locus-tag	class	description
CDC46_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDC46_RS00010	COG0594	ribonuclease P activity
CDC46_RS00015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDC46_RS00020	COG0706	membrane insertase activity
CDC46_RS00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC46_RS00040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDC46_RS00050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC46_RS00055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS00060	COG1309	transcriptional regulator
CDC46_RS00070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC46_RS00075	COG3384	dioxygenase
CDC46_RS00080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC46_RS00090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CDC46_RS00095	COG0745	RESPONSE REGULATOR receiver
CDC46_RS00105	COG3622	Belongs to the hyi family
CDC46_RS00120	COG1966	Carbon starvation protein
CDC46_RS00125	COG2879	small protein
CDC46_RS00145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC46_RS00155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDC46_RS00175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC46_RS00180	COG1595	DNA-templated transcription, initiation
CDC46_RS00210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CDC46_RS00220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CDC46_RS00225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CDC46_RS00230	COG0747	negative chemotaxis
CDC46_RS00245	COG0523	cobalamin synthesis protein
CDC46_RS00265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CDC46_RS00270	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC46_RS00280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC46_RS00295	COG0154	amidase activity
CDC46_RS00300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC46_RS00305	COG1077	Cell shape determining protein MreB Mrl
CDC46_RS00310	COG1792	Involved in formation and maintenance of cell shape
CDC46_RS00320	COG0768	penicillin binding
CDC46_RS00325	COG0772	Belongs to the SEDS family
CDC46_RS00330	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS00335	COG0583	DNA-binding transcription factor activity
CDC46_RS00350	COG0758	DNA mediated transformation
CDC46_RS00355	COG1652	LysM domain
CDC46_RS00360	COG0242	peptide deformylase activity
CDC46_RS00370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC46_RS00380	COG0501	Belongs to the peptidase M48B family
CDC46_RS00385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC46_RS00395	COG5000	phosphorelay sensor kinase activity
CDC46_RS00400	COG2204	response regulator
CDC46_RS00425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC46_RS00430	COG3246	L-lysine catabolic process to acetate
CDC46_RS00440	COG0617	tRNA 3'-terminal CCA addition
CDC46_RS00445	COG0625	glutathione transferase activity
CDC46_RS00455	COG0741	lytic transglycosylase activity
CDC46_RS00460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDC46_RS00470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDC46_RS00475	COG1950	PFAM Membrane protein of
CDC46_RS00480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDC46_RS00495	COG1785	Belongs to the alkaline phosphatase family
CDC46_RS00500	COG1785	Belongs to the alkaline phosphatase family
CDC46_RS00550	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CDC46_RS00560	COG2022	thiamine diphosphate biosynthetic process
CDC46_RS00580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDC46_RS00585	COG2070	2-Nitropropane dioxygenase
CDC46_RS00655	COG1522	sequence-specific DNA binding
CDC46_RS00665	COG0516	GMP reductase activity
CDC46_RS00665	COG0517	IMP dehydrogenase activity
CDC46_RS00685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDC46_RS00695	COG1560	Kdo2-lipid A biosynthetic process
CDC46_RS00700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDC46_RS00705	COG2326	polyphosphate kinase activity
CDC46_RS00710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDC46_RS00715	COG0708	Exodeoxyribonuclease III
CDC46_RS00720	COG4682	membrane
CDC46_RS00725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDC46_RS00745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CDC46_RS00770	COG0697	spore germination
CDC46_RS00780	COG0501	Belongs to the peptidase M48B family
CDC46_RS00785	COG2223	nitrite transmembrane transporter activity
CDC46_RS00810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC46_RS00815	COG0583	DNA-binding transcription factor activity
CDC46_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS00830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS00835	COG1131	(ABC) transporter
CDC46_RS00840	COG0842	Transport permease protein
CDC46_RS00855	COG0493	'glutamate synthase
CDC46_RS00880	COG0546	phosphoglycolate phosphatase activity
CDC46_RS00880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC46_RS00885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC46_RS00890	COG0037	tRNA processing
CDC46_RS00900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDC46_RS00905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDC46_RS00915	COG0589	response to stress
CDC46_RS00935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CDC46_RS00940	COG0589	response to stress
CDC46_RS00970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC46_RS00975	COG3851	Histidine kinase
CDC46_RS00980	COG2197	response regulator
CDC46_RS00990	COG1063	alcohol dehydrogenase
CDC46_RS00995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDC46_RS01015	COG3038	cytochrome b561
CDC46_RS01030	COG0071	Belongs to the small heat shock protein (HSP20) family
CDC46_RS01035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDC46_RS01040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC46_RS01050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CDC46_RS01105	COG1733	regulation of RNA biosynthetic process
CDC46_RS01120	COG0519	Catalyzes the synthesis of GMP from XMP
CDC46_RS01120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC46_RS01125	COG0583	DNA-binding transcription factor activity
CDC46_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS01135	COG2814	Major facilitator Superfamily
CDC46_RS01140	COG0667	Aldo Keto reductase
CDC46_RS01150	COG1254	Belongs to the acylphosphatase family
CDC46_RS01165	COG4650	regulator
CDC46_RS01175	COG1690	Belongs to the RtcB family
CDC46_RS01180	COG3541	Predicted nucleotidyltransferase
CDC46_RS01185	COG0430	RNA-3'-phosphate cyclase activity
CDC46_RS01195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS01240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC46_RS01240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC46_RS01240	COG1703	isobutyryl-CoA mutase activity
CDC46_RS01270	COG0583	DNA-binding transcription factor activity
CDC46_RS01275	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC46_RS01320	COG3328	transposase activity
CDC46_RS01340	COG0596	Alpha beta hydrolase
CDC46_RS01370	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC46_RS01385	COG4770	biotin carboxylase activity
CDC46_RS01400	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDC46_RS01405	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDC46_RS01415	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDC46_RS01420	COG3012	SEC-C Motif Domain Protein
CDC46_RS01425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC46_RS01440	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS01445	COG0300	oxidoreductase activity
CDC46_RS01450	COG0183	Belongs to the thiolase family
CDC46_RS01465	COG0288	reversible hydration of carbon dioxide
CDC46_RS01470	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CDC46_RS01475	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS01480	COG0789	Transcriptional regulator
CDC46_RS01490	COG2329	Antibiotic biosynthesis monooxygenase
CDC46_RS01500	COG4221	oxidoreductase activity
CDC46_RS01505	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDC46_RS01515	COG0018	arginyl-trna synthetase
CDC46_RS01540	COG2197	response regulator
CDC46_RS01570	COG2267	carboxylic ester hydrolase activity
CDC46_RS01625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDC46_RS01635	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDC46_RS01640	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CDC46_RS01640	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CDC46_RS01645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC46_RS01675	COG3511	phospholipase C
CDC46_RS01690	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDC46_RS01695	COG0321	lipoyl(octanoyl) transferase activity
CDC46_RS01705	COG0583	DNA-binding transcription factor activity
CDC46_RS01710	COG2921	Belongs to the UPF0250 family
CDC46_RS01715	COG1686	Belongs to the peptidase S11 family
CDC46_RS01720	COG2945	thiolester hydrolase activity
CDC46_RS01725	COG3411	Ferredoxin
CDC46_RS01730	COG1301	dicarboxylic acid transport
CDC46_RS01740	COG2204	response regulator
CDC46_RS01750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CDC46_RS01795	COG0004	ammonium transporteR
CDC46_RS01805	COG0189	ligase activity
CDC46_RS01815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC46_RS01820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC46_RS01840	COG0793	Belongs to the peptidase S41A family
CDC46_RS01845	COG0588	phosphoglycerate mutase activity
CDC46_RS01855	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDC46_RS01860	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CDC46_RS01865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDC46_RS01875	COG1040	competence protein
CDC46_RS01880	COG2226	methyltransferase
CDC46_RS01895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC46_RS01900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CDC46_RS01930	COG1612	heme a metabolic process
CDC46_RS01935	COG0109	protoheme IX farnesyltransferase activity
CDC46_RS01940	COG1999	signal sequence binding
CDC46_RS01945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC46_RS01950	COG5001	Diguanylate cyclase
CDC46_RS01950	COG3300	MHYT domain
CDC46_RS01960	COG1741	Belongs to the pirin family
CDC46_RS01965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC46_RS01970	COG1116	anion transmembrane transporter activity
CDC46_RS01975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC46_RS01980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC46_RS01990	COG3707	response regulator
CDC46_RS02000	COG0625	glutathione transferase activity
CDC46_RS02015	COG0612	Peptidase, M16
CDC46_RS02020	COG0612	Peptidase, M16
CDC46_RS02025	COG0742	ribosomal rna small subunit methyltransferase
CDC46_RS02030	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDC46_RS02035	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC46_RS02045	COG0193	aminoacyl-tRNA hydrolase activity
CDC46_RS02050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDC46_RS02055	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC46_RS02065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDC46_RS02070	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CDC46_RS02080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDC46_RS02090	COG1194	a g-specific adenine glycosylase
CDC46_RS02100	COG1660	Displays ATPase and GTPase activities
CDC46_RS02110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CDC46_RS02120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDC46_RS02125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC46_RS02130	COG1137	ATPase activity
CDC46_RS02145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDC46_RS02170	COG0693	protein deglycase activity
CDC46_RS02175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDC46_RS02195	COG2814	Major facilitator Superfamily
CDC46_RS02200	COG0629	single-stranded DNA binding
CDC46_RS02225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC46_RS02250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC46_RS02265	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS02280	COG2391	methyltransferase activity
CDC46_RS02295	COG3265	gluconokinase activity
CDC46_RS02300	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS02330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC46_RS02330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC46_RS02335	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDC46_RS02350	COG0700	Nucleoside recognition
CDC46_RS02355	COG1238	metal cluster binding
CDC46_RS02370	COG4178	(ABC) transporter
CDC46_RS02380	COG2226	methyltransferase
CDC46_RS02395	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC46_RS02400	COG0500	methyltransferase
CDC46_RS02420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDC46_RS02430	COG0494	nUDIX hydrolase
CDC46_RS02435	COG3568	Endonuclease Exonuclease Phosphatase
CDC46_RS02440	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC46_RS02455	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS02460	COG1024	Enoyl-CoA hydratase
CDC46_RS02460	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC46_RS02465	COG0183	Belongs to the thiolase family
CDC46_RS02470	COG1024	Enoyl-CoA hydratase
CDC46_RS02480	COG5265	(ABC) transporter
CDC46_RS02490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDC46_RS02500	COG0765	amino acid transport
CDC46_RS02505	COG0765	amino acid transport
CDC46_RS02510	COG1126	abc transporter atp-binding protein
CDC46_RS02515	COG0121	glutamine amidotransferase
CDC46_RS02530	COG0418	dihydroorotase activity
CDC46_RS02550	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDC46_RS02555	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDC46_RS02570	COG0316	Belongs to the HesB IscA family
CDC46_RS02575	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDC46_RS02580	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDC46_RS02585	COG1490	D-aminoacyl-tRNA deacylase activity
CDC46_RS02600	COG2255	four-way junction helicase activity
CDC46_RS02605	COG0632	four-way junction helicase activity
CDC46_RS02615	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDC46_RS02620	COG0138	bifunctional purine biosynthesis protein purh
CDC46_RS02625	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDC46_RS02640	COG4680	protein conserved in bacteria
CDC46_RS02650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC46_RS02655	COG0006	proline dipeptidase activity
CDC46_RS02665	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC46_RS02685	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CDC46_RS02695	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDC46_RS02700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDC46_RS02705	COG0697	spore germination
CDC46_RS02710	COG0346	lactoylglutathione lyase activity
CDC46_RS02720	COG0204	Acyl-transferase
CDC46_RS02725	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CDC46_RS02730	COG0751	glycine-tRNA ligase activity
