locus-tag	class	description
CDC45_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDC45_RS00010	COG0594	ribonuclease P activity
CDC45_RS00015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDC45_RS00020	COG0706	membrane insertase activity
CDC45_RS00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC45_RS00040	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDC45_RS00050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC45_RS00055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS00060	COG1309	transcriptional regulator
CDC45_RS00075	COG3384	dioxygenase
CDC45_RS00080	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC45_RS00090	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CDC45_RS00095	COG0745	RESPONSE REGULATOR receiver
CDC45_RS00105	COG3622	Belongs to the hyi family
CDC45_RS00120	COG1966	Carbon starvation protein
CDC45_RS00125	COG2879	small protein
CDC45_RS00145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC45_RS00155	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDC45_RS00175	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC45_RS00180	COG1595	DNA-templated transcription, initiation
CDC45_RS00210	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CDC45_RS00220	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CDC45_RS00225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CDC45_RS00230	COG0747	negative chemotaxis
CDC45_RS00245	COG0523	cobalamin synthesis protein
CDC45_RS00265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CDC45_RS00270	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC45_RS00280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC45_RS00295	COG0154	amidase activity
CDC45_RS00300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC45_RS00305	COG1077	Cell shape determining protein MreB Mrl
CDC45_RS00310	COG1792	Involved in formation and maintenance of cell shape
CDC45_RS00320	COG0768	penicillin binding
CDC45_RS00325	COG0772	Belongs to the SEDS family
CDC45_RS00330	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS00335	COG0583	DNA-binding transcription factor activity
CDC45_RS00350	COG0758	DNA mediated transformation
CDC45_RS00355	COG1652	LysM domain
CDC45_RS00360	COG0242	peptide deformylase activity
CDC45_RS00370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC45_RS00380	COG0501	Belongs to the peptidase M48B family
CDC45_RS00395	COG5000	phosphorelay sensor kinase activity
CDC45_RS00400	COG2204	response regulator
CDC45_RS00425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC45_RS00430	COG3246	L-lysine catabolic process to acetate
CDC45_RS00440	COG0617	tRNA 3'-terminal CCA addition
CDC45_RS00460	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDC45_RS00470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDC45_RS00475	COG1950	PFAM Membrane protein of
CDC45_RS00480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDC45_RS00495	COG1785	Belongs to the alkaline phosphatase family
CDC45_RS00500	COG1785	Belongs to the alkaline phosphatase family
CDC45_RS00510	COG0351	phosphomethylpyrimidine kinase
CDC45_RS00550	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CDC45_RS00560	COG2022	thiamine diphosphate biosynthetic process
CDC45_RS00580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDC45_RS00585	COG2070	2-Nitropropane dioxygenase
CDC45_RS00620	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS00655	COG1522	sequence-specific DNA binding
CDC45_RS00665	COG0517	IMP dehydrogenase activity
CDC45_RS00685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDC45_RS00695	COG1560	Kdo2-lipid A biosynthetic process
CDC45_RS00700	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDC45_RS00705	COG2326	polyphosphate kinase activity
CDC45_RS00710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDC45_RS00715	COG0708	Exodeoxyribonuclease III
CDC45_RS00720	COG4682	membrane
CDC45_RS00725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDC45_RS00745	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CDC45_RS00770	COG0697	spore germination
CDC45_RS00785	COG2223	nitrite transmembrane transporter activity
CDC45_RS00810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC45_RS00815	COG0583	DNA-binding transcription factor activity
CDC45_RS00820	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS00830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS00835	COG1131	(ABC) transporter
CDC45_RS00840	COG0842	Transport permease protein
CDC45_RS00855	COG0493	'glutamate synthase
CDC45_RS00880	COG0546	phosphoglycolate phosphatase activity
CDC45_RS00880	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC45_RS00885	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC45_RS00890	COG0037	tRNA processing
CDC45_RS00900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDC45_RS00905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDC45_RS00915	COG0589	response to stress
CDC45_RS00935	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
CDC45_RS00940	COG0589	response to stress
CDC45_RS00970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC45_RS00975	COG3851	Histidine kinase
CDC45_RS00980	COG2197	response regulator
CDC45_RS00990	COG1063	alcohol dehydrogenase
CDC45_RS00995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CDC45_RS01015	COG3038	cytochrome b561
CDC45_RS01030	COG0071	Belongs to the small heat shock protein (HSP20) family
CDC45_RS01035	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDC45_RS01040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC45_RS01050	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CDC45_RS01105	COG1733	regulation of RNA biosynthetic process
CDC45_RS01120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC45_RS01120	COG0519	Catalyzes the synthesis of GMP from XMP
CDC45_RS01125	COG0583	DNA-binding transcription factor activity
CDC45_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS01135	COG2814	Major facilitator Superfamily
CDC45_RS01140	COG0667	Aldo Keto reductase
CDC45_RS01150	COG1254	Belongs to the acylphosphatase family
CDC45_RS01165	COG4650	regulator
CDC45_RS01175	COG1690	Belongs to the RtcB family
CDC45_RS01180	COG3541	Predicted nucleotidyltransferase
CDC45_RS01185	COG0430	RNA-3'-phosphate cyclase activity
CDC45_RS01195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS01240	COG1703	isobutyryl-CoA mutase activity
CDC45_RS01240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC45_RS01240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC45_RS01270	COG0583	DNA-binding transcription factor activity
CDC45_RS01275	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC45_RS01315	COG3328	transposase activity
CDC45_RS01335	COG0596	Alpha beta hydrolase
CDC45_RS01345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC45_RS01365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC45_RS01380	COG4770	biotin carboxylase activity
CDC45_RS01385	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDC45_RS01390	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDC45_RS01400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDC45_RS01405	COG3012	SEC-C Motif Domain Protein
CDC45_RS01410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC45_RS01425	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS01430	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS01435	COG0183	Belongs to the thiolase family
CDC45_RS01450	COG0288	reversible hydration of carbon dioxide
CDC45_RS01455	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CDC45_RS01460	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS01465	COG0789	Transcriptional regulator
CDC45_RS01475	COG2329	Antibiotic biosynthesis monooxygenase
CDC45_RS01485	COG4221	oxidoreductase activity
CDC45_RS01490	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDC45_RS01500	COG0018	arginyl-trna synthetase
CDC45_RS01525	COG2197	response regulator
CDC45_RS01535	COG1410	methionine synthase
CDC45_RS01535	COG0646	methionine synthase
CDC45_RS01555	COG2267	carboxylic ester hydrolase activity
CDC45_RS01585	COG1024	Enoyl-CoA hydratase
CDC45_RS01610	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDC45_RS01620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDC45_RS01625	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CDC45_RS01625	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CDC45_RS01630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC45_RS01660	COG3511	phospholipase C
CDC45_RS01675	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDC45_RS01680	COG0321	lipoyl(octanoyl) transferase activity
CDC45_RS01690	COG0583	DNA-binding transcription factor activity
CDC45_RS01695	COG2921	Belongs to the UPF0250 family
CDC45_RS01700	COG1686	Belongs to the peptidase S11 family
CDC45_RS01710	COG3411	Ferredoxin
CDC45_RS01715	COG1301	dicarboxylic acid transport
CDC45_RS01725	COG2204	response regulator
CDC45_RS01735	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CDC45_RS01755	COG0606	chelatase, subunit chli
CDC45_RS01780	COG0004	ammonium transporteR
CDC45_RS01790	COG0189	ligase activity
CDC45_RS01800	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC45_RS01805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC45_RS01825	COG0793	Belongs to the peptidase S41A family
CDC45_RS01830	COG0588	phosphoglycerate mutase activity
CDC45_RS01835	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDC45_RS01840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDC45_RS01845	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CDC45_RS01850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDC45_RS01860	COG1040	competence protein
CDC45_RS01865	COG2226	methyltransferase
CDC45_RS01880	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC45_RS01885	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CDC45_RS01915	COG1612	heme a metabolic process
CDC45_RS01920	COG0109	protoheme IX farnesyltransferase activity
CDC45_RS01925	COG1999	signal sequence binding
CDC45_RS01930	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC45_RS01935	COG3300	MHYT domain
CDC45_RS01935	COG5001	Diguanylate cyclase
CDC45_RS01945	COG1741	Belongs to the pirin family
CDC45_RS01950	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC45_RS01955	COG1116	anion transmembrane transporter activity
CDC45_RS01960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC45_RS01965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC45_RS01975	COG3707	response regulator
CDC45_RS01985	COG0625	glutathione transferase activity
CDC45_RS02000	COG0612	Peptidase, M16
CDC45_RS02005	COG0612	Peptidase, M16
CDC45_RS02010	COG0742	ribosomal rna small subunit methyltransferase
CDC45_RS02015	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDC45_RS02020	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC45_RS02030	COG0193	aminoacyl-tRNA hydrolase activity
CDC45_RS02035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDC45_RS02040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC45_RS02050	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDC45_RS02055	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CDC45_RS02065	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDC45_RS02075	COG1194	a g-specific adenine glycosylase
CDC45_RS02085	COG1660	Displays ATPase and GTPase activities
CDC45_RS02095	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CDC45_RS02105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDC45_RS02110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC45_RS02115	COG1137	ATPase activity
CDC45_RS02130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDC45_RS02155	COG0693	protein deglycase activity
CDC45_RS02160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDC45_RS02165	COG1280	lysine exporter protein (LysE YggA)
CDC45_RS02180	COG2814	Major facilitator Superfamily
CDC45_RS02185	COG0629	single-stranded DNA binding
CDC45_RS02215	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC45_RS02240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC45_RS02255	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS02270	COG2391	methyltransferase activity
CDC45_RS02285	COG3265	gluconokinase activity
CDC45_RS02290	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS02320	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC45_RS02320	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC45_RS02325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CDC45_RS02340	COG0700	Nucleoside recognition
CDC45_RS02345	COG1238	metal cluster binding
CDC45_RS02360	COG4178	(ABC) transporter
CDC45_RS02370	COG2226	methyltransferase
CDC45_RS02385	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC45_RS02410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDC45_RS02420	COG0494	nUDIX hydrolase
CDC45_RS02425	COG3568	Endonuclease Exonuclease Phosphatase
CDC45_RS02430	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC45_RS02445	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS02450	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC45_RS02450	COG1024	Enoyl-CoA hydratase
CDC45_RS02455	COG0183	Belongs to the thiolase family
CDC45_RS02460	COG1024	Enoyl-CoA hydratase
CDC45_RS02470	COG5265	(ABC) transporter
CDC45_RS02480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDC45_RS02490	COG0765	amino acid transport
CDC45_RS02495	COG0765	amino acid transport
CDC45_RS02500	COG1126	abc transporter atp-binding protein
CDC45_RS02505	COG0121	glutamine amidotransferase
CDC45_RS02510	COG0473	3-isopropylmalate dehydrogenase activity
CDC45_RS02520	COG0418	dihydroorotase activity
CDC45_RS02540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDC45_RS02545	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDC45_RS02560	COG0316	Belongs to the HesB IscA family
CDC45_RS02565	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDC45_RS02570	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDC45_RS02575	COG1490	D-aminoacyl-tRNA deacylase activity
CDC45_RS02590	COG2255	four-way junction helicase activity
CDC45_RS02595	COG0632	four-way junction helicase activity
CDC45_RS02605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDC45_RS02610	COG0138	bifunctional purine biosynthesis protein purh
CDC45_RS02615	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDC45_RS02630	COG4680	protein conserved in bacteria
CDC45_RS02640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC45_RS02645	COG0006	proline dipeptidase activity
CDC45_RS02655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC45_RS02675	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CDC45_RS02680	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC45_RS02685	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDC45_RS02690	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDC45_RS02695	COG0697	spore germination
CDC45_RS02700	COG0346	lactoylglutathione lyase activity
CDC45_RS02715	COG0204	Acyl-transferase
