locus-tag	class	description
JHW33_RS00020	COG3279	Response regulator of the LytR AlgR family
JHW33_RS00025	COG3275	phosphorelay sensor kinase activity
JHW33_RS00035	COG0436	Aminotransferase
JHW33_RS00040	COG3038	cytochrome b561
JHW33_RS00045	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
JHW33_RS00055	COG1462	curli production assembly transport component CsgG
JHW33_RS00090	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
JHW33_RS00095	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
JHW33_RS00100	COG3383	formate dehydrogenase (NAD+) activity
JHW33_RS00105	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHW33_RS00110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
JHW33_RS00120	COG3260	NADH ubiquinone oxidoreductase 20
JHW33_RS00125	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS00130	COG3261	NADH dehydrogenase
JHW33_RS00130	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
JHW33_RS00135	COG0650	Formate hydrogenlyase subunit 4
JHW33_RS00140	COG0651	ATP synthesis coupled electron transport
JHW33_RS00145	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHW33_RS00155	COG0375	protein maturation
JHW33_RS00160	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
JHW33_RS00165	COG0298	carbon dioxide binding
JHW33_RS00170	COG0409	Hydrogenase expression formation protein
JHW33_RS00175	COG0309	Hydrogenase expression formation protein (HypE)
JHW33_RS00200	COG0583	DNA-binding transcription factor activity
JHW33_RS00210	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS00210	COG4641	Protein conserved in bacteria
JHW33_RS00220	COG0625	glutathione transferase activity
JHW33_RS00225	COG1609	Transcriptional regulator
JHW33_RS00230	COG0673	inositol 2-dehydrogenase activity
JHW33_RS00245	COG2211	Major facilitator Superfamily
JHW33_RS00255	COG1464	Belongs to the NlpA lipoprotein family
JHW33_RS00285	COG2003	Belongs to the UPF0758 family
JHW33_RS00340	COG1309	transcriptional regulator
JHW33_RS00345	COG0604	alcohol dehydrogenase
JHW33_RS00375	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS00395	COG0604	alcohol dehydrogenase
JHW33_RS00435	COG3121	Chaperone
JHW33_RS00445	COG3188	usher protein
JHW33_RS00460	COG0582	viral genome integration into host DNA
JHW33_RS00470	COG2116	formate transmembrane transporter activity
JHW33_RS00480	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHW33_RS00485	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHW33_RS00490	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
JHW33_RS00495	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
JHW33_RS00500	COG1138	Cytochrome C-type biogenesis protein
JHW33_RS00505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JHW33_RS00510	COG3088	subunit of a heme lyase
JHW33_RS00510	COG4235	cytochrome complex assembly
JHW33_RS00515	COG4235	cytochrome complex assembly
JHW33_RS00515	COG3088	subunit of a heme lyase
JHW33_RS00525	COG3385	transposase activity
JHW33_RS00530	COG2067	long-chain fatty acid transport protein
JHW33_RS00535	COG3691	Protein conserved in bacteria
JHW33_RS00540	COG0183	Belongs to the thiolase family
JHW33_RS00545	COG1024	Enoyl-CoA hydratase
JHW33_RS00545	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW33_RS00550	COG2062	phosphohistidine phosphatase, SixA
JHW33_RS00560	COG2890	protein-(glutamine-N5) methyltransferase activity
JHW33_RS00565	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JHW33_RS00575	COG0730	response to heat
JHW33_RS00580	COG3101	peptidyl-lysine hydroxylation
JHW33_RS00590	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
JHW33_RS00590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW33_RS00595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW33_RS00610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JHW33_RS00630	COG0697	spore germination
JHW33_RS00635	COG2207	Transcriptional regulator
JHW33_RS00640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW33_RS00645	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHW33_RS00655	COG0586	Pfam SNARE associated Golgi protein
JHW33_RS00660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JHW33_RS00665	COG0285	dihydrofolate synthase activity
JHW33_RS00670	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
JHW33_RS00675	COG1286	toxin biosynthetic process
JHW33_RS00680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
JHW33_RS00685	COG0163	prenyltransferase activity
JHW33_RS00690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS00695	COG4215	(ABC) transporter
JHW33_RS00705	COG4598	ABC transporter
JHW33_RS00710	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHW33_RS00715	COG0747	negative chemotaxis
JHW33_RS00720	COG1090	epimerase
JHW33_RS00725	COG0625	glutathione transferase activity
JHW33_RS00730	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JHW33_RS00735	COG1609	Transcriptional regulator
JHW33_RS00740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS00750	COG3037	sugar-specific permease SgaT UlaA
JHW33_RS00755	COG3959	Transketolase, thiamine diphosphate binding domain
JHW33_RS00760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHW33_RS00765	COG0857	belongs to the CobB CobQ family
JHW33_RS00765	COG0280	phosphate acetyltransferase
JHW33_RS00770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JHW33_RS00780	COG3092	negative regulation of chromosome organization
JHW33_RS00785	COG3013	Belongs to the UPF0304 family
JHW33_RS00790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW33_RS00795	COG0471	metal ion transport
JHW33_RS00795	COG0490	domain, Protein
JHW33_RS00800	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHW33_RS00805	COG0436	Aminotransferase
JHW33_RS00810	COG0583	DNA-binding transcription factor activity
JHW33_RS00815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS00825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS00825	COG0649	NAD binding
JHW33_RS00835	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
JHW33_RS00840	COG1034	ATP synthesis coupled electron transport
JHW33_RS00845	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
JHW33_RS00850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS00855	COG0839	Belongs to the complex I subunit 6 family
JHW33_RS00860	COG0713	ATP synthesis coupled electron transport
JHW33_RS00865	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
JHW33_RS00870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS00875	COG1007	ATP synthesis coupled electron transport
JHW33_RS00885	COG4575	ribosome binding
JHW33_RS00890	COG1169	isochorismate synthase
JHW33_RS00895	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
JHW33_RS00900	COG0596	Alpha beta hydrolase
JHW33_RS00905	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
JHW33_RS00910	COG1441	menaquinone biosynthetic process
JHW33_RS00935	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW33_RS00950	COG3468	outer membrane autotransporter barrel domain protein
JHW33_RS00955	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW33_RS00965	COG0784	Response regulator, receiver
JHW33_RS00965	COG2205	protein histidine kinase activity
JHW33_RS00970	COG2197	response regulator
JHW33_RS00975	COG2198	Histidine kinase
JHW33_RS00975	COG0642	Histidine kinase
JHW33_RS00990	COG1132	(ABC) transporter
JHW33_RS01010	COG2207	Transcriptional regulator
JHW33_RS01015	COG0768	penicillin binding
JHW33_RS01025	COG0435	Glutathione S-transferase
JHW33_RS01035	COG3082	Protein of unknown function (DUF1414)
JHW33_RS01040	COG3081	Nucleoid-associated protein
JHW33_RS01045	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JHW33_RS01050	COG1061	Type III restriction enzyme res subunit
JHW33_RS01055	COG1187	pseudouridine synthase activity
JHW33_RS01060	COG2814	Major facilitator Superfamily
JHW33_RS01070	COG1609	Transcriptional regulator
JHW33_RS01075	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS01105	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS01110	COG4239	(ABC) transporter, permease
JHW33_RS01115	COG4174	ABC transporter (Permease)
JHW33_RS01120	COG4166	transmembrane transport
JHW33_RS01125	COG2200	EAL domain
JHW33_RS01130	COG0791	NLP P60 protein
JHW33_RS01135	COG0671	phosphoesterase, PA-phosphatase related
JHW33_RS01140	COG0523	cobalamin synthesis protein
JHW33_RS01150	COG2186	Transcriptional regulator
JHW33_RS01155	COG0246	Mannitol dehydrogenase
JHW33_RS01160	COG3385	transposase activity
JHW33_RS01165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHW33_RS01185	COG1105	Belongs to the carbohydrate kinase PfkB family
JHW33_RS01190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS01190	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
JHW33_RS01190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS01195	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JHW33_RS01200	COG2855	membrane
JHW33_RS01205	COG0583	DNA-binding transcription factor activity
JHW33_RS01210	COG0833	amino acid
JHW33_RS01215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW33_RS01220	COG1120	ATPase activity
JHW33_RS01225	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JHW33_RS01240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHW33_RS01245	COG2824	Alkylphosphonate utilization operon protein PhnA
JHW33_RS01260	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
JHW33_RS01275	COG1126	abc transporter atp-binding protein
JHW33_RS01280	COG0765	amino acid transport
JHW33_RS01285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS01290	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
JHW33_RS01310	COG0783	Belongs to the Dps family
JHW33_RS01325	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
JHW33_RS01335	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
JHW33_RS01340	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JHW33_RS01345	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
JHW33_RS01375	COG0583	DNA-binding transcription factor activity
JHW33_RS01380	COG0066	3-isopropylmalate dehydratase activity
JHW33_RS01385	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHW33_RS01395	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
JHW33_RS01405	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS01410	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
JHW33_RS01415	COG2153	protein acetylation
JHW33_RS01435	COG5654	RES domain protein
JHW33_RS01440	COG5642	Protein of unknown function (DUF2384)
JHW33_RS01450	COG0488	(ABC) transporter
JHW33_RS01455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHW33_RS01460	COG0303	'Molybdopterin
JHW33_RS01465	COG1349	DNA-binding transcription factor activity
JHW33_RS01485	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS01490	COG0747	negative chemotaxis
JHW33_RS01495	COG0601	transmembrane transport
JHW33_RS01500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS01515	COG0583	DNA-binding transcription factor activity
JHW33_RS01520	COG0477	Major facilitator Superfamily
JHW33_RS01525	COG0302	gtp cyclohydrolase
JHW33_RS01530	COG2311	Membrane
JHW33_RS01535	COG1609	Transcriptional regulator
JHW33_RS01555	COG2949	membrane
JHW33_RS01560	COG0281	malic enzyme
JHW33_RS01565	COG0295	cytidine deaminase activity
JHW33_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS01575	COG4160	amino acid transport
JHW33_RS01580	COG4215	(ABC) transporter
JHW33_RS01585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS01590	COG1126	abc transporter atp-binding protein
JHW33_RS01600	COG0393	Putative heavy-metal-binding
JHW33_RS01605	COG3023	N-Acetylmuramoyl-L-alanine amidase
JHW33_RS01610	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW33_RS01615	COG0702	epimerase
JHW33_RS01620	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
JHW33_RS01625	COG0028	Belongs to the TPP enzyme family
JHW33_RS01630	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW33_RS01635	COG1151	hydroxylamine reductase activity
JHW33_RS01640	COG2431	L-lysine efflux transmembrane transporter activity
JHW33_RS01645	COG3593	DNA synthesis involved in DNA repair
JHW33_RS01650	COG2990	Protein conserved in bacteria
JHW33_RS01655	COG1278	Cold shock
JHW33_RS01660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
JHW33_RS01665	COG0542	response to heat
JHW33_RS01670	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JHW33_RS01675	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
JHW33_RS01680	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
JHW33_RS01685	COG4988	ABC transporter
JHW33_RS01690	COG0492	ferredoxin-NADP+ reductase activity
JHW33_RS01700	COG3107	peptidoglycan biosynthetic process
JHW33_RS01700	COG1674	ftsk spoiiie
JHW33_RS01705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
JHW33_RS01710	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JHW33_RS01715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JHW33_RS01725	COG0243	molybdopterin cofactor binding
JHW33_RS01730	COG0437	4 iron, 4 sulfur cluster binding
JHW33_RS01735	COG3302	dmso reductase anchor subunit
JHW33_RS01740	COG3381	protein complex oligomerization
JHW33_RS01750	COG2814	Major facilitator Superfamily
JHW33_RS01755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHW33_RS01760	COG1882	Formate acetyltransferase
JHW33_RS01765	COG2116	formate transmembrane transporter activity
JHW33_RS01770	COG1944	ATP diphosphatase activity
JHW33_RS01785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHW33_RS01790	COG0539	negative regulation of cytoplasmic translation
JHW33_RS01795	COG0776	regulation of translation
JHW33_RS01800	COG0658	competence protein
JHW33_RS01800	COG2333	competence protein COMEC
JHW33_RS01810	COG1663	tetraacyldisaccharide 4'-kinase activity
JHW33_RS01820	COG1278	Cold shock
JHW33_RS01825	COG3214	Protein conserved in bacteria
JHW33_RS01830	COG2835	tetraacyldisaccharide 4'-kinase activity
JHW33_RS01835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
JHW33_RS01840	COG3173	Aminoglycoside phosphotransferase
JHW33_RS01845	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JHW33_RS01850	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW33_RS01855	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
JHW33_RS01865	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHW33_RS01870	COG2989	Protein conserved in bacteria
JHW33_RS01875	COG3108	Peptidase M15
JHW33_RS01880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHW33_RS01885	COG1448	Aminotransferase
JHW33_RS01895	COG0017	Asparaginyl-tRNA synthetase
JHW33_RS01900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JHW33_RS01905	COG0308	aminopeptidase N
JHW33_RS01910	COG1116	anion transmembrane transporter activity
JHW33_RS01915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW33_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS01925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW33_RS01930	COG0431	NADPH-dependent FMN reductase
JHW33_RS01945	COG0633	Ferredoxin
JHW33_RS01945	COG3217	Mosc domain protein beta barrel domain protein
JHW33_RS01950	COG0116	Belongs to the methyltransferase superfamily
JHW33_RS01950	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW33_RS01955	COG0488	(ABC) transporter
JHW33_RS01960	COG2995	paraquat-inducible protein a
JHW33_RS01965	COG3008	intermembrane lipid transfer
JHW33_RS01965	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHW33_RS01970	COG3009	Protein conserved in bacteria
JHW33_RS01975	COG3130	regulation of translation
JHW33_RS01980	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHW33_RS01985	COG1067	ATP-dependent peptidase activity
JHW33_RS02000	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
JHW33_RS02005	COG3070	regulator of competence-specific genes
JHW33_RS02010	COG1289	transmembrane transporter activity
JHW33_RS02015	COG3304	Inner membrane component domain
JHW33_RS02020	COG0210	DNA helicase
JHW33_RS02025	COG1803	Methylglyoxal synthase
JHW33_RS02035	COG1832	CoA-binding protein
JHW33_RS02045	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JHW33_RS02050	COG1254	Belongs to the acylphosphatase family
JHW33_RS02055	COG2920	part of a sulfur-relay system
JHW33_RS02060	COG0670	Belongs to the BI1 family
JHW33_RS02095	COG3842	ATPase activity
JHW33_RS02100	COG0840	transmembrane signaling receptor activity
JHW33_RS02110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS02125	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW33_RS02130	COG1396	sequence-specific DNA binding
JHW33_RS02130	COG1917	Cupin 2, conserved barrel domain protein
JHW33_RS02135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHW33_RS02140	COG0174	glutamine synthetase
JHW33_RS02145	COG0531	amino acid
JHW33_RS02150	COG2925	Exonuclease
JHW33_RS02155	COG1289	transmembrane transporter activity
JHW33_RS02165	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW33_RS02175	COG2182	Extracellular solute-binding protein
JHW33_RS02180	COG1175	transmembrane transport
JHW33_RS02185	COG3833	ABC-type maltose transport systems, permease component
JHW33_RS02190	COG3867	Arabinogalactan endo-beta-1,4-galactanase
JHW33_RS02195	COG1874	Beta-galactosidase
JHW33_RS02200	COG1263	PTS System
JHW33_RS02200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS02210	COG1609	Transcriptional regulator
JHW33_RS02225	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
JHW33_RS02245	COG3052	prosthetic group binding
JHW33_RS02250	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
JHW33_RS02255	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW33_RS02260	COG3493	citrate carrier protein
JHW33_RS02270	COG4565	transcriptional regulatory protein
JHW33_RS02275	COG0534	Mate efflux family protein
JHW33_RS02280	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHW33_RS02285	COG0625	glutathione transferase activity
JHW33_RS02290	COG0477	Major facilitator Superfamily
JHW33_RS02335	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS02345	COG1621	beta-fructofuranosidase activity
JHW33_RS02350	COG2814	Major facilitator Superfamily
JHW33_RS02410	COG0604	alcohol dehydrogenase
JHW33_RS02415	COG0583	DNA-binding transcription factor activity
JHW33_RS02430	COG0667	Aldo Keto reductase
JHW33_RS02450	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHW33_RS02455	COG0386	Belongs to the glutathione peroxidase family
JHW33_RS02465	COG1178	ABC-type Fe3 transport system permease component
JHW33_RS02470	COG1840	ABC-type Fe3 transport system, periplasmic component
JHW33_RS02480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS02485	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS02490	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS02495	COG0601	transmembrane transport
JHW33_RS02500	COG0747	negative chemotaxis
JHW33_RS02515	COG0436	Aminotransferase
JHW33_RS02520	COG0504	CTP synthase activity
JHW33_RS02525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS02530	COG0006	proline dipeptidase activity
JHW33_RS02540	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW33_RS02550	COG0765	amino acid transport
JHW33_RS02555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS02560	COG1802	Transcriptional regulator
JHW33_RS02580	COG2879	small protein
JHW33_RS02585	COG1966	Carbon starvation protein
JHW33_RS02590	COG3678	ATP-independent chaperone mediated protein folding
JHW33_RS02595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS02600	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHW33_RS02600	COG0517	IMP dehydrogenase activity
JHW33_RS02605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHW33_RS02615	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS02620	COG1129	ABC transporter
JHW33_RS02635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
JHW33_RS02645	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS02650	COG3724	N-succinylarginine dihydrolase activity
JHW33_RS02680	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW33_RS02685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JHW33_RS02690	COG3381	protein complex oligomerization
JHW33_RS02700	COG2999	glutathione oxidoreductase activity
JHW33_RS02705	COG0477	Major facilitator Superfamily
JHW33_RS02710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW33_RS02720	COG0673	inositol 2-dehydrogenase activity
JHW33_RS02730	COG0018	arginyl-trna synthetase
JHW33_RS02735	COG3102	Protein conserved in bacteria