CDC46_RS02740	COG0752	glycyl-tRNA synthetase alpha subunit
CDC46_RS02745	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDC46_RS02750	COG4535	Mg2 and Co2 transporter CorC
CDC46_RS02755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDC46_RS02760	COG1702	phosphate starvation-inducible protein PhoH
CDC46_RS02765	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC46_RS02775	COG0493	'glutamate synthase
CDC46_RS02775	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC46_RS02820	COG0513	Belongs to the DEAD box helicase family
CDC46_RS02840	COG0745	RESPONSE REGULATOR receiver
CDC46_RS02865	COG0477	Major facilitator Superfamily
CDC46_RS02875	COG0642	Histidine kinase
CDC46_RS02885	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDC46_RS02890	COG2137	regulation of response to DNA damage stimulus
CDC46_RS02900	COG0045	succinate-CoA ligase (ADP-forming) activity
CDC46_RS02905	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CDC46_RS02910	COG0861	Integral membrane protein TerC family
CDC46_RS02915	COG4969	Belongs to the N-Me-Phe pilin family
CDC46_RS02920	COG4969	Belongs to the N-Me-Phe pilin family
CDC46_RS02930	COG0315	cyclic pyranopterin monophosphate synthase activity
CDC46_RS02935	COG4783	chaperone-mediated protein folding
CDC46_RS02945	COG0429	hydrolase of the alpha beta-hydrolase fold
CDC46_RS02955	COG0859	PFAM glycosyl transferase family 9
CDC46_RS02985	COG0126	phosphoglycerate kinase activity
CDC46_RS02990	COG0469	pyruvate kinase activity
CDC46_RS03000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDC46_RS03005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDC46_RS03015	COG0009	L-threonylcarbamoyladenylate synthase
CDC46_RS03030	COG0546	phosphoglycolate phosphatase activity
CDC46_RS03040	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC46_RS03045	COG2027	D-alanyl-D-alanine carboxypeptidase
CDC46_RS03050	COG0738	Major facilitator superfamily
CDC46_RS03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS03125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC46_RS03125	COG3008	intermembrane lipid transfer
CDC46_RS03130	COG2995	paraquat-inducible protein a
CDC46_RS03150	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDC46_RS03155	COG0840	transmembrane signaling receptor activity
CDC46_RS03200	COG0697	spore germination
CDC46_RS03225	COG2974	May be involved in recombination
CDC46_RS03230	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CDC46_RS03235	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC46_RS03250	COG0513	Belongs to the DEAD box helicase family
CDC46_RS03270	COG2207	Transcriptional regulator
CDC46_RS03290	COG4654	Cytochrome c, class I
CDC46_RS03305	COG1064	alcohol dehydrogenase
CDC46_RS03315	COG0583	DNA-binding transcription factor activity
CDC46_RS03325	COG1309	transcriptional regulator
CDC46_RS03345	COG0443	Heat shock 70 kDa protein
CDC46_RS03355	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDC46_RS03360	COG0459	protein refolding
CDC46_RS03365	COG4269	membrane
CDC46_RS03425	COG4964	Belongs to the GSP D family
CDC46_RS03470	COG1704	LemA family
CDC46_RS03480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC46_RS03485	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC46_RS03490	COG1773	rubredoxin
CDC46_RS03510	COG0840	transmembrane signaling receptor activity
CDC46_RS03515	COG0784	Response regulator, receiver
CDC46_RS03515	COG0643	Histidine kinase
CDC46_RS03515	COG2198	Histidine kinase
CDC46_RS03515	COG0784	Response regulator, receiver
CDC46_RS03515	COG2198	Histidine kinase
CDC46_RS03515	COG0643	Histidine kinase
CDC46_RS03530	COG1678	Uncharacterized ACR, COG1678
CDC46_RS03535	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDC46_RS03540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CDC46_RS03545	COG0540	Belongs to the ATCase OTCase family
CDC46_RS03560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDC46_RS03610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC46_RS03615	COG0859	PFAM glycosyl transferase family 9
CDC46_RS03635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDC46_RS03635	COG0425	Belongs to the sulfur carrier protein TusA family
CDC46_RS03640	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC46_RS03665	COG1968	undecaprenyl-diphosphatase activity
CDC46_RS03670	COG1902	pentaerythritol trinitrate reductase activity
CDC46_RS03675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDC46_RS03705	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDC46_RS03715	COG0436	Aminotransferase
CDC46_RS03720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC46_RS03725	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDC46_RS03740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC46_RS03740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC46_RS03805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CDC46_RS03810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC46_RS03815	COG4221	oxidoreductase activity
CDC46_RS03820	COG0824	Thioesterase
CDC46_RS03840	COG0823	Involved in the tonB-independent uptake of proteins
CDC46_RS03855	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDC46_RS03860	COG2391	methyltransferase activity
CDC46_RS03875	COG0745	RESPONSE REGULATOR receiver
CDC46_RS03880	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC46_RS03885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC46_RS03900	COG2175	clavaminate synthase activity
CDC46_RS03910	COG0390	transport system, permease component
CDC46_RS03915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC46_RS03935	COG4575	ribosome binding
CDC46_RS03940	COG0450	alkyl hydroperoxide reductase
CDC46_RS03950	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS03960	COG3483	tryptophan 2,3-dioxygenase activity
CDC46_RS03970	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC46_RS03975	COG1522	sequence-specific DNA binding
CDC46_RS03990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC46_RS04000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC46_RS04005	COG0259	pyridoxamine-phosphate oxidase activity
CDC46_RS04030	COG2982	Protein involved in outer membrane biogenesis
CDC46_RS04035	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDC46_RS04045	COG2703	oxygen carrier activity
CDC46_RS04055	COG3118	belongs to the thioredoxin family
CDC46_RS04060	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS04070	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CDC46_RS04090	COG4681	YaeQ
CDC46_RS04120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC46_RS04145	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC46_RS04165	COG4774	siderophore transport
CDC46_RS04175	COG0330	HflC and HflK could
CDC46_RS04190	COG0477	Major facilitator Superfamily
CDC46_RS04195	COG0235	Class ii aldolase
CDC46_RS04200	COG1942	4-Oxalocrotonate Tautomerase
CDC46_RS04215	COG0425	Belongs to the sulfur carrier protein TusA family
CDC46_RS04230	COG1280	lysine exporter protein (LysE YggA)
CDC46_RS04250	COG4305	rare lipoprotein A
CDC46_RS04265	COG0778	Nitroreductase
CDC46_RS04305	COG0653	protein targeting
CDC46_RS04605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDC46_RS04650	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC46_RS04675	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDC46_RS04685	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC46_RS04690	COG0287	Prephenate dehydrogenase
CDC46_RS04695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDC46_RS04700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CDC46_RS04710	COG0776	regulation of translation
CDC46_RS04720	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CDC46_RS04730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CDC46_RS04735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC46_RS04750	COG2951	lytic endotransglycosylase activity
CDC46_RS04755	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC46_RS04760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDC46_RS04765	COG2011	ABC-type metal ion transport system permease component
CDC46_RS04785	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS04790	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS04825	COG0228	four-way junction DNA binding
CDC46_RS04830	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDC46_RS04835	COG0336	Belongs to the RNA methyltransferase TrmD family
CDC46_RS04840	COG0335	large ribosomal subunit rRNA binding
CDC46_RS04845	COG0494	nUDIX hydrolase
CDC46_RS04850	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC46_RS04860	COG1162	GTPase activity
CDC46_RS04870	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDC46_RS04875	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDC46_RS04880	COG3028	Belongs to the UPF0307 family
CDC46_RS04895	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDC46_RS04905	COG0861	Integral membrane protein TerC family
CDC46_RS04915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC46_RS04920	COG0513	Belongs to the DEAD box helicase family
CDC46_RS04985	COG0582	viral genome integration into host DNA
CDC46_RS05010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS05020	COG0488	(ABC) transporter
CDC46_RS05050	COG1620	l-lactate permease
CDC46_RS05065	COG0625	glutathione transferase activity
CDC46_RS05070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS05080	COG0697	spore germination
CDC46_RS05085	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC46_RS05090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS05095	COG0326	Molecular chaperone. Has ATPase activity
CDC46_RS05165	COG0778	Nitroreductase
CDC46_RS05170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDC46_RS05175	COG2878	Part of a membrane complex involved in electron transport
CDC46_RS05180	COG1309	transcriptional regulator
CDC46_RS05205	COG0556	nucleotide-excision repair
CDC46_RS05215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC46_RS05220	COG1609	Transcriptional regulator
CDC46_RS05225	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDC46_RS05235	COG1879	ABC-type sugar transport system periplasmic component
CDC46_RS05245	COG1104	cysteine desulfurase activity
CDC46_RS05250	COG0822	iron-sulfur transferase activity
CDC46_RS05255	COG0316	Belongs to the HesB IscA family
CDC46_RS05265	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CDC46_RS05270	COG0443	Heat shock 70 kDa protein
CDC46_RS05275	COG0633	Ferredoxin
CDC46_RS05290	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDC46_RS05295	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS05320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC46_RS05340	COG0746	molybdenum cofactor guanylyltransferase activity
CDC46_RS05345	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDC46_RS05350	COG1530	ribonuclease E activity
CDC46_RS05360	COG0546	phosphoglycolate phosphatase activity
CDC46_RS05370	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDC46_RS05370	COG0616	signal peptide processing
CDC46_RS05380	COG0424	maF-like protein
CDC46_RS05385	COG1399	metal-binding, possibly nucleic acid-binding protein
CDC46_RS05390	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDC46_RS05395	COG0416	fatty acid biosynthetic process
CDC46_RS05400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDC46_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS05415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC46_RS05420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC46_RS05445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC46_RS05455	COG0481	GTPase activity
CDC46_RS05460	COG0681	Belongs to the peptidase S26 family
CDC46_RS05470	COG0571	ribonuclease III activity
CDC46_RS05475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDC46_RS05480	COG1381	Involved in DNA repair and RecF pathway recombination
CDC46_RS05485	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDC46_RS05490	COG0736	holo-[acyl-carrier-protein] synthase activity
CDC46_RS05500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDC46_RS05510	COG0322	excinuclease ABC activity
CDC46_RS05540	COG0745	RESPONSE REGULATOR receiver
CDC46_RS05550	COG5002	protein histidine kinase activity
CDC46_RS05560	COG0745	RESPONSE REGULATOR receiver
CDC46_RS05570	COG2186	Transcriptional regulator
CDC46_RS05580	COG2271	Major facilitator Superfamily
CDC46_RS05590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS05600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS05605	COG0625	glutathione transferase activity
CDC46_RS05645	COG2271	Major facilitator Superfamily
CDC46_RS05650	COG0583	DNA-binding transcription factor activity
CDC46_RS05660	COG0436	Aminotransferase
CDC46_RS05690	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC46_RS05690	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC46_RS05730	COG0583	DNA-binding transcription factor activity
CDC46_RS05735	COG2855	membrane
CDC46_RS05760	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC46_RS05765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDC46_RS05780	COG1136	(ABC) transporter
CDC46_RS05785	COG0084	hydrolase, TatD family'
CDC46_RS05795	COG2308	Evidence 4 Homologs of previously reported genes of
CDC46_RS05815	COG2267	carboxylic ester hydrolase activity
CDC46_RS05820	COG0504	CTP synthase activity
CDC46_RS05825	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDC46_RS05835	COG0148	phosphopyruvate hydratase activity
CDC46_RS05840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDC46_RS05850	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDC46_RS05860	COG2833	Protein of unknown function (DUF455)
CDC46_RS05865	COG2267	carboxylic ester hydrolase activity
CDC46_RS05885	COG0492	ferredoxin-NADP+ reductase activity
CDC46_RS05890	COG0613	PHP domain protein
CDC46_RS05895	COG0009	L-threonylcarbamoyladenylate synthase
CDC46_RS05900	COG1994	Peptidase M50
CDC46_RS05905	COG0180	Tryptophanyl-tRNA synthetase
CDC46_RS05915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC46_RS05920	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CDC46_RS05925	COG0321	lipoyl(octanoyl) transferase activity
CDC46_RS05925	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CDC46_RS05935	COG2850	peptidyl-arginine hydroxylation
CDC46_RS05950	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CDC46_RS05955	COG0583	DNA-binding transcription factor activity
CDC46_RS05960	COG2814	Major facilitator Superfamily
CDC46_RS05965	COG0656	L-ascorbic acid biosynthetic process
CDC46_RS05980	COG2258	MOSC domain
CDC46_RS05990	COG1396	sequence-specific DNA binding
CDC46_RS05995	COG0483	inositol monophosphate 1-phosphatase activity
CDC46_RS06005	COG1045	serine acetyltransferase
