locus-tag	class	description
G7969_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7969_RS00010	COG0592	DNA-directed DNA polymerase activity
G7969_RS00040	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G7969_RS00095	COG3781	membrane
G7969_RS00125	COG1126	abc transporter atp-binding protein
G7969_RS00130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS00145	COG0745	RESPONSE REGULATOR receiver
G7969_RS00150	COG0642	Histidine kinase
G7969_RS00165	COG2814	Major facilitator Superfamily
G7969_RS00180	COG1959	2 iron, 2 sulfur cluster binding
G7969_RS00205	COG0745	RESPONSE REGULATOR receiver
G7969_RS00210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7969_RS00230	COG3706	GGDEF domain
G7969_RS00230	COG5001	Diguanylate cyclase
G7969_RS00230	COG4251	negative regulation of phosphorylation
G7969_RS00230	COG2203	Gaf domain
G7969_RS00240	COG2205	protein histidine kinase activity
G7969_RS00245	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G7969_RS00250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
G7969_RS00255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G7969_RS00290	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7969_RS00300	COG1116	anion transmembrane transporter activity
G7969_RS00310	COG1254	Belongs to the acylphosphatase family
G7969_RS00320	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G7969_RS00325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7969_RS00330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G7969_RS00335	COG2894	cell division
G7969_RS00340	COG0850	regulation of cytokinetic process
G7969_RS00345	COG0737	Belongs to the 5'-nucleotidase family
G7969_RS00355	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G7969_RS00380	COG2154	pterin-4-alpha-carbinolamine dehydratase
G7969_RS00385	COG3186	Phenylalanine-4-hydroxylase
G7969_RS00400	COG2423	ornithine cyclodeaminase activity
G7969_RS00410	COG3047	cAMP biosynthetic process
G7969_RS00420	COG2217	Heavy metal translocating P-type atpase
G7969_RS00425	COG0789	Transcriptional regulator
G7969_RS00430	COG2267	carboxylic ester hydrolase activity
G7969_RS00495	COG3530	Putative quorum-sensing-regulated virulence factor
G7969_RS00500	COG0583	DNA-binding transcription factor activity
G7969_RS00520	COG0445	tRNA wobble uridine modification
G7969_RS00525	COG0357	Ribosomal RNA small subunit methyltransferase G
G7969_RS00530	COG1192	Involved in chromosome partitioning
G7969_RS00535	COG1475	DNA binding
G7969_RS00545	COG0356	it plays a direct role in the translocation of protons across the membrane
G7969_RS00555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G7969_RS00560	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G7969_RS00565	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G7969_RS00570	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G7969_RS00575	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G7969_RS00580	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7969_RS00595	COG1832	CoA-binding protein
G7969_RS00615	COG0625	glutathione transferase activity
G7969_RS00645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G7969_RS00650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G7969_RS00655	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7969_RS00655	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G7969_RS00655	COG0506	proline dehydrogenase activity
G7969_RS00660	COG0683	leucine binding
G7969_RS00670	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G7969_RS00675	COG1297	OPT oligopeptide transporter protein
G7969_RS00680	COG1760	l-serine dehydratase
G7969_RS00685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7969_RS00685	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G7969_RS00690	COG0509	glycine decarboxylation via glycine cleavage system
G7969_RS00695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7969_RS00715	COG0210	DNA helicase
G7969_RS00725	COG2197	response regulator
G7969_RS00730	COG3916	Acyl-homoserine-lactone synthase
G7969_RS00740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7969_RS00745	COG2084	Dehydrogenase
G7969_RS00750	COG3622	Belongs to the hyi family
G7969_RS00755	COG3960	tartronate-semialdehyde synthase activity
G7969_RS00760	COG0583	DNA-binding transcription factor activity
G7969_RS00775	COG1739	Uncharacterized protein family UPF0029
G7969_RS00785	COG1301	dicarboxylic acid transport
G7969_RS00790	COG4266	Belongs to the allantoicase family
G7969_RS00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7969_RS00825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7969_RS00840	COG0792	nuclease activity
G7969_RS00855	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7969_RS00865	COG4654	Cytochrome c, class I
G7969_RS00890	COG2010	Cytochrome c
G7969_RS00895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7969_RS00900	COG0737	Belongs to the 5'-nucleotidase family
G7969_RS00910	COG3039	Transposase
G7969_RS00975	COG1301	dicarboxylic acid transport
G7969_RS00980	COG0583	DNA-binding transcription factor activity
G7969_RS00990	COG2814	Major facilitator Superfamily
G7969_RS00995	COG1280	lysine exporter protein (LysE YggA)
G7969_RS01015	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
G7969_RS01020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS01025	COG0402	S-adenosylhomocysteine deaminase activity
G7969_RS01045	COG3039	Transposase
G7969_RS01060	COG0529	Catalyzes the synthesis of activated sulfate
G7969_RS01075	COG0457	Tetratricopeptide repeat
G7969_RS01100	COG0493	'glutamate synthase
G7969_RS01110	COG3385	transposase activity
G7969_RS01115	COG1278	Cold shock
G7969_RS01185	COG3706	GGDEF domain
G7969_RS01185	COG5001	Diguanylate cyclase
G7969_RS01185	COG2203	Gaf domain
G7969_RS01185	COG4251	negative regulation of phosphorylation
G7969_RS01200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7969_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS01220	COG0840	transmembrane signaling receptor activity
G7969_RS01245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7969_RS01255	COG3284	Transcriptional regulator
G7969_RS01260	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS01265	COG4303	Ethanolamine ammonia lyase large subunit
G7969_RS01270	COG4302	ethanolamine ammonia-lyase activity
G7969_RS01275	COG2925	Exonuclease
G7969_RS01390	COG1522	sequence-specific DNA binding
G7969_RS01395	COG1404	Belongs to the peptidase S8 family
G7969_RS01420	COG0475	glutathione-regulated potassium exporter activity
G7969_RS01420	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7969_RS01445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS01455	COG0745	RESPONSE REGULATOR receiver
G7969_RS01505	COG2197	response regulator
G7969_RS01510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G7969_RS01545	COG2814	Major facilitator Superfamily
G7969_RS01550	COG0668	transmembrane transport
G7969_RS01570	COG0745	RESPONSE REGULATOR receiver
G7969_RS01575	COG2205	protein histidine kinase activity
G7969_RS01605	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G7969_RS01610	COG2336	PFAM SpoVT AbrB
G7969_RS01630	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G7969_RS01645	COG0395	ABC-type sugar transport system, permease component
G7969_RS01655	COG3842	ATPase activity
G7969_RS01660	COG3842	ATPase activity
G7969_RS01670	COG1349	DNA-binding transcription factor activity
G7969_RS01720	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7969_RS01740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G7969_RS01745	COG0081	regulation of translation
G7969_RS01750	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G7969_RS01755	COG0222	ribosome binding
G7969_RS01760	COG0085	RNA polymerase activity
G7969_RS01765	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G7969_RS01770	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
G7969_RS01775	COG3234	Protein of unknown function (DUF1175)
G7969_RS01780	COG2373	Large extracellular alpha-helical protein
G7969_RS01785	COG5445	Predicted secreted protein (DUF2300)
G7969_RS01790	COG4676	Protein conserved in bacteria
G7969_RS01795	COG4676	Protein conserved in bacteria
G7969_RS01805	COG0514	ATP-dependent DNA helicase (RecQ)
G7969_RS01810	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G7969_RS01815	COG0049	tRNA binding
G7969_RS01820	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7969_RS01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G7969_RS01830	COG0051	transcription antitermination factor activity, RNA binding
G7969_RS01835	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G7969_RS01840	COG0088	Forms part of the polypeptide exit tunnel
G7969_RS01845	COG0089	rRNA binding
G7969_RS01850	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G7969_RS01855	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G7969_RS01860	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G7969_RS01865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G7969_RS01870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G7969_RS01875	COG0255	Belongs to the universal ribosomal protein uL29 family
G7969_RS01880	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G7969_RS01885	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G7969_RS01890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G7969_RS01895	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G7969_RS01900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G7969_RS01905	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G7969_RS01910	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G7969_RS01915	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G7969_RS01920	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G7969_RS01925	COG1841	ribosomal large subunit assembly
G7969_RS01930	COG0200	Binds to the 23S rRNA
G7969_RS01935	COG0201	protein transport
G7969_RS01940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7969_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G7969_RS01950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G7969_RS01955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G7969_RS01960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G7969_RS01965	COG0202	RNA polymerase activity
G7969_RS01970	COG0203	ribosomal protein L17
G7969_RS01980	COG4232	protein-disulfide reductase activity
G7969_RS01990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G7969_RS02000	COG1333	cytochrome c biogenesis protein
G7969_RS02005	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G7969_RS02025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G7969_RS02030	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G7969_RS02045	COG1965	Belongs to the frataxin family
G7969_RS02080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G7969_RS02085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G7969_RS02090	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G7969_RS02095	COG3047	cAMP biosynthetic process
G7969_RS02105	COG0069	glutamate synthase activity
G7969_RS02105	COG0067	glutamate synthase
G7969_RS02105	COG0070	glutamate synthase
G7969_RS02120	COG1127	ABC transporter
G7969_RS02125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7969_RS02130	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7969_RS02150	COG1131	(ABC) transporter
G7969_RS02155	COG0842	Transport permease protein
G7969_RS02165	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G7969_RS02170	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G7969_RS02175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G7969_RS02180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7969_RS02185	COG0131	Imidazoleglycerol-phosphate dehydratase
G7969_RS02190	COG2095	MarC family integral membrane protein
G7969_RS02195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G7969_RS02200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G7969_RS02205	COG0107	imidazoleglycerol-phosphate synthase activity
G7969_RS02210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G7969_RS02215	COG0140	phosphoribosyl-ATP diphosphatase activity
G7969_RS02225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7969_RS02230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G7969_RS02235	COG0805	protein transport
G7969_RS02240	COG3842	ATPase activity
G7969_RS02250	COG1840	ABC-type Fe3 transport system, periplasmic component
G7969_RS02255	COG0642	Histidine kinase
G7969_RS02270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS02275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7969_RS02280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G7969_RS02285	COG1970	mechanosensitive ion channel activity
G7969_RS02290	COG0723	plastoquinol--plastocyanin reductase activity
G7969_RS02295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G7969_RS02300	COG2857	Cytochrome c1
G7969_RS02305	COG0625	glutathione transferase activity
G7969_RS02310	COG2969	positive regulation of protein catabolic process
G7969_RS02380	COG5377	YqaJ viral recombinase family
G7969_RS02415	COG0556	nucleotide-excision repair
G7969_RS02430	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G7969_RS02440	COG0582	viral genome integration into host DNA
G7969_RS02460	COG0405	Gamma-glutamyltransferase
G7969_RS02470	COG3712	iron ion homeostasis
G7969_RS02480	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G7969_RS02495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G7969_RS02500	COG0488	(ABC) transporter
G7969_RS02520	COG2943	transferase activity, transferring hexosyl groups
G7969_RS02520	COG3416	Protein conserved in bacteria
G7969_RS02525	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G7969_RS02545	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G7969_RS02550	COG2890	protein-(glutamine-N5) methyltransferase activity
G7969_RS02560	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G7969_RS02565	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G7969_RS02575	COG0012	GTP binding
G7969_RS02600	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7969_RS02610	COG0604	alcohol dehydrogenase
G7969_RS02620	COG1289	transmembrane transporter activity
G7969_RS02635	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G7969_RS02645	COG0134	indole-3-glycerol-phosphate synthase activity
G7969_RS02650	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7969_RS02660	COG0512	Glutamine amidotransferase of anthranilate synthase
G7969_RS02670	COG0546	phosphoglycolate phosphatase activity
G7969_RS02675	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G7969_RS02680	COG2967	ApaG domain
G7969_RS02700	COG2050	protein possibly involved in aromatic compounds catabolism
G7969_RS02705	COG1024	Enoyl-CoA hydratase
G7969_RS02710	COG1024	Enoyl-CoA hydratase
G7969_RS02740	COG1473	amidohydrolase
G7969_RS02745	COG0747	negative chemotaxis
G7969_RS02750	COG0601	transmembrane transport
G7969_RS02755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7969_RS02760	COG0444	Belongs to the ABC transporter superfamily