CDC45_RS02720	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CDC45_RS02725	COG0751	glycine-tRNA ligase activity
CDC45_RS02735	COG0752	glycyl-tRNA synthetase alpha subunit
CDC45_RS02740	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDC45_RS02745	COG4535	Mg2 and Co2 transporter CorC
CDC45_RS02750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDC45_RS02755	COG1702	phosphate starvation-inducible protein PhoH
CDC45_RS02760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC45_RS02815	COG0513	Belongs to the DEAD box helicase family
CDC45_RS02835	COG0745	RESPONSE REGULATOR receiver
CDC45_RS02860	COG0477	Major facilitator Superfamily
CDC45_RS02870	COG0642	Histidine kinase
CDC45_RS02880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDC45_RS02885	COG2137	regulation of response to DNA damage stimulus
CDC45_RS02895	COG0045	succinate-CoA ligase (ADP-forming) activity
CDC45_RS02905	COG0861	Integral membrane protein TerC family
CDC45_RS02915	COG4969	Belongs to the N-Me-Phe pilin family
CDC45_RS02925	COG0315	cyclic pyranopterin monophosphate synthase activity
CDC45_RS02930	COG4783	chaperone-mediated protein folding
CDC45_RS02940	COG0429	hydrolase of the alpha beta-hydrolase fold
CDC45_RS02950	COG0859	PFAM glycosyl transferase family 9
CDC45_RS02980	COG0126	phosphoglycerate kinase activity
CDC45_RS02985	COG0469	pyruvate kinase activity
CDC45_RS02995	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDC45_RS03000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDC45_RS03005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDC45_RS03010	COG0009	L-threonylcarbamoyladenylate synthase
CDC45_RS03025	COG0546	phosphoglycolate phosphatase activity
CDC45_RS03035	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC45_RS03040	COG2027	D-alanyl-D-alanine carboxypeptidase
CDC45_RS03045	COG0738	Major facilitator superfamily
CDC45_RS03110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS03120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC45_RS03120	COG3008	intermembrane lipid transfer
CDC45_RS03125	COG2995	paraquat-inducible protein a
CDC45_RS03145	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDC45_RS03150	COG0840	transmembrane signaling receptor activity
CDC45_RS03195	COG0697	spore germination
CDC45_RS03220	COG2974	May be involved in recombination
CDC45_RS03225	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
CDC45_RS03230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC45_RS03245	COG0513	Belongs to the DEAD box helicase family
CDC45_RS03265	COG2207	Transcriptional regulator
CDC45_RS03285	COG4654	Cytochrome c, class I
CDC45_RS03300	COG1064	alcohol dehydrogenase
CDC45_RS03310	COG0583	DNA-binding transcription factor activity
CDC45_RS03320	COG1309	transcriptional regulator
CDC45_RS03340	COG0443	Heat shock 70 kDa protein
CDC45_RS03350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDC45_RS03355	COG0459	protein refolding
CDC45_RS03360	COG4269	membrane
CDC45_RS03420	COG4964	Belongs to the GSP D family
CDC45_RS03465	COG1704	LemA family
CDC45_RS03475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC45_RS03480	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC45_RS03485	COG1773	rubredoxin
CDC45_RS03505	COG0840	transmembrane signaling receptor activity
CDC45_RS03510	COG0643	Histidine kinase
CDC45_RS03510	COG2198	Histidine kinase
CDC45_RS03510	COG0784	Response regulator, receiver
CDC45_RS03520	COG1187	pseudouridine synthase activity
CDC45_RS03525	COG1678	Uncharacterized ACR, COG1678
CDC45_RS03530	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDC45_RS03535	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CDC45_RS03540	COG0540	Belongs to the ATCase OTCase family
CDC45_RS03555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDC45_RS03560	COG1088	dTDP-glucose 4,6-dehydratase activity
CDC45_RS03595	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC45_RS03610	COG0859	PFAM glycosyl transferase family 9
CDC45_RS03630	COG0425	Belongs to the sulfur carrier protein TusA family
CDC45_RS03630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDC45_RS03635	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC45_RS03660	COG1968	undecaprenyl-diphosphatase activity
CDC45_RS03665	COG1902	pentaerythritol trinitrate reductase activity
CDC45_RS03670	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDC45_RS03700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDC45_RS03710	COG0436	Aminotransferase
CDC45_RS03715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC45_RS03720	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDC45_RS03735	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC45_RS03735	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC45_RS03800	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CDC45_RS03805	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC45_RS03810	COG4221	oxidoreductase activity
CDC45_RS03815	COG0824	Thioesterase
CDC45_RS03835	COG0823	Involved in the tonB-independent uptake of proteins
CDC45_RS03850	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDC45_RS03855	COG2391	methyltransferase activity
CDC45_RS03870	COG0745	RESPONSE REGULATOR receiver
CDC45_RS03875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC45_RS03880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC45_RS03895	COG2175	clavaminate synthase activity
CDC45_RS03905	COG0390	transport system, permease component
CDC45_RS03910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC45_RS03930	COG4575	ribosome binding
CDC45_RS03935	COG0450	alkyl hydroperoxide reductase
CDC45_RS03940	COG2252	PERMEase
CDC45_RS03945	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS03955	COG3483	tryptophan 2,3-dioxygenase activity
CDC45_RS03965	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC45_RS03970	COG1522	sequence-specific DNA binding
CDC45_RS03980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC45_RS03985	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC45_RS03995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC45_RS04000	COG0259	pyridoxamine-phosphate oxidase activity
CDC45_RS04025	COG2982	Protein involved in outer membrane biogenesis
CDC45_RS04030	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDC45_RS04035	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CDC45_RS04040	COG2703	oxygen carrier activity
CDC45_RS04050	COG3118	belongs to the thioredoxin family
CDC45_RS04055	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS04065	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CDC45_RS04080	COG4681	YaeQ
CDC45_RS04110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC45_RS04135	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC45_RS04140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC45_RS04165	COG0330	HflC and HflK could
CDC45_RS04180	COG0477	Major facilitator Superfamily
CDC45_RS04185	COG0235	Class ii aldolase
CDC45_RS04190	COG1942	4-Oxalocrotonate Tautomerase
CDC45_RS04205	COG0425	Belongs to the sulfur carrier protein TusA family
CDC45_RS04220	COG1280	lysine exporter protein (LysE YggA)
CDC45_RS04240	COG4305	rare lipoprotein A
CDC45_RS04255	COG0778	Nitroreductase
CDC45_RS04295	COG0653	protein targeting
CDC45_RS04365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CDC45_RS04475	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC45_RS04645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC45_RS04670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDC45_RS04675	COG1605	Chorismate mutase
CDC45_RS04675	COG0077	Prephenate dehydratase
CDC45_RS04680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC45_RS04685	COG0287	Prephenate dehydrogenase
CDC45_RS04690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDC45_RS04695	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CDC45_RS04705	COG0776	regulation of translation
CDC45_RS04715	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CDC45_RS04725	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CDC45_RS04730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC45_RS04745	COG2951	lytic endotransglycosylase activity
CDC45_RS04750	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC45_RS04755	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDC45_RS04760	COG2011	ABC-type metal ion transport system permease component
CDC45_RS04780	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS04785	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS04820	COG0228	four-way junction DNA binding
CDC45_RS04825	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDC45_RS04830	COG0336	Belongs to the RNA methyltransferase TrmD family
CDC45_RS04835	COG0335	large ribosomal subunit rRNA binding
CDC45_RS04840	COG0494	nUDIX hydrolase
CDC45_RS04845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC45_RS04855	COG1162	GTPase activity
CDC45_RS04860	COG0501	Belongs to the peptidase M48B family
CDC45_RS04865	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDC45_RS04870	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDC45_RS04875	COG3028	Belongs to the UPF0307 family
CDC45_RS04880	COG0312	modulator of DNA gyrase
CDC45_RS04890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDC45_RS04900	COG0861	Integral membrane protein TerC family
CDC45_RS04910	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC45_RS04915	COG0513	Belongs to the DEAD box helicase family
CDC45_RS04980	COG0582	viral genome integration into host DNA
CDC45_RS05015	COG0488	(ABC) transporter
CDC45_RS05025	COG0741	lytic transglycosylase activity
CDC45_RS05045	COG1620	l-lactate permease
CDC45_RS05060	COG0625	glutathione transferase activity
CDC45_RS05065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS05075	COG0697	spore germination
CDC45_RS05080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC45_RS05085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS05090	COG0326	Molecular chaperone. Has ATPase activity
CDC45_RS05130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC45_RS05160	COG0778	Nitroreductase
CDC45_RS05165	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDC45_RS05170	COG2878	Part of a membrane complex involved in electron transport
CDC45_RS05175	COG1309	transcriptional regulator
CDC45_RS05195	COG0556	nucleotide-excision repair
CDC45_RS05205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC45_RS05210	COG1609	Transcriptional regulator
CDC45_RS05215	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDC45_RS05225	COG1879	ABC-type sugar transport system periplasmic component
CDC45_RS05235	COG1104	cysteine desulfurase activity
CDC45_RS05240	COG0822	iron-sulfur transferase activity
CDC45_RS05245	COG0316	Belongs to the HesB IscA family
CDC45_RS05255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CDC45_RS05260	COG0443	Heat shock 70 kDa protein
CDC45_RS05280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDC45_RS05285	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS05295	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CDC45_RS05310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC45_RS05315	COG1322	Protein conserved in bacteria
CDC45_RS05330	COG0746	molybdenum cofactor guanylyltransferase activity
CDC45_RS05335	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDC45_RS05340	COG1530	ribonuclease E activity
CDC45_RS05350	COG0546	phosphoglycolate phosphatase activity
CDC45_RS05360	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDC45_RS05360	COG0616	signal peptide processing
CDC45_RS05370	COG0424	maF-like protein
CDC45_RS05375	COG1399	metal-binding, possibly nucleic acid-binding protein
CDC45_RS05380	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDC45_RS05385	COG0416	fatty acid biosynthetic process
CDC45_RS05390	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDC45_RS05400	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS05405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC45_RS05410	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC45_RS05435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC45_RS05445	COG0481	GTPase activity
CDC45_RS05450	COG0681	Belongs to the peptidase S26 family
CDC45_RS05460	COG0571	ribonuclease III activity
CDC45_RS05465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDC45_RS05470	COG1381	Involved in DNA repair and RecF pathway recombination
CDC45_RS05475	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDC45_RS05480	COG0736	holo-[acyl-carrier-protein] synthase activity
CDC45_RS05490	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDC45_RS05500	COG0322	excinuclease ABC activity
CDC45_RS05530	COG0745	RESPONSE REGULATOR receiver
CDC45_RS05540	COG5002	protein histidine kinase activity
CDC45_RS05550	COG0745	RESPONSE REGULATOR receiver
CDC45_RS05560	COG2186	Transcriptional regulator
CDC45_RS05570	COG2271	Major facilitator Superfamily
CDC45_RS05580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS05590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS05595	COG0625	glutathione transferase activity
CDC45_RS05635	COG2271	Major facilitator Superfamily
CDC45_RS05640	COG0583	DNA-binding transcription factor activity
CDC45_RS05650	COG0436	Aminotransferase
CDC45_RS05680	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC45_RS05680	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC45_RS05720	COG0583	DNA-binding transcription factor activity
CDC45_RS05725	COG2855	membrane
CDC45_RS05750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC45_RS05755	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDC45_RS05770	COG1136	(ABC) transporter
CDC45_RS05775	COG0084	hydrolase, TatD family'
CDC45_RS05785	COG2308	Evidence 4 Homologs of previously reported genes of
CDC45_RS05805	COG2267	carboxylic ester hydrolase activity
CDC45_RS05810	COG0504	CTP synthase activity
CDC45_RS05815	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDC45_RS05825	COG0148	phosphopyruvate hydratase activity
CDC45_RS05830	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDC45_RS05840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDC45_RS05850	COG2833	Protein of unknown function (DUF455)
CDC45_RS05855	COG2267	carboxylic ester hydrolase activity
CDC45_RS05860	COG3011	Protein conserved in bacteria
CDC45_RS05875	COG0492	ferredoxin-NADP+ reductase activity
CDC45_RS05880	COG0613	PHP domain protein
CDC45_RS05885	COG0009	L-threonylcarbamoyladenylate synthase
CDC45_RS05890	COG1994	Peptidase M50
CDC45_RS05895	COG0180	Tryptophanyl-tRNA synthetase
CDC45_RS05905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC45_RS05910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CDC45_RS05915	COG0321	lipoyl(octanoyl) transferase activity
CDC45_RS05915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CDC45_RS05925	COG2850	peptidyl-arginine hydroxylation
CDC45_RS05940	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CDC45_RS05945	COG0583	DNA-binding transcription factor activity
CDC45_RS05950	COG2814	Major facilitator Superfamily
