locus-tag	class	description
RPIC12D_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIC12D_RS00010	COG0592	DNA-directed DNA polymerase activity
RPIC12D_RS00025	COG0187	DNA topoisomerase II activity
RPIC12D_RS00035	COG3328	transposase activity
RPIC12D_RS00065	COG0765	amino acid transport
RPIC12D_RS00070	COG0765	amino acid transport
RPIC12D_RS00080	COG3781	membrane
RPIC12D_RS00095	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS00110	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS00115	COG1595	DNA-templated transcription, initiation
RPIC12D_RS00120	COG0784	Response regulator, receiver
RPIC12D_RS00120	COG4191	Histidine kinase
RPIC12D_RS00130	COG0517	IMP dehydrogenase activity
RPIC12D_RS00130	COG0516	GMP reductase activity
RPIC12D_RS00140	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RPIC12D_RS00150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RPIC12D_RS00160	COG1560	Kdo2-lipid A biosynthetic process
RPIC12D_RS00165	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RPIC12D_RS00170	COG2326	polyphosphate kinase activity
RPIC12D_RS00175	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIC12D_RS00180	COG0708	Exodeoxyribonuclease III
RPIC12D_RS00185	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIC12D_RS00195	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RPIC12D_RS00210	COG0697	spore germination
RPIC12D_RS00220	COG2223	nitrite transmembrane transporter activity
RPIC12D_RS00230	COG4221	oxidoreductase activity
RPIC12D_RS00245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIC12D_RS00250	COG0583	DNA-binding transcription factor activity
RPIC12D_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC12D_RS00265	COG1131	(ABC) transporter
RPIC12D_RS00270	COG0842	Transport permease protein
RPIC12D_RS00315	COG3501	Rhs element vgr protein
RPIC12D_RS00320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPIC12D_RS00325	COG0037	tRNA processing
RPIC12D_RS00330	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIC12D_RS00335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RPIC12D_RS00355	COG0604	alcohol dehydrogenase
RPIC12D_RS00360	COG0583	DNA-binding transcription factor activity
RPIC12D_RS00365	COG0028	Belongs to the TPP enzyme family
RPIC12D_RS00390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC12D_RS00400	COG0346	lactoylglutathione lyase activity
RPIC12D_RS00410	COG2814	Major facilitator Superfamily
RPIC12D_RS00415	COG0625	glutathione transferase activity
RPIC12D_RS00440	COG3328	transposase activity
RPIC12D_RS00460	COG0004	ammonium transporteR
RPIC12D_RS00470	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS00470	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS00470	COG1703	isobutyryl-CoA mutase activity
RPIC12D_RS00475	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS00495	COG0583	DNA-binding transcription factor activity
RPIC12D_RS00515	COG0693	protein deglycase activity
RPIC12D_RS00520	COG0596	Alpha beta hydrolase
RPIC12D_RS00535	COG4774	siderophore transport
RPIC12D_RS00540	COG1024	Enoyl-CoA hydratase
RPIC12D_RS00550	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS00555	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS00560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIC12D_RS00565	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS00575	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS00605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIC12D_RS00610	COG4770	biotin carboxylase activity
RPIC12D_RS00615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RPIC12D_RS00630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIC12D_RS00635	COG3012	SEC-C Motif Domain Protein
RPIC12D_RS00640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPIC12D_RS00650	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS00660	COG0183	Belongs to the thiolase family
RPIC12D_RS00665	COG0288	reversible hydration of carbon dioxide
RPIC12D_RS00670	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RPIC12D_RS00675	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS00680	COG0789	Transcriptional regulator
RPIC12D_RS00690	COG2329	Antibiotic biosynthesis monooxygenase
RPIC12D_RS00700	COG4221	oxidoreductase activity
RPIC12D_RS00705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RPIC12D_RS00715	COG0018	arginyl-trna synthetase
RPIC12D_RS00755	COG2197	response regulator
RPIC12D_RS00765	COG0646	methionine synthase
RPIC12D_RS00765	COG1410	methionine synthase
RPIC12D_RS00785	COG2267	carboxylic ester hydrolase activity
RPIC12D_RS00810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC12D_RS00845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RPIC12D_RS00855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RPIC12D_RS00860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RPIC12D_RS00860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RPIC12D_RS00865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RPIC12D_RS00890	COG2814	Major facilitator Superfamily
RPIC12D_RS00895	COG4264	IucA IucC family
RPIC12D_RS00900	COG3511	phospholipase C
RPIC12D_RS00910	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RPIC12D_RS00915	COG0321	lipoyl(octanoyl) transferase activity
RPIC12D_RS00925	COG0583	DNA-binding transcription factor activity
RPIC12D_RS00930	COG2921	Belongs to the UPF0250 family
RPIC12D_RS00935	COG1686	Belongs to the peptidase S11 family
RPIC12D_RS00940	COG2945	thiolester hydrolase activity
RPIC12D_RS00945	COG3411	Ferredoxin
RPIC12D_RS00950	COG1301	dicarboxylic acid transport
RPIC12D_RS00960	COG2204	response regulator
RPIC12D_RS00975	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RPIC12D_RS00985	COG1280	lysine exporter protein (LysE YggA)
RPIC12D_RS00990	COG0606	chelatase, subunit chli
RPIC12D_RS01000	COG1959	2 iron, 2 sulfur cluster binding
RPIC12D_RS01080	COG0004	ammonium transporteR
RPIC12D_RS01090	COG0189	ligase activity
RPIC12D_RS01100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIC12D_RS01105	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC12D_RS01125	COG0793	Belongs to the peptidase S41A family
RPIC12D_RS01130	COG0588	phosphoglycerate mutase activity
RPIC12D_RS01135	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIC12D_RS01140	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RPIC12D_RS01145	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RPIC12D_RS01150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RPIC12D_RS01160	COG1040	competence protein
RPIC12D_RS01165	COG2226	methyltransferase
RPIC12D_RS01180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIC12D_RS01185	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RPIC12D_RS01215	COG1612	heme a metabolic process
RPIC12D_RS01220	COG0109	protoheme IX farnesyltransferase activity
RPIC12D_RS01225	COG1999	signal sequence binding
RPIC12D_RS01230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPIC12D_RS01245	COG1741	Belongs to the pirin family
RPIC12D_RS01250	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIC12D_RS01255	COG3328	transposase activity
RPIC12D_RS01260	COG3328	transposase activity
RPIC12D_RS01265	COG3328	transposase activity
RPIC12D_RS01270	COG1116	anion transmembrane transporter activity
RPIC12D_RS01275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC12D_RS01280	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC12D_RS01285	COG3707	response regulator
RPIC12D_RS01295	COG0625	glutathione transferase activity
RPIC12D_RS01335	COG0612	Peptidase, M16
RPIC12D_RS01340	COG0612	Peptidase, M16
RPIC12D_RS01345	COG0742	ribosomal rna small subunit methyltransferase
RPIC12D_RS01350	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPIC12D_RS01355	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPIC12D_RS01365	COG0193	aminoacyl-tRNA hydrolase activity
RPIC12D_RS01370	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RPIC12D_RS01375	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIC12D_RS01385	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RPIC12D_RS01390	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RPIC12D_RS01400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIC12D_RS01420	COG1660	Displays ATPase and GTPase activities
RPIC12D_RS01430	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RPIC12D_RS01440	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RPIC12D_RS01445	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RPIC12D_RS01450	COG1137	ATPase activity
RPIC12D_RS01465	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RPIC12D_RS01485	COG0693	protein deglycase activity
RPIC12D_RS01490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RPIC12D_RS01495	COG1280	lysine exporter protein (LysE YggA)
RPIC12D_RS01510	COG2814	Major facilitator Superfamily
RPIC12D_RS01515	COG0629	single-stranded DNA binding
RPIC12D_RS01520	COG5002	protein histidine kinase activity
RPIC12D_RS01525	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS01530	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RPIC12D_RS01535	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIC12D_RS01575	COG2409	Drug exporters of the RND superfamily
RPIC12D_RS01590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPIC12D_RS01625	COG3258	Cytochrome c
RPIC12D_RS01650	COG3265	gluconokinase activity
RPIC12D_RS01655	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS01685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RPIC12D_RS01685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RPIC12D_RS01690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RPIC12D_RS01700	COG0700	Nucleoside recognition
RPIC12D_RS01705	COG1238	metal cluster binding
RPIC12D_RS01720	COG4178	(ABC) transporter
RPIC12D_RS01730	COG2226	methyltransferase
RPIC12D_RS01745	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIC12D_RS01750	COG0500	methyltransferase
RPIC12D_RS01770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPIC12D_RS01780	COG0494	nUDIX hydrolase
RPIC12D_RS01785	COG3568	Endonuclease Exonuclease Phosphatase
RPIC12D_RS01790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIC12D_RS01805	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS01810	COG1024	Enoyl-CoA hydratase
RPIC12D_RS01810	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS01815	COG0183	Belongs to the thiolase family
RPIC12D_RS01825	COG1024	Enoyl-CoA hydratase
RPIC12D_RS01830	COG1607	acyl-coa hydrolase
RPIC12D_RS01835	COG5265	(ABC) transporter
RPIC12D_RS01845	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RPIC12D_RS01855	COG0765	amino acid transport
RPIC12D_RS01860	COG0765	amino acid transport
RPIC12D_RS01865	COG1126	abc transporter atp-binding protein
RPIC12D_RS01870	COG0121	glutamine amidotransferase
RPIC12D_RS01880	COG0418	dihydroorotase activity
RPIC12D_RS01895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RPIC12D_RS01900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RPIC12D_RS01915	COG0316	Belongs to the HesB IscA family
RPIC12D_RS01920	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RPIC12D_RS01925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RPIC12D_RS01930	COG1490	D-aminoacyl-tRNA deacylase activity
RPIC12D_RS01945	COG2255	four-way junction helicase activity
RPIC12D_RS01950	COG0632	four-way junction helicase activity
RPIC12D_RS01960	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RPIC12D_RS01965	COG0138	bifunctional purine biosynthesis protein purh
RPIC12D_RS01970	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RPIC12D_RS01975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RPIC12D_RS01980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC12D_RS01985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPIC12D_RS01990	COG0006	proline dipeptidase activity
RPIC12D_RS02000	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPIC12D_RS02020	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RPIC12D_RS02025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC12D_RS02030	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RPIC12D_RS02035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPIC12D_RS02045	COG0346	lactoylglutathione lyase activity
RPIC12D_RS02055	COG0204	Acyl-transferase
RPIC12D_RS02060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RPIC12D_RS02065	COG0751	glycine-tRNA ligase activity
RPIC12D_RS02075	COG0752	glycyl-tRNA synthetase alpha subunit
RPIC12D_RS02080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RPIC12D_RS02085	COG4535	Mg2 and Co2 transporter CorC
RPIC12D_RS02105	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RPIC12D_RS02110	COG1702	phosphate starvation-inducible protein PhoH
