locus-tag	class	description
RPIC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIC_RS00010	COG0592	DNA-directed DNA polymerase activity
RPIC_RS00020	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RPIC_RS00055	COG2831	hemolysin activation secretion protein
RPIC_RS00075	COG0765	amino acid transport
RPIC_RS00080	COG0765	amino acid transport
RPIC_RS00090	COG3781	membrane
RPIC_RS00105	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS00120	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS00125	COG1595	DNA-templated transcription, initiation
RPIC_RS00130	COG4191	Histidine kinase
RPIC_RS00130	COG0784	Response regulator, receiver
RPIC_RS00140	COG0517	IMP dehydrogenase activity
RPIC_RS00140	COG0516	GMP reductase activity
RPIC_RS00155	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
RPIC_RS00165	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RPIC_RS00175	COG1560	Kdo2-lipid A biosynthetic process
RPIC_RS00180	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RPIC_RS00185	COG2326	polyphosphate kinase activity
RPIC_RS00190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPIC_RS00195	COG0708	Exodeoxyribonuclease III
RPIC_RS00200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RPIC_RS00210	COG1434	Gram-negative-bacterium-type cell wall biogenesis
RPIC_RS00220	COG2223	nitrite transmembrane transporter activity
RPIC_RS00230	COG4221	oxidoreductase activity
RPIC_RS00245	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIC_RS00250	COG0583	DNA-binding transcription factor activity
RPIC_RS00260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS00265	COG1131	(ABC) transporter
RPIC_RS00270	COG0842	Transport permease protein
RPIC_RS00280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPIC_RS00285	COG0037	tRNA processing
RPIC_RS00290	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPIC_RS00295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RPIC_RS00315	COG0604	alcohol dehydrogenase
RPIC_RS00320	COG0583	DNA-binding transcription factor activity
RPIC_RS00325	COG0028	Belongs to the TPP enzyme family
RPIC_RS00350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC_RS00360	COG0346	lactoylglutathione lyase activity
RPIC_RS00370	COG2814	Major facilitator Superfamily
RPIC_RS00375	COG0625	glutathione transferase activity
RPIC_RS00420	COG0004	ammonium transporteR
RPIC_RS00430	COG1703	isobutyryl-CoA mutase activity
RPIC_RS00430	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC_RS00430	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPIC_RS00435	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC_RS00460	COG0693	protein deglycase activity
RPIC_RS00465	COG0596	Alpha beta hydrolase
RPIC_RS00480	COG4774	siderophore transport
RPIC_RS00485	COG1024	Enoyl-CoA hydratase
RPIC_RS00495	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS00500	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS00510	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS00520	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS00550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIC_RS00555	COG4770	biotin carboxylase activity
RPIC_RS00560	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RPIC_RS00565	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RPIC_RS00575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPIC_RS00580	COG3012	SEC-C Motif Domain Protein
RPIC_RS00585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPIC_RS00595	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS00605	COG0183	Belongs to the thiolase family
RPIC_RS00610	COG0288	reversible hydration of carbon dioxide
RPIC_RS00615	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
RPIC_RS00620	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS00625	COG0789	Transcriptional regulator
RPIC_RS00635	COG2329	Antibiotic biosynthesis monooxygenase
RPIC_RS00645	COG4221	oxidoreductase activity
RPIC_RS00650	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RPIC_RS00660	COG0018	arginyl-trna synthetase
RPIC_RS00700	COG2197	response regulator
RPIC_RS00735	COG2267	carboxylic ester hydrolase activity
RPIC_RS00760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC_RS00795	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RPIC_RS00805	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RPIC_RS00810	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RPIC_RS00810	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RPIC_RS00815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RPIC_RS00840	COG2814	Major facilitator Superfamily
RPIC_RS00845	COG4264	IucA IucC family
RPIC_RS00850	COG3511	phospholipase C
RPIC_RS00860	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RPIC_RS00865	COG0321	lipoyl(octanoyl) transferase activity
RPIC_RS00875	COG0583	DNA-binding transcription factor activity
RPIC_RS00880	COG2921	Belongs to the UPF0250 family
RPIC_RS00885	COG1686	Belongs to the peptidase S11 family
RPIC_RS00890	COG2945	thiolester hydrolase activity
RPIC_RS00895	COG3411	Ferredoxin
RPIC_RS00900	COG1301	dicarboxylic acid transport
RPIC_RS00910	COG2204	response regulator
RPIC_RS00925	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RPIC_RS00935	COG1280	lysine exporter protein (LysE YggA)
RPIC_RS00940	COG0606	chelatase, subunit chli
RPIC_RS00965	COG0004	ammonium transporteR
RPIC_RS00975	COG0189	ligase activity
RPIC_RS00985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIC_RS00990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC_RS01010	COG0793	Belongs to the peptidase S41A family
RPIC_RS01015	COG0588	phosphoglycerate mutase activity
RPIC_RS01020	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPIC_RS01025	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RPIC_RS01030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RPIC_RS01035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RPIC_RS01045	COG1040	competence protein
RPIC_RS01050	COG2226	methyltransferase
RPIC_RS01065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIC_RS01070	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RPIC_RS01100	COG1612	heme a metabolic process
RPIC_RS01105	COG0109	protoheme IX farnesyltransferase activity
RPIC_RS01110	COG1999	signal sequence binding
RPIC_RS01115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPIC_RS01130	COG1741	Belongs to the pirin family
RPIC_RS01135	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIC_RS01140	COG1116	anion transmembrane transporter activity
RPIC_RS01145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC_RS01150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC_RS01155	COG3707	response regulator
RPIC_RS01165	COG0625	glutathione transferase activity
RPIC_RS01175	COG0612	Peptidase, M16
RPIC_RS01180	COG0612	Peptidase, M16
RPIC_RS01185	COG0742	ribosomal rna small subunit methyltransferase
RPIC_RS01190	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPIC_RS01195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPIC_RS01205	COG0193	aminoacyl-tRNA hydrolase activity
RPIC_RS01210	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RPIC_RS01215	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIC_RS01225	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RPIC_RS01230	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
RPIC_RS01240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPIC_RS01250	COG1194	a g-specific adenine glycosylase
RPIC_RS01260	COG1660	Displays ATPase and GTPase activities
RPIC_RS01270	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RPIC_RS01280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RPIC_RS01285	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RPIC_RS01290	COG1137	ATPase activity
RPIC_RS01305	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RPIC_RS01325	COG0693	protein deglycase activity
RPIC_RS01330	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RPIC_RS01335	COG1280	lysine exporter protein (LysE YggA)
RPIC_RS01350	COG2814	Major facilitator Superfamily
RPIC_RS01355	COG0629	single-stranded DNA binding
RPIC_RS01375	COG5001	Diguanylate cyclase
RPIC_RS01390	COG5001	Diguanylate cyclase
RPIC_RS01395	COG3284	Transcriptional regulator
RPIC_RS01410	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RPIC_RS01415	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RPIC_RS01425	COG0535	radical SAM domain protein
RPIC_RS01430	COG5002	protein histidine kinase activity
RPIC_RS01435	COG0745	RESPONSE REGULATOR receiver
RPIC_RS01440	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RPIC_RS01445	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIC_RS01485	COG2409	Drug exporters of the RND superfamily
RPIC_RS01500	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPIC_RS01550	COG3265	gluconokinase activity
RPIC_RS01555	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS01585	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RPIC_RS01585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RPIC_RS01590	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RPIC_RS01600	COG0700	Nucleoside recognition
RPIC_RS01605	COG1238	metal cluster binding
RPIC_RS01620	COG4178	(ABC) transporter
RPIC_RS01630	COG2226	methyltransferase
RPIC_RS01645	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIC_RS01670	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPIC_RS01680	COG0494	nUDIX hydrolase
RPIC_RS01685	COG3568	Endonuclease Exonuclease Phosphatase
RPIC_RS01690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIC_RS01705	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS01710	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC_RS01710	COG1024	Enoyl-CoA hydratase
RPIC_RS01715	COG0183	Belongs to the thiolase family
RPIC_RS01725	COG1024	Enoyl-CoA hydratase
RPIC_RS01730	COG1607	acyl-coa hydrolase
RPIC_RS01735	COG5265	(ABC) transporter
RPIC_RS01745	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RPIC_RS01755	COG0765	amino acid transport
RPIC_RS01760	COG0765	amino acid transport
RPIC_RS01765	COG1126	abc transporter atp-binding protein
RPIC_RS01770	COG0121	glutamine amidotransferase
RPIC_RS01780	COG0418	dihydroorotase activity
RPIC_RS01795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RPIC_RS01800	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RPIC_RS01815	COG0316	Belongs to the HesB IscA family
RPIC_RS01820	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RPIC_RS01825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RPIC_RS01830	COG1490	D-aminoacyl-tRNA deacylase activity
RPIC_RS01845	COG2255	four-way junction helicase activity
RPIC_RS01850	COG0632	four-way junction helicase activity
RPIC_RS01860	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RPIC_RS01865	COG0138	bifunctional purine biosynthesis protein purh
RPIC_RS01870	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
RPIC_RS01875	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RPIC_RS01880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC_RS01885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPIC_RS01890	COG0006	proline dipeptidase activity
RPIC_RS01900	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPIC_RS01920	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RPIC_RS01925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC_RS01930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RPIC_RS01935	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPIC_RS01945	COG0346	lactoylglutathione lyase activity
RPIC_RS01955	COG0204	Acyl-transferase
RPIC_RS01960	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RPIC_RS01965	COG0751	glycine-tRNA ligase activity
RPIC_RS01975	COG0752	glycyl-tRNA synthetase alpha subunit
RPIC_RS01980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RPIC_RS01985	COG4535	Mg2 and Co2 transporter CorC
RPIC_RS01995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RPIC_RS02000	COG1702	phosphate starvation-inducible protein PhoH
RPIC_RS02005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIC_RS02030	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS02060	COG0513	Belongs to the DEAD box helicase family
RPIC_RS02100	COG0583	DNA-binding transcription factor activity