JHW33_RS02740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JHW33_RS02745	COG3142	Participates in the control of copper homeostasis
JHW33_RS02760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
JHW33_RS02765	COG2226	methyltransferase
JHW33_RS02770	COG3788	relative of glutathione S-transferase, MAPEG superfamily
JHW33_RS02775	COG1801	Protein of unknown function DUF72
JHW33_RS02780	COG1335	isochorismatase
JHW33_RS02785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JHW33_RS02790	COG0494	nUDIX hydrolase
JHW33_RS02795	COG0217	transcriptional regulatory protein
JHW33_RS02805	COG0632	four-way junction helicase activity
JHW33_RS02810	COG2255	four-way junction helicase activity
JHW33_RS02815	COG1472	Belongs to the glycosyl hydrolase 3 family
JHW33_RS02820	COG2211	Major facilitator Superfamily
JHW33_RS02825	COG0583	DNA-binding transcription factor activity
JHW33_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS02870	COG4221	oxidoreductase activity
JHW33_RS02890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS02910	COG0583	DNA-binding transcription factor activity
JHW33_RS02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS02925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHW33_RS02925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHW33_RS02935	COG0572	uridine kinase
JHW33_RS02940	COG0717	Belongs to the dCTP deaminase family
JHW33_RS02945	COG2982	Protein involved in outer membrane biogenesis
JHW33_RS02950	COG1253	flavin adenine dinucleotide binding
JHW33_RS02955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JHW33_RS03000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JHW33_RS03005	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS03015	COG1216	Glycosyl transferase, family 2
JHW33_RS03015	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS03060	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS03070	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JHW33_RS03075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
JHW33_RS03075	COG0140	phosphoribosyl-ATP diphosphatase activity
JHW33_RS03085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
JHW33_RS03095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHW33_RS03095	COG0131	Imidazoleglycerol-phosphate dehydratase
JHW33_RS03100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHW33_RS03105	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
JHW33_RS03110	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
JHW33_RS03115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW33_RS03140	COG2198	Histidine kinase
JHW33_RS03140	COG0643	Histidine kinase
JHW33_RS03145	COG0835	chemotaxis
JHW33_RS03150	COG0582	viral genome integration into host DNA
JHW33_RS03165	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
JHW33_RS03205	COG1802	Transcriptional regulator
JHW33_RS03205	COG4626	Terminase
JHW33_RS03235	COG1403	HNH endonuclease
JHW33_RS03260	COG3179	chitinase
JHW33_RS03310	COG0740	serine-type endopeptidase activity
JHW33_RS03350	COG1196	nuclear chromosome segregation
JHW33_RS03405	COG0477	Major facilitator Superfamily
JHW33_RS03420	COG0840	transmembrane signaling receptor activity
JHW33_RS03425	COG0840	transmembrane signaling receptor activity
JHW33_RS03430	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
JHW33_RS03440	COG0745	RESPONSE REGULATOR receiver
JHW33_RS03445	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
JHW33_RS03450	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JHW33_RS03455	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
JHW33_RS03465	COG3418	PFAM FlgN family protein
JHW33_RS03470	COG2747	anti-sigma28 factor FlgM
JHW33_RS03480	COG1815	bacterial-type flagellum-dependent cell motility
JHW33_RS03485	COG1558	bacterial-type flagellum-dependent cell motility
JHW33_RS03490	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
JHW33_RS03495	COG1749	Flagellar hook protein flgE
JHW33_RS03525	COG1256	bacterial-type flagellum assembly
JHW33_RS03535	COG1346	cytolysis
JHW33_RS03540	COG1380	Effector of murein hydrolase LrgA
JHW33_RS03545	COG1126	abc transporter atp-binding protein
JHW33_RS03550	COG0765	amino acid transport
JHW33_RS03565	COG1473	amidohydrolase
JHW33_RS03570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS03575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS03580	COG1309	transcriptional regulator
JHW33_RS03585	COG0604	alcohol dehydrogenase
JHW33_RS03590	COG0784	Response regulator, receiver
JHW33_RS03590	COG0835	chemotaxis
JHW33_RS03610	COG1234	tRNA 3'-trailer cleavage
JHW33_RS03620	COG0583	DNA-binding transcription factor activity
JHW33_RS03625	COG2079	MmgE PrpD family protein
JHW33_RS03640	COG0477	Major facilitator Superfamily
JHW33_RS03650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS03665	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW33_RS03685	COG0251	oxidation-reduction process
JHW33_RS03690	COG0402	S-adenosylhomocysteine deaminase activity
JHW33_RS03700	COG0583	DNA-binding transcription factor activity
JHW33_RS03725	COG3122	Protein conserved in bacteria
JHW33_RS03735	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS03775	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS03790	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
JHW33_RS03795	COG0747	negative chemotaxis
JHW33_RS03800	COG0601	transmembrane transport
JHW33_RS03805	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS03810	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS03815	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS03825	COG2828	Protein conserved in bacteria
JHW33_RS03830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW33_RS03835	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
JHW33_RS03840	COG0583	DNA-binding transcription factor activity
JHW33_RS03845	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS03855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHW33_RS03865	COG3384	dioxygenase
JHW33_RS03875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHW33_RS03885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS03890	COG0601	transmembrane transport
JHW33_RS03895	COG0747	negative chemotaxis
JHW33_RS03900	COG1940	carbohydrate kinase activity
JHW33_RS03910	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS03925	COG0788	formyltetrahydrofolate deformylase activity
JHW33_RS03935	COG1752	Esterase of the alpha-beta hydrolase superfamily
JHW33_RS03940	COG0745	RESPONSE REGULATOR receiver
JHW33_RS03960	COG1435	thymidine kinase activity
JHW33_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS03965	COG1454	alcohol dehydrogenase
JHW33_RS03970	COG2095	MarC family integral membrane protein
JHW33_RS03990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS03995	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS04005	COG3099	Belongs to the UPF0263 family
JHW33_RS04010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW33_RS04030	COG2350	Protein conserved in bacteria
JHW33_RS04040	COG3385	transposase activity
JHW33_RS04045	COG1607	acyl-coa hydrolase
JHW33_RS04050	COG2917	probably involved in intracellular septation
JHW33_RS04060	COG0727	PFAM Uncharacterised protein family (UPF0153)
JHW33_RS04065	COG3047	cAMP biosynthetic process
JHW33_RS04075	COG0159	tryptophan synthase activity
JHW33_RS04080	COG0133	tryptophan synthase activity
JHW33_RS04090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
JHW33_RS04105	COG0613	PHP domain protein
JHW33_RS04110	COG0009	L-threonylcarbamoyladenylate synthase
JHW33_RS04115	COG1187	pseudouridine synthase activity
JHW33_RS04130	COG0406	alpha-ribazole phosphatase activity
JHW33_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS04150	COG0616	signal peptide processing
JHW33_RS04165	COG0583	DNA-binding transcription factor activity
JHW33_RS04180	COG0671	phosphoesterase, PA-phosphatase related
JHW33_RS04185	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
JHW33_RS04190	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
JHW33_RS04205	COG0023	Translation Initiation Factor
JHW33_RS04215	COG0235	Class ii aldolase
JHW33_RS04220	COG1349	DNA-binding transcription factor activity
JHW33_RS04225	COG1882	Formate acetyltransferase
JHW33_RS04230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHW33_RS04245	COG1070	Carbohydrate kinase
JHW33_RS04250	COG2390	Transcriptional regulator
JHW33_RS04255	COG1129	ABC transporter
JHW33_RS04265	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS04275	COG1830	Aldolase
JHW33_RS04280	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHW33_RS04285	COG1070	Carbohydrate kinase
JHW33_RS04290	COG2115	Belongs to the xylose isomerase family
JHW33_RS04295	COG4213	ABC transporter substrate-binding protein
JHW33_RS04305	COG4214	carbohydrate transport
JHW33_RS04310	COG1609	Transcriptional regulator
JHW33_RS04310	COG2207	Transcriptional regulator
JHW33_RS04315	COG1501	Belongs to the glycosyl hydrolase 31 family
JHW33_RS04320	COG2211	Major facilitator Superfamily
JHW33_RS04330	COG2133	pyrroloquinoline quinone binding
JHW33_RS04355	COG3136	membrane protein required for alginate biosynthesis
JHW33_RS04360	COG1686	Belongs to the peptidase S11 family
JHW33_RS04365	COG3385	transposase activity
JHW33_RS04370	COG0671	phosphoesterase, PA-phosphatase related
JHW33_RS04415	COG2985	domain, Protein
JHW33_RS04415	COG0569	domain protein
JHW33_RS04435	COG0189	ligase activity
JHW33_RS04445	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHW33_RS04450	COG3842	ATPase activity
JHW33_RS04455	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW33_RS04460	COG1177	transmembrane transport
JHW33_RS04470	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW33_RS04480	COG1987	bacterial-type flagellum assembly
JHW33_RS04485	COG1338	Plays a role in the flagellum-specific transport system
JHW33_RS04510	COG3144	bacterial-type flagellum assembly
JHW33_RS04515	COG2882	bacterial-type flagellum organization
JHW33_RS04535	COG1766	The M ring may be actively involved in energy transduction
JHW33_RS04540	COG1677	Flagellar hook-basal body complex protein FliE
JHW33_RS04550	COG3781	membrane
JHW33_RS04595	COG0401	homolog of Blt101
JHW33_RS04630	COG1191	sigma factor activity
JHW33_RS04645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS04650	COG0765	amino acid transport
JHW33_RS04655	COG1126	abc transporter atp-binding protein
JHW33_RS04660	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JHW33_RS04660	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
JHW33_RS04660	COG0506	proline dehydrogenase activity
JHW33_RS04670	COG0672	)-iron permease
JHW33_RS04675	COG2822	iron ion transport
JHW33_RS04685	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHW33_RS04695	COG1702	phosphate starvation-inducible protein PhoH
JHW33_RS04700	COG0387	Pfam Sodium calcium exchanger
JHW33_RS04705	COG4572	Cation transport regulator
JHW33_RS04710	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
JHW33_RS04720	COG0601	transmembrane transport
JHW33_RS04725	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS04730	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS04735	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS04740	COG4166	transmembrane transport
JHW33_RS04745	COG3093	addiction module antidote protein HigA
JHW33_RS04750	COG3549	Plasmid maintenance system killer
JHW33_RS04755	COG0038	chloride channel
JHW33_RS04765	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
JHW33_RS04770	COG1140	nitrate reductase beta subunit
JHW33_RS04775	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
JHW33_RS04780	COG2181	nitrate reductase activity
JHW33_RS04790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS04805	COG1132	(ABC) transporter
JHW33_RS04820	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS04830	COG0747	negative chemotaxis
JHW33_RS04835	COG0601	transmembrane transport
JHW33_RS04840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS04855	COG0583	DNA-binding transcription factor activity
JHW33_RS04860	COG0371	Dehydrogenase
JHW33_RS04865	COG1737	Transcriptional regulator
JHW33_RS04870	COG0477	Major facilitator Superfamily
JHW33_RS04885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS04905	COG0747	negative chemotaxis
JHW33_RS04910	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS04915	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS04925	COG5001	Diguanylate cyclase
JHW33_RS04925	COG3300	MHYT domain
JHW33_RS04930	COG1609	Transcriptional regulator
JHW33_RS04935	COG1263	PTS System
JHW33_RS04935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS04940	COG2723	6-phospho-beta-galactosidase activity
JHW33_RS04955	COG3707	response regulator
JHW33_RS04960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
JHW33_RS04970	COG1116	anion transmembrane transporter activity
JHW33_RS04975	COG2146	nitrite reductase [NAD(P)H] activity
JHW33_RS04975	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW33_RS04980	COG0243	molybdopterin cofactor binding
JHW33_RS04985	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHW33_RS04985	COG1648	precorrin-2 dehydrogenase activity
JHW33_RS04990	COG0456	acetyltransferase
JHW33_RS05005	COG0583	DNA-binding transcription factor activity
JHW33_RS05025	COG3188	usher protein
JHW33_RS05035	COG3423	Transcriptional regulator
JHW33_RS05040	COG3423	Transcriptional regulator
JHW33_RS05045	COG1741	Belongs to the pirin family
JHW33_RS05050	COG0583	DNA-binding transcription factor activity
JHW33_RS05060	COG2207	Transcriptional regulator
JHW33_RS05070	COG1174	glycine betaine transport
JHW33_RS05085	COG2986	histidine ammonia-lyase
JHW33_RS05095	COG2188	Transcriptional regulator
JHW33_RS05100	COG1064	alcohol dehydrogenase
JHW33_RS05105	COG0697	spore germination
JHW33_RS05130	COG3265	gluconokinase activity
JHW33_RS05135	COG2610	gluconate transmembrane transporter activity
JHW33_RS05140	COG0129	dihydroxy-acid dehydratase activity
JHW33_RS05145	COG0800	Aldolase
JHW33_RS05175	COG2837	iron assimilation
JHW33_RS05180	COG3547	Transposase (IS116 IS110 IS902 family)
JHW33_RS05200	COG0745	RESPONSE REGULATOR receiver
JHW33_RS05230	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS05270	COG0601	transmembrane transport
JHW33_RS05275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS05285	COG1802	Transcriptional regulator
JHW33_RS05305	COG0583	DNA-binding transcription factor activity
JHW33_RS05320	COG4215	(ABC) transporter
JHW33_RS05325	COG0765	amino acid transport
JHW33_RS05340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS05355	COG5001	Diguanylate cyclase
JHW33_RS05355	COG3300	MHYT domain
JHW33_RS05360	COG0778	Nitroreductase
JHW33_RS05365	COG3459	Glycosyltransferase 36 associated
JHW33_RS05370	COG0745	RESPONSE REGULATOR receiver
JHW33_RS05375	COG5002	protein histidine kinase activity
JHW33_RS05390	COG0012	GTP binding
JHW33_RS05395	COG0659	secondary active sulfate transmembrane transporter activity
JHW33_RS05405	COG0330	HflC and HflK could
JHW33_RS05415	COG2217	Heavy metal translocating P-type atpase
JHW33_RS05420	COG0193	aminoacyl-tRNA hydrolase activity
JHW33_RS05430	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JHW33_RS05445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
JHW33_RS05450	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JHW33_RS05455	COG2890	protein-(glutamine-N5) methyltransferase activity
JHW33_RS05470	COG2877	3-deoxy-8-phosphooctulonate synthase activity
JHW33_RS05475	COG0659	secondary active sulfate transmembrane transporter activity
JHW33_RS05505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHW33_RS05505	COG0493	'glutamate synthase
JHW33_RS05515	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS05520	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS05525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS05530	COG0601	transmembrane transport
JHW33_RS05550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
JHW33_RS05555	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
JHW33_RS05560	COG0589	response to stress
JHW33_RS05565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHW33_RS05575	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS05585	COG2840	Smr protein MutS2
JHW33_RS05590	COG1477	protein flavinylation
JHW33_RS05600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW33_RS05605	COG0583	DNA-binding transcription factor activity
JHW33_RS05610	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
JHW33_RS05615	COG0243	molybdopterin cofactor binding
JHW33_RS05640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS05645	COG0583	DNA-binding transcription factor activity
JHW33_RS05675	COG1742	UPF0060 membrane protein
JHW33_RS05685	COG2252	PERMEase
JHW33_RS05690	COG4221	oxidoreductase activity
JHW33_RS05695	COG0667	Aldo Keto reductase
JHW33_RS05700	COG3842	ATPase activity
JHW33_RS05705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS05720	COG2182	Extracellular solute-binding protein
JHW33_RS05725	COG1940	carbohydrate kinase activity
JHW33_RS05735	COG0402	S-adenosylhomocysteine deaminase activity
JHW33_RS05750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
JHW33_RS05760	COG3842	ATPase activity
JHW33_RS05765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JHW33_RS05770	COG1178	ABC-type Fe3 transport system permease component
JHW33_RS05780	COG2186	Transcriptional regulator
JHW33_RS05785	COG0390	transport system, permease component
JHW33_RS05790	COG4619	ABC transporter
JHW33_RS05795	COG5339	Protein conserved in bacteria
JHW33_RS05800	COG1482	cell wall glycoprotein biosynthetic process
JHW33_RS05805	COG0114	fumarate hydratase activity
JHW33_RS05820	COG2818	Glycosylase
JHW33_RS05825	COG3097	Belongs to the UPF0267 family
JHW33_RS05850	COG4977	sequence-specific DNA binding
JHW33_RS05855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHW33_RS05875	COG2084	Dehydrogenase
JHW33_RS05885	COG1609	Transcriptional regulator
JHW33_RS05890	COG1263	PTS System
JHW33_RS05890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS05895	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JHW33_RS05900	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JHW33_RS05905	COG0385	Bile acid
JHW33_RS05910	COG0673	inositol 2-dehydrogenase activity
JHW33_RS05915	COG2079	MmgE PrpD family protein
JHW33_RS05925	COG0726	polysaccharide deacetylase
JHW33_RS05940	COG0765	amino acid transport
JHW33_RS05945	COG0165	Argininosuccinate lyase
JHW33_RS05960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW33_RS05980	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS05995	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JHW33_RS06000	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
JHW33_RS06005	COG2986	histidine ammonia-lyase
JHW33_RS06030	COG0402	S-adenosylhomocysteine deaminase activity
JHW33_RS06040	COG1228	amidohydrolase
JHW33_RS06050	COG3118	belongs to the thioredoxin family
JHW33_RS06050	COG0457	Tetratricopeptide repeat
JHW33_RS06055	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS06060	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS06085	COG2194	sulfuric ester hydrolase activity
JHW33_RS06090	COG2186	Transcriptional regulator
JHW33_RS06095	COG1312	Catalyzes the dehydration of D-mannonate
JHW33_RS06105	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS06110	COG1129	ABC transporter
JHW33_RS06115	COG1879	ABC-type sugar transport system periplasmic component
JHW33_RS06135	COG1840	ABC-type Fe3 transport system, periplasmic component
JHW33_RS06140	COG4149	molybdate abc transporter
JHW33_RS06145	COG0477	Major facilitator Superfamily
JHW33_RS06160	COG1940	carbohydrate kinase activity
JHW33_RS06165	COG0583	DNA-binding transcription factor activity
JHW33_RS06170	COG2814	Major facilitator Superfamily
JHW33_RS06175	COG3842	ATPase activity
JHW33_RS06180	COG0395	ABC-type sugar transport system, permease component
JHW33_RS06185	COG1175	transmembrane transport
JHW33_RS06205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW33_RS06210	COG3069	C4-dicarboxylate transmembrane transporter activity
JHW33_RS06220	COG4657	Part of a membrane complex involved in electron transport
JHW33_RS06225	COG2878	Part of a membrane complex involved in electron transport
JHW33_RS06230	COG4656	Part of a membrane complex involved in electron transport