G7969_RS02765	COG4608	Belongs to the ABC transporter superfamily
G7969_RS02775	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7969_RS02775	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G7969_RS02780	COG1105	Belongs to the carbohydrate kinase PfkB family
G7969_RS02785	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7969_RS02785	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7969_RS02790	COG1609	Transcriptional regulator
G7969_RS02795	COG0243	molybdopterin cofactor binding
G7969_RS02805	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS02810	COG0477	Major facilitator Superfamily
G7969_RS02815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS02820	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G7969_RS02825	COG2001	Belongs to the MraZ family
G7969_RS02830	COG0275	rRNA processing
G7969_RS02845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G7969_RS02850	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G7969_RS02855	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7969_RS02860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G7969_RS02870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G7969_RS02875	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7969_RS02880	COG1181	Belongs to the D-alanine--D-alanine ligase family
G7969_RS02885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G7969_RS02900	COG0678	peroxiredoxin activity
G7969_RS02905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G7969_RS02915	COG0739	heme binding
G7969_RS02920	COG0653	protein targeting
G7969_RS02925	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G7969_RS02935	COG0494	nUDIX hydrolase
G7969_RS02940	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G7969_RS02945	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G7969_RS02950	COG0237	dephospho-CoA kinase activity
G7969_RS02960	COG1459	type II secretion system
G7969_RS02970	COG4536	flavin adenine dinucleotide binding
G7969_RS02980	COG0142	geranyltranstransferase activity
G7969_RS02985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G7969_RS02990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G7969_RS02995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G7969_RS03000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G7969_RS03010	COG0494	nUDIX hydrolase
G7969_RS03015	COG0442	prolyl-tRNA aminoacylation
G7969_RS03020	COG0741	lytic transglycosylase activity
G7969_RS03030	COG2095	MarC family integral membrane protein
G7969_RS03040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G7969_RS03065	COG3023	N-Acetylmuramoyl-L-alanine amidase
G7969_RS03090	COG1522	sequence-specific DNA binding
G7969_RS03100	COG0840	transmembrane signaling receptor activity
G7969_RS03140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7969_RS03145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G7969_RS03155	COG2264	protein methyltransferase activity
G7969_RS03165	COG0511	ligase activity, forming carbon-carbon bonds
G7969_RS03170	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G7969_RS03175	COG3118	belongs to the thioredoxin family
G7969_RS03185	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G7969_RS03190	COG3150	esterase
G7969_RS03195	COG3161	chorismate lyase activity
G7969_RS03200	COG0557	exoribonuclease II activity
G7969_RS03210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7969_RS03215	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G7969_RS03230	COG0284	orotidine-5'-phosphate decarboxylase activity
G7969_RS03240	COG1546	Belongs to the CinA family
G7969_RS03240	COG1058	Belongs to the CinA family
G7969_RS03245	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G7969_RS03255	COG0281	malic enzyme
G7969_RS03255	COG0280	phosphate acetyltransferase
G7969_RS03275	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G7969_RS03285	COG0583	DNA-binding transcription factor activity
G7969_RS03290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS03305	COG1129	ABC transporter
G7969_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS03330	COG0800	Aldolase
G7969_RS03335	COG4948	Mandelate Racemase Muconate Lactonizing
G7969_RS03340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G7969_RS03345	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G7969_RS03350	COG0583	DNA-binding transcription factor activity
G7969_RS03355	COG0735	belongs to the Fur family
G7969_RS03360	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G7969_RS03365	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G7969_RS03370	COG0495	leucyl-tRNA aminoacylation
G7969_RS03380	COG1466	dna polymerase III delta subunit
G7969_RS03385	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G7969_RS03400	COG2204	response regulator
G7969_RS03405	COG4191	Histidine kinase
G7969_RS03410	COG4191	Histidine kinase
G7969_RS03435	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G7969_RS03455	COG2814	Major facilitator Superfamily
G7969_RS03475	COG0482	sulfurtransferase activity
G7969_RS03480	COG0069	glutamate synthase activity
G7969_RS03485	COG0625	glutathione transferase activity
G7969_RS03495	COG3038	cytochrome b561
G7969_RS03500	COG2353	YceI-like domain
G7969_RS03505	COG2353	YceI-like domain
G7969_RS03510	COG3385	transposase activity
G7969_RS03515	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7969_RS03520	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G7969_RS03525	COG1862	Preprotein translocase
G7969_RS03530	COG0343	queuine tRNA-ribosyltransferase activity
G7969_RS03535	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G7969_RS03540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G7969_RS03575	COG1522	sequence-specific DNA binding
G7969_RS03580	COG1473	amidohydrolase
G7969_RS03585	COG1819	glycosyl
G7969_RS03590	COG3039	Transposase
G7969_RS03640	COG1278	Cold shock
G7969_RS03730	COG0783	Belongs to the Dps family
G7969_RS03735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G7969_RS03795	COG0386	Belongs to the glutathione peroxidase family
G7969_RS03815	COG1346	cytolysis
G7969_RS03820	COG1380	Effector of murein hydrolase LrgA
G7969_RS03825	COG0247	lactate metabolic process
G7969_RS03830	COG0277	FAD linked oxidase domain protein
G7969_RS03835	COG0277	FAD linked oxidase domain protein
G7969_RS03840	COG0583	DNA-binding transcription factor activity
G7969_RS03845	COG0277	FAD linked oxidase domain protein
G7969_RS03850	COG2096	Adenosyltransferase
G7969_RS03855	COG0668	transmembrane transport
G7969_RS03865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7969_RS03870	COG0312	modulator of DNA gyrase
G7969_RS03875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G7969_RS03885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G7969_RS03900	COG1404	Belongs to the peptidase S8 family
G7969_RS03910	COG0497	DNA recombination
G7969_RS03915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G7969_RS03920	COG1420	regulation of RNA biosynthetic process
G7969_RS03930	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G7969_RS03935	COG2986	histidine ammonia-lyase
G7969_RS03940	COG0010	Belongs to the arginase family
G7969_RS03945	COG1228	amidohydrolase
G7969_RS03950	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G7969_RS03965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G7969_RS03975	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7969_RS03980	COG0443	Heat shock 70 kDa protein
G7969_RS03985	COG0484	heat shock protein binding
G7969_RS03990	COG0512	Glutamine amidotransferase of anthranilate synthase
G7969_RS03990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G7969_RS03995	COG1122	ATPase activity
G7969_RS04000	COG4662	Binding-protein-dependent transport system inner membrane component
G7969_RS04005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G7969_RS04015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G7969_RS04030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G7969_RS04035	COG0628	permease
G7969_RS04040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G7969_RS04055	COG2169	Transcriptional regulator
G7969_RS04055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7969_RS04075	COG2169	Transcriptional regulator
G7969_RS04075	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G7969_RS04080	COG0456	acetyltransferase
G7969_RS04085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7969_RS04090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G7969_RS04095	COG3008	intermembrane lipid transfer
G7969_RS04110	COG0586	Pfam SNARE associated Golgi protein
G7969_RS04120	COG0728	peptidoglycan biosynthetic process
G7969_RS04125	COG0268	Binds directly to 16S ribosomal RNA
G7969_RS04135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G7969_RS04145	COG0137	argininosuccinate synthase activity
G7969_RS04150	COG3123	guanosine phosphorylase activity
G7969_RS04160	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G7969_RS04165	COG1666	GTP binding
G7969_RS04175	COG2366	antibiotic biosynthetic process
G7969_RS04180	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G7969_RS04190	COG4974	Belongs to the 'phage' integrase family
G7969_RS04205	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G7969_RS04210	COG0802	atpase or kinase
G7969_RS04215	COG0860	N-Acetylmuramoyl-L-alanine amidase
G7969_RS04225	COG0583	DNA-binding transcription factor activity
G7969_RS04245	COG0563	adenylate kinase activity
G7969_RS04250	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G7969_RS04255	COG2835	tetraacyldisaccharide 4'-kinase activity
G7969_RS04260	COG1663	tetraacyldisaccharide 4'-kinase activity
G7969_RS04270	COG0811	peptide transport
G7969_RS04275	COG1570	exodeoxyribonuclease VII activity
G7969_RS04280	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G7969_RS04325	COG2610	gluconate transmembrane transporter activity
G7969_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS04400	COG2321	neutral zinc metallopeptidase
G7969_RS04415	COG2259	Doxx family
G7969_RS04425	COG0583	DNA-binding transcription factor activity
G7969_RS04430	COG0583	DNA-binding transcription factor activity
G7969_RS04450	COG1858	cytochrome C peroxidase
G7969_RS04485	COG1278	Cold shock
G7969_RS04490	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G7969_RS04495	COG0542	response to heat
G7969_RS04500	COG0756	dUTP diphosphatase activity
G7969_RS04505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7969_RS04510	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G7969_RS04520	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G7969_RS04525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G7969_RS04530	COG0196	riboflavin kinase activity
G7969_RS04535	COG5002	protein histidine kinase activity
G7969_RS04535	COG0784	Response regulator, receiver
G7969_RS04540	COG2197	response regulator
G7969_RS04545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G7969_RS04550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G7969_RS04550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7969_RS04560	COG1511	domain protein
G7969_RS04560	COG3264	Mechanosensitive ion channel
G7969_RS04570	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G7969_RS04580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G7969_RS04585	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G7969_RS04590	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G7969_RS04595	COG2003	Belongs to the UPF0758 family
G7969_RS04600	COG1047	Peptidyl-prolyl cis-trans
G7969_RS04605	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G7969_RS04640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7969_RS04680	COG2084	Dehydrogenase
G7969_RS04690	COG0583	DNA-binding transcription factor activity
G7969_RS04700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7969_RS04710	COG0175	sulfate reduction
G7969_RS04720	COG2895	sulfate adenylyltransferase (ATP) activity
G7969_RS04725	COG1648	precorrin-2 dehydrogenase activity
G7969_RS04725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7969_RS04750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G7969_RS04765	COG0129	dihydroxy-acid dehydratase activity
G7969_RS04770	COG0583	DNA-binding transcription factor activity
G7969_RS04775	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G7969_RS04805	COG4206	TonB-dependent receptor
G7969_RS04815	COG1120	ATPase activity
G7969_RS04820	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G7969_RS04825	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G7969_RS04835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G7969_RS04845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G7969_RS04855	COG1492	cobalamin metabolic process
G7969_RS04875	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G7969_RS04880	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G7969_RS04895	COG2911	Protein conserved in bacteria
G7969_RS04905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7969_RS04905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7969_RS04910	COG2885	chlorophyll binding
G7969_RS04910	COG3047	cAMP biosynthetic process
G7969_RS04915	COG0489	protein tyrosine kinase activity
G7969_RS04945	COG3383	formate dehydrogenase (NAD+) activity
G7969_RS04945	COG0243	molybdopterin cofactor binding
G7969_RS04950	COG0437	4 iron, 4 sulfur cluster binding
G7969_RS04970	COG2032	superoxide dismutase activity
G7969_RS04975	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7969_RS04980	COG0717	Belongs to the dCTP deaminase family
G7969_RS04985	COG1982	Orn Lys Arg decarboxylase major
G7969_RS04995	COG0165	Argininosuccinate lyase
G7969_RS05020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G7969_RS05025	COG0181	hydroxymethylbilane synthase activity
G7969_RS05050	COG2271	Major facilitator Superfamily
G7969_RS05065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G7969_RS05105	COG0492	ferredoxin-NADP+ reductase activity
G7969_RS05110	COG1674	ftsk spoiiie
G7969_RS05115	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G7969_RS05125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7969_RS05130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G7969_RS05270	COG0697	spore germination
G7969_RS05275	COG0583	DNA-binding transcription factor activity
G7969_RS05280	COG0582	viral genome integration into host DNA
G7969_RS05290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G7969_RS05300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
G7969_RS05370	COG0582	viral genome integration into host DNA
G7969_RS05455	COG5377	YqaJ viral recombinase family
G7969_RS05505	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G7969_RS05510	COG3501	Rhs element vgr protein
G7969_RS05530	COG1846	Transcriptional regulator
G7969_RS05540	COG2814	Major facilitator Superfamily
G7969_RS05550	COG4221	oxidoreductase activity
G7969_RS05555	COG1522	sequence-specific DNA binding
G7969_RS05565	COG1522	sequence-specific DNA binding