RPIC12D_RS02115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIC12D_RS02140	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS02170	COG0513	Belongs to the DEAD box helicase family
RPIC12D_RS02190	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS02205	COG0583	DNA-binding transcription factor activity
RPIC12D_RS02215	COG2988	succinylglutamate desuccinylase activity
RPIC12D_RS02230	COG0596	Alpha beta hydrolase
RPIC12D_RS02230	COG2945	thiolester hydrolase activity
RPIC12D_RS02240	COG0477	Major facilitator Superfamily
RPIC12D_RS02245	COG3162	membrane
RPIC12D_RS02250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIC12D_RS02270	COG0642	Histidine kinase
RPIC12D_RS02280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RPIC12D_RS02285	COG2137	regulation of response to DNA damage stimulus
RPIC12D_RS02295	COG0045	succinate-CoA ligase (ADP-forming) activity
RPIC12D_RS02305	COG0861	Integral membrane protein TerC family
RPIC12D_RS02325	COG3307	-O-antigen
RPIC12D_RS02335	COG0315	cyclic pyranopterin monophosphate synthase activity
RPIC12D_RS02340	COG4783	chaperone-mediated protein folding
RPIC12D_RS02350	COG0429	hydrolase of the alpha beta-hydrolase fold
RPIC12D_RS02360	COG0859	PFAM glycosyl transferase family 9
RPIC12D_RS02385	COG0126	phosphoglycerate kinase activity
RPIC12D_RS02400	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPIC12D_RS02410	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RPIC12D_RS02415	COG0009	L-threonylcarbamoyladenylate synthase
RPIC12D_RS02425	COG1763	Mo-molybdopterin cofactor biosynthetic process
RPIC12D_RS02430	COG2027	D-alanyl-D-alanine carboxypeptidase
RPIC12D_RS02440	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPIC12D_RS02465	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RPIC12D_RS02475	COG0840	transmembrane signaling receptor activity
RPIC12D_RS02485	COG0154	amidase activity
RPIC12D_RS02565	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC12D_RS02575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPIC12D_RS02575	COG3008	intermembrane lipid transfer
RPIC12D_RS02580	COG2995	paraquat-inducible protein a
RPIC12D_RS02585	COG2995	paraquat-inducible protein a
RPIC12D_RS02605	COG0840	transmembrane signaling receptor activity
RPIC12D_RS02620	COG2329	Antibiotic biosynthesis monooxygenase
RPIC12D_RS02630	COG3268	Saccharopine dehydrogenase
RPIC12D_RS02650	COG0583	DNA-binding transcription factor activity
RPIC12D_RS02655	COG5001	Diguanylate cyclase
RPIC12D_RS02655	COG4251	negative regulation of phosphorylation
RPIC12D_RS02655	COG3706	GGDEF domain
RPIC12D_RS02655	COG2203	Gaf domain
RPIC12D_RS02660	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPIC12D_RS02665	COG0459	protein refolding
RPIC12D_RS02670	COG4269	membrane
RPIC12D_RS02685	COG0463	Glycosyl transferase, family 2
RPIC12D_RS02730	COG4964	Belongs to the GSP D family
RPIC12D_RS02765	COG1704	LemA family
RPIC12D_RS02775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC12D_RS02780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RPIC12D_RS02785	COG1773	rubredoxin
RPIC12D_RS02805	COG0840	transmembrane signaling receptor activity
RPIC12D_RS02810	COG2198	Histidine kinase
RPIC12D_RS02810	COG0784	Response regulator, receiver
RPIC12D_RS02810	COG0643	Histidine kinase
RPIC12D_RS02815	COG0415	Belongs to the DNA photolyase family
RPIC12D_RS02825	COG1678	Uncharacterized ACR, COG1678
RPIC12D_RS02830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RPIC12D_RS02835	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RPIC12D_RS02840	COG0540	Belongs to the ATCase OTCase family
RPIC12D_RS02855	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RPIC12D_RS02885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC12D_RS02890	COG1086	Polysaccharide biosynthesis protein
RPIC12D_RS02895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIC12D_RS02905	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
RPIC12D_RS02910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RPIC12D_RS02925	COG2089	acid synthase
RPIC12D_RS02945	COG0110	maltose O-acetyltransferase activity
RPIC12D_RS02960	COG0110	maltose O-acetyltransferase activity
RPIC12D_RS02965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIC12D_RS02990	COG0859	PFAM glycosyl transferase family 9
RPIC12D_RS03005	COG1538	Outer membrane efflux protein
RPIC12D_RS03015	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIC12D_RS03035	COG1968	undecaprenyl-diphosphatase activity
RPIC12D_RS03040	COG1902	pentaerythritol trinitrate reductase activity
RPIC12D_RS03045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RPIC12D_RS03050	COG0583	DNA-binding transcription factor activity
RPIC12D_RS03055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC12D_RS03060	COG0501	Belongs to the peptidase M48B family
RPIC12D_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC12D_RS03115	COG0542	response to heat
RPIC12D_RS03130	COG0542	response to heat
RPIC12D_RS03135	COG0071	Belongs to the small heat shock protein (HSP20) family
RPIC12D_RS03150	COG0583	DNA-binding transcription factor activity
RPIC12D_RS03165	COG1192	Involved in chromosome partitioning
RPIC12D_RS03220	COG0431	NADPH-dependent FMN reductase
RPIC12D_RS03235	COG0798	PFAM Bile acid sodium symporter
RPIC12D_RS03415	COG2003	Belongs to the UPF0758 family
RPIC12D_RS03475	COG0582	viral genome integration into host DNA
RPIC12D_RS03490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIC12D_RS03500	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RPIC12D_RS03510	COG0436	Aminotransferase
RPIC12D_RS03515	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIC12D_RS03520	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RPIC12D_RS03535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPIC12D_RS03535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPIC12D_RS03595	COG3328	transposase activity
RPIC12D_RS03600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RPIC12D_RS03605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RPIC12D_RS03610	COG4221	oxidoreductase activity
RPIC12D_RS03615	COG0824	Thioesterase
RPIC12D_RS03635	COG0823	Involved in the tonB-independent uptake of proteins
RPIC12D_RS03650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RPIC12D_RS03655	COG2391	methyltransferase activity
RPIC12D_RS03770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC12D_RS03785	COG1609	Transcriptional regulator
RPIC12D_RS03800	COG2175	clavaminate synthase activity
RPIC12D_RS03810	COG0390	transport system, permease component
RPIC12D_RS03815	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIC12D_RS03835	COG4575	ribosome binding
RPIC12D_RS03840	COG0450	alkyl hydroperoxide reductase
RPIC12D_RS03845	COG2252	PERMEase
RPIC12D_RS03850	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS03860	COG3483	tryptophan 2,3-dioxygenase activity
RPIC12D_RS03870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RPIC12D_RS03875	COG1522	sequence-specific DNA binding
RPIC12D_RS03885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RPIC12D_RS03905	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIC12D_RS03915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RPIC12D_RS03920	COG0259	pyridoxamine-phosphate oxidase activity
RPIC12D_RS03940	COG2982	Protein involved in outer membrane biogenesis
RPIC12D_RS03945	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RPIC12D_RS03955	COG2703	oxygen carrier activity
RPIC12D_RS03965	COG3118	belongs to the thioredoxin family
RPIC12D_RS03970	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS03980	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RPIC12D_RS03995	COG4681	YaeQ
RPIC12D_RS04020	COG2353	YceI-like domain
RPIC12D_RS04025	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC12D_RS04055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC12D_RS04060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIC12D_RS04075	COG4774	siderophore transport
RPIC12D_RS04080	COG0330	HflC and HflK could
RPIC12D_RS04095	COG0477	Major facilitator Superfamily
RPIC12D_RS04100	COG0235	Class ii aldolase
RPIC12D_RS04105	COG1942	4-Oxalocrotonate Tautomerase
RPIC12D_RS04120	COG0425	Belongs to the sulfur carrier protein TusA family
RPIC12D_RS04125	COG1280	lysine exporter protein (LysE YggA)
RPIC12D_RS04145	COG3121	Chaperone
RPIC12D_RS04155	COG2433	Pfam Transposase IS66
RPIC12D_RS04185	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RPIC12D_RS04210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RPIC12D_RS04215	COG1605	Chorismate mutase
RPIC12D_RS04215	COG0077	Prephenate dehydratase
RPIC12D_RS04220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIC12D_RS04225	COG0287	Prephenate dehydrogenase
RPIC12D_RS04230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RPIC12D_RS04235	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RPIC12D_RS04245	COG0776	regulation of translation
RPIC12D_RS04255	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RPIC12D_RS04265	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RPIC12D_RS04270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC12D_RS04285	COG2951	lytic endotransglycosylase activity
RPIC12D_RS04290	COG0123	including yeast histone deacetylase and acetoin utilization protein
RPIC12D_RS04295	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIC12D_RS04300	COG2011	ABC-type metal ion transport system permease component
RPIC12D_RS04305	COG1464	Belongs to the NlpA lipoprotein family
RPIC12D_RS04320	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS04325	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC12D_RS04365	COG0228	four-way junction DNA binding
RPIC12D_RS04370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RPIC12D_RS04375	COG0336	Belongs to the RNA methyltransferase TrmD family
RPIC12D_RS04380	COG0335	large ribosomal subunit rRNA binding
RPIC12D_RS04390	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RPIC12D_RS04400	COG1162	GTPase activity
RPIC12D_RS04405	COG0501	Belongs to the peptidase M48B family
RPIC12D_RS04410	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RPIC12D_RS04415	COG0521	Mo-molybdopterin cofactor biosynthetic process
RPIC12D_RS04420	COG3028	Belongs to the UPF0307 family
RPIC12D_RS04425	COG0312	modulator of DNA gyrase
RPIC12D_RS04435	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIC12D_RS04445	COG0861	Integral membrane protein TerC family
RPIC12D_RS04450	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RPIC12D_RS04455	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPIC12D_RS04460	COG0513	Belongs to the DEAD box helicase family
RPIC12D_RS04490	COG0488	(ABC) transporter
RPIC12D_RS04530	COG1132	(ABC) transporter
RPIC12D_RS04535	COG1620	l-lactate permease
RPIC12D_RS04550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIC12D_RS04565	COG0625	glutathione transferase activity
RPIC12D_RS04570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC12D_RS04580	COG0697	spore germination
RPIC12D_RS04585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIC12D_RS04595	COG0326	Molecular chaperone. Has ATPase activity
RPIC12D_RS04605	COG0840	transmembrane signaling receptor activity
RPIC12D_RS04635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPIC12D_RS04640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC12D_RS04670	COG0778	Nitroreductase
RPIC12D_RS04675	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RPIC12D_RS04680	COG2878	Part of a membrane complex involved in electron transport
RPIC12D_RS04685	COG1309	transcriptional regulator
RPIC12D_RS04700	COG0556	nucleotide-excision repair
RPIC12D_RS04710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC12D_RS04715	COG1609	Transcriptional regulator
RPIC12D_RS04720	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIC12D_RS04730	COG1879	ABC-type sugar transport system periplasmic component
RPIC12D_RS04740	COG1104	cysteine desulfurase activity
RPIC12D_RS04745	COG0822	iron-sulfur transferase activity
RPIC12D_RS04750	COG0316	Belongs to the HesB IscA family
RPIC12D_RS04760	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RPIC12D_RS04765	COG0443	Heat shock 70 kDa protein
RPIC12D_RS04785	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RPIC12D_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS04795	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIC12D_RS04800	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIC12D_RS04805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RPIC12D_RS04840	COG0746	molybdenum cofactor guanylyltransferase activity
