locus-tag	class	description
G8D25_RS00065	COG1024	Enoyl-CoA hydratase
G8D25_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS00130	COG2916	Histone family protein nucleoid-structuring protein H-NS
G8D25_RS00135	COG0745	RESPONSE REGULATOR receiver
G8D25_RS00140	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G8D25_RS00155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS00170	COG5002	protein histidine kinase activity
G8D25_RS00190	COG1881	PFAM PEBP family protein
G8D25_RS00210	COG0038	chloride channel
G8D25_RS00250	COG5002	protein histidine kinase activity
G8D25_RS00250	COG5001	Diguanylate cyclase
G8D25_RS00250	COG3447	MASE1 domain protein
G8D25_RS00260	COG4377	Putative membrane peptidase family (DUF2324)
G8D25_RS00270	COG4191	Histidine kinase
G8D25_RS00275	COG0477	Major facilitator Superfamily
G8D25_RS00300	COG1278	Cold shock
G8D25_RS00310	COG2252	PERMEase
G8D25_RS00320	COG2205	protein histidine kinase activity
G8D25_RS00340	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G8D25_RS00355	COG2204	response regulator
G8D25_RS00360	COG2204	response regulator
G8D25_RS00365	COG5487	UPF0391 membrane protein
G8D25_RS00390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G8D25_RS00440	COG4977	sequence-specific DNA binding
G8D25_RS00480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8D25_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS00505	COG0300	oxidoreductase activity
G8D25_RS00525	COG1609	Transcriptional regulator
G8D25_RS00530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D25_RS00535	COG4214	carbohydrate transport
G8D25_RS00540	COG1129	ABC transporter
G8D25_RS00545	COG4213	ABC transporter substrate-binding protein
G8D25_RS00605	COG0456	acetyltransferase
G8D25_RS00640	COG5295	Hep Hag repeat protein
G8D25_RS00645	COG3969	phosphoadenosine phosphosulfate
G8D25_RS00655	COG1475	DNA binding
G8D25_RS00665	COG2721	sulfolactate sulfo-lyase activity
G8D25_RS00670	COG2271	Major facilitator Superfamily
G8D25_RS00680	COG0473	3-isopropylmalate dehydrogenase activity
G8D25_RS00730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS00735	COG0251	oxidation-reduction process
G8D25_RS00740	COG0154	amidase activity
G8D25_RS00750	COG1396	sequence-specific DNA binding
G8D25_RS00770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS00785	COG2814	Major facilitator Superfamily
G8D25_RS00790	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS00795	COG0583	DNA-binding transcription factor activity
G8D25_RS00810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS00810	COG2022	thiamine diphosphate biosynthetic process
G8D25_RS00840	COG2197	response regulator
G8D25_RS00850	COG0765	amino acid transport
G8D25_RS00860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS00865	COG0583	DNA-binding transcription factor activity
G8D25_RS00875	COG2271	Major facilitator Superfamily
G8D25_RS00910	COG1845	cytochrome c oxidase, subunit III
G8D25_RS00920	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8D25_RS00925	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G8D25_RS00950	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
G8D25_RS00960	COG0837	glucose binding
G8D25_RS00965	COG1737	Transcriptional regulator
G8D25_RS00965	COG0837	glucose binding
G8D25_RS00975	COG0745	RESPONSE REGULATOR receiver
G8D25_RS00980	COG0642	Histidine kinase
G8D25_RS01000	COG0477	Major facilitator Superfamily
G8D25_RS01005	COG0352	thiamine-phosphate diphosphorylase activity
G8D25_RS01090	COG1695	Transcriptional regulator
G8D25_RS01110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8D25_RS01135	COG0745	RESPONSE REGULATOR receiver
G8D25_RS01155	COG0589	response to stress
G8D25_RS01180	COG0789	Transcriptional regulator
G8D25_RS01190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8D25_RS01220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G8D25_RS01255	COG2916	Histone family protein nucleoid-structuring protein H-NS
G8D25_RS01260	COG2188	Transcriptional regulator
G8D25_RS01290	COG1815	bacterial-type flagellum-dependent cell motility
G8D25_RS01300	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G8D25_RS01305	COG1749	Flagellar hook protein flgE
G8D25_RS01310	COG4787	bacterial-type flagellum-dependent cell motility
G8D25_RS01320	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G8D25_RS01325	COG1706	bacterial-type flagellum-dependent cell motility
G8D25_RS01335	COG1256	bacterial-type flagellum assembly
G8D25_RS01365	COG1987	bacterial-type flagellum assembly
G8D25_RS01370	COG1338	Plays a role in the flagellum-specific transport system
G8D25_RS01400	COG2197	response regulator
G8D25_RS01425	COG1846	Transcriptional regulator
G8D25_RS01440	COG1677	Flagellar hook-basal body complex protein FliE
G8D25_RS01450	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G8D25_RS01495	COG3706	GGDEF domain
G8D25_RS01495	COG5001	Diguanylate cyclase
G8D25_RS01495	COG2203	Gaf domain
G8D25_RS01495	COG4251	negative regulation of phosphorylation
G8D25_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS01565	COG2223	nitrite transmembrane transporter activity
G8D25_RS01575	COG4774	siderophore transport
G8D25_RS01590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G8D25_RS01595	COG2423	ornithine cyclodeaminase activity
G8D25_RS01600	COG4264	IucA IucC family
G8D25_RS01605	COG2814	Major facilitator Superfamily
G8D25_RS01610	COG4264	IucA IucC family
G8D25_RS01615	COG4264	IucA IucC family
G8D25_RS01625	COG0019	diaminopimelate decarboxylase activity
G8D25_RS01720	COG3210	domain, Protein
G8D25_RS01720	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G8D25_RS01720	COG3064	Membrane
G8D25_RS01750	COG0753	catalase activity
G8D25_RS01755	COG0644	oxidoreductase
G8D25_RS01790	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
G8D25_RS01815	COG3300	MHYT domain
G8D25_RS01815	COG5001	Diguanylate cyclase
G8D25_RS01865	COG0583	DNA-binding transcription factor activity
G8D25_RS01905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D25_RS01915	COG2188	Transcriptional regulator
G8D25_RS01920	COG0826	peptidase U32
G8D25_RS01925	COG0826	peptidase U32
G8D25_RS01930	COG3154	lipid carrier protein
G8D25_RS01940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8D25_RS01965	COG2223	nitrite transmembrane transporter activity
G8D25_RS01975	COG1140	nitrate reductase beta subunit
G8D25_RS01985	COG2181	nitrate reductase activity
G8D25_RS01990	COG1763	Mo-molybdopterin cofactor biosynthetic process
G8D25_RS01995	COG3850	Histidine kinase
G8D25_RS02000	COG2197	response regulator
G8D25_RS02005	COG0204	Acyl-transferase
G8D25_RS02035	COG4651	solute:proton antiporter activity
G8D25_RS02035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8D25_RS02055	COG2192	nodulation
G8D25_RS02075	COG0151	Belongs to the GarS family
G8D25_RS02085	COG2267	carboxylic ester hydrolase activity
G8D25_RS02095	COG2885	chlorophyll binding
G8D25_RS02110	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G8D25_RS02145	COG0300	oxidoreductase activity
G8D25_RS02170	COG0583	DNA-binding transcription factor activity
G8D25_RS02180	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D25_RS02185	COG0604	alcohol dehydrogenase
G8D25_RS02190	COG0300	oxidoreductase activity
G8D25_RS02195	COG1309	transcriptional regulator
G8D25_RS02235	COG0251	oxidation-reduction process
G8D25_RS02245	COG1522	sequence-specific DNA binding
G8D25_RS02250	COG2175	clavaminate synthase activity
G8D25_RS02275	COG3209	COG3209 Rhs family protein
G8D25_RS02330	COG1301	dicarboxylic acid transport
G8D25_RS02340	COG0583	DNA-binding transcription factor activity
G8D25_RS02345	COG4221	oxidoreductase activity
G8D25_RS02355	COG1073	alpha beta
G8D25_RS02375	COG0656	L-ascorbic acid biosynthetic process
G8D25_RS02380	COG0583	DNA-binding transcription factor activity
G8D25_RS02415	COG1858	cytochrome C peroxidase
G8D25_RS02435	COG3460	Phenylacetate-CoA oxygenase
G8D25_RS02440	COG3396	Phenylacetate-CoA oxygenase
G8D25_RS02445	COG2151	metal-sulfur cluster biosynthetic enzyme
G8D25_RS02450	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G8D25_RS02500	COG1902	pentaerythritol trinitrate reductase activity
G8D25_RS02505	COG2910	NAD(P)H-binding
G8D25_RS02515	COG1733	regulation of RNA biosynthetic process
G8D25_RS02545	COG0778	Nitroreductase
G8D25_RS02550	COG1797	cobyrinic acid a,c-diamide synthase activity
G8D25_RS02585	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
G8D25_RS02595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8D25_RS02595	COG1648	precorrin-2 dehydrogenase activity
G8D25_RS02610	COG3411	Ferredoxin
G8D25_RS02615	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
G8D25_RS02620	COG1126	abc transporter atp-binding protein
G8D25_RS02625	COG0765	amino acid transport
G8D25_RS02630	COG4597	amino acid ABC transporter
G8D25_RS02635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS02645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
G8D25_RS02665	COG1522	sequence-specific DNA binding
G8D25_RS02670	COG2515	1-aminocyclopropane-1-carboxylate deaminase
G8D25_RS02675	COG1024	Enoyl-CoA hydratase
G8D25_RS02680	COG1024	Enoyl-CoA hydratase
G8D25_RS02695	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D25_RS02700	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS02725	COG2814	Major facilitator Superfamily
G8D25_RS02740	COG0519	Catalyzes the synthesis of GMP from XMP
G8D25_RS02745	COG2807	transmembrane transport
G8D25_RS02785	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G8D25_RS02790	COG0583	DNA-binding transcription factor activity
G8D25_RS02795	COG0259	pyridoxamine-phosphate oxidase activity
G8D25_RS02805	COG0134	indole-3-glycerol-phosphate synthase activity
G8D25_RS02810	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8D25_RS02845	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS02865	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
G8D25_RS02875	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G8D25_RS02880	COG1690	Belongs to the RtcB family
G8D25_RS02965	COG1858	cytochrome C peroxidase
G8D25_RS02970	COG1730	sister chromatid segregation
G8D25_RS02990	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G8D25_RS03120	COG2885	chlorophyll binding
G8D25_RS03180	COG0436	Aminotransferase
G8D25_RS03205	COG0587	DNA-directed DNA polymerase activity
G8D25_RS03210	COG3620	sequence-specific DNA binding
G8D25_RS03215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G8D25_RS03240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G8D25_RS03255	COG3842	ATPase activity
G8D25_RS03270	COG1840	ABC-type Fe3 transport system, periplasmic component
G8D25_RS03285	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G8D25_RS03290	COG4206	TonB-dependent receptor
G8D25_RS03305	COG0579	oxidoreductase
G8D25_RS03325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8D25_RS03335	COG0697	spore germination
G8D25_RS03355	COG0583	DNA-binding transcription factor activity
G8D25_RS03365	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G8D25_RS03370	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8D25_RS03380	COG2271	Major facilitator Superfamily
G8D25_RS03390	COG2721	sulfolactate sulfo-lyase activity
G8D25_RS03395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D25_RS03410	COG2271	Major facilitator Superfamily
G8D25_RS03415	COG1051	belongs to the nudix hydrolase family
G8D25_RS03415	COG1056	cytidyltransferase-related domain
G8D25_RS03445	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
G8D25_RS03490	COG1595	DNA-templated transcription, initiation
G8D25_RS03500	COG2197	response regulator
G8D25_RS03505	COG0745	RESPONSE REGULATOR receiver
G8D25_RS03545	COG4790	Type iii secretion
G8D25_RS03565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8D25_RS03615	COG2207	Transcriptional regulator
G8D25_RS03620	COG1450	Type ii and iii secretion system protein
G8D25_RS03625	COG4886	Leucine-rich repeat (LRR) protein
G8D25_RS03715	COG2124	cytochrome p450
G8D25_RS03720	COG3321	synthase
G8D25_RS03720	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS03720	COG4221	oxidoreductase activity
G8D25_RS03720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G8D25_RS03725	COG4221	oxidoreductase activity
G8D25_RS03725	COG3321	synthase
G8D25_RS03725	COG0300	oxidoreductase activity
G8D25_RS03725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8D25_RS03730	COG3321	synthase
G8D25_RS03730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8D25_RS03730	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G8D25_RS03730	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8D25_RS03735	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G8D25_RS03735	COG2070	2-Nitropropane dioxygenase
G8D25_RS03760	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G8D25_RS03805	COG0582	viral genome integration into host DNA
G8D25_RS03820	COG0038	chloride channel
G8D25_RS03825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8D25_RS03865	COG1021	2,3-dihydroxybenzoate-AMP ligase
G8D25_RS03900	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G8D25_RS03900	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
G8D25_RS03905	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G8D25_RS03945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G8D25_RS03955	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G8D25_RS03975	COG0110	maltose O-acetyltransferase activity
G8D25_RS04075	COG1132	(ABC) transporter
G8D25_RS04085	COG4771	TonB-dependent receptor
G8D25_RS04125	COG1021	2,3-dihydroxybenzoate-AMP ligase
G8D25_RS04135	COG0840	transmembrane signaling receptor activity