CDC46_RS06010	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC46_RS06030	COG0215	cysteine-tRNA ligase activity
CDC46_RS06035	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CDC46_RS06040	COG0825	malonyl-CoA metabolic process
CDC46_RS06045	COG0037	tRNA processing
CDC46_RS06050	COG0527	aspartate kinase activity
CDC46_RS06065	COG4166	transmembrane transport
CDC46_RS06070	COG4174	ABC transporter (Permease)
CDC46_RS06075	COG4239	(ABC) transporter, permease
CDC46_RS06080	COG4172	Belongs to the ABC transporter superfamily
CDC46_RS06085	COG0791	NLP P60 protein
CDC46_RS06090	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDC46_RS06095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC46_RS06130	COG0534	Mate efflux family protein
CDC46_RS06140	COG0254	rRNA binding
CDC46_RS06150	COG3228	Belongs to the MtfA family
CDC46_RS06155	COG2197	response regulator
CDC46_RS06160	COG2204	response regulator
CDC46_RS06165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDC46_RS06180	COG1074	ATP-dependent DNA helicase activity
CDC46_RS06190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CDC46_RS06195	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDC46_RS06200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDC46_RS06215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC46_RS06220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC46_RS06230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC46_RS06235	COG1309	transcriptional regulator
CDC46_RS06240	COG1902	pentaerythritol trinitrate reductase activity
CDC46_RS06250	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDC46_RS06255	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC46_RS06275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDC46_RS06285	COG0105	UTP biosynthetic process
CDC46_RS06290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDC46_RS06305	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDC46_RS06310	COG0124	histidyl-tRNA synthetase
CDC46_RS06315	COG2976	Protein conserved in bacteria
CDC46_RS06325	COG1160	GTP binding
CDC46_RS06330	COG1923	regulation of RNA biosynthetic process
CDC46_RS06335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDC46_RS06340	COG0330	HflC and HflK could
CDC46_RS06345	COG0330	HflC and HflK could
CDC46_RS06355	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDC46_RS06360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDC46_RS06365	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CDC46_RS06375	COG0557	exoribonuclease II activity
CDC46_RS06380	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC46_RS06385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CDC46_RS06390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC46_RS06395	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDC46_RS06400	COG1953	Uracil, thiamine, allantoin
CDC46_RS06410	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CDC46_RS06420	COG3718	enzyme involved in inositol metabolism
CDC46_RS06430	COG3962	Belongs to the TPP enzyme family
CDC46_RS06435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC46_RS06445	COG1129	ABC transporter
CDC46_RS06450	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDC46_RS06455	COG1082	Xylose isomerase domain protein TIM barrel
CDC46_RS06465	COG0673	inositol 2-dehydrogenase activity
CDC46_RS06475	COG0673	inositol 2-dehydrogenase activity
CDC46_RS06480	COG1737	Transcriptional regulator
CDC46_RS06485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDC46_RS06485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC46_RS06515	COG1058	Belongs to the CinA family
CDC46_RS06515	COG1546	Belongs to the CinA family
CDC46_RS06525	COG0174	glutamine synthetase
CDC46_RS06540	COG2204	response regulator
CDC46_RS06550	COG2217	Heavy metal translocating P-type atpase
CDC46_RS06555	COG1653	transport
CDC46_RS06560	COG1175	transmembrane transport
CDC46_RS06565	COG0395	ABC-type sugar transport system, permease component
CDC46_RS06570	COG3842	ATPase activity
CDC46_RS06575	COG0584	glycerophosphoryl diester phosphodiesterase
CDC46_RS06580	COG0567	Dehydrogenase, E1 component
CDC46_RS06585	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC46_RS06590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC46_RS06595	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CDC46_RS06605	COG2217	Heavy metal translocating P-type atpase
CDC46_RS06615	COG3278	Belongs to the heme-copper respiratory oxidase family
CDC46_RS06650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC46_RS06660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDC46_RS06665	COG1187	pseudouridine synthase activity
CDC46_RS06670	COG0779	Required for maturation of 30S ribosomal subunits
CDC46_RS06675	COG2251	uridine kinase activity
CDC46_RS06675	COG0195	Participates in both transcription termination and antitermination
CDC46_RS06680	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDC46_RS06685	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDC46_RS06690	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDC46_RS06695	COG2814	Major facilitator Superfamily
CDC46_RS06700	COG1566	PFAM secretion protein HlyD family protein
CDC46_RS06715	COG1217	gtp-binding protein TYPA
CDC46_RS06725	COG1024	Enoyl-CoA hydratase
CDC46_RS06730	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC46_RS06750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC46_RS06765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDC46_RS06780	COG0360	Binds together with S18 to 16S ribosomal RNA
CDC46_RS06790	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDC46_RS06795	COG0359	binds to the 23S rRNA
CDC46_RS06810	COG0306	phosphate transporter
CDC46_RS06815	COG0791	NLP P60 protein
CDC46_RS06825	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDC46_RS06830	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDC46_RS06835	COG0726	polysaccharide deacetylase
CDC46_RS06840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC46_RS06840	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC46_RS06855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC46_RS06860	COG2076	Multidrug Resistance protein
CDC46_RS06865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDC46_RS06875	COG0436	Aminotransferase
CDC46_RS06890	COG1573	uracil-dna glycosylase
CDC46_RS06895	COG0303	'Molybdopterin
CDC46_RS06900	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CDC46_RS06905	COG0314	molybdopterin synthase activity
CDC46_RS06910	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDC46_RS06920	COG0542	response to heat
CDC46_RS06925	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDC46_RS06930	COG0431	NADPH-dependent FMN reductase
CDC46_RS06935	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC46_RS06940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC46_RS06945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC46_RS06950	COG1116	anion transmembrane transporter activity
CDC46_RS06970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDC46_RS06975	COG4208	sulfate ABC transporter
CDC46_RS06985	COG0583	DNA-binding transcription factor activity
CDC46_RS07000	COG3275	phosphorelay sensor kinase activity
CDC46_RS07015	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC46_RS07035	COG2224	Isocitrate lyase
CDC46_RS07045	COG0583	DNA-binding transcription factor activity
CDC46_RS07060	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDC46_RS07070	COG2814	Major facilitator Superfamily
CDC46_RS07080	COG1214	PFAM Peptidase M22, glycoprotease
CDC46_RS07085	COG0456	acetyltransferase
CDC46_RS07090	COG1573	uracil-dna glycosylase
CDC46_RS07095	COG0477	Major facilitator Superfamily
CDC46_RS07100	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDC46_RS07110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC46_RS07115	COG1683	Conserved Protein
CDC46_RS07120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC46_RS07125	COG0488	(ABC) transporter
CDC46_RS07135	COG1446	asparaginase
CDC46_RS07140	COG4172	Belongs to the ABC transporter superfamily
CDC46_RS07145	COG0747	negative chemotaxis
CDC46_RS07155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC46_RS07180	COG0302	gtp cyclohydrolase
CDC46_RS07185	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC46_RS07195	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC46_RS07200	COG1393	Belongs to the ArsC family
CDC46_RS07210	COG2171	N-acyltransferase activity
CDC46_RS07225	COG0596	Alpha beta hydrolase
CDC46_RS07240	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDC46_RS07245	COG0242	peptide deformylase activity
CDC46_RS07255	COG1187	pseudouridine synthase activity
CDC46_RS07260	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDC46_RS07265	COG0024	Methionine aminopeptidase
CDC46_RS07270	COG0052	Belongs to the universal ribosomal protein uS2 family
CDC46_RS07275	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDC46_RS07280	COG0528	UMP kinase activity
CDC46_RS07285	COG0233	cytoplasmic translational termination
CDC46_RS07290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDC46_RS07295	COG0575	Belongs to the CDS family
CDC46_RS07300	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDC46_RS07305	COG0750	zinc metalloprotease
CDC46_RS07320	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC46_RS07325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC46_RS07330	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC46_RS07335	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC46_RS07340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDC46_RS07345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC46_RS07350	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CDC46_RS07365	COG0330	HflC and HflK could
CDC46_RS07370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDC46_RS07375	COG2867	negative regulation of translational initiation
CDC46_RS07380	COG2914	Belongs to the UPF0125 (RnfH) family
CDC46_RS07390	COG0697	spore germination
CDC46_RS07405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC46_RS07405	COG0519	Catalyzes the synthesis of GMP from XMP
CDC46_RS07465	COG0583	DNA-binding transcription factor activity
CDC46_RS07470	COG3485	protocatechuate 3,4-dioxygenase
CDC46_RS07475	COG3485	protocatechuate 3,4-dioxygenase
CDC46_RS07495	COG3550	peptidyl-serine autophosphorylation
CDC46_RS07515	COG0602	queuosine metabolic process
CDC46_RS07520	COG0720	synthase
CDC46_RS07530	COG1619	proteins homologs of microcin C7 resistance protein MccF
CDC46_RS07535	COG0488	(ABC) transporter
CDC46_RS07560	COG3387	PFAM Glycoside hydrolase 15-related
CDC46_RS07570	COG0840	transmembrane signaling receptor activity
CDC46_RS07580	COG1022	Amp-dependent synthetase and ligase
CDC46_RS07580	COG3320	Male sterility
CDC46_RS07585	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDC46_RS07620	COG3045	CreA protein
CDC46_RS07625	COG0583	DNA-binding transcription factor activity
CDC46_RS07655	COG0156	8-amino-7-oxononanoate synthase activity
CDC46_RS07660	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDC46_RS07725	COG0582	viral genome integration into host DNA
CDC46_RS07755	COG0656	L-ascorbic acid biosynthetic process
CDC46_RS07760	COG2304	oxidoreductase activity
CDC46_RS07815	COG0328	RNA-DNA hybrid ribonuclease activity
CDC46_RS07820	COG2226	methyltransferase
CDC46_RS07825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC46_RS07830	COG1388	LysM domain
CDC46_RS07830	COG0741	lytic transglycosylase activity
CDC46_RS07835	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC46_RS07840	COG0505	Belongs to the CarA family
CDC46_RS07850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDC46_RS07855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC46_RS07865	COG1534	Rna-binding protein
CDC46_RS07870	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDC46_RS07875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC46_RS07880	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDC46_RS07885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC46_RS07890	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC46_RS07895	COG0573	inorganic phosphate transmembrane transporter activity
CDC46_RS07900	COG0581	inorganic phosphate transmembrane transporter activity
CDC46_RS07905	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC46_RS07915	COG0745	RESPONSE REGULATOR receiver
CDC46_RS07925	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CDC46_RS07930	COG0248	Ppx GppA phosphatase
CDC46_RS07955	COG0730	response to heat
CDC46_RS07965	COG0640	Transcriptional regulator
CDC46_RS07975	COG5001	Diguanylate cyclase
CDC46_RS07975	COG3300	MHYT domain
CDC46_RS07985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC46_RS08015	COG2963	transposase activity
CDC46_RS08075	COG1295	ribonuclease BN
CDC46_RS08100	COG0477	Major facilitator Superfamily
CDC46_RS08105	COG0545	Peptidyl-prolyl cis-trans isomerase
CDC46_RS08110	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDC46_RS08120	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS08125	COG4566	intracellular signal transduction
CDC46_RS08140	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS08150	COG0251	oxidation-reduction process
CDC46_RS08155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC46_RS08165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDC46_RS08170	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDC46_RS08175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDC46_RS08180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDC46_RS08185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDC46_RS08190	COG0072	phenylalanine-tRNA ligase activity
CDC46_RS08190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC46_RS08195	COG0776	regulation of translation
CDC46_RS08220	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDC46_RS08225	COG0531	amino acid
CDC46_RS08245	COG1846	Transcriptional regulator
CDC46_RS08255	COG0402	S-adenosylhomocysteine deaminase activity
CDC46_RS08260	COG0339	signal peptide processing
CDC46_RS08265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDC46_RS08270	COG4566	intracellular signal transduction
CDC46_RS08280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CDC46_RS08295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC46_RS08310	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC46_RS08335	COG1414	Transcriptional regulator
CDC46_RS08360	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CDC46_RS08365	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDC46_RS08385	COG0167	dihydroorotate dehydrogenase activity
CDC46_RS08395	COG3158	transport of potassium into the cell
CDC46_RS08405	COG2183	response to ionizing radiation
CDC46_RS08420	COG1199	ATP-dependent helicase activity
