG0254	rRNA binding
HG718_RS01905	COG1132	(ABC) transporter
HG718_RS01945	COG0483	inositol monophosphate 1-phosphatase activity
HG718_RS01950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HG718_RS01960	COG0352	thiamine-phosphate diphosphorylase activity
HG718_RS01965	COG3588	fructose-bisphosphate aldolase
HG718_RS01970	COG0126	phosphoglycerate kinase activity
HG718_RS02000	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HG718_RS02005	COG1692	metallophosphoesterase
HG718_RS02010	COG0217	transcriptional regulatory protein
HG718_RS02015	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HG718_RS02020	COG0632	four-way junction helicase activity
HG718_RS02025	COG2255	four-way junction helicase activity
HG718_RS02030	COG0824	Thioesterase
HG718_RS02040	COG0848	biopolymer transport protein
HG718_RS02050	COG0823	Involved in the tonB-independent uptake of proteins
HG718_RS02055	COG2885	chlorophyll binding
HG718_RS02065	COG0037	tRNA processing
HG718_RS02070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG718_RS02080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG718_RS02085	COG0351	phosphomethylpyrimidine kinase
HG718_RS02090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HG718_RS02105	COG0697	spore germination
HG718_RS02110	COG3119	arylsulfatase activity
HG718_RS02120	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HG718_RS02125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HG718_RS02130	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HG718_RS02145	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HG718_RS02165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG718_RS02180	COG0564	pseudouridine synthase activity
HG718_RS02235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG718_RS02250	COG2198	Histidine kinase
HG718_RS02250	COG0643	Histidine kinase
HG718_RS02270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HG718_RS02275	COG0745	RESPONSE REGULATOR receiver
HG718_RS02305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG718_RS02310	COG2204	response regulator
HG718_RS02315	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG718_RS02320	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG718_RS02325	COG1317	bacterial-type flagellum organization
HG718_RS02330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG718_RS02335	COG1766	The M ring may be actively involved in energy transduction
HG718_RS02345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HG718_RS02355	COG0482	sulfurtransferase activity
HG718_RS02375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HG718_RS02385	COG0789	Transcriptional regulator
HG718_RS02410	COG0564	pseudouridine synthase activity
HG718_RS02425	COG0183	Belongs to the thiolase family
HG718_RS02435	COG0596	Alpha beta hydrolase
HG718_RS02465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HG718_RS02475	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HG718_RS02480	COG2072	flavoprotein involved in K transport
HG718_RS02495	COG2224	Isocitrate lyase
HG718_RS02500	COG3800	Transcriptional regulator
HG718_RS02500	COG1396	sequence-specific DNA binding
HG718_RS02510	COG1960	acyl-CoA dehydrogenase activity
HG718_RS02525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG718_RS02565	COG1051	belongs to the nudix hydrolase family
HG718_RS02585	COG1741	Belongs to the pirin family
HG718_RS02620	COG0714	Associated with various cellular activities
HG718_RS02630	COG0494	nUDIX hydrolase
HG718_RS02645	COG0784	Response regulator, receiver
HG718_RS02645	COG2205	protein histidine kinase activity
HG718_RS02645	COG5002	protein histidine kinase activity
HG718_RS02655	COG0408	coproporphyrinogen oxidase activity
HG718_RS02660	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HG718_RS02665	COG0723	plastoquinol--plastocyanin reductase activity
HG718_RS02670	COG2857	Cytochrome c1
HG718_RS02670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG718_RS02675	COG2857	Cytochrome c1
HG718_RS02675	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HG718_RS02680	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HG718_RS02685	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HG718_RS02690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HG718_RS02700	COG0412	Dienelactone hydrolase
HG718_RS02715	COG0012	GTP binding
HG718_RS02720	COG0193	aminoacyl-tRNA hydrolase activity
HG718_RS02725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HG718_RS02735	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HG718_RS02755	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HG718_RS02785	COG0745	RESPONSE REGULATOR receiver
HG718_RS02790	COG1846	Transcriptional regulator
HG718_RS02800	COG0314	molybdopterin synthase activity
HG718_RS02805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HG718_RS02810	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG718_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS02855	COG0556	nucleotide-excision repair
HG718_RS02860	COG2132	Multicopper oxidase
HG718_RS02870	COG0840	transmembrane signaling receptor activity
HG718_RS02945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG718_RS02950	COG0783	Belongs to the Dps family
HG718_RS02960	COG0583	DNA-binding transcription factor activity
HG718_RS02965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG718_RS02970	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HG718_RS02980	COG0450	alkyl hydroperoxide reductase
HG718_RS02990	COG1522	sequence-specific DNA binding
HG718_RS02995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HG718_RS03000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HG718_RS03005	COG2852	Protein conserved in bacteria
HG718_RS03015	COG0505	Belongs to the CarA family
HG718_RS03025	COG0358	DNA primase activity
HG718_RS03030	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HG718_RS03045	COG3128	pkhd-type hydroxylase
HG718_RS03090	COG2968	Membrane
HG718_RS03125	COG1309	transcriptional regulator
HG718_RS03130	COG0488	(ABC) transporter
HG718_RS03135	COG1830	Aldolase
HG718_RS03145	COG2853	Lipoprotein
HG718_RS03150	COG2226	methyltransferase
HG718_RS03165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HG718_RS03180	COG3023	N-Acetylmuramoyl-L-alanine amidase
HG718_RS03195	COG2001	Belongs to the MraZ family
HG718_RS03200	COG0275	rRNA processing
HG718_RS03215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG718_RS03225	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG718_RS03230	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HG718_RS03240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HG718_RS03245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HG718_RS03250	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HG718_RS03255	COG1181	Belongs to the D-alanine--D-alanine ligase family
HG718_RS03265	COG0849	cell division
HG718_RS03270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HG718_RS03285	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG718_RS03290	COG0497	DNA recombination
HG718_RS03295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG718_RS03300	COG0006	proline dipeptidase activity
HG718_RS03300	COG0006	proline dipeptidase activity
HG718_RS03305	COG2264	protein methyltransferase activity
HG718_RS03310	COG0210	DNA helicase
HG718_RS03315	COG0038	chloride channel
HG718_RS03335	COG0277	FAD linked oxidase domain protein
HG718_RS03355	COG0114	fumarate hydratase activity
HG718_RS03405	COG0489	protein tyrosine kinase activity
HG718_RS03410	COG0330	HflC and HflK could
HG718_RS03430	COG3830	Belongs to the UPF0237 family
HG718_RS03430	COG0560	Phosphoserine phosphatase
HG718_RS03435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HG718_RS03440	COG0028	Belongs to the TPP enzyme family
HG718_RS03445	COG0440	acetolactate synthase activity
HG718_RS03450	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HG718_RS03475	COG2226	methyltransferase
HG718_RS03475	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HG718_RS03475	COG0596	Alpha beta hydrolase
HG718_RS03490	COG4122	O-methyltransferase activity
HG718_RS03505	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG718_RS03525	COG0768	penicillin binding
HG718_RS03530	COG0772	Belongs to the SEDS family
HG718_RS03550	COG3706	GGDEF domain
HG718_RS03560	COG2119	membrane
HG718_RS03575	COG2304	oxidoreductase activity
HG718_RS03580	COG4651	solute:proton antiporter activity
HG718_RS03580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HG718_RS03585	COG0589	response to stress
HG718_RS03590	COG1902	pentaerythritol trinitrate reductase activity
HG718_RS03590	COG0446	pyridine nucleotide-disulphide oxidoreductase
HG718_RS03615	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HG718_RS03620	COG2096	Adenosyltransferase
HG718_RS03630	COG1410	methionine synthase
HG718_RS03630	COG0646	methionine synthase
HG718_RS03635	COG5285	phytanoyl-CoA dioxygenase
HG718_RS03660	COG2226	methyltransferase
HG718_RS03665	COG0438	transferase activity, transferring glycosyl groups
HG718_RS03680	COG2267	carboxylic ester hydrolase activity
HG718_RS03690	COG0318	PFAM AMP-dependent synthetase and ligase
HG718_RS03695	COG2363	Small membrane protein
HG718_RS03710	COG3321	synthase
HG718_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS03710	COG0604	alcohol dehydrogenase