G8D25_RS04160	COG1012	belongs to the aldehyde dehydrogenase family
G8D25_RS04165	COG0473	3-isopropylmalate dehydrogenase activity
G8D25_RS04170	COG4172	Belongs to the ABC transporter superfamily
G8D25_RS04180	COG0601	transmembrane transport
G8D25_RS04185	COG0747	negative chemotaxis
G8D25_RS04190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS04200	COG1012	belongs to the aldehyde dehydrogenase family
G8D25_RS04210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8D25_RS04220	COG1522	sequence-specific DNA binding
G8D25_RS04235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS04235	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G8D25_RS04245	COG1473	amidohydrolase
G8D25_RS04255	COG1305	Transglutaminase-like
G8D25_RS04285	COG0583	DNA-binding transcription factor activity
G8D25_RS04300	COG3220	belongs to the UPF0276 family
G8D25_RS04310	COG2259	Doxx family
G8D25_RS04345	COG2223	nitrite transmembrane transporter activity
G8D25_RS04360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G8D25_RS04365	COG5001	Diguanylate cyclase
G8D25_RS04365	COG3300	MHYT domain
G8D25_RS04370	COG3158	transport of potassium into the cell
G8D25_RS04375	COG1278	Cold shock
G8D25_RS04400	COG4689	acetoacetate decarboxylase
G8D25_RS04405	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS04420	COG0673	inositol 2-dehydrogenase activity
G8D25_RS04430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8D25_RS04450	COG1621	beta-fructofuranosidase activity
G8D25_RS04460	COG1609	Transcriptional regulator
G8D25_RS04545	COG2831	hemolysin activation secretion protein
G8D25_RS04555	COG2124	cytochrome p450
G8D25_RS04565	COG0673	inositol 2-dehydrogenase activity
G8D25_RS04620	COG4964	Belongs to the GSP D family
G8D25_RS04660	COG2197	response regulator
G8D25_RS04690	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G8D25_RS04705	COG1877	trehalose-phosphatase activity
G8D25_RS04715	COG1846	Transcriptional regulator
G8D25_RS04720	COG1764	response to oxidative stress
G8D25_RS04735	COG2951	lytic endotransglycosylase activity
G8D25_RS04740	COG0583	DNA-binding transcription factor activity
G8D25_RS04750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS04765	COG1279	arginine transmembrane transporter activity
G8D25_RS04770	COG0583	DNA-binding transcription factor activity
G8D25_RS04775	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G8D25_RS04780	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G8D25_RS04790	COG0640	Transcriptional regulator
G8D25_RS04805	COG2197	response regulator
G8D25_RS04815	COG2066	Belongs to the glutaminase family
G8D25_RS04820	COG4149	molybdate abc transporter
G8D25_RS04825	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8D25_RS04840	COG3300	MHYT domain
G8D25_RS04840	COG5001	Diguanylate cyclase
G8D25_RS04865	COG3813	Protein conserved in bacteria
G8D25_RS04880	COG0745	RESPONSE REGULATOR receiver
G8D25_RS04885	COG2205	protein histidine kinase activity
G8D25_RS04910	COG1253	flavin adenine dinucleotide binding
G8D25_RS04915	COG1858	cytochrome C peroxidase
G8D25_RS04945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS04945	COG2205	protein histidine kinase activity
G8D25_RS04965	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
G8D25_RS04970	COG0251	oxidation-reduction process
G8D25_RS04980	COG0800	Aldolase
G8D25_RS04985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8D25_RS04990	COG2197	response regulator
G8D25_RS05010	COG0745	RESPONSE REGULATOR receiver
G8D25_RS05025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G8D25_RS05055	COG1294	oxidase, subunit
G8D25_RS05060	COG1271	oxidase subunit
G8D25_RS05065	COG3300	MHYT domain
G8D25_RS05065	COG5001	Diguanylate cyclase
G8D25_RS05070	COG0840	transmembrane signaling receptor activity
G8D25_RS05085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8D25_RS05095	COG0438	transferase activity, transferring glycosyl groups
G8D25_RS05100	COG0534	Mate efflux family protein
G8D25_RS05140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D25_RS05150	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D25_RS05155	COG2223	nitrite transmembrane transporter activity
G8D25_RS05160	COG0840	transmembrane signaling receptor activity
G8D25_RS05175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D25_RS05190	COG2267	carboxylic ester hydrolase activity
G8D25_RS05215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8D25_RS05220	COG0436	Aminotransferase
G8D25_RS05225	COG0473	3-isopropylmalate dehydrogenase activity
G8D25_RS05225	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8D25_RS05245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G8D25_RS05260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8D25_RS05265	COG1454	alcohol dehydrogenase
G8D25_RS05270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G8D25_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS05310	COG1271	oxidase subunit
G8D25_RS05315	COG1294	oxidase, subunit
G8D25_RS05330	COG0251	oxidation-reduction process
G8D25_RS05365	COG3550	peptidyl-serine autophosphorylation
G8D25_RS05385	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
G8D25_RS05410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G8D25_RS05415	COG0730	response to heat
G8D25_RS05420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D25_RS05430	COG0583	DNA-binding transcription factor activity
G8D25_RS05435	COG0730	response to heat
G8D25_RS05450	COG0668	transmembrane transport
G8D25_RS05455	COG1742	UPF0060 membrane protein
G8D25_RS05475	COG0477	Major facilitator Superfamily
G8D25_RS05480	COG0114	fumarate hydratase activity
G8D25_RS05485	COG4968	Prepilin-type N-terminal cleavage methylation domain
G8D25_RS05520	COG0840	transmembrane signaling receptor activity
G8D25_RS05525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G8D25_RS05545	COG3766	membrane
G8D25_RS05550	COG0683	leucine binding
G8D25_RS05575	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G8D25_RS05615	COG2824	Alkylphosphonate utilization operon protein PhnA
G8D25_RS05620	COG5298	Protein conserved in bacteria
G8D25_RS05645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D25_RS05655	COG0762	integral membrane protein
G8D25_RS05680	COG1191	sigma factor activity
G8D25_RS05695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G8D25_RS05705	COG1309	transcriptional regulator
G8D25_RS05715	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G8D25_RS05720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8D25_RS05725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS05740	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G8D25_RS05745	COG0745	RESPONSE REGULATOR receiver
G8D25_RS05750	COG2201	protein-glutamate methylesterase activity
G8D25_RS05755	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G8D25_RS05765	COG0840	transmembrane signaling receptor activity
G8D25_RS05770	COG0835	chemotaxis
G8D25_RS05780	COG0745	RESPONSE REGULATOR receiver
G8D25_RS05820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D25_RS05825	COG2205	protein histidine kinase activity
G8D25_RS05875	COG2205	protein histidine kinase activity
G8D25_RS05880	COG0745	RESPONSE REGULATOR receiver
G8D25_RS05905	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G8D25_RS05930	COG3023	N-Acetylmuramoyl-L-alanine amidase
G8D25_RS05960	COG0577	efflux transmembrane transporter activity
G8D25_RS05960	COG1136	(ABC) transporter
G8D25_RS06025	COG5002	protein histidine kinase activity
G8D25_RS06030	COG0745	RESPONSE REGULATOR receiver
G8D25_RS06060	COG4221	oxidoreductase activity
G8D25_RS06100	COG0251	oxidation-reduction process
G8D25_RS06105	COG1113	amino acid transport
G8D25_RS06120	COG5297	Belongs to the glycosyl hydrolase family 6
G8D25_RS06165	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8D25_RS06200	COG3278	Belongs to the heme-copper respiratory oxidase family
G8D25_RS06210	COG0596	Alpha beta hydrolase
G8D25_RS06215	COG1942	4-Oxalocrotonate Tautomerase
G8D25_RS06285	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8D25_RS06295	COG0347	Belongs to the P(II) protein family
G8D25_RS06325	COG2910	NAD(P)H-binding
G8D25_RS06345	COG0443	Heat shock 70 kDa protein
G8D25_RS06350	COG1914	H( )-stimulated, divalent metal cation uptake system
G8D25_RS06355	COG3706	GGDEF domain
G8D25_RS06380	COG0668	transmembrane transport
G8D25_RS06400	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G8D25_RS06410	COG1215	transferase activity, transferring glycosyl groups
G8D25_RS06430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8D25_RS06440	COG0537	adenosine 5'-monophosphoramidase activity
G8D25_RS06495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8D25_RS06500	COG0402	S-adenosylhomocysteine deaminase activity
G8D25_RS06530	COG2423	ornithine cyclodeaminase activity
G8D25_RS06535	COG1522	sequence-specific DNA binding
G8D25_RS06540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS06550	COG1126	abc transporter atp-binding protein
G8D25_RS06620	COG2274	protein secretion by the type I secretion system
G8D25_RS06625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS06645	COG2197	response regulator
G8D25_RS06700	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G8D25_RS06720	COG3321	synthase
G8D25_RS06720	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS06720	COG0604	alcohol dehydrogenase
G8D25_RS06745	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS06755	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8D25_RS06775	COG0688	phosphatidylethanolamine metabolic process
G8D25_RS06830	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G8D25_RS06845	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G8D25_RS06865	COG0840	transmembrane signaling receptor activity
G8D25_RS06875	COG5001	Diguanylate cyclase
G8D25_RS06875	COG3447	MASE1 domain protein
G8D25_RS06875	COG5002	protein histidine kinase activity
G8D25_RS06885	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G8D25_RS06885	COG1918	ferrous iron import across plasma membrane
G8D25_RS06905	COG0735	belongs to the Fur family
G8D25_RS06910	COG3634	alkyl hydroperoxide reductase activity
G8D25_RS06920	COG4771	TonB-dependent receptor
G8D25_RS06925	COG3720	iron ion transport
G8D25_RS06935	COG0297	glycogen (starch) synthase activity
G8D25_RS06940	COG0366	Alpha amylase catalytic
G8D25_RS06945	COG0366	Alpha amylase catalytic
G8D25_RS06960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G8D25_RS06965	COG1640	4-alpha-glucanotransferase
G8D25_RS06975	COG2814	Major facilitator Superfamily
G8D25_RS07045	COG1012	belongs to the aldehyde dehydrogenase family
G8D25_RS07050	COG1024	Enoyl-CoA hydratase
G8D25_RS07055	COG1846	Transcriptional regulator
G8D25_RS07075	COG3852	Histidine kinase
G8D25_RS07085	COG0765	amino acid transport
G8D25_RS07090	COG0765	amino acid transport
G8D25_RS07105	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8D25_RS07125	COG1607	acyl-coa hydrolase
G8D25_RS07130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G8D25_RS07160	COG0730	response to heat
G8D25_RS07175	COG0667	Aldo Keto reductase
G8D25_RS07180	COG2814	Major facilitator Superfamily
G8D25_RS07185	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8D25_RS07250	COG0529	Catalyzes the synthesis of activated sulfate
G8D25_RS07265	COG3251	PFAM MbtH domain protein
G8D25_RS07270	COG0534	Mate efflux family protein
G8D25_RS07335	COG4974	Belongs to the 'phage' integrase family
G8D25_RS07340	COG0358	DNA primase activity
G8D25_RS07385	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G8D25_RS07410	COG4796	Type ii and iii secretion system protein
G8D25_RS07420	COG4968	Prepilin-type N-terminal cleavage methylation domain
G8D25_RS07535	COG2944	sequence-specific DNA binding
G8D25_RS07540	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
G8D25_RS07585	COG0659	secondary active sulfate transmembrane transporter activity
G8D25_RS07590	COG0288	reversible hydration of carbon dioxide
G8D25_RS07605	COG0714	Associated with various cellular activities
G8D25_RS07620	COG0725	ABC transporter, periplasmic molybdate-binding protein
G8D25_RS07665	COG0583	DNA-binding transcription factor activity
G8D25_RS07715	COG3657	addiction module killer protein
G8D25_RS07720	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G8D25_RS07725	COG0477	Major facilitator Superfamily
G8D25_RS07735	COG2916	Histone family protein nucleoid-structuring protein H-NS
G8D25_RS07950	COG0640	Transcriptional regulator
G8D25_RS07965	COG1902	pentaerythritol trinitrate reductase activity
G8D25_RS07985	COG4305	rare lipoprotein A
G8D25_RS07995	COG1733	regulation of RNA biosynthetic process
G8D25_RS08010	COG1280	lysine exporter protein (LysE YggA)
G8D25_RS08025	COG0425	Belongs to the sulfur carrier protein TusA family
G8D25_RS08040	COG1942	4-Oxalocrotonate Tautomerase
G8D25_RS08045	COG0235	Class ii aldolase
G8D25_RS08050	COG0477	Major facilitator Superfamily
G8D25_RS08065	COG0330	HflC and HflK could
G8D25_RS08090	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8D25_RS08095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D25_RS08120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8D25_RS08150	COG4681	YaeQ
G8D25_RS08165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
G8D25_RS08175	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS08180	COG3118	belongs to the thioredoxin family
G8D25_RS08190	COG2703	oxygen carrier activity
G8D25_RS08195	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G8D25_RS08200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G8D25_RS08205	COG2982	Protein involved in outer membrane biogenesis