JHW33_RS06240	COG4659	FMN binding
JHW33_RS06250	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JHW33_RS06280	COG2223	nitrite transmembrane transporter activity
JHW33_RS06285	COG3850	Histidine kinase
JHW33_RS06290	COG2197	response regulator
JHW33_RS06295	COG4932	domain protein
JHW33_RS06320	COG0745	RESPONSE REGULATOR receiver
JHW33_RS06325	COG2205	protein histidine kinase activity
JHW33_RS06330	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JHW33_RS06340	COG3591	Belongs to the peptidase S1B family
JHW33_RS06345	COG1643	Atp-dependent helicase
JHW33_RS06375	COG3784	Protein of unknown function (DUF1318)
JHW33_RS06385	COG2911	Protein conserved in bacteria
JHW33_RS06390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW33_RS06400	COG0395	ABC-type sugar transport system, permease component
JHW33_RS06405	COG1175	transmembrane transport
JHW33_RS06410	COG1653	transport
JHW33_RS06415	COG3842	ATPase activity
JHW33_RS06430	COG1013	pyruvate-flavodoxin oxidoreductase activity
JHW33_RS06430	COG0674	pyruvate-flavodoxin oxidoreductase activity
JHW33_RS06430	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
JHW33_RS06430	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JHW33_RS06435	COG3250	beta-galactosidase activity
JHW33_RS06445	COG4977	sequence-specific DNA binding
JHW33_RS06450	COG2186	Transcriptional regulator
JHW33_RS06455	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS06485	COG0037	tRNA processing
JHW33_RS06500	COG0583	DNA-binding transcription factor activity
JHW33_RS06505	COG2814	Major facilitator Superfamily
JHW33_RS06510	COG4166	transmembrane transport
JHW33_RS06515	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS06520	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
JHW33_RS06530	COG0708	Exodeoxyribonuclease III
JHW33_RS06535	COG0494	nUDIX hydrolase
JHW33_RS06545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JHW33_RS06550	COG0778	Nitroreductase
JHW33_RS06555	COG0616	signal peptide processing
JHW33_RS06560	COG0252	asparaginase activity
JHW33_RS06565	COG1335	isochorismatase
JHW33_RS06570	COG3139	Protein of unknown function (DUF1315)
JHW33_RS06575	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS06585	COG0676	glucose-6-phosphate 1-epimerase activity
JHW33_RS06590	COG0656	L-ascorbic acid biosynthetic process
JHW33_RS06595	COG3713	MltA-interacting MipA family protein
JHW33_RS06600	COG2766	serine protein kinase
JHW33_RS06605	COG2718	Belongs to the UPF0229 family
JHW33_RS06630	COG3137	Salt-induced outer membrane protein
JHW33_RS06650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JHW33_RS06665	COG2719	SpoVR family
JHW33_RS06670	COG2186	Transcriptional regulator
JHW33_RS06675	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHW33_RS06680	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
JHW33_RS06690	COG0628	permease
JHW33_RS06700	COG2983	Belongs to the UPF0260 family
JHW33_RS06705	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW33_RS06710	COG2951	lytic endotransglycosylase activity
JHW33_RS06715	COG3100	YcgL domain-containing protein
JHW33_RS06720	COG0850	regulation of cytokinetic process
JHW33_RS06725	COG2894	cell division
JHW33_RS06730	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
JHW33_RS06735	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
JHW33_RS06740	COG0318	PFAM AMP-dependent synthetase and ligase
JHW33_RS06745	COG3065	identical protein binding
JHW33_RS06755	COG1199	ATP-dependent helicase activity
JHW33_RS06760	COG0251	oxidation-reduction process
JHW33_RS06765	COG0800	Aldolase
JHW33_RS06770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JHW33_RS06775	COG1737	Transcriptional regulator
JHW33_RS06780	COG0469	pyruvate kinase activity
JHW33_RS06785	COG0076	glutamate decarboxylase activity
JHW33_RS06790	COG3486	L-lysine 6-monooxygenase (NADPH) activity
JHW33_RS06805	COG1560	Kdo2-lipid A biosynthetic process
JHW33_RS06810	COG0739	heme binding
JHW33_RS06815	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
JHW33_RS06825	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW33_RS06860	COG0655	NAD(P)H dehydrogenase (quinone) activity
JHW33_RS06875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHW33_RS06880	COG0640	Transcriptional regulator
JHW33_RS06910	COG4774	siderophore transport
JHW33_RS06930	COG1376	ErfK ybiS ycfS ynhG family protein
JHW33_RS06945	COG1566	PFAM secretion protein HlyD family protein
JHW33_RS06950	COG2814	Major facilitator Superfamily
JHW33_RS06960	COG2207	Transcriptional regulator
JHW33_RS06965	COG0300	oxidoreductase activity
JHW33_RS06970	COG0598	Magnesium transport protein CorA
JHW33_RS06990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW33_RS06995	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS07000	COG1196	nuclear chromosome segregation
JHW33_RS07000	COG3264	Mechanosensitive ion channel
JHW33_RS07010	COG4615	Cyclic peptide transporter
JHW33_RS07015	COG2271	Major facilitator Superfamily
JHW33_RS07025	COG2733	membrane
JHW33_RS07040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
JHW33_RS07045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
JHW33_RS07060	COG2211	Major facilitator Superfamily
JHW33_RS07075	COG0840	transmembrane signaling receptor activity
JHW33_RS07090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHW33_RS07110	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHW33_RS07130	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW33_RS07145	COG3479	Phenolic acid decarboxylase
JHW33_RS07150	COG0596	Alpha beta hydrolase
JHW33_RS07155	COG2200	EAL domain
JHW33_RS07160	COG3228	Belongs to the MtfA family
JHW33_RS07170	COG0366	Alpha amylase catalytic
JHW33_RS07175	COG0366	Alpha amylase catalytic
JHW33_RS07180	COG3842	ATPase activity
JHW33_RS07200	COG1653	transport
JHW33_RS07205	COG0583	DNA-binding transcription factor activity
JHW33_RS07215	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW33_RS07225	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS07230	COG0800	Aldolase
JHW33_RS07235	COG3734	2-keto-3-deoxy-galactonokinase
JHW33_RS07240	COG2186	Transcriptional regulator
JHW33_RS07255	COG5002	protein histidine kinase activity
JHW33_RS07260	COG0745	RESPONSE REGULATOR receiver
JHW33_RS07275	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS07315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS07340	COG2814	Major facilitator Superfamily
JHW33_RS07345	COG0697	spore germination
JHW33_RS07350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS07355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHW33_RS07360	COG1984	allophanate hydrolase subunit 2
JHW33_RS07380	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHW33_RS07385	COG4221	oxidoreductase activity
JHW33_RS07390	COG0765	amino acid transport
JHW33_RS07395	COG0765	amino acid transport
JHW33_RS07405	COG2315	Protein conserved in bacteria
JHW33_RS07435	COG4974	Belongs to the 'phage' integrase family
JHW33_RS07470	COG2200	EAL domain
JHW33_RS07570	COG0582	viral genome integration into host DNA
JHW33_RS07590	COG2011	ABC-type metal ion transport system permease component
JHW33_RS07615	COG0411	ABC transporter
JHW33_RS07625	COG0559	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS07640	COG0840	transmembrane signaling receptor activity
JHW33_RS07645	COG0113	porphobilinogen synthase activity
JHW33_RS07685	COG3768	UPF0283 membrane protein
JHW33_RS07690	COG3106	COG3106 Predicted ATPase
JHW33_RS07700	COG1983	PspC domain protein
JHW33_RS07710	COG1842	Phage shock protein A
JHW33_RS07715	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JHW33_RS07735	COG4171	peptide transport system, permease
JHW33_RS07740	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS07745	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS07750	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW33_RS07750	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW33_RS07755	COG3104	oligopeptide transport
JHW33_RS07765	COG5001	Diguanylate cyclase
JHW33_RS07765	COG5002	protein histidine kinase activity
JHW33_RS07765	COG3447	MASE1 domain protein
JHW33_RS07785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS07790	COG0625	glutathione transferase activity
JHW33_RS07800	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JHW33_RS07805	COG0259	pyridoxamine-phosphate oxidase activity
JHW33_RS07810	COG3895	Periplasmic Protein
JHW33_RS07815	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
JHW33_RS07825	COG1846	Transcriptional regulator
JHW33_RS07835	COG1566	PFAM secretion protein HlyD family protein
JHW33_RS07840	COG1289	transmembrane transporter activity
JHW33_RS07845	COG4989	oxidoreductase activity
JHW33_RS07850	COG3313	Fe-S protein
JHW33_RS07855	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS07865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW33_RS07870	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
JHW33_RS07875	COG0791	NLP P60 protein
JHW33_RS07890	COG0583	DNA-binding transcription factor activity
JHW33_RS07895	COG2814	Major facilitator Superfamily
JHW33_RS07900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHW33_RS07905	COG0307	riboflavin synthase, alpha
JHW33_RS07910	COG0534	Mate efflux family protein
JHW33_RS07935	COG1388	LysM domain
JHW33_RS07935	COG1376	ErfK ybiS ycfS ynhG family protein
JHW33_RS07940	COG2166	iron-sulfur cluster assembly
JHW33_RS07945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHW33_RS07950	COG0719	Fe-S assembly protein
JHW33_RS07955	COG0396	ATPase activity
JHW33_RS07960	COG0719	Fe-S assembly protein
JHW33_RS07965	COG0316	Belongs to the HesB IscA family
JHW33_RS07975	COG2050	protein possibly involved in aromatic compounds catabolism
JHW33_RS07980	COG0277	FAD linked oxidase domain protein
JHW33_RS07980	COG0247	lactate metabolic process
JHW33_RS07985	COG0628	permease
JHW33_RS07995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW33_RS07995	COG0574	Belongs to the PEP-utilizing enzyme family
JHW33_RS08010	COG3720	iron ion transport
JHW33_RS08015	COG4558	Periplasmic binding protein
JHW33_RS08020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW33_RS08025	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
JHW33_RS08040	COG0095	Lipoate-protein ligase
JHW33_RS08045	COG0791	NLP P60 protein
JHW33_RS08050	COG2076	Multidrug Resistance protein
JHW33_RS08055	COG2076	Multidrug Resistance protein
JHW33_RS08060	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
JHW33_RS08065	COG0726	polysaccharide deacetylase
JHW33_RS08070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW33_RS08070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW33_RS08075	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS08080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW33_RS08090	COG0386	Belongs to the glutathione peroxidase family
JHW33_RS08095	COG4139	cobalamin transport
JHW33_RS08110	COG0776	regulation of translation
JHW33_RS08115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JHW33_RS08115	COG0072	phenylalanine-tRNA ligase activity
JHW33_RS08130	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JHW33_RS08145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JHW33_RS08160	COG3001	Fructosamine kinase
JHW33_RS08170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW33_RS08180	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS08185	COG1988	membrane-bound metal-dependent
JHW33_RS08190	COG1823	symporter activity
JHW33_RS08200	COG2814	Major facilitator Superfamily
JHW33_RS08205	COG0501	Belongs to the peptidase M48B family
JHW33_RS08215	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
JHW33_RS08220	COG1956	GAF domain-containing protein
JHW33_RS08225	COG2995	paraquat-inducible protein a
JHW33_RS08230	COG3008	intermembrane lipid transfer
JHW33_RS08235	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHW33_RS08235	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JHW33_RS08240	COG3706	GGDEF domain
JHW33_RS08240	COG2203	Gaf domain
JHW33_RS08240	COG5001	Diguanylate cyclase
JHW33_RS08240	COG4251	negative regulation of phosphorylation
JHW33_RS08275	COG1473	amidohydrolase
JHW33_RS08290	COG0840	transmembrane signaling receptor activity
JHW33_RS08295	COG2015	COG2015, Alkyl sulfatase and related hydrolases
JHW33_RS08305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JHW33_RS08445	COG3385	transposase activity
JHW33_RS08475	COG3385	transposase activity
JHW33_RS08610	COG1276	copper resistance
JHW33_RS08615	COG2372	response to copper ion
JHW33_RS08620	COG1528	Iron-storage protein
JHW33_RS08635	COG1770	oligopeptidase
JHW33_RS08645	COG0513	Belongs to the DEAD box helicase family
JHW33_RS08650	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
JHW33_RS08655	COG3140	Belongs to the UPF0181 family
JHW33_RS08665	COG0494	nUDIX hydrolase
JHW33_RS08670	COG1760	l-serine dehydratase
JHW33_RS08675	COG2200	EAL domain
JHW33_RS08680	COG1253	flavin adenine dinucleotide binding
JHW33_RS08685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS08685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS08690	COG3715	PTS system
JHW33_RS08695	COG3716	PTS system mannose fructose sorbose family IID component
JHW33_RS08700	COG4811	Protein of unknown function (DUF986)
JHW33_RS08705	COG1971	Probably functions as a manganese efflux pump
JHW33_RS08710	COG2226	methyltransferase
JHW33_RS08715	COG1496	oxidoreductase activity
JHW33_RS08760	COG3468	outer membrane autotransporter barrel domain protein
JHW33_RS08805	COG0538	isocitrate dehydrogenase activity
JHW33_RS08810	COG1187	pseudouridine synthase activity
JHW33_RS08825	COG2915	High frequency lysogenization protein hflD homolog
JHW33_RS08830	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JHW33_RS08835	COG0745	RESPONSE REGULATOR receiver
JHW33_RS08845	COG2850	peptidyl-arginine hydroxylation
JHW33_RS08860	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHW33_RS08870	COG4591	ABC-type transport system involved in lipoprotein release permease component
JHW33_RS08875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JHW33_RS08880	COG3134	Outer membrane lipoprotein
JHW33_RS08885	COG1252	NADH dehydrogenase
JHW33_RS08890	COG3150	esterase
JHW33_RS08905	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
JHW33_RS08915	COG0537	adenosine 5'-monophosphoramidase activity
JHW33_RS08920	COG1263	PTS System
JHW33_RS08920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS08925	COG0084	hydrolase, TatD family'
JHW33_RS08930	COG0470	DNA polymerase III
JHW33_RS08935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JHW33_RS08940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JHW33_RS08945	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS08950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW33_RS08955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW33_RS08965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JHW33_RS08970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHW33_RS08975	COG0416	fatty acid biosynthetic process
JHW33_RS08980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JHW33_RS08985	COG1399	metal-binding, possibly nucleic acid-binding protein
JHW33_RS08990	COG0424	maF-like protein
JHW33_RS08995	COG0564	pseudouridine synthase activity
JHW33_RS09000	COG1530	ribonuclease E activity
JHW33_RS09010	COG0418	dihydroorotase activity
JHW33_RS09035	COG0628	permease
JHW33_RS09050	COG3038	cytochrome b561
JHW33_RS09055	COG2353	YceI-like domain
JHW33_RS09060	COG1054	Belongs to the UPF0176 family
JHW33_RS09065	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS09070	COG1560	Kdo2-lipid A biosynthetic process
JHW33_RS09080	COG2814	Major facilitator Superfamily
JHW33_RS09100	COG5645	(Lipo)protein
JHW33_RS09105	COG2943	transferase activity, transferring hexosyl groups
JHW33_RS09110	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
JHW33_RS09175	COG1349	DNA-binding transcription factor activity
JHW33_RS09205	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JHW33_RS09210	COG0322	excinuclease ABC activity
JHW33_RS09215	COG2197	response regulator
JHW33_RS09235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHW33_RS09255	COG1113	amino acid transport
JHW33_RS09270	COG1309	transcriptional regulator
JHW33_RS09275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS09280	COG1335	isochorismatase
JHW33_RS09285	COG0251	oxidation-reduction process
JHW33_RS09290	COG2267	carboxylic ester hydrolase activity
JHW33_RS09295	COG0778	Nitroreductase
JHW33_RS09300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JHW33_RS09305	COG2233	PERMEase
JHW33_RS09310	COG0747	negative chemotaxis
JHW33_RS09315	COG0601	transmembrane transport
JHW33_RS09320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS09325	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS09330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS09345	COG1129	ABC transporter
JHW33_RS09350	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS09355	COG0456	acetyltransferase
JHW33_RS09355	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
JHW33_RS09365	COG0789	Transcriptional regulator
JHW33_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS09390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JHW33_RS09410	COG0697	spore germination
JHW33_RS09420	COG1174	glycine betaine transport
JHW33_RS09425	COG1125	glycine betaine transport
JHW33_RS09430	COG1174	glycine betaine transport
JHW33_RS09435	COG1732	Glycine betaine
JHW33_RS09440	COG2814	Major facilitator Superfamily
JHW33_RS09450	COG0583	DNA-binding transcription factor activity
JHW33_RS09460	COG1473	amidohydrolase
JHW33_RS09465	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
JHW33_RS09475	COG1309	transcriptional regulator
JHW33_RS09510	COG1181	Belongs to the D-alanine--D-alanine ligase family
JHW33_RS09520	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS09525	COG2850	peptidyl-arginine hydroxylation
JHW33_RS09530	COG3639	organic phosphonate transmembrane transporter activity
JHW33_RS09550	COG0277	FAD linked oxidase domain protein
JHW33_RS09570	COG1686	Belongs to the peptidase S11 family
JHW33_RS09575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHW33_RS09590	COG0513	Belongs to the DEAD box helicase family
JHW33_RS09600	COG0670	Belongs to the BI1 family
JHW33_RS09610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
JHW33_RS09620	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHW33_RS09625	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
JHW33_RS09640	COG4628	conserved protein (DUF2132)
JHW33_RS09645	COG0556	nucleotide-excision repair
JHW33_RS09660	COG2226	methyltransferase
JHW33_RS09670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
JHW33_RS09685	COG0436	Aminotransferase
JHW33_RS09695	COG3700	Belongs to the class B bacterial acid phosphatase family
JHW33_RS09700	COG2130	NADP-dependent
JHW33_RS09710	COG1881	PFAM PEBP family protein
JHW33_RS09715	COG4677	pectinesterase activity
JHW33_RS09725	COG2706	6-phosphogluconolactonase activity
JHW33_RS09730	COG0561	phosphatase activity
JHW33_RS09735	COG3423	Transcriptional regulator
JHW33_RS09750	COG4149	molybdate abc transporter
JHW33_RS09755	COG0725	ABC transporter, periplasmic molybdate-binding protein
JHW33_RS09765	COG3585	molybdate ion transport
JHW33_RS09765	COG2005	Transcriptional regulator
JHW33_RS09770	COG1119	ATPase activity
JHW33_RS09785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JHW33_RS09790	COG1085	galactose-1-phosphate uridylyltransferase
JHW33_RS09795	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JHW33_RS09800	COG2017	converts alpha-aldose to the beta-anomer
JHW33_RS09810	COG0588	phosphoglycerate mutase activity
JHW33_RS09820	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHW33_RS09840	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
JHW33_RS09865	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
JHW33_RS09870	COG2885	chlorophyll binding
JHW33_RS09875	COG0823	Involved in the tonB-independent uptake of proteins
JHW33_RS09880	COG3064	Membrane
JHW33_RS09885	COG0848	biopolymer transport protein
JHW33_RS09890	COG0811	peptide transport
JHW33_RS09895	COG0824	Thioesterase
JHW33_RS09900	COG3790	cyd operon protein YbgE
JHW33_RS09905	COG4890	Cyd operon protein YbgT
JHW33_RS09910	COG1294	oxidase, subunit