HG718_RS03720	COG3474	cytochrome
HG718_RS03725	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG718_RS03730	COG1127	ABC transporter
HG718_RS03735	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HG718_RS03735	COG3218	ABC-type transport auxiliary lipoprotein component
HG718_RS03760	COG1309	transcriptional regulator
HG718_RS03765	COG1024	Enoyl-CoA hydratase
HG718_RS03770	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HG718_RS03780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG718_RS03785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HG718_RS03790	COG2089	acid synthase
HG718_RS03800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG718_RS03805	COG1083	cytidylyl-transferase
HG718_RS03865	COG0587	DNA-directed DNA polymerase activity
HG718_RS03875	COG1959	2 iron, 2 sulfur cluster binding
HG718_RS03895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HG718_RS03900	COG1671	Belongs to the UPF0178 family
HG718_RS03905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG718_RS03915	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HG718_RS03940	COG5443	negative regulation of bacterial-type flagellum assembly
HG718_RS03955	COG0457	Tetratricopeptide repeat
HG718_RS03955	COG0859	PFAM glycosyl transferase family 9
HG718_RS03970	COG3951	Flagellar rod assembly protein muramidase FlgJ
HG718_RS03975	COG1706	bacterial-type flagellum-dependent cell motility
HG718_RS04000	COG4786	Flagellar basal body rod
HG718_RS04005	COG4786	Flagellar basal body rod
HG718_RS04045	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HG718_RS04050	COG0583	DNA-binding transcription factor activity
HG718_RS04055	COG1338	Plays a role in the flagellum-specific transport system
HG718_RS04070	COG1558	bacterial-type flagellum-dependent cell motility
HG718_RS04075	COG1677	Flagellar hook-basal body complex protein FliE
HG718_RS04080	COG1987	bacterial-type flagellum assembly
HG718_RS04085	COG1684	flagellar biosynthetic protein fliR
HG718_RS04090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HG718_RS04100	COG2323	membrane
HG718_RS04105	COG4638	Rieske (2fe-2S)
HG718_RS04115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HG718_RS04120	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HG718_RS04125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG718_RS04130	COG0538	isocitrate dehydrogenase activity
HG718_RS04145	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HG718_RS04150	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HG718_RS04155	COG0271	Belongs to the BolA IbaG family
HG718_RS04160	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG718_RS04165	COG0047	phosphoribosylformylglycinamidine synthase activity
HG718_RS04170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HG718_RS04175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HG718_RS04210	COG0406	alpha-ribazole phosphatase activity
HG718_RS04220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HG718_RS04230	COG0583	DNA-binding transcription factor activity
HG718_RS04235	COG2003	Belongs to the UPF0758 family
HG718_RS04240	COG0024	Methionine aminopeptidase
HG718_RS04245	COG1489	DNA binding
HG718_RS04250	COG1546	Belongs to the CinA family
HG718_RS04250	COG1058	Belongs to the CinA family
HG718_RS04280	COG1573	uracil-dna glycosylase
HG718_RS04305	COG2211	Major facilitator Superfamily
HG718_RS04310	COG2211	Major facilitator Superfamily
HG718_RS04315	COG1473	amidohydrolase
HG718_RS04335	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS04350	COG1024	Enoyl-CoA hydratase
HG718_RS04400	COG2847	Copper chaperone PCu(A)C
HG718_RS04405	COG2211	Major facilitator Superfamily
HG718_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS04470	COG1024	Enoyl-CoA hydratase
HG718_RS04480	COG4520	surface antigen
HG718_RS04495	COG0300	oxidoreductase activity
HG718_RS04530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG718_RS04560	COG1462	curli production assembly transport component CsgG
HG718_RS04595	COG0517	IMP dehydrogenase activity
HG718_RS04600	COG1752	Esterase of the alpha-beta hydrolase superfamily
HG718_RS04615	COG0302	gtp cyclohydrolase
HG718_RS04625	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
HG718_RS04630	COG2132	Multicopper oxidase
HG718_RS04645	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HG718_RS04650	COG0840	transmembrane signaling receptor activity
HG718_RS04655	COG0840	transmembrane signaling receptor activity
HG718_RS04665	COG0778	Nitroreductase
HG718_RS04670	COG0189	ligase activity
HG718_RS04670	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HG718_RS04680	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG718_RS04680	COG0596	Alpha beta hydrolase
HG718_RS04690	COG0534	Mate efflux family protein
HG718_RS04695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HG718_RS04700	COG2301	Belongs to the HpcH HpaI aldolase family
HG718_RS04720	COG2814	Major facilitator Superfamily
HG718_RS04750	COG1917	Cupin 2, conserved barrel domain protein
HG718_RS04755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HG718_RS04760	COG0456	acetyltransferase
HG718_RS04770	COG1960	acyl-CoA dehydrogenase activity
HG718_RS04800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HG718_RS04810	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HG718_RS04815	COG0277	FAD linked oxidase domain protein
HG718_RS04820	COG0235	Class ii aldolase
HG718_RS04825	COG1309	transcriptional regulator
HG718_RS04840	COG1556	Lactate utilization protein
HG718_RS04845	COG1139	Iron-sulfur cluster binding protein
HG718_RS04850	COG0247	lactate metabolic process
HG718_RS04875	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG718_RS04880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HG718_RS04890	COG1562	ergosterol biosynthetic process
HG718_RS04895	COG1562	ergosterol biosynthetic process
HG718_RS04900	COG1233	COG1233 Phytoene dehydrogenase and related
HG718_RS04905	COG1657	PFAM Prenyltransferase squalene oxidase
HG718_RS04910	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HG718_RS04915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HG718_RS04920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG718_RS04925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HG718_RS04935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG718_RS04955	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HG718_RS04985	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG718_RS05000	COG0250	Participates in transcription elongation, termination and antitermination
HG718_RS05010	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HG718_RS05015	COG0081	regulation of translation
HG718_RS05020	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HG718_RS05025	COG0222	ribosome binding
HG718_RS05030	COG0085	RNA polymerase activity
HG718_RS05035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HG718_RS05050	COG0049	tRNA binding
HG718_RS05055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HG718_RS05060	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HG718_RS05065	COG0051	transcription antitermination factor activity, RNA binding
HG718_RS05070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HG718_RS05075	COG0088	Forms part of the polypeptide exit tunnel
HG718_RS05080	COG0089	rRNA binding
HG718_RS05085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HG718_RS05090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HG718_RS05095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HG718_RS05100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HG718_RS05105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HG718_RS05110	COG0255	Belongs to the universal ribosomal protein uL29 family
HG718_RS05115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HG718_RS05120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HG718_RS05125	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HG718_RS05130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HG718_RS05135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HG718_RS05140	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HG718_RS05145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HG718_RS05150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HG718_RS05155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HG718_RS05165	COG0200	Binds to the 23S rRNA
HG718_RS05170	COG0201	protein transport
HG718_RS05175	COG0563	adenylate kinase activity
HG718_RS05180	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HG718_RS05185	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HG718_RS05190	COG0202	RNA polymerase activity
HG718_RS05195	COG0203	ribosomal protein L17
HG718_RS05200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG718_RS05205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HG718_RS05210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HG718_RS05215	COG0564	pseudouridine synthase activity
HG718_RS05220	COG0546	phosphoglycolate phosphatase activity
HG718_RS05230	COG0321	lipoyl(octanoyl) transferase activity
HG718_RS05235	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HG718_RS05240	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG718_RS05240	COG1648	precorrin-2 dehydrogenase activity