G8D25_RS08220	COG0259	pyridoxamine-phosphate oxidase activity
G8D25_RS08225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G8D25_RS08235	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8D25_RS08240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8D25_RS08250	COG1522	sequence-specific DNA binding
G8D25_RS08255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
G8D25_RS08265	COG3483	tryptophan 2,3-dioxygenase activity
G8D25_RS08275	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS08280	COG2252	PERMEase
G8D25_RS08285	COG0450	alkyl hydroperoxide reductase
G8D25_RS08290	COG4575	ribosome binding
G8D25_RS08310	COG1136	(ABC) transporter
G8D25_RS08315	COG0390	transport system, permease component
G8D25_RS08320	COG0494	nUDIX hydrolase
G8D25_RS08325	COG2175	clavaminate synthase activity
G8D25_RS08345	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8D25_RS08355	COG2391	methyltransferase activity
G8D25_RS08365	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
G8D25_RS08375	COG0823	Involved in the tonB-independent uptake of proteins
G8D25_RS08395	COG0824	Thioesterase
G8D25_RS08400	COG4221	oxidoreductase activity
G8D25_RS08405	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G8D25_RS08410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G8D25_RS08475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8D25_RS08475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G8D25_RS08490	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G8D25_RS08495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8D25_RS08510	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G8D25_RS08545	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G8D25_RS08550	COG1902	pentaerythritol trinitrate reductase activity
G8D25_RS08555	COG1968	undecaprenyl-diphosphatase activity
G8D25_RS08575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G8D25_RS08580	COG0425	Belongs to the sulfur carrier protein TusA family
G8D25_RS08580	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G8D25_RS08600	COG0859	PFAM glycosyl transferase family 9
G8D25_RS08605	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8D25_RS08660	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G8D25_RS08675	COG0540	Belongs to the ATCase OTCase family
G8D25_RS08680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G8D25_RS08685	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G8D25_RS08690	COG1678	Uncharacterized ACR, COG1678
G8D25_RS08695	COG1187	pseudouridine synthase activity
G8D25_RS08700	COG0415	Belongs to the DNA photolyase family
G8D25_RS08705	COG2198	Histidine kinase
G8D25_RS08705	COG0643	Histidine kinase
G8D25_RS08705	COG0784	Response regulator, receiver
G8D25_RS08705	COG2198	Histidine kinase
G8D25_RS08705	COG0784	Response regulator, receiver
G8D25_RS08705	COG0643	Histidine kinase
G8D25_RS08710	COG0840	transmembrane signaling receptor activity
G8D25_RS08715	COG0835	chemotaxis
G8D25_RS08730	COG1773	rubredoxin
G8D25_RS08735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G8D25_RS08745	COG1704	LemA family
G8D25_RS08780	COG4964	Belongs to the GSP D family
G8D25_RS08825	COG0463	Glycosyl transferase, family 2
G8D25_RS08860	COG4269	membrane
G8D25_RS08865	COG0459	protein refolding
G8D25_RS08870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G8D25_RS08875	COG2801	Transposase and inactivated derivatives
G8D25_RS08880	COG0443	Heat shock 70 kDa protein
G8D25_RS08890	COG2974	May be involved in recombination
G8D25_RS08985	COG1309	transcriptional regulator
G8D25_RS09005	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
G8D25_RS09010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G8D25_RS09025	COG2995	paraquat-inducible protein a
G8D25_RS09030	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8D25_RS09030	COG3008	intermembrane lipid transfer
G8D25_RS09040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8D25_RS09110	COG1228	amidohydrolase
G8D25_RS09115	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
G8D25_RS09130	COG0738	Major facilitator superfamily
G8D25_RS09135	COG2027	D-alanyl-D-alanine carboxypeptidase
G8D25_RS09140	COG1763	Mo-molybdopterin cofactor biosynthetic process
G8D25_RS09150	COG0009	L-threonylcarbamoyladenylate synthase
G8D25_RS09155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G8D25_RS09160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G8D25_RS09165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G8D25_RS09175	COG0469	pyruvate kinase activity
G8D25_RS09180	COG0126	phosphoglycerate kinase activity
G8D25_RS09210	COG0859	PFAM glycosyl transferase family 9
G8D25_RS09220	COG0429	hydrolase of the alpha beta-hydrolase fold
G8D25_RS09230	COG4783	chaperone-mediated protein folding
G8D25_RS09235	COG0315	cyclic pyranopterin monophosphate synthase activity
G8D25_RS09335	COG4969	Belongs to the N-Me-Phe pilin family
G8D25_RS09340	COG4969	Belongs to the N-Me-Phe pilin family
G8D25_RS09345	COG0861	Integral membrane protein TerC family
G8D25_RS09350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
G8D25_RS09355	COG0045	succinate-CoA ligase (ADP-forming) activity
G8D25_RS09365	COG2137	regulation of response to DNA damage stimulus
G8D25_RS09370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G8D25_RS09380	COG0642	Histidine kinase
G8D25_RS09390	COG0477	Major facilitator Superfamily
G8D25_RS09465	COG0745	RESPONSE REGULATOR receiver
G8D25_RS09485	COG0513	Belongs to the DEAD box helicase family
G8D25_RS09510	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS09525	COG0493	'glutamate synthase
G8D25_RS09525	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8D25_RS09535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8D25_RS09540	COG1702	phosphate starvation-inducible protein PhoH
G8D25_RS09545	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G8D25_RS09555	COG4535	Mg2 and Co2 transporter CorC
G8D25_RS09560	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G8D25_RS09565	COG0752	glycyl-tRNA synthetase alpha subunit
G8D25_RS09575	COG0751	glycine-tRNA ligase activity
G8D25_RS09580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G8D25_RS09585	COG0204	Acyl-transferase
G8D25_RS09595	COG0346	lactoylglutathione lyase activity
G8D25_RS09600	COG0697	spore germination
G8D25_RS09605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G8D25_RS09610	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G8D25_RS09615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8D25_RS09620	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G8D25_RS09640	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G8D25_RS09655	COG0006	proline dipeptidase activity
G8D25_RS09660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8D25_RS09665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS09675	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
G8D25_RS09680	COG0138	bifunctional purine biosynthesis protein purh
G8D25_RS09685	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G8D25_RS09695	COG0632	four-way junction helicase activity
G8D25_RS09700	COG2255	four-way junction helicase activity
G8D25_RS09715	COG1881	PFAM PEBP family protein
G8D25_RS09720	COG1490	D-aminoacyl-tRNA deacylase activity
G8D25_RS09725	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G8D25_RS09730	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
G8D25_RS09735	COG0316	Belongs to the HesB IscA family
G8D25_RS09750	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G8D25_RS09755	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G8D25_RS09775	COG0418	dihydroorotase activity
G8D25_RS09785	COG0473	3-isopropylmalate dehydrogenase activity
G8D25_RS09790	COG0121	glutamine amidotransferase
G8D25_RS09795	COG1126	abc transporter atp-binding protein
G8D25_RS09800	COG0765	amino acid transport
G8D25_RS09805	COG0765	amino acid transport
G8D25_RS09820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G8D25_RS09830	COG5265	(ABC) transporter
G8D25_RS09840	COG1024	Enoyl-CoA hydratase
G8D25_RS09845	COG0183	Belongs to the thiolase family
G8D25_RS09850	COG1024	Enoyl-CoA hydratase
G8D25_RS09850	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D25_RS09855	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS09870	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
G8D25_RS09875	COG3568	Endonuclease Exonuclease Phosphatase
G8D25_RS09880	COG0494	nUDIX hydrolase
G8D25_RS09890	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G8D25_RS09915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G8D25_RS09930	COG2226	methyltransferase
G8D25_RS09940	COG4178	(ABC) transporter
G8D25_RS09955	COG1238	metal cluster binding
G8D25_RS09975	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G8D25_RS09980	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G8D25_RS09980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G8D25_RS10010	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS10015	COG3265	gluconokinase activity
G8D25_RS10030	COG2391	methyltransferase activity
G8D25_RS10045	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS10060	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G8D25_RS10085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8D25_RS10125	COG0629	single-stranded DNA binding
G8D25_RS10130	COG2814	Major facilitator Superfamily
G8D25_RS10155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G8D25_RS10160	COG0693	protein deglycase activity
G8D25_RS10180	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G8D25_RS10195	COG1137	ATPase activity
G8D25_RS10200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G8D25_RS10205	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G8D25_RS10215	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
G8D25_RS10225	COG1660	Displays ATPase and GTPase activities
G8D25_RS10245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G8D25_RS10255	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
G8D25_RS10260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G8D25_RS10270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G8D25_RS10275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G8D25_RS10280	COG0193	aminoacyl-tRNA hydrolase activity
G8D25_RS10290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
G8D25_RS10295	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G8D25_RS10300	COG0742	ribosomal rna small subunit methyltransferase
G8D25_RS10305	COG0612	Peptidase, M16
G8D25_RS10310	COG0612	Peptidase, M16
G8D25_RS10320	COG0625	glutathione transferase activity
G8D25_RS10330	COG3707	response regulator
G8D25_RS10335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D25_RS10340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D25_RS10345	COG1116	anion transmembrane transporter activity
G8D25_RS10350	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8D25_RS10355	COG1741	Belongs to the pirin family
G8D25_RS10370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G8D25_RS10375	COG1999	signal sequence binding
G8D25_RS10380	COG0109	protoheme IX farnesyltransferase activity
G8D25_RS10385	COG1612	heme a metabolic process
G8D25_RS10415	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
G8D25_RS10425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G8D25_RS10440	COG2226	methyltransferase
G8D25_RS10445	COG1040	competence protein
G8D25_RS10455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G8D25_RS10460	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
G8D25_RS10465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
G8D25_RS10475	COG0588	phosphoglycerate mutase activity
G8D25_RS10500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8D25_RS10505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8D25_RS10515	COG0189	ligase activity
G8D25_RS10525	COG0004	ammonium transporteR
G8D25_RS10570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G8D25_RS10580	COG2204	response regulator
G8D25_RS10590	COG1301	dicarboxylic acid transport
G8D25_RS10595	COG3411	Ferredoxin
G8D25_RS10600	COG2945	thiolester hydrolase activity
G8D25_RS10605	COG1686	Belongs to the peptidase S11 family
G8D25_RS10610	COG2921	Belongs to the UPF0250 family
G8D25_RS10615	COG0583	DNA-binding transcription factor activity
G8D25_RS10625	COG0321	lipoyl(octanoyl) transferase activity
G8D25_RS10630	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G8D25_RS10670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G8D25_RS10675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G8D25_RS10675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G8D25_RS10680	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G8D25_RS10690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G8D25_RS10750	COG2267	carboxylic ester hydrolase activity
G8D25_RS10780	COG2197	response regulator
G8D25_RS10810	COG0018	arginyl-trna synthetase
G8D25_RS10820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G8D25_RS10825	COG4221	oxidoreductase activity
G8D25_RS10835	COG2329	Antibiotic biosynthesis monooxygenase
G8D25_RS10845	COG0789	Transcriptional regulator
G8D25_RS10850	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS10855	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
G8D25_RS10860	COG0288	reversible hydration of carbon dioxide
G8D25_RS10865	COG0183	Belongs to the thiolase family
G8D25_RS10870	COG0300	oxidoreductase activity
G8D25_RS10875	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS10890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G8D25_RS10895	COG3012	SEC-C Motif Domain Protein