RPIC_RS02110	COG2988	succinylglutamate desuccinylase activity
RPIC_RS02125	COG0596	Alpha beta hydrolase
RPIC_RS02125	COG2945	thiolester hydrolase activity
RPIC_RS02185	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RPIC_RS02270	COG0477	Major facilitator Superfamily
RPIC_RS02275	COG3162	membrane
RPIC_RS02280	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIC_RS02290	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RPIC_RS02300	COG0642	Histidine kinase
RPIC_RS02310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RPIC_RS02315	COG2137	regulation of response to DNA damage stimulus
RPIC_RS02325	COG0045	succinate-CoA ligase (ADP-forming) activity
RPIC_RS02335	COG0861	Integral membrane protein TerC family
RPIC_RS02340	COG4969	Belongs to the N-Me-Phe pilin family
RPIC_RS02345	COG4969	Belongs to the N-Me-Phe pilin family
RPIC_RS02350	COG3307	-O-antigen
RPIC_RS02355	COG4969	Belongs to the N-Me-Phe pilin family
RPIC_RS02360	COG0315	cyclic pyranopterin monophosphate synthase activity
RPIC_RS02365	COG4783	chaperone-mediated protein folding
RPIC_RS02375	COG0429	hydrolase of the alpha beta-hydrolase fold
RPIC_RS02385	COG0859	PFAM glycosyl transferase family 9
RPIC_RS02410	COG0126	phosphoglycerate kinase activity
RPIC_RS02425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPIC_RS02430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RPIC_RS02435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RPIC_RS02440	COG0009	L-threonylcarbamoyladenylate synthase
RPIC_RS02450	COG1763	Mo-molybdopterin cofactor biosynthetic process
RPIC_RS02455	COG2027	D-alanyl-D-alanine carboxypeptidase
RPIC_RS02465	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPIC_RS02485	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RPIC_RS02490	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RPIC_RS02500	COG0840	transmembrane signaling receptor activity
RPIC_RS02510	COG0154	amidase activity
RPIC_RS02590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC_RS02600	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPIC_RS02600	COG3008	intermembrane lipid transfer
RPIC_RS02605	COG2995	paraquat-inducible protein a
RPIC_RS02610	COG2995	paraquat-inducible protein a
RPIC_RS02630	COG0840	transmembrane signaling receptor activity
RPIC_RS02640	COG3706	GGDEF domain
RPIC_RS02645	COG2329	Antibiotic biosynthesis monooxygenase
RPIC_RS02650	COG0628	permease
RPIC_RS02655	COG3268	Saccharopine dehydrogenase
RPIC_RS02675	COG0583	DNA-binding transcription factor activity
RPIC_RS02680	COG3706	GGDEF domain
RPIC_RS02680	COG4251	negative regulation of phosphorylation
RPIC_RS02680	COG2203	Gaf domain
RPIC_RS02680	COG5001	Diguanylate cyclase
RPIC_RS02685	COG0702	epimerase
RPIC_RS02690	COG0583	DNA-binding transcription factor activity
RPIC_RS02750	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RPIC_RS02755	COG1454	alcohol dehydrogenase
RPIC_RS02760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC_RS02770	COG1230	cation diffusion facilitator family transporter
RPIC_RS02780	COG1858	cytochrome C peroxidase
RPIC_RS02810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPIC_RS02815	COG0459	protein refolding
RPIC_RS02820	COG4269	membrane
RPIC_RS02875	COG4964	Belongs to the GSP D family
RPIC_RS02920	COG0463	Glycosyl transferase, family 2
RPIC_RS02955	COG1704	LemA family
RPIC_RS02965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC_RS02970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RPIC_RS02975	COG1773	rubredoxin
RPIC_RS02995	COG0840	transmembrane signaling receptor activity
RPIC_RS03000	COG2198	Histidine kinase
RPIC_RS03000	COG0643	Histidine kinase
RPIC_RS03005	COG0415	Belongs to the DNA photolyase family
RPIC_RS03010	COG1187	pseudouridine synthase activity
RPIC_RS03015	COG1678	Uncharacterized ACR, COG1678
RPIC_RS03020	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RPIC_RS03025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
RPIC_RS03030	COG0540	Belongs to the ATCase OTCase family
RPIC_RS03045	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RPIC_RS03055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIC_RS03080	COG1216	Glycosyl transferase, family 2
RPIC_RS03090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIC_RS03115	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RPIC_RS03130	COG0859	PFAM glycosyl transferase family 9
RPIC_RS03145	COG1538	Outer membrane efflux protein
RPIC_RS03155	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIC_RS03175	COG1968	undecaprenyl-diphosphatase activity
RPIC_RS03180	COG1902	pentaerythritol trinitrate reductase activity
RPIC_RS03185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RPIC_RS03200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIC_RS03210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RPIC_RS03220	COG0436	Aminotransferase
RPIC_RS03225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIC_RS03230	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RPIC_RS03245	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPIC_RS03245	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPIC_RS03305	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RPIC_RS03310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RPIC_RS03315	COG4221	oxidoreductase activity
RPIC_RS03320	COG0824	Thioesterase
RPIC_RS03340	COG0823	Involved in the tonB-independent uptake of proteins
RPIC_RS03345	COG2885	chlorophyll binding
RPIC_RS03355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RPIC_RS03360	COG2391	methyltransferase activity
RPIC_RS03375	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC_RS03385	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPIC_RS03390	COG1609	Transcriptional regulator
RPIC_RS03405	COG2175	clavaminate synthase activity
RPIC_RS03415	COG0390	transport system, permease component
RPIC_RS03420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIC_RS03440	COG4575	ribosome binding
RPIC_RS03445	COG0450	alkyl hydroperoxide reductase
RPIC_RS03450	COG2252	PERMEase
RPIC_RS03455	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS03465	COG3483	tryptophan 2,3-dioxygenase activity
RPIC_RS03475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
RPIC_RS03480	COG1522	sequence-specific DNA binding
RPIC_RS03495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIC_RS03505	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RPIC_RS03510	COG0259	pyridoxamine-phosphate oxidase activity
RPIC_RS03530	COG2982	Protein involved in outer membrane biogenesis
RPIC_RS03535	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
RPIC_RS03545	COG2703	oxygen carrier activity
RPIC_RS03555	COG3118	belongs to the thioredoxin family
RPIC_RS03560	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS03570	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RPIC_RS03585	COG4681	YaeQ
RPIC_RS03610	COG2353	YceI-like domain
RPIC_RS03615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC_RS03625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
RPIC_RS03645	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS03650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIC_RS03670	COG0330	HflC and HflK could
RPIC_RS03685	COG0477	Major facilitator Superfamily
RPIC_RS03690	COG0235	Class ii aldolase
RPIC_RS03695	COG1942	4-Oxalocrotonate Tautomerase
RPIC_RS03710	COG0425	Belongs to the sulfur carrier protein TusA family
RPIC_RS03715	COG1280	lysine exporter protein (LysE YggA)
RPIC_RS03725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC_RS03725	COG2205	protein histidine kinase activity
RPIC_RS03735	COG3121	Chaperone
RPIC_RS03740	COG3188	usher protein
RPIC_RS03760	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RPIC_RS03785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RPIC_RS03790	COG1605	Chorismate mutase
RPIC_RS03790	COG0077	Prephenate dehydratase
RPIC_RS03795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIC_RS03800	COG0287	Prephenate dehydrogenase
RPIC_RS03805	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RPIC_RS03810	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RPIC_RS03820	COG0776	regulation of translation
RPIC_RS03830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
RPIC_RS03840	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RPIC_RS03845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC_RS03860	COG2951	lytic endotransglycosylase activity
RPIC_RS03865	COG0123	including yeast histone deacetylase and acetoin utilization protein
RPIC_RS03870	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPIC_RS03875	COG2011	ABC-type metal ion transport system permease component
RPIC_RS03880	COG1464	Belongs to the NlpA lipoprotein family
RPIC_RS03895	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS03900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC_RS03940	COG0228	four-way junction DNA binding
RPIC_RS03945	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RPIC_RS03950	COG0336	Belongs to the RNA methyltransferase TrmD family
RPIC_RS03955	COG0335	large ribosomal subunit rRNA binding
RPIC_RS03965	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RPIC_RS03975	COG1162	GTPase activity
RPIC_RS03980	COG0501	Belongs to the peptidase M48B family
RPIC_RS03985	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
RPIC_RS03990	COG0521	Mo-molybdopterin cofactor biosynthetic process
RPIC_RS03995	COG3028	Belongs to the UPF0307 family
RPIC_RS04000	COG0312	modulator of DNA gyrase
RPIC_RS04010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIC_RS04020	COG0861	Integral membrane protein TerC family
RPIC_RS04025	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RPIC_RS04030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPIC_RS04035	COG0513	Belongs to the DEAD box helicase family
RPIC_RS04065	COG0488	(ABC) transporter
RPIC_RS04105	COG1132	(ABC) transporter
RPIC_RS04110	COG1620	l-lactate permease
RPIC_RS04115	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPIC_RS04135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIC_RS04150	COG0625	glutathione transferase activity
RPIC_RS04155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC_RS04165	COG0697	spore germination
RPIC_RS04170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPIC_RS04180	COG0326	Molecular chaperone. Has ATPase activity
RPIC_RS04210	COG0840	transmembrane signaling receptor activity
RPIC_RS04240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPIC_RS04245	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC_RS04275	COG0778	Nitroreductase
RPIC_RS04280	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RPIC_RS04285	COG2878	Part of a membrane complex involved in electron transport
RPIC_RS04290	COG1309	transcriptional regulator
RPIC_RS04305	COG0556	nucleotide-excision repair
RPIC_RS04315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC_RS04320	COG1609	Transcriptional regulator
RPIC_RS04325	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIC_RS04335	COG1879	ABC-type sugar transport system periplasmic component
RPIC_RS04345	COG1104	cysteine desulfurase activity
RPIC_RS04350	COG0822	iron-sulfur transferase activity
RPIC_RS04355	COG0316	Belongs to the HesB IscA family
RPIC_RS04365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RPIC_RS04370	COG0443	Heat shock 70 kDa protein
RPIC_RS04390	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RPIC_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS04400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RPIC_RS04405	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RPIC_RS04440	COG0746	molybdenum cofactor guanylyltransferase activity
RPIC_RS04445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RPIC_RS04450	COG1530	ribonuclease E activity
RPIC_RS04460	COG0546	phosphoglycolate phosphatase activity
RPIC_RS04470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPIC_RS04470	COG0616	signal peptide processing
RPIC_RS04480	COG0424	maF-like protein
RPIC_RS04490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RPIC_RS04495	COG0416	fatty acid biosynthetic process
RPIC_RS04500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPIC_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS04515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPIC_RS04520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPIC_RS04525	COG1595	DNA-templated transcription, initiation