HG718_RS05245	COG0175	sulfate reduction
HG718_RS05255	COG2239	Acts as a magnesium transporter
HG718_RS05280	COG1278	Cold shock
HG718_RS05285	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HG718_RS05290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HG718_RS05310	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HG718_RS05315	COG1192	Involved in chromosome partitioning
HG718_RS05330	COG1686	Belongs to the peptidase S11 family
HG718_RS05340	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HG718_RS05365	COG0537	adenosine 5'-monophosphoramidase activity
HG718_RS05395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HG718_RS05400	COG1940	carbohydrate kinase activity
HG718_RS05415	COG0784	Response regulator, receiver
HG718_RS05425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HG718_RS05430	COG0477	Major facilitator Superfamily
HG718_RS05450	COG0557	exoribonuclease II activity
HG718_RS05455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HG718_RS05455	COG1754	DNA topoisomerase type I activity
HG718_RS05465	COG0758	DNA mediated transformation
HG718_RS05465	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG718_RS05470	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HG718_RS05475	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG718_RS05480	COG0540	Belongs to the ATCase OTCase family
HG718_RS05495	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HG718_RS05500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG718_RS05505	COG0154	amidase activity
HG718_RS05510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HG718_RS05520	COG0625	glutathione transferase activity
HG718_RS05535	COG1946	Acyl-CoA thioesterase
HG718_RS05550	COG1970	mechanosensitive ion channel activity
HG718_RS05560	COG2329	Antibiotic biosynthesis monooxygenase
HG718_RS05580	COG0811	peptide transport
HG718_RS05595	COG1620	l-lactate permease
HG718_RS05600	COG0733	neurotransmitter:sodium symporter activity
HG718_RS05610	COG0288	reversible hydration of carbon dioxide
HG718_RS05615	COG3781	membrane
HG718_RS05625	COG1686	Belongs to the peptidase S11 family
HG718_RS05635	COG0531	amino acid
HG718_RS05640	COG0741	lytic transglycosylase activity
HG718_RS05645	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HG718_RS05650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HG718_RS05655	COG1573	uracil-dna glycosylase
HG718_RS05665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HG718_RS05670	COG1758	RNA polymerase activity
HG718_RS05685	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HG718_RS05690	COG0736	holo-[acyl-carrier-protein] synthase activity
HG718_RS05695	COG0681	Belongs to the peptidase S26 family
HG718_RS05700	COG0571	ribonuclease III activity
HG718_RS05710	COG1381	Involved in DNA repair and RecF pathway recombination
HG718_RS05715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG718_RS05735	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
HG718_RS05740	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HG718_RS05745	COG0471	metal ion transport
HG718_RS05745	COG3273	potassium ion transport
HG718_RS05755	COG1360	Flagellar Motor Protein
HG718_RS05760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HG718_RS05780	COG2084	Dehydrogenase
HG718_RS05795	COG0113	porphobilinogen synthase activity
HG718_RS05800	COG2226	methyltransferase
HG718_RS05810	COG1024	Enoyl-CoA hydratase
HG718_RS05845	COG0584	glycerophosphoryl diester phosphodiesterase
HG718_RS05850	COG0156	8-amino-7-oxononanoate synthase activity
HG718_RS05860	COG4957	zinc ion binding
HG718_RS05870	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HG718_RS05875	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG718_RS05875	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HG718_RS05885	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG718_RS05885	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HG718_RS05890	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HG718_RS05895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG718_RS05900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HG718_RS05905	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HG718_RS05925	COG0416	fatty acid biosynthetic process
HG718_RS05930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG718_RS05935	COG0776	regulation of translation
HG718_RS05955	COG0438	transferase activity, transferring glycosyl groups
HG718_RS05960	COG1596	polysaccharide export
HG718_RS06010	COG1612	heme a metabolic process
HG718_RS06020	COG1832	CoA-binding protein
HG718_RS06025	COG1024	Enoyl-CoA hydratase
HG718_RS06030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HG718_RS06035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HG718_RS06065	COG0436	Aminotransferase
HG718_RS06080	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HG718_RS06080	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HG718_RS06115	COG0346	lactoylglutathione lyase activity
HG718_RS06120	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HG718_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS06140	COG0366	Alpha amylase catalytic
HG718_RS06145	COG0651	ATP synthesis coupled electron transport
HG718_RS06160	COG0651	ATP synthesis coupled electron transport
HG718_RS06165	COG1006	Multisubunit Na H antiporter MnhC subunit
HG718_RS06180	COG1320	monovalent cation:proton antiporter activity
HG718_RS06185	COG2212	antiporter activity
HG718_RS06190	COG1863	multisubunit Na H antiporter MnhE subunit
HG718_RS06195	COG1278	Cold shock
HG718_RS06215	COG1309	transcriptional regulator
HG718_RS06260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG718_RS06265	COG4149	molybdate abc transporter
HG718_RS06270	COG0725	ABC transporter, periplasmic molybdate-binding protein
HG718_RS06275	COG0626	cystathionine gamma-synthase activity
HG718_RS06280	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HG718_RS06285	COG4597	amino acid ABC transporter
HG718_RS06290	COG0765	amino acid transport
HG718_RS06295	COG1126	abc transporter atp-binding protein
HG718_RS06305	COG2897	thiosulfate sulfurtransferase activity
HG718_RS06310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HG718_RS06315	COG3806	Anti-sigma factor
HG718_RS06320	COG0300	oxidoreductase activity
HG718_RS06330	COG2211	Major facilitator Superfamily
HG718_RS06335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG718_RS06350	COG0415	Belongs to the DNA photolyase family
HG718_RS06355	COG4175	Glycine betaine
HG718_RS06360	COG4176	ABC-type proline glycine betaine transport system permease component
HG718_RS06390	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG718_RS06405	COG0525	valine-tRNA ligase activity
HG718_RS06415	COG0129	dihydroxy-acid dehydratase activity
HG718_RS06425	COG4067	protein conserved in archaea
HG718_RS06425	COG0189	ligase activity
HG718_RS06430	COG0189	ligase activity
HG718_RS06460	COG0316	Belongs to the HesB IscA family
HG718_RS06470	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HG718_RS06475	COG0018	arginyl-trna synthetase
HG718_RS06485	COG1472	Belongs to the glycosyl hydrolase 3 family
HG718_RS06495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HG718_RS06500	COG3842	ATPase activity
HG718_RS06505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG718_RS06510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HG718_RS06515	COG0805	protein transport
HG718_RS06520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HG718_RS06525	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HG718_RS06530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HG718_RS06545	COG1862	Preprotein translocase
HG718_RS06550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HG718_RS06575	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HG718_RS06590	COG0154	amidase activity
HG718_RS06605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HG718_RS06610	COG0629	single-stranded DNA binding
HG718_RS06625	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HG718_RS06630	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HG718_RS06645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HG718_RS06685	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HG718_RS06690	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HG718_RS06700	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HG718_RS06705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HG718_RS06710	COG1121	(ABC) transporter
HG718_RS06750	COG0625	glutathione transferase activity
HG718_RS06780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HG718_RS06785	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HG718_RS06805	COG0346	lactoylglutathione lyase activity
HG718_RS06820	COG0110	maltose O-acetyltransferase activity
HG718_RS06830	COG4166	transmembrane transport
HG718_RS06845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG718_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
HG718_RS06870	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS06890	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HG718_RS06895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HG718_RS06910	COG3706	GGDEF domain
HG718_RS06940	COG1024	Enoyl-CoA hydratase