CDC45_RS05960	COG0840	transmembrane signaling receptor activity
CDC45_RS05970	COG2258	MOSC domain
CDC45_RS05980	COG1396	sequence-specific DNA binding
CDC45_RS05985	COG0483	inositol monophosphate 1-phosphatase activity
CDC45_RS05995	COG1045	serine acetyltransferase
CDC45_RS06000	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC45_RS06005	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CDC45_RS06020	COG0215	cysteine-tRNA ligase activity
CDC45_RS06025	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CDC45_RS06030	COG0825	malonyl-CoA metabolic process
CDC45_RS06035	COG0037	tRNA processing
CDC45_RS06040	COG0527	aspartate kinase activity
CDC45_RS06055	COG4166	transmembrane transport
CDC45_RS06060	COG4174	ABC transporter (Permease)
CDC45_RS06065	COG4239	(ABC) transporter, permease
CDC45_RS06070	COG4172	Belongs to the ABC transporter superfamily
CDC45_RS06075	COG0791	NLP P60 protein
CDC45_RS06080	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDC45_RS06085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC45_RS06120	COG0534	Mate efflux family protein
CDC45_RS06130	COG0254	rRNA binding
CDC45_RS06140	COG3228	Belongs to the MtfA family
CDC45_RS06145	COG2197	response regulator
CDC45_RS06150	COG2204	response regulator
CDC45_RS06155	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDC45_RS06170	COG1074	ATP-dependent DNA helicase activity
CDC45_RS06180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CDC45_RS06185	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDC45_RS06190	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDC45_RS06205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC45_RS06210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC45_RS06220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC45_RS06225	COG1309	transcriptional regulator
CDC45_RS06230	COG1902	pentaerythritol trinitrate reductase activity
CDC45_RS06235	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS06235	COG3321	synthase
CDC45_RS06235	COG0604	alcohol dehydrogenase
CDC45_RS06240	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDC45_RS06245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC45_RS06265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDC45_RS06275	COG0105	UTP biosynthetic process
CDC45_RS06280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDC45_RS06295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDC45_RS06300	COG0124	histidyl-tRNA synthetase
CDC45_RS06305	COG2976	Protein conserved in bacteria
CDC45_RS06315	COG1160	GTP binding
CDC45_RS06320	COG1923	regulation of RNA biosynthetic process
CDC45_RS06325	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDC45_RS06330	COG0330	HflC and HflK could
CDC45_RS06335	COG0330	HflC and HflK could
CDC45_RS06345	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDC45_RS06350	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDC45_RS06355	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CDC45_RS06365	COG0557	exoribonuclease II activity
CDC45_RS06370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC45_RS06375	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CDC45_RS06380	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC45_RS06385	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDC45_RS06390	COG1953	Uracil, thiamine, allantoin
CDC45_RS06400	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CDC45_RS06410	COG3718	enzyme involved in inositol metabolism
CDC45_RS06420	COG3962	Belongs to the TPP enzyme family
CDC45_RS06425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC45_RS06435	COG1129	ABC transporter
CDC45_RS06440	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDC45_RS06445	COG1082	Xylose isomerase domain protein TIM barrel
CDC45_RS06455	COG0673	inositol 2-dehydrogenase activity
CDC45_RS06465	COG0673	inositol 2-dehydrogenase activity
CDC45_RS06470	COG1737	Transcriptional regulator
CDC45_RS06475	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC45_RS06475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDC45_RS06480	COG1643	Atp-dependent helicase
CDC45_RS06505	COG1058	Belongs to the CinA family
CDC45_RS06505	COG1546	Belongs to the CinA family
CDC45_RS06515	COG0174	glutamine synthetase
CDC45_RS06530	COG2204	response regulator
CDC45_RS06545	COG1653	transport
CDC45_RS06550	COG1175	transmembrane transport
CDC45_RS06560	COG3842	ATPase activity
CDC45_RS06565	COG0584	glycerophosphoryl diester phosphodiesterase
CDC45_RS06570	COG0567	Dehydrogenase, E1 component
CDC45_RS06575	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC45_RS06580	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC45_RS06585	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CDC45_RS06595	COG2217	Heavy metal translocating P-type atpase
CDC45_RS06605	COG3278	Belongs to the heme-copper respiratory oxidase family
CDC45_RS06640	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC45_RS06650	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDC45_RS06655	COG1187	pseudouridine synthase activity
CDC45_RS06660	COG0779	Required for maturation of 30S ribosomal subunits
CDC45_RS06665	COG2251	uridine kinase activity
CDC45_RS06665	COG0195	Participates in both transcription termination and antitermination
CDC45_RS06670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDC45_RS06675	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDC45_RS06680	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDC45_RS06685	COG2814	Major facilitator Superfamily
CDC45_RS06690	COG1566	PFAM secretion protein HlyD family protein
CDC45_RS06705	COG1217	gtp-binding protein TYPA
CDC45_RS06715	COG1024	Enoyl-CoA hydratase
CDC45_RS06740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC45_RS06755	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDC45_RS06770	COG0360	Binds together with S18 to 16S ribosomal RNA
CDC45_RS06780	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDC45_RS06785	COG0359	binds to the 23S rRNA
CDC45_RS06790	COG0305	Participates in initiation and elongation during chromosome replication
CDC45_RS06800	COG0306	phosphate transporter
CDC45_RS06805	COG0791	NLP P60 protein
CDC45_RS06815	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDC45_RS06820	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDC45_RS06830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC45_RS06830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC45_RS06845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC45_RS06850	COG2076	Multidrug Resistance protein
CDC45_RS06855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDC45_RS06865	COG0436	Aminotransferase
CDC45_RS06880	COG1573	uracil-dna glycosylase
CDC45_RS06885	COG0303	'Molybdopterin
CDC45_RS06890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CDC45_RS06895	COG0314	molybdopterin synthase activity
CDC45_RS06900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDC45_RS06910	COG0542	response to heat
CDC45_RS06915	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDC45_RS06920	COG0431	NADPH-dependent FMN reductase
CDC45_RS06925	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC45_RS06930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC45_RS06935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC45_RS06940	COG1116	anion transmembrane transporter activity
CDC45_RS06965	COG4208	sulfate ABC transporter
CDC45_RS06970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC45_RS06975	COG0583	DNA-binding transcription factor activity
CDC45_RS06990	COG3275	phosphorelay sensor kinase activity
CDC45_RS07005	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC45_RS07025	COG2224	Isocitrate lyase
CDC45_RS07035	COG0583	DNA-binding transcription factor activity
CDC45_RS07050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDC45_RS07060	COG2814	Major facilitator Superfamily
CDC45_RS07070	COG1214	PFAM Peptidase M22, glycoprotease
CDC45_RS07075	COG0456	acetyltransferase
CDC45_RS07080	COG1573	uracil-dna glycosylase
CDC45_RS07085	COG0477	Major facilitator Superfamily
CDC45_RS07090	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDC45_RS07100	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC45_RS07105	COG1683	Conserved Protein
CDC45_RS07110	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC45_RS07115	COG0488	(ABC) transporter
CDC45_RS07130	COG4172	Belongs to the ABC transporter superfamily
CDC45_RS07135	COG0747	negative chemotaxis
CDC45_RS07140	COG0601	transmembrane transport
CDC45_RS07145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC45_RS07170	COG0302	gtp cyclohydrolase
CDC45_RS07175	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC45_RS07185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC45_RS07190	COG1393	Belongs to the ArsC family
CDC45_RS07200	COG2171	N-acyltransferase activity
CDC45_RS07215	COG0596	Alpha beta hydrolase
CDC45_RS07230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDC45_RS07235	COG0242	peptide deformylase activity
CDC45_RS07245	COG1187	pseudouridine synthase activity
CDC45_RS07250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDC45_RS07255	COG0024	Methionine aminopeptidase
CDC45_RS07260	COG0052	Belongs to the universal ribosomal protein uS2 family
CDC45_RS07265	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDC45_RS07270	COG0528	UMP kinase activity
CDC45_RS07275	COG0233	cytoplasmic translational termination
CDC45_RS07280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDC45_RS07285	COG0575	Belongs to the CDS family
CDC45_RS07290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDC45_RS07295	COG0750	zinc metalloprotease
CDC45_RS07310	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC45_RS07315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC45_RS07320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC45_RS07325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC45_RS07330	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDC45_RS07335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC45_RS07340	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CDC45_RS07355	COG0330	HflC and HflK could
CDC45_RS07360	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDC45_RS07365	COG2867	negative regulation of translational initiation
CDC45_RS07370	COG2914	Belongs to the UPF0125 (RnfH) family
CDC45_RS07380	COG0697	spore germination
CDC45_RS07395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC45_RS07395	COG0519	Catalyzes the synthesis of GMP from XMP
CDC45_RS07455	COG0583	DNA-binding transcription factor activity
CDC45_RS07460	COG3485	protocatechuate 3,4-dioxygenase
CDC45_RS07465	COG3485	protocatechuate 3,4-dioxygenase
CDC45_RS07485	COG3550	peptidyl-serine autophosphorylation
CDC45_RS07505	COG0602	queuosine metabolic process
CDC45_RS07510	COG0720	synthase
CDC45_RS07520	COG1619	proteins homologs of microcin C7 resistance protein MccF
CDC45_RS07525	COG0488	(ABC) transporter
CDC45_RS07550	COG3387	PFAM Glycoside hydrolase 15-related
CDC45_RS07560	COG0840	transmembrane signaling receptor activity
CDC45_RS07575	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDC45_RS07610	COG3045	CreA protein
CDC45_RS07645	COG0156	8-amino-7-oxononanoate synthase activity
CDC45_RS07650	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDC45_RS07715	COG0582	viral genome integration into host DNA
CDC45_RS07745	COG0656	L-ascorbic acid biosynthetic process
CDC45_RS07750	COG2304	oxidoreductase activity
CDC45_RS07765	COG0589	response to stress
CDC45_RS07800	COG0328	RNA-DNA hybrid ribonuclease activity
CDC45_RS07805	COG2226	methyltransferase
CDC45_RS07810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC45_RS07815	COG0741	lytic transglycosylase activity
CDC45_RS07815	COG1388	LysM domain
CDC45_RS07820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC45_RS07825	COG0505	Belongs to the CarA family
CDC45_RS07835	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDC45_RS07840	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC45_RS07850	COG1534	Rna-binding protein
CDC45_RS07855	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDC45_RS07860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC45_RS07865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDC45_RS07870	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC45_RS07875	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC45_RS07880	COG0573	inorganic phosphate transmembrane transporter activity
CDC45_RS07885	COG0581	inorganic phosphate transmembrane transporter activity
CDC45_RS07890	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC45_RS07900	COG0745	RESPONSE REGULATOR receiver
CDC45_RS07910	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CDC45_RS07915	COG0248	Ppx GppA phosphatase
CDC45_RS07940	COG0730	response to heat
CDC45_RS07950	COG0640	Transcriptional regulator
CDC45_RS07960	COG5001	Diguanylate cyclase
CDC45_RS07960	COG3300	MHYT domain
CDC45_RS07970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC45_RS08000	COG2963	transposase activity
CDC45_RS08045	COG0277	FAD linked oxidase domain protein
CDC45_RS08060	COG1295	ribonuclease BN
CDC45_RS08085	COG0477	Major facilitator Superfamily
CDC45_RS08090	COG0545	Peptidyl-prolyl cis-trans isomerase
CDC45_RS08095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDC45_RS08105	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS08110	COG4566	intracellular signal transduction
CDC45_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS08135	COG0251	oxidation-reduction process
CDC45_RS08140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC45_RS08150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDC45_RS08155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDC45_RS08160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDC45_RS08165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDC45_RS08170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDC45_RS08175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC45_RS08175	COG0072	phenylalanine-tRNA ligase activity
CDC45_RS08180	COG0776	regulation of translation
CDC45_RS08205	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDC45_RS08210	COG0531	amino acid
CDC45_RS08230	COG1846	Transcriptional regulator
CDC45_RS08240	COG0402	S-adenosylhomocysteine deaminase activity
CDC45_RS08245	COG0339	signal peptide processing
CDC45_RS08250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDC45_RS08255	COG4566	intracellular signal transduction
CDC45_RS08270	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CDC45_RS08275	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC45_RS08285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC45_RS08300	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC45_RS08325	COG1414	Transcriptional regulator
CDC45_RS08350	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CDC45_RS08355	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDC45_RS08375	COG0167	dihydroorotate dehydrogenase activity