RPIC_RS04540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC_RS04550	COG0481	GTPase activity
RPIC_RS04555	COG0681	Belongs to the peptidase S26 family
RPIC_RS04565	COG0571	ribonuclease III activity
RPIC_RS04570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RPIC_RS04575	COG1381	Involved in DNA repair and RecF pathway recombination
RPIC_RS04580	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RPIC_RS04585	COG0736	holo-[acyl-carrier-protein] synthase activity
RPIC_RS04595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RPIC_RS04605	COG0322	excinuclease ABC activity
RPIC_RS04635	COG0745	RESPONSE REGULATOR receiver
RPIC_RS04645	COG4251	negative regulation of phosphorylation
RPIC_RS04655	COG0745	RESPONSE REGULATOR receiver
RPIC_RS04675	COG2271	Major facilitator Superfamily
RPIC_RS04685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS04700	COG0583	DNA-binding transcription factor activity
RPIC_RS04705	COG2855	membrane
RPIC_RS04730	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RPIC_RS04745	COG1136	(ABC) transporter
RPIC_RS04750	COG0084	hydrolase, TatD family'
RPIC_RS04760	COG2308	Evidence 4 Homologs of previously reported genes of
RPIC_RS04780	COG2267	carboxylic ester hydrolase activity
RPIC_RS04785	COG0504	CTP synthase activity
RPIC_RS04790	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RPIC_RS04800	COG0148	phosphopyruvate hydratase activity
RPIC_RS04805	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
RPIC_RS04815	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RPIC_RS04825	COG2833	Protein of unknown function (DUF455)
RPIC_RS04830	COG2267	carboxylic ester hydrolase activity
RPIC_RS04835	COG3011	Protein conserved in bacteria
RPIC_RS04845	COG0492	ferredoxin-NADP+ reductase activity
RPIC_RS04850	COG0613	PHP domain protein
RPIC_RS04855	COG0009	L-threonylcarbamoyladenylate synthase
RPIC_RS04860	COG1994	Peptidase M50
RPIC_RS04865	COG0180	Tryptophanyl-tRNA synthetase
RPIC_RS04875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPIC_RS04880	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
RPIC_RS04895	COG2850	peptidyl-arginine hydroxylation
RPIC_RS04910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RPIC_RS04915	COG0583	DNA-binding transcription factor activity
RPIC_RS04920	COG0840	transmembrane signaling receptor activity
RPIC_RS04930	COG2258	MOSC domain
RPIC_RS04950	COG0483	inositol monophosphate 1-phosphatase activity
RPIC_RS04955	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RPIC_RS04960	COG1045	serine acetyltransferase
RPIC_RS04965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC_RS04970	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RPIC_RS04985	COG0215	cysteine-tRNA ligase activity
RPIC_RS04990	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
RPIC_RS04995	COG0825	malonyl-CoA metabolic process
RPIC_RS05000	COG0037	tRNA processing
RPIC_RS05005	COG0527	aspartate kinase activity
RPIC_RS05020	COG4166	transmembrane transport
RPIC_RS05025	COG4174	ABC transporter (Permease)
RPIC_RS05030	COG4239	(ABC) transporter, permease
RPIC_RS05035	COG4172	Belongs to the ABC transporter superfamily
RPIC_RS05040	COG0791	NLP P60 protein
RPIC_RS05055	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPIC_RS05060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC_RS05080	COG0534	Mate efflux family protein
RPIC_RS05090	COG0254	rRNA binding
RPIC_RS05100	COG3228	Belongs to the MtfA family
RPIC_RS05105	COG2197	response regulator
RPIC_RS05120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RPIC_RS05135	COG1074	ATP-dependent DNA helicase activity
RPIC_RS05140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RPIC_RS05145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RPIC_RS05150	COG2329	Antibiotic biosynthesis monooxygenase
RPIC_RS05155	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RPIC_RS05170	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS05175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC_RS05185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC_RS05190	COG1309	transcriptional regulator
RPIC_RS05195	COG1902	pentaerythritol trinitrate reductase activity
RPIC_RS05200	COG0604	alcohol dehydrogenase
RPIC_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS05200	COG3321	synthase
RPIC_RS05205	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RPIC_RS05210	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPIC_RS05215	COG1388	LysM domain
RPIC_RS05215	COG4942	peptidase
RPIC_RS05230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RPIC_RS05235	COG0670	Belongs to the BI1 family
RPIC_RS05240	COG0105	UTP biosynthetic process
RPIC_RS05245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RPIC_RS05260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RPIC_RS05265	COG0124	histidyl-tRNA synthetase
RPIC_RS05270	COG2976	Protein conserved in bacteria
RPIC_RS05280	COG1160	GTP binding
RPIC_RS05285	COG1923	regulation of RNA biosynthetic process
RPIC_RS05290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RPIC_RS05295	COG0330	HflC and HflK could
RPIC_RS05300	COG0330	HflC and HflK could
RPIC_RS05310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RPIC_RS05315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RPIC_RS05320	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RPIC_RS05330	COG0557	exoribonuclease II activity
RPIC_RS05335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIC_RS05340	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RPIC_RS05345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIC_RS05350	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RPIC_RS05355	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
RPIC_RS05360	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RPIC_RS05360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIC_RS05365	COG1643	Atp-dependent helicase
RPIC_RS05390	COG1546	Belongs to the CinA family
RPIC_RS05390	COG1058	Belongs to the CinA family
RPIC_RS05400	COG0174	glutamine synthetase
RPIC_RS05410	COG3852	Histidine kinase
RPIC_RS05415	COG2204	response regulator
RPIC_RS05430	COG1653	transport
RPIC_RS05435	COG1175	transmembrane transport
RPIC_RS05445	COG3842	ATPase activity
RPIC_RS05450	COG0584	glycerophosphoryl diester phosphodiesterase
RPIC_RS05455	COG0567	Dehydrogenase, E1 component
RPIC_RS05460	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC_RS05465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC_RS05470	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RPIC_RS05480	COG2217	Heavy metal translocating P-type atpase
RPIC_RS05490	COG3278	Belongs to the heme-copper respiratory oxidase family
RPIC_RS05510	COG0348	domain, Protein
RPIC_RS05525	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC_RS05535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RPIC_RS05545	COG0779	Required for maturation of 30S ribosomal subunits
RPIC_RS05550	COG0195	Participates in both transcription termination and antitermination
RPIC_RS05550	COG2251	uridine kinase activity
RPIC_RS05555	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RPIC_RS05560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RPIC_RS05565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RPIC_RS05580	COG2814	Major facilitator Superfamily
RPIC_RS05585	COG1566	PFAM secretion protein HlyD family protein
RPIC_RS05595	COG1846	Transcriptional regulator
RPIC_RS05600	COG1217	gtp-binding protein TYPA
RPIC_RS05610	COG0583	DNA-binding transcription factor activity
RPIC_RS05620	COG1024	Enoyl-CoA hydratase
RPIC_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS05680	COG0156	8-amino-7-oxononanoate synthase activity
RPIC_RS05685	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RPIC_RS05690	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS05690	COG3321	synthase
RPIC_RS05690	COG0604	alcohol dehydrogenase
RPIC_RS05695	COG1368	sulfuric ester hydrolase activity
RPIC_RS05745	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RPIC_RS05805	COG2433	Pfam Transposase IS66
RPIC_RS05810	COG3706	GGDEF domain
RPIC_RS05815	COG2200	EAL domain
RPIC_RS05815	COG2199	diguanylate cyclase activity
RPIC_RS05840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC_RS05855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPIC_RS05870	COG0360	Binds together with S18 to 16S ribosomal RNA
RPIC_RS05880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RPIC_RS05885	COG0359	binds to the 23S rRNA
RPIC_RS05890	COG0305	Participates in initiation and elongation during chromosome replication
RPIC_RS05900	COG0306	phosphate transporter
RPIC_RS05905	COG0791	NLP P60 protein
RPIC_RS05915	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
RPIC_RS05920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RPIC_RS05930	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIC_RS05930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC_RS05945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPIC_RS05950	COG2076	Multidrug Resistance protein
RPIC_RS05955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RPIC_RS05965	COG0436	Aminotransferase
RPIC_RS05980	COG1573	uracil-dna glycosylase
RPIC_RS05990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
RPIC_RS05995	COG0314	molybdopterin synthase activity
RPIC_RS06000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPIC_RS06010	COG0542	response to heat
RPIC_RS06015	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RPIC_RS06020	COG0431	NADPH-dependent FMN reductase
RPIC_RS06025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC_RS06030	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC_RS06035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC_RS06040	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC_RS06045	COG1116	anion transmembrane transporter activity
RPIC_RS06065	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RPIC_RS06070	COG4208	sulfate ABC transporter
RPIC_RS06075	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RPIC_RS06080	COG0583	DNA-binding transcription factor activity
RPIC_RS06090	COG2972	Histidine kinase
RPIC_RS06105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RPIC_RS06120	COG2224	Isocitrate lyase
RPIC_RS06130	COG0583	DNA-binding transcription factor activity
RPIC_RS06140	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RPIC_RS06150	COG2814	Major facilitator Superfamily
RPIC_RS06160	COG1214	PFAM Peptidase M22, glycoprotease
RPIC_RS06170	COG1573	uracil-dna glycosylase
RPIC_RS06175	COG0477	Major facilitator Superfamily
RPIC_RS06180	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RPIC_RS06190	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RPIC_RS06205	COG0488	(ABC) transporter
RPIC_RS06220	COG4172	Belongs to the ABC transporter superfamily
RPIC_RS06225	COG0747	negative chemotaxis
RPIC_RS06230	COG0601	transmembrane transport
RPIC_RS06235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIC_RS06265	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIC_RS06275	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC_RS06280	COG1393	Belongs to the ArsC family
RPIC_RS06290	COG2171	N-acyltransferase activity
RPIC_RS06305	COG0596	Alpha beta hydrolase
RPIC_RS06320	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RPIC_RS06325	COG0242	peptide deformylase activity
RPIC_RS06335	COG1187	pseudouridine synthase activity
RPIC_RS06340	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RPIC_RS06345	COG0024	Methionine aminopeptidase
RPIC_RS06350	COG0052	Belongs to the universal ribosomal protein uS2 family
RPIC_RS06355	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RPIC_RS06360	COG0528	UMP kinase activity
RPIC_RS06365	COG0233	cytoplasmic translational termination
RPIC_RS06370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPIC_RS06375	COG0575	Belongs to the CDS family
RPIC_RS06380	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RPIC_RS06385	COG0750	zinc metalloprotease