HG718_RS06945	COG2353	YceI-like domain
HG718_RS06965	COG0183	Belongs to the thiolase family
HG718_RS06980	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HG718_RS06985	COG2832	Protein of unknown function (DUF454)
HG718_RS07010	COG2032	superoxide dismutase activity
HG718_RS07015	COG0084	hydrolase, TatD family'
HG718_RS07030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HG718_RS07035	COG1686	Belongs to the peptidase S11 family
HG718_RS07075	COG0523	cobalamin synthesis protein
HG718_RS07100	COG4251	negative regulation of phosphorylation
HG718_RS07135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG718_RS07140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG718_RS07150	COG0513	Belongs to the DEAD box helicase family
HG718_RS07165	COG1024	Enoyl-CoA hydratase
HG718_RS07170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HG718_RS07200	COG0668	transmembrane transport
HG718_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS07215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG718_RS07220	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS07230	COG2211	Major facilitator Superfamily
HG718_RS07235	COG3956	TIGRFAM MazG family protein
HG718_RS07240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HG718_RS07245	COG1923	regulation of RNA biosynthetic process
HG718_RS07255	COG0569	domain protein
HG718_RS07260	COG2204	response regulator
HG718_RS07265	COG5000	phosphorelay sensor kinase activity
HG718_RS07270	COG2204	response regulator
HG718_RS07280	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG718_RS07290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HG718_RS07295	COG1058	Belongs to the CinA family
HG718_RS07295	COG1546	Belongs to the CinA family
HG718_RS07300	COG2867	negative regulation of translational initiation
HG718_RS07305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HG718_RS07315	COG0861	Integral membrane protein TerC family
HG718_RS07325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG718_RS07330	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG718_RS07340	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG718_RS07340	COG0022	dehydrogenase e1 component
HG718_RS07345	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HG718_RS07370	COG0148	phosphopyruvate hydratase activity
HG718_RS07375	COG0625	glutathione transferase activity
HG718_RS07415	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HG718_RS07420	COG0602	queuosine metabolic process
HG718_RS07425	COG0720	synthase
HG718_RS07430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HG718_RS07435	COG2205	protein histidine kinase activity
HG718_RS07435	COG2202	Pas domain
HG718_RS07445	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HG718_RS07450	COG0504	CTP synthase activity
HG718_RS07455	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HG718_RS07470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HG718_RS07475	COG2861	carbohydrate metabolic process
HG718_RS07485	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HG718_RS07490	COG0134	indole-3-glycerol-phosphate synthase activity
HG718_RS07500	COG0315	cyclic pyranopterin monophosphate synthase activity
HG718_RS07505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HG718_RS07515	COG0658	competence protein
HG718_RS07515	COG2333	competence protein COMEC
HG718_RS07520	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG718_RS07525	COG0372	Belongs to the citrate synthase family
HG718_RS07530	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG718_RS07535	COG3494	Protein of unknown function (DUF1009)
HG718_RS07545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG718_RS07550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HG718_RS07560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HG718_RS07565	COG0750	zinc metalloprotease
HG718_RS07570	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HG718_RS07580	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HG718_RS07585	COG0233	cytoplasmic translational termination
HG718_RS07590	COG0528	UMP kinase activity
HG718_RS07595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HG718_RS07600	COG0052	Belongs to the universal ribosomal protein uS2 family
HG718_RS07625	COG0442	prolyl-tRNA aminoacylation
HG718_RS07670	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HG718_RS07680	COG1007	ATP synthesis coupled electron transport
HG718_RS07695	COG0713	ATP synthesis coupled electron transport
HG718_RS07705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG718_RS07710	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HG718_RS07730	COG0649	NAD binding
HG718_RS07735	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG718_RS07740	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG718_RS07745	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HG718_RS07760	COG2197	response regulator
HG718_RS07770	COG2831	hemolysin activation secretion protein
HG718_RS07795	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HG718_RS07800	COG0740	serine-type endopeptidase activity
HG718_RS07805	COG0544	peptidyl-prolyl cis-trans isomerase activity
HG718_RS07830	COG1247	-acetyltransferase
HG718_RS07835	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HG718_RS07835	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HG718_RS07850	COG0183	Belongs to the thiolase family
HG718_RS07870	COG0347	Belongs to the P(II) protein family
HG718_RS07875	COG0174	glutamine synthetase
HG718_RS07885	COG0154	amidase activity
HG718_RS07900	COG0187	DNA topoisomerase II activity
HG718_RS07905	COG0513	Belongs to the DEAD box helicase family
HG718_RS07920	COG1012	belongs to the aldehyde dehydrogenase family
HG718_RS07930	COG1024	Enoyl-CoA hydratase
HG718_RS07935	COG1024	Enoyl-CoA hydratase
HG718_RS07950	COG0316	Belongs to the HesB IscA family
HG718_RS07955	COG2151	metal-sulfur cluster biosynthetic enzyme
HG718_RS07960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HG718_RS07965	COG0719	Fe-S assembly protein
HG718_RS07970	COG0396	ATPase activity
HG718_RS07980	COG0719	Fe-S assembly protein
HG718_RS07985	COG1104	cysteine desulfurase activity
HG718_RS07990	COG1959	2 iron, 2 sulfur cluster binding
HG718_RS07995	COG2945	thiolester hydrolase activity
HG718_RS08000	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HG718_RS08005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HG718_RS08015	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HG718_RS08020	COG2833	Protein of unknown function (DUF455)
HG718_RS08025	COG0739	heme binding
HG718_RS08040	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG718_RS08045	COG0860	N-Acetylmuramoyl-L-alanine amidase
HG718_RS08050	COG1530	ribonuclease E activity
HG718_RS08050	COG1530	ribonuclease E activity
HG718_RS08055	COG0436	Aminotransferase
HG718_RS08075	COG2022	thiamine diphosphate biosynthetic process
HG718_RS08085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HG718_RS08090	COG0511	ligase activity, forming carbon-carbon bonds
HG718_RS08095	COG0439	Biotin carboxylase
HG718_RS08100	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HG718_RS08120	COG0745	RESPONSE REGULATOR receiver
HG718_RS08125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG718_RS08130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HG718_RS08135	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HG718_RS08140	COG0248	Ppx GppA phosphatase
HG718_RS08145	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HG718_RS08155	COG0628	permease
HG718_RS08160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HG718_RS08170	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HG718_RS08175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HG718_RS08185	COG0105	UTP biosynthetic process
HG718_RS08190	COG0488	(ABC) transporter
HG718_RS08200	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG718_RS08215	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HG718_RS08220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HG718_RS08230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HG718_RS08235	COG1454	alcohol dehydrogenase
HG718_RS08240	COG1063	alcohol dehydrogenase
HG718_RS08250	COG1561	YicC-like family, N-terminal region
HG718_RS08255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HG718_RS08260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HG718_RS08265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HG718_RS08275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HG718_RS08280	COG3811	Belongs to the UPF0386 family
HG718_RS08285	COG0360	Binds together with S18 to 16S ribosomal RNA
HG718_RS08290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HG718_RS08305	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HG718_RS08315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HG718_RS08320	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HG718_RS08335	COG1286	toxin biosynthetic process
HG718_RS08340	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HG718_RS08345	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS08350	COG1160	GTP binding
HG718_RS08365	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HG718_RS08390	COG4221	oxidoreductase activity
HG718_RS08395	COG3920	Histidine kinase