JHW33_RS09915	COG1271	oxidase subunit
JHW33_RS09920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JHW33_RS09930	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHW33_RS09935	COG0567	Dehydrogenase, E1 component
JHW33_RS09940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHW33_RS09950	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
JHW33_RS09955	COG2009	succinate dehydrogenase
JHW33_RS09960	COG0372	Belongs to the citrate synthase family
JHW33_RS09975	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JHW33_RS09980	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
JHW33_RS09985	COG1984	allophanate hydrolase subunit 2
JHW33_RS09990	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
JHW33_RS10000	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JHW33_RS10005	COG5212	phosphodiesterase
JHW33_RS10010	COG0415	Belongs to the DNA photolyase family
JHW33_RS10015	COG3272	Protein of unknown function (DUF1722)
JHW33_RS10035	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
JHW33_RS10040	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
JHW33_RS10045	COG2205	protein histidine kinase activity
JHW33_RS10050	COG0745	RESPONSE REGULATOR receiver
JHW33_RS10055	COG1695	Transcriptional regulator
JHW33_RS10060	COG0033	Phosphoglucomutase
JHW33_RS10065	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
JHW33_RS10070	COG0596	Alpha beta hydrolase
JHW33_RS10085	COG0716	FMN binding
JHW33_RS10090	COG0735	belongs to the Fur family
JHW33_RS10105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JHW33_RS10110	COG2190	(PTS) system
JHW33_RS10110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS10110	COG1263	PTS System
JHW33_RS10115	COG0363	glucosamine-6-phosphate deaminase activity
JHW33_RS10120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JHW33_RS10125	COG1940	carbohydrate kinase activity
JHW33_RS10125	COG1846	Transcriptional regulator
JHW33_RS10130	COG0647	UMP catabolic process
JHW33_RS10135	COG0367	asparagine synthase
JHW33_RS10170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW33_RS10175	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JHW33_RS10180	COG1702	phosphate starvation-inducible protein PhoH
JHW33_RS10185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JHW33_RS10190	COG4535	Mg2 and Co2 transporter CorC
JHW33_RS10195	COG0815	Transfers the fatty acyl group on membrane lipoproteins
JHW33_RS10205	COG0765	amino acid transport
JHW33_RS10210	COG0765	amino acid transport
JHW33_RS10215	COG1126	abc transporter atp-binding protein
JHW33_RS10220	COG2888	peptidyl-tyrosine sulfation
JHW33_RS10225	COG0495	leucyl-tRNA aminoacylation
JHW33_RS10230	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
JHW33_RS10235	COG1466	dna polymerase III delta subunit
JHW33_RS10240	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JHW33_RS10245	COG0799	negative regulation of ribosome biogenesis
JHW33_RS10250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JHW33_RS10255	COG0768	penicillin binding
JHW33_RS10260	COG0772	Belongs to the SEDS family
JHW33_RS10265	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHW33_RS10270	COG1686	Belongs to the peptidase S11 family
JHW33_RS10275	COG2921	Belongs to the UPF0250 family
JHW33_RS10285	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
JHW33_RS10290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
JHW33_RS10295	COG1126	abc transporter atp-binding protein
JHW33_RS10300	COG0765	amino acid transport
JHW33_RS10310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHW33_RS10330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
JHW33_RS10340	COG2814	Major facilitator Superfamily
JHW33_RS10350	COG3416	Protein conserved in bacteria
JHW33_RS10360	COG1505	serine-type exopeptidase activity
JHW33_RS10365	COG0248	Ppx GppA phosphatase
JHW33_RS10365	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHW33_RS10385	COG3706	GGDEF domain
JHW33_RS10400	COG2814	Major facilitator Superfamily
JHW33_RS10460	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JHW33_RS10465	COG2501	S4 domain
JHW33_RS10470	COG5342	invasion associated locus B
JHW33_RS10480	COG0494	nUDIX hydrolase
JHW33_RS10490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS10495	COG1393	Belongs to the ArsC family
JHW33_RS10500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW33_RS10505	COG1876	peptidase activity
JHW33_RS10520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
JHW33_RS10525	COG0400	carboxylic ester hydrolase activity
JHW33_RS10535	COG2707	UPF0756 membrane protein
JHW33_RS10540	COG2321	neutral zinc metallopeptidase
JHW33_RS10545	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JHW33_RS10550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
JHW33_RS10555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS10560	COG2716	regulation of RNA biosynthetic process
JHW33_RS10565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JHW33_RS10570	COG0628	permease
JHW33_RS10575	COG4783	chaperone-mediated protein folding
JHW33_RS10580	COG1393	Belongs to the ArsC family
JHW33_RS10585	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHW33_RS10590	COG2233	PERMEase
JHW33_RS10595	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JHW33_RS10605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JHW33_RS10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW33_RS10615	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
JHW33_RS10625	COG2200	EAL domain
JHW33_RS10635	COG2239	Acts as a magnesium transporter
JHW33_RS10640	COG3447	MASE1 domain protein
JHW33_RS10640	COG5002	protein histidine kinase activity
JHW33_RS10640	COG5001	Diguanylate cyclase
JHW33_RS10645	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
JHW33_RS10650	COG0215	cysteine-tRNA ligase activity
JHW33_RS10655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHW33_RS10660	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW33_RS10670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JHW33_RS10675	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JHW33_RS10680	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
JHW33_RS10685	COG4181	ATPase activity
JHW33_RS10690	COG2755	lipolytic protein G-D-S-L family
JHW33_RS10695	COG0300	oxidoreductase activity
JHW33_RS10700	COG3118	belongs to the thioredoxin family
JHW33_RS10705	COG0330	HflC and HflK could
JHW33_RS10710	COG1585	Membrane protein implicated in regulation of membrane protease activity
JHW33_RS10720	COG2217	Heavy metal translocating P-type atpase
JHW33_RS10725	COG3735	TraB family
JHW33_RS10730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JHW33_RS10735	COG2223	nitrite transmembrane transporter activity
JHW33_RS10740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHW33_RS10740	COG4651	solute:proton antiporter activity
JHW33_RS10745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS10750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
JHW33_RS10760	COG0326	Molecular chaperone. Has ATPase activity
JHW33_RS10765	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JHW33_RS10770	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JHW33_RS10780	COG0366	Alpha amylase catalytic
JHW33_RS10785	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JHW33_RS10790	COG2832	Protein of unknown function (DUF454)
JHW33_RS10805	COG3264	Mechanosensitive ion channel
JHW33_RS10805	COG1196	nuclear chromosome segregation
JHW33_RS10810	COG1309	transcriptional regulator
JHW33_RS10815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW33_RS10820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS10830	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHW33_RS10835	COG0803	Belongs to the bacterial solute-binding protein 9 family
JHW33_RS10840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW33_RS10865	COG0583	DNA-binding transcription factor activity
JHW33_RS10870	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JHW33_RS10875	COG2252	PERMEase
JHW33_RS10885	COG3695	enzyme binding
JHW33_RS10890	COG3126	Type III secretion system lipoprotein chaperone (YscW)
JHW33_RS10895	COG1946	Acyl-CoA thioesterase
JHW33_RS10900	COG0004	ammonium transporteR
JHW33_RS10905	COG0347	Belongs to the P(II) protein family
JHW33_RS10910	COG1132	(ABC) transporter
JHW33_RS10915	COG1132	(ABC) transporter
JHW33_RS10920	COG1522	sequence-specific DNA binding
JHW33_RS10930	COG0561	phosphatase activity
JHW33_RS10935	COG4533	DNA binding
JHW33_RS10940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
JHW33_RS10945	COG0824	Thioesterase
JHW33_RS10950	COG1555	photosystem II stabilization
JHW33_RS10955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JHW33_RS10965	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JHW33_RS10970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JHW33_RS10975	COG0740	serine-type endopeptidase activity
JHW33_RS10985	COG0271	Belongs to the BolA IbaG family
JHW33_RS10990	COG3056	Lipoprotein
JHW33_RS10995	COG2223	nitrite transmembrane transporter activity
JHW33_RS11000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
JHW33_RS11005	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
JHW33_RS11010	COG1845	cytochrome c oxidase, subunit III
JHW33_RS11015	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
JHW33_RS11020	COG0109	protoheme IX farnesyltransferase activity
JHW33_RS11025	COG2814	Major facilitator Superfamily
JHW33_RS11030	COG0673	inositol 2-dehydrogenase activity
JHW33_RS11035	COG1666	GTP binding
JHW33_RS11040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHW33_RS11045	COG0693	protein deglycase activity
JHW33_RS11050	COG0301	tRNA thio-modification
JHW33_RS11050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW33_RS11060	COG0142	geranyltranstransferase activity
JHW33_RS11065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JHW33_RS11070	COG0667	Aldo Keto reductase
JHW33_RS11075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JHW33_RS11080	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
JHW33_RS11095	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHW33_RS11095	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
JHW33_RS11100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JHW33_RS11105	COG4238	major outer membrane lipoprotein
JHW33_RS11110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHW33_RS11115	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JHW33_RS11120	COG1862	Preprotein translocase
JHW33_RS11125	COG0343	queuine tRNA-ribosyltransferase activity
JHW33_RS11135	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
JHW33_RS11140	COG0450	alkyl hydroperoxide reductase
JHW33_RS11150	COG1113	amino acid transport
JHW33_RS11160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHW33_RS11175	COG5002	protein histidine kinase activity
JHW33_RS11180	COG0745	RESPONSE REGULATOR receiver
JHW33_RS11185	COG0420	3'-5' exonuclease activity
JHW33_RS11190	COG0419	ATPase involved in DNA repair
JHW33_RS11200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JHW33_RS11205	COG1116	anion transmembrane transporter activity
JHW33_RS11220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS11225	COG1940	carbohydrate kinase activity
JHW33_RS11230	COG2974	May be involved in recombination
JHW33_RS11240	COG4126	flavin adenine dinucleotide binding
JHW33_RS11255	COG1414	Transcriptional regulator
JHW33_RS11260	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHW33_RS11275	COG2354	Protein conserved in bacteria
JHW33_RS11280	COG2226	methyltransferase
JHW33_RS11295	COG2897	thiosulfate sulfurtransferase activity
JHW33_RS11330	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
JHW33_RS11340	COG0560	Phosphoserine phosphatase
JHW33_RS11345	COG1263	PTS System
JHW33_RS11345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS11350	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JHW33_RS11355	COG1737	Transcriptional regulator
JHW33_RS11360	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JHW33_RS11370	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
JHW33_RS11375	COG1381	Involved in DNA repair and RecF pathway recombination
JHW33_RS11380	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JHW33_RS11385	COG0571	ribonuclease III activity
JHW33_RS11395	COG0481	GTPase activity
JHW33_RS11405	COG3086	response to oxidative stress
JHW33_RS11425	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
JHW33_RS11435	COG0513	Belongs to the DEAD box helicase family
JHW33_RS11440	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
JHW33_RS11445	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JHW33_RS11450	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JHW33_RS11455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JHW33_RS11460	COG0497	DNA recombination
JHW33_RS11470	COG2914	Belongs to the UPF0125 (RnfH) family
JHW33_RS11475	COG2867	negative regulation of translational initiation
JHW33_RS11480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JHW33_RS11500	COG0640	Transcriptional regulator
JHW33_RS11505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW33_RS11520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS11525	COG1349	DNA-binding transcription factor activity
JHW33_RS11535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS11540	COG3414	Phosphotransferase system galactitol-specific IIB component
JHW33_RS11545	COG3775	system Galactitol-specific IIC component
JHW33_RS11550	COG1063	alcohol dehydrogenase
JHW33_RS11570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHW33_RS11570	COG2169	Transcriptional regulator
JHW33_RS11580	COG1396	sequence-specific DNA binding
JHW33_RS11595	COG1473	amidohydrolase
JHW33_RS11600	COG0583	DNA-binding transcription factor activity
JHW33_RS11605	COG0384	phenazine biosynthesis protein PhzF
JHW33_RS11615	COG1272	protein, Hemolysin III
JHW33_RS11630	COG3842	ATPase activity
JHW33_RS11635	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JHW33_RS11640	COG0395	ABC-type sugar transport system, permease component
JHW33_RS11645	COG1175	transmembrane transport
JHW33_RS11680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS11685	COG1940	carbohydrate kinase activity
JHW33_RS11690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHW33_RS11695	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS11700	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS11705	COG1129	ABC transporter
JHW33_RS11715	COG1349	DNA-binding transcription factor activity
JHW33_RS11720	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS11725	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW33_RS11725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
JHW33_RS11730	COG0509	glycine decarboxylation via glycine cleavage system
JHW33_RS11735	COG0404	The glycine cleavage system catalyzes the degradation of glycine
JHW33_RS11740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW33_RS11745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
JHW33_RS11750	COG0006	proline dipeptidase activity
JHW33_RS11755	COG3079	Belongs to the UPF0149 family
JHW33_RS11760	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
JHW33_RS11770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JHW33_RS11780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
JHW33_RS11785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JHW33_RS11790	COG0583	DNA-binding transcription factor activity
JHW33_RS11795	COG0583	DNA-binding transcription factor activity
JHW33_RS11800	COG4221	oxidoreductase activity
JHW33_RS11810	COG1279	arginine transmembrane transporter activity
JHW33_RS11815	COG0668	transmembrane transport
JHW33_RS11820	COG2223	nitrite transmembrane transporter activity
JHW33_RS11825	COG3250	beta-galactosidase activity
JHW33_RS11830	COG1609	Transcriptional regulator
JHW33_RS11835	COG0191	fructose-bisphosphate aldolase activity
JHW33_RS11840	COG0126	phosphoglycerate kinase activity
JHW33_RS11845	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
JHW33_RS11850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHW33_RS11855	COG0501	Belongs to the peptidase M48B family
JHW33_RS11865	COG3121	Chaperone
JHW33_RS11870	COG3188	usher protein
JHW33_RS11885	COG3539	Fimbrial protein
JHW33_RS11895	COG1166	arginine decarboxylase activity
JHW33_RS11900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JHW33_RS11935	COG2814	Major facilitator Superfamily
JHW33_RS11940	COG3091	SprT-like family
JHW33_RS11945	COG2356	endonuclease I
JHW33_RS11950	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JHW33_RS11955	COG0189	ligase activity
JHW33_RS11960	COG1678	Uncharacterized ACR, COG1678
JHW33_RS11965	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JHW33_RS11970	COG2805	Type II/IV secretion system protein
JHW33_RS11975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JHW33_RS11980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHW33_RS11985	COG0762	integral membrane protein
JHW33_RS11990	COG1872	DUF167
JHW33_RS11995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JHW33_RS12000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHW33_RS12010	COG2066	Belongs to the glutaminase family
JHW33_RS12015	COG3171	Protein conserved in bacteria
JHW33_RS12020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JHW33_RS12025	COG1194	a g-specific adenine glycosylase
JHW33_RS12035	COG0741	lytic transglycosylase activity
JHW33_RS12050	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS12060	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS12070	COG2244	polysaccharide biosynthetic process
JHW33_RS12075	COG3206	protein involved in exopolysaccharide biosynthesis
JHW33_RS12075	COG0489	protein tyrosine kinase activity
JHW33_RS12090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHW33_RS12095	COG1982	Orn Lys Arg decarboxylase major
JHW33_RS12105	COG2271	Major facilitator Superfamily
JHW33_RS12110	COG2731	YhcH YjgK YiaL family protein
JHW33_RS12115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS12120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS12125	COG3568	Endonuclease Exonuclease Phosphatase
JHW33_RS12130	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW33_RS12135	COG0392	lysyltransferase activity
JHW33_RS12140	COG1914	H( )-stimulated, divalent metal cation uptake system
JHW33_RS12145	COG0840	transmembrane signaling receptor activity
JHW33_RS12155	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
JHW33_RS12200	COG1088	dTDP-glucose 4,6-dehydratase activity
JHW33_RS12230	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS12260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JHW33_RS12270	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS12295	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JHW33_RS12305	COG0531	amino acid
JHW33_RS12330	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS12335	COG0765	amino acid transport
JHW33_RS12355	COG0583	DNA-binding transcription factor activity
JHW33_RS12375	COG0583	DNA-binding transcription factor activity
JHW33_RS12380	COG0477	Major facilitator Superfamily
JHW33_RS12425	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW33_RS12430	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS12435	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS12440	COG2271	Major facilitator Superfamily
JHW33_RS12445	COG3835	regulator
JHW33_RS12450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHW33_RS12455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
JHW33_RS12460	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JHW33_RS12465	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHW33_RS12475	COG0316	Belongs to the HesB IscA family
JHW33_RS12485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
JHW33_RS12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW33_RS12495	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHW33_RS12500	COG1120	ATPase activity
JHW33_RS12505	COG4774	siderophore transport
JHW33_RS12510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHW33_RS12515	COG1643	Atp-dependent helicase
JHW33_RS12520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
JHW33_RS12525	COG1489	DNA binding
JHW33_RS12540	COG0617	tRNA 3'-terminal CCA addition
JHW33_RS12545	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