G7969_RS05575	COG2814	Major facilitator Superfamily
G7969_RS05595	COG2197	response regulator
G7969_RS05650	COG2165	general secretion pathway protein
G7969_RS05720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7969_RS05770	COG1253	flavin adenine dinucleotide binding
G7969_RS05825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS05840	COG0765	amino acid transport
G7969_RS05845	COG0765	amino acid transport
G7969_RS05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7969_RS05860	COG1414	Transcriptional regulator
G7969_RS05870	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G7969_RS05875	COG0183	Belongs to the thiolase family
G7969_RS05885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7969_RS05890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7969_RS05905	COG0411	ABC transporter
G7969_RS05915	COG0683	leucine binding
G7969_RS05930	COG2342	PFAM TM1410 hypothetical-related protein
G7969_RS05940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G7969_RS05955	COG0525	valine-tRNA ligase activity
G7969_RS05960	COG0210	DNA helicase
G7969_RS05970	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G7969_RS05980	COG1611	Belongs to the LOG family
G7969_RS05985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7969_RS05985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G7969_RS05990	COG1252	NADH dehydrogenase
G7969_RS05995	COG0412	Dienelactone hydrolase
G7969_RS06005	COG3385	transposase activity
G7969_RS06025	COG1722	exodeoxyribonuclease VII activity
G7969_RS06030	COG0142	geranyltranstransferase activity
G7969_RS06035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G7969_RS06040	COG1469	GTP cyclohydrolase I activity
G7969_RS06045	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G7969_RS06050	COG2081	HI0933 family
G7969_RS06055	COG1610	YqeY-like protein
G7969_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7969_RS06085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7969_RS06085	COG0426	domain, Protein
G7969_RS06090	COG0513	Belongs to the DEAD box helicase family
G7969_RS06095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7969_RS06100	COG0583	DNA-binding transcription factor activity
G7969_RS06105	COG1741	Belongs to the pirin family
G7969_RS06145	COG1132	(ABC) transporter
G7969_RS06165	COG1530	ribonuclease E activity
G7969_RS06170	COG0424	maF-like protein
G7969_RS06175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G7969_RS06180	COG0799	negative regulation of ribosome biogenesis
G7969_RS06190	COG0408	coproporphyrinogen oxidase activity
G7969_RS06195	COG0151	Belongs to the GarS family
G7969_RS06200	COG0217	transcriptional regulatory protein
G7969_RS06205	COG0433	COG0433 Predicted ATPase
G7969_RS06210	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G7969_RS06215	COG0697	spore germination
G7969_RS06220	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS06225	COG1803	Methylglyoxal synthase
G7969_RS06280	COG1129	ABC transporter
G7969_RS06285	COG2814	Major facilitator Superfamily
G7969_RS06290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G7969_RS06295	COG1984	allophanate hydrolase subunit 2
G7969_RS06300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7969_RS06315	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G7969_RS06320	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G7969_RS06335	COG1234	tRNA 3'-trailer cleavage
G7969_RS06345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G7969_RS06350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G7969_RS06355	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G7969_RS06365	COG0515	serine threonine protein kinase
G7969_RS06365	COG3064	Membrane
G7969_RS06365	COG4991	sh3 domain protein
G7969_RS06370	COG1561	YicC-like family, N-terminal region
G7969_RS06375	COG0194	GDP metabolic process
G7969_RS06380	COG1758	RNA polymerase activity
G7969_RS06385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7969_RS06415	COG1652	LysM domain
G7969_RS06425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7969_RS06450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7969_RS06455	COG3842	ATPase activity
G7969_RS06495	COG0246	Mannitol dehydrogenase
G7969_RS06500	COG1070	Carbohydrate kinase
G7969_RS06505	COG2390	Transcriptional regulator
G7969_RS06515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G7969_RS06520	COG0308	aminopeptidase N
G7969_RS06530	COG0281	malic enzyme
G7969_RS06530	COG0280	phosphate acetyltransferase
G7969_RS06540	COG3195	allantoin biosynthetic process
G7969_RS06540	COG3648	Uricase
G7969_RS06555	COG2233	PERMEase
G7969_RS06565	COG2351	hydroxyisourate hydrolase activity
G7969_RS06580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS06585	COG2271	Major facilitator Superfamily
G7969_RS06590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7969_RS06595	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS06605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS06615	COG1126	abc transporter atp-binding protein
G7969_RS06620	COG0765	amino acid transport
G7969_RS06625	COG0765	amino acid transport
G7969_RS06635	COG2186	Transcriptional regulator
G7969_RS06650	COG2119	membrane
G7969_RS06655	COG0402	S-adenosylhomocysteine deaminase activity
G7969_RS06660	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G7969_RS06670	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G7969_RS06695	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G7969_RS06720	COG1309	transcriptional regulator
G7969_RS06730	COG0438	transferase activity, transferring glycosyl groups
G7969_RS06765	COG0028	Belongs to the TPP enzyme family
G7969_RS06775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G7969_RS06780	COG0688	phosphatidylethanolamine metabolic process
G7969_RS06785	COG1183	phosphatidylcholine synthase activity
G7969_RS06790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7969_RS06800	COG0683	leucine binding
G7969_RS06805	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G7969_RS06810	COG1185	polyribonucleotide nucleotidyltransferase activity
G7969_RS06825	COG0149	triose-phosphate isomerase activity
G7969_RS06830	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G7969_RS06840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7969_RS06845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7969_RS06850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7969_RS06855	COG0649	NAD binding
G7969_RS06870	COG1034	ATP synthesis coupled electron transport
G7969_RS06875	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G7969_RS06880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G7969_RS06890	COG0713	ATP synthesis coupled electron transport
G7969_RS06905	COG1007	ATP synthesis coupled electron transport
G7969_RS06925	COG1960	acyl-CoA dehydrogenase activity
G7969_RS06930	COG1960	acyl-CoA dehydrogenase activity
G7969_RS06935	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS06935	COG2030	dehydratase
G7969_RS06970	COG0829	nickel cation binding
G7969_RS06975	COG0831	urea catabolic process
G7969_RS06985	COG0832	Belongs to the urease beta subunit family
G7969_RS06990	COG0804	urea catabolic process
G7969_RS06995	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G7969_RS07000	COG0830	nickel cation binding
G7969_RS07005	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G7969_RS07035	COG0625	glutathione transferase activity
G7969_RS07040	COG1960	acyl-CoA dehydrogenase activity
G7969_RS07070	COG1024	Enoyl-CoA hydratase
G7969_RS07075	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7969_RS07080	COG0625	glutathione transferase activity
G7969_RS07085	COG0436	Aminotransferase
G7969_RS07095	COG3022	response to hydroperoxide
G7969_RS07100	COG2866	Carboxypeptidase
G7969_RS07110	COG0747	negative chemotaxis
G7969_RS07125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G7969_RS07150	COG0039	L-malate dehydrogenase activity
G7969_RS07155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS07165	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G7969_RS07170	COG1053	succinate dehydrogenase
G7969_RS07175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G7969_RS07180	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G7969_RS07185	COG0372	Belongs to the citrate synthase family
G7969_RS07190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G7969_RS07195	COG0066	3-isopropylmalate dehydratase activity
G7969_RS07200	COG0473	3-isopropylmalate dehydrogenase activity
G7969_RS07220	COG0101	tRNA pseudouridine synthase activity
G7969_RS07225	COG0135	phosphoribosylanthranilate isomerase activity
G7969_RS07230	COG0133	tryptophan synthase activity
G7969_RS07240	COG0159	tryptophan synthase activity
G7969_RS07245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G7969_RS07250	COG0285	dihydrofolate synthase activity
G7969_RS07270	COG0842	Transport permease protein
G7969_RS07275	COG1131	(ABC) transporter
G7969_RS07305	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G7969_RS07350	COG1301	dicarboxylic acid transport
G7969_RS07355	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G7969_RS07370	COG0697	spore germination
G7969_RS07375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7969_RS07380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G7969_RS07400	COG2197	response regulator
G7969_RS07405	COG0840	transmembrane signaling receptor activity
G7969_RS07445	COG0747	negative chemotaxis
G7969_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7969_RS07465	COG0601	transmembrane transport
G7969_RS07470	COG2072	flavoprotein involved in K transport
G7969_RS07515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G7969_RS07530	COG3039	Transposase
G7969_RS07565	COG0656	L-ascorbic acid biosynthetic process
G7969_RS07570	COG2304	oxidoreductase activity
G7969_RS07585	COG0589	response to stress
G7969_RS07620	COG0328	RNA-DNA hybrid ribonuclease activity
G7969_RS07625	COG2226	methyltransferase
G7969_RS07630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7969_RS07635	COG1388	LysM domain
G7969_RS07635	COG0741	lytic transglycosylase activity
G7969_RS07640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7969_RS07645	COG0505	Belongs to the CarA family
G7969_RS07655	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G7969_RS07660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G7969_RS07670	COG1534	Rna-binding protein
G7969_RS07675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G7969_RS07680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7969_RS07685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G7969_RS07690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G7969_RS07695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G7969_RS07700	COG0573	inorganic phosphate transmembrane transporter activity
G7969_RS07705	COG0581	inorganic phosphate transmembrane transporter activity
G7969_RS07710	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7969_RS07720	COG0745	RESPONSE REGULATOR receiver
G7969_RS07730	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G7969_RS07735	COG0248	Ppx GppA phosphatase
G7969_RS07765	COG0730	response to heat
G7969_RS07775	COG0640	Transcriptional regulator
G7969_RS07785	COG5001	Diguanylate cyclase
G7969_RS07785	COG3300	MHYT domain
G7969_RS07790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G7969_RS07835	COG0277	FAD linked oxidase domain protein
G7969_RS07850	COG1295	ribonuclease BN
G7969_RS07875	COG0477	Major facilitator Superfamily
G7969_RS07880	COG0545	Peptidyl-prolyl cis-trans isomerase
G7969_RS07885	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G7969_RS07895	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS07900	COG4566	intracellular signal transduction
G7969_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS07925	COG0251	oxidation-reduction process
G7969_RS07930	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G7969_RS07940	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G7969_RS07945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G7969_RS07950	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G7969_RS07955	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G7969_RS07960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G7969_RS07965	COG0072	phenylalanine-tRNA ligase activity
G7969_RS07965	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G7969_RS07970	COG0776	regulation of translation
G7969_RS08000	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G7969_RS08005	COG0531	amino acid
G7969_RS08025	COG1846	Transcriptional regulator
G7969_RS08035	COG0402	S-adenosylhomocysteine deaminase activity
G7969_RS08040	COG0339	signal peptide processing
G7969_RS08045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G7969_RS08050	COG4566	intracellular signal transduction
G7969_RS08065	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G7969_RS08070	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7969_RS08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7969_RS08095	COG0123	including yeast histone deacetylase and acetoin utilization protein
G7969_RS08120	COG1414	Transcriptional regulator
G7969_RS08150	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G7969_RS08155	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G7969_RS08175	COG0167	dihydroorotate dehydrogenase activity
G7969_RS08185	COG3158	transport of potassium into the cell
G7969_RS08195	COG2183	response to ionizing radiation
G7969_RS08210	COG1199	ATP-dependent helicase activity
G7969_RS08220	COG0564	pseudouridine synthase activity
G7969_RS08235	COG3243	poly(R)-hydroxyalkanoic acid synthase
G7969_RS08240	COG0183	Belongs to the thiolase family
G7969_RS08245	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS08255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7969_RS08260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7969_RS08265	COG0183	Belongs to the thiolase family
G7969_RS08280	COG0560	Phosphoserine phosphatase
G7969_RS08290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G7969_RS08295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G7969_RS08300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G7969_RS08305	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G7969_RS08310	COG0450	alkyl hydroperoxide reductase
G7969_RS08320	COG0745	RESPONSE REGULATOR receiver
G7969_RS08340	COG1562	ergosterol biosynthetic process
G7969_RS08345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS08365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS08365	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G7969_RS08370	COG0544	peptidyl-prolyl cis-trans isomerase activity
G7969_RS08375	COG0740	serine-type endopeptidase activity
G7969_RS08380	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G7969_RS08385	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G7969_RS08390	COG0776	regulation of translation
G7969_RS08405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS08410	COG3385	transposase activity