HG718_RS08420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG718_RS08420	COG0519	Catalyzes the synthesis of GMP from XMP
HG718_RS08425	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HG718_RS08425	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HG718_RS08460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG718_RS08465	COG3119	arylsulfatase activity
HG718_RS08480	COG1024	Enoyl-CoA hydratase
HG718_RS08485	COG0183	Belongs to the thiolase family
HG718_RS08515	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG718_RS08530	COG0688	phosphatidylethanolamine metabolic process
HG718_RS08535	COG5265	(ABC) transporter
HG718_RS08550	COG2962	Rard protein
HG718_RS08555	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HG718_RS08560	COG0215	cysteine-tRNA ligase activity
HG718_RS08565	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HG718_RS08575	COG0673	inositol 2-dehydrogenase activity
HG718_RS08580	COG2130	NADP-dependent
HG718_RS08585	COG2130	NADP-dependent
HG718_RS08595	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HG718_RS08605	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HG718_RS08620	COG0546	phosphoglycolate phosphatase activity
HG718_RS08635	COG2205	protein histidine kinase activity
HG718_RS08635	COG2202	Pas domain
HG718_RS08640	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HG718_RS08645	COG2267	carboxylic ester hydrolase activity
HG718_RS08650	COG1573	uracil-dna glycosylase
HG718_RS08655	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG718_RS08675	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HG718_RS08680	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS08685	COG0784	Response regulator, receiver
HG718_RS08685	COG5002	protein histidine kinase activity
HG718_RS08690	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08695	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HG718_RS08700	COG1024	Enoyl-CoA hydratase
HG718_RS08705	COG2202	Pas domain
HG718_RS08705	COG2205	protein histidine kinase activity
HG718_RS08710	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08715	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HG718_RS08745	COG0730	response to heat
HG718_RS08750	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HG718_RS08755	COG3932	Exopolysaccharide synthesis, ExoD
HG718_RS08770	COG4638	Rieske (2fe-2S)
HG718_RS08775	COG0521	Mo-molybdopterin cofactor biosynthetic process
HG718_RS08780	COG0303	'Molybdopterin
HG718_RS08785	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08795	COG1846	Transcriptional regulator
HG718_RS08815	COG0308	aminopeptidase N
HG718_RS08820	COG2202	Pas domain
HG718_RS08820	COG2205	protein histidine kinase activity
HG718_RS08835	COG1595	DNA-templated transcription, initiation
HG718_RS08845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG718_RS08860	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HG718_RS08865	COG0776	regulation of translation
HG718_RS08875	COG1704	LemA family
HG718_RS08885	COG0642	Histidine kinase
HG718_RS08890	COG0745	RESPONSE REGULATOR receiver
HG718_RS08900	COG3088	subunit of a heme lyase
HG718_RS08905	COG1138	Cytochrome C-type biogenesis protein
HG718_RS08910	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HG718_RS08920	COG4235	cytochrome complex assembly
HG718_RS08930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG718_RS08935	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG718_RS08955	COG1295	ribonuclease BN
HG718_RS08965	COG2205	protein histidine kinase activity
HG718_RS08970	COG0745	RESPONSE REGULATOR receiver
HG718_RS08985	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08990	COG1960	acyl-CoA dehydrogenase activity
HG718_RS08995	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS09030	COG2205	protein histidine kinase activity
HG718_RS09045	COG2983	Belongs to the UPF0260 family
HG718_RS09075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG718_RS09085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG718_RS09105	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HG718_RS09110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG718_RS09130	COG0668	transmembrane transport
HG718_RS09155	COG2205	protein histidine kinase activity
HG718_RS09155	COG2202	Pas domain
HG718_RS09170	COG2166	iron-sulfur cluster assembly
HG718_RS09245	COG2205	protein histidine kinase activity
HG718_RS09245	COG2202	Pas domain
HG718_RS09260	COG1024	Enoyl-CoA hydratase
HG718_RS09270	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HG718_RS09285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HG718_RS09325	COG0583	DNA-binding transcription factor activity
HG718_RS09350	COG0583	DNA-binding transcription factor activity
HG718_RS09355	COG1960	acyl-CoA dehydrogenase activity
HG718_RS09360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HG718_RS09370	COG1012	belongs to the aldehyde dehydrogenase family
HG718_RS09375	COG0028	Belongs to the TPP enzyme family
HG718_RS09385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HG718_RS09400	COG0746	molybdenum cofactor guanylyltransferase activity
HG718_RS09405	COG2072	flavoprotein involved in K transport
HG718_RS09420	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HG718_RS09425	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HG718_RS09430	COG1116	anion transmembrane transporter activity
HG718_RS09435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HG718_RS09440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG718_RS09470	COG0811	peptide transport
HG718_RS09475	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HG718_RS09480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HG718_RS09485	COG4558	Periplasmic binding protein
HG718_RS09490	COG3720	iron ion transport
HG718_RS09495	COG4771	TonB-dependent receptor
HG718_RS09520	COG0784	Response regulator, receiver
HG718_RS09560	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HG718_RS09580	COG1132	(ABC) transporter
HG718_RS09585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HG718_RS09590	COG1994	Peptidase M50
HG718_RS09590	COG0517	IMP dehydrogenase activity
HG718_RS09605	COG2205	protein histidine kinase activity
HG718_RS09605	COG2202	Pas domain
HG718_RS09615	COG1024	Enoyl-CoA hydratase
HG718_RS09620	COG1024	Enoyl-CoA hydratase
HG718_RS09630	COG1309	transcriptional regulator
HG718_RS09660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HG718_RS09670	COG0318	PFAM AMP-dependent synthetase and ligase
HG718_RS09675	COG0154	amidase activity
HG718_RS09680	COG0300	oxidoreductase activity
HG718_RS09685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HG718_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS09710	COG0484	heat shock protein binding
HG718_RS09715	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG718_RS09720	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HG718_RS09730	COG4106	trans-aconitate 2-methyltransferase activity
HG718_RS09735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HG718_RS09745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HG718_RS09750	COG1722	exodeoxyribonuclease VII activity
HG718_RS09755	COG0123	including yeast histone deacetylase and acetoin utilization protein
HG718_RS09765	COG1309	transcriptional regulator
HG718_RS09780	COG1960	acyl-CoA dehydrogenase activity
HG718_RS09785	COG0009	L-threonylcarbamoyladenylate synthase
HG718_RS09790	COG0277	FAD linked oxidase domain protein
HG718_RS09795	COG1253	flavin adenine dinucleotide binding
HG718_RS09805	COG2135	peptidase activity
HG718_RS09820	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS09850	COG0028	Belongs to the TPP enzyme family
HG718_RS09860	COG0318	PFAM AMP-dependent synthetase and ligase
HG718_RS09865	COG0604	alcohol dehydrogenase
HG718_RS09875	COG0438	transferase activity, transferring glycosyl groups
HG718_RS09885	COG0354	folic acid binding
HG718_RS09890	COG2818	Glycosylase
HG718_RS09900	COG0259	pyridoxamine-phosphate oxidase activity
HG718_RS09920	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HG718_RS09925	COG0693	protein deglycase activity
HG718_RS09945	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HG718_RS09950	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HG718_RS09960	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS09970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG718_RS09970	COG0574	Belongs to the PEP-utilizing enzyme family
HG718_RS09975	COG0751	glycine-tRNA ligase activity
HG718_RS09980	COG0752	glycyl-tRNA synthetase alpha subunit
HG718_RS09995	COG2264	protein methyltransferase activity
HG718_RS10005	COG0142	geranyltranstransferase activity
HG718_RS10015	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HG718_RS10035	COG1573	uracil-dna glycosylase
HG718_RS10040	COG0741	lytic transglycosylase activity
HG718_RS10060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HG718_RS10080	COG1194	a g-specific adenine glycosylase
HG718_RS10090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HG718_RS10095	COG1196	nuclear chromosome segregation
HG718_RS10115	COG0356	it plays a direct role in the translocation of protons across the membrane