RPIC12D_RS04845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RPIC12D_RS04850	COG1530	ribonuclease E activity
RPIC12D_RS04860	COG0546	phosphoglycolate phosphatase activity
RPIC12D_RS04870	COG0616	signal peptide processing
RPIC12D_RS04870	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIC12D_RS04875	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RPIC12D_RS04880	COG0424	maF-like protein
RPIC12D_RS04890	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RPIC12D_RS04895	COG0416	fatty acid biosynthetic process
RPIC12D_RS04900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPIC12D_RS04910	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPIC12D_RS04920	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPIC12D_RS04925	COG1595	DNA-templated transcription, initiation
RPIC12D_RS04940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC12D_RS04950	COG0481	GTPase activity
RPIC12D_RS04955	COG0681	Belongs to the peptidase S26 family
RPIC12D_RS04965	COG0571	ribonuclease III activity
RPIC12D_RS04970	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RPIC12D_RS04975	COG1381	Involved in DNA repair and RecF pathway recombination
RPIC12D_RS04980	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RPIC12D_RS04985	COG0736	holo-[acyl-carrier-protein] synthase activity
RPIC12D_RS04995	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RPIC12D_RS05005	COG0322	excinuclease ABC activity
RPIC12D_RS05035	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS05045	COG4251	negative regulation of phosphorylation
RPIC12D_RS05055	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS05065	COG2186	Transcriptional regulator
RPIC12D_RS05075	COG2271	Major facilitator Superfamily
RPIC12D_RS05085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS05140	COG2963	transposase activity
RPIC12D_RS05145	COG2801	Transposase and inactivated derivatives
RPIC12D_RS05170	COG1012	belongs to the aldehyde dehydrogenase family
RPIC12D_RS05180	COG0583	DNA-binding transcription factor activity
RPIC12D_RS05225	COG0210	DNA helicase
RPIC12D_RS05255	COG0583	DNA-binding transcription factor activity
RPIC12D_RS05260	COG2855	membrane
RPIC12D_RS05285	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RPIC12D_RS05300	COG1136	(ABC) transporter
RPIC12D_RS05305	COG0084	hydrolase, TatD family'
RPIC12D_RS05315	COG2308	Evidence 4 Homologs of previously reported genes of
RPIC12D_RS05335	COG2267	carboxylic ester hydrolase activity
RPIC12D_RS05340	COG0504	CTP synthase activity
RPIC12D_RS05345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RPIC12D_RS05355	COG0148	phosphopyruvate hydratase activity
RPIC12D_RS05360	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RPIC12D_RS05370	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RPIC12D_RS05380	COG2833	Protein of unknown function (DUF455)
RPIC12D_RS05385	COG2267	carboxylic ester hydrolase activity
RPIC12D_RS05390	COG3011	Protein conserved in bacteria
RPIC12D_RS05400	COG0492	ferredoxin-NADP+ reductase activity
RPIC12D_RS05405	COG0613	PHP domain protein
RPIC12D_RS05410	COG0009	L-threonylcarbamoyladenylate synthase
RPIC12D_RS05415	COG1994	Peptidase M50
RPIC12D_RS05420	COG0180	Tryptophanyl-tRNA synthetase
RPIC12D_RS05430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC12D_RS05435	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RPIC12D_RS05440	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RPIC12D_RS05450	COG2850	peptidyl-arginine hydroxylation
RPIC12D_RS05465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RPIC12D_RS05470	COG0583	DNA-binding transcription factor activity
RPIC12D_RS05475	COG0840	transmembrane signaling receptor activity
RPIC12D_RS05485	COG2258	MOSC domain
RPIC12D_RS05495	COG0483	inositol monophosphate 1-phosphatase activity
RPIC12D_RS05505	COG1045	serine acetyltransferase
RPIC12D_RS05510	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC12D_RS05515	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RPIC12D_RS05530	COG0215	cysteine-tRNA ligase activity
RPIC12D_RS05535	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RPIC12D_RS05540	COG0825	malonyl-CoA metabolic process
RPIC12D_RS05545	COG0037	tRNA processing
RPIC12D_RS05550	COG0527	aspartate kinase activity
RPIC12D_RS05565	COG4166	transmembrane transport
RPIC12D_RS05570	COG4174	ABC transporter (Permease)
RPIC12D_RS05575	COG4239	(ABC) transporter, permease
RPIC12D_RS05580	COG4172	Belongs to the ABC transporter superfamily
RPIC12D_RS05585	COG0791	NLP P60 protein
RPIC12D_RS05590	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPIC12D_RS05595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC12D_RS05615	COG0534	Mate efflux family protein
RPIC12D_RS05625	COG0254	rRNA binding
RPIC12D_RS05635	COG3228	Belongs to the MtfA family
RPIC12D_RS05640	COG2197	response regulator
RPIC12D_RS05650	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RPIC12D_RS05665	COG1074	ATP-dependent DNA helicase activity
RPIC12D_RS05670	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RPIC12D_RS05675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RPIC12D_RS05680	COG2329	Antibiotic biosynthesis monooxygenase
RPIC12D_RS05685	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RPIC12D_RS05700	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC12D_RS05705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC12D_RS05715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC12D_RS05720	COG1309	transcriptional regulator
RPIC12D_RS05725	COG1902	pentaerythritol trinitrate reductase activity
RPIC12D_RS05730	COG3321	synthase
RPIC12D_RS05730	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS05730	COG0604	alcohol dehydrogenase
RPIC12D_RS05735	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RPIC12D_RS05740	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIC12D_RS05745	COG1388	LysM domain
RPIC12D_RS05745	COG4942	peptidase
RPIC12D_RS05760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RPIC12D_RS05765	COG0670	Belongs to the BI1 family
RPIC12D_RS05770	COG0105	UTP biosynthetic process
RPIC12D_RS05775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RPIC12D_RS05790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RPIC12D_RS05795	COG0124	histidyl-tRNA synthetase
RPIC12D_RS05800	COG2976	Protein conserved in bacteria
RPIC12D_RS05810	COG1160	GTP binding
RPIC12D_RS05815	COG1923	regulation of RNA biosynthetic process
RPIC12D_RS05820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RPIC12D_RS05825	COG0330	HflC and HflK could
RPIC12D_RS05830	COG0330	HflC and HflK could
RPIC12D_RS05840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RPIC12D_RS05845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RPIC12D_RS05850	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RPIC12D_RS05860	COG0557	exoribonuclease II activity
RPIC12D_RS05865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIC12D_RS05870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RPIC12D_RS05875	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIC12D_RS05880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RPIC12D_RS05885	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RPIC12D_RS05890	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIC12D_RS05890	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RPIC12D_RS05895	COG1643	Atp-dependent helicase
RPIC12D_RS05920	COG1546	Belongs to the CinA family
RPIC12D_RS05920	COG1058	Belongs to the CinA family
RPIC12D_RS05930	COG0174	glutamine synthetase
RPIC12D_RS05945	COG2204	response regulator
RPIC12D_RS05960	COG1653	transport
RPIC12D_RS05965	COG1175	transmembrane transport
RPIC12D_RS05975	COG3842	ATPase activity
RPIC12D_RS05980	COG0584	glycerophosphoryl diester phosphodiesterase
RPIC12D_RS05985	COG0567	Dehydrogenase, E1 component
RPIC12D_RS05990	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC12D_RS05995	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC12D_RS06000	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RPIC12D_RS06010	COG2217	Heavy metal translocating P-type atpase
RPIC12D_RS06020	COG3278	Belongs to the heme-copper respiratory oxidase family
RPIC12D_RS06040	COG0348	domain, Protein
RPIC12D_RS06055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC12D_RS06065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RPIC12D_RS06075	COG0779	Required for maturation of 30S ribosomal subunits
RPIC12D_RS06080	COG0195	Participates in both transcription termination and antitermination
RPIC12D_RS06080	COG2251	uridine kinase activity
RPIC12D_RS06085	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RPIC12D_RS06090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RPIC12D_RS06095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RPIC12D_RS06100	COG2814	Major facilitator Superfamily
RPIC12D_RS06105	COG1566	PFAM secretion protein HlyD family protein
RPIC12D_RS06115	COG1846	Transcriptional regulator
RPIC12D_RS06120	COG1217	gtp-binding protein TYPA
RPIC12D_RS06130	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06140	COG1024	Enoyl-CoA hydratase
RPIC12D_RS06185	COG3706	GGDEF domain
RPIC12D_RS06190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RPIC12D_RS06200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RPIC12D_RS06215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC12D_RS06230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPIC12D_RS06245	COG0360	Binds together with S18 to 16S ribosomal RNA
RPIC12D_RS06255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RPIC12D_RS06260	COG0359	binds to the 23S rRNA
RPIC12D_RS06265	COG0305	Participates in initiation and elongation during chromosome replication
RPIC12D_RS06275	COG0306	phosphate transporter
RPIC12D_RS06280	COG0791	NLP P60 protein
RPIC12D_RS06290	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RPIC12D_RS06295	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RPIC12D_RS06305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC12D_RS06305	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIC12D_RS06320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIC12D_RS06325	COG2076	Multidrug Resistance protein
RPIC12D_RS06330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RPIC12D_RS06340	COG0436	Aminotransferase
RPIC12D_RS06355	COG1573	uracil-dna glycosylase
RPIC12D_RS06360	COG0303	'Molybdopterin
RPIC12D_RS06365	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RPIC12D_RS06370	COG0314	molybdopterin synthase activity
RPIC12D_RS06375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIC12D_RS06385	COG0542	response to heat
RPIC12D_RS06390	COG3328	transposase activity
RPIC12D_RS06400	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RPIC12D_RS06405	COG0431	NADPH-dependent FMN reductase
RPIC12D_RS06410	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC12D_RS06415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC12D_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC12D_RS06425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC12D_RS06430	COG1116	anion transmembrane transporter activity
RPIC12D_RS06450	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RPIC12D_RS06455	COG4208	sulfate ABC transporter
RPIC12D_RS06460	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RPIC12D_RS06465	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06475	COG2972	Histidine kinase
RPIC12D_RS06490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RPIC12D_RS06505	COG2224	Isocitrate lyase
RPIC12D_RS06520	COG1953	Uracil, thiamine, allantoin
RPIC12D_RS06530	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06540	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RPIC12D_RS06550	COG2814	Major facilitator Superfamily
RPIC12D_RS06560	COG1214	PFAM Peptidase M22, glycoprotease
RPIC12D_RS06565	COG0456	acetyltransferase
RPIC12D_RS06570	COG1573	uracil-dna glycosylase
RPIC12D_RS06575	COG0477	Major facilitator Superfamily
RPIC12D_RS06580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RPIC12D_RS06590	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RPIC12D_RS06595	COG1683	Conserved Protein
RPIC12D_RS06605	COG0488	(ABC) transporter
RPIC12D_RS06620	COG4172	Belongs to the ABC transporter superfamily
RPIC12D_RS06625	COG0747	negative chemotaxis
RPIC12D_RS06635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIC12D_RS06655	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIC12D_RS06665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC12D_RS06670	COG1393	Belongs to the ArsC family
RPIC12D_RS06680	COG2171	N-acyltransferase activity
RPIC12D_RS06695	COG0596	Alpha beta hydrolase