G7969_RS08425	COG4181	ATPase activity
G7969_RS08430	COG0166	Belongs to the GPI family
G7969_RS08435	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G7969_RS08445	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G7969_RS08445	COG0047	phosphoribosylformylglycinamidine synthase activity
G7969_RS08465	COG0535	radical SAM domain protein
G7969_RS08490	COG0583	DNA-binding transcription factor activity
G7969_RS08495	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS08505	COG1176	ABC-type spermidine putrescine transport system, permease component I
G7969_RS08515	COG3842	ATPase activity
G7969_RS08520	COG0642	Histidine kinase
G7969_RS08535	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G7969_RS08560	COG1126	abc transporter atp-binding protein
G7969_RS08565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS08575	COG2917	probably involved in intracellular septation
G7969_RS08580	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7969_RS08585	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G7969_RS08590	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS08600	COG0559	Belongs to the binding-protein-dependent transport system permease family
G7969_RS08630	COG0833	amino acid
G7969_RS08635	COG0833	amino acid
G7969_RS08645	COG1335	isochorismatase
G7969_RS08650	COG0183	Belongs to the thiolase family
G7969_RS08655	COG1960	acyl-CoA dehydrogenase activity
G7969_RS08660	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS08675	COG2130	NADP-dependent
G7969_RS08695	COG0596	Alpha beta hydrolase
G7969_RS08740	COG2831	hemolysin activation secretion protein
G7969_RS08760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G7969_RS08765	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G7969_RS08770	COG0470	DNA polymerase III
G7969_RS08780	COG0084	hydrolase, TatD family'
G7969_RS08790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G7969_RS08795	COG1609	Transcriptional regulator
G7969_RS08800	COG1840	ABC-type Fe3 transport system, periplasmic component
G7969_RS08810	COG4208	sulfate ABC transporter
G7969_RS08815	COG3842	ATPase activity
G7969_RS08820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7969_RS08825	COG3023	N-Acetylmuramoyl-L-alanine amidase
G7969_RS08860	COG0038	chloride channel
G7969_RS08865	COG2226	methyltransferase
G7969_RS08880	COG4771	TonB-dependent receptor
G7969_RS08900	COG2226	methyltransferase
G7969_RS08900	COG3433	isochorismatase activity
G7969_RS08900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G7969_RS08915	COG2201	protein-glutamate methylesterase activity
G7969_RS08920	COG0456	acetyltransferase
G7969_RS08965	COG0179	Fumarylacetoacetate (FAA) hydrolase
G7969_RS09010	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G7969_RS09085	COG2814	Major facilitator Superfamily
G7969_RS09105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS09115	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G7969_RS09160	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G7969_RS09165	COG0156	8-amino-7-oxononanoate synthase activity
G7969_RS09200	COG3045	CreA protein
G7969_RS09255	COG0840	transmembrane signaling receptor activity
G7969_RS09265	COG3387	PFAM Glycoside hydrolase 15-related
G7969_RS09290	COG0488	(ABC) transporter
G7969_RS09295	COG1619	proteins homologs of microcin C7 resistance protein MccF
G7969_RS09305	COG0720	synthase
G7969_RS09310	COG0602	queuosine metabolic process
G7969_RS09330	COG3550	peptidyl-serine autophosphorylation
G7969_RS09350	COG3485	protocatechuate 3,4-dioxygenase
G7969_RS09355	COG3485	protocatechuate 3,4-dioxygenase
G7969_RS09360	COG0583	DNA-binding transcription factor activity
G7969_RS09400	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7969_RS09400	COG0519	Catalyzes the synthesis of GMP from XMP
G7969_RS09415	COG0697	spore germination
G7969_RS09425	COG2914	Belongs to the UPF0125 (RnfH) family
G7969_RS09430	COG2867	negative regulation of translational initiation
G7969_RS09435	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G7969_RS09440	COG0330	HflC and HflK could
G7969_RS09455	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G7969_RS09460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7969_RS09465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G7969_RS09470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7969_RS09475	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7969_RS09480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7969_RS09485	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7969_RS09500	COG0750	zinc metalloprotease
G7969_RS09505	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G7969_RS09510	COG0575	Belongs to the CDS family
G7969_RS09515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G7969_RS09520	COG0233	cytoplasmic translational termination
G7969_RS09525	COG0528	UMP kinase activity
G7969_RS09530	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G7969_RS09535	COG0052	Belongs to the universal ribosomal protein uS2 family
G7969_RS09540	COG0024	Methionine aminopeptidase
G7969_RS09545	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G7969_RS09550	COG1187	pseudouridine synthase activity
G7969_RS09560	COG0242	peptide deformylase activity
G7969_RS09565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G7969_RS09580	COG0596	Alpha beta hydrolase
G7969_RS09595	COG2171	N-acyltransferase activity
G7969_RS09605	COG1393	Belongs to the ArsC family
G7969_RS09610	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7969_RS09620	COG2890	protein-(glutamine-N5) methyltransferase activity
G7969_RS09625	COG0302	gtp cyclohydrolase
G7969_RS09650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G7969_RS09655	COG0601	transmembrane transport
G7969_RS09660	COG0747	negative chemotaxis
G7969_RS09665	COG4172	Belongs to the ABC transporter superfamily
G7969_RS09680	COG0488	(ABC) transporter
G7969_RS09685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7969_RS09690	COG1683	Conserved Protein
G7969_RS09695	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7969_RS09705	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G7969_RS09710	COG0477	Major facilitator Superfamily
G7969_RS09715	COG1573	uracil-dna glycosylase
G7969_RS09725	COG1214	PFAM Peptidase M22, glycoprotease
G7969_RS09735	COG2814	Major facilitator Superfamily
G7969_RS09745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G7969_RS09755	COG0583	DNA-binding transcription factor activity
G7969_RS09765	COG2224	Isocitrate lyase
G7969_RS09790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7969_RS09820	COG0583	DNA-binding transcription factor activity
G7969_RS09825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G7969_RS09830	COG4208	sulfate ABC transporter
G7969_RS09855	COG1116	anion transmembrane transporter activity
G7969_RS09860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7969_RS09865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7969_RS09870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7969_RS09875	COG0431	NADPH-dependent FMN reductase
G7969_RS09880	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G7969_RS09885	COG0542	response to heat
G7969_RS09895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G7969_RS09900	COG0314	molybdopterin synthase activity
G7969_RS09905	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G7969_RS09910	COG0303	'Molybdopterin
G7969_RS09915	COG1573	uracil-dna glycosylase
G7969_RS09930	COG0436	Aminotransferase
G7969_RS09940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G7969_RS09945	COG2076	Multidrug Resistance protein
G7969_RS09950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G7969_RS09965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7969_RS09965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7969_RS09975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G7969_RS09980	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G7969_RS09990	COG0791	NLP P60 protein
G7969_RS09995	COG0306	phosphate transporter
G7969_RS10005	COG0305	Participates in initiation and elongation during chromosome replication
G7969_RS10010	COG0359	binds to the 23S rRNA
G7969_RS10015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G7969_RS10025	COG0360	Binds together with S18 to 16S ribosomal RNA
G7969_RS10040	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G7969_RS10055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7969_RS10070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G7969_RS10075	COG1024	Enoyl-CoA hydratase
G7969_RS10100	COG1566	PFAM secretion protein HlyD family protein
G7969_RS10105	COG2814	Major facilitator Superfamily
G7969_RS10110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G7969_RS10115	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G7969_RS10120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G7969_RS10125	COG2251	uridine kinase activity
G7969_RS10125	COG0195	Participates in both transcription termination and antitermination
G7969_RS10130	COG0779	Required for maturation of 30S ribosomal subunits
G7969_RS10135	COG1187	pseudouridine synthase activity
G7969_RS10140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G7969_RS10150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7969_RS10185	COG3278	Belongs to the heme-copper respiratory oxidase family
G7969_RS10195	COG2217	Heavy metal translocating P-type atpase
G7969_RS10205	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G7969_RS10210	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G7969_RS10215	COG0508	dehydrogenase complex catalyzes the overall conversion of
G7969_RS10220	COG0567	Dehydrogenase, E1 component
G7969_RS10225	COG0584	glycerophosphoryl diester phosphodiesterase
G7969_RS10230	COG3842	ATPase activity
G7969_RS10240	COG1175	transmembrane transport
G7969_RS10245	COG1653	transport
G7969_RS10260	COG2204	response regulator
G7969_RS10275	COG0174	glutamine synthetase
G7969_RS10285	COG1058	Belongs to the CinA family
G7969_RS10285	COG1546	Belongs to the CinA family
G7969_RS10310	COG1643	Atp-dependent helicase
G7969_RS10315	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G7969_RS10315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7969_RS10320	COG1737	Transcriptional regulator
G7969_RS10325	COG0673	inositol 2-dehydrogenase activity
G7969_RS10335	COG0673	inositol 2-dehydrogenase activity
G7969_RS10345	COG1082	Xylose isomerase domain protein TIM barrel
G7969_RS10350	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7969_RS10355	COG1129	ABC transporter
G7969_RS10365	COG3039	Transposase
G7969_RS10370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7969_RS10375	COG3962	Belongs to the TPP enzyme family
G7969_RS10385	COG3718	enzyme involved in inositol metabolism
G7969_RS10395	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G7969_RS10405	COG1953	Uracil, thiamine, allantoin
G7969_RS10410	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
G7969_RS10415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G7969_RS10420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G7969_RS10425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G7969_RS10430	COG0557	exoribonuclease II activity
G7969_RS10440	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G7969_RS10445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G7969_RS10450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G7969_RS10460	COG0330	HflC and HflK could
G7969_RS10465	COG0330	HflC and HflK could
G7969_RS10470	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G7969_RS10475	COG1923	regulation of RNA biosynthetic process
G7969_RS10480	COG1160	GTP binding
G7969_RS10490	COG2976	Protein conserved in bacteria
G7969_RS10495	COG0124	histidyl-tRNA synthetase
G7969_RS10500	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G7969_RS10515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G7969_RS10520	COG0105	UTP biosynthetic process
G7969_RS10530	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G7969_RS10550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7969_RS10555	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G7969_RS10560	COG0604	alcohol dehydrogenase
G7969_RS10560	COG3321	synthase
G7969_RS10560	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS10565	COG1902	pentaerythritol trinitrate reductase activity
G7969_RS10570	COG1309	transcriptional regulator
G7969_RS10575	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7969_RS10585	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7969_RS10590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7969_RS10605	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G7969_RS10610	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G7969_RS10615	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G7969_RS10625	COG1074	ATP-dependent DNA helicase activity
G7969_RS10640	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G7969_RS10645	COG2204	response regulator
G7969_RS10650	COG2197	response regulator
G7969_RS10655	COG3228	Belongs to the MtfA family
G7969_RS10665	COG0254	rRNA binding
G7969_RS10675	COG0534	Mate efflux family protein
G7969_RS10710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7969_RS10715	COG1752	Esterase of the alpha-beta hydrolase superfamily
G7969_RS10720	COG3385	transposase activity
G7969_RS10725	COG0791	NLP P60 protein
G7969_RS10730	COG4172	Belongs to the ABC transporter superfamily
G7969_RS10735	COG4239	(ABC) transporter, permease
G7969_RS10740	COG4174	ABC transporter (Permease)
G7969_RS10745	COG4166	transmembrane transport
G7969_RS10760	COG0527	aspartate kinase activity
G7969_RS10765	COG0037	tRNA processing
G7969_RS10770	COG0825	malonyl-CoA metabolic process
G7969_RS10775	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G7969_RS10780	COG0215	cysteine-tRNA ligase activity
G7969_RS10795	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G7969_RS10800	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G7969_RS10805	COG1045	serine acetyltransferase
G7969_RS10820	COG1396	sequence-specific DNA binding
G7969_RS10830	COG2258	MOSC domain
G7969_RS10840	COG0840	transmembrane signaling receptor activity
G7969_RS10850	COG2814	Major facilitator Superfamily
G7969_RS10855	COG0583	DNA-binding transcription factor activity
G7969_RS10870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G7969_RS10885	COG2850	peptidyl-arginine hydroxylation
G7969_RS10895	COG1234	tRNA 3'-trailer cleavage
G7969_RS10900	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G7969_RS10905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7969_RS10915	COG0180	Tryptophanyl-tRNA synthetase
G7969_RS10920	COG1994	Peptidase M50
G7969_RS10925	COG0009	L-threonylcarbamoyladenylate synthase
G7969_RS10930	COG0613	PHP domain protein
G7969_RS10935	COG0492	ferredoxin-NADP+ reductase activity
G7969_RS10950	COG3011	Protein conserved in bacteria
G7969_RS10955	COG2267	carboxylic ester hydrolase activity