G8D25_RS10900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G8D25_RS10910	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
G8D25_RS10915	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G8D25_RS10920	COG4770	biotin carboxylase activity
G8D25_RS10940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8D25_RS10970	COG0596	Alpha beta hydrolase
G8D25_RS11010	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D25_RS11015	COG1703	isobutyryl-CoA mutase activity
G8D25_RS11015	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G8D25_RS11015	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
G8D25_RS11055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8D25_RS11065	COG0430	RNA-3'-phosphate cyclase activity
G8D25_RS11070	COG3541	Predicted nucleotidyltransferase
G8D25_RS11075	COG1690	Belongs to the RtcB family
G8D25_RS11085	COG4650	regulator
G8D25_RS11100	COG1254	Belongs to the acylphosphatase family
G8D25_RS11125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G8D25_RS11130	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G8D25_RS11140	COG0037	tRNA processing
G8D25_RS11145	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8D25_RS11150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G8D25_RS11150	COG0546	phosphoglycolate phosphatase activity
G8D25_RS11170	COG0493	'glutamate synthase
G8D25_RS11185	COG0842	Transport permease protein
G8D25_RS11190	COG1131	(ABC) transporter
G8D25_RS11195	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS11210	COG0583	DNA-binding transcription factor activity
G8D25_RS11215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8D25_RS11230	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS11240	COG2223	nitrite transmembrane transporter activity
G8D25_RS11245	COG0501	Belongs to the peptidase M48B family
G8D25_RS11250	COG0697	spore germination
G8D25_RS11275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G8D25_RS11295	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G8D25_RS11300	COG4682	membrane
G8D25_RS11305	COG0708	Exodeoxyribonuclease III
G8D25_RS11310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G8D25_RS11315	COG2326	polyphosphate kinase activity
G8D25_RS11320	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G8D25_RS11335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G8D25_RS11355	COG0517	IMP dehydrogenase activity
G8D25_RS11365	COG1522	sequence-specific DNA binding
G8D25_RS11405	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS11445	COG2070	2-Nitropropane dioxygenase
G8D25_RS11450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G8D25_RS11465	COG2022	thiamine diphosphate biosynthetic process
G8D25_RS11475	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G8D25_RS11485	COG0351	phosphomethylpyrimidine kinase
G8D25_RS11500	COG1785	Belongs to the alkaline phosphatase family
G8D25_RS11505	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G8D25_RS11510	COG1950	PFAM Membrane protein of
G8D25_RS11515	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
G8D25_RS11525	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G8D25_RS11540	COG0625	glutathione transferase activity
G8D25_RS11545	COG0617	tRNA 3'-terminal CCA addition
G8D25_RS11555	COG3246	L-lysine catabolic process to acetate
G8D25_RS11560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G8D25_RS11590	COG2204	response regulator
G8D25_RS11595	COG5000	phosphorelay sensor kinase activity
G8D25_RS11605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8D25_RS11610	COG0501	Belongs to the peptidase M48B family
G8D25_RS11620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G8D25_RS11630	COG0242	peptide deformylase activity
G8D25_RS11635	COG1652	LysM domain
G8D25_RS11640	COG0758	DNA mediated transformation
G8D25_RS11655	COG0583	DNA-binding transcription factor activity
G8D25_RS11660	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS11665	COG0772	Belongs to the SEDS family
G8D25_RS11670	COG0768	penicillin binding
G8D25_RS11680	COG1792	Involved in formation and maintenance of cell shape
G8D25_RS11685	COG1077	Cell shape determining protein MreB Mrl
G8D25_RS11690	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8D25_RS11695	COG0154	amidase activity
G8D25_RS11710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G8D25_RS11720	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G8D25_RS11725	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G8D25_RS11745	COG0523	cobalamin synthesis protein
G8D25_RS11765	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G8D25_RS11770	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G8D25_RS11780	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
G8D25_RS11810	COG1595	DNA-templated transcription, initiation
G8D25_RS11815	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G8D25_RS11850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G8D25_RS11860	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D25_RS11880	COG2879	small protein
G8D25_RS11885	COG1966	Carbon starvation protein
G8D25_RS11900	COG3622	Belongs to the hyi family
G8D25_RS11910	COG0745	RESPONSE REGULATOR receiver
G8D25_RS11915	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G8D25_RS11920	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G8D25_RS11925	COG3384	dioxygenase
G8D25_RS11930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8D25_RS11940	COG1309	transcriptional regulator
G8D25_RS11945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G8D25_RS11960	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G8D25_RS11975	COG1408	metallophosphoesterase
G8D25_RS11995	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G8D25_RS12000	COG0706	membrane insertase activity
G8D25_RS12005	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G8D25_RS12010	COG0594	ribonuclease P activity
G8D25_RS12015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G8D25_RS12020	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G8D25_RS12025	COG0592	DNA-directed DNA polymerase activity
G8D25_RS12045	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
G8D25_RS12160	COG3781	membrane
G8D25_RS12185	COG1126	abc transporter atp-binding protein
G8D25_RS12190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS12205	COG0745	RESPONSE REGULATOR receiver
G8D25_RS12210	COG0642	Histidine kinase
G8D25_RS12225	COG2814	Major facilitator Superfamily
G8D25_RS12240	COG1959	2 iron, 2 sulfur cluster binding
G8D25_RS12265	COG0745	RESPONSE REGULATOR receiver
G8D25_RS12270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D25_RS12285	COG1335	isochorismatase
G8D25_RS12290	COG2197	response regulator
G8D25_RS12295	COG2200	EAL domain
G8D25_RS12305	COG2205	protein histidine kinase activity
G8D25_RS12310	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
G8D25_RS12320	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
G8D25_RS12335	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G8D25_RS12350	COG1116	anion transmembrane transporter activity
G8D25_RS12360	COG1254	Belongs to the acylphosphatase family
G8D25_RS12370	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
G8D25_RS12375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D25_RS12380	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
G8D25_RS12385	COG2894	cell division
G8D25_RS12390	COG0850	regulation of cytokinetic process
G8D25_RS12395	COG0737	Belongs to the 5'-nucleotidase family
G8D25_RS12405	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
G8D25_RS12425	COG0642	Histidine kinase
G8D25_RS12440	COG2154	pterin-4-alpha-carbinolamine dehydratase
G8D25_RS12445	COG3186	Phenylalanine-4-hydroxylase
G8D25_RS12460	COG2423	ornithine cyclodeaminase activity
G8D25_RS12485	COG0789	Transcriptional regulator
G8D25_RS12490	COG2267	carboxylic ester hydrolase activity
G8D25_RS12495	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
G8D25_RS12550	COG0583	DNA-binding transcription factor activity
G8D25_RS12555	COG3530	Putative quorum-sensing-regulated virulence factor
G8D25_RS12575	COG0445	tRNA wobble uridine modification
G8D25_RS12580	COG0357	Ribosomal RNA small subunit methyltransferase G
G8D25_RS12585	COG1192	Involved in chromosome partitioning
G8D25_RS12590	COG1475	DNA binding
G8D25_RS12600	COG0356	it plays a direct role in the translocation of protons across the membrane
G8D25_RS12610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G8D25_RS12615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G8D25_RS12620	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G8D25_RS12625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G8D25_RS12630	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G8D25_RS12635	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G8D25_RS12650	COG1832	CoA-binding protein
G8D25_RS12670	COG0625	glutathione transferase activity
G8D25_RS12705	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G8D25_RS12710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G8D25_RS12715	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8D25_RS12715	COG0506	proline dehydrogenase activity
G8D25_RS12715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
G8D25_RS12720	COG0683	leucine binding
G8D25_RS12730	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G8D25_RS12735	COG1297	OPT oligopeptide transporter protein
G8D25_RS12745	COG3220	belongs to the UPF0276 family
G8D25_RS12775	COG1760	l-serine dehydratase
G8D25_RS12780	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8D25_RS12780	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G8D25_RS12785	COG0509	glycine decarboxylation via glycine cleavage system
G8D25_RS12790	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G8D25_RS12805	COG0210	DNA helicase
G8D25_RS12840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8D25_RS12855	COG2084	Dehydrogenase
G8D25_RS12860	COG3622	Belongs to the hyi family
G8D25_RS12865	COG3960	tartronate-semialdehyde synthase activity
G8D25_RS12870	COG0583	DNA-binding transcription factor activity
G8D25_RS12885	COG1739	Uncharacterized protein family UPF0029
G8D25_RS12895	COG1301	dicarboxylic acid transport
G8D25_RS12900	COG4266	Belongs to the allantoicase family
G8D25_RS12910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8D25_RS12935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8D25_RS12950	COG0792	nuclease activity
G8D25_RS12965	COG0446	pyridine nucleotide-disulphide oxidoreductase
G8D25_RS12970	COG0697	spore germination
G8D25_RS12975	COG4654	Cytochrome c, class I
G8D25_RS13000	COG2010	Cytochrome c
G8D25_RS13005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G8D25_RS13010	COG0737	Belongs to the 5'-nucleotidase family
G8D25_RS13055	COG3311	Transcriptional regulator
G8D25_RS13220	COG2916	Histone family protein nucleoid-structuring protein H-NS
G8D25_RS13335	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8D25_RS13390	COG0529	Catalyzes the synthesis of activated sulfate
G8D25_RS13405	COG0457	Tetratricopeptide repeat
G8D25_RS13430	COG0493	'glutamate synthase
G8D25_RS13460	COG1733	regulation of RNA biosynthetic process
G8D25_RS13475	COG0436	Aminotransferase
G8D25_RS13495	COG3483	tryptophan 2,3-dioxygenase activity
G8D25_RS13560	COG4251	negative regulation of phosphorylation
G8D25_RS13560	COG2203	Gaf domain
G8D25_RS13560	COG5001	Diguanylate cyclase
G8D25_RS13560	COG3706	GGDEF domain
G8D25_RS13565	COG0671	phosphoesterase, PA-phosphatase related
G8D25_RS13575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D25_RS13585	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS13595	COG0840	transmembrane signaling receptor activity
G8D25_RS13625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8D25_RS13635	COG3284	Transcriptional regulator
G8D25_RS13640	COG1012	belongs to the aldehyde dehydrogenase family
G8D25_RS13645	COG4303	Ethanolamine ammonia lyase large subunit
G8D25_RS13650	COG4302	ethanolamine ammonia-lyase activity
G8D25_RS13655	COG2925	Exonuclease
G8D25_RS13775	COG1522	sequence-specific DNA binding
G8D25_RS13805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G8D25_RS13805	COG0475	glutathione-regulated potassium exporter activity
G8D25_RS13835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS13845	COG0745	RESPONSE REGULATOR receiver
G8D25_RS13915	COG0789	Transcriptional regulator
G8D25_RS13940	COG0784	Response regulator, receiver
G8D25_RS13940	COG2205	protein histidine kinase activity
G8D25_RS13945	COG2197	response regulator
G8D25_RS13985	COG2814	Major facilitator Superfamily
G8D25_RS13990	COG0668	transmembrane transport
G8D25_RS14010	COG0745	RESPONSE REGULATOR receiver
G8D25_RS14015	COG2205	protein histidine kinase activity
G8D25_RS14040	COG2942	2-epimerase
G8D25_RS14045	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G8D25_RS14070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G8D25_RS14085	COG0395	ABC-type sugar transport system, permease component
G8D25_RS14095	COG3842	ATPase activity
G8D25_RS14110	COG1349	DNA-binding transcription factor activity
G8D25_RS14155	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G8D25_RS14175	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G8D25_RS14180	COG0081	regulation of translation
G8D25_RS14185	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G8D25_RS14190	COG0222	ribosome binding
G8D25_RS14195	COG0085	RNA polymerase activity
G8D25_RS14200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G8D25_RS14205	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
G8D25_RS14210	COG3234	Protein of unknown function (DUF1175)