RPIC12D_RS06710	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RPIC12D_RS06715	COG0242	peptide deformylase activity
RPIC12D_RS06725	COG1187	pseudouridine synthase activity
RPIC12D_RS06730	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RPIC12D_RS06735	COG0024	Methionine aminopeptidase
RPIC12D_RS06740	COG0052	Belongs to the universal ribosomal protein uS2 family
RPIC12D_RS06745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RPIC12D_RS06750	COG0528	UMP kinase activity
RPIC12D_RS06755	COG0233	cytoplasmic translational termination
RPIC12D_RS06760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIC12D_RS06765	COG0575	Belongs to the CDS family
RPIC12D_RS06770	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RPIC12D_RS06775	COG0750	zinc metalloprotease
RPIC12D_RS06790	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC12D_RS06795	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPIC12D_RS06800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC12D_RS06805	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC12D_RS06810	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RPIC12D_RS06815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIC12D_RS06835	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RPIC12D_RS06850	COG0330	HflC and HflK could
RPIC12D_RS06855	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RPIC12D_RS06860	COG2867	negative regulation of translational initiation
RPIC12D_RS06865	COG2914	Belongs to the UPF0125 (RnfH) family
RPIC12D_RS06875	COG0697	spore germination
RPIC12D_RS06890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPIC12D_RS06890	COG0519	Catalyzes the synthesis of GMP from XMP
RPIC12D_RS06900	COG1278	Cold shock
RPIC12D_RS06930	COG1823	symporter activity
RPIC12D_RS06935	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06940	COG3485	protocatechuate 3,4-dioxygenase
RPIC12D_RS06945	COG3485	protocatechuate 3,4-dioxygenase
RPIC12D_RS06965	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06985	COG0583	DNA-binding transcription factor activity
RPIC12D_RS06995	COG0602	queuosine metabolic process
RPIC12D_RS07000	COG0720	synthase
RPIC12D_RS07010	COG1619	proteins homologs of microcin C7 resistance protein MccF
RPIC12D_RS07015	COG0488	(ABC) transporter
RPIC12D_RS07025	COG0427	acetyl-CoA hydrolase
RPIC12D_RS07030	COG0583	DNA-binding transcription factor activity
RPIC12D_RS07050	COG3387	PFAM Glycoside hydrolase 15-related
RPIC12D_RS07060	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RPIC12D_RS07065	COG0840	transmembrane signaling receptor activity
RPIC12D_RS07085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RPIC12D_RS07120	COG3045	CreA protein
RPIC12D_RS07125	COG0583	DNA-binding transcription factor activity
RPIC12D_RS07140	COG0583	DNA-binding transcription factor activity
RPIC12D_RS07145	COG4948	Mandelate Racemase Muconate Lactonizing
RPIC12D_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS07180	COG2814	Major facilitator Superfamily
RPIC12D_RS07185	COG3135	benzoate transporter
RPIC12D_RS07195	COG0156	8-amino-7-oxononanoate synthase activity
RPIC12D_RS07200	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RPIC12D_RS07225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIC12D_RS07235	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC12D_RS07240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIC12D_RS07245	COG0066	3-isopropylmalate dehydratase activity
RPIC12D_RS07250	COG2814	Major facilitator Superfamily
RPIC12D_RS07280	COG1473	amidohydrolase
RPIC12D_RS07285	COG0154	amidase activity
RPIC12D_RS07300	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RPIC12D_RS07305	COG3842	ATPase activity
RPIC12D_RS07310	COG4208	sulfate ABC transporter
RPIC12D_RS07315	COG1176	ABC-type spermidine putrescine transport system, permease component I
RPIC12D_RS07320	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIC12D_RS07325	COG1609	Transcriptional regulator
RPIC12D_RS07330	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPIC12D_RS07340	COG0084	hydrolase, TatD family'
RPIC12D_RS07350	COG0470	DNA polymerase III
RPIC12D_RS07355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RPIC12D_RS07360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RPIC12D_RS07400	COG0657	acetylesterase activity
RPIC12D_RS07410	COG0596	Alpha beta hydrolase
RPIC12D_RS07430	COG2130	NADP-dependent
RPIC12D_RS07450	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS07455	COG0183	Belongs to the thiolase family
RPIC12D_RS07460	COG1335	isochorismatase
RPIC12D_RS07465	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS07465	COG1024	Enoyl-CoA hydratase
RPIC12D_RS07470	COG0833	amino acid
RPIC12D_RS07475	COG0833	amino acid
RPIC12D_RS07495	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPIC12D_RS07505	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS07510	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RPIC12D_RS07515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIC12D_RS07520	COG2917	probably involved in intracellular septation
RPIC12D_RS07530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC12D_RS07545	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RPIC12D_RS07555	COG4682	membrane
RPIC12D_RS07615	COG3842	ATPase activity
RPIC12D_RS07625	COG1176	ABC-type spermidine putrescine transport system, permease component I
RPIC12D_RS07630	COG1177	transmembrane transport
RPIC12D_RS07640	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS07645	COG0583	DNA-binding transcription factor activity
RPIC12D_RS07655	COG0047	phosphoribosylformylglycinamidine synthase activity
RPIC12D_RS07655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIC12D_RS07665	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RPIC12D_RS07665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RPIC12D_RS07670	COG0166	Belongs to the GPI family
RPIC12D_RS07675	COG4181	ATPase activity
RPIC12D_RS07685	COG0681	Belongs to the peptidase S26 family
RPIC12D_RS07690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC12D_RS07705	COG0776	regulation of translation
RPIC12D_RS07710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC12D_RS07715	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RPIC12D_RS07720	COG0740	serine-type endopeptidase activity
RPIC12D_RS07725	COG0544	peptidyl-prolyl cis-trans isomerase activity
RPIC12D_RS07730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RPIC12D_RS07730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC12D_RS07740	COG0477	Major facilitator Superfamily
RPIC12D_RS07745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC12D_RS07750	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS07755	COG0583	DNA-binding transcription factor activity
RPIC12D_RS07765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RPIC12D_RS07770	COG1845	cytochrome c oxidase, subunit III
RPIC12D_RS07775	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIC12D_RS07780	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPIC12D_RS07785	COG0477	Major facilitator Superfamily
RPIC12D_RS07800	COG3473	Maleate cis-trans isomerase
RPIC12D_RS07835	COG1730	sister chromatid segregation
RPIC12D_RS07840	COG1858	cytochrome C peroxidase
RPIC12D_RS07860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC12D_RS07895	COG0450	alkyl hydroperoxide reductase
RPIC12D_RS07900	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS07905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RPIC12D_RS07910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RPIC12D_RS07915	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RPIC12D_RS07925	COG0560	Phosphoserine phosphatase
RPIC12D_RS07930	COG4804	nuclease activity
RPIC12D_RS07935	COG0626	cystathionine gamma-synthase activity
RPIC12D_RS07945	COG0183	Belongs to the thiolase family
RPIC12D_RS07950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIC12D_RS07955	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RPIC12D_RS07965	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS07970	COG0183	Belongs to the thiolase family
RPIC12D_RS07975	COG3243	poly(R)-hydroxyalkanoic acid synthase
RPIC12D_RS07990	COG0564	pseudouridine synthase activity
RPIC12D_RS08000	COG1199	ATP-dependent helicase activity
RPIC12D_RS08015	COG2183	response to ionizing radiation
RPIC12D_RS08025	COG3158	transport of potassium into the cell
RPIC12D_RS08035	COG0167	dihydroorotate dehydrogenase activity
RPIC12D_RS08055	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RPIC12D_RS08060	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RPIC12D_RS08075	COG1139	Iron-sulfur cluster binding protein
RPIC12D_RS08080	COG0247	lactate metabolic process
RPIC12D_RS08085	COG1414	Transcriptional regulator
RPIC12D_RS08100	COG0824	Thioesterase
RPIC12D_RS08110	COG0123	including yeast histone deacetylase and acetoin utilization protein
RPIC12D_RS08125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC12D_RS08135	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC12D_RS08140	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RPIC12D_RS08150	COG4566	intracellular signal transduction
RPIC12D_RS08155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RPIC12D_RS08160	COG0339	signal peptide processing
RPIC12D_RS08180	COG3971	2-oxopent-4-enoate hydratase activity
RPIC12D_RS08190	COG3384	dioxygenase
RPIC12D_RS08195	COG1012	belongs to the aldehyde dehydrogenase family
RPIC12D_RS08215	COG0531	amino acid
RPIC12D_RS08220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIC12D_RS08235	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS08240	COG2207	Transcriptional regulator
RPIC12D_RS08255	COG0776	regulation of translation
RPIC12D_RS08260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC12D_RS08260	COG0072	phenylalanine-tRNA ligase activity
RPIC12D_RS08265	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RPIC12D_RS08270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RPIC12D_RS08275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RPIC12D_RS08280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RPIC12D_RS08285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RPIC12D_RS08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIC12D_RS08300	COG0251	oxidation-reduction process
RPIC12D_RS08310	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS08325	COG4566	intracellular signal transduction
RPIC12D_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS08340	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RPIC12D_RS08345	COG0545	Peptidyl-prolyl cis-trans isomerase
RPIC12D_RS08350	COG0477	Major facilitator Superfamily
RPIC12D_RS08365	COG0596	Alpha beta hydrolase
RPIC12D_RS08365	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC12D_RS08375	COG1295	ribonuclease BN
RPIC12D_RS08390	COG0277	FAD linked oxidase domain protein
RPIC12D_RS08530	COG1522	sequence-specific DNA binding
RPIC12D_RS08540	COG1522	sequence-specific DNA binding
RPIC12D_RS08545	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RPIC12D_RS08555	COG0656	L-ascorbic acid biosynthetic process
RPIC12D_RS08560	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIC12D_RS08560	COG1902	pentaerythritol trinitrate reductase activity
RPIC12D_RS08575	COG1279	arginine transmembrane transporter activity
RPIC12D_RS08580	COG0583	DNA-binding transcription factor activity
RPIC12D_RS08590	COG0640	Transcriptional regulator
RPIC12D_RS08595	COG0730	response to heat
RPIC12D_RS08615	COG0248	Ppx GppA phosphatase
RPIC12D_RS08620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RPIC12D_RS08630	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS08640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIC12D_RS08645	COG0581	inorganic phosphate transmembrane transporter activity
RPIC12D_RS08650	COG0573	inorganic phosphate transmembrane transporter activity
RPIC12D_RS08655	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RPIC12D_RS08660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIC12D_RS08665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIC12D_RS08670	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC12D_RS08675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RPIC12D_RS08680	COG1534	Rna-binding protein
RPIC12D_RS08690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIC12D_RS08695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RPIC12D_RS08705	COG0505	Belongs to the CarA family
RPIC12D_RS08710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIC12D_RS08715	COG0741	lytic transglycosylase activity
RPIC12D_RS08715	COG1388	LysM domain