CDC46_RS08430	COG0564	pseudouridine synthase activity
CDC46_RS08445	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDC46_RS08450	COG0183	Belongs to the thiolase family
CDC46_RS08455	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS08465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC46_RS08470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC46_RS08475	COG0183	Belongs to the thiolase family
CDC46_RS08485	COG0626	cystathionine gamma-synthase activity
CDC46_RS08490	COG0560	Phosphoserine phosphatase
CDC46_RS08505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDC46_RS08510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDC46_RS08515	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC46_RS08520	COG0450	alkyl hydroperoxide reductase
CDC46_RS08700	COG4626	Terminase
CDC46_RS08700	COG1802	Transcriptional regulator
CDC46_RS08755	COG1196	nuclear chromosome segregation
CDC46_RS08835	COG3039	Transposase
CDC46_RS08845	COG1652	LysM domain
CDC46_RS08855	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC46_RS08855	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS08860	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDC46_RS08865	COG0740	serine-type endopeptidase activity
CDC46_RS08870	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDC46_RS08875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDC46_RS08880	COG0776	regulation of translation
CDC46_RS08895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC46_RS08900	COG0681	Belongs to the peptidase S26 family
CDC46_RS08910	COG4181	ATPase activity
CDC46_RS08915	COG0166	Belongs to the GPI family
CDC46_RS08920	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDC46_RS08930	COG0047	phosphoribosylformylglycinamidine synthase activity
CDC46_RS08930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDC46_RS08950	COG0535	radical SAM domain protein
CDC46_RS08955	COG0583	DNA-binding transcription factor activity
CDC46_RS08960	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS08965	COG1177	transmembrane transport
CDC46_RS08970	COG1176	ABC-type spermidine putrescine transport system, permease component I
CDC46_RS08980	COG3842	ATPase activity
CDC46_RS08985	COG0642	Histidine kinase
CDC46_RS08995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS09000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CDC46_RS09025	COG1126	abc transporter atp-binding protein
CDC46_RS09030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC46_RS09040	COG2917	probably involved in intracellular septation
CDC46_RS09045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC46_RS09050	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDC46_RS09055	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS09095	COG0833	amino acid
CDC46_RS09100	COG0833	amino acid
CDC46_RS09105	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC46_RS09105	COG1024	Enoyl-CoA hydratase
CDC46_RS09110	COG1335	isochorismatase
CDC46_RS09115	COG0183	Belongs to the thiolase family
CDC46_RS09120	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS09125	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS09140	COG2130	NADP-dependent
CDC46_RS09160	COG0596	Alpha beta hydrolase
CDC46_RS09200	COG2831	hemolysin activation secretion protein
CDC46_RS09220	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDC46_RS09225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDC46_RS09230	COG0470	DNA polymerase III
CDC46_RS09240	COG0084	hydrolase, TatD family'
CDC46_RS09250	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC46_RS09255	COG1609	Transcriptional regulator
CDC46_RS09260	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC46_RS09270	COG4208	sulfate ABC transporter
CDC46_RS09275	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC46_RS09280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC46_RS09285	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDC46_RS09320	COG0038	chloride channel
CDC46_RS09325	COG2226	methyltransferase
CDC46_RS09340	COG4771	TonB-dependent receptor
CDC46_RS09345	COG1132	(ABC) transporter
CDC46_RS09345	COG2375	cellular response to nickel ion
CDC46_RS09360	COG2226	methyltransferase
CDC46_RS09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC46_RS09360	COG3433	isochorismatase activity
CDC46_RS09375	COG2201	protein-glutamate methylesterase activity
CDC46_RS09380	COG0456	acetyltransferase
CDC46_RS09425	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDC46_RS09475	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC46_RS09490	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS09505	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CDC46_RS09535	COG2801	Transposase and inactivated derivatives
CDC46_RS09585	COG2814	Major facilitator Superfamily
CDC46_RS09610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS09620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC46_RS09680	COG0582	viral genome integration into host DNA
CDC46_RS09690	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDC46_RS09735	COG2072	flavoprotein involved in K transport
CDC46_RS09740	COG0601	transmembrane transport
CDC46_RS09745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC46_RS09755	COG4608	Belongs to the ABC transporter superfamily
CDC46_RS09760	COG0747	negative chemotaxis
CDC46_RS09790	COG3706	GGDEF domain
CDC46_RS09795	COG0840	transmembrane signaling receptor activity
CDC46_RS09800	COG2197	response regulator
CDC46_RS10010	COG4695	Portal protein
CDC46_RS10045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDC46_RS10050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC46_RS10055	COG0697	spore germination
CDC46_RS10070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDC46_RS10075	COG1301	dicarboxylic acid transport
CDC46_RS10120	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CDC46_RS10150	COG1131	(ABC) transporter
CDC46_RS10155	COG0842	Transport permease protein
CDC46_RS10175	COG0285	dihydrofolate synthase activity
CDC46_RS10180	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDC46_RS10185	COG0159	tryptophan synthase activity
CDC46_RS10195	COG0133	tryptophan synthase activity
CDC46_RS10205	COG0101	tRNA pseudouridine synthase activity
CDC46_RS10220	COG0473	3-isopropylmalate dehydrogenase activity
CDC46_RS10225	COG0066	3-isopropylmalate dehydratase activity
CDC46_RS10230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDC46_RS10235	COG0372	Belongs to the citrate synthase family
CDC46_RS10240	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDC46_RS10245	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDC46_RS10250	COG1053	succinate dehydrogenase
CDC46_RS10255	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CDC46_RS10265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC46_RS10270	COG0039	L-malate dehydrogenase activity
CDC46_RS10295	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CDC46_RS10310	COG0747	negative chemotaxis
CDC46_RS10320	COG2866	Carboxypeptidase
CDC46_RS10325	COG3022	response to hydroperoxide
CDC46_RS10335	COG0436	Aminotransferase
CDC46_RS10340	COG0625	glutathione transferase activity
CDC46_RS10345	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC46_RS10350	COG1024	Enoyl-CoA hydratase
CDC46_RS10380	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS10385	COG0625	glutathione transferase activity
CDC46_RS10415	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDC46_RS10420	COG0830	nickel cation binding
CDC46_RS10425	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CDC46_RS10435	COG0832	Belongs to the urease beta subunit family
CDC46_RS10445	COG0831	urea catabolic process
CDC46_RS10450	COG0829	nickel cation binding
CDC46_RS10485	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS10485	COG2030	dehydratase
CDC46_RS10490	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS10495	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS10515	COG1007	ATP synthesis coupled electron transport
CDC46_RS10530	COG0713	ATP synthesis coupled electron transport
CDC46_RS10540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC46_RS10545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDC46_RS10550	COG1034	ATP synthesis coupled electron transport
CDC46_RS10565	COG0649	NAD binding
CDC46_RS10570	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC46_RS10575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC46_RS10580	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC46_RS10590	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDC46_RS10595	COG0149	triose-phosphate isomerase activity
CDC46_RS10600	COG1063	alcohol dehydrogenase
CDC46_RS10610	COG1185	polyribonucleotide nucleotidyltransferase activity
CDC46_RS10615	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDC46_RS10620	COG0683	leucine binding
CDC46_RS10630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC46_RS10635	COG1183	phosphatidylcholine synthase activity
CDC46_RS10640	COG0688	phosphatidylethanolamine metabolic process
CDC46_RS10645	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDC46_RS10655	COG0028	Belongs to the TPP enzyme family
CDC46_RS10690	COG0438	transferase activity, transferring glycosyl groups
CDC46_RS10700	COG1309	transcriptional regulator
CDC46_RS10725	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDC46_RS10750	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CDC46_RS10760	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDC46_RS10765	COG0402	S-adenosylhomocysteine deaminase activity
CDC46_RS10770	COG2119	membrane
CDC46_RS10790	COG2186	Transcriptional regulator
CDC46_RS10800	COG0765	amino acid transport
CDC46_RS10805	COG0765	amino acid transport
CDC46_RS10810	COG1126	abc transporter atp-binding protein
CDC46_RS10820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS10835	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC46_RS10840	COG2271	Major facilitator Superfamily
CDC46_RS10845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS10860	COG2351	hydroxyisourate hydrolase activity
CDC46_RS10870	COG2233	PERMEase
CDC46_RS10885	COG3648	Uricase
CDC46_RS10885	COG3195	allantoin biosynthetic process
CDC46_RS10895	COG0281	malic enzyme
CDC46_RS10895	COG0280	phosphate acetyltransferase
CDC46_RS10905	COG0308	aminopeptidase N
CDC46_RS10910	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDC46_RS10920	COG2390	Transcriptional regulator
CDC46_RS10925	COG1070	Carbohydrate kinase
CDC46_RS10930	COG0246	Mannitol dehydrogenase
CDC46_RS10955	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS10960	COG0166	Belongs to the GPI family
CDC46_RS10960	COG0166	Belongs to the GPI family
CDC46_RS10965	COG1733	regulation of RNA biosynthetic process
CDC46_RS10975	COG3842	ATPase activity
CDC46_RS10980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC46_RS11005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC46_RS11015	COG1652	LysM domain
CDC46_RS11045	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC46_RS11050	COG1758	RNA polymerase activity
CDC46_RS11055	COG0194	GDP metabolic process
CDC46_RS11060	COG1561	YicC-like family, N-terminal region
CDC46_RS11065	COG4991	sh3 domain protein
CDC46_RS11065	COG3064	Membrane
CDC46_RS11065	COG0515	serine threonine protein kinase
CDC46_RS11075	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDC46_RS11080	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDC46_RS11085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC46_RS11095	COG1234	tRNA 3'-trailer cleavage
CDC46_RS11110	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC46_RS11115	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CDC46_RS11130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC46_RS11135	COG1984	allophanate hydrolase subunit 2
CDC46_RS11140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC46_RS11145	COG2814	Major facilitator Superfamily
CDC46_RS11150	COG3845	ABC transporter
CDC46_RS11155	COG4603	Belongs to the binding-protein-dependent transport system permease family
CDC46_RS11210	COG1803	Methylglyoxal synthase
CDC46_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS11225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CDC46_RS11230	COG0433	COG0433 Predicted ATPase
CDC46_RS11235	COG0217	transcriptional regulatory protein
CDC46_RS11240	COG0151	Belongs to the GarS family
CDC46_RS11245	COG0408	coproporphyrinogen oxidase activity
CDC46_RS11255	COG0799	negative regulation of ribosome biogenesis
CDC46_RS11260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDC46_RS11265	COG1530	ribonuclease E activity
CDC46_RS11280	COG1132	(ABC) transporter
CDC46_RS11310	COG1054	Belongs to the UPF0176 family
CDC46_RS11320	COG1741	Belongs to the pirin family
CDC46_RS11325	COG0583	DNA-binding transcription factor activity
CDC46_RS11330	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC46_RS11335	COG0513	Belongs to the DEAD box helicase family
CDC46_RS11340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC46_RS11340	COG0426	domain, Protein
CDC46_RS11350	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDC46_RS11370	COG1610	YqeY-like protein
CDC46_RS11375	COG2081	HI0933 family
CDC46_RS11380	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDC46_RS11385	COG1469	GTP cyclohydrolase I activity
CDC46_RS11390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDC46_RS11395	COG0142	geranyltranstransferase activity
CDC46_RS11400	COG1722	exodeoxyribonuclease VII activity
CDC46_RS11425	COG0412	Dienelactone hydrolase
CDC46_RS11430	COG1252	NADH dehydrogenase
CDC46_RS11435	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC46_RS11435	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC46_RS11440	COG1611	Belongs to the LOG family
CDC46_RS11450	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDC46_RS11460	COG0210	DNA helicase
CDC46_RS11465	COG0525	valine-tRNA ligase activity
CDC46_RS11480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC46_RS11490	COG2342	PFAM TM1410 hypothetical-related protein
CDC46_RS11505	COG0683	leucine binding
CDC46_RS11515	COG0411	ABC transporter
CDC46_RS11530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC46_RS11535	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC46_RS11545	COG0183	Belongs to the thiolase family
CDC46_RS11550	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDC46_RS11560	COG1414	Transcriptional regulator
CDC46_RS11570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS11580	COG0765	amino acid transport
CDC46_RS11595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS11660	COG1253	flavin adenine dinucleotide binding
CDC46_RS11700	COG3713	MltA-interacting MipA family protein
CDC46_RS11715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC46_RS11785	COG2165	general secretion pathway protein