G7969_RS10960	COG2833	Protein of unknown function (DUF455)
G7969_RS10970	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G7969_RS10980	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G7969_RS10985	COG0148	phosphopyruvate hydratase activity
G7969_RS10995	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G7969_RS11000	COG0504	CTP synthase activity
G7969_RS11005	COG2267	carboxylic ester hydrolase activity
G7969_RS11025	COG2308	Evidence 4 Homologs of previously reported genes of
G7969_RS11035	COG0084	hydrolase, TatD family'
G7969_RS11040	COG1136	(ABC) transporter
G7969_RS11055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G7969_RS11060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G7969_RS11085	COG2855	membrane
G7969_RS11090	COG0583	DNA-binding transcription factor activity
G7969_RS11130	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7969_RS11130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G7969_RS11165	COG0436	Aminotransferase
G7969_RS11175	COG0583	DNA-binding transcription factor activity
G7969_RS11180	COG2271	Major facilitator Superfamily
G7969_RS11220	COG0625	glutathione transferase activity
G7969_RS11225	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS11235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS11245	COG2271	Major facilitator Superfamily
G7969_RS11255	COG2186	Transcriptional regulator
G7969_RS11260	COG3385	transposase activity
G7969_RS11270	COG0745	RESPONSE REGULATOR receiver
G7969_RS11275	COG5002	protein histidine kinase activity
G7969_RS11285	COG0745	RESPONSE REGULATOR receiver
G7969_RS11310	COG0322	excinuclease ABC activity
G7969_RS11320	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G7969_RS11330	COG0736	holo-[acyl-carrier-protein] synthase activity
G7969_RS11335	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G7969_RS11340	COG1381	Involved in DNA repair and RecF pathway recombination
G7969_RS11345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G7969_RS11350	COG0571	ribonuclease III activity
G7969_RS11360	COG0681	Belongs to the peptidase S26 family
G7969_RS11365	COG0481	GTPase activity
G7969_RS11375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7969_RS11400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7969_RS11405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7969_RS11410	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS11420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G7969_RS11425	COG0416	fatty acid biosynthetic process
G7969_RS11430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G7969_RS11435	COG1399	metal-binding, possibly nucleic acid-binding protein
G7969_RS11440	COG0424	maF-like protein
G7969_RS11450	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G7969_RS11450	COG0616	signal peptide processing
G7969_RS11460	COG0546	phosphoglycolate phosphatase activity
G7969_RS11470	COG1530	ribonuclease E activity
G7969_RS11475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G7969_RS11480	COG0746	molybdenum cofactor guanylyltransferase activity
G7969_RS11495	COG1322	Protein conserved in bacteria
G7969_RS11500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7969_RS11515	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G7969_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS11530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G7969_RS11540	COG3385	transposase activity
G7969_RS11555	COG0443	Heat shock 70 kDa protein
G7969_RS11560	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G7969_RS11570	COG0316	Belongs to the HesB IscA family
G7969_RS11575	COG0822	iron-sulfur transferase activity
G7969_RS11580	COG1104	cysteine desulfurase activity
G7969_RS11590	COG1879	ABC-type sugar transport system periplasmic component
G7969_RS11600	COG1172	Belongs to the binding-protein-dependent transport system permease family
G7969_RS11605	COG1609	Transcriptional regulator
G7969_RS11610	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G7969_RS11620	COG0556	nucleotide-excision repair
G7969_RS11635	COG1309	transcriptional regulator
G7969_RS11640	COG2878	Part of a membrane complex involved in electron transport
G7969_RS11645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G7969_RS11650	COG0778	Nitroreductase
G7969_RS11685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G7969_RS11725	COG0326	Molecular chaperone. Has ATPase activity
G7969_RS11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS11735	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7969_RS11740	COG0697	spore germination
G7969_RS11750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS11755	COG0625	glutathione transferase activity
G7969_RS11770	COG1620	l-lactate permease
G7969_RS11790	COG0741	lytic transglycosylase activity
G7969_RS11840	COG0513	Belongs to the DEAD box helicase family
G7969_RS11845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G7969_RS11855	COG0861	Integral membrane protein TerC family
G7969_RS11865	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G7969_RS11875	COG0312	modulator of DNA gyrase
G7969_RS11880	COG3028	Belongs to the UPF0307 family
G7969_RS11885	COG0521	Mo-molybdopterin cofactor biosynthetic process
G7969_RS11890	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G7969_RS11895	COG0501	Belongs to the peptidase M48B family
G7969_RS11900	COG1162	GTPase activity
G7969_RS11910	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G7969_RS11915	COG0494	nUDIX hydrolase
G7969_RS11920	COG0335	large ribosomal subunit rRNA binding
G7969_RS11925	COG0336	Belongs to the RNA methyltransferase TrmD family
G7969_RS11930	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G7969_RS11935	COG0228	four-way junction DNA binding
G7969_RS11970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS11975	COG1960	acyl-CoA dehydrogenase activity
G7969_RS11995	COG2011	ABC-type metal ion transport system permease component
G7969_RS12000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G7969_RS12005	COG0123	including yeast histone deacetylase and acetoin utilization protein
G7969_RS12010	COG2951	lytic endotransglycosylase activity
G7969_RS12025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7969_RS12030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G7969_RS12040	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G7969_RS12050	COG0776	regulation of translation
G7969_RS12060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G7969_RS12065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G7969_RS12070	COG0287	Prephenate dehydrogenase
G7969_RS12075	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G7969_RS12080	COG0077	Prephenate dehydratase
G7969_RS12080	COG1605	Chorismate mutase
G7969_RS12085	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G7969_RS12110	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G7969_RS12175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS12185	COG3210	domain, Protein
G7969_RS12265	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
G7969_RS12300	COG4221	oxidoreductase activity
G7969_RS12435	COG3311	Transcriptional regulator
G7969_RS12450	COG0464	growth
G7969_RS12560	COG3501	Rhs element vgr protein
G7969_RS12580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7969_RS12615	COG3385	transposase activity
G7969_RS12695	COG3039	Transposase
G7969_RS12705	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7969_RS12725	COG4974	Belongs to the 'phage' integrase family
G7969_RS12730	COG0582	viral genome integration into host DNA
G7969_RS12735	COG4974	Belongs to the 'phage' integrase family
G7969_RS12830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G7969_RS12840	COG3039	Transposase
G7969_RS12915	COG3621	Patatin-like phospholipase
G7969_RS12925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G7969_RS12980	COG0402	S-adenosylhomocysteine deaminase activity
G7969_RS13080	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7969_RS13100	COG4974	Belongs to the 'phage' integrase family
G7969_RS13105	COG0582	viral genome integration into host DNA
G7969_RS13110	COG4974	Belongs to the 'phage' integrase family
G7969_RS13200	COG2189	Belongs to the N(4) N(6)-methyltransferase family
G7969_RS13255	COG1309	transcriptional regulator
G7969_RS13260	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS13265	COG0604	alcohol dehydrogenase
G7969_RS13310	COG2963	transposase activity
G7969_RS13330	COG0778	Nitroreductase
G7969_RS13345	COG4305	rare lipoprotein A
G7969_RS13375	COG1280	lysine exporter protein (LysE YggA)
G7969_RS13390	COG0425	Belongs to the sulfur carrier protein TusA family
G7969_RS13405	COG1942	4-Oxalocrotonate Tautomerase
G7969_RS13410	COG0235	Class ii aldolase
G7969_RS13415	COG0477	Major facilitator Superfamily
G7969_RS13430	COG0330	HflC and HflK could
G7969_RS13455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G7969_RS13460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7969_RS13485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G7969_RS13515	COG4681	YaeQ
G7969_RS13530	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G7969_RS13540	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS13545	COG3118	belongs to the thioredoxin family
G7969_RS13555	COG2703	oxygen carrier activity
G7969_RS13560	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G7969_RS13565	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G7969_RS13570	COG2982	Protein involved in outer membrane biogenesis
G7969_RS13595	COG0259	pyridoxamine-phosphate oxidase activity
G7969_RS13600	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G7969_RS13610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G7969_RS13615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G7969_RS13625	COG1522	sequence-specific DNA binding
G7969_RS13630	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G7969_RS13640	COG3483	tryptophan 2,3-dioxygenase activity
G7969_RS13650	COG1960	acyl-CoA dehydrogenase activity
G7969_RS13655	COG2252	PERMEase
G7969_RS13660	COG0450	alkyl hydroperoxide reductase
G7969_RS13665	COG4575	ribosome binding
G7969_RS13685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G7969_RS13690	COG0390	transport system, permease component
G7969_RS13695	COG0494	nUDIX hydrolase
G7969_RS13700	COG2175	clavaminate synthase activity
G7969_RS13715	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G7969_RS13720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G7969_RS13725	COG0745	RESPONSE REGULATOR receiver
G7969_RS13740	COG2391	methyltransferase activity
G7969_RS13745	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G7969_RS13760	COG0823	Involved in the tonB-independent uptake of proteins
G7969_RS13780	COG0824	Thioesterase
G7969_RS13785	COG4221	oxidoreductase activity
G7969_RS13790	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G7969_RS13795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G7969_RS13860	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7969_RS13860	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G7969_RS13875	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G7969_RS13880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G7969_RS13895	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G7969_RS13925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G7969_RS13930	COG1902	pentaerythritol trinitrate reductase activity
G7969_RS13935	COG1968	undecaprenyl-diphosphatase activity
G7969_RS13955	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G7969_RS13960	COG0425	Belongs to the sulfur carrier protein TusA family
G7969_RS13960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7969_RS13980	COG0859	PFAM glycosyl transferase family 9
G7969_RS13995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G7969_RS14035	COG1088	dTDP-glucose 4,6-dehydratase activity
G7969_RS14040	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G7969_RS14055	COG0540	Belongs to the ATCase OTCase family
G7969_RS14060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G7969_RS14065	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G7969_RS14070	COG1678	Uncharacterized ACR, COG1678
G7969_RS14075	COG1187	pseudouridine synthase activity
G7969_RS14085	COG2198	Histidine kinase
G7969_RS14085	COG0643	Histidine kinase
G7969_RS14085	COG0784	Response regulator, receiver
G7969_RS14090	COG0840	transmembrane signaling receptor activity
G7969_RS14110	COG1773	rubredoxin
G7969_RS14115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G7969_RS14120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7969_RS14125	COG1704	LemA family
G7969_RS14170	COG4964	Belongs to the GSP D family
G7969_RS14260	COG4269	membrane
G7969_RS14265	COG0459	protein refolding
G7969_RS14270	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G7969_RS14275	COG0443	Heat shock 70 kDa protein
G7969_RS14290	COG1309	transcriptional regulator
G7969_RS14300	COG0583	DNA-binding transcription factor activity
G7969_RS14310	COG1064	alcohol dehydrogenase
G7969_RS14325	COG3039	Transposase
G7969_RS14330	COG4654	Cytochrome c, class I
G7969_RS14350	COG2207	Transcriptional regulator
G7969_RS14355	COG1063	alcohol dehydrogenase
G7969_RS14370	COG0513	Belongs to the DEAD box helicase family
G7969_RS14385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G7969_RS14390	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
G7969_RS14395	COG2974	May be involved in recombination
G7969_RS14420	COG0697	spore germination
G7969_RS14460	COG0840	transmembrane signaling receptor activity
G7969_RS14465	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G7969_RS14485	COG2995	paraquat-inducible protein a
G7969_RS14490	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G7969_RS14490	COG3008	intermembrane lipid transfer
G7969_RS14575	COG0738	Major facilitator superfamily
G7969_RS14580	COG2027	D-alanyl-D-alanine carboxypeptidase
G7969_RS14585	COG1763	Mo-molybdopterin cofactor biosynthetic process
G7969_RS14595	COG0546	phosphoglycolate phosphatase activity
G7969_RS14605	COG0009	L-threonylcarbamoyladenylate synthase
G7969_RS14610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G7969_RS14615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G7969_RS14620	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G7969_RS14630	COG0469	pyruvate kinase activity
G7969_RS14635	COG0126	phosphoglycerate kinase activity
G7969_RS14665	COG0859	PFAM glycosyl transferase family 9
G7969_RS14675	COG0429	hydrolase of the alpha beta-hydrolase fold
G7969_RS14685	COG4783	chaperone-mediated protein folding
G7969_RS14690	COG0315	cyclic pyranopterin monophosphate synthase activity
G7969_RS14700	COG4969	Belongs to the N-Me-Phe pilin family
G7969_RS14710	COG0861	Integral membrane protein TerC family
G7969_RS14720	COG0045	succinate-CoA ligase (ADP-forming) activity
G7969_RS14730	COG2137	regulation of response to DNA damage stimulus
G7969_RS14735	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G7969_RS14745	COG0642	Histidine kinase