G8D25_RS14215	COG2373	Large extracellular alpha-helical protein
G8D25_RS14220	COG5445	Predicted secreted protein (DUF2300)
G8D25_RS14225	COG4676	Protein conserved in bacteria
G8D25_RS14230	COG4676	Protein conserved in bacteria
G8D25_RS14240	COG0514	ATP-dependent DNA helicase (RecQ)
G8D25_RS14245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G8D25_RS14250	COG0049	tRNA binding
G8D25_RS14265	COG0051	transcription antitermination factor activity, RNA binding
G8D25_RS14270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G8D25_RS14280	COG0089	rRNA binding
G8D25_RS14285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G8D25_RS14290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G8D25_RS14295	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G8D25_RS14300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G8D25_RS14305	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G8D25_RS14315	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G8D25_RS14320	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G8D25_RS14325	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G8D25_RS14330	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G8D25_RS14335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G8D25_RS14340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G8D25_RS14345	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G8D25_RS14350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G8D25_RS14355	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G8D25_RS14360	COG1841	ribosomal large subunit assembly
G8D25_RS14365	COG0200	Binds to the 23S rRNA
G8D25_RS14370	COG0201	protein transport
G8D25_RS14375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8D25_RS14380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G8D25_RS14385	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G8D25_RS14390	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G8D25_RS14395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G8D25_RS14400	COG0202	RNA polymerase activity
G8D25_RS14405	COG0203	ribosomal protein L17
G8D25_RS14415	COG4232	protein-disulfide reductase activity
G8D25_RS14425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G8D25_RS14440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G8D25_RS14460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
G8D25_RS14465	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
G8D25_RS14480	COG1965	Belongs to the frataxin family
G8D25_RS14520	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G8D25_RS14525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G8D25_RS14530	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G8D25_RS14535	COG3047	cAMP biosynthetic process
G8D25_RS14545	COG0070	glutamate synthase
G8D25_RS14545	COG0069	glutamate synthase activity
G8D25_RS14545	COG0067	glutamate synthase
G8D25_RS14560	COG1127	ABC transporter
G8D25_RS14565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G8D25_RS14570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8D25_RS14590	COG1131	(ABC) transporter
G8D25_RS14595	COG0842	Transport permease protein
G8D25_RS14605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G8D25_RS14610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G8D25_RS14615	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G8D25_RS14620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8D25_RS14625	COG0131	Imidazoleglycerol-phosphate dehydratase
G8D25_RS14630	COG2095	MarC family integral membrane protein
G8D25_RS14635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G8D25_RS14640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G8D25_RS14645	COG0107	imidazoleglycerol-phosphate synthase activity
G8D25_RS14650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G8D25_RS14655	COG0140	phosphoribosyl-ATP diphosphatase activity
G8D25_RS14665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8D25_RS14670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G8D25_RS14675	COG0805	protein transport
G8D25_RS14680	COG3842	ATPase activity
G8D25_RS14695	COG0642	Histidine kinase
G8D25_RS14710	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS14715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D25_RS14720	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G8D25_RS14725	COG1970	mechanosensitive ion channel activity
G8D25_RS14730	COG0723	plastoquinol--plastocyanin reductase activity
G8D25_RS14735	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G8D25_RS14740	COG2857	Cytochrome c1
G8D25_RS14745	COG0625	glutathione transferase activity
G8D25_RS14750	COG2969	positive regulation of protein catabolic process
G8D25_RS14765	COG0596	Alpha beta hydrolase
G8D25_RS14785	COG0405	Gamma-glutamyltransferase
G8D25_RS14790	COG4774	siderophore transport
G8D25_RS14795	COG3712	iron ion homeostasis
G8D25_RS14805	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G8D25_RS14820	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
G8D25_RS14825	COG0488	(ABC) transporter
G8D25_RS14845	COG3416	Protein conserved in bacteria
G8D25_RS14845	COG2943	transferase activity, transferring hexosyl groups
G8D25_RS14850	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
G8D25_RS14865	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
G8D25_RS14870	COG2890	protein-(glutamine-N5) methyltransferase activity
G8D25_RS14880	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G8D25_RS14885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G8D25_RS14895	COG0012	GTP binding
G8D25_RS14920	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G8D25_RS14930	COG0604	alcohol dehydrogenase
G8D25_RS14935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D25_RS14940	COG1289	transmembrane transporter activity
G8D25_RS14955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G8D25_RS14965	COG0134	indole-3-glycerol-phosphate synthase activity
G8D25_RS14970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G8D25_RS14980	COG0512	Glutamine amidotransferase of anthranilate synthase
G8D25_RS14990	COG0546	phosphoglycolate phosphatase activity
G8D25_RS14995	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G8D25_RS15000	COG2967	ApaG domain
G8D25_RS15020	COG2050	protein possibly involved in aromatic compounds catabolism
G8D25_RS15025	COG1024	Enoyl-CoA hydratase
G8D25_RS15030	COG1024	Enoyl-CoA hydratase
G8D25_RS15050	COG1473	amidohydrolase
G8D25_RS15055	COG0747	negative chemotaxis
G8D25_RS15060	COG0601	transmembrane transport
G8D25_RS15065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8D25_RS15075	COG4608	Belongs to the ABC transporter superfamily
G8D25_RS15080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8D25_RS15090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8D25_RS15090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G8D25_RS15095	COG1105	Belongs to the carbohydrate kinase PfkB family
G8D25_RS15100	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
G8D25_RS15100	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G8D25_RS15105	COG1609	Transcriptional regulator
G8D25_RS15110	COG0243	molybdopterin cofactor binding
G8D25_RS15120	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS15125	COG0477	Major facilitator Superfamily
G8D25_RS15130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS15135	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
G8D25_RS15140	COG2001	Belongs to the MraZ family
G8D25_RS15145	COG0275	rRNA processing
G8D25_RS15150	COG3116	cell division
G8D25_RS15160	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G8D25_RS15165	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G8D25_RS15170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G8D25_RS15175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G8D25_RS15185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G8D25_RS15190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G8D25_RS15195	COG1181	Belongs to the D-alanine--D-alanine ligase family
G8D25_RS15200	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G8D25_RS15215	COG0678	peroxiredoxin activity
G8D25_RS15220	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G8D25_RS15230	COG0739	heme binding
G8D25_RS15235	COG0653	protein targeting
G8D25_RS15240	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G8D25_RS15250	COG0494	nUDIX hydrolase
G8D25_RS15255	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G8D25_RS15260	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
G8D25_RS15265	COG0237	dephospho-CoA kinase activity
G8D25_RS15275	COG1459	type II secretion system
G8D25_RS15285	COG4536	flavin adenine dinucleotide binding
G8D25_RS15295	COG0142	geranyltranstransferase activity
G8D25_RS15300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G8D25_RS15305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G8D25_RS15310	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G8D25_RS15315	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G8D25_RS15325	COG0494	nUDIX hydrolase
G8D25_RS15330	COG0442	prolyl-tRNA aminoacylation
G8D25_RS15335	COG0741	lytic transglycosylase activity
G8D25_RS15345	COG2095	MarC family integral membrane protein
G8D25_RS15355	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G8D25_RS15360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G8D25_RS15405	COG1522	sequence-specific DNA binding
G8D25_RS15455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8D25_RS15460	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G8D25_RS15470	COG2264	protein methyltransferase activity
G8D25_RS15480	COG0511	ligase activity, forming carbon-carbon bonds
G8D25_RS15485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G8D25_RS15490	COG3118	belongs to the thioredoxin family
G8D25_RS15505	COG3150	esterase
G8D25_RS15510	COG3161	chorismate lyase activity
G8D25_RS15515	COG0557	exoribonuclease II activity
G8D25_RS15525	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G8D25_RS15530	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G8D25_RS15545	COG0284	orotidine-5'-phosphate decarboxylase activity
G8D25_RS15550	COG1230	cation diffusion facilitator family transporter
G8D25_RS15555	COG1546	Belongs to the CinA family
G8D25_RS15555	COG1058	Belongs to the CinA family
G8D25_RS15560	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G8D25_RS15590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G8D25_RS15600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G8D25_RS15605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G8D25_RS15610	COG0583	DNA-binding transcription factor activity
G8D25_RS15615	COG0735	belongs to the Fur family
G8D25_RS15620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G8D25_RS15625	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G8D25_RS15630	COG0495	leucyl-tRNA aminoacylation
G8D25_RS15640	COG1466	dna polymerase III delta subunit
G8D25_RS15645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G8D25_RS15660	COG2204	response regulator
G8D25_RS15665	COG4191	Histidine kinase
G8D25_RS15670	COG4191	Histidine kinase
G8D25_RS15695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G8D25_RS15715	COG2814	Major facilitator Superfamily
G8D25_RS15735	COG0482	sulfurtransferase activity
G8D25_RS15740	COG0069	glutamate synthase activity
G8D25_RS15745	COG0625	glutathione transferase activity
G8D25_RS15755	COG3038	cytochrome b561
G8D25_RS15760	COG2353	YceI-like domain
G8D25_RS15765	COG2353	YceI-like domain
G8D25_RS15770	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8D25_RS15775	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G8D25_RS15780	COG1862	Preprotein translocase
G8D25_RS15785	COG0343	queuine tRNA-ribosyltransferase activity
G8D25_RS15790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G8D25_RS15795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G8D25_RS15860	COG1522	sequence-specific DNA binding
G8D25_RS15865	COG1473	amidohydrolase
G8D25_RS15875	COG0697	spore germination
G8D25_RS15895	COG0783	Belongs to the Dps family
G8D25_RS15900	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G8D25_RS15960	COG0386	Belongs to the glutathione peroxidase family
G8D25_RS15980	COG1346	cytolysis
G8D25_RS15985	COG1380	Effector of murein hydrolase LrgA
G8D25_RS15990	COG0247	lactate metabolic process
G8D25_RS15995	COG0277	FAD linked oxidase domain protein
G8D25_RS16000	COG0277	FAD linked oxidase domain protein
G8D25_RS16005	COG0277	FAD linked oxidase domain protein
G8D25_RS16010	COG2096	Adenosyltransferase
G8D25_RS16015	COG0668	transmembrane transport
G8D25_RS16025	COG3550	peptidyl-serine autophosphorylation
G8D25_RS16030	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G8D25_RS16040	COG0312	modulator of DNA gyrase
G8D25_RS16045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G8D25_RS16055	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G8D25_RS16065	COG1404	Belongs to the peptidase S8 family
G8D25_RS16070	COG1404	Belongs to the peptidase S8 family
G8D25_RS16080	COG0497	DNA recombination
G8D25_RS16085	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G8D25_RS16090	COG1420	regulation of RNA biosynthetic process
G8D25_RS16100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
G8D25_RS16105	COG2986	histidine ammonia-lyase
G8D25_RS16110	COG0010	Belongs to the arginase family
G8D25_RS16115	COG1228	amidohydrolase
G8D25_RS16120	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G8D25_RS16135	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G8D25_RS16145	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8D25_RS16150	COG0443	Heat shock 70 kDa protein