CDC46_RS11840	COG2197	response regulator
CDC46_RS11855	COG2814	Major facilitator Superfamily
CDC46_RS11865	COG1522	sequence-specific DNA binding
CDC46_RS11875	COG1522	sequence-specific DNA binding
CDC46_RS11880	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS11900	COG1846	Transcriptional regulator
CDC46_RS11915	COG0583	DNA-binding transcription factor activity
CDC46_RS11925	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDC46_RS11965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDC46_RS11970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDC46_RS11980	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDC46_RS11985	COG1674	ftsk spoiiie
CDC46_RS12000	COG2860	membrane
CDC46_RS12030	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDC46_RS12045	COG2271	Major facilitator Superfamily
CDC46_RS12070	COG0181	hydroxymethylbilane synthase activity
CDC46_RS12075	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDC46_RS12100	COG0165	Argininosuccinate lyase
CDC46_RS12115	COG0717	Belongs to the dCTP deaminase family
CDC46_RS12120	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC46_RS12125	COG2032	superoxide dismutase activity
CDC46_RS12145	COG0437	4 iron, 4 sulfur cluster binding
CDC46_RS12150	COG0243	molybdopterin cofactor binding
CDC46_RS12150	COG3383	formate dehydrogenase (NAD+) activity
CDC46_RS12180	COG0489	protein tyrosine kinase activity
CDC46_RS12185	COG2885	chlorophyll binding
CDC46_RS12185	COG3047	cAMP biosynthetic process
CDC46_RS12190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC46_RS12190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC46_RS12200	COG2911	Protein conserved in bacteria
CDC46_RS12215	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDC46_RS12220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDC46_RS12235	COG1492	cobalamin metabolic process
CDC46_RS12245	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC46_RS12255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDC46_RS12265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CDC46_RS12270	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDC46_RS12280	COG1120	ATPase activity
CDC46_RS12290	COG4206	TonB-dependent receptor
CDC46_RS12330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDC46_RS12335	COG0583	DNA-binding transcription factor activity
CDC46_RS12340	COG0129	dihydroxy-acid dehydratase activity
CDC46_RS12355	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDC46_RS12380	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC46_RS12380	COG1648	precorrin-2 dehydrogenase activity
CDC46_RS12385	COG2895	sulfate adenylyltransferase (ATP) activity
CDC46_RS12395	COG0175	sulfate reduction
CDC46_RS12405	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC46_RS12410	COG0730	response to heat
CDC46_RS12415	COG0583	DNA-binding transcription factor activity
CDC46_RS12425	COG2084	Dehydrogenase
CDC46_RS12460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC46_RS12495	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDC46_RS12500	COG1047	Peptidyl-prolyl cis-trans
CDC46_RS12505	COG2003	Belongs to the UPF0758 family
CDC46_RS12510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDC46_RS12515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDC46_RS12520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC46_RS12530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDC46_RS12540	COG1511	domain protein
CDC46_RS12540	COG3264	Mechanosensitive ion channel
CDC46_RS12550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC46_RS12550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC46_RS12555	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDC46_RS12560	COG2197	response regulator
CDC46_RS12565	COG5002	protein histidine kinase activity
CDC46_RS12565	COG0784	Response regulator, receiver
CDC46_RS12570	COG0196	riboflavin kinase activity
CDC46_RS12575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDC46_RS12580	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDC46_RS12590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDC46_RS12595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC46_RS12600	COG0756	dUTP diphosphatase activity
CDC46_RS12605	COG0542	response to heat
CDC46_RS12610	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDC46_RS12615	COG1278	Cold shock
CDC46_RS12725	COG0582	viral genome integration into host DNA
CDC46_RS12745	COG1858	cytochrome C peroxidase
CDC46_RS12765	COG0583	DNA-binding transcription factor activity
CDC46_RS12775	COG0477	Major facilitator Superfamily
CDC46_RS12780	COG2259	Doxx family
CDC46_RS12795	COG2321	neutral zinc metallopeptidase
CDC46_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS12835	COG1473	amidohydrolase
CDC46_RS12870	COG2610	gluconate transmembrane transporter activity
CDC46_RS12915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDC46_RS12920	COG1570	exodeoxyribonuclease VII activity
CDC46_RS12925	COG0811	peptide transport
CDC46_RS12930	COG0848	biopolymer transport protein
CDC46_RS12935	COG1663	tetraacyldisaccharide 4'-kinase activity
CDC46_RS12940	COG2835	tetraacyldisaccharide 4'-kinase activity
CDC46_RS12945	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CDC46_RS12950	COG0563	adenylate kinase activity
CDC46_RS12970	COG0583	DNA-binding transcription factor activity
CDC46_RS12980	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDC46_RS12985	COG0802	atpase or kinase
CDC46_RS12990	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDC46_RS13005	COG4974	Belongs to the 'phage' integrase family
CDC46_RS13015	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDC46_RS13020	COG2366	antibiotic biosynthetic process
CDC46_RS13030	COG1666	GTP binding
CDC46_RS13035	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDC46_RS13045	COG3123	guanosine phosphorylase activity
CDC46_RS13050	COG0137	argininosuccinate synthase activity
CDC46_RS13055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDC46_RS13065	COG0268	Binds directly to 16S ribosomal RNA
CDC46_RS13070	COG0728	peptidoglycan biosynthetic process
CDC46_RS13080	COG0586	Pfam SNARE associated Golgi protein
CDC46_RS13095	COG3008	intermembrane lipid transfer
CDC46_RS13100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDC46_RS13105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC46_RS13115	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC46_RS13115	COG2169	Transcriptional regulator
CDC46_RS13135	COG2169	Transcriptional regulator
CDC46_RS13135	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC46_RS13190	COG3451	type IV secretory pathway VirB4
CDC46_RS13200	COG3838	Conjugal transfer protein Trbc
CDC46_RS13205	COG4962	Type ii secretion system protein e
CDC46_RS13225	COG0583	DNA-binding transcription factor activity
CDC46_RS13240	COG2207	Transcriptional regulator
CDC46_RS13245	COG2315	Protein conserved in bacteria
CDC46_RS13250	COG2272	Belongs to the type-B carboxylesterase lipase family
CDC46_RS13255	COG0625	glutathione transferase activity
CDC46_RS13265	COG1335	isochorismatase
CDC46_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS13275	COG2207	Transcriptional regulator
CDC46_RS13280	COG1201	RNA secondary structure unwinding
CDC46_RS13300	COG4959	Type IV secretory pathway protease TraF
CDC46_RS13315	COG1192	Involved in chromosome partitioning
CDC46_RS13360	COG5489	Protein of unknown function (DUF736)
CDC46_RS13405	COG2003	Belongs to the UPF0758 family
CDC46_RS13410	COG4804	nuclease activity
CDC46_RS13420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDC46_RS13425	COG0628	permease
CDC46_RS13430	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC46_RS13440	COG0617	tRNA 3'-terminal CCA addition
CDC46_RS13445	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDC46_RS13455	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDC46_RS13460	COG4662	Binding-protein-dependent transport system inner membrane component
CDC46_RS13465	COG3842	ATPase activity
CDC46_RS13470	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC46_RS13470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDC46_RS13475	COG0484	heat shock protein binding
CDC46_RS13480	COG0443	Heat shock 70 kDa protein
CDC46_RS13485	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC46_RS13495	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDC46_RS13515	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC46_RS13520	COG1228	amidohydrolase
CDC46_RS13525	COG0010	Belongs to the arginase family
CDC46_RS13530	COG2986	histidine ammonia-lyase
CDC46_RS13535	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CDC46_RS13545	COG1420	regulation of RNA biosynthetic process
CDC46_RS13550	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDC46_RS13555	COG0497	DNA recombination
CDC46_RS13565	COG1404	Belongs to the peptidase S8 family
CDC46_RS13580	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDC46_RS13590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDC46_RS13595	COG0312	modulator of DNA gyrase
CDC46_RS13600	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC46_RS13610	COG0668	transmembrane transport
CDC46_RS13615	COG2096	Adenosyltransferase
CDC46_RS13620	COG0277	FAD linked oxidase domain protein
CDC46_RS13625	COG0583	DNA-binding transcription factor activity
CDC46_RS13630	COG0277	FAD linked oxidase domain protein
CDC46_RS13635	COG0277	FAD linked oxidase domain protein
CDC46_RS13640	COG0247	lactate metabolic process
CDC46_RS13645	COG1380	Effector of murein hydrolase LrgA
CDC46_RS13650	COG1346	cytolysis
CDC46_RS13670	COG0386	Belongs to the glutathione peroxidase family
CDC46_RS13730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC46_RS13735	COG0783	Belongs to the Dps family
CDC46_RS13825	COG1278	Cold shock
CDC46_RS13875	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDC46_RS13880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDC46_RS13885	COG0343	queuine tRNA-ribosyltransferase activity
CDC46_RS13890	COG1862	Preprotein translocase
CDC46_RS13895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC46_RS13900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC46_RS13905	COG2353	YceI-like domain
CDC46_RS13910	COG2353	YceI-like domain
CDC46_RS13915	COG3038	cytochrome b561
CDC46_RS13925	COG0625	glutathione transferase activity
CDC46_RS13930	COG0069	glutamate synthase activity
CDC46_RS13935	COG0482	sulfurtransferase activity
CDC46_RS13975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CDC46_RS14000	COG4191	Histidine kinase
CDC46_RS14005	COG4191	Histidine kinase
CDC46_RS14010	COG2204	response regulator
CDC46_RS14020	COG1981	membrane
CDC46_RS14025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDC46_RS14030	COG1466	dna polymerase III delta subunit
CDC46_RS14040	COG0495	leucyl-tRNA aminoacylation
CDC46_RS14045	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDC46_RS14050	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDC46_RS14055	COG0735	belongs to the Fur family
CDC46_RS14060	COG0583	DNA-binding transcription factor activity
CDC46_RS14065	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDC46_RS14070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDC46_RS14075	COG4948	Mandelate Racemase Muconate Lactonizing
CDC46_RS14080	COG0800	Aldolase
CDC46_RS14085	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS14105	COG1129	ABC transporter
CDC46_RS14120	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS14125	COG0583	DNA-binding transcription factor activity
CDC46_RS14135	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDC46_RS14155	COG0280	phosphate acetyltransferase
CDC46_RS14155	COG0281	malic enzyme
CDC46_RS14165	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDC46_RS14170	COG1546	Belongs to the CinA family
CDC46_RS14170	COG1058	Belongs to the CinA family
CDC46_RS14180	COG0284	orotidine-5'-phosphate decarboxylase activity
CDC46_RS14195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDC46_RS14200	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC46_RS14210	COG0557	exoribonuclease II activity
CDC46_RS14215	COG3161	chorismate lyase activity
CDC46_RS14220	COG3150	esterase
CDC46_RS14225	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC46_RS14235	COG3118	belongs to the thioredoxin family
CDC46_RS14240	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC46_RS14245	COG0511	ligase activity, forming carbon-carbon bonds
CDC46_RS14255	COG2264	protein methyltransferase activity
CDC46_RS14265	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CDC46_RS14270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC46_RS14315	COG0840	transmembrane signaling receptor activity
CDC46_RS14325	COG1522	sequence-specific DNA binding
CDC46_RS14350	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDC46_RS14370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC46_RS14375	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDC46_RS14380	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CDC46_RS14385	COG2095	MarC family integral membrane protein
CDC46_RS14395	COG0741	lytic transglycosylase activity
CDC46_RS14400	COG0442	prolyl-tRNA aminoacylation
CDC46_RS14405	COG0494	nUDIX hydrolase
CDC46_RS14415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDC46_RS14420	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDC46_RS14425	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDC46_RS14430	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDC46_RS14435	COG0142	geranyltranstransferase activity
CDC46_RS14445	COG4536	flavin adenine dinucleotide binding
CDC46_RS14455	COG1459	type II secretion system
CDC46_RS14465	COG0237	dephospho-CoA kinase activity
CDC46_RS14470	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CDC46_RS14475	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDC46_RS14480	COG0494	nUDIX hydrolase
CDC46_RS14490	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDC46_RS14495	COG0653	protein targeting
CDC46_RS14500	COG0739	heme binding
CDC46_RS14510	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDC46_RS14515	COG0678	peroxiredoxin activity
CDC46_RS14530	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDC46_RS14535	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC46_RS14540	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC46_RS14545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDC46_RS14555	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDC46_RS14560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC46_RS14565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDC46_RS14570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDC46_RS14580	COG3116	cell division
CDC46_RS14585	COG0275	rRNA processing
CDC46_RS14590	COG2001	Belongs to the MraZ family