G7969_RS14755	COG0477	Major facilitator Superfamily
G7969_RS14800	COG0513	Belongs to the DEAD box helicase family
G7969_RS14825	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS14860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G7969_RS14865	COG1702	phosphate starvation-inducible protein PhoH
G7969_RS14870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G7969_RS14875	COG4535	Mg2 and Co2 transporter CorC
G7969_RS14880	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G7969_RS14885	COG0752	glycyl-tRNA synthetase alpha subunit
G7969_RS14895	COG0751	glycine-tRNA ligase activity
G7969_RS14900	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G7969_RS14905	COG0204	Acyl-transferase
G7969_RS14915	COG0346	lactoylglutathione lyase activity
G7969_RS14920	COG0697	spore germination
G7969_RS14925	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G7969_RS14930	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G7969_RS14935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS14940	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G7969_RS14960	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G7969_RS14970	COG0006	proline dipeptidase activity
G7969_RS14975	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7969_RS14985	COG4680	protein conserved in bacteria
G7969_RS15000	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G7969_RS15005	COG0138	bifunctional purine biosynthesis protein purh
G7969_RS15010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G7969_RS15020	COG0632	four-way junction helicase activity
G7969_RS15025	COG2255	four-way junction helicase activity
G7969_RS15040	COG1490	D-aminoacyl-tRNA deacylase activity
G7969_RS15045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G7969_RS15050	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G7969_RS15055	COG0316	Belongs to the HesB IscA family
G7969_RS15070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G7969_RS15075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G7969_RS15095	COG0418	dihydroorotase activity
G7969_RS15105	COG0473	3-isopropylmalate dehydrogenase activity
G7969_RS15110	COG0121	glutamine amidotransferase
G7969_RS15115	COG1126	abc transporter atp-binding protein
G7969_RS15120	COG0765	amino acid transport
G7969_RS15125	COG0765	amino acid transport
G7969_RS15135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G7969_RS15145	COG5265	(ABC) transporter
G7969_RS15155	COG1024	Enoyl-CoA hydratase
G7969_RS15160	COG0183	Belongs to the thiolase family
G7969_RS15165	COG1024	Enoyl-CoA hydratase
G7969_RS15165	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7969_RS15170	COG1960	acyl-CoA dehydrogenase activity
G7969_RS15185	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7969_RS15190	COG3568	Endonuclease Exonuclease Phosphatase
G7969_RS15195	COG0494	nUDIX hydrolase
G7969_RS15205	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G7969_RS15230	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G7969_RS15245	COG2226	methyltransferase
G7969_RS15255	COG4178	(ABC) transporter
G7969_RS15270	COG1238	metal cluster binding
G7969_RS15275	COG0700	Nucleoside recognition
G7969_RS15290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G7969_RS15295	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7969_RS15295	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G7969_RS15325	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS15330	COG3265	gluconokinase activity
G7969_RS15345	COG2391	methyltransferase activity
G7969_RS15360	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS15375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G7969_RS15400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7969_RS15555	COG4974	Belongs to the 'phage' integrase family
G7969_RS15575	COG0629	single-stranded DNA binding
G7969_RS15580	COG2814	Major facilitator Superfamily
G7969_RS15595	COG1280	lysine exporter protein (LysE YggA)
G7969_RS15600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G7969_RS15605	COG0693	protein deglycase activity
G7969_RS15625	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G7969_RS15640	COG1137	ATPase activity
G7969_RS15645	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7969_RS15650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G7969_RS15660	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G7969_RS15665	COG3039	Transposase
G7969_RS15675	COG1660	Displays ATPase and GTPase activities
G7969_RS15685	COG1194	a g-specific adenine glycosylase
G7969_RS15695	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G7969_RS15705	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G7969_RS15710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G7969_RS15720	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7969_RS15725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G7969_RS15730	COG0193	aminoacyl-tRNA hydrolase activity
G7969_RS15740	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G7969_RS15745	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G7969_RS15750	COG0742	ribosomal rna small subunit methyltransferase
G7969_RS15755	COG0612	Peptidase, M16
G7969_RS15760	COG0612	Peptidase, M16
G7969_RS15775	COG0625	glutathione transferase activity
G7969_RS15785	COG3707	response regulator
G7969_RS15790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7969_RS15795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7969_RS15800	COG1116	anion transmembrane transporter activity
G7969_RS15805	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7969_RS15810	COG1741	Belongs to the pirin family
G7969_RS15820	COG3300	MHYT domain
G7969_RS15820	COG5001	Diguanylate cyclase
G7969_RS15825	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G7969_RS15830	COG1999	signal sequence binding
G7969_RS15835	COG0109	protoheme IX farnesyltransferase activity
G7969_RS15840	COG1612	heme a metabolic process
G7969_RS15870	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G7969_RS15875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G7969_RS15890	COG2226	methyltransferase
G7969_RS15895	COG1040	competence protein
G7969_RS15905	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G7969_RS15910	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G7969_RS15915	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G7969_RS15920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G7969_RS15925	COG0588	phosphoglycerate mutase activity
G7969_RS15930	COG0793	Belongs to the peptidase S41A family
G7969_RS15950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G7969_RS15955	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G7969_RS15965	COG0189	ligase activity
G7969_RS15975	COG0004	ammonium transporteR
G7969_RS16000	COG0606	chelatase, subunit chli
G7969_RS16020	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G7969_RS16030	COG2204	response regulator
G7969_RS16040	COG1301	dicarboxylic acid transport
G7969_RS16045	COG3411	Ferredoxin
G7969_RS16055	COG1686	Belongs to the peptidase S11 family
G7969_RS16060	COG2921	Belongs to the UPF0250 family
G7969_RS16065	COG0583	DNA-binding transcription factor activity
G7969_RS16075	COG0321	lipoyl(octanoyl) transferase activity
G7969_RS16080	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G7969_RS16095	COG3511	phospholipase C
G7969_RS16125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G7969_RS16130	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G7969_RS16130	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G7969_RS16135	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G7969_RS16145	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G7969_RS16170	COG1024	Enoyl-CoA hydratase
G7969_RS16200	COG2267	carboxylic ester hydrolase activity
G7969_RS16220	COG1410	methionine synthase
G7969_RS16220	COG0646	methionine synthase
G7969_RS16230	COG2197	response regulator
G7969_RS16260	COG0018	arginyl-trna synthetase
G7969_RS16270	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G7969_RS16275	COG4221	oxidoreductase activity
G7969_RS16285	COG2329	Antibiotic biosynthesis monooxygenase
G7969_RS16295	COG0789	Transcriptional regulator
G7969_RS16300	COG1960	acyl-CoA dehydrogenase activity
G7969_RS16305	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G7969_RS16310	COG0288	reversible hydration of carbon dioxide
G7969_RS16315	COG0183	Belongs to the thiolase family
G7969_RS16320	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS16325	COG1960	acyl-CoA dehydrogenase activity
G7969_RS16340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G7969_RS16345	COG3012	SEC-C Motif Domain Protein
G7969_RS16350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G7969_RS16360	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G7969_RS16365	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G7969_RS16370	COG4770	biotin carboxylase activity
G7969_RS16385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7969_RS16405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7969_RS16415	COG0596	Alpha beta hydrolase
G7969_RS16480	COG1250	3-hydroxyacyl-CoA dehydrogenase
G7969_RS16485	COG0583	DNA-binding transcription factor activity
G7969_RS16515	COG1703	isobutyryl-CoA mutase activity
G7969_RS16515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7969_RS16515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G7969_RS16555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G7969_RS16570	COG0430	RNA-3'-phosphate cyclase activity
G7969_RS16575	COG3541	Predicted nucleotidyltransferase
G7969_RS16580	COG1690	Belongs to the RtcB family
G7969_RS16590	COG4650	regulator
G7969_RS16605	COG1254	Belongs to the acylphosphatase family
G7969_RS16620	COG0667	Aldo Keto reductase
G7969_RS16625	COG2814	Major facilitator Superfamily
G7969_RS16630	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS16635	COG0583	DNA-binding transcription factor activity
G7969_RS16640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G7969_RS16640	COG0519	Catalyzes the synthesis of GMP from XMP
G7969_RS16655	COG1733	regulation of RNA biosynthetic process
G7969_RS16690	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
G7969_RS16700	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G7969_RS16705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
G7969_RS16710	COG0071	Belongs to the small heat shock protein (HSP20) family
G7969_RS16720	COG3038	cytochrome b561
G7969_RS16740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G7969_RS16745	COG1063	alcohol dehydrogenase
G7969_RS16755	COG2197	response regulator
G7969_RS16760	COG3851	Histidine kinase
G7969_RS16765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G7969_RS16795	COG0589	response to stress
G7969_RS16800	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G7969_RS16820	COG0589	response to stress
G7969_RS16845	COG3039	Transposase
G7969_RS16905	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G7969_RS16910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G7969_RS16920	COG0037	tRNA processing
G7969_RS16925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G7969_RS16930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G7969_RS16930	COG0546	phosphoglycolate phosphatase activity
G7969_RS16955	COG0493	'glutamate synthase
G7969_RS16970	COG0842	Transport permease protein
G7969_RS16975	COG1131	(ABC) transporter
G7969_RS16990	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS16995	COG0583	DNA-binding transcription factor activity
G7969_RS17000	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G7969_RS17015	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS17025	COG2223	nitrite transmembrane transporter activity
G7969_RS17040	COG0697	spore germination
G7969_RS17065	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G7969_RS17085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G7969_RS17090	COG4682	membrane
G7969_RS17095	COG0708	Exodeoxyribonuclease III
G7969_RS17100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G7969_RS17105	COG2326	polyphosphate kinase activity
G7969_RS17110	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G7969_RS17115	COG1560	Kdo2-lipid A biosynthetic process
G7969_RS17125	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G7969_RS17145	COG0517	IMP dehydrogenase activity
G7969_RS17155	COG1522	sequence-specific DNA binding
G7969_RS17190	COG1960	acyl-CoA dehydrogenase activity
G7969_RS17225	COG2070	2-Nitropropane dioxygenase
G7969_RS17230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G7969_RS17245	COG2022	thiamine diphosphate biosynthetic process
G7969_RS17255	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G7969_RS17305	COG0351	phosphomethylpyrimidine kinase
G7969_RS17315	COG1785	Belongs to the alkaline phosphatase family
G7969_RS17320	COG1785	Belongs to the alkaline phosphatase family
G7969_RS17335	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G7969_RS17340	COG1950	PFAM Membrane protein of
G7969_RS17345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G7969_RS17355	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G7969_RS17375	COG0617	tRNA 3'-terminal CCA addition
G7969_RS17385	COG3246	L-lysine catabolic process to acetate
G7969_RS17390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G7969_RS17415	COG2204	response regulator
G7969_RS17420	COG5000	phosphorelay sensor kinase activity
G7969_RS17435	COG0501	Belongs to the peptidase M48B family
G7969_RS17445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G7969_RS17455	COG0242	peptide deformylase activity
G7969_RS17460	COG1652	LysM domain
G7969_RS17465	COG0758	DNA mediated transformation
G7969_RS17480	COG0583	DNA-binding transcription factor activity
G7969_RS17485	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS17490	COG0772	Belongs to the SEDS family
G7969_RS17495	COG0768	penicillin binding
G7969_RS17505	COG1792	Involved in formation and maintenance of cell shape
G7969_RS17510	COG1077	Cell shape determining protein MreB Mrl
G7969_RS17515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7969_RS17520	COG0154	amidase activity
G7969_RS17535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G7969_RS17545	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G7969_RS17550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G7969_RS17570	COG0523	cobalamin synthesis protein
G7969_RS17585	COG0747	negative chemotaxis
G7969_RS17590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G7969_RS17595	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G7969_RS17605	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G7969_RS17635	COG1595	DNA-templated transcription, initiation
G7969_RS17640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G7969_RS17675	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G7969_RS17685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G7969_RS17695	COG3385	transposase activity
G7969_RS17710	COG2879	small protein