RPIC12D_RS08720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC12D_RS08725	COG2226	methyltransferase
RPIC12D_RS08730	COG0328	RNA-DNA hybrid ribonuclease activity
RPIC12D_RS08740	COG3772	lysozyme
RPIC12D_RS08755	COG2197	response regulator
RPIC12D_RS08765	COG2719	SpoVR family
RPIC12D_RS08770	COG2718	Belongs to the UPF0229 family
RPIC12D_RS08775	COG2766	serine protein kinase
RPIC12D_RS08780	COG0583	DNA-binding transcription factor activity
RPIC12D_RS08805	COG1024	Enoyl-CoA hydratase
RPIC12D_RS08805	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS08820	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RPIC12D_RS08860	COG2072	flavoprotein involved in K transport
RPIC12D_RS08865	COG0601	transmembrane transport
RPIC12D_RS08870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIC12D_RS08875	COG0444	Belongs to the ABC transporter superfamily
RPIC12D_RS08880	COG4608	Belongs to the ABC transporter superfamily
RPIC12D_RS08885	COG0747	negative chemotaxis
RPIC12D_RS08925	COG0840	transmembrane signaling receptor activity
RPIC12D_RS08940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIC12D_RS08945	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIC12D_RS08950	COG0697	spore germination
RPIC12D_RS08965	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RPIC12D_RS08970	COG1301	dicarboxylic acid transport
RPIC12D_RS08995	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC12D_RS09005	COG3154	lipid carrier protein
RPIC12D_RS09010	COG0826	peptidase U32
RPIC12D_RS09015	COG0826	peptidase U32
RPIC12D_RS09025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC12D_RS09050	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RPIC12D_RS09085	COG1131	(ABC) transporter
RPIC12D_RS09090	COG0842	Transport permease protein
RPIC12D_RS09095	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RPIC12D_RS09110	COG0285	dihydrofolate synthase activity
RPIC12D_RS09115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RPIC12D_RS09120	COG0159	tryptophan synthase activity
RPIC12D_RS09130	COG0133	tryptophan synthase activity
RPIC12D_RS09135	COG0135	phosphoribosylanthranilate isomerase activity
RPIC12D_RS09140	COG0101	tRNA pseudouridine synthase activity
RPIC12D_RS09155	COG0473	3-isopropylmalate dehydrogenase activity
RPIC12D_RS09160	COG0066	3-isopropylmalate dehydratase activity
RPIC12D_RS09165	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIC12D_RS09170	COG0372	Belongs to the citrate synthase family
RPIC12D_RS09175	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RPIC12D_RS09180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RPIC12D_RS09185	COG1053	succinate dehydrogenase
RPIC12D_RS09190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RPIC12D_RS09200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC12D_RS09205	COG0039	L-malate dehydrogenase activity
RPIC12D_RS09230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RPIC12D_RS09255	COG2866	Carboxypeptidase
RPIC12D_RS09260	COG3022	response to hydroperoxide
RPIC12D_RS09270	COG0436	Aminotransferase
RPIC12D_RS09275	COG0625	glutathione transferase activity
RPIC12D_RS09280	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS09285	COG1024	Enoyl-CoA hydratase
RPIC12D_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS09310	COG0583	DNA-binding transcription factor activity
RPIC12D_RS09330	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS09335	COG0625	glutathione transferase activity
RPIC12D_RS09350	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RPIC12D_RS09355	COG0830	nickel cation binding
RPIC12D_RS09360	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RPIC12D_RS09370	COG0804	urea catabolic process
RPIC12D_RS09375	COG0832	Belongs to the urease beta subunit family
RPIC12D_RS09385	COG0831	urea catabolic process
RPIC12D_RS09390	COG0829	nickel cation binding
RPIC12D_RS09400	COG0411	ABC transporter
RPIC12D_RS09425	COG1012	belongs to the aldehyde dehydrogenase family
RPIC12D_RS09425	COG2030	dehydratase
RPIC12D_RS09430	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS09435	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS09445	COG0494	nUDIX hydrolase
RPIC12D_RS09455	COG1007	ATP synthesis coupled electron transport
RPIC12D_RS09470	COG0713	ATP synthesis coupled electron transport
RPIC12D_RS09480	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC12D_RS09485	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPIC12D_RS09490	COG1034	ATP synthesis coupled electron transport
RPIC12D_RS09505	COG0649	NAD binding
RPIC12D_RS09510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC12D_RS09515	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC12D_RS09520	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC12D_RS09535	COG0149	triose-phosphate isomerase activity
RPIC12D_RS09550	COG1185	polyribonucleotide nucleotidyltransferase activity
RPIC12D_RS09555	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RPIC12D_RS09560	COG0683	leucine binding
RPIC12D_RS09570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIC12D_RS09575	COG1183	phosphatidylcholine synthase activity
RPIC12D_RS09580	COG0688	phosphatidylethanolamine metabolic process
RPIC12D_RS09585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RPIC12D_RS09590	COG0440	acetolactate synthase activity
RPIC12D_RS09595	COG0028	Belongs to the TPP enzyme family
RPIC12D_RS09630	COG0438	transferase activity, transferring glycosyl groups
RPIC12D_RS09640	COG1309	transcriptional regulator
RPIC12D_RS09660	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RPIC12D_RS09685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RPIC12D_RS09695	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIC12D_RS09700	COG0402	S-adenosylhomocysteine deaminase activity
RPIC12D_RS09705	COG2119	membrane
RPIC12D_RS09735	COG2351	hydroxyisourate hydrolase activity
RPIC12D_RS09745	COG2233	PERMEase
RPIC12D_RS09770	COG0280	phosphate acetyltransferase
RPIC12D_RS09770	COG0281	malic enzyme
RPIC12D_RS09780	COG0308	aminopeptidase N
RPIC12D_RS09785	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RPIC12D_RS09795	COG1652	LysM domain
RPIC12D_RS09815	COG0583	DNA-binding transcription factor activity
RPIC12D_RS09845	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIC12D_RS09855	COG1758	RNA polymerase activity
RPIC12D_RS09860	COG0194	GDP metabolic process
RPIC12D_RS09865	COG1561	YicC-like family, N-terminal region
RPIC12D_RS09870	COG0515	serine threonine protein kinase
RPIC12D_RS09870	COG3064	Membrane
RPIC12D_RS09870	COG4991	sh3 domain protein
RPIC12D_RS09880	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RPIC12D_RS09885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RPIC12D_RS09890	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPIC12D_RS09925	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RPIC12D_RS09945	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RPIC12D_RS09950	COG1984	allophanate hydrolase subunit 2
RPIC12D_RS09955	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RPIC12D_RS09960	COG2814	Major facilitator Superfamily
RPIC12D_RS09965	COG3845	ABC transporter
RPIC12D_RS09970	COG4603	Belongs to the binding-protein-dependent transport system permease family
RPIC12D_RS09975	COG1079	Belongs to the binding-protein-dependent transport system permease family
RPIC12D_RS09995	COG1803	Methylglyoxal synthase
RPIC12D_RS10000	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS10005	COG0697	spore germination
RPIC12D_RS10010	COG1953	Uracil, thiamine, allantoin
RPIC12D_RS10015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RPIC12D_RS10020	COG0433	COG0433 Predicted ATPase
RPIC12D_RS10025	COG0217	transcriptional regulatory protein
RPIC12D_RS10030	COG0151	Belongs to the GarS family
RPIC12D_RS10035	COG0408	coproporphyrinogen oxidase activity
RPIC12D_RS10040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RPIC12D_RS10045	COG0799	negative regulation of ribosome biogenesis
RPIC12D_RS10050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RPIC12D_RS10055	COG0424	maF-like protein
RPIC12D_RS10060	COG1530	ribonuclease E activity
RPIC12D_RS10065	COG2271	Major facilitator Superfamily
RPIC12D_RS10075	COG1012	belongs to the aldehyde dehydrogenase family
RPIC12D_RS10095	COG1132	(ABC) transporter
RPIC12D_RS10130	COG1054	Belongs to the UPF0176 family
RPIC12D_RS10140	COG1741	Belongs to the pirin family
RPIC12D_RS10145	COG0583	DNA-binding transcription factor activity
RPIC12D_RS10150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC12D_RS10155	COG0513	Belongs to the DEAD box helicase family
RPIC12D_RS10160	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RPIC12D_RS10160	COG0426	domain, Protein
RPIC12D_RS10175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RPIC12D_RS10180	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RPIC12D_RS10190	COG3047	cAMP biosynthetic process
RPIC12D_RS10225	COG2081	HI0933 family
RPIC12D_RS10230	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RPIC12D_RS10235	COG1469	GTP cyclohydrolase I activity
RPIC12D_RS10240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPIC12D_RS10245	COG0142	geranyltranstransferase activity
RPIC12D_RS10250	COG1722	exodeoxyribonuclease VII activity
RPIC12D_RS10275	COG0412	Dienelactone hydrolase
RPIC12D_RS10280	COG1252	NADH dehydrogenase
RPIC12D_RS10285	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIC12D_RS10285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIC12D_RS10290	COG1611	Belongs to the LOG family
RPIC12D_RS10300	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RPIC12D_RS10310	COG0210	DNA helicase
RPIC12D_RS10315	COG0525	valine-tRNA ligase activity
RPIC12D_RS10320	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RPIC12D_RS10330	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RPIC12D_RS10340	COG2342	PFAM TM1410 hypothetical-related protein
RPIC12D_RS10355	COG0683	leucine binding
RPIC12D_RS10365	COG0411	ABC transporter
RPIC12D_RS10380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS10385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIC12D_RS10395	COG0183	Belongs to the thiolase family
RPIC12D_RS10400	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RPIC12D_RS10410	COG1414	Transcriptional regulator
RPIC12D_RS10420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC12D_RS10425	COG0765	amino acid transport
RPIC12D_RS10430	COG0765	amino acid transport
RPIC12D_RS10445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC12D_RS10485	COG1253	flavin adenine dinucleotide binding
RPIC12D_RS10490	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS10495	COG0789	Transcriptional regulator
RPIC12D_RS10535	COG3284	Transcriptional regulator
RPIC12D_RS10550	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RPIC12D_RS10555	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RPIC12D_RS10570	COG4654	Cytochrome c, class I
RPIC12D_RS10620	COG0204	Acyl-transferase
RPIC12D_RS10650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC12D_RS10660	COG0346	lactoylglutathione lyase activity
RPIC12D_RS10680	COG4654	Cytochrome c, class I
RPIC12D_RS10705	COG1999	signal sequence binding
RPIC12D_RS10770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIC12D_RS10780	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RPIC12D_RS10785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RPIC12D_RS10790	COG0477	Major facilitator Superfamily
RPIC12D_RS10810	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RPIC12D_RS10815	COG1674	ftsk spoiiie
RPIC12D_RS10820	COG0492	ferredoxin-NADP+ reductase activity
RPIC12D_RS10825	COG1193	negative regulation of DNA recombination
RPIC12D_RS10835	COG0347	Belongs to the P(II) protein family
RPIC12D_RS10860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RPIC12D_RS10875	COG2271	Major facilitator Superfamily
RPIC12D_RS10890	COG0181	hydroxymethylbilane synthase activity
RPIC12D_RS10895	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RPIC12D_RS10925	COG0165	Argininosuccinate lyase
RPIC12D_RS10935	COG0717	Belongs to the dCTP deaminase family
RPIC12D_RS10940	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RPIC12D_RS10945	COG2032	superoxide dismutase activity
RPIC12D_RS10965	COG0437	4 iron, 4 sulfur cluster binding
RPIC12D_RS10970	COG0243	molybdopterin cofactor binding
RPIC12D_RS10970	COG3383	formate dehydrogenase (NAD+) activity
RPIC12D_RS11000	COG0489	protein tyrosine kinase activity
RPIC12D_RS11005	COG3047	cAMP biosynthetic process
RPIC12D_RS11005	COG2885	chlorophyll binding