JHW33_RS12550	COG0642	Histidine kinase
JHW33_RS12565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JHW33_RS12570	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JHW33_RS12575	COG0842	Transport permease protein
JHW33_RS12580	COG1131	(ABC) transporter
JHW33_RS12585	COG0288	reversible hydration of carbon dioxide
JHW33_RS12595	COG1349	DNA-binding transcription factor activity
JHW33_RS12600	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS12605	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS12620	COG3730	PTS system glucitol sorbitol-specific
JHW33_RS12625	COG2132	Multicopper oxidase
JHW33_RS12635	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
JHW33_RS12640	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
JHW33_RS12650	COG0697	spore germination
JHW33_RS12655	COG3112	Uncharacterised protein family (UPF0231)
JHW33_RS12675	COG3121	Chaperone
JHW33_RS12695	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW33_RS12705	COG0584	glycerophosphoryl diester phosphodiesterase
JHW33_RS12710	COG1940	carbohydrate kinase activity
JHW33_RS12720	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW33_RS12725	COG0508	dehydrogenase complex catalyzes the overall conversion of
JHW33_RS12730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
JHW33_RS12735	COG2186	Transcriptional regulator
JHW33_RS12740	COG1113	amino acid transport
JHW33_RS12745	COG2211	Major facilitator Superfamily
JHW33_RS12750	COG3940	Belongs to the glycosyl hydrolase 43 family
JHW33_RS12755	COG3725	Membrane protein required for beta-lactamase induction
JHW33_RS12765	COG0157	Belongs to the NadC ModD family
JHW33_RS12770	COG4969	Belongs to the N-Me-Phe pilin family
JHW33_RS12775	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHW33_RS12785	COG0516	GMP reductase activity
JHW33_RS12795	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
JHW33_RS12800	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
JHW33_RS12805	COG0494	nUDIX hydrolase
JHW33_RS12830	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JHW33_RS12835	COG0849	cell division
JHW33_RS12840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
JHW33_RS12850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHW33_RS12855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JHW33_RS12860	COG0772	Belongs to the SEDS family
JHW33_RS12870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHW33_RS12875	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JHW33_RS12880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JHW33_RS12885	COG0768	penicillin binding
JHW33_RS12890	COG3116	cell division
JHW33_RS12895	COG0275	rRNA processing
JHW33_RS12900	COG2001	Belongs to the MraZ family
JHW33_RS12905	COG1609	Transcriptional regulator
JHW33_RS12915	COG0028	Belongs to the TPP enzyme family
JHW33_RS12920	COG1022	Amp-dependent synthetase and ligase
JHW33_RS12935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
JHW33_RS12940	COG0473	3-isopropylmalate dehydrogenase activity
JHW33_RS12945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
JHW33_RS12950	COG0066	3-isopropylmalate dehydratase activity
JHW33_RS12960	COG2814	Major facilitator Superfamily
JHW33_RS12975	COG4143	(ABC) transporter
JHW33_RS12980	COG1178	ABC-type Fe3 transport system permease component
JHW33_RS12990	COG0586	Pfam SNARE associated Golgi protein
JHW33_RS12995	COG0417	DNA replication proofreading
JHW33_RS13000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
JHW33_RS13005	COG0564	pseudouridine synthase activity
JHW33_RS13015	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
JHW33_RS13020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
JHW33_RS13035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JHW33_RS13040	COG2967	ApaG domain
JHW33_RS13045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JHW33_RS13050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JHW33_RS13060	COG2966	Psort location CytoplasmicMembrane, score
JHW33_RS13065	COG1280	lysine exporter protein (LysE YggA)
JHW33_RS13070	COG0475	glutathione-regulated potassium exporter activity
JHW33_RS13070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
JHW33_RS13085	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JHW33_RS13095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JHW33_RS13110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JHW33_RS13115	COG1047	Peptidyl-prolyl cis-trans
JHW33_RS13120	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JHW33_RS13130	COG0196	riboflavin kinase activity
JHW33_RS13140	COG0583	DNA-binding transcription factor activity
JHW33_RS13145	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
JHW33_RS13155	COG0443	Heat shock 70 kDa protein
JHW33_RS13160	COG1584	GPR1 FUN34 yaaH family protein
JHW33_RS13170	COG0521	Mo-molybdopterin cofactor biosynthetic process
JHW33_RS13175	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHW33_RS13180	COG1115	amino acid carrier protein
JHW33_RS13185	COG3022	response to hydroperoxide
JHW33_RS13210	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JHW33_RS13215	COG0745	RESPONSE REGULATOR receiver
JHW33_RS13220	COG3045	CreA protein
JHW33_RS13225	COG3708	Transcriptional regulator
JHW33_RS13225	COG2207	Transcriptional regulator
JHW33_RS13230	COG0406	alpha-ribazole phosphatase activity
JHW33_RS13235	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
JHW33_RS13240	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
JHW33_RS13245	COG0741	lytic transglycosylase activity
JHW33_RS13250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JHW33_RS13260	COG0488	(ABC) transporter
JHW33_RS13270	COG0604	alcohol dehydrogenase
JHW33_RS13280	COG3064	Membrane
JHW33_RS13295	COG0560	Phosphoserine phosphatase
JHW33_RS13300	COG3726	membrane protein affecting hemolysin expression
JHW33_RS13305	COG3550	peptidyl-serine autophosphorylation
JHW33_RS13320	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JHW33_RS13325	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JHW33_RS13330	COG0084	hydrolase, TatD family'
JHW33_RS13335	COG4667	esterase of the alpha-beta hydrolase superfamily
JHW33_RS13345	COG2823	Periplasmic or secreted lipoprotein
JHW33_RS13350	COG3979	chitinase
JHW33_RS13355	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JHW33_RS13360	COG3550	peptidyl-serine autophosphorylation
JHW33_RS13375	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
JHW33_RS13380	COG2813	Specifically methylates the guanine in position
JHW33_RS13385	COG0667	Aldo Keto reductase
JHW33_RS13390	COG0583	DNA-binding transcription factor activity
JHW33_RS13425	COG1917	Cupin 2, conserved barrel domain protein
JHW33_RS13425	COG4977	sequence-specific DNA binding
JHW33_RS13430	COG1917	Cupin 2, conserved barrel domain protein
JHW33_RS13430	COG2169	Transcriptional regulator
JHW33_RS13435	COG1070	Carbohydrate kinase
JHW33_RS13445	COG0235	Class ii aldolase
JHW33_RS13450	COG1454	alcohol dehydrogenase
JHW33_RS13475	COG1760	l-serine dehydratase
JHW33_RS13480	COG0814	amino acid
JHW33_RS13490	COG2199	diguanylate cyclase activity
JHW33_RS13495	COG2885	chlorophyll binding
JHW33_RS13545	COG3385	transposase activity
JHW33_RS13565	COG2003	Belongs to the UPF0758 family
JHW33_RS13620	COG1216	Glycosyl transferase, family 2
JHW33_RS13630	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
JHW33_RS13635	COG0732	type I restriction modification DNA specificity domain
JHW33_RS13655	COG0582	viral genome integration into host DNA
JHW33_RS13665	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JHW33_RS13670	COG0795	lipopolysaccharide-transporting ATPase activity
JHW33_RS13675	COG0795	lipopolysaccharide-transporting ATPase activity
JHW33_RS13680	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHW33_RS13685	COG2927	DNA polymerase III (CHI subunit)
JHW33_RS13695	COG0583	DNA-binding transcription factor activity
JHW33_RS13700	COG2801	Transposase and inactivated derivatives
JHW33_RS13720	COG3121	Chaperone
JHW33_RS13725	COG3188	usher protein
JHW33_RS13755	COG1263	PTS System
JHW33_RS13755	COG2190	(PTS) system
JHW33_RS13755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS13760	COG2723	6-phospho-beta-galactosidase activity
JHW33_RS13770	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JHW33_RS13775	COG0366	Alpha amylase catalytic
JHW33_RS13780	COG2731	YhcH YjgK YiaL family protein
JHW33_RS13790	COG0549	Belongs to the carbamate kinase family
JHW33_RS13800	COG1288	antiporter activity
JHW33_RS13805	COG1438	arginine binding
JHW33_RS13810	COG0540	Belongs to the ATCase OTCase family
JHW33_RS13850	COG2308	Evidence 4 Homologs of previously reported genes of
JHW33_RS13860	COG1305	Transglutaminase-like
JHW33_RS13870	COG1609	Transcriptional regulator
JHW33_RS13880	COG3842	ATPase activity
JHW33_RS13885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW33_RS13890	COG1554	hydrolase, family 65, central catalytic
JHW33_RS13895	COG0673	inositol 2-dehydrogenase activity
JHW33_RS13900	COG1082	Xylose isomerase domain protein TIM barrel
JHW33_RS13905	COG1063	alcohol dehydrogenase
JHW33_RS13910	COG0395	ABC-type sugar transport system, permease component
JHW33_RS13915	COG1175	transmembrane transport
JHW33_RS13920	COG1653	transport
JHW33_RS13925	COG0366	Alpha amylase catalytic
JHW33_RS13935	COG2721	sulfolactate sulfo-lyase activity
JHW33_RS13940	COG0246	Mannitol dehydrogenase
JHW33_RS13945	COG1904	glucuronate isomerase
JHW33_RS13950	COG2271	Major facilitator Superfamily
JHW33_RS13960	COG0586	Pfam SNARE associated Golgi protein
JHW33_RS13970	COG1422	Protein of unknown function (DUF1090)
JHW33_RS13975	COG4575	ribosome binding
JHW33_RS13980	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
JHW33_RS13990	COG2259	Doxx family
JHW33_RS13995	COG0435	Glutathione S-transferase
JHW33_RS14000	COG0583	DNA-binding transcription factor activity
JHW33_RS14005	COG1741	Belongs to the pirin family
JHW33_RS14010	COG2165	general secretion pathway protein
JHW33_RS14025	COG4796	Type ii and iii secretion system protein
JHW33_RS14045	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHW33_RS14050	COG1459	type II secretion system
JHW33_RS14065	COG0739	heme binding
JHW33_RS14075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JHW33_RS14080	COG3107	peptidoglycan biosynthetic process
JHW33_RS14085	COG0792	nuclease activity
JHW33_RS14090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHW33_RS14095	COG2823	Periplasmic or secreted lipoprotein
JHW33_RS14100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JHW33_RS14105	COG0784	Response regulator, receiver
JHW33_RS14105	COG2198	Histidine kinase
JHW33_RS14105	COG5002	protein histidine kinase activity
JHW33_RS14110	COG0070	glutamate synthase
JHW33_RS14110	COG0069	glutamate synthase activity
JHW33_RS14110	COG0067	glutamate synthase
JHW33_RS14115	COG0493	'glutamate synthase
JHW33_RS14120	COG2969	positive regulation of protein catabolic process
JHW33_RS14125	COG0625	glutathione transferase activity
JHW33_RS14130	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JHW33_RS14135	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JHW33_RS14140	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
JHW33_RS14145	COG3105	Protein conserved in bacteria
JHW33_RS14150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHW33_RS14155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JHW33_RS14160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JHW33_RS14165	COG5007	Belongs to the BolA IbaG family
JHW33_RS14170	COG3113	response to antibiotic
JHW33_RS14175	COG2854	intermembrane phospholipid transfer
JHW33_RS14180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
JHW33_RS14185	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
JHW33_RS14190	COG1127	ABC transporter
JHW33_RS14195	COG0530	calcium, potassium:sodium antiporter activity
JHW33_RS14200	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JHW33_RS14200	COG0517	IMP dehydrogenase activity
JHW33_RS14205	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
JHW33_RS14210	COG3117	lipopolysaccharide transmembrane transporter activity
JHW33_RS14215	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
JHW33_RS14220	COG1137	ATPase activity
JHW33_RS14225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JHW33_RS14240	COG1660	Displays ATPase and GTPase activities
JHW33_RS14245	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS14250	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS14250	COG3711	transcriptional antiterminator
JHW33_RS14265	COG3964	amidohydrolase
JHW33_RS14295	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW33_RS14305	COG3783	Cytochrome b(562)
JHW33_RS14310	COG0312	modulator of DNA gyrase
JHW33_RS14315	COG3028	Belongs to the UPF0307 family
JHW33_RS14320	COG2732	(Barnase) inhibitor
JHW33_RS14325	COG4290	ribonuclease
JHW33_RS14330	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS14335	COG0531	amino acid
JHW33_RS14340	COG0110	maltose O-acetyltransferase activity
JHW33_RS14345	COG1289	transmembrane transporter activity
JHW33_RS14350	COG1566	PFAM secretion protein HlyD family protein
JHW33_RS14360	COG0583	DNA-binding transcription factor activity
JHW33_RS14365	COG0312	modulator of DNA gyrase
JHW33_RS14370	COG3164	Protein of unknown function
JHW33_RS14375	COG1530	ribonuclease E activity
JHW33_RS14385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
JHW33_RS14390	COG1792	Involved in formation and maintenance of cell shape
JHW33_RS14395	COG1077	Cell shape determining protein MreB Mrl
JHW33_RS14400	COG2200	EAL domain
JHW33_RS14400	COG2199	diguanylate cyclase activity
JHW33_RS14405	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JHW33_RS14410	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
JHW33_RS14415	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JHW33_RS14420	COG0511	ligase activity, forming carbon-carbon bonds
JHW33_RS14425	COG0439	Biotin carboxylase
JHW33_RS14430	COG3924	membrane
JHW33_RS14435	COG4145	pantothenate transmembrane transporter activity
JHW33_RS14440	COG2264	protein methyltransferase activity
JHW33_RS14465	COG1560	Kdo2-lipid A biosynthetic process
JHW33_RS14475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JHW33_RS14480	COG4597	amino acid ABC transporter
JHW33_RS14485	COG0765	amino acid transport
JHW33_RS14490	COG1126	abc transporter atp-binding protein
JHW33_RS14500	COG1380	Effector of murein hydrolase LrgA
JHW33_RS14505	COG0583	DNA-binding transcription factor activity
JHW33_RS14510	COG0025	NhaP-type Na H and K H
JHW33_RS14515	COG2252	PERMEase
JHW33_RS14520	COG0625	glutathione transferase activity
JHW33_RS14530	COG0840	transmembrane signaling receptor activity
JHW33_RS14535	COG0483	inositol monophosphate 1-phosphatase activity
JHW33_RS14540	COG1280	lysine exporter protein (LysE YggA)
JHW33_RS14545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHW33_RS14565	COG0625	glutathione transferase activity
JHW33_RS14570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW33_RS14600	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS14605	COG0583	DNA-binding transcription factor activity
JHW33_RS14640	COG0583	DNA-binding transcription factor activity
JHW33_RS14645	COG0402	S-adenosylhomocysteine deaminase activity
JHW33_RS14655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JHW33_RS14670	COG2382	esterase
JHW33_RS14675	COG0583	DNA-binding transcription factor activity
JHW33_RS14680	COG0625	glutathione transferase activity
JHW33_RS14690	COG2315	Protein conserved in bacteria
JHW33_RS14705	COG1501	Belongs to the glycosyl hydrolase 31 family
JHW33_RS14715	COG3684	Belongs to the aldolase LacD family
JHW33_RS14725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS14730	COG1349	DNA-binding transcription factor activity
JHW33_RS14735	COG1448	Aminotransferase
JHW33_RS14740	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS14750	COG1522	sequence-specific DNA binding
JHW33_RS14770	COG0604	alcohol dehydrogenase
JHW33_RS14780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JHW33_RS14785	COG0735	belongs to the Fur family
JHW33_RS14790	COG3237	CsbD-like
JHW33_RS14795	COG0534	Mate efflux family protein
JHW33_RS14800	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHW33_RS14805	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JHW33_RS14810	COG2937	Belongs to the GPAT DAPAT family
JHW33_RS14815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
JHW33_RS14820	COG3161	chorismate lyase activity
JHW33_RS14825	COG3223	Belongs to the PsiE family
JHW33_RS14830	COG0166	Belongs to the GPI family
JHW33_RS14835	COG0527	aspartate kinase activity
JHW33_RS14845	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHW33_RS14855	COG3842	ATPase activity
JHW33_RS14865	COG0395	ABC-type sugar transport system, permease component
JHW33_RS14895	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
JHW33_RS14905	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
JHW33_RS14910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
JHW33_RS14940	COG0151	Belongs to the GarS family
JHW33_RS14960	COG1515	deoxyribonuclease V activity
JHW33_RS14965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
JHW33_RS14975	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
JHW33_RS14980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
JHW33_RS14985	COG0352	thiamine-phosphate diphosphorylase activity
JHW33_RS14990	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
JHW33_RS14995	COG2104	thiamine diphosphate biosynthetic process
JHW33_RS15000	COG2022	thiamine diphosphate biosynthetic process
JHW33_RS15010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JHW33_RS15015	COG0085	RNA polymerase activity
JHW33_RS15020	COG0222	ribosome binding
JHW33_RS15025	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JHW33_RS15035	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JHW33_RS15040	COG0250	Participates in transcription elongation, termination and antitermination
JHW33_RS15050	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHW33_RS15080	COG1072	(Pantothenic acid kinase))
JHW33_RS15085	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JHW33_RS15085	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JHW33_RS15090	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JHW33_RS15125	COG1739	Uncharacterized protein family UPF0029
JHW33_RS15130	COG0006	proline dipeptidase activity
JHW33_RS15135	COG1024	Enoyl-CoA hydratase
JHW33_RS15135	COG1250	3-hydroxyacyl-CoA dehydrogenase
JHW33_RS15140	COG0183	Belongs to the thiolase family
JHW33_RS15150	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHW33_RS15165	COG0084	hydrolase, TatD family'
JHW33_RS15170	COG0805	protein transport
JHW33_RS15185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
JHW33_RS15190	COG3165	ubiquinone biosynthetic process from chorismate
JHW33_RS15200	COG1322	Protein conserved in bacteria
JHW33_RS15205	COG0586	Pfam SNARE associated Golgi protein
JHW33_RS15215	COG0753	catalase activity
JHW33_RS15220	COG0412	Dienelactone hydrolase
JHW33_RS15225	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHW33_RS15230	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS15230	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW33_RS15230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS15235	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS15240	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS15245	COG1882	Formate acetyltransferase
JHW33_RS15250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JHW33_RS15255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS15260	COG2207	Transcriptional regulator
JHW33_RS15280	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JHW33_RS15285	COG0583	DNA-binding transcription factor activity
JHW33_RS15305	COG0584	glycerophosphoryl diester phosphodiesterase
JHW33_RS15315	COG0395	ABC-type sugar transport system, permease component
JHW33_RS15320	COG1175	transmembrane transport
JHW33_RS15325	COG1653	transport
JHW33_RS15345	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS15350	COG0410	ABC transporter
JHW33_RS15385	COG2177	Part of the ABC transporter FtsEX involved in
JHW33_RS15390	COG2884	Cell division ATP-binding protein ftsE
JHW33_RS15395	COG0552	protein localization to endoplasmic reticulum