CDC45_RS08385	COG3158	transport of potassium into the cell
CDC45_RS08395	COG2183	response to ionizing radiation
CDC45_RS08410	COG1199	ATP-dependent helicase activity
CDC45_RS08420	COG0564	pseudouridine synthase activity
CDC45_RS08435	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDC45_RS08440	COG0183	Belongs to the thiolase family
CDC45_RS08445	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS08455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC45_RS08460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC45_RS08465	COG0183	Belongs to the thiolase family
CDC45_RS08480	COG0560	Phosphoserine phosphatase
CDC45_RS08490	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDC45_RS08495	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDC45_RS08500	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDC45_RS08505	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC45_RS08510	COG0450	alkyl hydroperoxide reductase
CDC45_RS08540	COG1562	ergosterol biosynthetic process
CDC45_RS08545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS08690	COG4626	Terminase
CDC45_RS08690	COG1802	Transcriptional regulator
CDC45_RS08745	COG1196	nuclear chromosome segregation
CDC45_RS08825	COG3039	Transposase
CDC45_RS08835	COG1652	LysM domain
CDC45_RS08845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS08845	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC45_RS08850	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDC45_RS08855	COG0740	serine-type endopeptidase activity
CDC45_RS08860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDC45_RS08865	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDC45_RS08870	COG0776	regulation of translation
CDC45_RS08885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC45_RS08900	COG4181	ATPase activity
CDC45_RS08905	COG0166	Belongs to the GPI family
CDC45_RS08910	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDC45_RS08920	COG0047	phosphoribosylformylglycinamidine synthase activity
CDC45_RS08920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDC45_RS08940	COG0535	radical SAM domain protein
CDC45_RS08945	COG0583	DNA-binding transcription factor activity
CDC45_RS08950	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS08960	COG1176	ABC-type spermidine putrescine transport system, permease component I
CDC45_RS08970	COG3842	ATPase activity
CDC45_RS08975	COG0642	Histidine kinase
CDC45_RS08985	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS08990	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CDC45_RS09015	COG1126	abc transporter atp-binding protein
CDC45_RS09020	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC45_RS09030	COG2917	probably involved in intracellular septation
CDC45_RS09035	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC45_RS09040	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDC45_RS09045	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS09055	COG0559	Belongs to the binding-protein-dependent transport system permease family
CDC45_RS09085	COG0833	amino acid
CDC45_RS09090	COG0833	amino acid
CDC45_RS09100	COG1335	isochorismatase
CDC45_RS09105	COG0183	Belongs to the thiolase family
CDC45_RS09110	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS09115	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS09130	COG2130	NADP-dependent
CDC45_RS09150	COG0596	Alpha beta hydrolase
CDC45_RS09190	COG2831	hemolysin activation secretion protein
CDC45_RS09210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDC45_RS09215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDC45_RS09220	COG0470	DNA polymerase III
CDC45_RS09230	COG0084	hydrolase, TatD family'
CDC45_RS09240	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC45_RS09245	COG1609	Transcriptional regulator
CDC45_RS09250	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC45_RS09260	COG4208	sulfate ABC transporter
CDC45_RS09265	COG3842	ATPase activity
CDC45_RS09270	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC45_RS09275	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDC45_RS09310	COG0038	chloride channel
CDC45_RS09315	COG2226	methyltransferase
CDC45_RS09325	COG3433	isochorismatase activity
CDC45_RS09325	COG2226	methyltransferase
CDC45_RS09325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC45_RS09330	COG4771	TonB-dependent receptor
CDC45_RS09335	COG2375	cellular response to nickel ion
CDC45_RS09335	COG1132	(ABC) transporter
CDC45_RS09350	COG2226	methyltransferase
CDC45_RS09350	COG3433	isochorismatase activity
CDC45_RS09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC45_RS09365	COG2201	protein-glutamate methylesterase activity
CDC45_RS09370	COG0456	acetyltransferase
CDC45_RS09415	COG0179	Fumarylacetoacetate (FAA) hydrolase
CDC45_RS09465	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC45_RS09495	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
CDC45_RS09520	COG2801	Transposase and inactivated derivatives
CDC45_RS09570	COG2814	Major facilitator Superfamily
CDC45_RS09595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS09605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC45_RS09665	COG0582	viral genome integration into host DNA
CDC45_RS09675	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDC45_RS09720	COG2072	flavoprotein involved in K transport
CDC45_RS09725	COG0601	transmembrane transport
CDC45_RS09730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC45_RS09745	COG0747	negative chemotaxis
CDC45_RS09785	COG0840	transmembrane signaling receptor activity
CDC45_RS09790	COG2197	response regulator
CDC45_RS10000	COG4695	Portal protein
CDC45_RS10035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDC45_RS10040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC45_RS10045	COG0697	spore germination
CDC45_RS10060	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDC45_RS10065	COG1301	dicarboxylic acid transport
CDC45_RS10110	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CDC45_RS10140	COG1131	(ABC) transporter
CDC45_RS10145	COG0842	Transport permease protein
CDC45_RS10165	COG0285	dihydrofolate synthase activity
CDC45_RS10170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDC45_RS10175	COG0159	tryptophan synthase activity
CDC45_RS10185	COG0133	tryptophan synthase activity
CDC45_RS10190	COG0135	phosphoribosylanthranilate isomerase activity
CDC45_RS10195	COG0101	tRNA pseudouridine synthase activity
CDC45_RS10210	COG0473	3-isopropylmalate dehydrogenase activity
CDC45_RS10215	COG0066	3-isopropylmalate dehydratase activity
CDC45_RS10220	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDC45_RS10225	COG0372	Belongs to the citrate synthase family
CDC45_RS10230	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDC45_RS10235	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDC45_RS10240	COG1053	succinate dehydrogenase
CDC45_RS10245	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CDC45_RS10255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC45_RS10260	COG0039	L-malate dehydrogenase activity
CDC45_RS10285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CDC45_RS10300	COG0747	negative chemotaxis
CDC45_RS10310	COG2866	Carboxypeptidase
CDC45_RS10315	COG3022	response to hydroperoxide
CDC45_RS10325	COG0436	Aminotransferase
CDC45_RS10330	COG0625	glutathione transferase activity
CDC45_RS10335	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC45_RS10340	COG1024	Enoyl-CoA hydratase
CDC45_RS10370	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS10375	COG0625	glutathione transferase activity
CDC45_RS10400	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDC45_RS10405	COG0830	nickel cation binding
CDC45_RS10410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CDC45_RS10415	COG0804	urea catabolic process
CDC45_RS10420	COG0832	Belongs to the urease beta subunit family
CDC45_RS10430	COG0831	urea catabolic process
CDC45_RS10435	COG0829	nickel cation binding
CDC45_RS10470	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS10470	COG2030	dehydratase
CDC45_RS10475	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS10480	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS10500	COG1007	ATP synthesis coupled electron transport
CDC45_RS10515	COG0713	ATP synthesis coupled electron transport
CDC45_RS10525	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC45_RS10530	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDC45_RS10535	COG1034	ATP synthesis coupled electron transport
CDC45_RS10550	COG0649	NAD binding
CDC45_RS10555	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC45_RS10560	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC45_RS10565	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC45_RS10575	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CDC45_RS10580	COG0149	triose-phosphate isomerase activity
CDC45_RS10595	COG1185	polyribonucleotide nucleotidyltransferase activity
CDC45_RS10600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDC45_RS10615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC45_RS10620	COG1183	phosphatidylcholine synthase activity
CDC45_RS10625	COG0688	phosphatidylethanolamine metabolic process
CDC45_RS10630	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDC45_RS10640	COG0028	Belongs to the TPP enzyme family
CDC45_RS10675	COG0438	transferase activity, transferring glycosyl groups
CDC45_RS10685	COG1309	transcriptional regulator
CDC45_RS10710	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDC45_RS10735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CDC45_RS10745	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDC45_RS10750	COG0402	S-adenosylhomocysteine deaminase activity
CDC45_RS10755	COG2119	membrane
CDC45_RS10775	COG2186	Transcriptional regulator
CDC45_RS10785	COG0765	amino acid transport
CDC45_RS10790	COG0765	amino acid transport
CDC45_RS10795	COG1126	abc transporter atp-binding protein
CDC45_RS10805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS10815	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS10820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC45_RS10825	COG2271	Major facilitator Superfamily
CDC45_RS10830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS10845	COG2351	hydroxyisourate hydrolase activity
CDC45_RS10855	COG2233	PERMEase
CDC45_RS10870	COG3648	Uricase
CDC45_RS10870	COG3195	allantoin biosynthetic process
CDC45_RS10880	COG0280	phosphate acetyltransferase
CDC45_RS10880	COG0281	malic enzyme
CDC45_RS10890	COG0308	aminopeptidase N
CDC45_RS10895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDC45_RS10905	COG2390	Transcriptional regulator
CDC45_RS10910	COG1070	Carbohydrate kinase
CDC45_RS10915	COG0246	Mannitol dehydrogenase
CDC45_RS10940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS10945	COG0166	Belongs to the GPI family
CDC45_RS10945	COG0166	Belongs to the GPI family
CDC45_RS10950	COG1733	regulation of RNA biosynthetic process
CDC45_RS10960	COG3842	ATPase activity
CDC45_RS10965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC45_RS10990	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC45_RS11000	COG1652	LysM domain
CDC45_RS11030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC45_RS11035	COG1758	RNA polymerase activity
CDC45_RS11040	COG0194	GDP metabolic process
CDC45_RS11045	COG1561	YicC-like family, N-terminal region
CDC45_RS11050	COG0515	serine threonine protein kinase
CDC45_RS11050	COG3064	Membrane
CDC45_RS11050	COG4991	sh3 domain protein
CDC45_RS11060	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDC45_RS11065	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDC45_RS11070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC45_RS11080	COG1234	tRNA 3'-trailer cleavage
CDC45_RS11095	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC45_RS11100	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CDC45_RS11115	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC45_RS11120	COG1984	allophanate hydrolase subunit 2
CDC45_RS11125	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC45_RS11130	COG2814	Major facilitator Superfamily
CDC45_RS11135	COG3845	ABC transporter
CDC45_RS11140	COG4603	Belongs to the binding-protein-dependent transport system permease family
CDC45_RS11195	COG1803	Methylglyoxal synthase
CDC45_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS11205	COG0697	spore germination
CDC45_RS11210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CDC45_RS11215	COG0433	COG0433 Predicted ATPase
CDC45_RS11220	COG0217	transcriptional regulatory protein
CDC45_RS11225	COG0151	Belongs to the GarS family
CDC45_RS11230	COG0408	coproporphyrinogen oxidase activity
CDC45_RS11240	COG0799	negative regulation of ribosome biogenesis
CDC45_RS11245	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDC45_RS11250	COG0424	maF-like protein
CDC45_RS11255	COG1530	ribonuclease E activity
CDC45_RS11270	COG1132	(ABC) transporter
CDC45_RS11300	COG1054	Belongs to the UPF0176 family
CDC45_RS11310	COG1741	Belongs to the pirin family
CDC45_RS11315	COG0583	DNA-binding transcription factor activity
CDC45_RS11320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC45_RS11325	COG0513	Belongs to the DEAD box helicase family
CDC45_RS11330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC45_RS11330	COG0426	domain, Protein
CDC45_RS11340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC45_RS11360	COG1610	YqeY-like protein
CDC45_RS11365	COG2081	HI0933 family
CDC45_RS11370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDC45_RS11375	COG1469	GTP cyclohydrolase I activity
CDC45_RS11380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDC45_RS11385	COG0142	geranyltranstransferase activity
CDC45_RS11390	COG1722	exodeoxyribonuclease VII activity
CDC45_RS11415	COG0412	Dienelactone hydrolase
CDC45_RS11420	COG1252	NADH dehydrogenase
CDC45_RS11425	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC45_RS11425	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC45_RS11430	COG1611	Belongs to the LOG family
CDC45_RS11440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDC45_RS11450	COG0210	DNA helicase
CDC45_RS11455	COG0525	valine-tRNA ligase activity
CDC45_RS11470	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC45_RS11480	COG2342	PFAM TM1410 hypothetical-related protein
CDC45_RS11495	COG0683	leucine binding
CDC45_RS11505	COG0411	ABC transporter
CDC45_RS11520	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC45_RS11525	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC45_RS11540	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDC45_RS11550	COG1414	Transcriptional regulator
CDC45_RS11560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC45_RS11565	COG0765	amino acid transport
CDC45_RS11570	COG0765	amino acid transport
CDC45_RS11585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS11650	COG1253	flavin adenine dinucleotide binding