RPIC12D_RS11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC12D_RS11010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC12D_RS11020	COG2911	Protein conserved in bacteria
RPIC12D_RS11025	COG0729	surface antigen
RPIC12D_RS11035	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RPIC12D_RS11040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RPIC12D_RS11050	COG1492	cobalamin metabolic process
RPIC12D_RS11080	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RPIC12D_RS11085	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RPIC12D_RS11095	COG1120	ATPase activity
RPIC12D_RS11105	COG4206	TonB-dependent receptor
RPIC12D_RS11130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RPIC12D_RS11135	COG0583	DNA-binding transcription factor activity
RPIC12D_RS11140	COG0129	dihydroxy-acid dehydratase activity
RPIC12D_RS11155	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPIC12D_RS11185	COG2895	sulfate adenylyltransferase (ATP) activity
RPIC12D_RS11195	COG0175	sulfate reduction
RPIC12D_RS11205	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIC12D_RS11210	COG0730	response to heat
RPIC12D_RS11215	COG0583	DNA-binding transcription factor activity
RPIC12D_RS11225	COG2084	Dehydrogenase
RPIC12D_RS11235	COG0582	viral genome integration into host DNA
RPIC12D_RS11255	COG3179	chitinase
RPIC12D_RS11375	COG3566	protein conserved in bacteria
RPIC12D_RS11390	COG5410	chromosome segregation
RPIC12D_RS11565	COG0656	L-ascorbic acid biosynthetic process
RPIC12D_RS11570	COG2814	Major facilitator Superfamily
RPIC12D_RS11600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIC12D_RS11635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPIC12D_RS11640	COG1047	Peptidyl-prolyl cis-trans
RPIC12D_RS11645	COG2003	Belongs to the UPF0758 family
RPIC12D_RS11650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RPIC12D_RS11655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RPIC12D_RS11660	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RPIC12D_RS11670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RPIC12D_RS11680	COG3264	Mechanosensitive ion channel
RPIC12D_RS11680	COG1511	domain protein
RPIC12D_RS11685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIC12D_RS11690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIC12D_RS11690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RPIC12D_RS11695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RPIC12D_RS11710	COG0196	riboflavin kinase activity
RPIC12D_RS11715	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RPIC12D_RS11720	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RPIC12D_RS11730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RPIC12D_RS11735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC12D_RS11740	COG0756	dUTP diphosphatase activity
RPIC12D_RS11745	COG0542	response to heat
RPIC12D_RS11750	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPIC12D_RS11755	COG1278	Cold shock
RPIC12D_RS11785	COG1858	cytochrome C peroxidase
RPIC12D_RS11800	COG3895	Periplasmic Protein
RPIC12D_RS11805	COG0583	DNA-binding transcription factor activity
RPIC12D_RS11820	COG2259	Doxx family
RPIC12D_RS11845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC12D_RS11855	COG2321	neutral zinc metallopeptidase
RPIC12D_RS11860	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS11870	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC12D_RS11930	COG2610	gluconate transmembrane transporter activity
RPIC12D_RS11960	COG0010	Belongs to the arginase family
RPIC12D_RS11965	COG1126	abc transporter atp-binding protein
RPIC12D_RS11970	COG0765	amino acid transport
RPIC12D_RS11975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC12D_RS12010	COG1570	exodeoxyribonuclease VII activity
RPIC12D_RS12015	COG0811	peptide transport
RPIC12D_RS12025	COG1663	tetraacyldisaccharide 4'-kinase activity
RPIC12D_RS12030	COG2835	tetraacyldisaccharide 4'-kinase activity
RPIC12D_RS12035	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RPIC12D_RS12040	COG0563	adenylate kinase activity
RPIC12D_RS12050	COG0583	DNA-binding transcription factor activity
RPIC12D_RS12065	COG0860	N-Acetylmuramoyl-L-alanine amidase
RPIC12D_RS12070	COG0802	atpase or kinase
RPIC12D_RS12075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RPIC12D_RS12085	COG3181	Tripartite tricarboxylate transporter family receptor
RPIC12D_RS12090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC12D_RS12095	COG4974	Belongs to the 'phage' integrase family
RPIC12D_RS12100	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RPIC12D_RS12105	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RPIC12D_RS12115	COG2366	antibiotic biosynthetic process
RPIC12D_RS12120	COG1666	GTP binding
RPIC12D_RS12125	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RPIC12D_RS12130	COG3123	guanosine phosphorylase activity
RPIC12D_RS12135	COG0137	argininosuccinate synthase activity
RPIC12D_RS12140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RPIC12D_RS12150	COG0268	Binds directly to 16S ribosomal RNA
RPIC12D_RS12155	COG0728	peptidoglycan biosynthetic process
RPIC12D_RS12165	COG0586	Pfam SNARE associated Golgi protein
RPIC12D_RS12170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RPIC12D_RS12175	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RPIC12D_RS12180	COG0456	acetyltransferase
RPIC12D_RS12200	COG4459	periplasmic nitrate reductase
RPIC12D_RS12210	COG0243	molybdopterin cofactor binding
RPIC12D_RS12215	COG3043	anaerobic respiration
RPIC12D_RS12220	COG3005	denitrification pathway
RPIC12D_RS12225	COG4133	protoheme IX ABC transporter activity
RPIC12D_RS12240	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RPIC12D_RS12250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIC12D_RS12265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC12D_RS12265	COG2169	Transcriptional regulator
RPIC12D_RS12280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RPIC12D_RS12285	COG0628	permease
RPIC12D_RS12305	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RPIC12D_RS12315	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RPIC12D_RS12320	COG4662	Binding-protein-dependent transport system inner membrane component
RPIC12D_RS12325	COG3842	ATPase activity
RPIC12D_RS12330	COG0512	Glutamine amidotransferase of anthranilate synthase
RPIC12D_RS12330	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RPIC12D_RS12335	COG0484	heat shock protein binding
RPIC12D_RS12340	COG0443	Heat shock 70 kDa protein
RPIC12D_RS12350	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIC12D_RS12360	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPIC12D_RS12375	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RPIC12D_RS12380	COG1228	amidohydrolase
RPIC12D_RS12385	COG0010	Belongs to the arginase family
RPIC12D_RS12390	COG2986	histidine ammonia-lyase
RPIC12D_RS12395	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RPIC12D_RS12405	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC12D_RS12415	COG4521	taurine ABC transporter
RPIC12D_RS12420	COG1420	regulation of RNA biosynthetic process
RPIC12D_RS12425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RPIC12D_RS12430	COG0497	DNA recombination
RPIC12D_RS12440	COG1404	Belongs to the peptidase S8 family
RPIC12D_RS12445	COG1404	Belongs to the peptidase S8 family
RPIC12D_RS12455	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RPIC12D_RS12465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RPIC12D_RS12470	COG0312	modulator of DNA gyrase
RPIC12D_RS12475	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RPIC12D_RS12480	COG0668	transmembrane transport
RPIC12D_RS12485	COG2096	Adenosyltransferase
RPIC12D_RS12490	COG0277	FAD linked oxidase domain protein
RPIC12D_RS12495	COG0583	DNA-binding transcription factor activity
RPIC12D_RS12500	COG0277	FAD linked oxidase domain protein
RPIC12D_RS12505	COG0277	FAD linked oxidase domain protein
RPIC12D_RS12510	COG0247	lactate metabolic process
RPIC12D_RS12515	COG1380	Effector of murein hydrolase LrgA
RPIC12D_RS12520	COG1346	cytolysis
RPIC12D_RS12540	COG0386	Belongs to the glutathione peroxidase family
RPIC12D_RS12565	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RPIC12D_RS12570	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RPIC12D_RS12575	COG0783	Belongs to the Dps family
RPIC12D_RS12585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC12D_RS12605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPIC12D_RS12655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RPIC12D_RS12665	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS12675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC12D_RS12715	COG1230	cation diffusion facilitator family transporter
RPIC12D_RS12735	COG1408	metallophosphoesterase
RPIC12D_RS12745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RPIC12D_RS12750	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RPIC12D_RS12755	COG0343	queuine tRNA-ribosyltransferase activity
RPIC12D_RS12760	COG1862	Preprotein translocase
RPIC12D_RS12780	COG2353	YceI-like domain
RPIC12D_RS12785	COG3038	cytochrome b561
RPIC12D_RS12795	COG0625	glutathione transferase activity
RPIC12D_RS12800	COG0069	glutamate synthase activity
RPIC12D_RS12805	COG0482	sulfurtransferase activity
RPIC12D_RS12820	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RPIC12D_RS12845	COG4191	Histidine kinase
RPIC12D_RS12850	COG4191	Histidine kinase
RPIC12D_RS12855	COG2204	response regulator
RPIC12D_RS12865	COG1981	membrane
RPIC12D_RS12870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RPIC12D_RS12885	COG0495	leucyl-tRNA aminoacylation
RPIC12D_RS12890	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RPIC12D_RS12895	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RPIC12D_RS12900	COG0735	belongs to the Fur family
RPIC12D_RS12905	COG0583	DNA-binding transcription factor activity
RPIC12D_RS12910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RPIC12D_RS12915	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RPIC12D_RS12920	COG4948	Mandelate Racemase Muconate Lactonizing
RPIC12D_RS12925	COG0800	Aldolase
RPIC12D_RS12930	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS12945	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIC12D_RS12950	COG1129	ABC transporter
RPIC12D_RS12965	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS12970	COG0583	DNA-binding transcription factor activity
RPIC12D_RS12980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RPIC12D_RS13045	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RPIC12D_RS13050	COG1058	Belongs to the CinA family
RPIC12D_RS13050	COG1546	Belongs to the CinA family
RPIC12D_RS13060	COG0284	orotidine-5'-phosphate decarboxylase activity
RPIC12D_RS13070	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RPIC12D_RS13075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RPIC12D_RS13085	COG0557	exoribonuclease II activity
RPIC12D_RS13090	COG3161	chorismate lyase activity
RPIC12D_RS13095	COG3150	esterase
RPIC12D_RS13100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIC12D_RS13110	COG3118	belongs to the thioredoxin family
RPIC12D_RS13115	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RPIC12D_RS13120	COG0511	ligase activity, forming carbon-carbon bonds
RPIC12D_RS13130	COG2264	protein methyltransferase activity
RPIC12D_RS13140	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RPIC12D_RS13145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC12D_RS13180	COG0840	transmembrane signaling receptor activity
RPIC12D_RS13225	COG3023	N-Acetylmuramoyl-L-alanine amidase
RPIC12D_RS13250	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RPIC12D_RS13255	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RPIC12D_RS13260	COG2095	MarC family integral membrane protein
RPIC12D_RS13270	COG0741	lytic transglycosylase activity
RPIC12D_RS13275	COG0442	prolyl-tRNA aminoacylation
RPIC12D_RS13280	COG0494	nUDIX hydrolase
RPIC12D_RS13290	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RPIC12D_RS13295	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPIC12D_RS13300	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RPIC12D_RS13305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RPIC12D_RS13310	COG0142	geranyltranstransferase activity
RPIC12D_RS13320	COG0582	viral genome integration into host DNA
RPIC12D_RS13345	COG0210	DNA helicase
RPIC12D_RS13365	COG2433	Pfam Transposase IS66
RPIC12D_RS13370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RPIC12D_RS13375	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPIC12D_RS13380	COG1205	dead DEAH box helicase
RPIC12D_RS13380	COG1111	helicase