JHW33_RS15400	COG0742	ribosomal rna small subunit methyltransferase
JHW33_RS15405	COG3776	membrane
JHW33_RS15410	COG3714	YhhN family
JHW33_RS15425	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
JHW33_RS15435	COG2271	Major facilitator Superfamily
JHW33_RS15440	COG3842	ATPase activity
JHW33_RS15450	COG1609	Transcriptional regulator
JHW33_RS15460	COG1175	transmembrane transport
JHW33_RS15465	COG0395	ABC-type sugar transport system, permease component
JHW33_RS15470	COG0366	Alpha amylase catalytic
JHW33_RS15475	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
JHW33_RS15515	COG0561	phosphatase activity
JHW33_RS15520	COG2267	carboxylic ester hydrolase activity
JHW33_RS15525	COG1280	lysine exporter protein (LysE YggA)
JHW33_RS15530	COG1280	lysine exporter protein (LysE YggA)
JHW33_RS15535	COG0514	ATP-dependent DNA helicase (RecQ)
JHW33_RS15540	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
JHW33_RS15545	COG2050	protein possibly involved in aromatic compounds catabolism
JHW33_RS15550	COG2962	Rard protein
JHW33_RS15555	COG3180	Ammonia monooxygenase
JHW33_RS15570	COG0210	DNA helicase
JHW33_RS15575	COG1011	Hydrolase
JHW33_RS15590	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JHW33_RS15595	COG5567	small periplasmic lipoprotein
JHW33_RS15600	COG3072	Adenylate cyclase
JHW33_RS15605	COG0181	hydroxymethylbilane synthase activity
JHW33_RS15610	COG1587	Uroporphyrinogen-III synthase
JHW33_RS15615	COG2959	enzyme of heme biosynthesis
JHW33_RS15620	COG3071	HemY protein
JHW33_RS15650	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
JHW33_RS15660	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JHW33_RS15665	COG2244	polysaccharide biosynthetic process
JHW33_RS15670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JHW33_RS15675	COG0456	acetyltransferase
JHW33_RS15680	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
JHW33_RS15685	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JHW33_RS15690	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
JHW33_RS15695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JHW33_RS15700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JHW33_RS15705	COG3118	belongs to the thioredoxin family
JHW33_RS15715	COG0248	Ppx GppA phosphatase
JHW33_RS15730	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
JHW33_RS15735	COG0583	DNA-binding transcription factor activity
JHW33_RS15745	COG0129	dihydroxy-acid dehydratase activity
JHW33_RS15755	COG3978	acetolactate synthase activity
JHW33_RS15770	COG2814	Major facilitator Superfamily
JHW33_RS15775	COG0606	chelatase, subunit chli
JHW33_RS15780	COG3085	chromosome segregation
JHW33_RS15785	COG0583	DNA-binding transcription factor activity
JHW33_RS15790	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS15795	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS15800	COG1129	ABC transporter
JHW33_RS15805	COG1879	ABC-type sugar transport system periplasmic component
JHW33_RS15845	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JHW33_RS15855	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW33_RS15860	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JHW33_RS15880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW33_RS15890	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHW33_RS15890	COG0678	peroxiredoxin activity
JHW33_RS15900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
JHW33_RS15905	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
JHW33_RS15910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW33_RS15925	COG0527	aspartate kinase activity
JHW33_RS15925	COG0460	homoserine dehydrogenase
JHW33_RS15930	COG0626	cystathionine gamma-synthase activity
JHW33_RS15935	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
JHW33_RS15940	COG0254	rRNA binding
JHW33_RS15945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JHW33_RS15950	COG1609	Transcriptional regulator
JHW33_RS15955	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
JHW33_RS15960	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JHW33_RS15965	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JHW33_RS15970	COG1575	Belongs to the MenA family. Type 1 subfamily
JHW33_RS15975	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
JHW33_RS15980	COG3074	FtsZ-dependent cytokinesis
JHW33_RS15985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JHW33_RS15995	COG1494	fructose-1,6-bisphosphatase
JHW33_RS16000	COG2814	Major facilitator Superfamily
JHW33_RS16010	COG3152	Membrane
JHW33_RS16020	COG0149	triose-phosphate isomerase activity
JHW33_RS16035	COG3678	ATP-independent chaperone mediated protein folding
JHW33_RS16040	COG0745	RESPONSE REGULATOR receiver
JHW33_RS16045	COG2205	protein histidine kinase activity
JHW33_RS16050	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JHW33_RS16055	COG1045	serine acetyltransferase
JHW33_RS16060	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JHW33_RS16065	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
JHW33_RS16070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHW33_RS16075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW33_RS16080	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
JHW33_RS16085	COG4942	peptidase
JHW33_RS16090	COG2861	carbohydrate metabolic process
JHW33_RS16095	COG0438	transferase activity, transferring glycosyl groups
JHW33_RS16110	COG0156	8-amino-7-oxononanoate synthase activity
JHW33_RS16115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JHW33_RS16125	COG0859	PFAM glycosyl transferase family 9
JHW33_RS16135	COG1442	glycosyl transferase family 8
JHW33_RS16145	COG1216	Glycosyl transferase, family 2
JHW33_RS16150	COG0859	PFAM glycosyl transferase family 9
JHW33_RS16160	COG1519	Transferase
JHW33_RS16175	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JHW33_RS16180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JHW33_RS16185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JHW33_RS16190	COG2003	Belongs to the UPF0758 family
JHW33_RS16195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JHW33_RS16200	COG0756	dUTP diphosphatase activity
JHW33_RS16205	COG1309	transcriptional regulator
JHW33_RS16210	COG3385	transposase activity
JHW33_RS16225	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
JHW33_RS16230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JHW33_RS16235	COG1561	YicC-like family, N-terminal region
JHW33_RS16240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW33_RS16250	COG2860	membrane
JHW33_RS16265	COG1758	RNA polymerase activity
JHW33_RS16270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHW33_RS16275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHW33_RS16280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JHW33_RS16285	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS16290	COG0786	glutamate:sodium symporter activity
JHW33_RS16295	COG2233	PERMEase
JHW33_RS16300	COG2982	Protein involved in outer membrane biogenesis
JHW33_RS16305	COG0456	acetyltransferase
JHW33_RS16310	COG1490	D-aminoacyl-tRNA deacylase activity
JHW33_RS16315	COG1295	ribonuclease BN
JHW33_RS16320	COG1011	Hydrolase
JHW33_RS16330	COG0174	glutamine synthetase
JHW33_RS16335	COG3852	Histidine kinase
JHW33_RS16345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JHW33_RS16355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JHW33_RS16360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHW33_RS16360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHW33_RS16365	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHW33_RS16370	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
JHW33_RS16375	COG3084	Protein conserved in bacteria
JHW33_RS16380	COG0746	molybdenum cofactor guanylyltransferase activity
JHW33_RS16385	COG1763	Mo-molybdopterin cofactor biosynthetic process
JHW33_RS16410	COG2186	Transcriptional regulator
JHW33_RS16415	COG1609	Transcriptional regulator
JHW33_RS16420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS16425	COG1879	ABC-type sugar transport system periplasmic component
JHW33_RS16430	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS16435	COG1129	ABC transporter
JHW33_RS16440	COG1869	D-ribose catabolic process
JHW33_RS16445	COG3158	transport of potassium into the cell
JHW33_RS16455	COG2425	protein containing a von Willebrand factor type A (vWA) domain
JHW33_RS16460	COG1522	sequence-specific DNA binding
JHW33_RS16465	COG0716	FMN binding
JHW33_RS16470	COG0445	tRNA wobble uridine modification
JHW33_RS16475	COG0357	Ribosomal RNA small subunit methyltransferase G
JHW33_RS16480	COG3312	ion transport
JHW33_RS16500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JHW33_RS16505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JHW33_RS16510	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JHW33_RS16515	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JHW33_RS16520	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JHW33_RS16525	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JHW33_RS16535	COG1187	pseudouridine synthase activity
JHW33_RS16540	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JHW33_RS16545	COG0573	inorganic phosphate transmembrane transporter activity
JHW33_RS16550	COG0581	inorganic phosphate transmembrane transporter activity
JHW33_RS16560	COG0704	Plays a role in the regulation of phosphate uptake
JHW33_RS16570	COG1082	Xylose isomerase domain protein TIM barrel
JHW33_RS16570	COG3185	4-Hydroxyphenylpyruvate dioxygenase
JHW33_RS16575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW33_RS16580	COG2252	PERMEase
JHW33_RS16585	COG0431	NADPH-dependent FMN reductase
JHW33_RS16590	COG2091	lysine biosynthetic process via aminoadipic acid
JHW33_RS16595	COG0840	transmembrane signaling receptor activity
JHW33_RS16600	COG0583	DNA-binding transcription factor activity
JHW33_RS16610	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JHW33_RS16615	COG0706	membrane insertase activity
JHW33_RS16625	COG0594	ribonuclease P activity
JHW33_RS16630	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JHW33_RS16635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JHW33_RS16640	COG0592	DNA-directed DNA polymerase activity
JHW33_RS16645	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JHW33_RS16655	COG0561	phosphatase activity
JHW33_RS16660	COG0823	Involved in the tonB-independent uptake of proteins
JHW33_RS16665	COG5645	(Lipo)protein
JHW33_RS16675	COG0071	Belongs to the small heat shock protein (HSP20) family
JHW33_RS16685	COG3977	Valine--pyruvate aminotransferase
JHW33_RS16695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JHW33_RS16700	COG2271	Major facilitator Superfamily
JHW33_RS16710	COG1609	Transcriptional regulator
JHW33_RS16715	COG2211	Major facilitator Superfamily
JHW33_RS16730	COG2885	chlorophyll binding
JHW33_RS16740	COG2818	Glycosylase
JHW33_RS16755	COG2026	Addiction module toxin, RelE StbE family
JHW33_RS16760	COG0752	glycyl-tRNA synthetase alpha subunit
JHW33_RS16765	COG0751	glycine-tRNA ligase activity
JHW33_RS16785	COG2131	deaminase
JHW33_RS16790	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS16790	COG2213	PTS system mannitol-specific
JHW33_RS16795	COG0246	Mannitol dehydrogenase
JHW33_RS16800	COG3722	fumarate hydratase activity
JHW33_RS16810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JHW33_RS16825	COG2258	MOSC domain
JHW33_RS16830	COG0840	transmembrane signaling receptor activity
JHW33_RS16840	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
JHW33_RS16845	COG0243	molybdopterin cofactor binding
JHW33_RS16845	COG3383	formate dehydrogenase (NAD+) activity
JHW33_RS16850	COG0437	4 iron, 4 sulfur cluster binding
JHW33_RS16855	COG2864	formate dehydrogenase
JHW33_RS16865	COG0625	glutathione transferase activity
JHW33_RS16870	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS16880	COG3274	enterobacterial common antigen metabolic process
JHW33_RS16900	COG1063	alcohol dehydrogenase
JHW33_RS16905	COG3135	benzoate transporter
JHW33_RS16910	COG1396	sequence-specific DNA binding
JHW33_RS16930	COG0625	glutathione transferase activity
JHW33_RS16940	COG1280	lysine exporter protein (LysE YggA)
JHW33_RS16950	COG2261	transglycosylase associated protein
JHW33_RS16970	COG1129	ABC transporter
JHW33_RS17010	COG1846	Transcriptional regulator
JHW33_RS17015	COG1764	response to oxidative stress
JHW33_RS17020	COG2194	sulfuric ester hydrolase activity
JHW33_RS17055	COG2079	MmgE PrpD family protein
JHW33_RS17060	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS17065	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS17070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS17075	COG0601	transmembrane transport
JHW33_RS17085	COG1473	amidohydrolase
JHW33_RS17090	COG0583	DNA-binding transcription factor activity
JHW33_RS17100	COG0747	negative chemotaxis
JHW33_RS17105	COG0601	transmembrane transport
JHW33_RS17110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS17115	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS17120	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS17130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
JHW33_RS17140	COG0457	Tetratricopeptide repeat
JHW33_RS17145	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS17150	COG1215	transferase activity, transferring glycosyl groups
JHW33_RS17155	COG0489	protein tyrosine kinase activity
JHW33_RS17165	COG2199	diguanylate cyclase activity
JHW33_RS17165	COG2200	EAL domain
JHW33_RS17170	COG1301	dicarboxylic acid transport
JHW33_RS17175	COG0612	Peptidase, M16
JHW33_RS17180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS17185	COG1942	4-Oxalocrotonate Tautomerase
JHW33_RS17190	COG2200	EAL domain
JHW33_RS17195	COG2982	Protein involved in outer membrane biogenesis
JHW33_RS17200	COG2134	cdp-diacylglycerol pyrophosphatase
JHW33_RS17205	COG0477	Major facilitator Superfamily
JHW33_RS17210	COG1295	ribonuclease BN
JHW33_RS17215	COG0583	DNA-binding transcription factor activity
JHW33_RS17220	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS17230	COG3038	cytochrome b561
JHW33_RS17250	COG0579	oxidoreductase
JHW33_RS17300	COG0579	oxidoreductase
JHW33_RS17305	COG0531	amino acid
JHW33_RS17310	COG2731	YhcH YjgK YiaL family protein
JHW33_RS17315	COG3250	beta-galactosidase activity
JHW33_RS17320	COG1609	Transcriptional regulator
JHW33_RS17330	COG3408	Glycogen debranching enzyme
JHW33_RS17330	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
JHW33_RS17345	COG0339	signal peptide processing
JHW33_RS17350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHW33_RS17350	COG2169	Transcriptional regulator
JHW33_RS17360	COG2814	Major facilitator Superfamily
JHW33_RS17365	COG1309	transcriptional regulator
JHW33_RS17375	COG1132	(ABC) transporter
JHW33_RS17390	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS17395	COG1942	4-Oxalocrotonate Tautomerase
JHW33_RS17405	COG3037	sugar-specific permease SgaT UlaA
JHW33_RS17415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS17425	COG3684	Belongs to the aldolase LacD family
JHW33_RS17430	COG2390	Transcriptional regulator
JHW33_RS17440	COG0545	Peptidyl-prolyl cis-trans isomerase
JHW33_RS17450	COG1335	isochorismatase
JHW33_RS17465	COG0583	DNA-binding transcription factor activity
JHW33_RS17475	COG0322	excinuclease ABC activity
JHW33_RS17480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JHW33_RS17485	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
JHW33_RS17490	COG0339	signal peptide processing
JHW33_RS17495	COG0742	ribosomal rna small subunit methyltransferase
JHW33_RS17500	COG0589	response to stress
JHW33_RS17510	COG0306	phosphate transporter
JHW33_RS17515	COG2081	HI0933 family
JHW33_RS17525	COG0840	transmembrane signaling receptor activity
JHW33_RS17535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JHW33_RS17545	COG0477	Major facilitator Superfamily
JHW33_RS17550	COG1247	-acetyltransferase
JHW33_RS17565	COG1741	Belongs to the pirin family
JHW33_RS17575	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS17585	COG2723	6-phospho-beta-galactosidase activity
JHW33_RS17590	COG1609	Transcriptional regulator
JHW33_RS17595	COG1609	Transcriptional regulator
JHW33_RS17600	COG3265	gluconokinase activity
JHW33_RS17605	COG2610	gluconate transmembrane transporter activity
JHW33_RS17620	COG2095	MarC family integral membrane protein
JHW33_RS17625	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JHW33_RS17630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHW33_RS17635	COG1523	belongs to the glycosyl hydrolase 13 family
JHW33_RS17640	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JHW33_RS17645	COG0297	glycogen (starch) synthase activity
JHW33_RS17650	COG0058	SHG alpha-glucan phosphorylase activity
JHW33_RS17655	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JHW33_RS17660	COG1349	DNA-binding transcription factor activity
JHW33_RS17665	COG0705	Rhomboid family
JHW33_RS17675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JHW33_RS17720	COG0058	SHG alpha-glucan phosphorylase activity
JHW33_RS17725	COG1640	4-alpha-glucanotransferase
JHW33_RS17730	COG0316	Belongs to the HesB IscA family
JHW33_RS17730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JHW33_RS17740	COG2267	carboxylic ester hydrolase activity
JHW33_RS17775	COG0679	Auxin Efflux Carrier
JHW33_RS17785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JHW33_RS17810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JHW33_RS17815	COG1918	ferrous iron import across plasma membrane
JHW33_RS17820	COG2183	response to ionizing radiation
JHW33_RS17825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JHW33_RS17830	COG2373	Large extracellular alpha-helical protein
JHW33_RS17835	COG4953	penicillin-binding protein 1C
JHW33_RS17840	COG3539	Fimbrial protein
JHW33_RS17845	COG3188	usher protein
JHW33_RS17850	COG3121	Chaperone
JHW33_RS17855	COG3539	Fimbrial protein
JHW33_RS17890	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JHW33_RS17895	COG1011	Hydrolase
JHW33_RS17905	COG0494	nUDIX hydrolase
JHW33_RS17910	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
JHW33_RS17930	COG4796	Type ii and iii secretion system protein
JHW33_RS17935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JHW33_RS17940	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JHW33_RS17955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JHW33_RS17960	COG0546	phosphoglycolate phosphatase activity
JHW33_RS17965	COG0180	Tryptophanyl-tRNA synthetase
JHW33_RS17985	COG2146	nitrite reductase [NAD(P)H] activity
JHW33_RS17990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW33_RS17995	COG0402	S-adenosylhomocysteine deaminase activity
JHW33_RS18000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JHW33_RS18005	COG0433	COG0433 Predicted ATPase
JHW33_RS18035	COG1289	transmembrane transporter activity
JHW33_RS18040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JHW33_RS18045	COG1765	OsmC-like protein
JHW33_RS18050	COG3954	Phosphoribulokinase
JHW33_RS18055	COG0583	DNA-binding transcription factor activity
JHW33_RS18070	COG3960	tartronate-semialdehyde synthase activity
JHW33_RS18075	COG3622	Belongs to the hyi family
JHW33_RS18080	COG2084	Dehydrogenase
JHW33_RS18085	COG1953	Uracil, thiamine, allantoin
JHW33_RS18095	COG2233	PERMEase
JHW33_RS18100	COG1929	Belongs to the glycerate kinase type-1 family
JHW33_RS18105	COG3257	ureidoglycine aminohydrolase activity
JHW33_RS18110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JHW33_RS18115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
JHW33_RS18120	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JHW33_RS18125	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
JHW33_RS18140	COG3089	Belongs to the UPF0270 family
JHW33_RS18145	COG0429	hydrolase of the alpha beta-hydrolase fold
JHW33_RS18155	COG0488	(ABC) transporter
JHW33_RS18160	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW33_RS18170	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
JHW33_RS18175	COG1047	Peptidyl-prolyl cis-trans
JHW33_RS18185	COG0545	Peptidyl-prolyl cis-trans isomerase
JHW33_RS18190	COG2964	Protein conserved in bacteria
JHW33_RS18205	COG2168	tRNA wobble position uridine thiolation
JHW33_RS18210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JHW33_RS18215	COG0049	tRNA binding