G8D25_RS16155	COG0484	heat shock protein binding
G8D25_RS16160	COG0512	Glutamine amidotransferase of anthranilate synthase
G8D25_RS16160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G8D25_RS16165	COG1122	ATPase activity
G8D25_RS16170	COG4662	Binding-protein-dependent transport system inner membrane component
G8D25_RS16175	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G8D25_RS16185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G8D25_RS16200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G8D25_RS16205	COG0628	permease
G8D25_RS16210	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G8D25_RS16225	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8D25_RS16225	COG2169	Transcriptional regulator
G8D25_RS16240	COG2169	Transcriptional regulator
G8D25_RS16240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8D25_RS16250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G8D25_RS16255	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G8D25_RS16260	COG3008	intermembrane lipid transfer
G8D25_RS16275	COG0586	Pfam SNARE associated Golgi protein
G8D25_RS16285	COG0728	peptidoglycan biosynthetic process
G8D25_RS16290	COG0268	Binds directly to 16S ribosomal RNA
G8D25_RS16300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G8D25_RS16305	COG0137	argininosuccinate synthase activity
G8D25_RS16310	COG3123	guanosine phosphorylase activity
G8D25_RS16320	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G8D25_RS16325	COG1666	GTP binding
G8D25_RS16335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G8D25_RS16345	COG4974	Belongs to the 'phage' integrase family
G8D25_RS16350	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G8D25_RS16365	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G8D25_RS16370	COG0802	atpase or kinase
G8D25_RS16375	COG0860	N-Acetylmuramoyl-L-alanine amidase
G8D25_RS16385	COG0583	DNA-binding transcription factor activity
G8D25_RS16395	COG0563	adenylate kinase activity
G8D25_RS16400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G8D25_RS16405	COG2835	tetraacyldisaccharide 4'-kinase activity
G8D25_RS16410	COG1663	tetraacyldisaccharide 4'-kinase activity
G8D25_RS16415	COG0848	biopolymer transport protein
G8D25_RS16420	COG0811	peptide transport
G8D25_RS16425	COG1570	exodeoxyribonuclease VII activity
G8D25_RS16430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G8D25_RS16435	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS16475	COG2610	gluconate transmembrane transporter activity
G8D25_RS16550	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS16555	COG2321	neutral zinc metallopeptidase
G8D25_RS16565	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8D25_RS16580	COG2259	Doxx family
G8D25_RS16585	COG0477	Major facilitator Superfamily
G8D25_RS16590	COG0583	DNA-binding transcription factor activity
G8D25_RS16595	COG0583	DNA-binding transcription factor activity
G8D25_RS16635	COG0582	viral genome integration into host DNA
G8D25_RS16705	COG1278	Cold shock
G8D25_RS16710	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
G8D25_RS16715	COG0542	response to heat
G8D25_RS16720	COG0756	dUTP diphosphatase activity
G8D25_RS16725	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D25_RS16730	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G8D25_RS16740	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G8D25_RS16745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G8D25_RS16750	COG0196	riboflavin kinase activity
G8D25_RS16755	COG0784	Response regulator, receiver
G8D25_RS16755	COG5002	protein histidine kinase activity
G8D25_RS16760	COG2197	response regulator
G8D25_RS16765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G8D25_RS16770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G8D25_RS16770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G8D25_RS16780	COG3264	Mechanosensitive ion channel
G8D25_RS16780	COG1511	domain protein
G8D25_RS16790	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G8D25_RS16800	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G8D25_RS16805	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G8D25_RS16810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G8D25_RS16815	COG2003	Belongs to the UPF0758 family
G8D25_RS16820	COG1047	Peptidyl-prolyl cis-trans
G8D25_RS16825	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G8D25_RS16860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G8D25_RS16905	COG2084	Dehydrogenase
G8D25_RS16915	COG0583	DNA-binding transcription factor activity
G8D25_RS16920	COG0730	response to heat
G8D25_RS16925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G8D25_RS16935	COG0175	sulfate reduction
G8D25_RS16945	COG2895	sulfate adenylyltransferase (ATP) activity
G8D25_RS16950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G8D25_RS16950	COG1648	precorrin-2 dehydrogenase activity
G8D25_RS16975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G8D25_RS16990	COG0129	dihydroxy-acid dehydratase activity
G8D25_RS16995	COG0583	DNA-binding transcription factor activity
G8D25_RS17000	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G8D25_RS17030	COG4206	TonB-dependent receptor
G8D25_RS17040	COG1120	ATPase activity
G8D25_RS17050	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G8D25_RS17055	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G8D25_RS17075	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G8D25_RS17085	COG1492	cobalamin metabolic process
G8D25_RS17095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G8D25_RS17100	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
G8D25_RS17115	COG2911	Protein conserved in bacteria
G8D25_RS17125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8D25_RS17125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8D25_RS17130	COG2885	chlorophyll binding
G8D25_RS17130	COG3047	cAMP biosynthetic process
G8D25_RS17135	COG0489	protein tyrosine kinase activity
G8D25_RS17165	COG3383	formate dehydrogenase (NAD+) activity
G8D25_RS17165	COG0243	molybdopterin cofactor binding
G8D25_RS17170	COG0437	4 iron, 4 sulfur cluster binding
G8D25_RS17190	COG2032	superoxide dismutase activity
G8D25_RS17195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G8D25_RS17200	COG0717	Belongs to the dCTP deaminase family
G8D25_RS17205	COG1982	Orn Lys Arg decarboxylase major
G8D25_RS17225	COG1857	crispr-associated protein
G8D25_RS17240	COG1518	maintenance of DNA repeat elements
G8D25_RS17245	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8D25_RS17250	COG0165	Argininosuccinate lyase
G8D25_RS17280	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G8D25_RS17285	COG0181	hydroxymethylbilane synthase activity
G8D25_RS17310	COG2271	Major facilitator Superfamily
G8D25_RS17325	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G8D25_RS17365	COG0492	ferredoxin-NADP+ reductase activity
G8D25_RS17375	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
G8D25_RS17390	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G8D25_RS17410	COG2197	response regulator
G8D25_RS17575	COG0789	Transcriptional regulator
G8D25_RS17580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8D25_RS17585	COG1253	flavin adenine dinucleotide binding
G8D25_RS17625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS17640	COG0765	amino acid transport
G8D25_RS17645	COG0765	amino acid transport
G8D25_RS17650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS17660	COG1414	Transcriptional regulator
G8D25_RS17670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
G8D25_RS17675	COG0183	Belongs to the thiolase family
G8D25_RS17685	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G8D25_RS17690	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8D25_RS17705	COG0411	ABC transporter
G8D25_RS17710	COG0410	ABC transporter
G8D25_RS17715	COG0683	leucine binding
G8D25_RS17730	COG2342	PFAM TM1410 hypothetical-related protein
G8D25_RS17740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G8D25_RS17755	COG0525	valine-tRNA ligase activity
G8D25_RS17760	COG0210	DNA helicase
G8D25_RS17770	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
G8D25_RS17780	COG1611	Belongs to the LOG family
G8D25_RS17785	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8D25_RS17785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G8D25_RS17790	COG1252	NADH dehydrogenase
G8D25_RS17795	COG0412	Dienelactone hydrolase
G8D25_RS17825	COG1722	exodeoxyribonuclease VII activity
G8D25_RS17830	COG0142	geranyltranstransferase activity
G8D25_RS17835	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G8D25_RS17840	COG1469	GTP cyclohydrolase I activity
G8D25_RS17845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G8D25_RS17850	COG2081	HI0933 family
G8D25_RS17855	COG1610	YqeY-like protein
G8D25_RS17885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8D25_RS17885	COG0426	domain, Protein
G8D25_RS17890	COG0513	Belongs to the DEAD box helicase family
G8D25_RS17895	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8D25_RS17900	COG0583	DNA-binding transcription factor activity
G8D25_RS17905	COG1741	Belongs to the pirin family
G8D25_RS17950	COG1132	(ABC) transporter
G8D25_RS17970	COG1530	ribonuclease E activity
G8D25_RS17975	COG0424	maF-like protein
G8D25_RS17980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G8D25_RS17985	COG0799	negative regulation of ribosome biogenesis
G8D25_RS17995	COG0408	coproporphyrinogen oxidase activity
G8D25_RS18000	COG0151	Belongs to the GarS family
G8D25_RS18005	COG0217	transcriptional regulatory protein
G8D25_RS18010	COG0433	COG0433 Predicted ATPase
G8D25_RS18015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G8D25_RS18020	COG0697	spore germination
G8D25_RS18025	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS18030	COG1803	Methylglyoxal synthase
G8D25_RS18045	COG1335	isochorismatase
G8D25_RS18050	COG2814	Major facilitator Superfamily
G8D25_RS18100	COG1129	ABC transporter
G8D25_RS18105	COG2814	Major facilitator Superfamily
G8D25_RS18110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G8D25_RS18115	COG1984	allophanate hydrolase subunit 2
G8D25_RS18120	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G8D25_RS18135	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
G8D25_RS18140	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
G8D25_RS18180	COG0582	viral genome integration into host DNA
G8D25_RS18245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G8D25_RS18250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G8D25_RS18255	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G8D25_RS18270	COG1561	YicC-like family, N-terminal region
G8D25_RS18275	COG0194	GDP metabolic process
G8D25_RS18280	COG1758	RNA polymerase activity
G8D25_RS18315	COG1652	LysM domain
G8D25_RS18330	COG0308	aminopeptidase N
G8D25_RS18350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS18370	COG2233	PERMEase
G8D25_RS18380	COG2351	hydroxyisourate hydrolase activity
G8D25_RS18395	COG0583	DNA-binding transcription factor activity
G8D25_RS18400	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
G8D25_RS18425	COG1064	alcohol dehydrogenase
G8D25_RS18440	COG0583	DNA-binding transcription factor activity
G8D25_RS18450	COG2119	membrane
G8D25_RS18455	COG0402	S-adenosylhomocysteine deaminase activity
G8D25_RS18470	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G8D25_RS18495	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
G8D25_RS18520	COG1309	transcriptional regulator
G8D25_RS18530	COG0438	transferase activity, transferring glycosyl groups
G8D25_RS18565	COG0028	Belongs to the TPP enzyme family
G8D25_RS18575	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G8D25_RS18580	COG0688	phosphatidylethanolamine metabolic process
G8D25_RS18585	COG1183	phosphatidylcholine synthase activity
G8D25_RS18590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G8D25_RS18605	COG0683	leucine binding
G8D25_RS18610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G8D25_RS18615	COG1185	polyribonucleotide nucleotidyltransferase activity
G8D25_RS18625	COG1063	alcohol dehydrogenase
G8D25_RS18630	COG0149	triose-phosphate isomerase activity
G8D25_RS18650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8D25_RS18655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8D25_RS18660	COG0649	NAD binding
G8D25_RS18675	COG1034	ATP synthesis coupled electron transport
G8D25_RS18680	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G8D25_RS18685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G8D25_RS18695	COG0713	ATP synthesis coupled electron transport
G8D25_RS18710	COG1007	ATP synthesis coupled electron transport
G8D25_RS18730	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS18735	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS18740	COG2030	dehydratase
G8D25_RS18740	COG1012	belongs to the aldehyde dehydrogenase family
G8D25_RS18775	COG0829	nickel cation binding
G8D25_RS18780	COG0831	urea catabolic process
G8D25_RS18790	COG0832	Belongs to the urease beta subunit family
G8D25_RS18800	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
G8D25_RS18805	COG0830	nickel cation binding
G8D25_RS18810	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G8D25_RS18835	COG0625	glutathione transferase activity
G8D25_RS18855	COG0583	DNA-binding transcription factor activity
G8D25_RS18875	COG1024	Enoyl-CoA hydratase
G8D25_RS18880	COG1250	3-hydroxyacyl-CoA dehydrogenase
G8D25_RS18885	COG0625	glutathione transferase activity
G8D25_RS18890	COG0436	Aminotransferase
G8D25_RS18900	COG3022	response to hydroperoxide