RPIC_RS06400	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC_RS06405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPIC_RS06410	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC_RS06415	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC_RS06420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RPIC_RS06425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPIC_RS06445	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RPIC_RS06460	COG0330	HflC and HflK could
RPIC_RS06465	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RPIC_RS06470	COG2867	negative regulation of translational initiation
RPIC_RS06475	COG2914	Belongs to the UPF0125 (RnfH) family
RPIC_RS06485	COG0697	spore germination
RPIC_RS06500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPIC_RS06500	COG0519	Catalyzes the synthesis of GMP from XMP
RPIC_RS06505	COG1278	Cold shock
RPIC_RS06535	COG1823	symporter activity
RPIC_RS06540	COG0583	DNA-binding transcription factor activity
RPIC_RS06545	COG3485	protocatechuate 3,4-dioxygenase
RPIC_RS06550	COG3485	protocatechuate 3,4-dioxygenase
RPIC_RS06570	COG0583	DNA-binding transcription factor activity
RPIC_RS06590	COG0583	DNA-binding transcription factor activity
RPIC_RS06595	COG0477	Major facilitator Superfamily
RPIC_RS06600	COG0602	queuosine metabolic process
RPIC_RS06605	COG0720	synthase
RPIC_RS06615	COG1619	proteins homologs of microcin C7 resistance protein MccF
RPIC_RS06620	COG0488	(ABC) transporter
RPIC_RS06630	COG0427	acetyl-CoA hydrolase
RPIC_RS06635	COG0583	DNA-binding transcription factor activity
RPIC_RS06655	COG3387	PFAM Glycoside hydrolase 15-related
RPIC_RS06665	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RPIC_RS06695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RPIC_RS06730	COG3045	CreA protein
RPIC_RS06750	COG0583	DNA-binding transcription factor activity
RPIC_RS06755	COG4948	Mandelate Racemase Muconate Lactonizing
RPIC_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS06790	COG2814	Major facilitator Superfamily
RPIC_RS06795	COG3135	benzoate transporter
RPIC_RS06805	COG0156	8-amino-7-oxononanoate synthase activity
RPIC_RS06810	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RPIC_RS06835	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIC_RS06845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS06850	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIC_RS06855	COG0066	3-isopropylmalate dehydratase activity
RPIC_RS06860	COG2814	Major facilitator Superfamily
RPIC_RS06980	COG1473	amidohydrolase
RPIC_RS06985	COG0154	amidase activity
RPIC_RS07000	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RPIC_RS07005	COG3842	ATPase activity
RPIC_RS07010	COG4208	sulfate ABC transporter
RPIC_RS07015	COG1176	ABC-type spermidine putrescine transport system, permease component I
RPIC_RS07020	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIC_RS07025	COG1609	Transcriptional regulator
RPIC_RS07030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPIC_RS07040	COG0084	hydrolase, TatD family'
RPIC_RS07050	COG0470	DNA polymerase III
RPIC_RS07055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RPIC_RS07060	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RPIC_RS07100	COG0657	acetylesterase activity
RPIC_RS07110	COG0596	Alpha beta hydrolase
RPIC_RS07130	COG2130	NADP-dependent
RPIC_RS07150	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS07155	COG0183	Belongs to the thiolase family
RPIC_RS07160	COG1335	isochorismatase
RPIC_RS07165	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC_RS07165	COG1024	Enoyl-CoA hydratase
RPIC_RS07170	COG0833	amino acid
RPIC_RS07175	COG0833	amino acid
RPIC_RS07195	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPIC_RS07205	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS07210	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RPIC_RS07215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPIC_RS07220	COG2917	probably involved in intracellular septation
RPIC_RS07230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC_RS07245	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RPIC_RS07265	COG3842	ATPase activity
RPIC_RS07275	COG1176	ABC-type spermidine putrescine transport system, permease component I
RPIC_RS07280	COG1177	transmembrane transport
RPIC_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS07295	COG0583	DNA-binding transcription factor activity
RPIC_RS07310	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIC_RS07325	COG3253	May function as heme-dependent peroxidase
RPIC_RS07345	COG2433	Pfam Transposase IS66
RPIC_RS07370	COG4106	trans-aconitate 2-methyltransferase activity
RPIC_RS07380	COG0583	DNA-binding transcription factor activity
RPIC_RS07455	COG4974	Belongs to the 'phage' integrase family
RPIC_RS07460	COG1192	Involved in chromosome partitioning
RPIC_RS07465	COG1475	DNA binding
RPIC_RS07475	COG0210	DNA helicase
RPIC_RS07545	COG4962	Type ii secretion system protein e
RPIC_RS07555	COG3504	Conjugal transfer protein
RPIC_RS07600	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RPIC_RS07665	COG0629	single-stranded DNA binding
RPIC_RS07745	COG0210	DNA helicase
RPIC_RS07760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC_RS07825	COG1230	cation diffusion facilitator family transporter
RPIC_RS07875	COG1475	DNA binding
RPIC_RS08065	COG0672	)-iron permease
RPIC_RS08070	COG0789	Transcriptional regulator
RPIC_RS08090	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIC_RS08095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS08170	COG1136	(ABC) transporter
RPIC_RS08175	COG0577	efflux transmembrane transporter activity
RPIC_RS08215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS08225	COG0745	RESPONSE REGULATOR receiver
RPIC_RS08245	COG1230	cation diffusion facilitator family transporter
RPIC_RS08305	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC_RS08320	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPIC_RS08325	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
RPIC_RS08330	COG1704	LemA family
RPIC_RS08335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
RPIC_RS08365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC_RS08370	COG4716	Myosin-crossreactive antigen
RPIC_RS08390	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RPIC_RS08395	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RPIC_RS08400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPIC_RS08405	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RPIC_RS08425	COG5002	protein histidine kinase activity
RPIC_RS08430	COG0745	RESPONSE REGULATOR receiver
RPIC_RS08435	COG2132	Multicopper oxidase
RPIC_RS08485	COG4974	Belongs to the 'phage' integrase family
RPIC_RS08495	COG4644	lycopene metabolic process
RPIC_RS08505	COG0582	viral genome integration into host DNA
RPIC_RS08520	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIC_RS08545	COG5002	protein histidine kinase activity
RPIC_RS08555	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC_RS08580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RPIC_RS08590	COG0463	Glycosyl transferase, family 2
RPIC_RS08610	COG1815	bacterial-type flagellum-dependent cell motility
RPIC_RS08615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS08675	COG1285	pathogenesis
RPIC_RS08725	COG2132	Multicopper oxidase
RPIC_RS08730	COG0745	RESPONSE REGULATOR receiver
RPIC_RS08735	COG5002	protein histidine kinase activity
RPIC_RS08790	COG4232	protein-disulfide reductase activity
RPIC_RS08800	COG0723	plastoquinol--plastocyanin reductase activity
RPIC_RS08855	COG0789	Transcriptional regulator
RPIC_RS08870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS08905	COG0789	Transcriptional regulator
RPIC_RS08910	COG0672	)-iron permease
RPIC_RS08915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIC_RS08915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RPIC_RS08920	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RPIC_RS08925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RPIC_RS08935	COG0346	lactoylglutathione lyase activity
RPIC_RS08945	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RPIC_RS09020	COG2132	Multicopper oxidase
RPIC_RS09025	COG0745	RESPONSE REGULATOR receiver
RPIC_RS09030	COG5002	protein histidine kinase activity
RPIC_RS09070	COG2132	Multicopper oxidase
RPIC_RS09080	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIC_RS09095	COG3253	May function as heme-dependent peroxidase
RPIC_RS09105	COG0047	phosphoribosylformylglycinamidine synthase activity
RPIC_RS09105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPIC_RS09115	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RPIC_RS09115	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RPIC_RS09120	COG0166	Belongs to the GPI family
RPIC_RS09125	COG4181	ATPase activity
RPIC_RS09140	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC_RS09155	COG0776	regulation of translation
RPIC_RS09160	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC_RS09165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RPIC_RS09170	COG0740	serine-type endopeptidase activity
RPIC_RS09175	COG0544	peptidyl-prolyl cis-trans isomerase activity
RPIC_RS09180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC_RS09180	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RPIC_RS09195	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RPIC_RS09200	COG1845	cytochrome c oxidase, subunit III
RPIC_RS09205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPIC_RS09210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPIC_RS09215	COG0477	Major facilitator Superfamily
RPIC_RS09230	COG3473	Maleate cis-trans isomerase
RPIC_RS09265	COG1730	sister chromatid segregation
RPIC_RS09270	COG1858	cytochrome C peroxidase
RPIC_RS09285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS09320	COG0450	alkyl hydroperoxide reductase
RPIC_RS09325	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS09330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RPIC_RS09335	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RPIC_RS09340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RPIC_RS09350	COG0560	Phosphoserine phosphatase
RPIC_RS09355	COG4804	nuclease activity
RPIC_RS09360	COG0626	cystathionine gamma-synthase activity
RPIC_RS09370	COG0183	Belongs to the thiolase family
RPIC_RS09375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPIC_RS09380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RPIC_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS09395	COG0183	Belongs to the thiolase family
RPIC_RS09400	COG3243	poly(R)-hydroxyalkanoic acid synthase
RPIC_RS09410	COG1496	oxidoreductase activity
RPIC_RS09415	COG0564	pseudouridine synthase activity
RPIC_RS09425	COG1199	ATP-dependent helicase activity
RPIC_RS09440	COG2183	response to ionizing radiation
RPIC_RS09450	COG3158	transport of potassium into the cell
RPIC_RS09460	COG0167	dihydroorotate dehydrogenase activity
RPIC_RS09480	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RPIC_RS09485	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RPIC_RS09500	COG1139	Iron-sulfur cluster binding protein
RPIC_RS09505	COG0247	lactate metabolic process
RPIC_RS09510	COG1414	Transcriptional regulator
RPIC_RS09525	COG0824	Thioesterase
RPIC_RS09535	COG0123	including yeast histone deacetylase and acetoin utilization protein
RPIC_RS09550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC_RS09560	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC_RS09565	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
RPIC_RS09575	COG4566	intracellular signal transduction
RPIC_RS09580	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RPIC_RS09585	COG0339	signal peptide processing
RPIC_RS09595	COG1846	Transcriptional regulator
RPIC_RS09605	COG3971	2-oxopent-4-enoate hydratase activity
RPIC_RS09615	COG3384	dioxygenase
RPIC_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
RPIC_RS09640	COG0531	amino acid
RPIC_RS09645	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPIC_RS09660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS09665	COG2207	Transcriptional regulator
RPIC_RS09690	COG0776	regulation of translation
RPIC_RS09695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC_RS09695	COG0072	phenylalanine-tRNA ligase activity