JHW33_RS18220	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JHW33_RS18225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JHW33_RS18240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JHW33_RS18265	COG2165	general secretion pathway protein
JHW33_RS18270	COG2165	general secretion pathway protein
JHW33_RS18275	COG2165	general secretion pathway protein
JHW33_RS18280	COG1459	type II secretion system
JHW33_RS18285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JHW33_RS18290	COG1450	Type ii and iii secretion system protein
JHW33_RS18300	COG3409	Peptidoglycan-binding domain 1 protein
JHW33_RS18300	COG3267	Type II secretory pathway component ExeA
JHW33_RS18310	COG0051	transcription antitermination factor activity, RNA binding
JHW33_RS18315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JHW33_RS18320	COG0088	Forms part of the polypeptide exit tunnel
JHW33_RS18325	COG0089	rRNA binding
JHW33_RS18335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
JHW33_RS18340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JHW33_RS18350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JHW33_RS18360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JHW33_RS18365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JHW33_RS18380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JHW33_RS18385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JHW33_RS18395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JHW33_RS18400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JHW33_RS18405	COG1841	ribosomal large subunit assembly
JHW33_RS18415	COG0201	protein transport
JHW33_RS18420	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JHW33_RS18425	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JHW33_RS18430	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JHW33_RS18435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JHW33_RS18440	COG0202	RNA polymerase activity
JHW33_RS18445	COG0203	ribosomal protein L17
JHW33_RS18455	COG0789	Transcriptional regulator
JHW33_RS18460	COG3036	rescue of stalled ribosome
JHW33_RS18465	COG1970	mechanosensitive ion channel activity
JHW33_RS18475	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JHW33_RS18475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JHW33_RS18480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JHW33_RS18485	COG0242	peptide deformylase activity
JHW33_RS18490	COG0758	DNA mediated transformation
JHW33_RS18495	COG2922	Belongs to the Smg family
JHW33_RS18500	COG0551	DNA topoisomerase type I activity
JHW33_RS18505	COG0009	L-threonylcarbamoyladenylate synthase
JHW33_RS18510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JHW33_RS18515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JHW33_RS18555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
JHW33_RS18560	COG3162	membrane
JHW33_RS18565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
JHW33_RS18570	COG3539	Fimbrial protein
JHW33_RS18575	COG3188	usher protein
JHW33_RS18580	COG3121	Chaperone
JHW33_RS18610	COG2271	Major facilitator Superfamily
JHW33_RS18615	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS18625	COG1309	transcriptional regulator
JHW33_RS18630	COG4232	protein-disulfide reductase activity
JHW33_RS18635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
JHW33_RS18650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JHW33_RS18670	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JHW33_RS18680	COG5510	response to toxic substance
JHW33_RS18685	COG3040	lipid binding
JHW33_RS18700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
JHW33_RS18705	COG1053	succinate dehydrogenase
JHW33_RS18710	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
JHW33_RS18715	COG2233	PERMEase
JHW33_RS18725	COG1511	domain protein
JHW33_RS18725	COG3264	Mechanosensitive ion channel
JHW33_RS18735	COG1162	GTPase activity
JHW33_RS18740	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
JHW33_RS18760	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JHW33_RS18765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JHW33_RS18765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
JHW33_RS18770	COG0802	atpase or kinase
JHW33_RS18775	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHW33_RS18780	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JHW33_RS18785	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JHW33_RS18790	COG1923	regulation of RNA biosynthetic process
JHW33_RS18795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JHW33_RS18800	COG0330	HflC and HflK could
JHW33_RS18805	COG0330	HflC and HflK could
JHW33_RS18810	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
JHW33_RS18815	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JHW33_RS18825	COG0557	exoribonuclease II activity
JHW33_RS18830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHW33_RS18835	COG1960	acyl-CoA dehydrogenase activity
JHW33_RS18845	COG0840	transmembrane signaling receptor activity
JHW33_RS18850	COG1073	alpha beta
JHW33_RS18855	COG0360	Binds together with S18 to 16S ribosomal RNA
JHW33_RS18865	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JHW33_RS18870	COG0359	binds to the 23S rRNA
JHW33_RS18875	COG3061	Opacity-associated protein A
JHW33_RS18880	COG0545	Peptidyl-prolyl cis-trans isomerase
JHW33_RS18890	COG0737	Belongs to the 5'-nucleotidase family
JHW33_RS18900	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
JHW33_RS18910	COG1253	flavin adenine dinucleotide binding
JHW33_RS18915	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS18920	COG0729	surface antigen
JHW33_RS18930	COG2105	PFAM AIG2 family protein
JHW33_RS18935	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
JHW33_RS18945	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
JHW33_RS18950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JHW33_RS18975	COG3423	Transcriptional regulator
JHW33_RS18985	COG0142	geranyltranstransferase activity
JHW33_RS18990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JHW33_RS19000	COG0697	spore germination
JHW33_RS19005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JHW33_RS19010	COG0642	Histidine kinase
JHW33_RS19015	COG0745	RESPONSE REGULATOR receiver
JHW33_RS19020	COG2027	D-alanyl-D-alanine carboxypeptidase
JHW33_RS19030	COG1534	Rna-binding protein
JHW33_RS19035	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
JHW33_RS19045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
JHW33_RS19050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JHW33_RS19055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JHW33_RS19070	COG0779	Required for maturation of 30S ribosomal subunits
JHW33_RS19075	COG0195	Participates in both transcription termination and antitermination
JHW33_RS19085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JHW33_RS19090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JHW33_RS19095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JHW33_RS19100	COG1185	polyribonucleotide nucleotidyltransferase activity
JHW33_RS19115	COG0513	Belongs to the DEAD box helicase family
JHW33_RS19120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
JHW33_RS19140	COG0826	peptidase U32
JHW33_RS19145	COG0826	peptidase U32
JHW33_RS19150	COG3154	lipid carrier protein
JHW33_RS19155	COG3153	acetyltransferase
JHW33_RS19165	COG3787	Belongs to the UPF0306 family
JHW33_RS19170	COG0702	epimerase
JHW33_RS19175	COG0110	maltose O-acetyltransferase activity
JHW33_RS19180	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
JHW33_RS19185	COG3454	Phosphonate metabolism
JHW33_RS19190	COG4778	phosphonate C-P lyase system protein PhnL
JHW33_RS19195	COG4107	phosphonate C-P lyase system protein PhnK
JHW33_RS19200	COG3627	carbon phosphorus lyase activity
JHW33_RS19205	COG3626	phosphonate metabolism
JHW33_RS19210	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
JHW33_RS19215	COG3624	Phosphonate C-P lyase system protein PhnG
JHW33_RS19220	COG2188	Transcriptional regulator
JHW33_RS19240	COG0602	queuosine metabolic process
JHW33_RS19250	COG0366	Alpha amylase catalytic
JHW33_RS19255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS19255	COG1263	PTS System
JHW33_RS19260	COG1609	Transcriptional regulator
JHW33_RS19265	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JHW33_RS19270	COG0861	Integral membrane protein TerC family
JHW33_RS19275	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHW33_RS19275	COG0519	Catalyzes the synthesis of GMP from XMP
JHW33_RS19280	COG0673	inositol 2-dehydrogenase activity
JHW33_RS19285	COG1451	nucleotide metabolic process
JHW33_RS19290	COG2813	Specifically methylates the guanine in position
JHW33_RS19295	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS19295	COG0446	pyridine nucleotide-disulphide oxidoreductase
JHW33_RS19300	COG1024	Enoyl-CoA hydratase
JHW33_RS19305	COG5001	Diguanylate cyclase
JHW33_RS19320	COG2909	trisaccharide binding
JHW33_RS19325	COG0058	SHG alpha-glucan phosphorylase activity
JHW33_RS19330	COG1640	4-alpha-glucanotransferase
JHW33_RS19335	COG3833	ABC-type maltose transport systems, permease component
JHW33_RS19340	COG1175	transmembrane transport
JHW33_RS19345	COG2182	Extracellular solute-binding protein
JHW33_RS19355	COG4580	involved in the transport of maltose and maltodextrins
JHW33_RS19380	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JHW33_RS19390	COG4771	TonB-dependent receptor
JHW33_RS19395	COG2382	esterase
JHW33_RS19400	COG1120	ATPase activity
JHW33_RS19405	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW33_RS19410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JHW33_RS19415	COG4592	Periplasmic binding protein
JHW33_RS19430	COG4974	Belongs to the 'phage' integrase family
JHW33_RS19485	COG1278	Cold shock
JHW33_RS19495	COG4695	Portal protein
JHW33_RS19645	COG3663	DNA glycosylase
JHW33_RS19670	COG0358	DNA primase activity
JHW33_RS19675	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JHW33_RS19690	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
JHW33_RS19695	COG1968	undecaprenyl-diphosphatase activity
JHW33_RS19700	COG0617	tRNA 3'-terminal CCA addition
JHW33_RS19705	COG4991	sh3 domain protein
JHW33_RS19710	COG3025	triphosphatase activity
JHW33_RS19715	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
JHW33_RS19720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
JHW33_RS19720	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
JHW33_RS19725	COG0531	amino acid
JHW33_RS19730	COG2960	long-chain fatty acid transporting porin activity
JHW33_RS19735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
JHW33_RS19745	COG3384	dioxygenase
JHW33_RS19750	COG0754	glutathionylspermidine amidase activity
JHW33_RS19755	COG5463	Belongs to the UPF0441 family
JHW33_RS19760	COG1538	Outer membrane efflux protein
JHW33_RS19765	COG0494	nUDIX hydrolase
JHW33_RS19770	COG3151	Protein conserved in bacteria
JHW33_RS19775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
JHW33_RS19780	COG3150	esterase
JHW33_RS19785	COG0187	DNA topoisomerase II activity
JHW33_RS19790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
JHW33_RS19795	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW33_RS19810	COG2132	Multicopper oxidase
JHW33_RS19815	COG0656	L-ascorbic acid biosynthetic process
JHW33_RS19820	COG1064	alcohol dehydrogenase
JHW33_RS19825	COG2207	Transcriptional regulator
JHW33_RS19830	COG0586	Pfam SNARE associated Golgi protein
JHW33_RS19835	COG0626	cystathionine gamma-synthase activity
JHW33_RS19850	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
JHW33_RS19860	COG0848	biopolymer transport protein
JHW33_RS19865	COG2721	sulfolactate sulfo-lyase activity
JHW33_RS19870	COG2271	Major facilitator Superfamily
JHW33_RS19880	COG2084	Dehydrogenase
JHW33_RS19885	COG1929	Belongs to the glycerate kinase type-1 family
JHW33_RS19900	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW33_RS19905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JHW33_RS19910	COG3956	TIGRFAM MazG family protein
JHW33_RS19915	COG0504	CTP synthase activity
JHW33_RS19920	COG0148	phosphopyruvate hydratase activity
JHW33_RS19930	COG1263	PTS System
JHW33_RS19930	COG2190	(PTS) system
JHW33_RS19930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS19935	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JHW33_RS19940	COG0602	queuosine metabolic process
JHW33_RS19945	COG0720	synthase
JHW33_RS19955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
JHW33_RS19960	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
JHW33_RS19965	COG0175	sulfate reduction
JHW33_RS19970	COG2234	aminopeptidase activity
JHW33_RS19975	COG1648	precorrin-2 dehydrogenase activity
JHW33_RS19975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
JHW33_RS19985	COG2895	sulfate adenylyltransferase (ATP) activity
JHW33_RS19990	COG0529	Catalyzes the synthesis of activated sulfate
JHW33_RS20000	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
JHW33_RS20010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JHW33_RS20015	COG0585	pseudouridine synthase activity
JHW33_RS20020	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
JHW33_RS20025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
JHW33_RS20030	COG1388	LysM domain
JHW33_RS20030	COG4942	peptidase
JHW33_RS20035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JHW33_RS20040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JHW33_RS20050	COG2951	lytic endotransglycosylase activity
JHW33_RS20060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JHW33_RS20065	COG2137	regulation of response to DNA damage stimulus
JHW33_RS20070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JHW33_RS20075	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
JHW33_RS20100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JHW33_RS20105	COG1238	metal cluster binding
JHW33_RS20110	COG2918	glutathione biosynthetic process
JHW33_RS20115	COG1854	S-ribosylhomocysteine lyase activity
JHW33_RS20120	COG4536	flavin adenine dinucleotide binding
JHW33_RS20125	COG4137	Cytochrome C assembly protein
JHW33_RS20130	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JHW33_RS20140	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JHW33_RS20150	COG0335	large ribosomal subunit rRNA binding
JHW33_RS20200	COG5301	cellulose 1,4-beta-cellobiosidase activity
JHW33_RS20200	COG5301	cellulose 1,4-beta-cellobiosidase activity
JHW33_RS20275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
JHW33_RS20280	COG1605	Chorismate mutase
JHW33_RS20280	COG0287	Prephenate dehydrogenase
JHW33_RS20285	COG1605	Chorismate mutase
JHW33_RS20285	COG0077	Prephenate dehydratase
JHW33_RS20290	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
JHW33_RS20295	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS20300	COG0564	pseudouridine synthase activity
JHW33_RS20305	COG1496	oxidoreductase activity
JHW33_RS20310	COG0542	response to heat
JHW33_RS20340	COG0477	Major facilitator Superfamily
JHW33_RS20345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JHW33_RS20350	COG1042	CoA-binding domain protein
JHW33_RS20350	COG0045	succinate-CoA ligase (ADP-forming) activity
JHW33_RS20350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JHW33_RS20355	COG3148	PFAM DTW domain containing protein
JHW33_RS20360	COG3118	belongs to the thioredoxin family
JHW33_RS20365	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JHW33_RS20370	COG2814	Major facilitator Superfamily
JHW33_RS20375	COG1566	PFAM secretion protein HlyD family protein
JHW33_RS20385	COG1846	Transcriptional regulator
JHW33_RS20395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JHW33_RS20405	COG2113	Glycine betaine
JHW33_RS20415	COG4176	ABC-type proline glycine betaine transport system permease component
JHW33_RS20420	COG4175	Glycine betaine
JHW33_RS20435	COG3493	citrate carrier protein
JHW33_RS20440	COG0791	NLP P60 protein
JHW33_RS20445	COG0667	Aldo Keto reductase
JHW33_RS20450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JHW33_RS20465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JHW33_RS20470	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JHW33_RS20480	COG2188	Transcriptional regulator
JHW33_RS20485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS20485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JHW33_RS20485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JHW33_RS20490	COG0383	alpha-mannosidase activity
JHW33_RS20495	COG4575	ribosome binding
JHW33_RS20520	COG1105	Belongs to the carbohydrate kinase PfkB family
JHW33_RS20530	COG0354	folic acid binding
JHW33_RS20545	COG0716	FMN binding
JHW33_RS20550	COG4974	Belongs to the 'phage' integrase family
JHW33_RS20555	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
JHW33_RS20560	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JHW33_RS20570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JHW33_RS20580	COG3423	Transcriptional regulator
JHW33_RS20590	COG0583	DNA-binding transcription factor activity
JHW33_RS20595	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHW33_RS20600	COG3366	ferrous iron transmembrane transporter activity
JHW33_RS20605	COG0700	Nucleoside recognition
JHW33_RS20610	COG1473	amidohydrolase
JHW33_RS20615	COG1522	sequence-specific DNA binding
JHW33_RS20640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JHW33_RS20645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW33_RS20650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS20690	COG2852	Protein conserved in bacteria
JHW33_RS20695	COG3423	Transcriptional regulator
JHW33_RS20715	COG1263	PTS System
JHW33_RS20715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS20720	COG2188	Transcriptional regulator
JHW33_RS20725	COG4178	(ABC) transporter
JHW33_RS20740	COG0583	DNA-binding transcription factor activity
JHW33_RS20745	COG2814	Major facilitator Superfamily
JHW33_RS20750	COG0583	DNA-binding transcription factor activity
JHW33_RS20760	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHW33_RS20765	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS20770	COG2723	6-phospho-beta-galactosidase activity
JHW33_RS20780	COG2186	Transcriptional regulator
JHW33_RS20790	COG1609	Transcriptional regulator
JHW33_RS20810	COG0667	Aldo Keto reductase
JHW33_RS20825	COG0494	nUDIX hydrolase
JHW33_RS20835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JHW33_RS20840	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JHW33_RS20850	COG4795	General secretion pathway protein
JHW33_RS20875	COG0860	N-Acetylmuramoyl-L-alanine amidase
JHW33_RS20895	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
JHW33_RS20900	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JHW33_RS20905	COG2166	iron-sulfur cluster assembly
JHW33_RS20910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JHW33_RS20920	COG0583	DNA-binding transcription factor activity
JHW33_RS20925	COG2363	Small membrane protein
JHW33_RS20930	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
JHW33_RS20935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JHW33_RS20940	COG1611	Belongs to the LOG family
JHW33_RS20945	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHW33_RS20945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
JHW33_RS20955	COG2814	Major facilitator Superfamily
JHW33_RS20960	COG3098	single-species biofilm formation
JHW33_RS20975	COG3385	transposase activity
JHW33_RS20990	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
JHW33_RS21000	COG0052	Belongs to the universal ribosomal protein uS2 family
JHW33_RS21005	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JHW33_RS21015	COG0233	cytoplasmic translational termination
JHW33_RS21020	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
JHW33_RS21030	COG0575	Belongs to the CDS family
JHW33_RS21035	COG0750	zinc metalloprotease
JHW33_RS21040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS21045	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
JHW33_RS21050	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW33_RS21055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHW33_RS21065	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
JHW33_RS21070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JHW33_RS21080	COG0825	malonyl-CoA metabolic process
JHW33_RS21085	COG1982	Orn Lys Arg decarboxylase major
JHW33_RS21090	COG0346	lactoylglutathione lyase activity
JHW33_RS21095	COG0037	tRNA processing
JHW33_RS21105	COG4568	rho-dependent transcription termination
JHW33_RS21125	COG3015	lipoprotein NlpE involved in copper resistance
JHW33_RS21130	COG0442	prolyl-tRNA aminoacylation
JHW33_RS21135	COG1720	tRNA m6t6A37 methyltransferase activity
JHW33_RS21145	COG1464	Belongs to the NlpA lipoprotein family
JHW33_RS21150	COG2011	ABC-type metal ion transport system permease component
JHW33_RS21155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JHW33_RS21160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
JHW33_RS21205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW33_RS21220	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JHW33_RS21225	COG0463	Glycosyl transferase, family 2
JHW33_RS21250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW33_RS21260	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS21265	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JHW33_RS21280	COG0583	DNA-binding transcription factor activity
JHW33_RS21285	COG2814	Major facilitator Superfamily
JHW33_RS21290	COG3021	interspecies interaction between organisms
JHW33_RS21295	COG0741	lytic transglycosylase activity
JHW33_RS21295	COG1388	LysM domain
JHW33_RS21300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JHW33_RS21305	COG2226	methyltransferase
JHW33_RS21310	COG0328	RNA-DNA hybrid ribonuclease activity
JHW33_RS21315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
JHW33_RS21320	COG2957	Belongs to the agmatine deiminase family
JHW33_RS21325	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW33_RS21335	COG1953	Uracil, thiamine, allantoin
JHW33_RS21390	COG0765	amino acid transport
JHW33_RS21395	COG1126	abc transporter atp-binding protein
JHW33_RS21400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JHW33_RS21420	COG0504	CTP synthase activity
JHW33_RS21435	COG0436	Aminotransferase
JHW33_RS21440	COG0235	Class ii aldolase
JHW33_RS21445	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
JHW33_RS21450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
JHW33_RS21455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
JHW33_RS21460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
JHW33_RS21465	COG4807	Protein conserved in bacteria
JHW33_RS21480	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JHW33_RS21485	COG0121	glutamine amidotransferase
JHW33_RS21490	COG3034	peptidoglycan biosynthetic process
JHW33_RS21495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JHW33_RS21500	COG2195	Cleaves the N-terminal amino acid of tripeptides
JHW33_RS21505	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
JHW33_RS21510	COG1073	alpha beta
JHW33_RS21530	COG0583	DNA-binding transcription factor activity
JHW33_RS21600	COG0667	Aldo Keto reductase
JHW33_RS21605	COG0656	L-ascorbic acid biosynthetic process
JHW33_RS21625	COG3042	response to heat
JHW33_RS21630	COG0840	transmembrane signaling receptor activity
JHW33_RS21635	COG1473	amidohydrolase
JHW33_RS21640	COG2171	N-acyltransferase activity
JHW33_RS21645	COG0840	transmembrane signaling receptor activity
JHW33_RS21655	COG1879	ABC-type sugar transport system periplasmic component
JHW33_RS21660	COG1129	ABC transporter
JHW33_RS21665	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS21670	COG1737	Transcriptional regulator
JHW33_RS21675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JHW33_RS21685	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS21690	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
JHW33_RS21695	COG1074	ATP-dependent DNA helicase activity
JHW33_RS21700	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JHW33_RS21730	COG0583	DNA-binding transcription factor activity
JHW33_RS21765	COG1278	Cold shock
JHW33_RS21780	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS21790	COG2223	nitrite transmembrane transporter activity
JHW33_RS21810	COG2205	protein histidine kinase activity
JHW33_RS21815	COG3170	Tfp pilus assembly protein FimV
JHW33_RS21820	COG2204	response regulator
JHW33_RS21825	COG0347	Belongs to the P(II) protein family
JHW33_RS21845	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
JHW33_RS21845	COG1017	nitric oxide dioxygenase activity
JHW33_RS21850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JHW33_RS21855	COG2814	Major facilitator Superfamily
JHW33_RS21860	COG3711	transcriptional antiterminator
JHW33_RS21865	COG3683	transport system, periplasmic component
JHW33_RS21870	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
JHW33_RS21875	COG0483	inositol monophosphate 1-phosphatase activity
JHW33_RS21880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
JHW33_RS21885	COG1959	2 iron, 2 sulfur cluster binding
JHW33_RS21890	COG1104	cysteine desulfurase activity
JHW33_RS21895	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
JHW33_RS21905	COG0105	UTP biosynthetic process
JHW33_RS21910	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JHW33_RS21925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JHW33_RS21930	COG0124	histidyl-tRNA synthetase
JHW33_RS21935	COG2976	Protein conserved in bacteria
JHW33_RS21940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS21945	COG1160	GTP binding
JHW33_RS21955	COG1645	bacterial-type flagellum-dependent swarming motility
JHW33_RS21975	COG2271	Major facilitator Superfamily
JHW33_RS21985	COG1570	exodeoxyribonuclease VII activity
JHW33_RS21990	COG0517	IMP dehydrogenase activity
JHW33_RS21990	COG0516	GMP reductase activity
JHW33_RS21995	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JHW33_RS21995	COG0519	Catalyzes the synthesis of GMP from XMP
JHW33_RS22005	COG2249	NAD(P)H dehydrogenase (quinone) activity
JHW33_RS22010	COG0583	DNA-binding transcription factor activity
JHW33_RS22015	COG3385	transposase activity
JHW33_RS22030	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
JHW33_RS22035	COG0351	phosphomethylpyrimidine kinase
JHW33_RS22045	COG1802	Transcriptional regulator
JHW33_RS22055	COG2211	Major facilitator Superfamily
JHW33_RS22065	COG1605	Chorismate mutase
JHW33_RS22070	COG2271	Major facilitator Superfamily
JHW33_RS22075	COG1063	alcohol dehydrogenase
JHW33_RS22080	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS22090	COG2211	Major facilitator Superfamily
JHW33_RS22095	COG1597	lipid kinase activity
JHW33_RS22100	COG0826	peptidase U32
JHW33_RS22105	COG3422	double-strand break repair
JHW33_RS22110	COG0745	RESPONSE REGULATOR receiver
JHW33_RS22115	COG2205	protein histidine kinase activity
JHW33_RS22120	COG2814	Major facilitator Superfamily
JHW33_RS22125	COG0667	Aldo Keto reductase
JHW33_RS22130	COG0443	Heat shock 70 kDa protein
JHW33_RS22135	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
JHW33_RS22140	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
JHW33_RS22150	COG1957	nucleoside hydrolase
JHW33_RS22160	COG0408	coproporphyrinogen oxidase activity
JHW33_RS22170	COG0456	acetyltransferase
JHW33_RS22175	COG3111	PFAM Bacterial OB fold (BOF) protein
JHW33_RS22190	COG2837	iron assimilation
JHW33_RS22200	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
JHW33_RS22205	COG4208	sulfate ABC transporter
JHW33_RS22220	COG0745	RESPONSE REGULATOR receiver
JHW33_RS22225	COG2205	protein histidine kinase activity
JHW33_RS22235	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JHW33_RS22255	COG3115	cell septum assembly
JHW33_RS22260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JHW33_RS22265	COG3530	Putative quorum-sensing-regulated virulence factor
JHW33_RS22270	COG0385	Bile acid
JHW33_RS22275	COG0583	DNA-binding transcription factor activity
JHW33_RS22290	COG0531	amino acid
JHW33_RS22295	COG4303	Ethanolamine ammonia lyase large subunit
JHW33_RS22300	COG4302	ethanolamine ammonia-lyase activity
JHW33_RS22330	COG2116	formate transmembrane transporter activity
JHW33_RS22350	COG3385	transposase activity
JHW33_RS22355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JHW33_RS22360	COG1914	H( )-stimulated, divalent metal cation uptake system
JHW33_RS22370	COG0667	Aldo Keto reductase
JHW33_RS22440	COG0250	Participates in transcription elongation, termination and antitermination
JHW33_RS22570	COG2336	PFAM SpoVT AbrB
JHW33_RS22575	COG2337	Toxic component of a toxin-antitoxin (TA) module
JHW33_RS22745	COG3706	GGDEF domain
JHW33_RS22780	COG2205	protein histidine kinase activity
JHW33_RS22870	COG1733	regulation of RNA biosynthetic process
JHW33_RS22965	COG1486	melibiose metabolic process
JHW33_RS22970	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHW33_RS22975	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS22975	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS22985	COG2188	Transcriptional regulator
JHW33_RS22995	COG0484	heat shock protein binding
JHW33_RS23025	COG2186	Transcriptional regulator
JHW33_RS23035	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS23040	COG2271	Major facilitator Superfamily
JHW33_RS23045	COG1063	alcohol dehydrogenase
JHW33_RS23065	COG3713	MltA-interacting MipA family protein
JHW33_RS23075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
JHW33_RS23090	COG1309	transcriptional regulator
JHW33_RS23150	COG3547	Transposase (IS116 IS110 IS902 family)
JHW33_RS23230	COG3547	Transposase (IS116 IS110 IS902 family)
JHW33_RS23270	COG2944	sequence-specific DNA binding
JHW33_RS23395	COG1764	response to oxidative stress
JHW33_RS23420	COG0500	methyltransferase
JHW33_RS23425	COG2200	EAL domain
JHW33_RS23485	COG1609	Transcriptional regulator
JHW33_RS23490	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS23495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JHW33_RS23500	COG1447	Phosphotransferase system cellobiose-specific component IIA
JHW33_RS23505	COG2169	Transcriptional regulator
JHW33_RS23505	COG1917	Cupin 2, conserved barrel domain protein
JHW33_RS23510	COG1486	melibiose metabolic process
JHW33_RS23525	COG0583	DNA-binding transcription factor activity
JHW33_RS23540	COG1733	regulation of RNA biosynthetic process
JHW33_RS23545	COG0702	epimerase
JHW33_RS23555	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JHW33_RS23560	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
JHW33_RS23585	COG2211	Major facilitator Superfamily
JHW33_RS23595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS23600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS23660	COG0738	Major facilitator superfamily
JHW33_RS23665	COG3254	rhamnose metabolic process
JHW33_RS23670	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS23680	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS23685	COG0179	Fumarylacetoacetate (FAA) hydrolase
JHW33_RS23690	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS23695	COG2186	Transcriptional regulator
JHW33_RS23705	COG1294	oxidase, subunit
JHW33_RS23710	COG1271	oxidase subunit
JHW33_RS23720	COG2207	Transcriptional regulator
JHW33_RS23725	COG2267	carboxylic ester hydrolase activity
JHW33_RS23735	COG0601	transmembrane transport
JHW33_RS23740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS23745	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS23750	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS23775	COG1294	oxidase, subunit
JHW33_RS23780	COG1271	oxidase subunit
JHW33_RS23850	COG0840	transmembrane signaling receptor activity
JHW33_RS23855	COG0840	transmembrane signaling receptor activity
JHW33_RS23875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
JHW33_RS23880	COG2207	Transcriptional regulator
JHW33_RS23880	COG3708	Transcriptional regulator
JHW33_RS23905	COG0582	viral genome integration into host DNA
JHW33_RS23925	COG5532	Uncharacterized conserved protein (DUF2303)
JHW33_RS23995	COG4725	Belongs to the MT-A70-like family
JHW33_RS24005	COG1403	HNH endonuclease
JHW33_RS24070	COG2207	Transcriptional regulator
JHW33_RS24075	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS24090	COG0823	Involved in the tonB-independent uptake of proteins
JHW33_RS24095	COG0477	Major facilitator Superfamily
JHW33_RS24115	COG0443	Heat shock 70 kDa protein
JHW33_RS24120	COG1309	transcriptional regulator
JHW33_RS24130	COG1830	Aldolase
JHW33_RS24155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS24200	COG0371	Dehydrogenase
JHW33_RS24225	COG2990	Protein conserved in bacteria
JHW33_RS24255	COG1283	sodium-dependent phosphate transmembrane transporter activity
JHW33_RS24290	COG4319	ketosteroid isomerase
JHW33_RS24295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JHW33_RS24310	COG3141	response to X-ray
JHW33_RS24325	COG4773	Receptor
JHW33_RS24330	COG1649	PFAM Uncharacterised BCR, COG1649
JHW33_RS24345	COG1073	alpha beta
JHW33_RS24350	COG1902	pentaerythritol trinitrate reductase activity
JHW33_RS24355	COG0640	Transcriptional regulator
JHW33_RS24360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
JHW33_RS24365	COG1393	Belongs to the ArsC family
JHW33_RS24380	COG4774	siderophore transport
JHW33_RS24395	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS24400	COG5455	response to cobalt ion
JHW33_RS24405	COG3290	protein histidine kinase activity
JHW33_RS24410	COG4565	transcriptional regulatory protein
JHW33_RS24430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
JHW33_RS24430	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
JHW33_RS24440	COG0281	malic enzyme
JHW33_RS24470	COG0488	(ABC) transporter
JHW33_RS24480	COG0814	amino acid
JHW33_RS24490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW33_RS24495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JHW33_RS24500	COG1121	(ABC) transporter
JHW33_RS24510	COG1321	iron dependent repressor
JHW33_RS24525	COG0561	phosphatase activity
JHW33_RS24530	COG2223	nitrite transmembrane transporter activity
JHW33_RS24545	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
JHW33_RS24645	COG1971	Probably functions as a manganese efflux pump
JHW33_RS24650	COG0583	DNA-binding transcription factor activity
JHW33_RS24660	COG0859	PFAM glycosyl transferase family 9
JHW33_RS24670	COG0667	Aldo Keto reductase
JHW33_RS24685	COG3264	Mechanosensitive ion channel
JHW33_RS24685	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
JHW33_RS24695	COG1454	alcohol dehydrogenase
JHW33_RS24700	COG1309	transcriptional regulator
JHW33_RS24705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
JHW33_RS24710	COG1131	(ABC) transporter
JHW33_RS24715	COG0842	Transport permease protein
JHW33_RS24720	COG0842	Transport permease protein
JHW33_RS24725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JHW33_RS24730	COG1473	amidohydrolase
JHW33_RS24775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JHW33_RS24785	COG2723	6-phospho-beta-galactosidase activity
JHW33_RS24790	COG1966	Carbon starvation protein
JHW33_RS24795	COG2879	small protein
JHW33_RS24800	COG0523	cobalamin synthesis protein
JHW33_RS24810	COG3275	phosphorelay sensor kinase activity
JHW33_RS24830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
JHW33_RS24835	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JHW33_RS24845	COG0668	transmembrane transport
JHW33_RS24850	COG0076	glutamate decarboxylase activity
JHW33_RS24855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS24875	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS24880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS24885	COG0601	transmembrane transport
JHW33_RS24900	COG4773	Receptor
JHW33_RS24915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JHW33_RS24920	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
JHW33_RS24940	COG2203	Gaf domain
JHW33_RS24940	COG4251	negative regulation of phosphorylation
JHW33_RS24940	COG5001	Diguanylate cyclase
JHW33_RS24940	COG3706	GGDEF domain
JHW33_RS24945	COG1304	FMN binding
JHW33_RS25010	COG2076	Multidrug Resistance protein
JHW33_RS25020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JHW33_RS25025	COG5002	protein histidine kinase activity
JHW33_RS25030	COG0745	RESPONSE REGULATOR receiver
JHW33_RS25035	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
JHW33_RS25040	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
JHW33_RS25060	COG0024	Methionine aminopeptidase
JHW33_RS25065	COG1695	Transcriptional regulator
JHW33_RS25070	COG2375	cellular response to nickel ion
JHW33_RS25095	COG2995	paraquat-inducible protein a
JHW33_RS25100	COG3008	intermembrane lipid transfer
JHW33_RS25130	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JHW33_RS25135	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
JHW33_RS25165	COG4172	Belongs to the ABC transporter superfamily
JHW33_RS25185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS25200	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS25205	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS25210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JHW33_RS25215	COG0601	transmembrane transport
JHW33_RS25220	COG0747	negative chemotaxis
JHW33_RS25225	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS25230	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JHW33_RS25240	COG2814	Major facilitator Superfamily
JHW33_RS25245	COG2378	regulation of single-species biofilm formation
JHW33_RS25255	COG3813	Protein conserved in bacteria
JHW33_RS25265	COG0546	phosphoglycolate phosphatase activity
JHW33_RS25275	COG0583	DNA-binding transcription factor activity
JHW33_RS25280	COG3268	Saccharopine dehydrogenase
JHW33_RS25310	COG4993	Dehydrogenase
JHW33_RS25315	COG4772	TonB-dependent receptor
JHW33_RS25335	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS25350	COG1129	ABC transporter
JHW33_RS25355	COG1172	Belongs to the binding-protein-dependent transport system permease family
JHW33_RS25370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JHW33_RS25375	COG3209	COG3209 Rhs family protein
JHW33_RS25385	COG3209	COG3209 Rhs family protein
JHW33_RS25395	COG3209	COG3209 Rhs family protein
JHW33_RS25420	COG3209	COG3209 Rhs family protein
JHW33_RS25435	COG3501	Rhs element vgr protein
JHW33_RS25530	COG3038	cytochrome b561
JHW33_RS25535	COG2916	Histone family protein nucleoid-structuring protein H-NS
JHW33_RS25540	COG0583	DNA-binding transcription factor activity
JHW33_RS25545	COG1012	belongs to the aldehyde dehydrogenase family
JHW33_RS25565	COG2314	TM2 domain
JHW33_RS25570	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JHW33_RS25585	COG2814	Major facilitator Superfamily
JHW33_RS25590	COG1802	Transcriptional regulator
JHW33_RS25595	COG3706	GGDEF domain
JHW33_RS25600	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS25610	COG1028	Short-chain dehydrogenase reductase Sdr
JHW33_RS25615	COG1177	transmembrane transport
JHW33_RS25620	COG1176	ABC-type spermidine putrescine transport system, permease component I
JHW33_RS25630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
JHW33_RS25640	COG3842	ATPase activity
JHW33_RS25645	COG1192	Involved in chromosome partitioning
JHW33_RS25680	COG0747	negative chemotaxis
JHW33_RS25685	COG0601	transmembrane transport
JHW33_RS25695	COG0444	Belongs to the ABC transporter superfamily
JHW33_RS25700	COG4608	Belongs to the ABC transporter superfamily
JHW33_RS25705	COG0583	DNA-binding transcription factor activity
JHW33_RS25715	COG1263	PTS System
JHW33_RS25715	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JHW33_RS25715	COG2190	(PTS) system
JHW33_RS25720	COG4948	Mandelate Racemase Muconate Lactonizing
JHW33_RS25725	COG2188	Transcriptional regulator
JHW33_RS25735	COG3550	peptidyl-serine autophosphorylation
JHW33_RS25740	COG4993	Dehydrogenase
JHW33_RS25750	COG0747	negative chemotaxis
JHW33_RS25755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
JHW33_RS25765	COG1957	nucleoside hydrolase
JHW33_RS25770	COG0601	transmembrane transport
JHW33_RS25790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JHW33_RS25820	COG1136	(ABC) transporter
JHW33_RS25820	COG0577	efflux transmembrane transporter activity
JHW33_RS25825	COG0577	efflux transmembrane transporter activity
JHW33_RS25825	COG1136	(ABC) transporter
JHW33_RS25875	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JHW33_RS25890	COG1960	acyl-CoA dehydrogenase activity
JHW33_RS25905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JHW33_RS25915	COG0318	PFAM AMP-dependent synthetase and ligase