G8D25_RS18905	COG2866	Carboxypeptidase
G8D25_RS18915	COG0747	negative chemotaxis
G8D25_RS18930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G8D25_RS18970	COG0039	L-malate dehydrogenase activity
G8D25_RS18975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8D25_RS18985	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
G8D25_RS18990	COG1053	succinate dehydrogenase
G8D25_RS18995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G8D25_RS19000	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
G8D25_RS19005	COG0372	Belongs to the citrate synthase family
G8D25_RS19010	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G8D25_RS19015	COG0066	3-isopropylmalate dehydratase activity
G8D25_RS19020	COG0473	3-isopropylmalate dehydrogenase activity
G8D25_RS19040	COG0101	tRNA pseudouridine synthase activity
G8D25_RS19045	COG0135	phosphoribosylanthranilate isomerase activity
G8D25_RS19050	COG0133	tryptophan synthase activity
G8D25_RS19060	COG0159	tryptophan synthase activity
G8D25_RS19065	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G8D25_RS19070	COG0285	dihydrofolate synthase activity
G8D25_RS19090	COG0842	Transport permease protein
G8D25_RS19125	COG3193	protein, possibly involved in utilization of glycolate and propanediol
G8D25_RS19170	COG1301	dicarboxylic acid transport
G8D25_RS19175	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G8D25_RS19190	COG0697	spore germination
G8D25_RS19195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D25_RS19200	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G8D25_RS19220	COG2197	response regulator
G8D25_RS19230	COG0840	transmembrane signaling receptor activity
G8D25_RS19270	COG0747	negative chemotaxis
G8D25_RS19275	COG4608	Belongs to the ABC transporter superfamily
G8D25_RS19280	COG0444	Belongs to the ABC transporter superfamily
G8D25_RS19290	COG0601	transmembrane transport
G8D25_RS19340	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
G8D25_RS19375	COG2801	Transposase and inactivated derivatives
G8D25_RS19555	COG0778	Nitroreductase
G8D25_RS19560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G8D25_RS19565	COG2878	Part of a membrane complex involved in electron transport
G8D25_RS19570	COG1309	transcriptional regulator
G8D25_RS19590	COG0556	nucleotide-excision repair
G8D25_RS19600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G8D25_RS19605	COG1609	Transcriptional regulator
G8D25_RS19610	COG1172	Belongs to the binding-protein-dependent transport system permease family
G8D25_RS19615	COG1129	ABC transporter
G8D25_RS19620	COG1879	ABC-type sugar transport system periplasmic component
G8D25_RS19630	COG1104	cysteine desulfurase activity
G8D25_RS19635	COG0822	iron-sulfur transferase activity
G8D25_RS19650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G8D25_RS19655	COG0443	Heat shock 70 kDa protein
G8D25_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS19690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G8D25_RS19705	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G8D25_RS19725	COG0746	molybdenum cofactor guanylyltransferase activity
G8D25_RS19730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G8D25_RS19735	COG1530	ribonuclease E activity
G8D25_RS19745	COG0546	phosphoglycolate phosphatase activity
G8D25_RS19765	COG0424	maF-like protein
G8D25_RS19770	COG1399	metal-binding, possibly nucleic acid-binding protein
G8D25_RS19775	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G8D25_RS19780	COG0416	fatty acid biosynthetic process
G8D25_RS19785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G8D25_RS19795	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS19800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G8D25_RS19805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G8D25_RS19830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G8D25_RS19840	COG0481	GTPase activity
G8D25_RS19845	COG0681	Belongs to the peptidase S26 family
G8D25_RS19855	COG0571	ribonuclease III activity
G8D25_RS19860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G8D25_RS19865	COG1381	Involved in DNA repair and RecF pathway recombination
G8D25_RS19870	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G8D25_RS19875	COG0736	holo-[acyl-carrier-protein] synthase activity
G8D25_RS19885	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G8D25_RS19895	COG0322	excinuclease ABC activity
G8D25_RS19925	COG0745	RESPONSE REGULATOR receiver
G8D25_RS19935	COG5002	protein histidine kinase activity
G8D25_RS19940	COG0745	RESPONSE REGULATOR receiver
G8D25_RS19950	COG2186	Transcriptional regulator
G8D25_RS19960	COG2271	Major facilitator Superfamily
G8D25_RS19970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS19980	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
G8D25_RS20030	COG0583	DNA-binding transcription factor activity
G8D25_RS20050	COG2124	cytochrome p450
G8D25_RS20075	COG0583	DNA-binding transcription factor activity
G8D25_RS20080	COG2855	membrane
G8D25_RS20105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
G8D25_RS20110	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G8D25_RS20125	COG1136	(ABC) transporter
G8D25_RS20130	COG0084	hydrolase, TatD family'
G8D25_RS20140	COG2308	Evidence 4 Homologs of previously reported genes of
G8D25_RS20160	COG2267	carboxylic ester hydrolase activity
G8D25_RS20165	COG0504	CTP synthase activity
G8D25_RS20170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G8D25_RS20180	COG0148	phosphopyruvate hydratase activity
G8D25_RS20185	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
G8D25_RS20195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G8D25_RS20205	COG2833	Protein of unknown function (DUF455)
G8D25_RS20210	COG2267	carboxylic ester hydrolase activity
G8D25_RS20215	COG3011	Protein conserved in bacteria
G8D25_RS20230	COG0492	ferredoxin-NADP+ reductase activity
G8D25_RS20235	COG0613	PHP domain protein
G8D25_RS20240	COG0009	L-threonylcarbamoyladenylate synthase
G8D25_RS20245	COG1994	Peptidase M50
G8D25_RS20250	COG0180	Tryptophanyl-tRNA synthetase
G8D25_RS20255	COG2226	methyltransferase
G8D25_RS20260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G8D25_RS20265	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
G8D25_RS20270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8D25_RS20280	COG2850	peptidyl-arginine hydroxylation
G8D25_RS20295	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G8D25_RS20300	COG0583	DNA-binding transcription factor activity
G8D25_RS20310	COG0656	L-ascorbic acid biosynthetic process
G8D25_RS20325	COG2258	MOSC domain
G8D25_RS20350	COG1045	serine acetyltransferase
G8D25_RS20355	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D25_RS20380	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
G8D25_RS20385	COG0825	malonyl-CoA metabolic process
G8D25_RS20390	COG0037	tRNA processing
G8D25_RS20395	COG0527	aspartate kinase activity
G8D25_RS20410	COG4166	transmembrane transport
G8D25_RS20420	COG4239	(ABC) transporter, permease
G8D25_RS20425	COG4172	Belongs to the ABC transporter superfamily
G8D25_RS20430	COG0791	NLP P60 protein
G8D25_RS20435	COG1752	Esterase of the alpha-beta hydrolase superfamily
G8D25_RS20440	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G8D25_RS20475	COG0534	Mate efflux family protein
G8D25_RS20485	COG0254	rRNA binding
G8D25_RS20495	COG2197	response regulator
G8D25_RS20535	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G8D25_RS20540	COG2329	Antibiotic biosynthesis monooxygenase
G8D25_RS20580	COG1309	transcriptional regulator
G8D25_RS20595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G8D25_RS20625	COG0670	Belongs to the BI1 family
G8D25_RS20630	COG0105	UTP biosynthetic process
G8D25_RS20635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G8D25_RS20650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G8D25_RS20670	COG1160	GTP binding
G8D25_RS20675	COG1923	regulation of RNA biosynthetic process
G8D25_RS20680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G8D25_RS20685	COG0330	HflC and HflK could
G8D25_RS20690	COG0330	HflC and HflK could
G8D25_RS20700	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G8D25_RS20705	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G8D25_RS20710	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G8D25_RS20720	COG0557	exoribonuclease II activity
G8D25_RS20725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8D25_RS20730	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G8D25_RS20735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G8D25_RS20745	COG1953	Uracil, thiamine, allantoin
G8D25_RS20760	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
G8D25_RS20765	COG0673	inositol 2-dehydrogenase activity
G8D25_RS20770	COG1737	Transcriptional regulator
G8D25_RS20820	COG1129	ABC transporter
G8D25_RS20825	COG4211	Belongs to the binding-protein-dependent transport system permease family
G8D25_RS20835	COG3962	Belongs to the TPP enzyme family
G8D25_RS20845	COG3718	enzyme involved in inositol metabolism
G8D25_RS20850	COG1082	Xylose isomerase domain protein TIM barrel
G8D25_RS20855	COG0673	inositol 2-dehydrogenase activity
G8D25_RS20890	COG1058	Belongs to the CinA family
G8D25_RS20890	COG1546	Belongs to the CinA family
G8D25_RS20900	COG0174	glutamine synthetase
G8D25_RS20915	COG2204	response regulator
G8D25_RS20925	COG2217	Heavy metal translocating P-type atpase
G8D25_RS20930	COG1653	transport
G8D25_RS20935	COG1175	transmembrane transport
G8D25_RS20940	COG0395	ABC-type sugar transport system, permease component
G8D25_RS20945	COG3842	ATPase activity
G8D25_RS20950	COG0584	glycerophosphoryl diester phosphodiesterase
G8D25_RS20960	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8D25_RS20965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8D25_RS20970	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G8D25_RS20980	COG2217	Heavy metal translocating P-type atpase
G8D25_RS20990	COG3278	Belongs to the heme-copper respiratory oxidase family
G8D25_RS21025	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
G8D25_RS21035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G8D25_RS21045	COG0779	Required for maturation of 30S ribosomal subunits
G8D25_RS21050	COG2251	uridine kinase activity
G8D25_RS21050	COG0195	Participates in both transcription termination and antitermination
G8D25_RS21055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G8D25_RS21060	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G8D25_RS21090	COG1024	Enoyl-CoA hydratase
G8D25_RS21095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8D25_RS21110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8D25_RS21125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
G8D25_RS21140	COG0360	Binds together with S18 to 16S ribosomal RNA
G8D25_RS21150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G8D25_RS21155	COG0359	binds to the 23S rRNA
G8D25_RS21160	COG0305	Participates in initiation and elongation during chromosome replication
G8D25_RS21170	COG0306	phosphate transporter
G8D25_RS21185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G8D25_RS21190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G8D25_RS21195	COG0726	polysaccharide deacetylase
G8D25_RS21200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D25_RS21200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G8D25_RS21215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G8D25_RS21220	COG2076	Multidrug Resistance protein
G8D25_RS21225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G8D25_RS21235	COG0436	Aminotransferase
G8D25_RS21250	COG1573	uracil-dna glycosylase
G8D25_RS21255	COG0303	'Molybdopterin
G8D25_RS21260	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
G8D25_RS21265	COG0314	molybdopterin synthase activity
G8D25_RS21270	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G8D25_RS21280	COG0542	response to heat
G8D25_RS21285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G8D25_RS21290	COG0431	NADPH-dependent FMN reductase
G8D25_RS21295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D25_RS21300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G8D25_RS21305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G8D25_RS21310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G8D25_RS21315	COG1116	anion transmembrane transporter activity
G8D25_RS21335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
G8D25_RS21340	COG4208	sulfate ABC transporter
G8D25_RS21345	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8D25_RS21350	COG0583	DNA-binding transcription factor activity
G8D25_RS21365	COG3275	phosphorelay sensor kinase activity
G8D25_RS21380	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G8D25_RS21400	COG2224	Isocitrate lyase
G8D25_RS21410	COG0583	DNA-binding transcription factor activity
G8D25_RS21425	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G8D25_RS21440	COG1214	PFAM Peptidase M22, glycoprotease
G8D25_RS21445	COG0456	acetyltransferase
G8D25_RS21450	COG1573	uracil-dna glycosylase
G8D25_RS21455	COG0477	Major facilitator Superfamily
G8D25_RS21460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G8D25_RS21470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G8D25_RS21475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G8D25_RS21480	COG0488	(ABC) transporter
G8D25_RS21490	COG1446	asparaginase
G8D25_RS21495	COG4172	Belongs to the ABC transporter superfamily
G8D25_RS21500	COG0747	negative chemotaxis
G8D25_RS21510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G8D25_RS21550	COG2890	protein-(glutamine-N5) methyltransferase activity
G8D25_RS21560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G8D25_RS21565	COG1393	Belongs to the ArsC family
G8D25_RS21575	COG2171	N-acyltransferase activity
G8D25_RS21590	COG0596	Alpha beta hydrolase
G8D25_RS21605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G8D25_RS21610	COG0242	peptide deformylase activity
G8D25_RS21620	COG1187	pseudouridine synthase activity
G8D25_RS21625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G8D25_RS21630	COG0024	Methionine aminopeptidase
G8D25_RS21635	COG0052	Belongs to the universal ribosomal protein uS2 family
G8D25_RS21640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G8D25_RS21645	COG0528	UMP kinase activity
G8D25_RS21650	COG0233	cytoplasmic translational termination
G8D25_RS21660	COG0575	Belongs to the CDS family
G8D25_RS21665	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G8D25_RS21670	COG0750	zinc metalloprotease
G8D25_RS21685	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D25_RS21690	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G8D25_RS21695	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D25_RS21700	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G8D25_RS21705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G8D25_RS21710	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G8D25_RS21730	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
G8D25_RS21745	COG0330	HflC and HflK could
G8D25_RS21750	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G8D25_RS21755	COG2867	negative regulation of translational initiation
G8D25_RS21760	COG2914	Belongs to the UPF0125 (RnfH) family
G8D25_RS21770	COG0697	spore germination
G8D25_RS21785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G8D25_RS21785	COG0519	Catalyzes the synthesis of GMP from XMP
G8D25_RS21815	COG0583	DNA-binding transcription factor activity
G8D25_RS21820	COG3485	protocatechuate 3,4-dioxygenase
G8D25_RS21825	COG3485	protocatechuate 3,4-dioxygenase
G8D25_RS21845	COG0583	DNA-binding transcription factor activity
G8D25_RS21855	COG3550	peptidyl-serine autophosphorylation
G8D25_RS21865	COG0602	queuosine metabolic process
G8D25_RS21870	COG0720	synthase
G8D25_RS21880	COG1619	proteins homologs of microcin C7 resistance protein MccF
G8D25_RS21885	COG0488	(ABC) transporter
G8D25_RS21905	COG3387	PFAM Glycoside hydrolase 15-related
G8D25_RS21915	COG0840	transmembrane signaling receptor activity
G8D25_RS21930	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
G8D25_RS21970	COG3045	CreA protein
G8D25_RS21975	COG0583	DNA-binding transcription factor activity
G8D25_RS22005	COG0778	Nitroreductase
G8D25_RS22020	COG0583	DNA-binding transcription factor activity
G8D25_RS22025	COG4948	Mandelate Racemase Muconate Lactonizing
G8D25_RS22040	COG4638	Rieske (2fe-2S)
G8D25_RS22045	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
G8D25_RS22050	COG0543	2 iron, 2 sulfur cluster binding
G8D25_RS22050	COG0633	Ferredoxin
G8D25_RS22055	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS22080	COG0156	8-amino-7-oxononanoate synthase activity
G8D25_RS22085	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G8D25_RS22100	COG3739	integral membrane protein
G8D25_RS22120	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G8D25_RS22200	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G8D25_RS22205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G8D25_RS22210	COG4208	sulfate ABC transporter
G8D25_RS22220	COG1840	ABC-type Fe3 transport system, periplasmic component
G8D25_RS22225	COG1609	Transcriptional regulator
G8D25_RS22230	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8D25_RS22245	COG0084	hydrolase, TatD family'
G8D25_RS22255	COG0470	DNA polymerase III
G8D25_RS22260	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G8D25_RS22265	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G8D25_RS22310	COG0596	Alpha beta hydrolase
G8D25_RS22330	COG2130	NADP-dependent
G8D25_RS22345	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS22350	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS22360	COG1335	isochorismatase
G8D25_RS22370	COG0833	amino acid
G8D25_RS22375	COG0833	amino acid
G8D25_RS22410	COG0318	PFAM AMP-dependent synthetase and ligase
G8D25_RS22415	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
G8D25_RS22420	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G8D25_RS22425	COG2917	probably involved in intracellular septation
G8D25_RS22435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8D25_RS22450	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G8D25_RS22465	COG0642	Histidine kinase
G8D25_RS22470	COG3842	ATPase activity
G8D25_RS22480	COG1176	ABC-type spermidine putrescine transport system, permease component I
G8D25_RS22485	COG1177	transmembrane transport
G8D25_RS22490	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS22495	COG0583	DNA-binding transcription factor activity
G8D25_RS22500	COG0535	radical SAM domain protein
G8D25_RS22520	COG0047	phosphoribosylformylglycinamidine synthase activity
G8D25_RS22520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G8D25_RS22530	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G8D25_RS22535	COG0166	Belongs to the GPI family
G8D25_RS22540	COG4181	ATPase activity
G8D25_RS22550	COG0681	Belongs to the peptidase S26 family
G8D25_RS22555	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G8D25_RS22575	COG0776	regulation of translation
G8D25_RS22580	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G8D25_RS22585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G8D25_RS22590	COG0740	serine-type endopeptidase activity
G8D25_RS22595	COG0544	peptidyl-prolyl cis-trans isomerase activity
G8D25_RS22600	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G8D25_RS22600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS22635	COG1562	ergosterol biosynthetic process
G8D25_RS22655	COG0745	RESPONSE REGULATOR receiver
G8D25_RS22660	COG2205	protein histidine kinase activity
G8D25_RS22665	COG0450	alkyl hydroperoxide reductase
G8D25_RS22670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8D25_RS22675	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G8D25_RS22680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G8D25_RS22685	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G8D25_RS22695	COG0560	Phosphoserine phosphatase
G8D25_RS22715	COG0183	Belongs to the thiolase family
G8D25_RS22720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G8D25_RS22725	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G8D25_RS22735	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS22740	COG0183	Belongs to the thiolase family
G8D25_RS22745	COG3243	poly(R)-hydroxyalkanoic acid synthase
G8D25_RS22760	COG0564	pseudouridine synthase activity
G8D25_RS22770	COG1199	ATP-dependent helicase activity
G8D25_RS22785	COG2183	response to ionizing radiation
G8D25_RS22810	COG0167	dihydroorotate dehydrogenase activity
G8D25_RS22825	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
G8D25_RS22830	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
G8D25_RS22860	COG1414	Transcriptional regulator
G8D25_RS22875	COG0824	Thioesterase
G8D25_RS22885	COG0123	including yeast histone deacetylase and acetoin utilization protein
G8D25_RS22900	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G8D25_RS22910	COG0508	dehydrogenase complex catalyzes the overall conversion of
G8D25_RS22915	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G8D25_RS22925	COG4566	intracellular signal transduction
G8D25_RS22930	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G8D25_RS22935	COG0339	signal peptide processing
G8D25_RS22940	COG0402	S-adenosylhomocysteine deaminase activity
G8D25_RS22950	COG1846	Transcriptional regulator
G8D25_RS22970	COG0531	amino acid
G8D25_RS22975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G8D25_RS22990	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G8D25_RS22995	COG4977	sequence-specific DNA binding
G8D25_RS23010	COG0776	regulation of translation
G8D25_RS23015	COG0072	phenylalanine-tRNA ligase activity
G8D25_RS23015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G8D25_RS23020	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G8D25_RS23025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G8D25_RS23030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G8D25_RS23035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G8D25_RS23040	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G8D25_RS23050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G8D25_RS23055	COG0251	oxidation-reduction process
G8D25_RS23065	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS23080	COG4566	intracellular signal transduction
G8D25_RS23085	COG1028	Short-chain dehydrogenase reductase Sdr
G8D25_RS23095	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G8D25_RS23100	COG0545	Peptidyl-prolyl cis-trans isomerase
G8D25_RS23105	COG0477	Major facilitator Superfamily
G8D25_RS23120	COG2267	carboxylic ester hydrolase activity
G8D25_RS23130	COG1295	ribonuclease BN
G8D25_RS23145	COG0277	FAD linked oxidase domain protein
G8D25_RS23190	COG1309	transcriptional regulator
G8D25_RS23195	COG1538	Outer membrane efflux protein
G8D25_RS23210	COG1408	metallophosphoesterase
G8D25_RS23245	COG3008	intermembrane lipid transfer
G8D25_RS23245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G8D25_RS23260	COG2197	response regulator
G8D25_RS23285	COG0589	response to stress
G8D25_RS23290	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G8D25_RS23300	COG0589	response to stress
G8D25_RS23305	COG5001	Diguanylate cyclase
G8D25_RS23305	COG3300	MHYT domain
G8D25_RS23315	COG0640	Transcriptional regulator
G8D25_RS23325	COG0730	response to heat
G8D25_RS23360	COG0248	Ppx GppA phosphatase
G8D25_RS23365	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G8D25_RS23375	COG0745	RESPONSE REGULATOR receiver
G8D25_RS23385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G8D25_RS23390	COG0581	inorganic phosphate transmembrane transporter activity
G8D25_RS23395	COG0573	inorganic phosphate transmembrane transporter activity
G8D25_RS23400	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
G8D25_RS23405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G8D25_RS23410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G8D25_RS23415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G8D25_RS23420	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G8D25_RS23425	COG1534	Rna-binding protein
G8D25_RS23435	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G8D25_RS23450	COG0505	Belongs to the CarA family
G8D25_RS23455	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G8D25_RS23460	COG1388	LysM domain
G8D25_RS23460	COG0741	lytic transglycosylase activity
G8D25_RS23465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G8D25_RS23470	COG2226	methyltransferase
G8D25_RS23475	COG0328	RNA-DNA hybrid ribonuclease activity
G8D25_RS23510	COG0589	response to stress
G8D25_RS23525	COG2304	oxidoreductase activity
G8D25_RS23570	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G8D25_RS23655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8D25_RS23660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G8D25_RS23665	COG0697	spore germination
G8D25_RS23675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G8D25_RS23680	COG0625	glutathione transferase activity
G8D25_RS23700	COG1620	l-lactate permease
G8D25_RS23740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G8D25_RS23770	COG0513	Belongs to the DEAD box helicase family
G8D25_RS23775	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G8D25_RS23785	COG0861	Integral membrane protein TerC family
G8D25_RS23795	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G8D25_RS23805	COG0312	modulator of DNA gyrase
G8D25_RS23810	COG3028	Belongs to the UPF0307 family
G8D25_RS23815	COG0521	Mo-molybdopterin cofactor biosynthetic process
G8D25_RS23820	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G8D25_RS23825	COG0501	Belongs to the peptidase M48B family
G8D25_RS23830	COG1162	GTPase activity
G8D25_RS23840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G8D25_RS23850	COG0335	large ribosomal subunit rRNA binding
G8D25_RS23855	COG0336	Belongs to the RNA methyltransferase TrmD family
G8D25_RS23860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G8D25_RS23865	COG0228	four-way junction DNA binding
G8D25_RS23900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G8D25_RS23905	COG1960	acyl-CoA dehydrogenase activity
G8D25_RS23925	COG2011	ABC-type metal ion transport system permease component
G8D25_RS23930	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G8D25_RS23935	COG0123	including yeast histone deacetylase and acetoin utilization protein
G8D25_RS23940	COG2951	lytic endotransglycosylase activity
G8D25_RS23955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G8D25_RS23960	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G8D25_RS23970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
G8D25_RS23980	COG0776	regulation of translation
G8D25_RS23990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G8D25_RS23995	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G8D25_RS24000	COG0287	Prephenate dehydrogenase
G8D25_RS24005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G8D25_RS24015	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G8D25_RS24040	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G8D25_RS24120	COG0583	DNA-binding transcription factor activity