G7969_RS17715	COG1966	Carbon starvation protein
G7969_RS17730	COG3622	Belongs to the hyi family
G7969_RS17740	COG0745	RESPONSE REGULATOR receiver
G7969_RS17745	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G7969_RS17750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G7969_RS17755	COG3384	dioxygenase
G7969_RS17770	COG1309	transcriptional regulator
G7969_RS17775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS17780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7969_RS17790	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G7969_RS17805	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G7969_RS17810	COG0706	membrane insertase activity
G7969_RS17815	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G7969_RS17820	COG0594	ribonuclease P activity
G7969_RS17825	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G7969_RS17835	COG1278	Cold shock
G7969_RS17860	COG0477	Major facilitator Superfamily
G7969_RS17865	COG4191	Histidine kinase
G7969_RS17875	COG4377	Putative membrane peptidase family (DUF2324)
G7969_RS17885	COG3447	MASE1 domain protein
G7969_RS17885	COG5001	Diguanylate cyclase
G7969_RS17885	COG5002	protein histidine kinase activity
G7969_RS17925	COG0038	chloride channel
G7969_RS17940	COG1881	PFAM PEBP family protein
G7969_RS18015	COG0582	viral genome integration into host DNA
G7969_RS18030	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7969_RS18050	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS18060	COG1024	Enoyl-CoA hydratase
G7969_RS18065	COG1960	acyl-CoA dehydrogenase activity
G7969_RS18125	COG0477	Major facilitator Superfamily
G7969_RS18130	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G7969_RS18140	COG2814	Major facilitator Superfamily
G7969_RS18205	COG0725	ABC transporter, periplasmic molybdate-binding protein
G7969_RS18220	COG0714	Associated with various cellular activities
G7969_RS18235	COG0288	reversible hydration of carbon dioxide
G7969_RS18285	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G7969_RS18295	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G7969_RS18300	COG2944	sequence-specific DNA binding
G7969_RS18315	COG0210	DNA helicase
G7969_RS18340	COG0697	spore germination
G7969_RS18355	COG1902	pentaerythritol trinitrate reductase activity
G7969_RS18355	COG0446	pyridine nucleotide-disulphide oxidoreductase
G7969_RS18365	COG4677	pectinesterase activity
G7969_RS18380	COG4968	Prepilin-type N-terminal cleavage methylation domain
G7969_RS18390	COG4796	Type ii and iii secretion system protein
G7969_RS18415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G7969_RS18455	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
G7969_RS18465	COG0534	Mate efflux family protein
G7969_RS18470	COG3251	PFAM MbtH domain protein
G7969_RS18480	COG0529	Catalyzes the synthesis of activated sulfate
G7969_RS18515	COG1104	cysteine desulfurase activity
G7969_RS18570	COG2706	6-phosphogluconolactonase activity
G7969_RS18595	COG0730	response to heat
G7969_RS18640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G7969_RS18650	COG0028	Belongs to the TPP enzyme family
G7969_RS18665	COG1607	acyl-coa hydrolase
G7969_RS18715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G7969_RS18735	COG3039	Transposase
G7969_RS18765	COG1846	Transcriptional regulator
G7969_RS18770	COG1024	Enoyl-CoA hydratase
G7969_RS18775	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS18815	COG2814	Major facilitator Superfamily
G7969_RS18825	COG1640	4-alpha-glucanotransferase
G7969_RS18830	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G7969_RS18840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G7969_RS18845	COG0366	Alpha amylase catalytic
G7969_RS18850	COG0366	Alpha amylase catalytic
G7969_RS18855	COG0297	glycogen (starch) synthase activity
G7969_RS18865	COG4771	TonB-dependent receptor
G7969_RS18875	COG3634	alkyl hydroperoxide reductase activity
G7969_RS18880	COG0735	belongs to the Fur family
G7969_RS18900	COG1918	ferrous iron import across plasma membrane
G7969_RS18900	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G7969_RS18910	COG3447	MASE1 domain protein
G7969_RS18910	COG5002	protein histidine kinase activity
G7969_RS18910	COG5001	Diguanylate cyclase
G7969_RS18920	COG0840	transmembrane signaling receptor activity
G7969_RS18940	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G7969_RS18955	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G7969_RS18965	COG0454	-acetyltransferase
G7969_RS18965	COG0456	acetyltransferase
G7969_RS19030	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G7969_RS19050	COG3706	GGDEF domain
G7969_RS19055	COG0531	amino acid
G7969_RS19060	COG0534	Mate efflux family protein
G7969_RS19070	COG2197	response regulator
G7969_RS19080	COG1649	PFAM Uncharacterised BCR, COG1649
G7969_RS19080	COG0726	polysaccharide deacetylase
G7969_RS19085	COG1215	transferase activity, transferring glycosyl groups
G7969_RS19100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS19105	COG2274	protein secretion by the type I secretion system
G7969_RS19140	COG0840	transmembrane signaling receptor activity
G7969_RS19150	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS19160	COG2070	2-Nitropropane dioxygenase
G7969_RS19165	COG0583	DNA-binding transcription factor activity
G7969_RS19170	COG1695	Transcriptional regulator
G7969_RS19185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7969_RS19190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS19195	COG0745	RESPONSE REGULATOR receiver
G7969_RS19200	COG2205	protein histidine kinase activity
G7969_RS19215	COG0589	response to stress
G7969_RS19225	COG0789	Transcriptional regulator
G7969_RS19235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G7969_RS19255	COG1764	response to oxidative stress
G7969_RS19270	COG0473	3-isopropylmalate dehydrogenase activity
G7969_RS19300	COG2916	Histone family protein nucleoid-structuring protein H-NS
G7969_RS19305	COG2188	Transcriptional regulator
G7969_RS19310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS19315	COG2197	response regulator
G7969_RS19335	COG1815	bacterial-type flagellum-dependent cell motility
G7969_RS19345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G7969_RS19350	COG1749	Flagellar hook protein flgE
G7969_RS19355	COG4787	bacterial-type flagellum-dependent cell motility
G7969_RS19365	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G7969_RS19370	COG1706	bacterial-type flagellum-dependent cell motility
G7969_RS19380	COG1256	bacterial-type flagellum assembly
G7969_RS19400	COG2226	methyltransferase
G7969_RS19415	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7969_RS19420	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS19430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G7969_RS19450	COG2986	histidine ammonia-lyase
G7969_RS19460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G7969_RS19470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7969_RS19480	COG0204	Acyl-transferase
G7969_RS19495	COG1987	bacterial-type flagellum assembly
G7969_RS19500	COG1338	Plays a role in the flagellum-specific transport system
G7969_RS19530	COG2197	response regulator
G7969_RS19555	COG1846	Transcriptional regulator
G7969_RS19570	COG1677	Flagellar hook-basal body complex protein FliE
G7969_RS19580	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G7969_RS19615	COG2203	Gaf domain
G7969_RS19615	COG3706	GGDEF domain
G7969_RS19615	COG4251	negative regulation of phosphorylation
G7969_RS19615	COG5001	Diguanylate cyclase
G7969_RS19625	COG2203	Gaf domain
G7969_RS19625	COG3706	GGDEF domain
G7969_RS19625	COG4251	negative regulation of phosphorylation
G7969_RS19625	COG5001	Diguanylate cyclase
G7969_RS19655	COG2814	Major facilitator Superfamily
G7969_RS19665	COG0583	DNA-binding transcription factor activity
G7969_RS19690	COG0251	oxidation-reduction process
G7969_RS19700	COG0640	Transcriptional regulator
G7969_RS19715	COG1522	sequence-specific DNA binding
G7969_RS19725	COG0251	oxidation-reduction process
G7969_RS19785	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7969_RS19810	COG0683	leucine binding
G7969_RS19835	COG3766	membrane
G7969_RS19855	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G7969_RS19890	COG1609	Transcriptional regulator
G7969_RS19900	COG1621	beta-fructofuranosidase activity
G7969_RS19930	COG0114	fumarate hydratase activity
G7969_RS19935	COG0477	Major facilitator Superfamily
G7969_RS19950	COG1742	UPF0060 membrane protein
G7969_RS19955	COG0668	transmembrane transport
G7969_RS19985	COG0730	response to heat
G7969_RS19990	COG0583	DNA-binding transcription factor activity
G7969_RS20000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7969_RS20005	COG0730	response to heat
G7969_RS20010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G7969_RS20035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G7969_RS20055	COG3550	peptidyl-serine autophosphorylation
G7969_RS20090	COG0251	oxidation-reduction process
G7969_RS20100	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G7969_RS20105	COG1294	oxidase, subunit
G7969_RS20110	COG1271	oxidase subunit
G7969_RS20120	COG2951	lytic endotransglycosylase activity
G7969_RS20155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7969_RS20155	COG0473	3-isopropylmalate dehydrogenase activity
G7969_RS20160	COG0436	Aminotransferase
G7969_RS20165	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7969_RS20185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G7969_RS20195	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G7969_RS20200	COG0840	transmembrane signaling receptor activity
G7969_RS20205	COG2223	nitrite transmembrane transporter activity
G7969_RS20210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7969_RS20220	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G7969_RS20225	COG0243	molybdopterin cofactor binding
G7969_RS20240	COG0534	Mate efflux family protein
G7969_RS20250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G7969_RS20260	COG0840	transmembrane signaling receptor activity
G7969_RS20265	COG5001	Diguanylate cyclase
G7969_RS20265	COG3300	MHYT domain
G7969_RS20270	COG1271	oxidase subunit
G7969_RS20275	COG1294	oxidase, subunit
G7969_RS20325	COG0745	RESPONSE REGULATOR receiver
G7969_RS20345	COG2197	response regulator
G7969_RS20350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G7969_RS20355	COG0800	Aldolase
G7969_RS20370	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G7969_RS20395	COG2274	protein secretion by the type I secretion system
G7969_RS20435	COG1858	cytochrome C peroxidase
G7969_RS20440	COG1253	flavin adenine dinucleotide binding
G7969_RS20460	COG1858	cytochrome C peroxidase
G7969_RS20490	COG2205	protein histidine kinase activity
G7969_RS20495	COG0745	RESPONSE REGULATOR receiver
G7969_RS20510	COG3813	Protein conserved in bacteria
G7969_RS20530	COG3300	MHYT domain
G7969_RS20530	COG5001	Diguanylate cyclase
G7969_RS20545	COG1942	4-Oxalocrotonate Tautomerase
G7969_RS20550	COG2267	carboxylic ester hydrolase activity
G7969_RS20565	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G7969_RS20570	COG4149	molybdate abc transporter
G7969_RS20575	COG2066	Belongs to the glutaminase family
G7969_RS20585	COG2197	response regulator
G7969_RS20595	COG3501	Rhs element vgr protein
G7969_RS20605	COG5444	nuclease activity
G7969_RS20635	COG0640	Transcriptional regulator
G7969_RS20640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7969_RS20645	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G7969_RS20655	COG1064	alcohol dehydrogenase
G7969_RS20680	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
G7969_RS20705	COG1064	alcohol dehydrogenase
G7969_RS20715	COG0583	DNA-binding transcription factor activity
G7969_RS20725	COG3321	synthase
G7969_RS20725	COG0604	alcohol dehydrogenase
G7969_RS20725	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS20740	COG2030	dehydratase
G7969_RS20790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS20800	COG0583	DNA-binding transcription factor activity
G7969_RS20815	COG1764	response to oxidative stress
G7969_RS20820	COG1846	Transcriptional regulator
G7969_RS20825	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G7969_RS20830	COG1877	trehalose-phosphatase activity
G7969_RS20845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G7969_RS20870	COG2197	response regulator
G7969_RS20910	COG4964	Belongs to the GSP D family
G7969_RS20965	COG0673	inositol 2-dehydrogenase activity
G7969_RS20970	COG2831	hemolysin activation secretion protein
G7969_RS21000	COG0673	inositol 2-dehydrogenase activity
G7969_RS21010	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS21015	COG4689	acetoacetate decarboxylase
G7969_RS21040	COG1278	Cold shock
G7969_RS21045	COG3158	transport of potassium into the cell
G7969_RS21050	COG3300	MHYT domain
G7969_RS21050	COG5001	Diguanylate cyclase
G7969_RS21055	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G7969_RS21065	COG0243	molybdopterin cofactor binding
G7969_RS21070	COG2223	nitrite transmembrane transporter activity
G7969_RS21095	COG0745	RESPONSE REGULATOR receiver
G7969_RS21130	COG3220	belongs to the UPF0276 family
G7969_RS21170	COG0840	transmembrane signaling receptor activity
G7969_RS21215	COG1596	polysaccharide export
G7969_RS21220	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G7969_RS21225	COG3206	protein involved in exopolysaccharide biosynthesis
G7969_RS21225	COG0489	protein tyrosine kinase activity
G7969_RS21230	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7969_RS21235	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G7969_RS21240	COG2244	polysaccharide biosynthetic process
G7969_RS21255	COG0110	maltose O-acetyltransferase activity
G7969_RS21275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G7969_RS21285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G7969_RS21325	COG0583	DNA-binding transcription factor activity
G7969_RS21335	COG1301	dicarboxylic acid transport
G7969_RS21340	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G7969_RS21360	COG1999	signal sequence binding
G7969_RS21375	COG1454	alcohol dehydrogenase
G7969_RS21380	COG0477	Major facilitator Superfamily
G7969_RS21385	COG0352	thiamine-phosphate diphosphorylase activity
G7969_RS21405	COG2197	response regulator
G7969_RS21410	COG3850	Histidine kinase
G7969_RS21415	COG1763	Mo-molybdopterin cofactor biosynthetic process
G7969_RS21420	COG2181	nitrate reductase activity
G7969_RS21425	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
G7969_RS21430	COG1140	nitrate reductase beta subunit
G7969_RS21435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G7969_RS21440	COG2223	nitrite transmembrane transporter activity
G7969_RS21455	COG0826	peptidase U32
G7969_RS21460	COG0826	peptidase U32
G7969_RS21465	COG3154	lipid carrier protein
G7969_RS21495	COG1396	sequence-specific DNA binding
G7969_RS21505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7969_RS21510	COG3604	Transcriptional regulator