HG718_RS10120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG718_RS10125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG718_RS10130	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HG718_RS10145	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG718_RS10150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HG718_RS10155	COG0509	glycine decarboxylation via glycine cleavage system
HG718_RS10160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HG718_RS10170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HG718_RS10175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HG718_RS10185	COG0678	peroxiredoxin activity
HG718_RS10195	COG1678	Uncharacterized ACR, COG1678
HG718_RS10200	COG5001	Diguanylate cyclase
HG718_RS10200	COG3300	MHYT domain
HG718_RS10205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HG718_RS10210	COG0612	Peptidase, M16
HG718_RS10220	COG3346	SURF1 family
HG718_RS10235	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HG718_RS10245	COG0109	protoheme IX farnesyltransferase activity
HG718_RS10250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HG718_RS10255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HG718_RS10255	COG1565	acr, cog1565
HG718_RS10265	COG0312	modulator of DNA gyrase
HG718_RS10275	COG0659	secondary active sulfate transmembrane transporter activity
HG718_RS10300	COG1309	transcriptional regulator
HG718_RS10325	COG0312	modulator of DNA gyrase
HG718_RS10330	COG0483	inositol monophosphate 1-phosphatase activity
HG718_RS10345	COG1519	Transferase
HG718_RS10350	COG1663	tetraacyldisaccharide 4'-kinase activity
HG718_RS10360	COG0739	heme binding
HG718_RS10370	COG1570	exodeoxyribonuclease VII activity
HG718_RS10395	COG2205	protein histidine kinase activity
HG718_RS10395	COG2202	Pas domain
HG718_RS10405	COG1960	acyl-CoA dehydrogenase activity
HG718_RS10410	COG0590	tRNA wobble adenosine to inosine editing
HG718_RS10425	COG1187	pseudouridine synthase activity
HG718_RS10430	COG0742	ribosomal rna small subunit methyltransferase
HG718_RS10435	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HG718_RS10440	COG0166	Belongs to the GPI family
HG718_RS10445	COG0612	Peptidase, M16
HG718_RS10450	COG0612	Peptidase, M16
HG718_RS10460	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HG718_RS10470	COG0196	riboflavin kinase activity
HG718_RS10475	COG0745	RESPONSE REGULATOR receiver
HG718_RS10495	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HG718_RS10500	COG0386	Belongs to the glutathione peroxidase family
HG718_RS10510	COG0840	transmembrane signaling receptor activity
HG718_RS10515	COG2885	chlorophyll binding
HG718_RS10520	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS10535	COG0205	6-phosphofructokinase activity
HG718_RS10560	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HG718_RS10560	COG0546	phosphoglycolate phosphatase activity
HG718_RS10575	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HG718_RS10580	COG0459	protein refolding
HG718_RS10585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HG718_RS10590	COG0124	histidyl-tRNA synthetase
HG718_RS10595	COG0124	histidyl-tRNA synthetase
HG718_RS10600	COG2205	protein histidine kinase activity
HG718_RS10630	COG1403	HNH endonuclease
HG718_RS10650	COG2267	carboxylic ester hydrolase activity
HG718_RS10655	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS10665	COG1178	ABC-type Fe3 transport system permease component
HG718_RS10670	COG1840	ABC-type Fe3 transport system, periplasmic component
HG718_RS10675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG718_RS10685	COG2116	formate transmembrane transporter activity
HG718_RS10690	COG1132	(ABC) transporter
HG718_RS10700	COG3842	ATPase activity
HG718_RS10710	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HG718_RS10715	COG1176	ABC-type spermidine putrescine transport system, permease component I
HG718_RS10720	COG1177	transmembrane transport
HG718_RS10740	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG718_RS10745	COG0514	ATP-dependent DNA helicase (RecQ)
HG718_RS10780	COG0330	HflC and HflK could
HG718_RS10785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG718_RS10790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HG718_RS10790	COG0574	Belongs to the PEP-utilizing enzyme family
HG718_RS10800	COG2267	carboxylic ester hydrolase activity
HG718_RS10805	COG2072	flavoprotein involved in K transport
HG718_RS10810	COG0418	dihydroorotase activity
HG718_RS10840	COG2207	Transcriptional regulator
HG718_RS10850	COG1294	oxidase, subunit
HG718_RS10855	COG1271	oxidase subunit
HG718_RS10890	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS10910	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HG718_RS10915	COG1530	ribonuclease E activity
HG718_RS10920	COG0424	maF-like protein
HG718_RS10925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HG718_RS10935	COG5328	Belongs to the UPF0262 family
HG718_RS10940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HG718_RS10950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HG718_RS10970	COG0596	Alpha beta hydrolase
HG718_RS10975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HG718_RS11000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HG718_RS11010	COG4989	oxidoreductase activity
HG718_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS11030	COG3321	synthase
HG718_RS11030	COG0604	alcohol dehydrogenase
HG718_RS11035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HG718_RS11045	COG1309	transcriptional regulator
HG718_RS11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HG718_RS11075	COG0616	signal peptide processing
HG718_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS11090	COG1960	acyl-CoA dehydrogenase activity
HG718_RS11115	COG0183	Belongs to the thiolase family
HG718_RS11125	COG0432	Pfam Uncharacterised protein family UPF0047
HG718_RS11140	COG2030	dehydratase
HG718_RS11170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HG718_RS11240	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
HG718_RS11255	COG1024	Enoyl-CoA hydratase
HG718_RS11255	COG1250	3-hydroxyacyl-CoA dehydrogenase
HG718_RS11260	COG0183	Belongs to the thiolase family
HG718_RS11265	COG1960	acyl-CoA dehydrogenase activity
HG718_RS11270	COG1960	acyl-CoA dehydrogenase activity
HG718_RS11275	COG0789	Transcriptional regulator
HG718_RS11290	COG0730	response to heat
HG718_RS11300	COG0785	Cytochrome C biogenesis protein
HG718_RS11315	COG1201	RNA secondary structure unwinding
HG718_RS11325	COG1793	dna ligase
HG718_RS11360	COG1199	ATP-dependent helicase activity
HG718_RS11370	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HG718_RS11390	COG0167	dihydroorotate dehydrogenase activity
HG718_RS11395	COG1393	Belongs to the ArsC family
HG718_RS11400	COG0534	Mate efflux family protein
HG718_RS11420	COG1024	Enoyl-CoA hydratase
HG718_RS11450	COG0463	Glycosyl transferase, family 2
HG718_RS11465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HG718_RS11475	COG1346	cytolysis
HG718_RS11485	COG0717	Belongs to the dCTP deaminase family
HG718_RS11495	COG2967	ApaG domain
HG718_RS11500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HG718_RS11540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HG718_RS11545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HG718_RS11550	COG0842	Transport permease protein
HG718_RS11560	COG0745	RESPONSE REGULATOR receiver
HG718_RS11570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HG718_RS11580	COG0573	inorganic phosphate transmembrane transporter activity
HG718_RS11590	COG5002	protein histidine kinase activity
HG718_RS11610	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HG718_RS11635	COG1741	Belongs to the pirin family
HG718_RS11650	COG1902	pentaerythritol trinitrate reductase activity
HG718_RS11660	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HG718_RS11675	COG4977	sequence-specific DNA binding
HG718_RS11720	COG0420	3'-5' exonuclease activity
HG718_RS11725	COG0419	ATPase involved in DNA repair
HG718_RS11735	COG5489	Protein of unknown function (DUF736)
HG718_RS11745	COG2948	multi-organism process
HG718_RS11760	COG3846	protein secretion by the type IV secretion system
HG718_RS11770	COG3451	type IV secretory pathway VirB4
HG718_RS11785	COG4962	Type ii secretion system protein e
HG718_RS11805	COG1205	dead DEAH box helicase
HG718_RS11805	COG1111	helicase
HG718_RS11905	COG1131	(ABC) transporter
HG718_RS11910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG718_RS11910	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HG718_RS11915	COG0405	Gamma-glutamyltransferase
HG718_RS11920	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HG718_RS11925	COG0745	RESPONSE REGULATOR receiver
HG718_RS11930	COG0642	Histidine kinase
HG718_RS11935	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HG718_RS11940	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG718_RS11940	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HG718_RS11945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG718_RS11960	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HG718_RS11965	COG2205	protein histidine kinase activity
HG718_RS11975	COG0633	Ferredoxin
HG718_RS11985	COG0802	atpase or kinase
HG718_RS11990	COG3178	'Phosphotransferase
HG718_RS11995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HG718_RS12005	COG1074	ATP-dependent DNA helicase activity