CDC46_RS14595	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CDC46_RS14600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS14605	COG0477	Major facilitator Superfamily
CDC46_RS14610	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS14620	COG0243	molybdopterin cofactor binding
CDC46_RS14625	COG1609	Transcriptional regulator
CDC46_RS14630	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC46_RS14630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC46_RS14635	COG1105	Belongs to the carbohydrate kinase PfkB family
CDC46_RS14640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC46_RS14640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC46_RS14650	COG4608	Belongs to the ABC transporter superfamily
CDC46_RS14660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC46_RS14665	COG0601	transmembrane transport
CDC46_RS14670	COG0747	negative chemotaxis
CDC46_RS14675	COG1473	amidohydrolase
CDC46_RS14705	COG1024	Enoyl-CoA hydratase
CDC46_RS14710	COG1024	Enoyl-CoA hydratase
CDC46_RS14715	COG2050	protein possibly involved in aromatic compounds catabolism
CDC46_RS14735	COG2967	ApaG domain
CDC46_RS14740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDC46_RS14745	COG0546	phosphoglycolate phosphatase activity
CDC46_RS14755	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC46_RS14765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC46_RS14770	COG0134	indole-3-glycerol-phosphate synthase activity
CDC46_RS14775	COG3025	triphosphatase activity
CDC46_RS14780	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDC46_RS14795	COG1289	transmembrane transporter activity
CDC46_RS14805	COG0604	alcohol dehydrogenase
CDC46_RS14845	COG0012	GTP binding
CDC46_RS14855	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDC46_RS14860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDC46_RS14870	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC46_RS14875	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDC46_RS14890	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC46_RS14895	COG3416	Protein conserved in bacteria
CDC46_RS14895	COG2943	transferase activity, transferring hexosyl groups
CDC46_RS14915	COG0488	(ABC) transporter
CDC46_RS14920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CDC46_RS14935	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC46_RS14945	COG3712	iron ion homeostasis
CDC46_RS14950	COG4774	siderophore transport
CDC46_RS14955	COG0405	Gamma-glutamyltransferase
CDC46_RS14980	COG2969	positive regulation of protein catabolic process
CDC46_RS14985	COG0625	glutathione transferase activity
CDC46_RS14990	COG2857	Cytochrome c1
CDC46_RS14995	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDC46_RS15000	COG0723	plastoquinol--plastocyanin reductase activity
CDC46_RS15005	COG1970	mechanosensitive ion channel activity
CDC46_RS15010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDC46_RS15015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC46_RS15020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS15035	COG0642	Histidine kinase
CDC46_RS15050	COG3842	ATPase activity
CDC46_RS15055	COG0805	protein transport
CDC46_RS15060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC46_RS15065	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC46_RS15075	COG0140	phosphoribosyl-ATP diphosphatase activity
CDC46_RS15080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDC46_RS15085	COG0107	imidazoleglycerol-phosphate synthase activity
CDC46_RS15090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDC46_RS15095	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDC46_RS15100	COG2095	MarC family integral membrane protein
CDC46_RS15105	COG0131	Imidazoleglycerol-phosphate dehydratase
CDC46_RS15110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC46_RS15115	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDC46_RS15120	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDC46_RS15125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDC46_RS15135	COG0842	Transport permease protein
CDC46_RS15140	COG1131	(ABC) transporter
CDC46_RS15160	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC46_RS15165	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC46_RS15170	COG1127	ABC transporter
CDC46_RS15195	COG3047	cAMP biosynthetic process
CDC46_RS15200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CDC46_RS15205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDC46_RS15210	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDC46_RS15245	COG1965	Belongs to the frataxin family
CDC46_RS15260	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CDC46_RS15265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC46_RS15285	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC46_RS15290	COG1333	cytochrome c biogenesis protein
CDC46_RS15300	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CDC46_RS15310	COG4232	protein-disulfide reductase activity
CDC46_RS15320	COG0203	ribosomal protein L17
CDC46_RS15325	COG0202	RNA polymerase activity
CDC46_RS15330	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDC46_RS15335	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDC46_RS15340	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDC46_RS15345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDC46_RS15355	COG0201	protein transport
CDC46_RS15360	COG0200	Binds to the 23S rRNA
CDC46_RS15365	COG1841	ribosomal large subunit assembly
CDC46_RS15370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDC46_RS15375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDC46_RS15380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDC46_RS15385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDC46_RS15390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDC46_RS15395	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDC46_RS15400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDC46_RS15405	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDC46_RS15410	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDC46_RS15415	COG0255	Belongs to the universal ribosomal protein uL29 family
CDC46_RS15420	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDC46_RS15425	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDC46_RS15430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDC46_RS15435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDC46_RS15440	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDC46_RS15445	COG0089	rRNA binding
CDC46_RS15450	COG0088	Forms part of the polypeptide exit tunnel
CDC46_RS15455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDC46_RS15460	COG0051	transcription antitermination factor activity, RNA binding
CDC46_RS15465	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC46_RS15475	COG0049	tRNA binding
CDC46_RS15480	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDC46_RS15485	COG0514	ATP-dependent DNA helicase (RecQ)
CDC46_RS15495	COG4676	Protein conserved in bacteria
CDC46_RS15500	COG4676	Protein conserved in bacteria
CDC46_RS15505	COG5445	Predicted secreted protein (DUF2300)
CDC46_RS15510	COG2373	Large extracellular alpha-helical protein
CDC46_RS15515	COG3234	Protein of unknown function (DUF1175)
CDC46_RS15520	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CDC46_RS15525	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDC46_RS15530	COG0085	RNA polymerase activity
CDC46_RS15535	COG0222	ribosome binding
CDC46_RS15540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDC46_RS15545	COG0081	regulation of translation
CDC46_RS15550	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDC46_RS15570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC46_RS15625	COG1349	DNA-binding transcription factor activity
CDC46_RS15635	COG3842	ATPase activity
CDC46_RS15640	COG3842	ATPase activity
CDC46_RS15650	COG0395	ABC-type sugar transport system, permease component
CDC46_RS15665	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDC46_RS15685	COG2336	PFAM SpoVT AbrB
CDC46_RS15690	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC46_RS15720	COG2205	protein histidine kinase activity
CDC46_RS15725	COG0745	RESPONSE REGULATOR receiver
CDC46_RS15750	COG0668	transmembrane transport
CDC46_RS15755	COG2814	Major facilitator Superfamily
CDC46_RS15790	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDC46_RS15795	COG2197	response regulator
CDC46_RS15850	COG0745	RESPONSE REGULATOR receiver
CDC46_RS15865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS15890	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC46_RS15890	COG0475	glutathione-regulated potassium exporter activity
CDC46_RS15925	COG1522	sequence-specific DNA binding
CDC46_RS16050	COG2925	Exonuclease
CDC46_RS16055	COG4302	ethanolamine ammonia-lyase activity
CDC46_RS16060	COG4303	Ethanolamine ammonia lyase large subunit
CDC46_RS16070	COG3284	Transcriptional regulator
CDC46_RS16080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC46_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS16125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC46_RS16135	COG0671	phosphoesterase, PA-phosphatase related
CDC46_RS16140	COG5001	Diguanylate cyclase
CDC46_RS16140	COG4251	negative regulation of phosphorylation
CDC46_RS16140	COG2203	Gaf domain
CDC46_RS16140	COG3706	GGDEF domain
CDC46_RS16210	COG1278	Cold shock
CDC46_RS16225	COG0493	'glutamate synthase
CDC46_RS16250	COG0457	Tetratricopeptide repeat
CDC46_RS16265	COG0529	Catalyzes the synthesis of activated sulfate
CDC46_RS16285	COG1301	dicarboxylic acid transport
CDC46_RS16340	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CDC46_RS16355	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC46_RS16360	COG2831	hemolysin activation secretion protein
CDC46_RS16365	COG3064	Membrane
CDC46_RS16365	COG3210	domain, Protein
CDC46_RS16365	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CDC46_RS16485	COG4221	oxidoreductase activity
CDC46_RS16575	COG3609	addiction module antidote protein, CC2985 family
CDC46_RS16645	COG3311	Transcriptional regulator
CDC46_RS16730	COG0737	Belongs to the 5'-nucleotidase family
CDC46_RS16740	COG2010	Cytochrome c
CDC46_RS16765	COG4654	Cytochrome c, class I
CDC46_RS16775	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC46_RS16790	COG0792	nuclease activity
CDC46_RS16805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC46_RS16830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC46_RS16840	COG4266	Belongs to the allantoicase family
CDC46_RS16845	COG1301	dicarboxylic acid transport
CDC46_RS16855	COG1739	Uncharacterized protein family UPF0029
CDC46_RS16870	COG0583	DNA-binding transcription factor activity
CDC46_RS16875	COG3960	tartronate-semialdehyde synthase activity
CDC46_RS16880	COG3622	Belongs to the hyi family
CDC46_RS16890	COG2084	Dehydrogenase
CDC46_RS16895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC46_RS16905	COG3916	Acyl-homoserine-lactone synthase
CDC46_RS16910	COG2197	response regulator
CDC46_RS16920	COG0210	DNA helicase
CDC46_RS16940	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC46_RS16945	COG0509	glycine decarboxylation via glycine cleavage system
CDC46_RS16950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC46_RS16950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC46_RS16955	COG1760	l-serine dehydratase
CDC46_RS16960	COG1297	OPT oligopeptide transporter protein
CDC46_RS16965	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDC46_RS16975	COG0683	leucine binding
CDC46_RS16980	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC46_RS16980	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC46_RS16980	COG0506	proline dehydrogenase activity
CDC46_RS16990	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CDC46_RS17020	COG0625	glutathione transferase activity
CDC46_RS17040	COG1832	CoA-binding protein
CDC46_RS17055	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC46_RS17060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDC46_RS17065	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDC46_RS17070	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDC46_RS17075	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDC46_RS17080	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDC46_RS17090	COG0356	it plays a direct role in the translocation of protons across the membrane
CDC46_RS17100	COG1475	DNA binding
CDC46_RS17110	COG0357	Ribosomal RNA small subunit methyltransferase G
CDC46_RS17115	COG0445	tRNA wobble uridine modification
CDC46_RS17140	COG3530	Putative quorum-sensing-regulated virulence factor
CDC46_RS17145	COG0583	DNA-binding transcription factor activity
CDC46_RS17200	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CDC46_RS17205	COG2267	carboxylic ester hydrolase activity
CDC46_RS17210	COG0789	Transcriptional regulator
CDC46_RS17215	COG2217	Heavy metal translocating P-type atpase
CDC46_RS17225	COG3047	cAMP biosynthetic process
CDC46_RS17240	COG2423	ornithine cyclodeaminase activity
CDC46_RS17255	COG3186	Phenylalanine-4-hydroxylase
CDC46_RS17260	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDC46_RS17285	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC46_RS17295	COG0737	Belongs to the 5'-nucleotidase family
CDC46_RS17300	COG0850	regulation of cytokinetic process
CDC46_RS17305	COG2894	cell division
CDC46_RS17310	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDC46_RS17315	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC46_RS17320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDC46_RS17330	COG1254	Belongs to the acylphosphatase family
CDC46_RS17340	COG1116	anion transmembrane transporter activity
CDC46_RS17350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC46_RS17385	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CDC46_RS17390	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CDC46_RS17395	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CDC46_RS17400	COG2205	protein histidine kinase activity
CDC46_RS17415	COG4251	negative regulation of phosphorylation
CDC46_RS17415	COG5001	Diguanylate cyclase
CDC46_RS17415	COG2203	Gaf domain
CDC46_RS17415	COG3706	GGDEF domain
CDC46_RS17435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC46_RS17440	COG0745	RESPONSE REGULATOR receiver
CDC46_RS17470	COG1959	2 iron, 2 sulfur cluster binding
CDC46_RS17485	COG2814	Major facilitator Superfamily
CDC46_RS17500	COG0642	Histidine kinase
CDC46_RS17520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS17525	COG1126	abc transporter atp-binding protein
CDC46_RS17530	COG0765	amino acid transport
CDC46_RS17545	COG0840	transmembrane signaling receptor activity
CDC46_RS17555	COG3781	membrane
CDC46_RS17670	COG0592	DNA-directed DNA polymerase activity
CDC46_RS17675	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC46_RS17690	COG1278	Cold shock