RPIC12D_RS13495	COG3620	sequence-specific DNA binding
RPIC12D_RS13525	COG4536	flavin adenine dinucleotide binding
RPIC12D_RS13540	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RPIC12D_RS13545	COG0237	dephospho-CoA kinase activity
RPIC12D_RS13550	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RPIC12D_RS13555	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RPIC12D_RS13560	COG0494	nUDIX hydrolase
RPIC12D_RS13570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RPIC12D_RS13575	COG0653	protein targeting
RPIC12D_RS13580	COG0739	heme binding
RPIC12D_RS13590	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RPIC12D_RS13595	COG0678	peroxiredoxin activity
RPIC12D_RS13610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RPIC12D_RS13615	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIC12D_RS13620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIC12D_RS13625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RPIC12D_RS13635	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RPIC12D_RS13640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIC12D_RS13645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RPIC12D_RS13650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RPIC12D_RS13660	COG3116	cell division
RPIC12D_RS13670	COG2001	Belongs to the MraZ family
RPIC12D_RS13675	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RPIC12D_RS13680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS13685	COG0477	Major facilitator Superfamily
RPIC12D_RS13690	COG1272	protein, Hemolysin III
RPIC12D_RS13695	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS13705	COG0243	molybdopterin cofactor binding
RPIC12D_RS13710	COG1609	Transcriptional regulator
RPIC12D_RS13715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC12D_RS13715	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIC12D_RS13720	COG1105	Belongs to the carbohydrate kinase PfkB family
RPIC12D_RS13725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RPIC12D_RS13725	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RPIC12D_RS13735	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC12D_RS13740	COG1473	amidohydrolase
RPIC12D_RS13770	COG1024	Enoyl-CoA hydratase
RPIC12D_RS13775	COG1024	Enoyl-CoA hydratase
RPIC12D_RS13780	COG2050	protein possibly involved in aromatic compounds catabolism
RPIC12D_RS13800	COG2967	ApaG domain
RPIC12D_RS13805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RPIC12D_RS13810	COG0546	phosphoglycolate phosphatase activity
RPIC12D_RS13820	COG0512	Glutamine amidotransferase of anthranilate synthase
RPIC12D_RS13830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIC12D_RS13835	COG0134	indole-3-glycerol-phosphate synthase activity
RPIC12D_RS13845	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RPIC12D_RS13850	COG1289	transmembrane transporter activity
RPIC12D_RS13860	COG0604	alcohol dehydrogenase
RPIC12D_RS13870	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPIC12D_RS13895	COG0012	GTP binding
RPIC12D_RS13940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS13985	COG4251	negative regulation of phosphorylation
RPIC12D_RS13990	COG0784	Response regulator, receiver
RPIC12D_RS13995	COG4999	Histidine kinase
RPIC12D_RS13995	COG2205	protein histidine kinase activity
RPIC12D_RS13995	COG3437	response regulator, receiver
RPIC12D_RS13995	COG3850	Histidine kinase
RPIC12D_RS14005	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RPIC12D_RS14010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RPIC12D_RS14020	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIC12D_RS14025	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RPIC12D_RS14045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RPIC12D_RS14050	COG2943	transferase activity, transferring hexosyl groups
RPIC12D_RS14050	COG3416	Protein conserved in bacteria
RPIC12D_RS14070	COG0488	(ABC) transporter
RPIC12D_RS14075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RPIC12D_RS14280	COG2969	positive regulation of protein catabolic process
RPIC12D_RS14285	COG0625	glutathione transferase activity
RPIC12D_RS14290	COG2857	Cytochrome c1
RPIC12D_RS14295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RPIC12D_RS14300	COG0723	plastoquinol--plastocyanin reductase activity
RPIC12D_RS14305	COG1970	mechanosensitive ion channel activity
RPIC12D_RS14310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RPIC12D_RS14315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC12D_RS14325	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS14340	COG0642	Histidine kinase
RPIC12D_RS14345	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIC12D_RS14355	COG3842	ATPase activity
RPIC12D_RS14360	COG0805	protein transport
RPIC12D_RS14365	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIC12D_RS14370	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIC12D_RS14380	COG0140	phosphoribosyl-ATP diphosphatase activity
RPIC12D_RS14385	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RPIC12D_RS14390	COG0107	imidazoleglycerol-phosphate synthase activity
RPIC12D_RS14395	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RPIC12D_RS14400	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RPIC12D_RS14405	COG2095	MarC family integral membrane protein
RPIC12D_RS14410	COG0131	Imidazoleglycerol-phosphate dehydratase
RPIC12D_RS14415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIC12D_RS14420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RPIC12D_RS14425	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RPIC12D_RS14430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RPIC12D_RS14440	COG0842	Transport permease protein
RPIC12D_RS14445	COG1131	(ABC) transporter
RPIC12D_RS14465	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPIC12D_RS14470	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RPIC12D_RS14475	COG1127	ABC transporter
RPIC12D_RS14490	COG0070	glutamate synthase
RPIC12D_RS14490	COG0069	glutamate synthase activity
RPIC12D_RS14490	COG0067	glutamate synthase
RPIC12D_RS14500	COG3047	cAMP biosynthetic process
RPIC12D_RS14505	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RPIC12D_RS14510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RPIC12D_RS14515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPIC12D_RS14550	COG1965	Belongs to the frataxin family
RPIC12D_RS14565	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RPIC12D_RS14570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIC12D_RS14590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIC12D_RS14595	COG1333	cytochrome c biogenesis protein
RPIC12D_RS14605	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RPIC12D_RS14615	COG4232	protein-disulfide reductase activity
RPIC12D_RS14625	COG0203	ribosomal protein L17
RPIC12D_RS14630	COG0202	RNA polymerase activity
RPIC12D_RS14635	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RPIC12D_RS14640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RPIC12D_RS14645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPIC12D_RS14650	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RPIC12D_RS14660	COG0201	protein transport
RPIC12D_RS14665	COG0200	Binds to the 23S rRNA
RPIC12D_RS14670	COG1841	ribosomal large subunit assembly
RPIC12D_RS14675	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RPIC12D_RS14680	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RPIC12D_RS14685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RPIC12D_RS14690	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RPIC12D_RS14695	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RPIC12D_RS14700	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPIC12D_RS14705	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RPIC12D_RS14710	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RPIC12D_RS14715	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RPIC12D_RS14720	COG0255	Belongs to the universal ribosomal protein uL29 family
RPIC12D_RS14725	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RPIC12D_RS14730	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RPIC12D_RS14735	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RPIC12D_RS14740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RPIC12D_RS14745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPIC12D_RS14750	COG0089	rRNA binding
RPIC12D_RS14755	COG0088	Forms part of the polypeptide exit tunnel
RPIC12D_RS14760	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RPIC12D_RS14765	COG0051	transcription antitermination factor activity, RNA binding
RPIC12D_RS14770	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIC12D_RS14775	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPIC12D_RS14780	COG0049	tRNA binding
RPIC12D_RS14785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RPIC12D_RS14790	COG2814	Major facilitator Superfamily
RPIC12D_RS14795	COG0583	DNA-binding transcription factor activity
RPIC12D_RS14800	COG0514	ATP-dependent DNA helicase (RecQ)
RPIC12D_RS14810	COG4676	Protein conserved in bacteria
RPIC12D_RS14815	COG4676	Protein conserved in bacteria
RPIC12D_RS14820	COG5445	Predicted secreted protein (DUF2300)
RPIC12D_RS14825	COG2373	Large extracellular alpha-helical protein
RPIC12D_RS14830	COG3234	Protein of unknown function (DUF1175)
RPIC12D_RS14835	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RPIC12D_RS14840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RPIC12D_RS14845	COG0085	RNA polymerase activity
RPIC12D_RS14850	COG0222	ribosome binding
RPIC12D_RS14855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RPIC12D_RS14860	COG0081	regulation of translation
RPIC12D_RS14865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RPIC12D_RS14885	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIC12D_RS14905	COG2433	Pfam Transposase IS66
RPIC12D_RS14960	COG3842	ATPase activity
RPIC12D_RS14965	COG3842	ATPase activity
RPIC12D_RS14975	COG0395	ABC-type sugar transport system, permease component
RPIC12D_RS14990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RPIC12D_RS15005	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RPIC12D_RS15055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS15060	COG0668	transmembrane transport
RPIC12D_RS15065	COG2814	Major facilitator Superfamily
RPIC12D_RS15105	COG2197	response regulator
RPIC12D_RS15135	COG0789	Transcriptional regulator
RPIC12D_RS15155	COG3245	cytochrome
RPIC12D_RS15175	COG0745	RESPONSE REGULATOR receiver
RPIC12D_RS15185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS15195	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RPIC12D_RS15200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RPIC12D_RS15205	COG2080	2 iron, 2 sulfur cluster binding
RPIC12D_RS15255	COG1522	sequence-specific DNA binding
RPIC12D_RS15285	COG2165	general secretion pathway protein
RPIC12D_RS15330	COG2826	transposase and inactivated derivatives, IS30 family
RPIC12D_RS15350	COG2925	Exonuclease
RPIC12D_RS15355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPIC12D_RS15365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC12D_RS15375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC12D_RS15380	COG2197	response regulator
RPIC12D_RS15385	COG0840	transmembrane signaling receptor activity
RPIC12D_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC12D_RS15415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC12D_RS15430	COG0477	Major facilitator Superfamily
RPIC12D_RS15435	COG0671	phosphoesterase, PA-phosphatase related
RPIC12D_RS15460	COG0459	protein refolding
RPIC12D_RS15520	COG0657	acetylesterase activity
RPIC12D_RS15540	COG1846	Transcriptional regulator
RPIC12D_RS15545	COG1764	response to oxidative stress
RPIC12D_RS15555	COG0443	Heat shock 70 kDa protein
RPIC12D_RS15565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIC12D_RS15640	COG0582	viral genome integration into host DNA
RPIC12D_RS15650	COG0737	Belongs to the 5'-nucleotidase family
RPIC12D_RS15660	COG2010	Cytochrome c
RPIC12D_RS15685	COG4654	Cytochrome c, class I
RPIC12D_RS15695	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIC12D_RS15705	COG2823	Periplasmic or secreted lipoprotein
RPIC12D_RS15710	COG0792	nuclease activity
RPIC12D_RS15725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC12D_RS15740	COG1393	Belongs to the ArsC family
RPIC12D_RS15745	COG3328	transposase activity
RPIC12D_RS15750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC12D_RS15760	COG4266	Belongs to the allantoicase family
RPIC12D_RS15765	COG1301	dicarboxylic acid transport
RPIC12D_RS15775	COG1739	Uncharacterized protein family UPF0029
RPIC12D_RS15785	COG0583	DNA-binding transcription factor activity
RPIC12D_RS15790	COG3960	tartronate-semialdehyde synthase activity
RPIC12D_RS15795	COG3622	Belongs to the hyi family
RPIC12D_RS15800	COG2084	Dehydrogenase
RPIC12D_RS15810	COG0469	pyruvate kinase activity
RPIC12D_RS15815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPIC12D_RS15825	COG0210	DNA helicase
RPIC12D_RS15840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RPIC12D_RS15845	COG0509	glycine decarboxylation via glycine cleavage system
RPIC12D_RS15850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIC12D_RS15850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIC12D_RS15860	COG1760	l-serine dehydratase
RPIC12D_RS15865	COG2826	transposase and inactivated derivatives, IS30 family
RPIC12D_RS15870	COG1297	OPT oligopeptide transporter protein
RPIC12D_RS15880	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RPIC12D_RS15890	COG0683	leucine binding
RPIC12D_RS15895	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIC12D_RS15895	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIC12D_RS15895	COG0506	proline dehydrogenase activity
RPIC12D_RS15900	COG3328	transposase activity
RPIC12D_RS15905	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RPIC12D_RS15910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RPIC12D_RS15920	COG0840	transmembrane signaling receptor activity
RPIC12D_RS15935	COG0625	glutathione transferase activity
RPIC12D_RS15955	COG1832	CoA-binding protein
RPIC12D_RS15970	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RPIC12D_RS15975	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RPIC12D_RS15980	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RPIC12D_RS15985	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RPIC12D_RS15990	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RPIC12D_RS15995	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPIC12D_RS16005	COG0356	it plays a direct role in the translocation of protons across the membrane
RPIC12D_RS16015	COG1475	DNA binding
RPIC12D_RS16020	COG1192	Involved in chromosome partitioning
RPIC12D_RS16025	COG0357	Ribosomal RNA small subunit methyltransferase G
RPIC12D_RS16030	COG0445	tRNA wobble uridine modification
RPIC12D_RS16050	COG3530	Putative quorum-sensing-regulated virulence factor
RPIC12D_RS16055	COG0583	DNA-binding transcription factor activity
RPIC12D_RS16110	COG0411	ABC transporter
RPIC12D_RS16115	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RPIC12D_RS16120	COG2267	carboxylic ester hydrolase activity
RPIC12D_RS16125	COG0789	Transcriptional regulator
RPIC12D_RS16130	COG2217	Heavy metal translocating P-type atpase
RPIC12D_RS16150	COG3047	cAMP biosynthetic process
RPIC12D_RS16155	COG2423	ornithine cyclodeaminase activity
RPIC12D_RS16170	COG3186	Phenylalanine-4-hydroxylase
RPIC12D_RS16175	COG2154	pterin-4-alpha-carbinolamine dehydratase
RPIC12D_RS16190	COG0642	Histidine kinase
RPIC12D_RS16215	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPIC12D_RS16225	COG0737	Belongs to the 5'-nucleotidase family
RPIC12D_RS16230	COG0850	regulation of cytokinetic process
RPIC12D_RS16235	COG2894	cell division
RPIC12D_RS16240	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RPIC12D_RS16250	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC12D_RS16255	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RPIC12D_RS16265	COG0306	phosphate transporter
RPIC12D_RS16270	COG1254	Belongs to the acylphosphatase family
RPIC12D_RS16280	COG1116	anion transmembrane transporter activity
RPIC12D_RS16320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RPIC12D_RS16325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RPIC12D_RS16380	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RPIC12D_RS16385	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RPIC12D_RS16390	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RPIC12D_RS16395	COG2205	protein histidine kinase activity
RPIC12D_RS16405	COG2200	EAL domain
RPIC12D_RS16405	COG2199	diguanylate cyclase activity
RPIC12D_RS16410	COG2197	response regulator
RPIC12D_RS16420	COG0477	Major facilitator Superfamily
RPIC12D_RS16430	COG1335	isochorismatase
RPIC12D_RS16445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC12D_RS16470	COG1959	2 iron, 2 sulfur cluster binding
RPIC12D_RS16490	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC12D_RS16500	COG2814	Major facilitator Superfamily
RPIC12D_RS16515	COG3257	ureidoglycine aminohydrolase activity
RPIC12D_RS16525	COG0583	DNA-binding transcription factor activity
RPIC12D_RS16545	COG0642	Histidine kinase
RPIC12D_RS16600	COG0583	DNA-binding transcription factor activity
RPIC12D_RS16620	COG1960	acyl-CoA dehydrogenase activity
RPIC12D_RS16625	COG2070	2-Nitropropane dioxygenase
RPIC12D_RS16630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RPIC12D_RS16645	COG2022	thiamine diphosphate biosynthetic process
RPIC12D_RS16655	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RPIC12D_RS16680	COG0351	phosphomethylpyrimidine kinase
RPIC12D_RS16700	COG1785	Belongs to the alkaline phosphatase family
RPIC12D_RS16710	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RPIC12D_RS16715	COG1950	PFAM Membrane protein of
RPIC12D_RS16720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RPIC12D_RS16735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RPIC12D_RS16755	COG0617	tRNA 3'-terminal CCA addition
RPIC12D_RS16760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC12D_RS16765	COG3246	L-lysine catabolic process to acetate
RPIC12D_RS16770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RPIC12D_RS16790	COG2204	response regulator
RPIC12D_RS16795	COG5000	phosphorelay sensor kinase activity
RPIC12D_RS16810	COG0501	Belongs to the peptidase M48B family
RPIC12D_RS16820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIC12D_RS16830	COG0242	peptide deformylase activity
RPIC12D_RS16835	COG1652	LysM domain
RPIC12D_RS16840	COG0758	DNA mediated transformation
RPIC12D_RS16855	COG0583	DNA-binding transcription factor activity
RPIC12D_RS16860	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC12D_RS16865	COG0772	Belongs to the SEDS family
RPIC12D_RS16870	COG0768	penicillin binding
RPIC12D_RS16880	COG1792	Involved in formation and maintenance of cell shape
RPIC12D_RS16885	COG1077	Cell shape determining protein MreB Mrl
RPIC12D_RS16890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIC12D_RS16895	COG0154	amidase activity
RPIC12D_RS16910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIC12D_RS16920	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RPIC12D_RS16940	COG2706	6-phosphogluconolactonase activity
RPIC12D_RS16950	COG0523	cobalamin synthesis protein
RPIC12D_RS16970	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RPIC12D_RS16975	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RPIC12D_RS16990	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RPIC12D_RS17020	COG1595	DNA-templated transcription, initiation
RPIC12D_RS17025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIC12D_RS17045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RPIC12D_RS17055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIC12D_RS17070	COG2879	small protein
RPIC12D_RS17075	COG1966	Carbon starvation protein
RPIC12D_RS17090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC12D_RS17095	COG2186	Transcriptional regulator
RPIC12D_RS17100	COG2084	Dehydrogenase
RPIC12D_RS17105	COG3395	kinase activity
RPIC12D_RS17110	COG0235	Class ii aldolase
RPIC12D_RS17115	COG2271	Major facilitator Superfamily
RPIC12D_RS17120	COG3622	Belongs to the hyi family
RPIC12D_RS17135	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RPIC12D_RS17140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIC12D_RS17145	COG3384	dioxygenase
RPIC12D_RS17150	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC12D_RS17160	COG1309	transcriptional regulator
RPIC12D_RS17165	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC12D_RS17170	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIC12D_RS17185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RPIC12D_RS17200	COG0494	nUDIX hydrolase
RPIC12D_RS17320	COG0582	viral genome integration into host DNA
RPIC12D_RS17325	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RPIC12D_RS17335	COG0706	membrane insertase activity
RPIC12D_RS17340	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RPIC12D_RS17345	COG0594	ribonuclease P activity
RPIC12D_RS17350	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RPIC12D_RS17365	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIC12D_RS17525	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIC12D_RS17825	COG1703	isobutyryl-CoA mutase activity
RPIC12D_RS17825	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS17825	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS17950	COG4770	biotin carboxylase activity
RPIC12D_RS18040	COG0018	arginyl-trna synthetase
RPIC12D_RS18175	COG3511	phospholipase C
RPIC12D_RS18395	COG0004	ammonium transporteR
RPIC12D_RS18425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC12D_RS18430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC12D_RS18480	COG2226	methyltransferase
RPIC12D_RS18585	COG1116	anion transmembrane transporter activity
RPIC12D_RS18745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RPIC12D_RS18800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPIC12D_RS19015	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIC12D_RS19055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIC12D_RS19080	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS19080	COG1024	Enoyl-CoA hydratase
RPIC12D_RS19115	COG5265	(ABC) transporter
RPIC12D_RS19295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RPIC12D_RS19325	COG0752	glycyl-tRNA synthetase alpha subunit
RPIC12D_RS19595	COG0429	hydrolase of the alpha beta-hydrolase fold
RPIC12D_RS20105	COG1187	pseudouridine synthase activity
RPIC12D_RS20120	COG0540	Belongs to the ATCase OTCase family
RPIC12D_RS20170	COG1086	Polysaccharide biosynthesis protein
RPIC12D_RS20380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RPIC12D_RS20870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC12D_RS21225	COG0477	Major facilitator Superfamily
RPIC12D_RS21230	COG0235	Class ii aldolase
RPIC12D_RS21275	COG2205	protein histidine kinase activity
RPIC12D_RS21275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC12D_RS21520	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIC12D_RS21545	COG0513	Belongs to the DEAD box helicase family
RPIC12D_RS21565	COG0488	(ABC) transporter
RPIC12D_RS21840	COG0443	Heat shock 70 kDa protein
RPIC12D_RS22680	COG1074	ATP-dependent DNA helicase activity
RPIC12D_RS22860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIC12D_RS23000	COG2217	Heavy metal translocating P-type atpase
RPIC12D_RS23270	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIC12D_RS23685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS23685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS23685	COG1703	isobutyryl-CoA mutase activity
RPIC12D_RS24200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC12D_RS24320	COG3511	phospholipase C
RPIC12D_RS24375	COG1301	dicarboxylic acid transport
RPIC12D_RS24605	COG0189	ligase activity
RPIC12D_RS24760	COG3328	transposase activity
RPIC12D_RS24820	COG0612	Peptidase, M16
RPIC12D_RS24845	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPIC12D_RS24940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RPIC12D_RS25260	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPIC12D_RS25315	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC12D_RS25315	COG1024	Enoyl-CoA hydratase
RPIC12D_RS25555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIC12D_RS25560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIC12D_RS25610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIC12D_RS25770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC12D_RS25850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS25850	COG1703	isobutyryl-CoA mutase activity
RPIC12D_RS25850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC12D_RS25915	COG4774	siderophore transport
RPIC12D_RS26135	COG0018	arginyl-trna synthetase
RPIC12D_RS26140	COG0018	arginyl-trna synthetase
RPIC12D_RS26380	COG1280	lysine exporter protein (LysE YggA)
RPIC12D_RS26535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RPIC12D_RS26880	COG4191	Histidine kinase
RPIC12D_RS26880	COG0784	Response regulator, receiver
RPIC12D_RS27065	COG2814	Major facilitator Superfamily