RPIC_RS09700	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RPIC_RS09705	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RPIC_RS09710	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RPIC_RS09715	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RPIC_RS09720	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RPIC_RS09730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIC_RS09735	COG0251	oxidation-reduction process
RPIC_RS09745	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS09760	COG4566	intracellular signal transduction
RPIC_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS09775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RPIC_RS09780	COG0545	Peptidyl-prolyl cis-trans isomerase
RPIC_RS09785	COG0477	Major facilitator Superfamily
RPIC_RS09800	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPIC_RS09800	COG0596	Alpha beta hydrolase
RPIC_RS09810	COG1295	ribonuclease BN
RPIC_RS09825	COG0277	FAD linked oxidase domain protein
RPIC_RS09845	COG1522	sequence-specific DNA binding
RPIC_RS09855	COG1522	sequence-specific DNA binding
RPIC_RS09860	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RPIC_RS09875	COG0656	L-ascorbic acid biosynthetic process
RPIC_RS09880	COG1902	pentaerythritol trinitrate reductase activity
RPIC_RS09880	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIC_RS09900	COG0583	DNA-binding transcription factor activity
RPIC_RS09910	COG0640	Transcriptional regulator
RPIC_RS09915	COG0730	response to heat
RPIC_RS09935	COG0248	Ppx GppA phosphatase
RPIC_RS09940	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RPIC_RS09950	COG0745	RESPONSE REGULATOR receiver
RPIC_RS09960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPIC_RS09965	COG0581	inorganic phosphate transmembrane transporter activity
RPIC_RS09970	COG0573	inorganic phosphate transmembrane transporter activity
RPIC_RS09975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RPIC_RS09980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPIC_RS09985	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPIC_RS09990	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC_RS09995	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RPIC_RS10000	COG1534	Rna-binding protein
RPIC_RS10010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIC_RS10015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RPIC_RS10025	COG0505	Belongs to the CarA family
RPIC_RS10035	COG1388	LysM domain
RPIC_RS10035	COG0741	lytic transglycosylase activity
RPIC_RS10040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC_RS10045	COG2226	methyltransferase
RPIC_RS10050	COG0328	RNA-DNA hybrid ribonuclease activity
RPIC_RS10060	COG3772	lysozyme
RPIC_RS10075	COG2197	response regulator
RPIC_RS10085	COG2719	SpoVR family
RPIC_RS10090	COG2718	Belongs to the UPF0229 family
RPIC_RS10095	COG2766	serine protein kinase
RPIC_RS10100	COG0583	DNA-binding transcription factor activity
RPIC_RS10140	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS10145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS10150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIC_RS10160	COG0477	Major facilitator Superfamily
RPIC_RS10185	COG0582	viral genome integration into host DNA
RPIC_RS10195	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RPIC_RS10240	COG2072	flavoprotein involved in K transport
RPIC_RS10245	COG0601	transmembrane transport
RPIC_RS10250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RPIC_RS10255	COG0444	Belongs to the ABC transporter superfamily
RPIC_RS10260	COG4608	Belongs to the ABC transporter superfamily
RPIC_RS10265	COG0747	negative chemotaxis
RPIC_RS10305	COG0840	transmembrane signaling receptor activity
RPIC_RS10320	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RPIC_RS10325	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPIC_RS10330	COG0697	spore germination
RPIC_RS10345	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RPIC_RS10350	COG1301	dicarboxylic acid transport
RPIC_RS10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC_RS10385	COG3154	lipid carrier protein
RPIC_RS10390	COG0826	peptidase U32
RPIC_RS10395	COG0826	peptidase U32
RPIC_RS10405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPIC_RS10430	COG3193	protein, possibly involved in utilization of glycolate and propanediol
RPIC_RS10465	COG1131	(ABC) transporter
RPIC_RS10470	COG0842	Transport permease protein
RPIC_RS10490	COG0285	dihydrofolate synthase activity
RPIC_RS10495	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RPIC_RS10500	COG0159	tryptophan synthase activity
RPIC_RS10510	COG0133	tryptophan synthase activity
RPIC_RS10515	COG0135	phosphoribosylanthranilate isomerase activity
RPIC_RS10520	COG0101	tRNA pseudouridine synthase activity
RPIC_RS10535	COG0473	3-isopropylmalate dehydrogenase activity
RPIC_RS10540	COG0066	3-isopropylmalate dehydratase activity
RPIC_RS10545	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPIC_RS10550	COG0372	Belongs to the citrate synthase family
RPIC_RS10555	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
RPIC_RS10560	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RPIC_RS10565	COG1053	succinate dehydrogenase
RPIC_RS10570	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
RPIC_RS10580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPIC_RS10585	COG0039	L-malate dehydrogenase activity
RPIC_RS10610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RPIC_RS10630	COG2866	Carboxypeptidase
RPIC_RS10635	COG3022	response to hydroperoxide
RPIC_RS10645	COG0436	Aminotransferase
RPIC_RS10650	COG0625	glutathione transferase activity
RPIC_RS10655	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPIC_RS10660	COG1024	Enoyl-CoA hydratase
RPIC_RS10680	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS10685	COG0583	DNA-binding transcription factor activity
RPIC_RS10700	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS10705	COG0625	glutathione transferase activity
RPIC_RS10720	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RPIC_RS10725	COG0830	nickel cation binding
RPIC_RS10730	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RPIC_RS10735	COG0804	urea catabolic process
RPIC_RS10740	COG0832	Belongs to the urease beta subunit family
RPIC_RS10750	COG0831	urea catabolic process
RPIC_RS10755	COG0829	nickel cation binding
RPIC_RS10765	COG0411	ABC transporter
RPIC_RS10790	COG1012	belongs to the aldehyde dehydrogenase family
RPIC_RS10790	COG2030	dehydratase
RPIC_RS10795	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS10800	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS10820	COG1007	ATP synthesis coupled electron transport
RPIC_RS10835	COG0713	ATP synthesis coupled electron transport
RPIC_RS10845	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC_RS10850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPIC_RS10855	COG1034	ATP synthesis coupled electron transport
RPIC_RS10870	COG0649	NAD binding
RPIC_RS10875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC_RS10880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC_RS10885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPIC_RS10895	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RPIC_RS10900	COG0149	triose-phosphate isomerase activity
RPIC_RS10915	COG1185	polyribonucleotide nucleotidyltransferase activity
RPIC_RS10920	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RPIC_RS10925	COG0683	leucine binding
RPIC_RS10935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPIC_RS10940	COG1183	phosphatidylcholine synthase activity
RPIC_RS10945	COG0688	phosphatidylethanolamine metabolic process
RPIC_RS10950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RPIC_RS10955	COG0440	acetolactate synthase activity
RPIC_RS10960	COG0028	Belongs to the TPP enzyme family
RPIC_RS10995	COG0438	transferase activity, transferring glycosyl groups
RPIC_RS11005	COG1309	transcriptional regulator
RPIC_RS11030	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
RPIC_RS11065	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RPIC_RS11070	COG0402	S-adenosylhomocysteine deaminase activity
RPIC_RS11075	COG2119	membrane
RPIC_RS11105	COG2351	hydroxyisourate hydrolase activity
RPIC_RS11115	COG2233	PERMEase
RPIC_RS11140	COG0280	phosphate acetyltransferase
RPIC_RS11140	COG0281	malic enzyme
RPIC_RS11150	COG0308	aminopeptidase N
RPIC_RS11155	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RPIC_RS11165	COG1652	LysM domain
RPIC_RS11185	COG0583	DNA-binding transcription factor activity
RPIC_RS11205	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPIC_RS11210	COG1758	RNA polymerase activity
RPIC_RS11215	COG0194	GDP metabolic process
RPIC_RS11220	COG1561	YicC-like family, N-terminal region
RPIC_RS11225	COG0515	serine threonine protein kinase
RPIC_RS11225	COG3064	Membrane
RPIC_RS11225	COG4991	sh3 domain protein
RPIC_RS11235	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RPIC_RS11240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RPIC_RS11245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPIC_RS11280	COG1705	Flagellar rod assembly protein muramidase FlgJ
RPIC_RS11280	COG3951	Flagellar rod assembly protein muramidase FlgJ
RPIC_RS11470	COG0305	Participates in initiation and elongation during chromosome replication
RPIC_RS11665	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RPIC_RS11685	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RPIC_RS11690	COG1984	allophanate hydrolase subunit 2
RPIC_RS11695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RPIC_RS11700	COG2814	Major facilitator Superfamily
RPIC_RS11705	COG3845	ABC transporter
RPIC_RS11710	COG4603	Belongs to the binding-protein-dependent transport system permease family
RPIC_RS11715	COG1079	Belongs to the binding-protein-dependent transport system permease family
RPIC_RS11735	COG1803	Methylglyoxal synthase
RPIC_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS11745	COG0697	spore germination
RPIC_RS11750	COG1953	Uracil, thiamine, allantoin
RPIC_RS11755	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RPIC_RS11760	COG0433	COG0433 Predicted ATPase
RPIC_RS11765	COG0217	transcriptional regulatory protein
RPIC_RS11770	COG0151	Belongs to the GarS family
RPIC_RS11775	COG0408	coproporphyrinogen oxidase activity
RPIC_RS11780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RPIC_RS11785	COG0799	negative regulation of ribosome biogenesis
RPIC_RS11790	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RPIC_RS11795	COG0424	maF-like protein
RPIC_RS11800	COG1530	ribonuclease E activity
RPIC_RS11810	COG1132	(ABC) transporter
RPIC_RS11820	COG0463	Glycosyl transferase, family 2
RPIC_RS11845	COG1054	Belongs to the UPF0176 family
RPIC_RS11855	COG1741	Belongs to the pirin family
RPIC_RS11860	COG0583	DNA-binding transcription factor activity
RPIC_RS11865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC_RS11870	COG0513	Belongs to the DEAD box helicase family
RPIC_RS11875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RPIC_RS11875	COG0426	domain, Protein
RPIC_RS11885	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS11890	COG0439	Biotin carboxylase
RPIC_RS11895	COG0683	leucine binding
RPIC_RS11900	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RPIC_RS11910	COG3047	cAMP biosynthetic process
RPIC_RS11945	COG2081	HI0933 family
RPIC_RS11950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RPIC_RS11955	COG1469	GTP cyclohydrolase I activity
RPIC_RS11960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPIC_RS11965	COG0142	geranyltranstransferase activity
RPIC_RS11970	COG1722	exodeoxyribonuclease VII activity
RPIC_RS11995	COG0412	Dienelactone hydrolase
RPIC_RS12000	COG1252	NADH dehydrogenase
RPIC_RS12005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIC_RS12005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPIC_RS12010	COG1611	Belongs to the LOG family
RPIC_RS12020	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RPIC_RS12030	COG0210	DNA helicase
RPIC_RS12035	COG0525	valine-tRNA ligase activity
RPIC_RS12040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RPIC_RS12050	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RPIC_RS12060	COG2342	PFAM TM1410 hypothetical-related protein