CDC45_RS11700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC45_RS11770	COG2165	general secretion pathway protein
CDC45_RS11825	COG2197	response regulator
CDC45_RS11840	COG2814	Major facilitator Superfamily
CDC45_RS11850	COG1522	sequence-specific DNA binding
CDC45_RS11860	COG1522	sequence-specific DNA binding
CDC45_RS11865	COG4221	oxidoreductase activity
CDC45_RS11875	COG2814	Major facilitator Superfamily
CDC45_RS11885	COG1846	Transcriptional regulator
CDC45_RS11900	COG0583	DNA-binding transcription factor activity
CDC45_RS11910	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDC45_RS11950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDC45_RS11955	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDC45_RS11965	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDC45_RS11970	COG1674	ftsk spoiiie
CDC45_RS11975	COG0492	ferredoxin-NADP+ reductase activity
CDC45_RS12015	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDC45_RS12030	COG2271	Major facilitator Superfamily
CDC45_RS12055	COG0181	hydroxymethylbilane synthase activity
CDC45_RS12060	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDC45_RS12085	COG0165	Argininosuccinate lyase
CDC45_RS12100	COG0717	Belongs to the dCTP deaminase family
CDC45_RS12105	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC45_RS12110	COG2032	superoxide dismutase activity
CDC45_RS12130	COG0437	4 iron, 4 sulfur cluster binding
CDC45_RS12135	COG0243	molybdopterin cofactor binding
CDC45_RS12135	COG3383	formate dehydrogenase (NAD+) activity
CDC45_RS12165	COG0489	protein tyrosine kinase activity
CDC45_RS12170	COG2885	chlorophyll binding
CDC45_RS12170	COG3047	cAMP biosynthetic process
CDC45_RS12175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC45_RS12175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC45_RS12185	COG2911	Protein conserved in bacteria
CDC45_RS12200	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDC45_RS12205	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDC45_RS12220	COG1492	cobalamin metabolic process
CDC45_RS12230	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC45_RS12240	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDC45_RS12250	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CDC45_RS12255	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDC45_RS12260	COG1120	ATPase activity
CDC45_RS12270	COG4206	TonB-dependent receptor
CDC45_RS12315	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDC45_RS12320	COG0583	DNA-binding transcription factor activity
CDC45_RS12325	COG0129	dihydroxy-acid dehydratase activity
CDC45_RS12340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDC45_RS12370	COG2895	sulfate adenylyltransferase (ATP) activity
CDC45_RS12380	COG0175	sulfate reduction
CDC45_RS12390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC45_RS12400	COG0583	DNA-binding transcription factor activity
CDC45_RS12410	COG2084	Dehydrogenase
CDC45_RS12445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC45_RS12480	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDC45_RS12485	COG1047	Peptidyl-prolyl cis-trans
CDC45_RS12490	COG2003	Belongs to the UPF0758 family
CDC45_RS12495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDC45_RS12500	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDC45_RS12505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC45_RS12515	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDC45_RS12525	COG1511	domain protein
CDC45_RS12525	COG3264	Mechanosensitive ion channel
CDC45_RS12535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC45_RS12535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC45_RS12540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDC45_RS12545	COG2197	response regulator
CDC45_RS12550	COG5002	protein histidine kinase activity
CDC45_RS12550	COG0784	Response regulator, receiver
CDC45_RS12555	COG0196	riboflavin kinase activity
CDC45_RS12560	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDC45_RS12565	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDC45_RS12575	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDC45_RS12580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC45_RS12585	COG0756	dUTP diphosphatase activity
CDC45_RS12590	COG0542	response to heat
CDC45_RS12595	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDC45_RS12600	COG1278	Cold shock
CDC45_RS12710	COG0582	viral genome integration into host DNA
CDC45_RS12730	COG1858	cytochrome C peroxidase
CDC45_RS12750	COG0583	DNA-binding transcription factor activity
CDC45_RS12755	COG0583	DNA-binding transcription factor activity
CDC45_RS12765	COG2259	Doxx family
CDC45_RS12780	COG2321	neutral zinc metallopeptidase
CDC45_RS12785	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS12820	COG1473	amidohydrolase
CDC45_RS12855	COG2610	gluconate transmembrane transporter activity
CDC45_RS12900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDC45_RS12905	COG1570	exodeoxyribonuclease VII activity
CDC45_RS12910	COG0811	peptide transport
CDC45_RS12920	COG1663	tetraacyldisaccharide 4'-kinase activity
CDC45_RS12925	COG2835	tetraacyldisaccharide 4'-kinase activity
CDC45_RS12930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CDC45_RS12935	COG0563	adenylate kinase activity
CDC45_RS12955	COG0583	DNA-binding transcription factor activity
CDC45_RS12965	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDC45_RS12970	COG0802	atpase or kinase
CDC45_RS12975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDC45_RS12990	COG4974	Belongs to the 'phage' integrase family
CDC45_RS13000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDC45_RS13005	COG2366	antibiotic biosynthetic process
CDC45_RS13015	COG1666	GTP binding
CDC45_RS13020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDC45_RS13030	COG3123	guanosine phosphorylase activity
CDC45_RS13035	COG0137	argininosuccinate synthase activity
CDC45_RS13040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDC45_RS13050	COG0268	Binds directly to 16S ribosomal RNA
CDC45_RS13055	COG0728	peptidoglycan biosynthetic process
CDC45_RS13065	COG0586	Pfam SNARE associated Golgi protein
CDC45_RS13080	COG3008	intermembrane lipid transfer
CDC45_RS13085	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDC45_RS13090	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC45_RS13095	COG0456	acetyltransferase
CDC45_RS13100	COG2169	Transcriptional regulator
CDC45_RS13100	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC45_RS13120	COG2169	Transcriptional regulator
CDC45_RS13120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC45_RS13160	COG3846	protein secretion by the type IV secretion system
CDC45_RS13175	COG3451	type IV secretory pathway VirB4
CDC45_RS13185	COG3838	Conjugal transfer protein Trbc
CDC45_RS13190	COG4962	Type ii secretion system protein e
CDC45_RS13210	COG0583	DNA-binding transcription factor activity
CDC45_RS13225	COG2207	Transcriptional regulator
CDC45_RS13230	COG2315	Protein conserved in bacteria
CDC45_RS13235	COG2272	Belongs to the type-B carboxylesterase lipase family
CDC45_RS13240	COG0625	glutathione transferase activity
CDC45_RS13250	COG1335	isochorismatase
CDC45_RS13255	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS13260	COG2207	Transcriptional regulator
CDC45_RS13265	COG1201	RNA secondary structure unwinding
CDC45_RS13285	COG4959	Type IV secretory pathway protease TraF
CDC45_RS13300	COG1192	Involved in chromosome partitioning
CDC45_RS13345	COG5489	Protein of unknown function (DUF736)
CDC45_RS13390	COG2003	Belongs to the UPF0758 family
CDC45_RS13395	COG4804	nuclease activity
CDC45_RS13405	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDC45_RS13410	COG0628	permease
CDC45_RS13415	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC45_RS13430	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDC45_RS13440	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDC45_RS13445	COG4662	Binding-protein-dependent transport system inner membrane component
CDC45_RS13450	COG1122	ATPase activity
CDC45_RS13455	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDC45_RS13455	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC45_RS13460	COG0484	heat shock protein binding
CDC45_RS13465	COG0443	Heat shock 70 kDa protein
CDC45_RS13470	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC45_RS13480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDC45_RS13500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC45_RS13505	COG1228	amidohydrolase
CDC45_RS13510	COG0010	Belongs to the arginase family
CDC45_RS13515	COG2986	histidine ammonia-lyase
CDC45_RS13520	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CDC45_RS13530	COG1420	regulation of RNA biosynthetic process
CDC45_RS13535	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDC45_RS13540	COG0497	DNA recombination
CDC45_RS13550	COG1404	Belongs to the peptidase S8 family
CDC45_RS13565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDC45_RS13575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDC45_RS13580	COG0312	modulator of DNA gyrase
CDC45_RS13585	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC45_RS13595	COG0668	transmembrane transport
CDC45_RS13600	COG2096	Adenosyltransferase
CDC45_RS13605	COG0277	FAD linked oxidase domain protein
CDC45_RS13610	COG0583	DNA-binding transcription factor activity
CDC45_RS13615	COG0277	FAD linked oxidase domain protein
CDC45_RS13620	COG0277	FAD linked oxidase domain protein
CDC45_RS13625	COG0247	lactate metabolic process
CDC45_RS13630	COG1380	Effector of murein hydrolase LrgA
CDC45_RS13635	COG1346	cytolysis
CDC45_RS13655	COG0386	Belongs to the glutathione peroxidase family
CDC45_RS13715	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC45_RS13720	COG0783	Belongs to the Dps family
CDC45_RS13810	COG1278	Cold shock
CDC45_RS13860	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDC45_RS13865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDC45_RS13870	COG0343	queuine tRNA-ribosyltransferase activity
CDC45_RS13875	COG1862	Preprotein translocase
CDC45_RS13880	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC45_RS13885	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC45_RS13890	COG2353	YceI-like domain
CDC45_RS13895	COG2353	YceI-like domain
CDC45_RS13900	COG3038	cytochrome b561
CDC45_RS13910	COG0625	glutathione transferase activity
CDC45_RS13915	COG0069	glutamate synthase activity
CDC45_RS13920	COG0482	sulfurtransferase activity
CDC45_RS13960	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CDC45_RS13985	COG4191	Histidine kinase
CDC45_RS13990	COG4191	Histidine kinase
CDC45_RS13995	COG2204	response regulator
CDC45_RS14005	COG1981	membrane
CDC45_RS14010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDC45_RS14015	COG1466	dna polymerase III delta subunit
CDC45_RS14025	COG0495	leucyl-tRNA aminoacylation
CDC45_RS14030	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDC45_RS14035	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDC45_RS14040	COG0735	belongs to the Fur family
CDC45_RS14045	COG0583	DNA-binding transcription factor activity
CDC45_RS14050	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDC45_RS14055	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDC45_RS14060	COG4948	Mandelate Racemase Muconate Lactonizing
CDC45_RS14065	COG0800	Aldolase
CDC45_RS14070	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS14090	COG1129	ABC transporter
CDC45_RS14105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS14110	COG0583	DNA-binding transcription factor activity
CDC45_RS14120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDC45_RS14140	COG0280	phosphate acetyltransferase
CDC45_RS14140	COG0281	malic enzyme
CDC45_RS14150	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDC45_RS14155	COG1058	Belongs to the CinA family
CDC45_RS14155	COG1546	Belongs to the CinA family
CDC45_RS14165	COG0284	orotidine-5'-phosphate decarboxylase activity
CDC45_RS14180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDC45_RS14185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC45_RS14195	COG0557	exoribonuclease II activity
CDC45_RS14200	COG3161	chorismate lyase activity
CDC45_RS14205	COG3150	esterase
CDC45_RS14210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC45_RS14220	COG3118	belongs to the thioredoxin family
CDC45_RS14225	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC45_RS14230	COG0511	ligase activity, forming carbon-carbon bonds
CDC45_RS14240	COG2264	protein methyltransferase activity
CDC45_RS14250	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CDC45_RS14255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC45_RS14300	COG0840	transmembrane signaling receptor activity
CDC45_RS14310	COG1522	sequence-specific DNA binding
CDC45_RS14335	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDC45_RS14360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDC45_RS14365	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CDC45_RS14370	COG2095	MarC family integral membrane protein
CDC45_RS14380	COG0741	lytic transglycosylase activity
CDC45_RS14385	COG0442	prolyl-tRNA aminoacylation
CDC45_RS14390	COG0494	nUDIX hydrolase
CDC45_RS14400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDC45_RS14405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDC45_RS14410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDC45_RS14415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDC45_RS14420	COG0142	geranyltranstransferase activity
CDC45_RS14430	COG4536	flavin adenine dinucleotide binding
CDC45_RS14440	COG1459	type II secretion system
CDC45_RS14450	COG0237	dephospho-CoA kinase activity
CDC45_RS14455	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CDC45_RS14460	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDC45_RS14465	COG0494	nUDIX hydrolase
CDC45_RS14475	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDC45_RS14480	COG0653	protein targeting
CDC45_RS14485	COG0739	heme binding
CDC45_RS14495	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDC45_RS14500	COG0678	peroxiredoxin activity
CDC45_RS14515	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDC45_RS14520	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC45_RS14525	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC45_RS14530	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDC45_RS14540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDC45_RS14545	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC45_RS14550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDC45_RS14555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDC45_RS14570	COG0275	rRNA processing
CDC45_RS14575	COG2001	Belongs to the MraZ family
CDC45_RS14580	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CDC45_RS14585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS14590	COG0477	Major facilitator Superfamily
CDC45_RS14595	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS14605	COG0243	molybdopterin cofactor binding