HG718_RS12020	COG0285	dihydrofolate synthase activity
HG718_RS12025	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HG718_RS12030	COG0159	tryptophan synthase activity
HG718_RS12035	COG0133	tryptophan synthase activity
HG718_RS12040	COG0135	phosphoribosylanthranilate isomerase activity
HG718_RS12045	COG0284	orotidine-5'-phosphate decarboxylase activity
HG718_RS12060	COG2175	clavaminate synthase activity
HG718_RS12065	COG2423	ornithine cyclodeaminase activity
HG718_RS12075	COG0776	regulation of translation
HG718_RS12080	COG0539	negative regulation of cytoplasmic translation
HG718_RS12085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HG718_RS12090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HG718_RS12105	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HG718_RS12105	COG1648	precorrin-2 dehydrogenase activity
HG718_RS12110	COG0243	molybdopterin cofactor binding
HG718_RS12120	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HG718_RS12125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG718_RS12125	COG1116	anion transmembrane transporter activity
HG718_RS12135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG718_RS12140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HG718_RS12140	COG1116	anion transmembrane transporter activity
HG718_RS12155	COG1305	Transglutaminase-like
HG718_RS12165	COG2308	Evidence 4 Homologs of previously reported genes of
HG718_RS12175	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS12195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG718_RS12205	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS12230	COG0071	Belongs to the small heat shock protein (HSP20) family
HG718_RS12240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HG718_RS12245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HG718_RS12250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HG718_RS12255	COG1137	ATPase activity
HG718_RS12270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HG718_RS12270	COG0517	IMP dehydrogenase activity
HG718_RS12290	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HG718_RS12305	COG1968	undecaprenyl-diphosphatase activity
HG718_RS12340	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HG718_RS12345	COG4774	siderophore transport
HG718_RS12370	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HG718_RS12375	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HG718_RS12380	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HG718_RS12385	COG0072	phenylalanine-tRNA ligase activity
HG718_RS12385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HG718_RS12390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HG718_RS12395	COG0481	GTPase activity
HG718_RS12460	COG4964	Belongs to the GSP D family
HG718_RS12500	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HG718_RS12510	COG0791	NLP P60 protein
HG718_RS12515	COG4172	Belongs to the ABC transporter superfamily
HG718_RS12520	COG4239	(ABC) transporter, permease
HG718_RS12525	COG4174	ABC transporter (Permease)
HG718_RS12530	COG4166	transmembrane transport
HG718_RS12535	COG4166	transmembrane transport
HG718_RS12545	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HG718_RS12575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HG718_RS12585	COG1115	amino acid carrier protein
HG718_RS12595	COG0242	peptide deformylase activity
HG718_RS12600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG718_RS12605	COG0101	tRNA pseudouridine synthase activity
HG718_RS12610	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HG718_RS12620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HG718_RS12625	COG2171	N-acyltransferase activity
HG718_RS12645	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HG718_RS12650	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HG718_RS12655	COG0706	membrane insertase activity
HG718_RS12665	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HG718_RS12680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG718_RS12690	COG4106	trans-aconitate 2-methyltransferase activity
HG718_RS12695	COG3387	PFAM Glycoside hydrolase 15-related
HG718_RS12700	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HG718_RS12710	COG0405	Gamma-glutamyltransferase
HG718_RS12715	COG3191	aminopeptidase activity
HG718_RS12750	COG0235	Class ii aldolase
HG718_RS12790	COG0433	COG0433 Predicted ATPase
HG718_RS12800	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HG718_RS12810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HG718_RS12815	COG0156	8-amino-7-oxononanoate synthase activity
HG718_RS12860	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HG718_RS12860	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HG718_RS12880	COG1131	(ABC) transporter
HG718_RS12900	COG1999	signal sequence binding
HG718_RS12915	COG0667	Aldo Keto reductase
HG718_RS12920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HG718_RS12935	COG0740	serine-type endopeptidase activity
HG718_RS12940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HG718_RS12955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HG718_RS12965	COG0268	Binds directly to 16S ribosomal RNA
HG718_RS12975	COG1024	Enoyl-CoA hydratase
HG718_RS12980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HG718_RS12990	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HG718_RS13000	COG0756	dUTP diphosphatase activity
HG718_RS13025	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HG718_RS13045	COG1592	Rubrerythrin
HG718_RS13055	COG1051	belongs to the nudix hydrolase family
HG718_RS13065	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HG718_RS13075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HG718_RS13100	COG1185	polyribonucleotide nucleotidyltransferase activity
HG718_RS13105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HG718_RS13110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HG718_RS13115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HG718_RS13120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HG718_RS13130	COG0195	Participates in both transcription termination and antitermination
HG718_RS13130	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HG718_RS13135	COG0779	Required for maturation of 30S ribosomal subunits
HG718_RS13155	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HG718_RS13160	COG1396	sequence-specific DNA binding
HG718_RS13165	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HG718_RS13170	COG1253	flavin adenine dinucleotide binding
HG718_RS13175	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HG718_RS13180	COG1702	phosphate starvation-inducible protein PhoH
HG718_RS13185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG718_RS13200	COG0456	acetyltransferase
HG718_RS13205	COG1214	PFAM Peptidase M22, glycoprotease
HG718_RS13210	COG0778	Nitroreductase
HG718_RS13235	COG0180	Tryptophanyl-tRNA synthetase
HG718_RS13245	COG0728	peptidoglycan biosynthetic process
HG718_RS13260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HG718_RS13270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HG718_RS13275	COG0281	malic enzyme
HG718_RS13275	COG0280	phosphate acetyltransferase
HG718_RS13290	COG0606	chelatase, subunit chli
HG718_RS13310	COG0792	nuclease activity
HG718_RS13315	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HG718_RS13325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HG718_RS13330	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HG718_RS13335	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HG718_RS13340	COG1420	regulation of RNA biosynthetic process
HG718_RS13345	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HG718_RS13365	COG0443	Heat shock 70 kDa protein
HG718_RS13370	COG0484	heat shock protein binding
HG718_RS13375	COG2205	protein histidine kinase activity
HG718_RS13375	COG2202	Pas domain
HG718_RS13380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HG718_RS13385	COG0588	phosphoglycerate mutase activity
HG718_RS13395	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HG718_RS13410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HG718_RS13420	COG0140	phosphoribosyl-ATP diphosphatase activity
HG718_RS13430	COG0107	imidazoleglycerol-phosphate synthase activity
HG718_RS13440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HG718_RS13445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HG718_RS13450	COG0131	Imidazoleglycerol-phosphate dehydratase
HG718_RS13460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HG718_RS13465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HG718_RS13490	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HG718_RS13500	COG0237	dephospho-CoA kinase activity
HG718_RS13505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HG718_RS13510	COG0424	maF-like protein
HG718_RS13515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HG718_RS13520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HG718_RS13535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HG718_RS13560	COG1331	Highly conserved protein containing a thioredoxin domain
HG718_RS13570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HG718_RS13575	COG0445	tRNA wobble uridine modification
HG718_RS13605	COG0495	leucyl-tRNA aminoacylation