RPIC_RS12075	COG0683	leucine binding
RPIC_RS12085	COG0411	ABC transporter
RPIC_RS12100	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS12105	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIC_RS12115	COG0183	Belongs to the thiolase family
RPIC_RS12120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
RPIC_RS12130	COG1414	Transcriptional regulator
RPIC_RS12140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC_RS12145	COG0765	amino acid transport
RPIC_RS12150	COG0765	amino acid transport
RPIC_RS12165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPIC_RS12205	COG1253	flavin adenine dinucleotide binding
RPIC_RS12210	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS12215	COG0789	Transcriptional regulator
RPIC_RS12255	COG3284	Transcriptional regulator
RPIC_RS12270	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RPIC_RS12275	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RPIC_RS12285	COG0535	radical SAM domain protein
RPIC_RS12340	COG0204	Acyl-transferase
RPIC_RS12375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC_RS12385	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RPIC_RS12405	COG2181	nitrate reductase activity
RPIC_RS12410	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RPIC_RS12415	COG1140	nitrate reductase beta subunit
RPIC_RS12420	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RPIC_RS12425	COG2801	Transposase and inactivated derivatives
RPIC_RS12430	COG2860	membrane
RPIC_RS12435	COG1473	amidohydrolase
RPIC_RS12455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIC_RS12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC_RS12475	COG0346	lactoylglutathione lyase activity
RPIC_RS12495	COG4654	Cytochrome c, class I
RPIC_RS12550	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPIC_RS12560	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RPIC_RS12565	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RPIC_RS12580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RPIC_RS12585	COG1674	ftsk spoiiie
RPIC_RS12590	COG0492	ferredoxin-NADP+ reductase activity
RPIC_RS12595	COG1193	negative regulation of DNA recombination
RPIC_RS12605	COG0347	Belongs to the P(II) protein family
RPIC_RS12630	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RPIC_RS12645	COG2271	Major facilitator Superfamily
RPIC_RS12660	COG0181	hydroxymethylbilane synthase activity
RPIC_RS12665	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RPIC_RS12690	COG0165	Argininosuccinate lyase
RPIC_RS12700	COG0717	Belongs to the dCTP deaminase family
RPIC_RS12705	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RPIC_RS12710	COG2032	superoxide dismutase activity
RPIC_RS12730	COG0437	4 iron, 4 sulfur cluster binding
RPIC_RS12735	COG3383	formate dehydrogenase (NAD+) activity
RPIC_RS12735	COG0243	molybdopterin cofactor binding
RPIC_RS12765	COG0489	protein tyrosine kinase activity
RPIC_RS12770	COG2885	chlorophyll binding
RPIC_RS12770	COG3047	cAMP biosynthetic process
RPIC_RS12775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC_RS12775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPIC_RS12785	COG2911	Protein conserved in bacteria
RPIC_RS12790	COG0729	surface antigen
RPIC_RS12800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RPIC_RS12805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RPIC_RS12815	COG4804	nuclease activity
RPIC_RS12880	COG5489	Protein of unknown function (DUF736)
RPIC_RS12910	COG1192	Involved in chromosome partitioning
RPIC_RS12925	COG4959	Type IV secretory pathway protease TraF
RPIC_RS12945	COG1024	Enoyl-CoA hydratase
RPIC_RS12950	COG0183	Belongs to the thiolase family
RPIC_RS12955	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS12960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS12985	COG2814	Major facilitator Superfamily
RPIC_RS12990	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS13005	COG0583	DNA-binding transcription factor activity
RPIC_RS13025	COG4962	Type ii secretion system protein e
RPIC_RS13030	COG3838	Conjugal transfer protein Trbc
RPIC_RS13040	COG3451	type IV secretory pathway VirB4
RPIC_RS13080	COG1492	cobalamin metabolic process
RPIC_RS13110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RPIC_RS13115	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RPIC_RS13125	COG1120	ATPase activity
RPIC_RS13135	COG4206	TonB-dependent receptor
RPIC_RS13170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RPIC_RS13175	COG0583	DNA-binding transcription factor activity
RPIC_RS13180	COG0129	dihydroxy-acid dehydratase activity
RPIC_RS13195	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPIC_RS13225	COG2895	sulfate adenylyltransferase (ATP) activity
RPIC_RS13235	COG0175	sulfate reduction
RPIC_RS13245	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPIC_RS13250	COG0730	response to heat
RPIC_RS13255	COG0583	DNA-binding transcription factor activity
RPIC_RS13265	COG2084	Dehydrogenase
RPIC_RS13280	COG0656	L-ascorbic acid biosynthetic process
RPIC_RS13285	COG2814	Major facilitator Superfamily
RPIC_RS13315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPIC_RS13350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPIC_RS13355	COG1047	Peptidyl-prolyl cis-trans
RPIC_RS13360	COG2003	Belongs to the UPF0758 family
RPIC_RS13365	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RPIC_RS13370	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RPIC_RS13375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RPIC_RS13385	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RPIC_RS13395	COG1511	domain protein
RPIC_RS13395	COG3264	Mechanosensitive ion channel
RPIC_RS13400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RPIC_RS13405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RPIC_RS13405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPIC_RS13410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RPIC_RS13425	COG0196	riboflavin kinase activity
RPIC_RS13430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RPIC_RS13435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RPIC_RS13450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RPIC_RS13455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPIC_RS13460	COG0756	dUTP diphosphatase activity
RPIC_RS13465	COG0542	response to heat
RPIC_RS13470	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPIC_RS13475	COG1278	Cold shock
RPIC_RS13550	COG0582	viral genome integration into host DNA
RPIC_RS13590	COG3895	Periplasmic Protein
RPIC_RS13595	COG0583	DNA-binding transcription factor activity
RPIC_RS13615	COG2259	Doxx family
RPIC_RS13650	COG2321	neutral zinc metallopeptidase
RPIC_RS13655	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS13665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC_RS13740	COG2610	gluconate transmembrane transporter activity
RPIC_RS13765	COG0010	Belongs to the arginase family
RPIC_RS13770	COG1126	abc transporter atp-binding protein
RPIC_RS13775	COG0765	amino acid transport
RPIC_RS13780	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPIC_RS13810	COG1570	exodeoxyribonuclease VII activity
RPIC_RS13815	COG0811	peptide transport
RPIC_RS13825	COG1663	tetraacyldisaccharide 4'-kinase activity
RPIC_RS13830	COG2835	tetraacyldisaccharide 4'-kinase activity
RPIC_RS13835	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RPIC_RS13840	COG0563	adenylate kinase activity
RPIC_RS13850	COG0583	DNA-binding transcription factor activity
RPIC_RS13865	COG0860	N-Acetylmuramoyl-L-alanine amidase
RPIC_RS13870	COG0802	atpase or kinase
RPIC_RS13875	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RPIC_RS13890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC_RS13895	COG4974	Belongs to the 'phage' integrase family
RPIC_RS13900	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RPIC_RS13905	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RPIC_RS13915	COG2366	antibiotic biosynthetic process
RPIC_RS13920	COG1666	GTP binding
RPIC_RS13925	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RPIC_RS13930	COG3123	guanosine phosphorylase activity
RPIC_RS13935	COG0137	argininosuccinate synthase activity
RPIC_RS13940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RPIC_RS13950	COG0268	Binds directly to 16S ribosomal RNA
RPIC_RS13955	COG0728	peptidoglycan biosynthetic process
RPIC_RS13965	COG0586	Pfam SNARE associated Golgi protein
RPIC_RS13970	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RPIC_RS13975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RPIC_RS13980	COG0456	acetyltransferase
RPIC_RS14010	COG0243	molybdopterin cofactor binding
RPIC_RS14015	COG3043	anaerobic respiration
RPIC_RS14020	COG3005	denitrification pathway
RPIC_RS14025	COG4133	protoheme IX ABC transporter activity
RPIC_RS14040	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RPIC_RS14050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIC_RS14065	COG2169	Transcriptional regulator
RPIC_RS14065	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPIC_RS14080	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RPIC_RS14085	COG0628	permease
RPIC_RS14105	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RPIC_RS14115	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RPIC_RS14120	COG4662	Binding-protein-dependent transport system inner membrane component
RPIC_RS14125	COG3842	ATPase activity
RPIC_RS14130	COG0512	Glutamine amidotransferase of anthranilate synthase
RPIC_RS14130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RPIC_RS14135	COG0484	heat shock protein binding
RPIC_RS14140	COG0443	Heat shock 70 kDa protein
RPIC_RS14150	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPIC_RS14160	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPIC_RS14175	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RPIC_RS14180	COG1228	amidohydrolase
RPIC_RS14185	COG0010	Belongs to the arginase family
RPIC_RS14190	COG2986	histidine ammonia-lyase
RPIC_RS14195	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RPIC_RS14205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPIC_RS14215	COG4521	taurine ABC transporter
RPIC_RS14220	COG1420	regulation of RNA biosynthetic process
RPIC_RS14225	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RPIC_RS14230	COG0497	DNA recombination
RPIC_RS14240	COG1404	Belongs to the peptidase S8 family
RPIC_RS14245	COG1404	Belongs to the peptidase S8 family
RPIC_RS14255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RPIC_RS14270	COG0312	modulator of DNA gyrase
RPIC_RS14275	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RPIC_RS14280	COG0668	transmembrane transport
RPIC_RS14285	COG2096	Adenosyltransferase
RPIC_RS14290	COG0277	FAD linked oxidase domain protein
RPIC_RS14295	COG0583	DNA-binding transcription factor activity
RPIC_RS14300	COG0277	FAD linked oxidase domain protein
RPIC_RS14305	COG0277	FAD linked oxidase domain protein
RPIC_RS14310	COG0247	lactate metabolic process
RPIC_RS14315	COG1380	Effector of murein hydrolase LrgA
RPIC_RS14320	COG1346	cytolysis
RPIC_RS14340	COG0386	Belongs to the glutathione peroxidase family
RPIC_RS14395	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RPIC_RS14400	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RPIC_RS14405	COG0783	Belongs to the Dps family
RPIC_RS14415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPIC_RS14470	COG1230	cation diffusion facilitator family transporter
RPIC_RS14490	COG0745	RESPONSE REGULATOR receiver
RPIC_RS14500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS14545	COG1408	metallophosphoesterase
RPIC_RS14550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RPIC_RS14555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RPIC_RS14560	COG0343	queuine tRNA-ribosyltransferase activity
RPIC_RS14565	COG1862	Preprotein translocase
RPIC_RS14585	COG2353	YceI-like domain
RPIC_RS14590	COG3038	cytochrome b561
RPIC_RS14600	COG0625	glutathione transferase activity
RPIC_RS14605	COG0069	glutamate synthase activity
RPIC_RS14610	COG0482	sulfurtransferase activity
RPIC_RS14625	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RPIC_RS14650	COG4191	Histidine kinase
RPIC_RS14655	COG4191	Histidine kinase