CDC45_RS14610	COG1609	Transcriptional regulator
CDC45_RS14615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC45_RS14615	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC45_RS14620	COG1105	Belongs to the carbohydrate kinase PfkB family
CDC45_RS14625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC45_RS14625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC45_RS14635	COG4608	Belongs to the ABC transporter superfamily
CDC45_RS14640	COG0444	Belongs to the ABC transporter superfamily
CDC45_RS14645	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC45_RS14650	COG0601	transmembrane transport
CDC45_RS14655	COG0747	negative chemotaxis
CDC45_RS14660	COG1473	amidohydrolase
CDC45_RS14690	COG1024	Enoyl-CoA hydratase
CDC45_RS14695	COG1024	Enoyl-CoA hydratase
CDC45_RS14700	COG2050	protein possibly involved in aromatic compounds catabolism
CDC45_RS14720	COG2967	ApaG domain
CDC45_RS14725	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDC45_RS14730	COG0546	phosphoglycolate phosphatase activity
CDC45_RS14740	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC45_RS14750	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC45_RS14755	COG0134	indole-3-glycerol-phosphate synthase activity
CDC45_RS14765	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDC45_RS14780	COG1289	transmembrane transporter activity
CDC45_RS14790	COG0604	alcohol dehydrogenase
CDC45_RS14800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC45_RS14830	COG0012	GTP binding
CDC45_RS14840	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDC45_RS14845	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDC45_RS14855	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC45_RS14860	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDC45_RS14875	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC45_RS14880	COG3416	Protein conserved in bacteria
CDC45_RS14880	COG2943	transferase activity, transferring hexosyl groups
CDC45_RS14900	COG0488	(ABC) transporter
CDC45_RS14905	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CDC45_RS14920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC45_RS14930	COG3712	iron ion homeostasis
CDC45_RS14935	COG4774	siderophore transport
CDC45_RS14940	COG0405	Gamma-glutamyltransferase
CDC45_RS14965	COG2969	positive regulation of protein catabolic process
CDC45_RS14970	COG0625	glutathione transferase activity
CDC45_RS14975	COG2857	Cytochrome c1
CDC45_RS14980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDC45_RS14985	COG0723	plastoquinol--plastocyanin reductase activity
CDC45_RS14990	COG1970	mechanosensitive ion channel activity
CDC45_RS14995	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDC45_RS15000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC45_RS15005	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS15020	COG0642	Histidine kinase
CDC45_RS15025	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC45_RS15035	COG3842	ATPase activity
CDC45_RS15040	COG0805	protein transport
CDC45_RS15045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC45_RS15050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC45_RS15060	COG0140	phosphoribosyl-ATP diphosphatase activity
CDC45_RS15065	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDC45_RS15070	COG0107	imidazoleglycerol-phosphate synthase activity
CDC45_RS15075	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDC45_RS15080	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDC45_RS15085	COG2095	MarC family integral membrane protein
CDC45_RS15090	COG0131	Imidazoleglycerol-phosphate dehydratase
CDC45_RS15095	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC45_RS15100	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDC45_RS15105	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDC45_RS15110	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDC45_RS15120	COG0842	Transport permease protein
CDC45_RS15125	COG1131	(ABC) transporter
CDC45_RS15145	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC45_RS15150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC45_RS15155	COG1127	ABC transporter
CDC45_RS15170	COG0067	glutamate synthase
CDC45_RS15170	COG0070	glutamate synthase
CDC45_RS15170	COG0069	glutamate synthase activity
CDC45_RS15180	COG3047	cAMP biosynthetic process
CDC45_RS15185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CDC45_RS15190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDC45_RS15195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDC45_RS15230	COG1965	Belongs to the frataxin family
CDC45_RS15245	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CDC45_RS15250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC45_RS15270	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC45_RS15275	COG1333	cytochrome c biogenesis protein
CDC45_RS15285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CDC45_RS15295	COG4232	protein-disulfide reductase activity
CDC45_RS15305	COG0203	ribosomal protein L17
CDC45_RS15310	COG0202	RNA polymerase activity
CDC45_RS15315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDC45_RS15320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDC45_RS15325	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDC45_RS15330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDC45_RS15335	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC45_RS15340	COG0201	protein transport
CDC45_RS15345	COG0200	Binds to the 23S rRNA
CDC45_RS15350	COG1841	ribosomal large subunit assembly
CDC45_RS15355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDC45_RS15360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDC45_RS15365	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDC45_RS15370	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDC45_RS15375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDC45_RS15380	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDC45_RS15385	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDC45_RS15390	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDC45_RS15395	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDC45_RS15400	COG0255	Belongs to the universal ribosomal protein uL29 family
CDC45_RS15405	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDC45_RS15410	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDC45_RS15415	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDC45_RS15420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDC45_RS15425	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDC45_RS15430	COG0089	rRNA binding
CDC45_RS15435	COG0088	Forms part of the polypeptide exit tunnel
CDC45_RS15440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDC45_RS15445	COG0051	transcription antitermination factor activity, RNA binding
CDC45_RS15450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC45_RS15455	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC45_RS15460	COG0049	tRNA binding
CDC45_RS15465	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDC45_RS15470	COG0514	ATP-dependent DNA helicase (RecQ)
CDC45_RS15480	COG4676	Protein conserved in bacteria
CDC45_RS15485	COG4676	Protein conserved in bacteria
CDC45_RS15490	COG5445	Predicted secreted protein (DUF2300)
CDC45_RS15495	COG2373	Large extracellular alpha-helical protein
CDC45_RS15500	COG3234	Protein of unknown function (DUF1175)
CDC45_RS15505	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CDC45_RS15510	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDC45_RS15515	COG0085	RNA polymerase activity
CDC45_RS15520	COG0222	ribosome binding
CDC45_RS15525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDC45_RS15530	COG0081	regulation of translation
CDC45_RS15535	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDC45_RS15555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC45_RS15610	COG1349	DNA-binding transcription factor activity
CDC45_RS15620	COG3842	ATPase activity
CDC45_RS15625	COG3842	ATPase activity
CDC45_RS15635	COG0395	ABC-type sugar transport system, permease component
CDC45_RS15650	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDC45_RS15670	COG2336	PFAM SpoVT AbrB
CDC45_RS15675	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC45_RS15705	COG2205	protein histidine kinase activity
CDC45_RS15710	COG0745	RESPONSE REGULATOR receiver
CDC45_RS15725	COG0668	transmembrane transport
CDC45_RS15730	COG2814	Major facilitator Superfamily
CDC45_RS15765	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDC45_RS15770	COG2197	response regulator
CDC45_RS15825	COG0745	RESPONSE REGULATOR receiver
CDC45_RS15840	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS15875	COG0475	glutathione-regulated potassium exporter activity
CDC45_RS15875	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC45_RS15910	COG1522	sequence-specific DNA binding
CDC45_RS16035	COG2925	Exonuclease
CDC45_RS16040	COG4302	ethanolamine ammonia-lyase activity
CDC45_RS16045	COG4303	Ethanolamine ammonia lyase large subunit
CDC45_RS16055	COG3284	Transcriptional regulator
CDC45_RS16065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC45_RS16090	COG0840	transmembrane signaling receptor activity
CDC45_RS16100	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS16110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC45_RS16125	COG3706	GGDEF domain
CDC45_RS16125	COG4251	negative regulation of phosphorylation
CDC45_RS16125	COG5001	Diguanylate cyclase
CDC45_RS16125	COG2203	Gaf domain
CDC45_RS16195	COG1278	Cold shock
CDC45_RS16210	COG0493	'glutamate synthase
CDC45_RS16235	COG0457	Tetratricopeptide repeat
CDC45_RS16250	COG0529	Catalyzes the synthesis of activated sulfate
CDC45_RS16270	COG1301	dicarboxylic acid transport
CDC45_RS16325	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CDC45_RS16340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC45_RS16350	COG3210	domain, Protein
CDC45_RS16470	COG4221	oxidoreductase activity
CDC45_RS16555	COG3609	addiction module antidote protein, CC2985 family
CDC45_RS16625	COG3311	Transcriptional regulator
CDC45_RS16710	COG0737	Belongs to the 5'-nucleotidase family
CDC45_RS16720	COG2010	Cytochrome c
CDC45_RS16745	COG4654	Cytochrome c, class I
CDC45_RS16755	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC45_RS16770	COG0792	nuclease activity
CDC45_RS16785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC45_RS16810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC45_RS16820	COG4266	Belongs to the allantoicase family
CDC45_RS16825	COG1301	dicarboxylic acid transport
CDC45_RS16835	COG1739	Uncharacterized protein family UPF0029
CDC45_RS16850	COG0583	DNA-binding transcription factor activity
CDC45_RS16855	COG3960	tartronate-semialdehyde synthase activity
CDC45_RS16860	COG3622	Belongs to the hyi family
CDC45_RS16870	COG2084	Dehydrogenase
CDC45_RS16875	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC45_RS16885	COG3916	Acyl-homoserine-lactone synthase
CDC45_RS16890	COG2197	response regulator
CDC45_RS16900	COG0210	DNA helicase
CDC45_RS16920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC45_RS16925	COG0509	glycine decarboxylation via glycine cleavage system
CDC45_RS16930	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC45_RS16930	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC45_RS16935	COG1760	l-serine dehydratase
CDC45_RS16950	COG1297	OPT oligopeptide transporter protein
CDC45_RS16955	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDC45_RS16965	COG0683	leucine binding
CDC45_RS16970	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC45_RS16970	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC45_RS16970	COG0506	proline dehydrogenase activity
CDC45_RS16975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDC45_RS16980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CDC45_RS17000	COG0840	transmembrane signaling receptor activity
CDC45_RS17010	COG0625	glutathione transferase activity
CDC45_RS17030	COG1832	CoA-binding protein
CDC45_RS17045	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC45_RS17050	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDC45_RS17055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDC45_RS17060	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDC45_RS17065	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDC45_RS17070	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDC45_RS17080	COG0356	it plays a direct role in the translocation of protons across the membrane
CDC45_RS17090	COG1475	DNA binding
CDC45_RS17095	COG1192	Involved in chromosome partitioning
CDC45_RS17100	COG0357	Ribosomal RNA small subunit methyltransferase G
CDC45_RS17105	COG0445	tRNA wobble uridine modification
CDC45_RS17125	COG0583	DNA-binding transcription factor activity
CDC45_RS17130	COG3530	Putative quorum-sensing-regulated virulence factor
CDC45_RS17195	COG2267	carboxylic ester hydrolase activity
CDC45_RS17200	COG0789	Transcriptional regulator
CDC45_RS17205	COG2217	Heavy metal translocating P-type atpase
CDC45_RS17215	COG3047	cAMP biosynthetic process
CDC45_RS17230	COG2423	ornithine cyclodeaminase activity
CDC45_RS17245	COG3186	Phenylalanine-4-hydroxylase
CDC45_RS17250	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDC45_RS17275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC45_RS17285	COG0737	Belongs to the 5'-nucleotidase family
CDC45_RS17290	COG0850	regulation of cytokinetic process
CDC45_RS17295	COG2894	cell division
CDC45_RS17300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDC45_RS17305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC45_RS17310	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDC45_RS17320	COG1254	Belongs to the acylphosphatase family
CDC45_RS17330	COG1116	anion transmembrane transporter activity
CDC45_RS17340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC45_RS17375	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CDC45_RS17380	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CDC45_RS17385	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CDC45_RS17390	COG2205	protein histidine kinase activity
CDC45_RS17405	COG5001	Diguanylate cyclase
CDC45_RS17405	COG4251	negative regulation of phosphorylation
CDC45_RS17405	COG3706	GGDEF domain
CDC45_RS17405	COG2203	Gaf domain
CDC45_RS17425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC45_RS17430	COG0745	RESPONSE REGULATOR receiver
CDC45_RS17460	COG1959	2 iron, 2 sulfur cluster binding
CDC45_RS17475	COG2814	Major facilitator Superfamily
CDC45_RS17490	COG0642	Histidine kinase
CDC45_RS17510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS17515	COG1126	abc transporter atp-binding protein
CDC45_RS17520	COG0765	amino acid transport
CDC45_RS17535	COG0840	transmembrane signaling receptor activity
CDC45_RS17545	COG3781	membrane
CDC45_RS17660	COG0592	DNA-directed DNA polymerase activity
CDC45_RS17665	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC45_RS17680	COG1278	Cold shock
CDC45_RS17705	COG0477	Major facilitator Superfamily
CDC45_RS17710	COG4191	Histidine kinase
CDC45_RS17720	COG4377	Putative membrane peptidase family (DUF2324)
CDC45_RS17730	COG5002	protein histidine kinase activity
CDC45_RS17730	COG3447	MASE1 domain protein
CDC45_RS17730	COG5001	Diguanylate cyclase
CDC45_RS17775	COG0038	chloride channel
CDC45_RS17790	COG1881	PFAM PEBP family protein
CDC45_RS17805	COG1914	H( )-stimulated, divalent metal cation uptake system
CDC45_RS17820	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC45_RS17845	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS17855	COG1024	Enoyl-CoA hydratase
CDC45_RS17860	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS17900	COG1760	l-serine dehydratase
CDC45_RS17930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS17935	COG0477	Major facilitator Superfamily
CDC45_RS17955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC45_RS17970	COG1902	pentaerythritol trinitrate reductase activity
CDC45_RS17970	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC45_RS17975	COG2181	nitrate reductase activity
CDC45_RS17975	COG0247	lactate metabolic process
CDC45_RS17980	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CDC45_RS17990	COG4638	Rieske (2fe-2S)
CDC45_RS18010	COG4175	Glycine betaine
CDC45_RS18015	COG4176	ABC-type proline glycine betaine transport system permease component
CDC45_RS18030	COG0243	molybdopterin cofactor binding
CDC45_RS18055	COG0477	Major facilitator Superfamily
CDC45_RS18060	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDC45_RS18065	COG3657	addiction module killer protein
CDC45_RS18070	COG2814	Major facilitator Superfamily
CDC45_RS18115	COG4974	Belongs to the 'phage' integrase family
CDC45_RS18175	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDC45_RS18190	COG0714	Associated with various cellular activities
CDC45_RS18205	COG0288	reversible hydration of carbon dioxide
CDC45_RS18210	COG0659	secondary active sulfate transmembrane transporter activity
CDC45_RS18260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CDC45_RS18305	COG0697	spore germination
CDC45_RS18320	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC45_RS18320	COG1902	pentaerythritol trinitrate reductase activity
CDC45_RS18330	COG4677	pectinesterase activity
CDC45_RS18345	COG4968	Prepilin-type N-terminal cleavage methylation domain
CDC45_RS18355	COG4796	Type ii and iii secretion system protein
CDC45_RS18380	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDC45_RS18440	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
CDC45_RS18450	COG0534	Mate efflux family protein
CDC45_RS18455	COG3251	PFAM MbtH domain protein
CDC45_RS18465	COG0529	Catalyzes the synthesis of activated sulfate
CDC45_RS18500	COG1104	cysteine desulfurase activity
CDC45_RS18565	COG2706	6-phosphogluconolactonase activity
CDC45_RS18600	COG0730	response to heat
CDC45_RS18640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC45_RS18650	COG0028	Belongs to the TPP enzyme family
CDC45_RS18665	COG1607	acyl-coa hydrolase
CDC45_RS18685	COG3039	Transposase
CDC45_RS18725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC45_RS18800	COG1846	Transcriptional regulator
CDC45_RS18805	COG1024	Enoyl-CoA hydratase
CDC45_RS18810	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS18840	COG0657	acetylesterase activity
CDC45_RS18850	COG2814	Major facilitator Superfamily
CDC45_RS18860	COG1640	4-alpha-glucanotransferase
CDC45_RS18865	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CDC45_RS18875	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CDC45_RS18880	COG0366	Alpha amylase catalytic
CDC45_RS18885	COG0366	Alpha amylase catalytic
CDC45_RS18890	COG0297	glycogen (starch) synthase activity
CDC45_RS18895	COG3720	iron ion transport
CDC45_RS18900	COG4771	TonB-dependent receptor
CDC45_RS18910	COG3634	alkyl hydroperoxide reductase activity
CDC45_RS18915	COG0735	belongs to the Fur family
CDC45_RS18935	COG1918	ferrous iron import across plasma membrane
CDC45_RS18935	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CDC45_RS18945	COG3447	MASE1 domain protein
CDC45_RS18945	COG5001	Diguanylate cyclase
CDC45_RS18945	COG5002	protein histidine kinase activity
CDC45_RS18955	COG0840	transmembrane signaling receptor activity
CDC45_RS18975	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC45_RS18990	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC45_RS19000	COG0456	acetyltransferase
CDC45_RS19000	COG0454	-acetyltransferase
CDC45_RS19070	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
CDC45_RS19090	COG3706	GGDEF domain
CDC45_RS19095	COG0531	amino acid
CDC45_RS19100	COG0534	Mate efflux family protein
CDC45_RS19115	COG2197	response regulator
CDC45_RS19125	COG0726	polysaccharide deacetylase
CDC45_RS19125	COG1649	PFAM Uncharacterised BCR, COG1649
CDC45_RS19130	COG1215	transferase activity, transferring glycosyl groups
CDC45_RS19145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS19150	COG2274	protein secretion by the type I secretion system
CDC45_RS19190	COG0840	transmembrane signaling receptor activity
CDC45_RS19205	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS19215	COG2070	2-Nitropropane dioxygenase
CDC45_RS19220	COG0583	DNA-binding transcription factor activity
CDC45_RS19225	COG1695	Transcriptional regulator
CDC45_RS19240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC45_RS19245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS19250	COG0745	RESPONSE REGULATOR receiver
CDC45_RS19255	COG2205	protein histidine kinase activity
CDC45_RS19270	COG0589	response to stress
CDC45_RS19285	COG0789	Transcriptional regulator
CDC45_RS19295	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC45_RS19320	COG1764	response to oxidative stress
CDC45_RS19335	COG0473	3-isopropylmalate dehydrogenase activity
CDC45_RS19370	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC45_RS19375	COG2188	Transcriptional regulator
CDC45_RS19380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS19385	COG2197	response regulator
CDC45_RS19405	COG1815	bacterial-type flagellum-dependent cell motility
CDC45_RS19415	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CDC45_RS19420	COG1749	Flagellar hook protein flgE
CDC45_RS19425	COG4787	bacterial-type flagellum-dependent cell motility
CDC45_RS19435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CDC45_RS19440	COG1706	bacterial-type flagellum-dependent cell motility
CDC45_RS19450	COG1256	bacterial-type flagellum assembly
CDC45_RS19470	COG2226	methyltransferase
CDC45_RS19485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC45_RS19490	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS19500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC45_RS19520	COG2986	histidine ammonia-lyase
CDC45_RS19530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC45_RS19540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC45_RS19550	COG0204	Acyl-transferase
CDC45_RS19565	COG1987	bacterial-type flagellum assembly
CDC45_RS19570	COG1338	Plays a role in the flagellum-specific transport system
CDC45_RS19600	COG2197	response regulator
CDC45_RS19625	COG1846	Transcriptional regulator
CDC45_RS19640	COG1677	Flagellar hook-basal body complex protein FliE
CDC45_RS19650	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDC45_RS19685	COG4251	negative regulation of phosphorylation
CDC45_RS19685	COG2203	Gaf domain
CDC45_RS19685	COG5001	Diguanylate cyclase
CDC45_RS19685	COG3706	GGDEF domain
CDC45_RS19695	COG2203	Gaf domain
CDC45_RS19695	COG5001	Diguanylate cyclase
CDC45_RS19695	COG4251	negative regulation of phosphorylation
CDC45_RS19695	COG3706	GGDEF domain
CDC45_RS19710	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS19760	COG2223	nitrite transmembrane transporter activity
CDC45_RS19770	COG4774	siderophore transport
CDC45_RS19785	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDC45_RS19790	COG2423	ornithine cyclodeaminase activity
CDC45_RS19795	COG4264	IucA IucC family
CDC45_RS19800	COG2814	Major facilitator Superfamily
CDC45_RS19805	COG4264	IucA IucC family
CDC45_RS19810	COG4264	IucA IucC family
CDC45_RS19820	COG0019	diaminopimelate decarboxylase activity
CDC45_RS19845	COG2814	Major facilitator Superfamily
CDC45_RS19870	COG0583	DNA-binding transcription factor activity
CDC45_RS19915	COG1902	pentaerythritol trinitrate reductase activity
CDC45_RS19925	COG0583	DNA-binding transcription factor activity
CDC45_RS20025	COG1459	type II secretion system
CDC45_RS20040	COG2165	general secretion pathway protein
CDC45_RS20080	COG3328	transposase activity
CDC45_RS20085	COG1126	abc transporter atp-binding protein
CDC45_RS20090	COG0765	amino acid transport
CDC45_RS20095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC45_RS20100	COG1522	sequence-specific DNA binding
CDC45_RS20105	COG2423	ornithine cyclodeaminase activity
CDC45_RS20130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC45_RS20165	COG0537	adenosine 5'-monophosphoramidase activity
CDC45_RS20210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC45_RS20220	COG0840	transmembrane signaling receptor activity
CDC45_RS20235	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CDC45_RS20255	COG0668	transmembrane transport
CDC45_RS20280	COG3706	GGDEF domain
CDC45_RS20285	COG1914	H( )-stimulated, divalent metal cation uptake system
CDC45_RS20290	COG0443	Heat shock 70 kDa protein
CDC45_RS20310	COG2910	NAD(P)H-binding
CDC45_RS20355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC45_RS20415	COG0402	S-adenosylhomocysteine deaminase activity
CDC45_RS20480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC45_RS20575	COG5297	Belongs to the glycosyl hydrolase family 6
CDC45_RS20600	COG0300	oxidoreductase activity
CDC45_RS20665	COG0835	chemotaxis
CDC45_RS20665	COG0784	Response regulator, receiver
CDC45_RS20690	COG1404	Belongs to the peptidase S8 family
CDC45_RS20695	COG3396	Phenylacetate-CoA oxygenase
CDC45_RS20700	COG3460	Phenylacetate-CoA oxygenase
CDC45_RS20705	COG3396	Phenylacetate-CoA oxygenase
CDC45_RS20710	COG2151	metal-sulfur cluster biosynthetic enzyme
CDC45_RS20715	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC45_RS20745	COG0778	Nitroreductase
CDC45_RS20750	COG1797	cobyrinic acid a,c-diamide synthase activity
CDC45_RS20785	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CDC45_RS20795	COG1648	precorrin-2 dehydrogenase activity
CDC45_RS20795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC45_RS20815	COG3411	Ferredoxin
CDC45_RS20820	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CDC45_RS20855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CDC45_RS20860	COG4941	Belongs to the sigma-70 factor family
CDC45_RS20875	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CDC45_RS20880	COG3251	PFAM MbtH domain protein
CDC45_RS20900	COG1522	sequence-specific DNA binding
CDC45_RS20905	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CDC45_RS20910	COG1024	Enoyl-CoA hydratase
CDC45_RS20915	COG1024	Enoyl-CoA hydratase
CDC45_RS20930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC45_RS20935	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS20945	COG5002	protein histidine kinase activity
CDC45_RS20950	COG0745	RESPONSE REGULATOR receiver
CDC45_RS20980	COG1335	isochorismatase
CDC45_RS20990	COG2814	Major facilitator Superfamily
CDC45_RS21005	COG2818	Glycosylase
CDC45_RS21010	COG2807	transmembrane transport
CDC45_RS21035	COG1024	Enoyl-CoA hydratase
CDC45_RS21060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CDC45_RS21065	COG0583	DNA-binding transcription factor activity
CDC45_RS21070	COG0259	pyridoxamine-phosphate oxidase activity
CDC45_RS21075	COG0019	diaminopimelate decarboxylase activity
CDC45_RS21080	COG0134	indole-3-glycerol-phosphate synthase activity
CDC45_RS21085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC45_RS21115	COG1960	acyl-CoA dehydrogenase activity
CDC45_RS21135	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CDC45_RS21150	COG3483	tryptophan 2,3-dioxygenase activity
CDC45_RS21160	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDC45_RS21175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDC45_RS21180	COG1690	Belongs to the RtcB family
CDC45_RS21265	COG1858	cytochrome C peroxidase
CDC45_RS21270	COG1730	sister chromatid segregation
CDC45_RS21285	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CDC45_RS21320	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CDC45_RS21450	COG1649	PFAM Uncharacterised BCR, COG1649
CDC45_RS21535	COG2197	response regulator
CDC45_RS21540	COG3916	Acyl-homoserine-lactone synthase
CDC45_RS21555	COG0525	valine-tRNA ligase activity
CDC45_RS21580	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS21585	COG2192	nodulation
CDC45_RS21600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC45_RS21600	COG3321	synthase
CDC45_RS21600	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS21600	COG0300	oxidoreductase activity
CDC45_RS21600	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS21615	COG0436	Aminotransferase
CDC45_RS21630	COG2814	Major facilitator Superfamily
CDC45_RS21645	COG0587	DNA-directed DNA polymerase activity
CDC45_RS21650	COG3620	sequence-specific DNA binding
CDC45_RS21655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CDC45_RS21665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC45_RS21680	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC45_RS21695	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC45_RS21700	COG4206	TonB-dependent receptor
CDC45_RS21715	COG0579	oxidoreductase
CDC45_RS21725	COG1309	transcriptional regulator
CDC45_RS21735	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC45_RS21750	COG0697	spore germination
CDC45_RS21760	COG0583	DNA-binding transcription factor activity
CDC45_RS21770	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC45_RS21775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC45_RS21785	COG2271	Major facilitator Superfamily
CDC45_RS21795	COG2721	sulfolactate sulfo-lyase activity
CDC45_RS21800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC45_RS21815	COG2271	Major facilitator Superfamily
CDC45_RS21820	COG1051	belongs to the nudix hydrolase family
CDC45_RS21820	COG1056	cytidyltransferase-related domain
CDC45_RS21845	COG0840	transmembrane signaling receptor activity
CDC45_RS21895	COG1595	DNA-templated transcription, initiation
CDC45_RS21905	COG2197	response regulator
CDC45_RS21910	COG0745	RESPONSE REGULATOR receiver
CDC45_RS21950	COG4790	Type iii secretion
CDC45_RS21965	COG4789	Type iii secretion
CDC45_RS21970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDC45_RS22015	COG2207	Transcriptional regulator
CDC45_RS22020	COG1450	Type ii and iii secretion system protein
CDC45_RS22025	COG4886	Leucine-rich repeat (LRR) protein
CDC45_RS22050	COG5434	Belongs to the glycosyl hydrolase 28 family
CDC45_RS22070	COG1674	ftsk spoiiie
CDC45_RS22115	COG1942	4-Oxalocrotonate Tautomerase
CDC45_RS22120	COG4569	acetaldehyde dehydrogenase (acetylating) activity
CDC45_RS22125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC45_RS22130	COG2271	Major facilitator Superfamily
CDC45_RS22140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDC45_RS22155	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC45_RS22200	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC45_RS22205	COG0583	DNA-binding transcription factor activity
CDC45_RS22225	COG2853	Lipoprotein
CDC45_RS22285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS22305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC45_RS22310	COG1126	abc transporter atp-binding protein
CDC45_RS22315	COG0765	amino acid transport
CDC45_RS22320	COG0765	amino acid transport
CDC45_RS22325	COG4221	oxidoreductase activity
CDC45_RS22330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC45_RS22340	COG1984	allophanate hydrolase subunit 2
CDC45_RS22345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC45_RS22355	COG0511	ligase activity, forming carbon-carbon bonds
CDC45_RS22365	COG0436	Aminotransferase
CDC45_RS22370	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC45_RS22375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC45_RS22380	COG3265	gluconokinase activity
CDC45_RS22385	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS22390	COG1063	alcohol dehydrogenase
CDC45_RS22425	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS22465	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
CDC45_RS22470	COG3604	Transcriptional regulator
CDC45_RS22475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC45_RS22485	COG1396	sequence-specific DNA binding
CDC45_RS22515	COG3154	lipid carrier protein
CDC45_RS22520	COG0826	peptidase U32
CDC45_RS22525	COG0826	peptidase U32
CDC45_RS22540	COG2223	nitrite transmembrane transporter activity
CDC45_RS22545	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CDC45_RS22550	COG1140	nitrate reductase beta subunit
CDC45_RS22555	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CDC45_RS22560	COG2181	nitrate reductase activity
CDC45_RS22565	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC45_RS22570	COG3850	Histidine kinase
CDC45_RS22575	COG2197	response regulator
CDC45_RS22595	COG0352	thiamine-phosphate diphosphorylase activity
CDC45_RS22600	COG0477	Major facilitator Superfamily
CDC45_RS22605	COG1454	alcohol dehydrogenase
CDC45_RS22620	COG1999	signal sequence binding
CDC45_RS22645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CDC45_RS22650	COG1301	dicarboxylic acid transport
CDC45_RS22660	COG0583	DNA-binding transcription factor activity
CDC45_RS22700	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC45_RS22710	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDC45_RS22730	COG0110	maltose O-acetyltransferase activity
CDC45_RS22745	COG2244	polysaccharide biosynthetic process
CDC45_RS22750	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CDC45_RS22755	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CDC45_RS22760	COG3206	protein involved in exopolysaccharide biosynthesis
CDC45_RS22760	COG0489	protein tyrosine kinase activity
CDC45_RS22765	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC45_RS22770	COG1596	polysaccharide export
CDC45_RS22860	COG3220	belongs to the UPF0276 family
CDC45_RS22895	COG0745	RESPONSE REGULATOR receiver
CDC45_RS22920	COG2223	nitrite transmembrane transporter activity
CDC45_RS22925	COG0243	molybdopterin cofactor binding
CDC45_RS22935	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC45_RS22940	COG5001	Diguanylate cyclase
CDC45_RS22940	COG3300	MHYT domain
CDC45_RS22945	COG3158	transport of potassium into the cell
CDC45_RS22950	COG1278	Cold shock
CDC45_RS22965	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC45_RS22975	COG4689	acetoacetate decarboxylase
CDC45_RS22980	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS22990	COG0673	inositol 2-dehydrogenase activity
CDC45_RS23045	COG3210	domain, Protein
CDC45_RS23055	COG2831	hemolysin activation secretion protein
CDC45_RS23065	COG0673	inositol 2-dehydrogenase activity
CDC45_RS23120	COG4964	Belongs to the GSP D family
CDC45_RS23160	COG2197	response regulator
CDC45_RS23185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC45_RS23190	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC45_RS23195	COG1877	trehalose-phosphatase activity
CDC45_RS23200	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CDC45_RS23205	COG1846	Transcriptional regulator
CDC45_RS23210	COG1764	response to oxidative stress
CDC45_RS23225	COG0583	DNA-binding transcription factor activity
CDC45_RS23235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS23245	COG1538	Outer membrane efflux protein
CDC45_RS23280	COG2030	dehydratase
CDC45_RS23300	COG1064	alcohol dehydrogenase
CDC45_RS23315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CDC45_RS23320	COG0640	Transcriptional regulator
CDC45_RS23365	COG3209	COG3209 Rhs family protein
CDC45_RS23365	COG4104	PAAR repeat-containing protein
CDC45_RS23385	COG2197	response regulator
CDC45_RS23395	COG2066	Belongs to the glutaminase family
CDC45_RS23400	COG4149	molybdate abc transporter
CDC45_RS23405	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC45_RS23440	COG1942	4-Oxalocrotonate Tautomerase
CDC45_RS23460	COG3300	MHYT domain
CDC45_RS23460	COG5001	Diguanylate cyclase
CDC45_RS23480	COG3813	Protein conserved in bacteria
CDC45_RS23495	COG0745	RESPONSE REGULATOR receiver
CDC45_RS23500	COG2205	protein histidine kinase activity
CDC45_RS23530	COG1858	cytochrome C peroxidase
CDC45_RS23550	COG1253	flavin adenine dinucleotide binding
CDC45_RS23555	COG1858	cytochrome C peroxidase
CDC45_RS23585	COG2205	protein histidine kinase activity
CDC45_RS23585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC45_RS23595	COG3039	Transposase
CDC45_RS23615	COG2274	protein secretion by the type I secretion system
CDC45_RS23640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CDC45_RS23655	COG0800	Aldolase
CDC45_RS23660	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC45_RS23665	COG2197	response regulator
CDC45_RS23735	COG1294	oxidase, subunit
CDC45_RS23740	COG1271	oxidase subunit
CDC45_RS23745	COG3300	MHYT domain
CDC45_RS23745	COG5001	Diguanylate cyclase
CDC45_RS23750	COG0840	transmembrane signaling receptor activity
CDC45_RS23760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC45_RS23770	COG0534	Mate efflux family protein
CDC45_RS23795	COG0243	molybdopterin cofactor binding
CDC45_RS23800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC45_RS23810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC45_RS23815	COG2223	nitrite transmembrane transporter activity
CDC45_RS23820	COG0840	transmembrane signaling receptor activity
CDC45_RS23825	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC45_RS23835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC45_RS23860	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC45_RS23865	COG0436	Aminotransferase
CDC45_RS23870	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC45_RS23870	COG0473	3-isopropylmalate dehydrogenase activity
CDC45_RS23905	COG2951	lytic endotransglycosylase activity
CDC45_RS23915	COG1271	oxidase subunit
CDC45_RS23920	COG1294	oxidase, subunit
CDC45_RS23925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC45_RS23935	COG0251	oxidation-reduction process
CDC45_RS23970	COG3550	peptidyl-serine autophosphorylation
CDC45_RS23990	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDC45_RS24010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC45_RS24015	COG0730	response to heat
CDC45_RS24020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC45_RS24035	COG0730	response to heat
CDC45_RS24065	COG0668	transmembrane transport
CDC45_RS24070	COG1742	UPF0060 membrane protein
CDC45_RS24090	COG0477	Major facilitator Superfamily
CDC45_RS24095	COG0114	fumarate hydratase activity
CDC45_RS24120	COG1621	beta-fructofuranosidase activity
CDC45_RS24130	COG1609	Transcriptional regulator
CDC45_RS24170	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CDC45_RS24190	COG3766	membrane
CDC45_RS24240	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC45_RS24300	COG0251	oxidation-reduction process
CDC45_RS24310	COG1522	sequence-specific DNA binding
CDC45_RS24315	COG0640	Transcriptional regulator
CDC45_RS24330	COG1280	lysine exporter protein (LysE YggA)
CDC45_RS24335	COG0251	oxidation-reduction process
CDC45_RS24350	COG0583	DNA-binding transcription factor activity
CDC45_RS24360	COG2814	Major facilitator Superfamily
CDC45_RS24400	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC45_RS24460	COG0251	oxidation-reduction process
CDC45_RS24470	COG1522	sequence-specific DNA binding
CDC45_RS24475	COG0640	Transcriptional regulator
CDC45_RS24490	COG1280	lysine exporter protein (LysE YggA)
CDC45_RS24495	COG0251	oxidation-reduction process
CDC45_RS24510	COG0583	DNA-binding transcription factor activity
CDC45_RS24520	COG2814	Major facilitator Superfamily
CDC45_RS24535	COG0840	transmembrane signaling receptor activity
CDC45_RS24540	COG0567	Dehydrogenase, E1 component
CDC45_RS24545	COG0204	Acyl-transferase
CDC45_RS24560	COG4263	nitrous-oxide reductase activity
CDC45_RS24625	COG2824	Alkylphosphonate utilization operon protein PhnA
CDC45_RS24635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC45_RS24645	COG0762	integral membrane protein
CDC45_RS24670	COG1191	sigma factor activity
CDC45_RS24685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDC45_RS24695	COG1309	transcriptional regulator
CDC45_RS24700	COG2271	Major facilitator Superfamily
CDC45_RS24705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC45_RS24710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC45_RS24715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS24725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC45_RS24730	COG0745	RESPONSE REGULATOR receiver
CDC45_RS24735	COG2201	protein-glutamate methylesterase activity
CDC45_RS24740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CDC45_RS24750	COG0840	transmembrane signaling receptor activity
CDC45_RS24755	COG0835	chemotaxis
CDC45_RS24765	COG0745	RESPONSE REGULATOR receiver
CDC45_RS24770	COG1360	Flagellar Motor Protein
CDC45_RS24800	COG0477	Major facilitator Superfamily
CDC45_RS24805	COG2267	carboxylic ester hydrolase activity
CDC45_RS24810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC45_RS24810	COG0300	oxidoreductase activity
CDC45_RS24810	COG1028	Short-chain dehydrogenase reductase Sdr
CDC45_RS24810	COG3321	synthase
CDC45_RS24810	COG0318	PFAM AMP-dependent synthetase and ligase
CDC45_RS24815	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC45_RS24825	COG0644	oxidoreductase
CDC45_RS24830	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDC45_RS24835	COG3486	L-lysine 6-monooxygenase (NADPH) activity
CDC45_RS24865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS24865	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC45_RS24900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC45_RS24900	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC45_RS24915	COG2205	protein histidine kinase activity
CDC45_RS24940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC45_RS24950	COG0469	pyruvate kinase activity
CDC45_RS24960	COG0583	DNA-binding transcription factor activity
CDC45_RS24970	COG2205	protein histidine kinase activity
CDC45_RS24975	COG0745	RESPONSE REGULATOR receiver
CDC45_RS24995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CDC45_RS25020	COG1136	(ABC) transporter
CDC45_RS25025	COG0577	efflux transmembrane transporter activity
CDC45_RS25025	COG1136	(ABC) transporter
CDC45_RS25065	COG0667	Aldo Keto reductase
CDC45_RS25140	COG2192	nodulation
CDC45_RS25155	COG2192	nodulation
CDC45_RS25170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC45_RS25170	COG4651	solute:proton antiporter activity
CDC45_RS25215	COG3256	nitric oxide reductase
CDC45_RS25220	COG2188	Transcriptional regulator
CDC45_RS25225	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
CDC45_RS25230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC45_RS25265	COG0583	DNA-binding transcription factor activity
CDC45_RS25320	COG0705	Rhomboid family
CDC45_RS25340	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CDC45_RS25365	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC45_RS25375	COG3210	domain, Protein
CDC45_RS25445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC45_RS25450	COG0642	Histidine kinase
CDC45_RS25470	COG0837	glucose binding
CDC45_RS25480	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CDC45_RS25490	COG0589	response to stress
CDC45_RS25505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC45_RS25510	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC45_RS25520	COG1845	cytochrome c oxidase, subunit III
CDC45_RS25545	COG2271	Major facilitator Superfamily
CDC45_RS25560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC45_RS25570	COG0765	amino acid transport
CDC45_RS25575	COG0010	Belongs to the arginase family
CDC45_RS25580	COG2197	response regulator
CDC45_RS25620	COG2826	transposase and inactivated derivatives, IS30 family
CDC45_RS25625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC45_RS25630	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS25640	COG0583	DNA-binding transcription factor activity
CDC45_RS25645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC45_RS25650	COG2814	Major facilitator Superfamily
CDC45_RS25665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC45_RS25725	COG1012	belongs to the aldehyde dehydrogenase family
CDC45_RS25730	COG0473	3-isopropylmalate dehydrogenase activity
CDC45_RS25740	COG2271	Major facilitator Superfamily
CDC45_RS25745	COG2721	sulfolactate sulfo-lyase activity
CDC45_RS25755	COG1475	DNA binding
CDC45_RS25765	COG3969	phosphoadenosine phosphosulfate
CDC45_RS25770	COG5295	Hep Hag repeat protein
CDC45_RS25770	COG5295	Hep Hag repeat protein
CDC45_RS25780	COG2205	protein histidine kinase activity
CDC45_RS25780	COG0784	Response regulator, receiver
CDC45_RS25785	COG4251	negative regulation of phosphorylation
CDC45_RS25785	COG2203	Gaf domain
CDC45_RS25785	COG3706	GGDEF domain
CDC45_RS25785	COG5001	Diguanylate cyclase
CDC45_RS25795	COG2801	Transposase and inactivated derivatives
CDC45_RS25825	COG4213	ABC transporter substrate-binding protein
CDC45_RS25830	COG1129	ABC transporter
CDC45_RS25835	COG4214	carbohydrate transport
CDC45_RS25840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC45_RS25845	COG1609	Transcriptional regulator
CDC45_RS25935	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC45_RS25945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC45_RS25955	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDC45_RS25980	COG2204	response regulator
CDC45_RS25995	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC45_RS26020	COG2205	protein histidine kinase activity
CDC45_RS26030	COG2252	PERMEase