HG718_RS13615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HG718_RS13620	COG0352	thiamine-phosphate diphosphorylase activity
HG718_RS13625	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HG718_RS13640	COG0745	RESPONSE REGULATOR receiver
HG718_RS13670	COG0708	Exodeoxyribonuclease III
HG718_RS13685	COG1674	ftsk spoiiie
HG718_RS13700	COG0004	ammonium transporteR
HG718_RS13705	COG0004	ammonium transporteR
HG718_RS13710	COG0347	Belongs to the P(II) protein family
HG718_RS13725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HG718_RS13730	COG0537	adenosine 5'-monophosphoramidase activity
HG718_RS13740	COG2835	tetraacyldisaccharide 4'-kinase activity
HG718_RS13750	COG3118	belongs to the thioredoxin family
HG718_RS13780	COG1733	regulation of RNA biosynthetic process
HG718_RS13785	COG1063	alcohol dehydrogenase
HG718_RS13810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HG718_RS13845	COG0625	glutathione transferase activity
HG718_RS13855	COG3264	Mechanosensitive ion channel
HG718_RS13855	COG1196	nuclear chromosome segregation
HG718_RS13865	COG0625	glutathione transferase activity
HG718_RS13870	COG0583	DNA-binding transcription factor activity
HG718_RS13880	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS13910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HG718_RS13930	COG0640	Transcriptional regulator
HG718_RS13935	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HG718_RS13960	COG0463	Glycosyl transferase, family 2
HG718_RS13970	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HG718_RS14000	COG0393	Putative heavy-metal-binding
HG718_RS14005	COG0138	bifunctional purine biosynthesis protein purh
HG718_RS14030	COG0501	Belongs to the peptidase M48B family
HG718_RS14035	COG5508	conserved small protein
HG718_RS14045	COG0300	oxidoreductase activity
HG718_RS14055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HG718_RS14060	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HG718_RS14070	COG0454	-acetyltransferase
HG718_RS14105	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HG718_RS14120	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HG718_RS14125	COG0181	hydroxymethylbilane synthase activity
HG718_RS14145	COG2267	carboxylic ester hydrolase activity
HG718_RS14200	COG1024	Enoyl-CoA hydratase
HG718_RS14210	COG1309	transcriptional regulator
HG718_RS14215	COG1024	Enoyl-CoA hydratase
HG718_RS14240	COG2217	Heavy metal translocating P-type atpase
HG718_RS14250	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG718_RS14255	COG1960	acyl-CoA dehydrogenase activity
HG718_RS14270	COG1309	transcriptional regulator
HG718_RS14275	COG2169	Transcriptional regulator
HG718_RS14275	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HG718_RS14300	COG1396	sequence-specific DNA binding
HG718_RS14345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HG718_RS14375	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HG718_RS14380	COG0137	argininosuccinate synthase activity
HG718_RS14390	COG0583	DNA-binding transcription factor activity
HG718_RS14405	COG1309	transcriptional regulator
HG718_RS14420	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HG718_RS14430	COG1595	DNA-templated transcription, initiation
HG718_RS14450	COG0604	alcohol dehydrogenase
HG718_RS14450	COG3321	synthase
HG718_RS14450	COG1028	Short-chain dehydrogenase reductase Sdr
HG718_RS14460	COG0697	spore germination
HG718_RS14465	COG0697	spore germination
HG718_RS14490	COG2226	methyltransferase
HG718_RS14495	COG2154	pterin-4-alpha-carbinolamine dehydratase
HG718_RS14510	COG0667	Aldo Keto reductase
HG718_RS14520	COG1136	(ABC) transporter
HG718_RS14535	COG0670	Belongs to the BI1 family
HG718_RS14540	COG0840	transmembrane signaling receptor activity
HG718_RS14545	COG0475	glutathione-regulated potassium exporter activity
HG718_RS14555	COG1131	(ABC) transporter
HG718_RS14580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HG718_RS14585	COG1024	Enoyl-CoA hydratase
HG718_RS14590	COG4133	protoheme IX ABC transporter activity
HG718_RS14595	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG718_RS14600	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HG718_RS14610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HG718_RS14635	COG2827	Endonuclease containing a URI domain
HG718_RS14640	COG2917	probably involved in intracellular septation
HG718_RS14645	COG0552	protein localization to endoplasmic reticulum
HG718_RS14650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HG718_RS14655	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HG718_RS14690	COG0228	four-way junction DNA binding
HG718_RS14695	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HG718_RS14700	COG0336	Belongs to the RNA methyltransferase TrmD family
HG718_RS14705	COG0335	large ribosomal subunit rRNA binding
HG718_RS14710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HG718_RS14715	COG0066	3-isopropylmalate dehydratase activity
HG718_RS14730	COG0473	3-isopropylmalate dehydrogenase activity
HG718_RS14750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HG718_RS14765	COG0004	ammonium transporteR
HG718_RS14770	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HG718_RS14775	COG2301	Belongs to the HpcH HpaI aldolase family
HG718_RS14780	COG2030	dehydratase
HG718_RS14795	COG2009	succinate dehydrogenase
HG718_RS14805	COG1053	succinate dehydrogenase
HG718_RS14840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HG718_RS14845	COG0798	PFAM Bile acid sodium symporter
HG718_RS14860	COG1024	Enoyl-CoA hydratase
HG718_RS14865	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HG718_RS14875	COG0039	L-malate dehydrogenase activity
HG718_RS14885	COG0045	succinate-CoA ligase (ADP-forming) activity
HG718_RS14890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HG718_RS14900	COG0508	dehydrogenase complex catalyzes the overall conversion of
HG718_RS14910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HG718_RS14915	COG4974	Belongs to the 'phage' integrase family
HG718_RS14930	COG3300	MHYT domain
HG718_RS14930	COG5001	Diguanylate cyclase
HG718_RS14935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HG718_RS14940	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HG718_RS14945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HG718_RS14950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HG718_RS14955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HG718_RS14965	COG0494	nUDIX hydrolase
HG718_RS14975	COG0793	Belongs to the peptidase S41A family
HG718_RS14985	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HG718_RS14990	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HG718_RS14995	COG0799	negative regulation of ribosome biogenesis
HG718_RS15000	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HG718_RS15005	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HG718_RS15010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HG718_RS15015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HG718_RS15025	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HG718_RS15035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HG718_RS15040	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HG718_RS15070	COG4453	Protein conserved in bacteria
HG718_RS15085	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HG718_RS15100	COG2175	clavaminate synthase activity
HG718_RS15105	COG1309	transcriptional regulator
HG718_RS15130	COG0427	acetyl-CoA hydrolase
HG718_RS15135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HG718_RS15160	COG2146	nitrite reductase [NAD(P)H] activity
HG718_RS15160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HG718_RS15165	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HG718_RS15185	COG1088	dTDP-glucose 4,6-dehydratase activity
HG718_RS15205	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HG718_RS15210	COG1960	acyl-CoA dehydrogenase activity
HG718_RS15215	COG1960	acyl-CoA dehydrogenase activity
HG718_RS15250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HG718_RS15265	COG2409	Drug exporters of the RND superfamily
HG718_RS15270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HG718_RS15280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HG718_RS15295	COG0183	Belongs to the thiolase family
HG718_RS15300	COG3963	phosphatidate phosphatase activity
HG718_RS15305	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HG718_RS15355	COG1024	Enoyl-CoA hydratase
HG718_RS15365	COG0625	glutathione transferase activity
HG718_RS15375	COG1051	belongs to the nudix hydrolase family
HG718_RS15380	COG2130	NADP-dependent
HG718_RS15385	COG1960	acyl-CoA dehydrogenase activity
HG718_RS15390	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HG718_RS15430	COG2133	pyrroloquinoline quinone binding
HG718_RS15435	COG5310	Homospermidine synthase
HG718_RS15445	COG1234	tRNA 3'-trailer cleavage
HG718_RS15450	COG0583	DNA-binding transcription factor activity
HG718_RS15455	COG0473	3-isopropylmalate dehydrogenase activity
HG718_RS15465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HG718_RS15490	COG0519	Catalyzes the synthesis of GMP from XMP
HG718_RS15490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HG718_RS15550	COG0367	asparagine synthase