RPIC_RS14660	COG2204	response regulator
RPIC_RS14670	COG1981	membrane
RPIC_RS14675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RPIC_RS14690	COG0495	leucyl-tRNA aminoacylation
RPIC_RS14695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RPIC_RS14700	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RPIC_RS14705	COG0735	belongs to the Fur family
RPIC_RS14710	COG0583	DNA-binding transcription factor activity
RPIC_RS14715	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RPIC_RS14720	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RPIC_RS14725	COG4948	Mandelate Racemase Muconate Lactonizing
RPIC_RS14730	COG0800	Aldolase
RPIC_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS14750	COG1172	Belongs to the binding-protein-dependent transport system permease family
RPIC_RS14755	COG1129	ABC transporter
RPIC_RS14770	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS14775	COG0583	DNA-binding transcription factor activity
RPIC_RS14785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RPIC_RS14840	COG0281	malic enzyme
RPIC_RS14840	COG0280	phosphate acetyltransferase
RPIC_RS14850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RPIC_RS14855	COG1546	Belongs to the CinA family
RPIC_RS14855	COG1058	Belongs to the CinA family
RPIC_RS14865	COG0284	orotidine-5'-phosphate decarboxylase activity
RPIC_RS14875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RPIC_RS14880	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RPIC_RS14890	COG0557	exoribonuclease II activity
RPIC_RS14895	COG3161	chorismate lyase activity
RPIC_RS14900	COG3150	esterase
RPIC_RS14905	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIC_RS14915	COG3118	belongs to the thioredoxin family
RPIC_RS14920	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RPIC_RS14925	COG0511	ligase activity, forming carbon-carbon bonds
RPIC_RS14935	COG2264	protein methyltransferase activity
RPIC_RS14945	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RPIC_RS14950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPIC_RS14985	COG0840	transmembrane signaling receptor activity
RPIC_RS15055	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RPIC_RS15060	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RPIC_RS15065	COG2095	MarC family integral membrane protein
RPIC_RS15075	COG0741	lytic transglycosylase activity
RPIC_RS15080	COG0442	prolyl-tRNA aminoacylation
RPIC_RS15085	COG0494	nUDIX hydrolase
RPIC_RS15095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RPIC_RS15100	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPIC_RS15105	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RPIC_RS15110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RPIC_RS15115	COG0142	geranyltranstransferase activity
RPIC_RS15125	COG4536	flavin adenine dinucleotide binding
RPIC_RS15145	COG0237	dephospho-CoA kinase activity
RPIC_RS15150	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
RPIC_RS15155	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RPIC_RS15160	COG0494	nUDIX hydrolase
RPIC_RS15170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RPIC_RS15175	COG0653	protein targeting
RPIC_RS15180	COG0739	heme binding
RPIC_RS15190	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RPIC_RS15195	COG0678	peroxiredoxin activity
RPIC_RS15210	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RPIC_RS15215	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPIC_RS15220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPIC_RS15225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RPIC_RS15235	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RPIC_RS15240	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPIC_RS15245	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RPIC_RS15250	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RPIC_RS15260	COG3116	cell division
RPIC_RS15265	COG0275	rRNA processing
RPIC_RS15270	COG2001	Belongs to the MraZ family
RPIC_RS15275	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
RPIC_RS15280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS15285	COG0477	Major facilitator Superfamily
RPIC_RS15295	COG1272	protein, Hemolysin III
RPIC_RS15300	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS15310	COG0243	molybdopterin cofactor binding
RPIC_RS15315	COG1609	Transcriptional regulator
RPIC_RS15320	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPIC_RS15320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPIC_RS15325	COG1105	Belongs to the carbohydrate kinase PfkB family
RPIC_RS15330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RPIC_RS15330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
RPIC_RS15340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC_RS15345	COG1473	amidohydrolase
RPIC_RS15375	COG1024	Enoyl-CoA hydratase
RPIC_RS15380	COG1024	Enoyl-CoA hydratase
RPIC_RS15385	COG2050	protein possibly involved in aromatic compounds catabolism
RPIC_RS15405	COG2967	ApaG domain
RPIC_RS15410	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RPIC_RS15415	COG0546	phosphoglycolate phosphatase activity
RPIC_RS15425	COG0512	Glutamine amidotransferase of anthranilate synthase
RPIC_RS15435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPIC_RS15440	COG0134	indole-3-glycerol-phosphate synthase activity
RPIC_RS15450	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RPIC_RS15455	COG1289	transmembrane transporter activity
RPIC_RS15460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC_RS15465	COG0604	alcohol dehydrogenase
RPIC_RS15475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPIC_RS15500	COG0012	GTP binding
RPIC_RS15505	COG4251	negative regulation of phosphorylation
RPIC_RS15510	COG0784	Response regulator, receiver
RPIC_RS15515	COG2205	protein histidine kinase activity
RPIC_RS15515	COG3437	response regulator, receiver
RPIC_RS15515	COG4999	Histidine kinase
RPIC_RS15515	COG3850	Histidine kinase
RPIC_RS15525	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RPIC_RS15530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RPIC_RS15540	COG2890	protein-(glutamine-N5) methyltransferase activity
RPIC_RS15550	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RPIC_RS15565	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RPIC_RS15570	COG3416	Protein conserved in bacteria
RPIC_RS15570	COG2943	transferase activity, transferring hexosyl groups
RPIC_RS15590	COG0488	(ABC) transporter
RPIC_RS15595	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
RPIC_RS15610	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPIC_RS15640	COG3093	addiction module antidote protein HigA
RPIC_RS15650	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RPIC_RS15660	COG0210	DNA helicase
RPIC_RS15680	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RPIC_RS15755	COG5314	conjugation
RPIC_RS15800	COG2969	positive regulation of protein catabolic process
RPIC_RS15805	COG0625	glutathione transferase activity
RPIC_RS15810	COG2857	Cytochrome c1
RPIC_RS15815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RPIC_RS15820	COG0723	plastoquinol--plastocyanin reductase activity
RPIC_RS15825	COG1970	mechanosensitive ion channel activity
RPIC_RS15830	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RPIC_RS15835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC_RS15845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS15860	COG0642	Histidine kinase
RPIC_RS15865	COG1840	ABC-type Fe3 transport system, periplasmic component
RPIC_RS15875	COG3842	ATPase activity
RPIC_RS15880	COG0805	protein transport
RPIC_RS15885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIC_RS15890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPIC_RS15900	COG0140	phosphoribosyl-ATP diphosphatase activity
RPIC_RS15905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RPIC_RS15910	COG0107	imidazoleglycerol-phosphate synthase activity
RPIC_RS15915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RPIC_RS15920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RPIC_RS15925	COG2095	MarC family integral membrane protein
RPIC_RS15930	COG0131	Imidazoleglycerol-phosphate dehydratase
RPIC_RS15935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPIC_RS15940	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RPIC_RS15945	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RPIC_RS15950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RPIC_RS15960	COG0842	Transport permease protein
RPIC_RS15965	COG1131	(ABC) transporter
RPIC_RS15985	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPIC_RS15990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RPIC_RS15995	COG1127	ABC transporter
RPIC_RS16010	COG0067	glutamate synthase
RPIC_RS16010	COG0070	glutamate synthase
RPIC_RS16010	COG0069	glutamate synthase activity
RPIC_RS16020	COG3047	cAMP biosynthetic process
RPIC_RS16025	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RPIC_RS16030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RPIC_RS16035	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPIC_RS16070	COG1965	Belongs to the frataxin family
RPIC_RS16085	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RPIC_RS16090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPIC_RS16110	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPIC_RS16115	COG1333	cytochrome c biogenesis protein
RPIC_RS16125	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RPIC_RS16135	COG4232	protein-disulfide reductase activity
RPIC_RS16145	COG0203	ribosomal protein L17
RPIC_RS16150	COG0202	RNA polymerase activity
RPIC_RS16155	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RPIC_RS16160	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RPIC_RS16165	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPIC_RS16170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RPIC_RS16180	COG0201	protein transport
RPIC_RS16185	COG0200	Binds to the 23S rRNA
RPIC_RS16190	COG1841	ribosomal large subunit assembly
RPIC_RS16195	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RPIC_RS16200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RPIC_RS16205	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RPIC_RS16210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RPIC_RS16215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RPIC_RS16220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPIC_RS16225	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RPIC_RS16230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RPIC_RS16235	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RPIC_RS16240	COG0255	Belongs to the universal ribosomal protein uL29 family
RPIC_RS16245	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RPIC_RS16250	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RPIC_RS16255	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RPIC_RS16260	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RPIC_RS16265	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPIC_RS16270	COG0089	rRNA binding
RPIC_RS16275	COG0088	Forms part of the polypeptide exit tunnel
RPIC_RS16280	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RPIC_RS16285	COG0051	transcription antitermination factor activity, RNA binding
RPIC_RS16290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIC_RS16295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPIC_RS16300	COG0049	tRNA binding
RPIC_RS16305	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RPIC_RS16310	COG2814	Major facilitator Superfamily
RPIC_RS16315	COG0583	DNA-binding transcription factor activity
RPIC_RS16320	COG0514	ATP-dependent DNA helicase (RecQ)
RPIC_RS16330	COG4676	Protein conserved in bacteria
RPIC_RS16335	COG4676	Protein conserved in bacteria
RPIC_RS16340	COG5445	Predicted secreted protein (DUF2300)
RPIC_RS16345	COG2373	Large extracellular alpha-helical protein
RPIC_RS16350	COG3234	Protein of unknown function (DUF1175)
RPIC_RS16355	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
RPIC_RS16360	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RPIC_RS16365	COG0085	RNA polymerase activity
RPIC_RS16370	COG0222	ribosome binding
RPIC_RS16375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RPIC_RS16380	COG0081	regulation of translation