CDC46_RS17710	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDC46_RS17715	COG0477	Major facilitator Superfamily
CDC46_RS17720	COG4191	Histidine kinase
CDC46_RS17730	COG4377	Putative membrane peptidase family (DUF2324)
CDC46_RS17740	COG5002	protein histidine kinase activity
CDC46_RS17740	COG5001	Diguanylate cyclase
CDC46_RS17740	COG3447	MASE1 domain protein
CDC46_RS17785	COG0038	chloride channel
CDC46_RS17800	COG1881	PFAM PEBP family protein
CDC46_RS17830	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC46_RS17855	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS17865	COG1024	Enoyl-CoA hydratase
CDC46_RS17870	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS17910	COG1760	l-serine dehydratase
CDC46_RS17940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS17945	COG0477	Major facilitator Superfamily
CDC46_RS17965	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC46_RS17980	COG1902	pentaerythritol trinitrate reductase activity
CDC46_RS17980	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC46_RS17985	COG2181	nitrate reductase activity
CDC46_RS17985	COG0247	lactate metabolic process
CDC46_RS17990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CDC46_RS18000	COG4638	Rieske (2fe-2S)
CDC46_RS18020	COG4175	Glycine betaine
CDC46_RS18025	COG4176	ABC-type proline glycine betaine transport system permease component
CDC46_RS18065	COG0477	Major facilitator Superfamily
CDC46_RS18070	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDC46_RS18075	COG3657	addiction module killer protein
CDC46_RS18080	COG2814	Major facilitator Superfamily
CDC46_RS18115	COG3209	COG3209 Rhs family protein
CDC46_RS18125	COG4974	Belongs to the 'phage' integrase family
CDC46_RS18135	COG3209	COG3209 Rhs family protein
CDC46_RS18190	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDC46_RS18205	COG0714	Associated with various cellular activities
CDC46_RS18220	COG0288	reversible hydration of carbon dioxide
CDC46_RS18225	COG0659	secondary active sulfate transmembrane transporter activity
CDC46_RS18275	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CDC46_RS18350	COG4677	pectinesterase activity
CDC46_RS18365	COG4968	Prepilin-type N-terminal cleavage methylation domain
CDC46_RS18375	COG4796	Type ii and iii secretion system protein
CDC46_RS18400	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDC46_RS18460	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CDC46_RS18470	COG0534	Mate efflux family protein
CDC46_RS18475	COG3251	PFAM MbtH domain protein
CDC46_RS18485	COG0529	Catalyzes the synthesis of activated sulfate
CDC46_RS18520	COG1104	cysteine desulfurase activity
CDC46_RS18585	COG2706	6-phosphogluconolactonase activity
CDC46_RS18655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC46_RS18665	COG0028	Belongs to the TPP enzyme family
CDC46_RS18680	COG1607	acyl-coa hydrolase
CDC46_RS18700	COG3039	Transposase
CDC46_RS18740	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC46_RS18820	COG1846	Transcriptional regulator
CDC46_RS18825	COG1024	Enoyl-CoA hydratase
CDC46_RS18830	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS18835	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS18860	COG0657	acetylesterase activity
CDC46_RS18870	COG2814	Major facilitator Superfamily
CDC46_RS18880	COG1640	4-alpha-glucanotransferase
CDC46_RS18910	COG0366	Alpha amylase catalytic
CDC46_RS18915	COG0297	glycogen (starch) synthase activity
CDC46_RS18920	COG3720	iron ion transport
CDC46_RS18925	COG4771	TonB-dependent receptor
CDC46_RS18935	COG3634	alkyl hydroperoxide reductase activity
CDC46_RS18940	COG0735	belongs to the Fur family
CDC46_RS18960	COG1918	ferrous iron import across plasma membrane
CDC46_RS18960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CDC46_RS18970	COG5001	Diguanylate cyclase
CDC46_RS18970	COG3447	MASE1 domain protein
CDC46_RS18970	COG5002	protein histidine kinase activity
CDC46_RS18980	COG0840	transmembrane signaling receptor activity
CDC46_RS19000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC46_RS19015	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC46_RS19025	COG0456	acetyltransferase
CDC46_RS19025	COG0454	-acetyltransferase
CDC46_RS19085	COG3979	chitinase
CDC46_RS19095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CDC46_RS19115	COG3706	GGDEF domain
CDC46_RS19120	COG0531	amino acid
CDC46_RS19125	COG0534	Mate efflux family protein
CDC46_RS19140	COG2197	response regulator
CDC46_RS19160	COG1215	transferase activity, transferring glycosyl groups
CDC46_RS19175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS19180	COG2274	protein secretion by the type I secretion system
CDC46_RS19215	COG0840	transmembrane signaling receptor activity
CDC46_RS19235	COG2070	2-Nitropropane dioxygenase
CDC46_RS19240	COG0583	DNA-binding transcription factor activity
CDC46_RS19245	COG1695	Transcriptional regulator
CDC46_RS19265	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC46_RS19275	COG0745	RESPONSE REGULATOR receiver
CDC46_RS19280	COG2205	protein histidine kinase activity
CDC46_RS19295	COG0589	response to stress
CDC46_RS19310	COG0789	Transcriptional regulator
CDC46_RS19320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC46_RS19345	COG1764	response to oxidative stress
CDC46_RS19360	COG0473	3-isopropylmalate dehydrogenase activity
CDC46_RS19390	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC46_RS19395	COG2188	Transcriptional regulator
CDC46_RS19400	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS19405	COG2197	response regulator
CDC46_RS19425	COG1815	bacterial-type flagellum-dependent cell motility
CDC46_RS19435	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CDC46_RS19440	COG1749	Flagellar hook protein flgE
CDC46_RS19445	COG4787	bacterial-type flagellum-dependent cell motility
CDC46_RS19455	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CDC46_RS19460	COG1706	bacterial-type flagellum-dependent cell motility
CDC46_RS19470	COG1256	bacterial-type flagellum assembly
CDC46_RS19490	COG2226	methyltransferase
CDC46_RS19505	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC46_RS19510	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS19520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC46_RS19540	COG2986	histidine ammonia-lyase
CDC46_RS19550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC46_RS19560	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC46_RS19570	COG0204	Acyl-transferase
CDC46_RS19585	COG1987	bacterial-type flagellum assembly
CDC46_RS19590	COG1338	Plays a role in the flagellum-specific transport system
CDC46_RS19620	COG2197	response regulator
CDC46_RS19645	COG1846	Transcriptional regulator
CDC46_RS19660	COG1677	Flagellar hook-basal body complex protein FliE
CDC46_RS19670	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDC46_RS19680	COG1157	protein secretion by the type III secretion system
CDC46_RS19705	COG3706	GGDEF domain
CDC46_RS19705	COG2203	Gaf domain
CDC46_RS19705	COG5001	Diguanylate cyclase
CDC46_RS19705	COG4251	negative regulation of phosphorylation
CDC46_RS19715	COG4251	negative regulation of phosphorylation
CDC46_RS19715	COG5001	Diguanylate cyclase
CDC46_RS19715	COG2203	Gaf domain
CDC46_RS19715	COG3706	GGDEF domain
CDC46_RS19780	COG2223	nitrite transmembrane transporter activity
CDC46_RS19795	COG4774	siderophore transport
CDC46_RS19810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDC46_RS19815	COG2423	ornithine cyclodeaminase activity
CDC46_RS19820	COG4264	IucA IucC family
CDC46_RS19825	COG2814	Major facilitator Superfamily
CDC46_RS19830	COG4264	IucA IucC family
CDC46_RS19835	COG4264	IucA IucC family
CDC46_RS19845	COG0019	diaminopimelate decarboxylase activity
CDC46_RS19870	COG2814	Major facilitator Superfamily
CDC46_RS19895	COG0583	DNA-binding transcription factor activity
CDC46_RS19940	COG1902	pentaerythritol trinitrate reductase activity
CDC46_RS20050	COG1459	type II secretion system
CDC46_RS20065	COG2165	general secretion pathway protein
CDC46_RS20105	COG3328	transposase activity
CDC46_RS20110	COG1126	abc transporter atp-binding protein
CDC46_RS20115	COG0765	amino acid transport
CDC46_RS20120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS20125	COG1522	sequence-specific DNA binding
CDC46_RS20130	COG2423	ornithine cyclodeaminase activity
CDC46_RS20140	COG0546	phosphoglycolate phosphatase activity
CDC46_RS20155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC46_RS20190	COG0537	adenosine 5'-monophosphoramidase activity
CDC46_RS20235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC46_RS20245	COG0840	transmembrane signaling receptor activity
CDC46_RS20260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CDC46_RS20280	COG0668	transmembrane transport
CDC46_RS20305	COG3706	GGDEF domain
CDC46_RS20310	COG1914	H( )-stimulated, divalent metal cation uptake system
CDC46_RS20315	COG0443	Heat shock 70 kDa protein
CDC46_RS20335	COG2910	NAD(P)H-binding
CDC46_RS20355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS20370	COG0308	aminopeptidase N
CDC46_RS20380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC46_RS20440	COG0402	S-adenosylhomocysteine deaminase activity
CDC46_RS20505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC46_RS20545	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CDC46_RS20595	COG5297	Belongs to the glycosyl hydrolase family 6
CDC46_RS20620	COG0300	oxidoreductase activity
CDC46_RS20685	COG0784	Response regulator, receiver
CDC46_RS20685	COG0835	chemotaxis
CDC46_RS20710	COG1404	Belongs to the peptidase S8 family
CDC46_RS20715	COG3396	Phenylacetate-CoA oxygenase
CDC46_RS20720	COG3460	Phenylacetate-CoA oxygenase
CDC46_RS20725	COG3396	Phenylacetate-CoA oxygenase
CDC46_RS20730	COG2151	metal-sulfur cluster biosynthetic enzyme
CDC46_RS20735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC46_RS20765	COG0778	Nitroreductase
CDC46_RS20770	COG1797	cobyrinic acid a,c-diamide synthase activity
CDC46_RS20805	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CDC46_RS20815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC46_RS20815	COG1648	precorrin-2 dehydrogenase activity
CDC46_RS20835	COG3411	Ferredoxin
CDC46_RS20840	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CDC46_RS20875	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CDC46_RS20880	COG4941	Belongs to the sigma-70 factor family
CDC46_RS20895	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CDC46_RS20900	COG3251	PFAM MbtH domain protein
CDC46_RS20920	COG1522	sequence-specific DNA binding
CDC46_RS20925	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CDC46_RS20935	COG1024	Enoyl-CoA hydratase
CDC46_RS20950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC46_RS20955	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS20965	COG5002	protein histidine kinase activity
CDC46_RS20970	COG0745	RESPONSE REGULATOR receiver
CDC46_RS21000	COG1335	isochorismatase
CDC46_RS21010	COG2814	Major facilitator Superfamily
CDC46_RS21025	COG0519	Catalyzes the synthesis of GMP from XMP
CDC46_RS21030	COG2807	transmembrane transport
CDC46_RS21050	COG1024	Enoyl-CoA hydratase
CDC46_RS21080	COG0583	DNA-binding transcription factor activity
CDC46_RS21085	COG0259	pyridoxamine-phosphate oxidase activity
CDC46_RS21090	COG0019	diaminopimelate decarboxylase activity
CDC46_RS21095	COG0134	indole-3-glycerol-phosphate synthase activity
CDC46_RS21100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC46_RS21130	COG1960	acyl-CoA dehydrogenase activity
CDC46_RS21150	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CDC46_RS21165	COG3483	tryptophan 2,3-dioxygenase activity
CDC46_RS21175	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDC46_RS21190	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDC46_RS21195	COG1690	Belongs to the RtcB family
CDC46_RS21280	COG1858	cytochrome C peroxidase
CDC46_RS21285	COG1730	sister chromatid segregation
CDC46_RS21300	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CDC46_RS21330	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CDC46_RS21460	COG1649	PFAM Uncharacterised BCR, COG1649
CDC46_RS21545	COG2197	response regulator
CDC46_RS21550	COG3916	Acyl-homoserine-lactone synthase
CDC46_RS21565	COG0525	valine-tRNA ligase activity
CDC46_RS21590	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS21595	COG2192	nodulation
CDC46_RS21610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC46_RS21610	COG3321	synthase
CDC46_RS21610	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS21610	COG0300	oxidoreductase activity
CDC46_RS21610	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS21625	COG0436	Aminotransferase
CDC46_RS21640	COG2814	Major facilitator Superfamily
CDC46_RS21655	COG0587	DNA-directed DNA polymerase activity
CDC46_RS21660	COG3620	sequence-specific DNA binding
CDC46_RS21665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CDC46_RS21675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC46_RS21690	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC46_RS21705	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC46_RS21710	COG4206	TonB-dependent receptor
CDC46_RS21725	COG0579	oxidoreductase
CDC46_RS21735	COG1309	transcriptional regulator
CDC46_RS21760	COG0697	spore germination
CDC46_RS21770	COG0583	DNA-binding transcription factor activity
CDC46_RS21780	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC46_RS21785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC46_RS21795	COG2271	Major facilitator Superfamily
CDC46_RS21800	COG4948	Mandelate Racemase Muconate Lactonizing
CDC46_RS21805	COG2721	sulfolactate sulfo-lyase activity
CDC46_RS21810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC46_RS21825	COG2271	Major facilitator Superfamily
CDC46_RS21830	COG1056	cytidyltransferase-related domain
CDC46_RS21830	COG1051	belongs to the nudix hydrolase family
CDC46_RS21855	COG0840	transmembrane signaling receptor activity
CDC46_RS21860	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CDC46_RS21905	COG1595	DNA-templated transcription, initiation
CDC46_RS21915	COG2197	response regulator
CDC46_RS21920	COG0745	RESPONSE REGULATOR receiver
CDC46_RS21960	COG4790	Type iii secretion
CDC46_RS21975	COG4789	Type iii secretion
CDC46_RS21980	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDC46_RS22025	COG2207	Transcriptional regulator
CDC46_RS22030	COG1450	Type ii and iii secretion system protein
CDC46_RS22035	COG4886	Leucine-rich repeat (LRR) protein
CDC46_RS22125	COG1942	4-Oxalocrotonate Tautomerase
CDC46_RS22130	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDC46_RS22135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC46_RS22140	COG2271	Major facilitator Superfamily
CDC46_RS22150	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDC46_RS22165	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC46_RS22210	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC46_RS22215	COG0583	DNA-binding transcription factor activity
CDC46_RS22235	COG2853	Lipoprotein
CDC46_RS22245	COG0745	RESPONSE REGULATOR receiver
CDC46_RS22300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS22320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS22325	COG1126	abc transporter atp-binding protein
CDC46_RS22330	COG0765	amino acid transport
CDC46_RS22340	COG4221	oxidoreductase activity
CDC46_RS22345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC46_RS22355	COG1984	allophanate hydrolase subunit 2
CDC46_RS22360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC46_RS22370	COG0511	ligase activity, forming carbon-carbon bonds
CDC46_RS22380	COG0436	Aminotransferase
CDC46_RS22385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC46_RS22395	COG3265	gluconokinase activity
CDC46_RS22400	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS22405	COG1063	alcohol dehydrogenase
CDC46_RS22445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS22485	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CDC46_RS22490	COG3604	Transcriptional regulator
CDC46_RS22495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC46_RS22505	COG1396	sequence-specific DNA binding
CDC46_RS22535	COG3154	lipid carrier protein
CDC46_RS22540	COG0826	peptidase U32
CDC46_RS22560	COG2223	nitrite transmembrane transporter activity
CDC46_RS22570	COG1140	nitrate reductase beta subunit
CDC46_RS22575	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CDC46_RS22580	COG2181	nitrate reductase activity
CDC46_RS22585	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC46_RS22590	COG3850	Histidine kinase
CDC46_RS22595	COG2197	response regulator
CDC46_RS22615	COG0352	thiamine-phosphate diphosphorylase activity
CDC46_RS22640	COG1999	signal sequence binding
CDC46_RS22665	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CDC46_RS22670	COG1301	dicarboxylic acid transport
CDC46_RS22680	COG0583	DNA-binding transcription factor activity
CDC46_RS22710	COG1086	Polysaccharide biosynthesis protein
CDC46_RS22720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC46_RS22730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDC46_RS22750	COG0110	maltose O-acetyltransferase activity
CDC46_RS22765	COG2244	polysaccharide biosynthetic process
CDC46_RS22785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC46_RS22790	COG1596	polysaccharide export
CDC46_RS22835	COG0840	transmembrane signaling receptor activity
CDC46_RS22885	COG3220	belongs to the UPF0276 family
CDC46_RS22895	COG2259	Doxx family
CDC46_RS22920	COG0745	RESPONSE REGULATOR receiver
CDC46_RS22945	COG2223	nitrite transmembrane transporter activity
CDC46_RS22960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC46_RS22965	COG5001	Diguanylate cyclase
CDC46_RS22965	COG3300	MHYT domain
CDC46_RS22970	COG3158	transport of potassium into the cell
CDC46_RS22975	COG1278	Cold shock
CDC46_RS22990	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC46_RS23000	COG4689	acetoacetate decarboxylase
CDC46_RS23005	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS23015	COG0673	inositol 2-dehydrogenase activity
CDC46_RS23070	COG3210	domain, Protein
CDC46_RS23080	COG2831	hemolysin activation secretion protein
CDC46_RS23090	COG0673	inositol 2-dehydrogenase activity
CDC46_RS23150	COG4964	Belongs to the GSP D family
CDC46_RS23190	COG2197	response regulator
CDC46_RS23215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC46_RS23220	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC46_RS23225	COG1877	trehalose-phosphatase activity
CDC46_RS23235	COG1846	Transcriptional regulator
CDC46_RS23240	COG1764	response to oxidative stress
CDC46_RS23255	COG0583	DNA-binding transcription factor activity
CDC46_RS23260	COG0657	acetylesterase activity
CDC46_RS23265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS23310	COG2030	dehydratase
CDC46_RS23330	COG1064	alcohol dehydrogenase
CDC46_RS23345	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC46_RS23415	COG2197	response regulator
CDC46_RS23425	COG2066	Belongs to the glutaminase family
CDC46_RS23430	COG4149	molybdate abc transporter
CDC46_RS23435	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC46_RS23470	COG1942	4-Oxalocrotonate Tautomerase
CDC46_RS23490	COG3300	MHYT domain
CDC46_RS23490	COG5001	Diguanylate cyclase
CDC46_RS23510	COG3813	Protein conserved in bacteria
CDC46_RS23525	COG0745	RESPONSE REGULATOR receiver
CDC46_RS23530	COG2205	protein histidine kinase activity
CDC46_RS23560	COG1858	cytochrome C peroxidase
CDC46_RS23580	COG1253	flavin adenine dinucleotide binding
CDC46_RS23585	COG1858	cytochrome C peroxidase
CDC46_RS23615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS23615	COG2205	protein histidine kinase activity
CDC46_RS23625	COG3039	Transposase
CDC46_RS23645	COG2274	protein secretion by the type I secretion system
CDC46_RS23670	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CDC46_RS23685	COG0800	Aldolase
CDC46_RS23690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC46_RS23695	COG2197	response regulator
CDC46_RS23700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDC46_RS23725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC46_RS23765	COG1294	oxidase, subunit
CDC46_RS23770	COG1271	oxidase subunit
CDC46_RS23775	COG5001	Diguanylate cyclase
CDC46_RS23775	COG3300	MHYT domain
CDC46_RS23780	COG0840	transmembrane signaling receptor activity
CDC46_RS23790	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC46_RS23800	COG0534	Mate efflux family protein
CDC46_RS23830	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC46_RS23840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC46_RS23845	COG2223	nitrite transmembrane transporter activity
CDC46_RS23850	COG0840	transmembrane signaling receptor activity
CDC46_RS23855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC46_RS23865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC46_RS23880	COG2267	carboxylic ester hydrolase activity
CDC46_RS23890	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC46_RS23895	COG0436	Aminotransferase
CDC46_RS23900	COG0473	3-isopropylmalate dehydrogenase activity
CDC46_RS23900	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC46_RS23935	COG2951	lytic endotransglycosylase activity
CDC46_RS23945	COG1271	oxidase subunit
CDC46_RS23950	COG1294	oxidase, subunit
CDC46_RS23955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC46_RS24020	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDC46_RS24040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC46_RS24045	COG0730	response to heat
CDC46_RS24050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC46_RS24060	COG0583	DNA-binding transcription factor activity
CDC46_RS24065	COG0730	response to heat
CDC46_RS24100	COG0668	transmembrane transport
CDC46_RS24105	COG1742	UPF0060 membrane protein
CDC46_RS24125	COG0477	Major facilitator Superfamily
CDC46_RS24130	COG0114	fumarate hydratase activity
CDC46_RS24150	COG4580	involved in the transport of maltose and maltodextrins
CDC46_RS24155	COG1621	beta-fructofuranosidase activity
CDC46_RS24165	COG1609	Transcriptional regulator
CDC46_RS24195	COG4969	Belongs to the N-Me-Phe pilin family
CDC46_RS24205	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CDC46_RS24225	COG3766	membrane
CDC46_RS24230	COG0683	leucine binding
CDC46_RS24265	COG3209	COG3209 Rhs family protein
CDC46_RS24275	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC46_RS24335	COG0251	oxidation-reduction process
CDC46_RS24345	COG1522	sequence-specific DNA binding
CDC46_RS24350	COG0640	Transcriptional regulator
CDC46_RS24365	COG1280	lysine exporter protein (LysE YggA)
CDC46_RS24370	COG0251	oxidation-reduction process
CDC46_RS24385	COG0583	DNA-binding transcription factor activity
CDC46_RS24395	COG2814	Major facilitator Superfamily
CDC46_RS24425	COG3209	COG3209 Rhs family protein
CDC46_RS24435	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC46_RS24495	COG0251	oxidation-reduction process
CDC46_RS24505	COG1522	sequence-specific DNA binding
CDC46_RS24510	COG0640	Transcriptional regulator
CDC46_RS24525	COG1280	lysine exporter protein (LysE YggA)
CDC46_RS24530	COG0251	oxidation-reduction process
CDC46_RS24545	COG0583	DNA-binding transcription factor activity
CDC46_RS24555	COG2814	Major facilitator Superfamily
CDC46_RS24570	COG0840	transmembrane signaling receptor activity
CDC46_RS24575	COG0567	Dehydrogenase, E1 component
CDC46_RS24580	COG0204	Acyl-transferase
CDC46_RS24595	COG4263	nitrous-oxide reductase activity
CDC46_RS24660	COG2824	Alkylphosphonate utilization operon protein PhnA
CDC46_RS24670	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC46_RS24680	COG0762	integral membrane protein
CDC46_RS24700	COG1191	sigma factor activity
CDC46_RS24715	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDC46_RS24725	COG1309	transcriptional regulator
CDC46_RS24730	COG2271	Major facilitator Superfamily
CDC46_RS24735	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC46_RS24740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC46_RS24745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS24750	COG3185	4-Hydroxyphenylpyruvate dioxygenase
CDC46_RS24750	COG1082	Xylose isomerase domain protein TIM barrel
CDC46_RS24755	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC46_RS24760	COG0745	RESPONSE REGULATOR receiver
CDC46_RS24765	COG2201	protein-glutamate methylesterase activity
CDC46_RS24770	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CDC46_RS24780	COG0840	transmembrane signaling receptor activity
CDC46_RS24785	COG0835	chemotaxis
CDC46_RS24795	COG0745	RESPONSE REGULATOR receiver
CDC46_RS24800	COG1360	Flagellar Motor Protein
CDC46_RS24830	COG0477	Major facilitator Superfamily
CDC46_RS24835	COG2267	carboxylic ester hydrolase activity
CDC46_RS24840	COG0318	PFAM AMP-dependent synthetase and ligase
CDC46_RS24840	COG1028	Short-chain dehydrogenase reductase Sdr
CDC46_RS24840	COG0300	oxidoreductase activity
CDC46_RS24840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC46_RS24840	COG3321	synthase
CDC46_RS24845	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC46_RS24855	COG0644	oxidoreductase
CDC46_RS24860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDC46_RS24865	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CDC46_RS24895	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS24895	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC46_RS24930	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC46_RS24930	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC46_RS24950	COG2205	protein histidine kinase activity
CDC46_RS24975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC46_RS24985	COG0469	pyruvate kinase activity
CDC46_RS24995	COG0583	DNA-binding transcription factor activity
CDC46_RS25005	COG2205	protein histidine kinase activity
CDC46_RS25010	COG0745	RESPONSE REGULATOR receiver
CDC46_RS25030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CDC46_RS25055	COG1136	(ABC) transporter
CDC46_RS25060	COG1136	(ABC) transporter
CDC46_RS25060	COG0577	efflux transmembrane transporter activity
CDC46_RS25105	COG0667	Aldo Keto reductase
CDC46_RS25155	COG2885	chlorophyll binding
CDC46_RS25165	COG2267	carboxylic ester hydrolase activity
CDC46_RS25175	COG0151	Belongs to the GarS family
CDC46_RS25195	COG2192	nodulation
CDC46_RS25215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC46_RS25215	COG4651	solute:proton antiporter activity
CDC46_RS25260	COG3256	nitric oxide reductase
CDC46_RS25265	COG2188	Transcriptional regulator
CDC46_RS25275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC46_RS25310	COG0583	DNA-binding transcription factor activity
CDC46_RS25365	COG0705	Rhomboid family
CDC46_RS25385	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CDC46_RS25410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC46_RS25455	COG3210	domain, Protein
CDC46_RS25490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC46_RS25495	COG0642	Histidine kinase
CDC46_RS25515	COG0837	glucose binding
CDC46_RS25525	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CDC46_RS25535	COG0589	response to stress
CDC46_RS25550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC46_RS25555	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC46_RS25565	COG1845	cytochrome c oxidase, subunit III
CDC46_RS25590	COG2271	Major facilitator Superfamily
CDC46_RS25605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC46_RS25615	COG0765	amino acid transport
CDC46_RS25620	COG0010	Belongs to the arginase family
CDC46_RS25625	COG2197	response regulator
CDC46_RS25665	COG2826	transposase and inactivated derivatives, IS30 family
CDC46_RS25670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC46_RS25670	COG2022	thiamine diphosphate biosynthetic process
CDC46_RS25675	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS25685	COG0583	DNA-binding transcription factor activity
CDC46_RS25690	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC46_RS25695	COG2814	Major facilitator Superfamily
CDC46_RS25710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC46_RS25770	COG1012	belongs to the aldehyde dehydrogenase family
CDC46_RS25775	COG0473	3-isopropylmalate dehydrogenase activity
CDC46_RS25785	COG2271	Major facilitator Superfamily
CDC46_RS25790	COG2721	sulfolactate sulfo-lyase activity
CDC46_RS25800	COG1609	Transcriptional regulator
CDC46_RS25805	COG1475	DNA binding
CDC46_RS25815	COG3969	phosphoadenosine phosphosulfate
CDC46_RS25820	COG5295	Hep Hag repeat protein
CDC46_RS25820	COG5295	Hep Hag repeat protein
CDC46_RS25830	COG2205	protein histidine kinase activity
CDC46_RS25830	COG0784	Response regulator, receiver
CDC46_RS25835	COG3706	GGDEF domain
CDC46_RS25835	COG4251	negative regulation of phosphorylation
CDC46_RS25835	COG5001	Diguanylate cyclase
CDC46_RS25835	COG2203	Gaf domain
CDC46_RS25840	COG2801	Transposase and inactivated derivatives
CDC46_RS25855	COG2801	Transposase and inactivated derivatives
CDC46_RS25870	COG4213	ABC transporter substrate-binding protein
CDC46_RS25875	COG1129	ABC transporter
CDC46_RS25880	COG4214	carbohydrate transport
CDC46_RS25890	COG1609	Transcriptional regulator
CDC46_RS25980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC46_RS25990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC46_RS26000	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDC46_RS26025	COG2204	response regulator
CDC46_RS26040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC46_RS26065	COG2205	protein histidine kinase activity
CDC46_RS26075	COG2252	PERMEase