G7969_RS21515	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
G7969_RS21555	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS21575	COG1063	alcohol dehydrogenase
G7969_RS21580	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS21585	COG3265	gluconokinase activity
G7969_RS21590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7969_RS21595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G7969_RS21600	COG0436	Aminotransferase
G7969_RS21610	COG0511	ligase activity, forming carbon-carbon bonds
G7969_RS21620	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G7969_RS21625	COG1984	allophanate hydrolase subunit 2
G7969_RS21635	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G7969_RS21640	COG4221	oxidoreductase activity
G7969_RS21645	COG0765	amino acid transport
G7969_RS21650	COG0765	amino acid transport
G7969_RS21655	COG1126	abc transporter atp-binding protein
G7969_RS21660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7969_RS21680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS21710	COG2801	Transposase and inactivated derivatives
G7969_RS21735	COG1309	transcriptional regulator
G7969_RS21755	COG0583	DNA-binding transcription factor activity
G7969_RS21760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G7969_RS21790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G7969_RS21820	COG1674	ftsk spoiiie
G7969_RS21840	COG5434	Belongs to the glycosyl hydrolase 28 family
G7969_RS21865	COG4886	Leucine-rich repeat (LRR) protein
G7969_RS21870	COG1450	Type ii and iii secretion system protein
G7969_RS21875	COG2207	Transcriptional regulator
G7969_RS21920	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G7969_RS21925	COG4789	Type iii secretion
G7969_RS21940	COG4790	Type iii secretion
G7969_RS21980	COG0745	RESPONSE REGULATOR receiver
G7969_RS21985	COG2197	response regulator
G7969_RS21995	COG1595	DNA-templated transcription, initiation
G7969_RS22045	COG0840	transmembrane signaling receptor activity
G7969_RS22070	COG1051	belongs to the nudix hydrolase family
G7969_RS22070	COG1056	cytidyltransferase-related domain
G7969_RS22075	COG2271	Major facilitator Superfamily
G7969_RS22090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7969_RS22095	COG2721	sulfolactate sulfo-lyase activity
G7969_RS22105	COG2271	Major facilitator Superfamily
G7969_RS22115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G7969_RS22120	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G7969_RS22130	COG0583	DNA-binding transcription factor activity
G7969_RS22140	COG0697	spore germination
G7969_RS22155	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G7969_RS22165	COG1309	transcriptional regulator
G7969_RS22175	COG0579	oxidoreductase
G7969_RS22190	COG4206	TonB-dependent receptor
G7969_RS22195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G7969_RS22210	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G7969_RS22225	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G7969_RS22235	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G7969_RS22240	COG3620	sequence-specific DNA binding
G7969_RS22245	COG0587	DNA-directed DNA polymerase activity
G7969_RS22260	COG2814	Major facilitator Superfamily
G7969_RS22275	COG0436	Aminotransferase
G7969_RS22290	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS22290	COG3321	synthase
G7969_RS22290	COG1028	Short-chain dehydrogenase reductase Sdr
G7969_RS22290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G7969_RS22290	COG0300	oxidoreductase activity
G7969_RS22305	COG2192	nodulation
G7969_RS22310	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS22335	COG0525	valine-tRNA ligase activity
G7969_RS22350	COG3916	Acyl-homoserine-lactone synthase
G7969_RS22355	COG2197	response regulator
G7969_RS22485	COG3501	Rhs element vgr protein
G7969_RS22545	COG3501	Rhs element vgr protein
G7969_RS22575	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G7969_RS22595	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G7969_RS22615	COG1730	sister chromatid segregation
G7969_RS22620	COG1858	cytochrome C peroxidase
G7969_RS22705	COG1690	Belongs to the RtcB family
G7969_RS22710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G7969_RS22735	COG3483	tryptophan 2,3-dioxygenase activity
G7969_RS22750	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G7969_RS22770	COG1960	acyl-CoA dehydrogenase activity
G7969_RS22800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G7969_RS22805	COG0134	indole-3-glycerol-phosphate synthase activity
G7969_RS22810	COG0019	diaminopimelate decarboxylase activity
G7969_RS22815	COG0259	pyridoxamine-phosphate oxidase activity
G7969_RS22820	COG0583	DNA-binding transcription factor activity
G7969_RS22825	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G7969_RS22850	COG1024	Enoyl-CoA hydratase
G7969_RS22875	COG2807	transmembrane transport
G7969_RS22880	COG0519	Catalyzes the synthesis of GMP from XMP
G7969_RS22895	COG2814	Major facilitator Superfamily
G7969_RS22905	COG1335	isochorismatase
G7969_RS22915	COG1846	Transcriptional regulator
G7969_RS22925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS22945	COG2132	Multicopper oxidase
G7969_RS22950	COG0745	RESPONSE REGULATOR receiver
G7969_RS22955	COG5002	protein histidine kinase activity
G7969_RS22970	COG1960	acyl-CoA dehydrogenase activity
G7969_RS22975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G7969_RS22990	COG1024	Enoyl-CoA hydratase
G7969_RS22995	COG1024	Enoyl-CoA hydratase
G7969_RS23000	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G7969_RS23005	COG1522	sequence-specific DNA binding
G7969_RS23030	COG3251	PFAM MbtH domain protein
G7969_RS23035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G7969_RS23050	COG4941	Belongs to the sigma-70 factor family
G7969_RS23055	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G7969_RS23070	COG0438	transferase activity, transferring glycosyl groups
G7969_RS23115	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
G7969_RS23120	COG3411	Ferredoxin
G7969_RS23135	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G7969_RS23135	COG1648	precorrin-2 dehydrogenase activity
G7969_RS23145	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
G7969_RS23180	COG1797	cobyrinic acid a,c-diamide synthase activity
G7969_RS23185	COG0778	Nitroreductase
G7969_RS23240	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G7969_RS23245	COG2151	metal-sulfur cluster biosynthetic enzyme
G7969_RS23250	COG3396	Phenylacetate-CoA oxygenase
G7969_RS23255	COG3460	Phenylacetate-CoA oxygenase
G7969_RS23260	COG3396	Phenylacetate-CoA oxygenase
G7969_RS23265	COG1404	Belongs to the peptidase S8 family
G7969_RS23290	COG0784	Response regulator, receiver
G7969_RS23290	COG0835	chemotaxis
G7969_RS23300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G7969_RS23330	COG0300	oxidoreductase activity
G7969_RS23355	COG5297	Belongs to the glycosyl hydrolase family 6
G7969_RS23360	COG3039	Transposase
G7969_RS23430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G7969_RS23455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS23465	COG3210	domain, Protein
G7969_RS23485	COG3210	domain, Protein
G7969_RS23485	COG3210	domain, Protein
G7969_RS23560	COG3039	Transposase
G7969_RS23585	COG4974	Belongs to the 'phage' integrase family
G7969_RS23590	COG0582	viral genome integration into host DNA
G7969_RS23595	COG4974	Belongs to the 'phage' integrase family
G7969_RS23620	COG3039	Transposase
G7969_RS23695	COG3039	Transposase
G7969_RS23700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G7969_RS23745	COG2910	NAD(P)H-binding
G7969_RS23765	COG0443	Heat shock 70 kDa protein
G7969_RS23770	COG1914	H( )-stimulated, divalent metal cation uptake system
G7969_RS23775	COG3706	GGDEF domain
G7969_RS23780	COG3501	Rhs element vgr protein
G7969_RS23800	COG0668	transmembrane transport
G7969_RS23820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G7969_RS23835	COG0840	transmembrane signaling receptor activity
G7969_RS23845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G7969_RS23885	COG0537	adenosine 5'-monophosphoramidase activity
G7969_RS23920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G7969_RS23940	COG2423	ornithine cyclodeaminase activity
G7969_RS23945	COG1522	sequence-specific DNA binding
G7969_RS23950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7969_RS23960	COG1126	abc transporter atp-binding protein
G7969_RS23965	COG0583	DNA-binding transcription factor activity
G7969_RS23975	COG1902	pentaerythritol trinitrate reductase activity
G7969_RS24025	COG0583	DNA-binding transcription factor activity
G7969_RS24050	COG2814	Major facilitator Superfamily
G7969_RS24075	COG0019	diaminopimelate decarboxylase activity
G7969_RS24085	COG4264	IucA IucC family
G7969_RS24090	COG4264	IucA IucC family
G7969_RS24095	COG2814	Major facilitator Superfamily
G7969_RS24100	COG4264	IucA IucC family
G7969_RS24105	COG2423	ornithine cyclodeaminase activity
G7969_RS24110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G7969_RS24130	COG4774	siderophore transport
G7969_RS24140	COG2223	nitrite transmembrane transporter activity
G7969_RS24180	COG0318	PFAM AMP-dependent synthetase and ligase
G7969_RS24220	COG0840	transmembrane signaling receptor activity
G7969_RS24225	COG0567	Dehydrogenase, E1 component
G7969_RS24230	COG0204	Acyl-transferase
G7969_RS24245	COG4263	nitrous-oxide reductase activity
G7969_RS24295	COG2831	hemolysin activation secretion protein
G7969_RS24330	COG2824	Alkylphosphonate utilization operon protein PhnA
G7969_RS24340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G7969_RS24350	COG0762	integral membrane protein
G7969_RS24375	COG1191	sigma factor activity
G7969_RS24390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G7969_RS24400	COG1309	transcriptional regulator
G7969_RS24405	COG2271	Major facilitator Superfamily
G7969_RS24410	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G7969_RS24415	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G7969_RS24420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS24430	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G7969_RS24435	COG0745	RESPONSE REGULATOR receiver
G7969_RS24440	COG2201	protein-glutamate methylesterase activity
G7969_RS24445	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G7969_RS24455	COG0840	transmembrane signaling receptor activity
G7969_RS24460	COG0835	chemotaxis
G7969_RS24470	COG0745	RESPONSE REGULATOR receiver
G7969_RS24475	COG1360	Flagellar Motor Protein
G7969_RS24510	COG0477	Major facilitator Superfamily
G7969_RS24515	COG2267	carboxylic ester hydrolase activity
G7969_RS24535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G7969_RS24545	COG0644	oxidoreductase
G7969_RS24550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G7969_RS24555	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G7969_RS24585	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G7969_RS24585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS24625	COG1045	serine acetyltransferase
G7969_RS24630	COG2205	protein histidine kinase activity
G7969_RS24655	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G7969_RS24665	COG0469	pyruvate kinase activity
G7969_RS24675	COG0583	DNA-binding transcription factor activity
G7969_RS24690	COG2205	protein histidine kinase activity
G7969_RS24695	COG0745	RESPONSE REGULATOR receiver
G7969_RS24705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS24715	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G7969_RS24740	COG1136	(ABC) transporter
G7969_RS24745	COG0577	efflux transmembrane transporter activity
G7969_RS24745	COG1136	(ABC) transporter
G7969_RS24790	COG0667	Aldo Keto reductase
G7969_RS24875	COG2192	nodulation
G7969_RS24895	COG4651	solute:proton antiporter activity
G7969_RS24895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G7969_RS24920	COG3039	Transposase
G7969_RS24945	COG3256	nitric oxide reductase
G7969_RS24950	COG2188	Transcriptional regulator
G7969_RS24955	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
G7969_RS24960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G7969_RS24995	COG0583	DNA-binding transcription factor activity
G7969_RS25050	COG0705	Rhomboid family
G7969_RS25070	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
G7969_RS25090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G7969_RS25105	COG3210	domain, Protein
G7969_RS25155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G7969_RS25160	COG0642	Histidine kinase
G7969_RS25165	COG0745	RESPONSE REGULATOR receiver
G7969_RS25180	COG0837	glucose binding
G7969_RS25190	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G7969_RS25200	COG0589	response to stress
G7969_RS25215	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G7969_RS25220	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G7969_RS25230	COG1845	cytochrome c oxidase, subunit III
G7969_RS25255	COG2271	Major facilitator Superfamily
G7969_RS25270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G7969_RS25280	COG0765	amino acid transport
G7969_RS25285	COG0010	Belongs to the arginase family
G7969_RS25290	COG2197	response regulator
G7969_RS25315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G7969_RS25320	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS25330	COG0583	DNA-binding transcription factor activity
G7969_RS25335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G7969_RS25340	COG2814	Major facilitator Superfamily
G7969_RS25355	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G7969_RS25360	COG1538	Outer membrane efflux protein
G7969_RS25415	COG1012	belongs to the aldehyde dehydrogenase family
G7969_RS25420	COG0473	3-isopropylmalate dehydrogenase activity
G7969_RS25430	COG2271	Major facilitator Superfamily
G7969_RS25435	COG2721	sulfolactate sulfo-lyase activity
G7969_RS25445	COG1475	DNA binding
G7969_RS25455	COG3969	phosphoadenosine phosphosulfate
G7969_RS25460	COG5295	Hep Hag repeat protein
G7969_RS25470	COG2205	protein histidine kinase activity
G7969_RS25470	COG0784	Response regulator, receiver
G7969_RS25475	COG4251	negative regulation of phosphorylation
G7969_RS25475	COG2203	Gaf domain
G7969_RS25475	COG5001	Diguanylate cyclase
G7969_RS25475	COG3706	GGDEF domain
G7969_RS25485	COG2801	Transposase and inactivated derivatives
G7969_RS25515	COG4213	ABC transporter substrate-binding protein
G7969_RS25520	COG1129	ABC transporter
G7969_RS25525	COG4214	carbohydrate transport
G7969_RS25530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G7969_RS25535	COG1609	Transcriptional regulator
G7969_RS25635	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G7969_RS25645	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G7969_RS25670	COG2204	response regulator
G7969_RS25690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G7969_RS25710	COG2205	protein histidine kinase activity
G7969_RS25720	COG2252	PERMEase