RPIC_RS16385	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RPIC_RS16405	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPIC_RS16425	COG2433	Pfam Transposase IS66
RPIC_RS16480	COG3842	ATPase activity
RPIC_RS16485	COG3842	ATPase activity
RPIC_RS16495	COG0395	ABC-type sugar transport system, permease component
RPIC_RS16510	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RPIC_RS16525	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RPIC_RS16575	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS16580	COG0668	transmembrane transport
RPIC_RS16585	COG2814	Major facilitator Superfamily
RPIC_RS16625	COG2197	response regulator
RPIC_RS16630	COG0784	Response regulator, receiver
RPIC_RS16630	COG2205	protein histidine kinase activity
RPIC_RS16655	COG0789	Transcriptional regulator
RPIC_RS16675	COG3245	cytochrome
RPIC_RS16695	COG0745	RESPONSE REGULATOR receiver
RPIC_RS16705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS16715	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RPIC_RS16720	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
RPIC_RS16725	COG2080	2 iron, 2 sulfur cluster binding
RPIC_RS16770	COG1522	sequence-specific DNA binding
RPIC_RS16800	COG2165	general secretion pathway protein
RPIC_RS16860	COG2925	Exonuclease
RPIC_RS16865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPIC_RS16875	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPIC_RS16885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
RPIC_RS16890	COG2197	response regulator
RPIC_RS16895	COG0840	transmembrane signaling receptor activity
RPIC_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
RPIC_RS16925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPIC_RS16940	COG0477	Major facilitator Superfamily
RPIC_RS16945	COG0671	phosphoesterase, PA-phosphatase related
RPIC_RS16970	COG0459	protein refolding
RPIC_RS17030	COG0657	acetylesterase activity
RPIC_RS17050	COG1846	Transcriptional regulator
RPIC_RS17055	COG1764	response to oxidative stress
RPIC_RS17065	COG0443	Heat shock 70 kDa protein
RPIC_RS17095	COG0737	Belongs to the 5'-nucleotidase family
RPIC_RS17100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPIC_RS17105	COG2010	Cytochrome c
RPIC_RS17130	COG4654	Cytochrome c, class I
RPIC_RS17140	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPIC_RS17150	COG2823	Periplasmic or secreted lipoprotein
RPIC_RS17155	COG0792	nuclease activity
RPIC_RS17170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPIC_RS17185	COG1393	Belongs to the ArsC family
RPIC_RS17190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC_RS17200	COG4266	Belongs to the allantoicase family
RPIC_RS17205	COG1301	dicarboxylic acid transport
RPIC_RS17215	COG1739	Uncharacterized protein family UPF0029
RPIC_RS17225	COG0583	DNA-binding transcription factor activity
RPIC_RS17230	COG3960	tartronate-semialdehyde synthase activity
RPIC_RS17235	COG3622	Belongs to the hyi family
RPIC_RS17245	COG2084	Dehydrogenase
RPIC_RS17255	COG0469	pyruvate kinase activity
RPIC_RS17260	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPIC_RS17270	COG0210	DNA helicase
RPIC_RS17280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RPIC_RS17285	COG0509	glycine decarboxylation via glycine cleavage system
RPIC_RS17290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIC_RS17290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPIC_RS17295	COG1760	l-serine dehydratase
RPIC_RS17300	COG1297	OPT oligopeptide transporter protein
RPIC_RS17310	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RPIC_RS17320	COG0683	leucine binding
RPIC_RS17325	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIC_RS17325	COG0506	proline dehydrogenase activity
RPIC_RS17325	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RPIC_RS17330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RPIC_RS17335	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RPIC_RS17350	COG0840	transmembrane signaling receptor activity
RPIC_RS17385	COG1832	CoA-binding protein
RPIC_RS17400	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RPIC_RS17405	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RPIC_RS17410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RPIC_RS17415	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RPIC_RS17420	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RPIC_RS17425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPIC_RS17435	COG0356	it plays a direct role in the translocation of protons across the membrane
RPIC_RS17445	COG1475	DNA binding
RPIC_RS17450	COG1192	Involved in chromosome partitioning
RPIC_RS17455	COG0357	Ribosomal RNA small subunit methyltransferase G
RPIC_RS17460	COG0445	tRNA wobble uridine modification
RPIC_RS17485	COG3530	Putative quorum-sensing-regulated virulence factor
RPIC_RS17490	COG0583	DNA-binding transcription factor activity
RPIC_RS17545	COG0411	ABC transporter
RPIC_RS17550	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RPIC_RS17555	COG2267	carboxylic ester hydrolase activity
RPIC_RS17560	COG0789	Transcriptional regulator
RPIC_RS17565	COG2217	Heavy metal translocating P-type atpase
RPIC_RS17575	COG3047	cAMP biosynthetic process
RPIC_RS17580	COG2423	ornithine cyclodeaminase activity
RPIC_RS17595	COG3186	Phenylalanine-4-hydroxylase
RPIC_RS17600	COG2154	pterin-4-alpha-carbinolamine dehydratase
RPIC_RS17615	COG0642	Histidine kinase
RPIC_RS17640	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPIC_RS17650	COG0737	Belongs to the 5'-nucleotidase family
RPIC_RS17655	COG0850	regulation of cytokinetic process
RPIC_RS17660	COG2894	cell division
RPIC_RS17665	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RPIC_RS17675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPIC_RS17680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RPIC_RS17690	COG1254	Belongs to the acylphosphatase family
RPIC_RS17700	COG1116	anion transmembrane transporter activity
RPIC_RS17740	COG0346	lactoylglutathione lyase activity
RPIC_RS17745	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RPIC_RS17750	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RPIC_RS17780	COG2357	RelA SpoT domain protein
RPIC_RS17800	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RPIC_RS17805	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RPIC_RS17810	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RPIC_RS17815	COG2205	protein histidine kinase activity
RPIC_RS17825	COG2199	diguanylate cyclase activity
RPIC_RS17825	COG2200	EAL domain
RPIC_RS17830	COG2197	response regulator
RPIC_RS17840	COG0477	Major facilitator Superfamily
RPIC_RS17850	COG1335	isochorismatase
RPIC_RS17865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPIC_RS17890	COG1959	2 iron, 2 sulfur cluster binding
RPIC_RS17910	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPIC_RS17935	COG3257	ureidoglycine aminohydrolase activity
RPIC_RS17950	COG4106	trans-aconitate 2-methyltransferase activity
RPIC_RS17970	COG0642	Histidine kinase
RPIC_RS18025	COG0583	DNA-binding transcription factor activity
RPIC_RS18040	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS18050	COG2070	2-Nitropropane dioxygenase
RPIC_RS18055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RPIC_RS18070	COG2022	thiamine diphosphate biosynthetic process
RPIC_RS18080	COG2764	glyoxalase bleomycin resistance protein dioxygenase
RPIC_RS18100	COG0351	phosphomethylpyrimidine kinase
RPIC_RS18120	COG1785	Belongs to the alkaline phosphatase family
RPIC_RS18130	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RPIC_RS18135	COG1950	PFAM Membrane protein of
RPIC_RS18140	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RPIC_RS18155	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RPIC_RS18175	COG0617	tRNA 3'-terminal CCA addition
RPIC_RS18185	COG3246	L-lysine catabolic process to acetate
RPIC_RS18190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RPIC_RS18210	COG2204	response regulator
RPIC_RS18215	COG5000	phosphorelay sensor kinase activity
RPIC_RS18230	COG0501	Belongs to the peptidase M48B family
RPIC_RS18240	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPIC_RS18250	COG0242	peptide deformylase activity
RPIC_RS18255	COG1652	LysM domain
RPIC_RS18260	COG0758	DNA mediated transformation
RPIC_RS18275	COG0583	DNA-binding transcription factor activity
RPIC_RS18280	COG0318	PFAM AMP-dependent synthetase and ligase
RPIC_RS18285	COG0772	Belongs to the SEDS family
RPIC_RS18290	COG0768	penicillin binding
RPIC_RS18300	COG1792	Involved in formation and maintenance of cell shape
RPIC_RS18305	COG1077	Cell shape determining protein MreB Mrl
RPIC_RS18310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIC_RS18315	COG0154	amidase activity
RPIC_RS18330	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPIC_RS18340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RPIC_RS18345	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RPIC_RS18360	COG2706	6-phosphogluconolactonase activity
RPIC_RS18370	COG0523	cobalamin synthesis protein
RPIC_RS18385	COG0747	negative chemotaxis
RPIC_RS18390	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RPIC_RS18395	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RPIC_RS18410	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RPIC_RS18435	COG1595	DNA-templated transcription, initiation
RPIC_RS18440	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPIC_RS18460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RPIC_RS18470	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPIC_RS18485	COG2879	small protein
RPIC_RS18490	COG1966	Carbon starvation protein
RPIC_RS18505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPIC_RS18510	COG2186	Transcriptional regulator
RPIC_RS18515	COG2084	Dehydrogenase
RPIC_RS18520	COG3395	kinase activity
RPIC_RS18525	COG0235	Class ii aldolase
RPIC_RS18530	COG2271	Major facilitator Superfamily
RPIC_RS18535	COG3622	Belongs to the hyi family
RPIC_RS18545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
RPIC_RS18550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPIC_RS18555	COG3384	dioxygenase
RPIC_RS18560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPIC_RS18570	COG1309	transcriptional regulator
RPIC_RS18575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPIC_RS18580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPIC_RS18595	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RPIC_RS18615	COG0494	nUDIX hydrolase
RPIC_RS18620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RPIC_RS18630	COG0706	membrane insertase activity
RPIC_RS18635	COG0594	ribonuclease P activity
RPIC_RS18640	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RPIC_RS19205	COG1960	acyl-CoA dehydrogenase activity
RPIC_RS19250	COG4770	biotin carboxylase activity
RPIC_RS19285	COG3012	SEC-C Motif Domain Protein
RPIC_RS20015	COG0535	radical SAM domain protein
RPIC_RS20185	COG4178	(ABC) transporter
RPIC_RS20335	COG5265	(ABC) transporter
RPIC_RS20535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPIC_RS20580	COG0751	glycine-tRNA ligase activity
RPIC_RS20675	COG0513	Belongs to the DEAD box helicase family
RPIC_RS20975	COG0126	phosphoglycerate kinase activity
RPIC_RS21305	COG3395	kinase activity
RPIC_RS21625	COG0463	Glycosyl transferase, family 2
RPIC_RS22040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPIC_RS22170	COG3188	usher protein
RPIC_RS22445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPIC_RS23010	COG0322	excinuclease ABC activity
RPIC_RS23075	COG1501	Belongs to the glycosyl hydrolase 31 family
RPIC_RS23310	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPIC_RS23330	COG0215	cysteine-tRNA ligase activity
RPIC_RS23670	COG1160	GTP binding
RPIC_RS23730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPIC_RS23845	COG3842	ATPase activity
RPIC_RS23975	COG2814	Major facilitator Superfamily
RPIC_RS24160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RPIC_RS24270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPIC_RS24310	COG0306	phosphate transporter
RPIC_RS24455	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPIC_RS24770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity