locus-tag	class	description
BC350_RS00010	COG3962	Belongs to the TPP enzyme family
BC350_RS00020	COG3718	enzyme involved in inositol metabolism
BC350_RS00030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BC350_RS00040	COG1953	Uracil, thiamine, allantoin
BC350_RS00045	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BC350_RS00050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BC350_RS00055	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BC350_RS00060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC350_RS00065	COG0557	exoribonuclease II activity
BC350_RS00075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
BC350_RS00080	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BC350_RS00085	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BC350_RS00095	COG0330	HflC and HflK could
BC350_RS00100	COG0330	HflC and HflK could
BC350_RS00105	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BC350_RS00110	COG1923	regulation of RNA biosynthetic process
BC350_RS00115	COG1160	GTP binding
BC350_RS00125	COG2976	Protein conserved in bacteria
BC350_RS00130	COG0124	histidyl-tRNA synthetase
BC350_RS00135	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BC350_RS00150	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BC350_RS00155	COG0105	UTP biosynthetic process
BC350_RS00165	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BC350_RS00185	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BC350_RS00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BC350_RS00195	COG3321	synthase
BC350_RS00195	COG0604	alcohol dehydrogenase
BC350_RS00195	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS00200	COG1902	pentaerythritol trinitrate reductase activity
BC350_RS00205	COG1309	transcriptional regulator
BC350_RS00210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC350_RS00220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC350_RS00225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC350_RS00240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BC350_RS00245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BC350_RS00275	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BC350_RS00285	COG2197	response regulator
BC350_RS00290	COG3228	Belongs to the MtfA family
BC350_RS00300	COG0254	rRNA binding
BC350_RS00310	COG0534	Mate efflux family protein
BC350_RS00345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC350_RS00350	COG1752	Esterase of the alpha-beta hydrolase superfamily
BC350_RS00355	COG3385	transposase activity
BC350_RS00360	COG0791	NLP P60 protein
BC350_RS00365	COG4172	Belongs to the ABC transporter superfamily
BC350_RS00370	COG4239	(ABC) transporter, permease
BC350_RS00375	COG4174	ABC transporter (Permease)
BC350_RS00380	COG4166	transmembrane transport
BC350_RS00395	COG0527	aspartate kinase activity
BC350_RS00400	COG0037	tRNA processing
BC350_RS00405	COG0825	malonyl-CoA metabolic process
BC350_RS00410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BC350_RS00415	COG0215	cysteine-tRNA ligase activity
BC350_RS00430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BC350_RS00435	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC350_RS00440	COG1045	serine acetyltransferase
BC350_RS00450	COG0483	inositol monophosphate 1-phosphatase activity
BC350_RS00455	COG1396	sequence-specific DNA binding
BC350_RS00465	COG2258	MOSC domain
BC350_RS00475	COG0840	transmembrane signaling receptor activity
BC350_RS00485	COG2814	Major facilitator Superfamily
BC350_RS00490	COG0583	DNA-binding transcription factor activity
BC350_RS00495	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BC350_RS00510	COG2850	peptidyl-arginine hydroxylation
BC350_RS00520	COG1234	tRNA 3'-trailer cleavage
BC350_RS00525	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
BC350_RS00530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC350_RS00540	COG0180	Tryptophanyl-tRNA synthetase
BC350_RS00545	COG1994	Peptidase M50
BC350_RS00550	COG0009	L-threonylcarbamoyladenylate synthase
BC350_RS00555	COG0613	PHP domain protein
BC350_RS00560	COG0492	ferredoxin-NADP+ reductase activity
BC350_RS00575	COG3011	Protein conserved in bacteria
BC350_RS00580	COG2267	carboxylic ester hydrolase activity
BC350_RS00585	COG2833	Protein of unknown function (DUF455)
BC350_RS00595	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BC350_RS00605	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BC350_RS00610	COG0148	phosphopyruvate hydratase activity
BC350_RS00620	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BC350_RS00625	COG0504	CTP synthase activity
BC350_RS00630	COG2267	carboxylic ester hydrolase activity
BC350_RS00650	COG2308	Evidence 4 Homologs of previously reported genes of
BC350_RS00660	COG0084	hydrolase, TatD family'
BC350_RS00665	COG1136	(ABC) transporter
BC350_RS00680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BC350_RS00685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BC350_RS00710	COG2855	membrane
BC350_RS00755	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC350_RS00755	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC350_RS00785	COG0436	Aminotransferase
BC350_RS00795	COG0583	DNA-binding transcription factor activity
BC350_RS00840	COG0625	glutathione transferase activity
BC350_RS00845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS00855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS00865	COG2271	Major facilitator Superfamily
BC350_RS00875	COG2186	Transcriptional regulator
BC350_RS00880	COG3385	transposase activity
BC350_RS00890	COG0745	RESPONSE REGULATOR receiver
BC350_RS00900	COG5002	protein histidine kinase activity
BC350_RS00910	COG0745	RESPONSE REGULATOR receiver
BC350_RS00940	COG0322	excinuclease ABC activity
BC350_RS00950	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BC350_RS00960	COG0736	holo-[acyl-carrier-protein] synthase activity
BC350_RS00965	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BC350_RS00975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BC350_RS00980	COG0571	ribonuclease III activity
BC350_RS00990	COG0681	Belongs to the peptidase S26 family
BC350_RS00995	COG0481	GTPase activity
BC350_RS01005	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC350_RS01030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC350_RS01035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC350_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS01050	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BC350_RS01055	COG0416	fatty acid biosynthetic process
BC350_RS01060	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BC350_RS01065	COG1399	metal-binding, possibly nucleic acid-binding protein
BC350_RS01070	COG0424	maF-like protein
BC350_RS01080	COG0616	signal peptide processing
BC350_RS01080	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BC350_RS01090	COG0546	phosphoglycolate phosphatase activity
BC350_RS01100	COG1530	ribonuclease E activity
BC350_RS01105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BC350_RS01110	COG0746	molybdenum cofactor guanylyltransferase activity
BC350_RS01125	COG1322	Protein conserved in bacteria
BC350_RS01130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC350_RS01145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
BC350_RS01155	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS01160	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BC350_RS01170	COG3385	transposase activity
BC350_RS01185	COG0443	Heat shock 70 kDa protein
BC350_RS01190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BC350_RS01200	COG0316	Belongs to the HesB IscA family
BC350_RS01205	COG0822	iron-sulfur transferase activity
BC350_RS01210	COG1104	cysteine desulfurase activity
BC350_RS01220	COG1879	ABC-type sugar transport system periplasmic component
BC350_RS01230	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC350_RS01235	COG1609	Transcriptional regulator
BC350_RS01240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC350_RS01250	COG0556	nucleotide-excision repair
BC350_RS01265	COG1309	transcriptional regulator
BC350_RS01270	COG2878	Part of a membrane complex involved in electron transport
BC350_RS01275	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BC350_RS01280	COG0778	Nitroreductase
BC350_RS01310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC350_RS01350	COG0326	Molecular chaperone. Has ATPase activity
BC350_RS01355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS01360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC350_RS01365	COG0697	spore germination
BC350_RS01375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS01380	COG0625	glutathione transferase activity
BC350_RS01395	COG1620	l-lactate permease
BC350_RS01415	COG0741	lytic transglycosylase activity
BC350_RS01425	COG0488	(ABC) transporter
BC350_RS01465	COG0513	Belongs to the DEAD box helicase family
BC350_RS01470	COG1262	PFAM Formylglycine-generating sulfatase enzyme
BC350_RS01480	COG0861	Integral membrane protein TerC family
BC350_RS01490	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BC350_RS01500	COG0312	modulator of DNA gyrase
BC350_RS01505	COG3028	Belongs to the UPF0307 family
BC350_RS01510	COG0521	Mo-molybdopterin cofactor biosynthetic process
BC350_RS01515	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BC350_RS01520	COG0501	Belongs to the peptidase M48B family
BC350_RS01525	COG1162	GTPase activity
BC350_RS01535	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BC350_RS01540	COG0494	nUDIX hydrolase
BC350_RS01545	COG0335	large ribosomal subunit rRNA binding
BC350_RS01550	COG0336	Belongs to the RNA methyltransferase TrmD family
BC350_RS01555	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BC350_RS01560	COG0228	four-way junction DNA binding
BC350_RS01595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS01600	COG1960	acyl-CoA dehydrogenase activity
BC350_RS01620	COG2011	ABC-type metal ion transport system permease component
BC350_RS01625	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BC350_RS01630	COG0123	including yeast histone deacetylase and acetoin utilization protein
BC350_RS01635	COG2951	lytic endotransglycosylase activity
BC350_RS01650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC350_RS01655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
BC350_RS01665	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
BC350_RS01675	COG0776	regulation of translation
BC350_RS01685	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BC350_RS01690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BC350_RS01695	COG0287	Prephenate dehydrogenase
BC350_RS01700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC350_RS01705	COG0077	Prephenate dehydratase
BC350_RS01705	COG1605	Chorismate mutase
BC350_RS01710	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BC350_RS01735	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BC350_RS01800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC350_RS01810	COG3210	domain, Protein
BC350_RS01895	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BC350_RS01935	COG4221	oxidoreductase activity
BC350_RS02070	COG3311	Transcriptional regulator
BC350_RS02085	COG0464	growth
BC350_RS02090	COG3039	Transposase
BC350_RS02215	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC350_RS02245	COG3385	transposase activity
BC350_RS02320	COG3039	Transposase
BC350_RS02350	COG4974	Belongs to the 'phage' integrase family
BC350_RS02360	COG4974	Belongs to the 'phage' integrase family
BC350_RS02385	COG3039	Transposase
BC350_RS02495	COG2916	Histone family protein nucleoid-structuring protein H-NS
BC350_RS02515	COG4974	Belongs to the 'phage' integrase family
BC350_RS02520	COG0582	viral genome integration into host DNA
BC350_RS02525	COG4974	Belongs to the 'phage' integrase family
BC350_RS02615	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BC350_RS02670	COG1309	transcriptional regulator
BC350_RS02680	COG0604	alcohol dehydrogenase
BC350_RS02720	COG2963	transposase activity
BC350_RS02735	COG0778	Nitroreductase
BC350_RS02770	COG1280	lysine exporter protein (LysE YggA)
BC350_RS02785	COG0425	Belongs to the sulfur carrier protein TusA family
BC350_RS02800	COG1942	4-Oxalocrotonate Tautomerase
BC350_RS02805	COG0235	Class ii aldolase
BC350_RS02810	COG0477	Major facilitator Superfamily
BC350_RS02825	COG0330	HflC and HflK could
BC350_RS02850	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BC350_RS02855	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC350_RS02880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC350_RS02910	COG4681	YaeQ
BC350_RS02925	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BC350_RS02935	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS02940	COG3118	belongs to the thioredoxin family
BC350_RS02950	COG2703	oxygen carrier activity
BC350_RS02955	COG3039	Transposase
BC350_RS02960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
BC350_RS02965	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
BC350_RS02970	COG2982	Protein involved in outer membrane biogenesis
BC350_RS02995	COG0259	pyridoxamine-phosphate oxidase activity
BC350_RS03000	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BC350_RS03010	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC350_RS03015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC350_RS03025	COG1522	sequence-specific DNA binding
BC350_RS03030	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BC350_RS03040	COG3483	tryptophan 2,3-dioxygenase activity
BC350_RS03050	COG1960	acyl-CoA dehydrogenase activity
BC350_RS03055	COG2252	PERMEase
BC350_RS03060	COG0450	alkyl hydroperoxide reductase
BC350_RS03065	COG4575	ribosome binding
BC350_RS03085	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC350_RS03090	COG0390	transport system, permease component
BC350_RS03100	COG2175	clavaminate synthase activity
BC350_RS03115	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BC350_RS03120	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BC350_RS03125	COG0745	RESPONSE REGULATOR receiver
BC350_RS03140	COG2391	methyltransferase activity
BC350_RS03145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BC350_RS03160	COG0823	Involved in the tonB-independent uptake of proteins
BC350_RS03180	COG0824	Thioesterase
BC350_RS03185	COG4221	oxidoreductase activity
BC350_RS03190	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BC350_RS03195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BC350_RS03275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BC350_RS03280	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC350_RS03285	COG0436	Aminotransferase
BC350_RS03295	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BC350_RS03325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BC350_RS03330	COG1902	pentaerythritol trinitrate reductase activity
BC350_RS03335	COG1968	undecaprenyl-diphosphatase activity
BC350_RS03360	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BC350_RS03365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC350_RS03365	COG0425	Belongs to the sulfur carrier protein TusA family
BC350_RS03385	COG0859	PFAM glycosyl transferase family 9
BC350_RS03400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC350_RS03440	COG1088	dTDP-glucose 4,6-dehydratase activity
BC350_RS03445	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BC350_RS03460	COG0540	Belongs to the ATCase OTCase family
BC350_RS03465	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BC350_RS03470	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BC350_RS03475	COG1678	Uncharacterized ACR, COG1678
BC350_RS03480	COG1187	pseudouridine synthase activity
BC350_RS03490	COG2198	Histidine kinase
BC350_RS03490	COG0784	Response regulator, receiver
BC350_RS03490	COG0643	Histidine kinase
BC350_RS03495	COG0840	transmembrane signaling receptor activity
BC350_RS03515	COG1773	rubredoxin
BC350_RS03520	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC350_RS03525	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC350_RS03535	COG1704	LemA family
BC350_RS03580	COG4964	Belongs to the GSP D family
BC350_RS03660	COG4269	membrane
BC350_RS03665	COG0459	protein refolding
BC350_RS03670	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BC350_RS03675	COG0443	Heat shock 70 kDa protein
BC350_RS03685	COG1309	transcriptional regulator
BC350_RS03695	COG0583	DNA-binding transcription factor activity
BC350_RS03705	COG1064	alcohol dehydrogenase
BC350_RS03720	COG3039	Transposase
BC350_RS03730	COG4654	Cytochrome c, class I
BC350_RS03750	COG2207	Transcriptional regulator
BC350_RS03755	COG1063	alcohol dehydrogenase
BC350_RS03770	COG0513	Belongs to the DEAD box helicase family
BC350_RS03785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BC350_RS03790	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
BC350_RS03795	COG2974	May be involved in recombination
BC350_RS03815	COG0697	spore germination
BC350_RS03855	COG0840	transmembrane signaling receptor activity
BC350_RS03860	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
BC350_RS03880	COG2995	paraquat-inducible protein a
BC350_RS03885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BC350_RS03885	COG3008	intermembrane lipid transfer
BC350_RS03895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS03900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS03965	COG0738	Major facilitator superfamily
BC350_RS03970	COG2027	D-alanyl-D-alanine carboxypeptidase
BC350_RS03975	COG1763	Mo-molybdopterin cofactor biosynthetic process
BC350_RS03985	COG0546	phosphoglycolate phosphatase activity
BC350_RS03995	COG0009	L-threonylcarbamoyladenylate synthase
BC350_RS04000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BC350_RS04005	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BC350_RS04010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BC350_RS04020	COG0469	pyruvate kinase activity
BC350_RS04025	COG0126	phosphoglycerate kinase activity
BC350_RS04055	COG0859	PFAM glycosyl transferase family 9
BC350_RS04065	COG0429	hydrolase of the alpha beta-hydrolase fold
BC350_RS04075	COG4783	chaperone-mediated protein folding
BC350_RS04080	COG0315	cyclic pyranopterin monophosphate synthase activity
BC350_RS04090	COG4969	Belongs to the N-Me-Phe pilin family
BC350_RS04100	COG0861	Integral membrane protein TerC family
BC350_RS04110	COG0045	succinate-CoA ligase (ADP-forming) activity
BC350_RS04120	COG2137	regulation of response to DNA damage stimulus
BC350_RS04125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BC350_RS04145	COG0477	Major facilitator Superfamily
BC350_RS04170	COG0745	RESPONSE REGULATOR receiver
BC350_RS04190	COG0513	Belongs to the DEAD box helicase family
BC350_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS04250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC350_RS04255	COG1702	phosphate starvation-inducible protein PhoH
BC350_RS04260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BC350_RS04265	COG4535	Mg2 and Co2 transporter CorC
BC350_RS04270	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BC350_RS04275	COG0752	glycyl-tRNA synthetase alpha subunit
BC350_RS04285	COG0751	glycine-tRNA ligase activity
BC350_RS04290	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BC350_RS04295	COG0204	Acyl-transferase
BC350_RS04305	COG0346	lactoylglutathione lyase activity
BC350_RS04310	COG0697	spore germination
BC350_RS04315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BC350_RS04320	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BC350_RS04325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC350_RS04330	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BC350_RS04350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BC350_RS04360	COG0006	proline dipeptidase activity
BC350_RS04365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BC350_RS04375	COG4680	protein conserved in bacteria
BC350_RS04390	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
BC350_RS04395	COG0138	bifunctional purine biosynthesis protein purh
BC350_RS04400	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BC350_RS04410	COG0632	four-way junction helicase activity
BC350_RS04415	COG2255	four-way junction helicase activity
BC350_RS04430	COG1490	D-aminoacyl-tRNA deacylase activity
BC350_RS04435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BC350_RS04440	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BC350_RS04445	COG0316	Belongs to the HesB IscA family
BC350_RS04460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BC350_RS04465	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BC350_RS04485	COG0418	dihydroorotase activity
BC350_RS04495	COG0473	3-isopropylmalate dehydrogenase activity
BC350_RS04500	COG0121	glutamine amidotransferase
BC350_RS04505	COG1126	abc transporter atp-binding protein
BC350_RS04510	COG0765	amino acid transport
BC350_RS04515	COG0765	amino acid transport
BC350_RS04525	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BC350_RS04545	COG1024	Enoyl-CoA hydratase
BC350_RS04550	COG0183	Belongs to the thiolase family
BC350_RS04555	COG1024	Enoyl-CoA hydratase
BC350_RS04555	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC350_RS04560	COG1960	acyl-CoA dehydrogenase activity
BC350_RS04575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC350_RS04580	COG3568	Endonuclease Exonuclease Phosphatase
BC350_RS04585	COG0494	nUDIX hydrolase
BC350_RS04595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BC350_RS04620	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BC350_RS04635	COG2226	methyltransferase
BC350_RS04645	COG4178	(ABC) transporter
BC350_RS04660	COG1238	metal cluster binding
BC350_RS04680	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BC350_RS04685	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC350_RS04685	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BC350_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS04720	COG3265	gluconokinase activity
BC350_RS04735	COG2391	methyltransferase activity
BC350_RS04765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC350_RS04790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC350_RS04945	COG4974	Belongs to the 'phage' integrase family
BC350_RS04955	COG0629	single-stranded DNA binding
BC350_RS04960	COG2814	Major facilitator Superfamily
BC350_RS04975	COG1280	lysine exporter protein (LysE YggA)
BC350_RS04980	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BC350_RS04985	COG0693	protein deglycase activity
BC350_RS05010	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
BC350_RS05025	COG1137	ATPase activity
BC350_RS05030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BC350_RS05035	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BC350_RS05045	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BC350_RS05050	COG3039	Transposase
BC350_RS05060	COG1660	Displays ATPase and GTPase activities
BC350_RS05070	COG1194	a g-specific adenine glycosylase
BC350_RS05080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BC350_RS05090	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
BC350_RS05095	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BC350_RS05105	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC350_RS05110	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BC350_RS05115	COG0193	aminoacyl-tRNA hydrolase activity
BC350_RS05125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BC350_RS05130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BC350_RS05135	COG0742	ribosomal rna small subunit methyltransferase
BC350_RS05140	COG0612	Peptidase, M16
BC350_RS05145	COG0612	Peptidase, M16
BC350_RS05160	COG0625	glutathione transferase activity
BC350_RS05170	COG3707	response regulator
BC350_RS05180	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC350_RS05185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC350_RS05190	COG1116	anion transmembrane transporter activity
BC350_RS05195	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC350_RS05200	COG1741	Belongs to the pirin family
BC350_RS05210	COG5001	Diguanylate cyclase
BC350_RS05210	COG3300	MHYT domain
BC350_RS05215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BC350_RS05220	COG1999	signal sequence binding
BC350_RS05225	COG0109	protoheme IX farnesyltransferase activity
BC350_RS05230	COG1612	heme a metabolic process
BC350_RS05260	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BC350_RS05265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC350_RS05280	COG2226	methyltransferase
BC350_RS05285	COG1040	competence protein
BC350_RS05295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BC350_RS05300	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
BC350_RS05305	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BC350_RS05310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BC350_RS05315	COG0588	phosphoglycerate mutase activity
BC350_RS05320	COG0793	Belongs to the peptidase S41A family
BC350_RS05340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC350_RS05345	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC350_RS05355	COG0189	ligase activity
BC350_RS05365	COG0004	ammonium transporteR
BC350_RS05390	COG0606	chelatase, subunit chli
BC350_RS05410	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BC350_RS05420	COG2204	response regulator
BC350_RS05430	COG1301	dicarboxylic acid transport
BC350_RS05435	COG3411	Ferredoxin
BC350_RS05445	COG1686	Belongs to the peptidase S11 family
BC350_RS05450	COG2921	Belongs to the UPF0250 family
BC350_RS05455	COG0583	DNA-binding transcription factor activity
BC350_RS05465	COG0321	lipoyl(octanoyl) transferase activity
BC350_RS05470	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BC350_RS05485	COG3511	phospholipase C
BC350_RS05515	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BC350_RS05520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BC350_RS05520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BC350_RS05525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BC350_RS05535	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BC350_RS05560	COG1024	Enoyl-CoA hydratase
BC350_RS05590	COG2267	carboxylic ester hydrolase activity
BC350_RS05610	COG0646	methionine synthase
BC350_RS05610	COG1410	methionine synthase
BC350_RS05620	COG2197	response regulator
BC350_RS05645	COG0018	arginyl-trna synthetase
BC350_RS05655	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BC350_RS05660	COG4221	oxidoreductase activity
BC350_RS05670	COG2329	Antibiotic biosynthesis monooxygenase
BC350_RS05680	COG0789	Transcriptional regulator
BC350_RS05685	COG1960	acyl-CoA dehydrogenase activity
BC350_RS05690	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
BC350_RS05695	COG0288	reversible hydration of carbon dioxide
BC350_RS05705	COG0183	Belongs to the thiolase family
BC350_RS05710	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS05715	COG1960	acyl-CoA dehydrogenase activity
BC350_RS05730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC350_RS05735	COG3012	SEC-C Motif Domain Protein
BC350_RS05740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BC350_RS05750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BC350_RS05755	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BC350_RS05760	COG4770	biotin carboxylase activity
BC350_RS05775	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC350_RS05795	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC350_RS05805	COG0596	Alpha beta hydrolase
BC350_RS05860	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC350_RS05865	COG0583	DNA-binding transcription factor activity
BC350_RS05895	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC350_RS05895	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BC350_RS05895	COG1703	isobutyryl-CoA mutase activity
BC350_RS05935	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS05950	COG0430	RNA-3'-phosphate cyclase activity
BC350_RS05960	COG1690	Belongs to the RtcB family
BC350_RS05970	COG4650	regulator
BC350_RS05985	COG1254	Belongs to the acylphosphatase family
BC350_RS06000	COG0667	Aldo Keto reductase
BC350_RS06005	COG2814	Major facilitator Superfamily
BC350_RS06010	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS06015	COG0583	DNA-binding transcription factor activity
BC350_RS06020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC350_RS06020	COG0519	Catalyzes the synthesis of GMP from XMP
BC350_RS06035	COG1733	regulation of RNA biosynthetic process
BC350_RS06070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BC350_RS06080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BC350_RS06085	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
BC350_RS06090	COG0071	Belongs to the small heat shock protein (HSP20) family
BC350_RS06105	COG3038	cytochrome b561
BC350_RS06125	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BC350_RS06130	COG1063	alcohol dehydrogenase
BC350_RS06140	COG2197	response regulator
BC350_RS06145	COG3851	Histidine kinase
BC350_RS06150	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC350_RS06180	COG0589	response to stress
BC350_RS06185	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
BC350_RS06205	COG0589	response to stress
BC350_RS06230	COG3039	Transposase
BC350_RS06270	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BC350_RS06275	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BC350_RS06285	COG0037	tRNA processing
BC350_RS06290	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC350_RS06295	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BC350_RS06295	COG0546	phosphoglycolate phosphatase activity
BC350_RS06320	COG0493	'glutamate synthase
BC350_RS06335	COG0842	Transport permease protein
BC350_RS06340	COG1131	(ABC) transporter
BC350_RS06355	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS06360	COG0583	DNA-binding transcription factor activity
BC350_RS06365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC350_RS06380	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS06390	COG2223	nitrite transmembrane transporter activity
BC350_RS06405	COG0697	spore germination
BC350_RS06430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BC350_RS06450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
BC350_RS06455	COG4682	membrane
BC350_RS06460	COG0708	Exodeoxyribonuclease III
BC350_RS06465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BC350_RS06470	COG2326	polyphosphate kinase activity
BC350_RS06475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BC350_RS06480	COG1560	Kdo2-lipid A biosynthetic process
BC350_RS06490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BC350_RS06510	COG0517	IMP dehydrogenase activity
BC350_RS06520	COG1522	sequence-specific DNA binding
BC350_RS06555	COG1960	acyl-CoA dehydrogenase activity
BC350_RS06590	COG2070	2-Nitropropane dioxygenase
BC350_RS06595	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BC350_RS06610	COG2022	thiamine diphosphate biosynthetic process
BC350_RS06620	COG2764	glyoxalase bleomycin resistance protein dioxygenase
BC350_RS06670	COG0351	phosphomethylpyrimidine kinase
BC350_RS06680	COG1785	Belongs to the alkaline phosphatase family
BC350_RS06685	COG1785	Belongs to the alkaline phosphatase family
BC350_RS06700	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BC350_RS06705	COG1950	PFAM Membrane protein of
BC350_RS06710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BC350_RS06720	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BC350_RS06740	COG0617	tRNA 3'-terminal CCA addition
BC350_RS06750	COG3246	L-lysine catabolic process to acetate
BC350_RS06755	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC350_RS06780	COG2204	response regulator
BC350_RS06785	COG5000	phosphorelay sensor kinase activity
BC350_RS06800	COG0501	Belongs to the peptidase M48B family
BC350_RS06810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC350_RS06820	COG0242	peptide deformylase activity
BC350_RS06825	COG1652	LysM domain
BC350_RS06830	COG0758	DNA mediated transformation
BC350_RS06845	COG0583	DNA-binding transcription factor activity
BC350_RS06850	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS06855	COG0772	Belongs to the SEDS family
BC350_RS06860	COG0768	penicillin binding
BC350_RS06870	COG1792	Involved in formation and maintenance of cell shape
BC350_RS06875	COG1077	Cell shape determining protein MreB Mrl
BC350_RS06880	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC350_RS06885	COG0154	amidase activity
BC350_RS06900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BC350_RS06910	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BC350_RS06915	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BC350_RS06935	COG0523	cobalamin synthesis protein
BC350_RS06950	COG0747	negative chemotaxis
BC350_RS06955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BC350_RS06960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BC350_RS06970	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BC350_RS07000	COG1595	DNA-templated transcription, initiation
BC350_RS07005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC350_RS07030	COG3385	transposase activity
BC350_RS07040	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BC350_RS07050	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC350_RS07060	COG3385	transposase activity
BC350_RS07075	COG2879	small protein
BC350_RS07080	COG1966	Carbon starvation protein
BC350_RS07095	COG3622	Belongs to the hyi family
BC350_RS07110	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
BC350_RS07120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BC350_RS07125	COG3384	dioxygenase
BC350_RS07140	COG1309	transcriptional regulator
BC350_RS07145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS07160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BC350_RS07180	COG0706	membrane insertase activity
BC350_RS07185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BC350_RS07190	COG0594	ribonuclease P activity
BC350_RS07195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BC350_RS07200	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC350_RS07205	COG0592	DNA-directed DNA polymerase activity
BC350_RS07230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BC350_RS07260	COG2963	transposase activity
BC350_RS07280	COG3781	membrane
BC350_RS07305	COG0765	amino acid transport
BC350_RS07310	COG1126	abc transporter atp-binding protein
BC350_RS07315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS07335	COG0642	Histidine kinase
BC350_RS07350	COG2814	Major facilitator Superfamily
BC350_RS07365	COG1959	2 iron, 2 sulfur cluster binding
BC350_RS07390	COG0745	RESPONSE REGULATOR receiver
BC350_RS07395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC350_RS07415	COG4251	negative regulation of phosphorylation
BC350_RS07415	COG3706	GGDEF domain
BC350_RS07415	COG2203	Gaf domain
BC350_RS07415	COG5001	Diguanylate cyclase
BC350_RS07425	COG2205	protein histidine kinase activity
BC350_RS07430	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BC350_RS07435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
BC350_RS07440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BC350_RS07475	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC350_RS07485	COG1116	anion transmembrane transporter activity
BC350_RS07495	COG1254	Belongs to the acylphosphatase family
BC350_RS07505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BC350_RS07510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC350_RS07515	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BC350_RS07520	COG2894	cell division
BC350_RS07525	COG0850	regulation of cytokinetic process
BC350_RS07530	COG0737	Belongs to the 5'-nucleotidase family
BC350_RS07540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC350_RS07565	COG2154	pterin-4-alpha-carbinolamine dehydratase
BC350_RS07570	COG3186	Phenylalanine-4-hydroxylase
BC350_RS07585	COG2423	ornithine cyclodeaminase activity
BC350_RS07595	COG3047	cAMP biosynthetic process
BC350_RS07605	COG2217	Heavy metal translocating P-type atpase
BC350_RS07610	COG0789	Transcriptional regulator
BC350_RS07615	COG2267	carboxylic ester hydrolase activity
BC350_RS07680	COG3530	Putative quorum-sensing-regulated virulence factor
BC350_RS07685	COG0583	DNA-binding transcription factor activity
BC350_RS07705	COG0445	tRNA wobble uridine modification
BC350_RS07710	COG0357	Ribosomal RNA small subunit methyltransferase G
BC350_RS07715	COG1192	Involved in chromosome partitioning
BC350_RS07720	COG1475	DNA binding
BC350_RS07730	COG0356	it plays a direct role in the translocation of protons across the membrane
BC350_RS07740	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BC350_RS07745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BC350_RS07750	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BC350_RS07755	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BC350_RS07760	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BC350_RS07765	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC350_RS07780	COG1832	CoA-binding protein
BC350_RS07800	COG0625	glutathione transferase activity
BC350_RS07830	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BC350_RS07835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BC350_RS07840	COG0506	proline dehydrogenase activity
BC350_RS07840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BC350_RS07840	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
BC350_RS07845	COG0683	leucine binding
BC350_RS07855	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BC350_RS07860	COG1297	OPT oligopeptide transporter protein
BC350_RS07865	COG1760	l-serine dehydratase
BC350_RS07870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC350_RS07870	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BC350_RS07875	COG0509	glycine decarboxylation via glycine cleavage system
BC350_RS07880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BC350_RS07900	COG0210	DNA helicase
BC350_RS07910	COG2197	response regulator
BC350_RS07915	COG3916	Acyl-homoserine-lactone synthase
BC350_RS07925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC350_RS07940	COG3622	Belongs to the hyi family
BC350_RS07945	COG3960	tartronate-semialdehyde synthase activity
BC350_RS07950	COG0583	DNA-binding transcription factor activity
BC350_RS07965	COG1739	Uncharacterized protein family UPF0029
BC350_RS07975	COG1301	dicarboxylic acid transport
BC350_RS07980	COG4266	Belongs to the allantoicase family
BC350_RS07990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC350_RS08015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC350_RS08030	COG0792	nuclease activity
BC350_RS08045	COG0446	pyridine nucleotide-disulphide oxidoreductase
BC350_RS08055	COG4654	Cytochrome c, class I
BC350_RS08080	COG2010	Cytochrome c
BC350_RS08085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC350_RS08090	COG0737	Belongs to the 5'-nucleotidase family
BC350_RS08100	COG3039	Transposase
BC350_RS08165	COG1301	dicarboxylic acid transport
BC350_RS08170	COG0583	DNA-binding transcription factor activity
BC350_RS08180	COG2814	Major facilitator Superfamily
BC350_RS08185	COG1280	lysine exporter protein (LysE YggA)
BC350_RS08205	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BC350_RS08215	COG0402	S-adenosylhomocysteine deaminase activity
BC350_RS08235	COG3039	Transposase
BC350_RS08245	COG0529	Catalyzes the synthesis of activated sulfate
BC350_RS08260	COG0457	Tetratricopeptide repeat
BC350_RS08285	COG0493	'glutamate synthase
BC350_RS08300	COG3385	transposase activity
BC350_RS08305	COG1278	Cold shock
BC350_RS08370	COG4251	negative regulation of phosphorylation
BC350_RS08370	COG3706	GGDEF domain
BC350_RS08370	COG2203	Gaf domain
BC350_RS08370	COG5001	Diguanylate cyclase
BC350_RS08385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC350_RS08395	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS08405	COG0840	transmembrane signaling receptor activity
BC350_RS08430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC350_RS08440	COG3284	Transcriptional regulator
BC350_RS08450	COG4303	Ethanolamine ammonia lyase large subunit
BC350_RS08455	COG4302	ethanolamine ammonia-lyase activity
BC350_RS08460	COG2925	Exonuclease
BC350_RS08575	COG1522	sequence-specific DNA binding
BC350_RS08585	COG1404	Belongs to the peptidase S8 family
BC350_RS08610	COG0475	glutathione-regulated potassium exporter activity
BC350_RS08610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BC350_RS08635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS08645	COG0745	RESPONSE REGULATOR receiver
BC350_RS08700	COG4695	Portal protein
BC350_RS08840	COG0863	Belongs to the N(4) N(6)-methyltransferase family
BC350_RS08930	COG0582	viral genome integration into host DNA
BC350_RS08970	COG2197	response regulator
BC350_RS08975	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BC350_RS09010	COG2814	Major facilitator Superfamily
BC350_RS09015	COG0668	transmembrane transport
BC350_RS09030	COG0745	RESPONSE REGULATOR receiver
BC350_RS09035	COG2205	protein histidine kinase activity
BC350_RS09065	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BC350_RS09070	COG2336	PFAM SpoVT AbrB
BC350_RS09090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BC350_RS09105	COG0395	ABC-type sugar transport system, permease component
BC350_RS09115	COG3842	ATPase activity
BC350_RS09120	COG3842	ATPase activity
BC350_RS09130	COG1349	DNA-binding transcription factor activity
BC350_RS09180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC350_RS09200	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BC350_RS09205	COG0081	regulation of translation
BC350_RS09210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BC350_RS09215	COG0222	ribosome binding
BC350_RS09220	COG0085	RNA polymerase activity
BC350_RS09225	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BC350_RS09230	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
BC350_RS09235	COG3234	Protein of unknown function (DUF1175)
BC350_RS09240	COG2373	Large extracellular alpha-helical protein
BC350_RS09245	COG5445	Predicted secreted protein (DUF2300)
BC350_RS09250	COG4676	Protein conserved in bacteria
BC350_RS09265	COG0514	ATP-dependent DNA helicase (RecQ)
BC350_RS09270	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BC350_RS09275	COG0049	tRNA binding
BC350_RS09280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC350_RS09285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BC350_RS09290	COG0051	transcription antitermination factor activity, RNA binding
BC350_RS09295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BC350_RS09300	COG0088	Forms part of the polypeptide exit tunnel
BC350_RS09305	COG0089	rRNA binding
BC350_RS09310	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BC350_RS09315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BC350_RS09320	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BC350_RS09325	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BC350_RS09330	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BC350_RS09335	COG0255	Belongs to the universal ribosomal protein uL29 family
BC350_RS09340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BC350_RS09345	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BC350_RS09350	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BC350_RS09355	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BC350_RS09360	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BC350_RS09365	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BC350_RS09370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BC350_RS09375	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BC350_RS09380	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BC350_RS09385	COG1841	ribosomal large subunit assembly
BC350_RS09390	COG0200	Binds to the 23S rRNA
BC350_RS09395	COG0201	protein transport
BC350_RS09400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC350_RS09405	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BC350_RS09410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BC350_RS09415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BC350_RS09420	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BC350_RS09425	COG0202	RNA polymerase activity
BC350_RS09430	COG0203	ribosomal protein L17
BC350_RS09450	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BC350_RS09460	COG1333	cytochrome c biogenesis protein
BC350_RS09465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BC350_RS09485	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BC350_RS09490	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BC350_RS09505	COG1965	Belongs to the frataxin family
BC350_RS09540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BC350_RS09550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BC350_RS09555	COG3047	cAMP biosynthetic process
BC350_RS09565	COG0067	glutamate synthase
BC350_RS09565	COG0069	glutamate synthase activity
BC350_RS09565	COG0070	glutamate synthase
BC350_RS09580	COG1127	ABC transporter
BC350_RS09585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BC350_RS09590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BC350_RS09610	COG1131	(ABC) transporter
BC350_RS09615	COG0842	Transport permease protein
BC350_RS09625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BC350_RS09630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BC350_RS09635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BC350_RS09640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BC350_RS09645	COG0131	Imidazoleglycerol-phosphate dehydratase
BC350_RS09650	COG2095	MarC family integral membrane protein
BC350_RS09655	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BC350_RS09660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BC350_RS09665	COG0107	imidazoleglycerol-phosphate synthase activity
BC350_RS09670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BC350_RS09675	COG0140	phosphoribosyl-ATP diphosphatase activity
BC350_RS09685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BC350_RS09690	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BC350_RS09695	COG0805	protein transport
BC350_RS09700	COG3842	ATPase activity
BC350_RS09710	COG1840	ABC-type Fe3 transport system, periplasmic component
BC350_RS09715	COG0642	Histidine kinase
BC350_RS09730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS09735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC350_RS09740	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BC350_RS09745	COG1970	mechanosensitive ion channel activity
BC350_RS09750	COG0723	plastoquinol--plastocyanin reductase activity
BC350_RS09755	COG0723	plastoquinol--plastocyanin reductase activity
BC350_RS09760	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BC350_RS09765	COG2857	Cytochrome c1
BC350_RS09770	COG0625	glutathione transferase activity
BC350_RS09775	COG2969	positive regulation of protein catabolic process
BC350_RS09800	COG0405	Gamma-glutamyltransferase
BC350_RS09810	COG3712	iron ion homeostasis
BC350_RS09820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC350_RS09835	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BC350_RS09840	COG0488	(ABC) transporter
BC350_RS09860	COG2943	transferase activity, transferring hexosyl groups
BC350_RS09860	COG3416	Protein conserved in bacteria
BC350_RS09865	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BC350_RS09880	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BC350_RS09885	COG2890	protein-(glutamine-N5) methyltransferase activity
BC350_RS09895	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BC350_RS09900	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BC350_RS09910	COG0012	GTP binding
BC350_RS09940	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BC350_RS09950	COG0604	alcohol dehydrogenase
BC350_RS09960	COG1289	transmembrane transporter activity
BC350_RS09975	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BC350_RS09985	COG0134	indole-3-glycerol-phosphate synthase activity
BC350_RS09990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC350_RS10000	COG0512	Glutamine amidotransferase of anthranilate synthase
BC350_RS10010	COG0546	phosphoglycolate phosphatase activity
BC350_RS10015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BC350_RS10020	COG2967	ApaG domain
BC350_RS10040	COG2050	protein possibly involved in aromatic compounds catabolism
BC350_RS10050	COG1024	Enoyl-CoA hydratase
BC350_RS10080	COG1473	amidohydrolase
BC350_RS10085	COG0747	negative chemotaxis
BC350_RS10090	COG0601	transmembrane transport
BC350_RS10095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC350_RS10100	COG0444	Belongs to the ABC transporter superfamily
BC350_RS10105	COG4608	Belongs to the ABC transporter superfamily
BC350_RS10115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC350_RS10115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
BC350_RS10120	COG1105	Belongs to the carbohydrate kinase PfkB family
BC350_RS10125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BC350_RS10125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
BC350_RS10130	COG1609	Transcriptional regulator
BC350_RS10135	COG0243	molybdopterin cofactor binding
BC350_RS10145	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS10150	COG0477	Major facilitator Superfamily
BC350_RS10155	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS10160	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
BC350_RS10165	COG2001	Belongs to the MraZ family
BC350_RS10170	COG0275	rRNA processing
BC350_RS10185	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BC350_RS10190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BC350_RS10195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BC350_RS10200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BC350_RS10210	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BC350_RS10215	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC350_RS10220	COG1181	Belongs to the D-alanine--D-alanine ligase family
BC350_RS10225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BC350_RS10240	COG0678	peroxiredoxin activity
BC350_RS10245	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
BC350_RS10255	COG0739	heme binding
BC350_RS10260	COG0653	protein targeting
BC350_RS10265	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BC350_RS10275	COG0494	nUDIX hydrolase
BC350_RS10280	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BC350_RS10285	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
BC350_RS10290	COG0237	dephospho-CoA kinase activity
BC350_RS10300	COG1459	type II secretion system
BC350_RS10310	COG4536	flavin adenine dinucleotide binding
BC350_RS10320	COG0142	geranyltranstransferase activity
BC350_RS10325	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BC350_RS10330	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BC350_RS10335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BC350_RS10340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BC350_RS10350	COG0494	nUDIX hydrolase
BC350_RS10355	COG0442	prolyl-tRNA aminoacylation
BC350_RS10360	COG0741	lytic transglycosylase activity
BC350_RS10370	COG2095	MarC family integral membrane protein
BC350_RS10375	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BC350_RS10380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BC350_RS10405	COG3023	N-Acetylmuramoyl-L-alanine amidase
BC350_RS10430	COG1522	sequence-specific DNA binding
BC350_RS10440	COG0840	transmembrane signaling receptor activity
BC350_RS10485	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC350_RS10490	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BC350_RS10500	COG2264	protein methyltransferase activity
BC350_RS10510	COG0511	ligase activity, forming carbon-carbon bonds
BC350_RS10515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BC350_RS10520	COG3118	belongs to the thioredoxin family
BC350_RS10530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BC350_RS10535	COG3150	esterase
BC350_RS10545	COG0557	exoribonuclease II activity
BC350_RS10555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BC350_RS10560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BC350_RS10575	COG0284	orotidine-5'-phosphate decarboxylase activity
BC350_RS10585	COG1058	Belongs to the CinA family
BC350_RS10585	COG1546	Belongs to the CinA family
BC350_RS10590	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BC350_RS10600	COG0281	malic enzyme
BC350_RS10600	COG0280	phosphate acetyltransferase
BC350_RS10620	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BC350_RS10630	COG0583	DNA-binding transcription factor activity
BC350_RS10635	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS10650	COG1129	ABC transporter
BC350_RS10670	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS10675	COG0800	Aldolase
BC350_RS10680	COG4948	Mandelate Racemase Muconate Lactonizing
BC350_RS10685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BC350_RS10690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BC350_RS10695	COG0583	DNA-binding transcription factor activity
BC350_RS10700	COG0735	belongs to the Fur family
BC350_RS10705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BC350_RS10710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BC350_RS10715	COG0495	leucyl-tRNA aminoacylation
BC350_RS10725	COG1466	dna polymerase III delta subunit
BC350_RS10730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BC350_RS10735	COG1981	membrane
BC350_RS10745	COG2204	response regulator
BC350_RS10750	COG4191	Histidine kinase
BC350_RS10780	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BC350_RS10800	COG2814	Major facilitator Superfamily
BC350_RS10820	COG0482	sulfurtransferase activity
BC350_RS10825	COG0069	glutamate synthase activity
BC350_RS10830	COG0625	glutathione transferase activity
BC350_RS10840	COG3038	cytochrome b561
BC350_RS10845	COG2353	YceI-like domain
BC350_RS10850	COG2353	YceI-like domain
BC350_RS10855	COG3385	transposase activity
BC350_RS10860	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC350_RS10865	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BC350_RS10870	COG1862	Preprotein translocase
BC350_RS10875	COG0343	queuine tRNA-ribosyltransferase activity
BC350_RS10880	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BC350_RS10885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BC350_RS10925	COG1522	sequence-specific DNA binding
BC350_RS10930	COG1473	amidohydrolase
BC350_RS10935	COG1819	glycosyl
BC350_RS10940	COG3039	Transposase
BC350_RS10985	COG1278	Cold shock
BC350_RS11075	COG0783	Belongs to the Dps family
BC350_RS11080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BC350_RS11140	COG0386	Belongs to the glutathione peroxidase family
BC350_RS11160	COG1346	cytolysis
BC350_RS11165	COG1380	Effector of murein hydrolase LrgA
BC350_RS11170	COG0247	lactate metabolic process
BC350_RS11175	COG0277	FAD linked oxidase domain protein
BC350_RS11180	COG0277	FAD linked oxidase domain protein
BC350_RS11185	COG0583	DNA-binding transcription factor activity
BC350_RS11190	COG0277	FAD linked oxidase domain protein
BC350_RS11195	COG2096	Adenosyltransferase
BC350_RS11200	COG0668	transmembrane transport
BC350_RS11210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BC350_RS11215	COG0312	modulator of DNA gyrase
BC350_RS11220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BC350_RS11230	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BC350_RS11245	COG1404	Belongs to the peptidase S8 family
BC350_RS11255	COG0497	DNA recombination
BC350_RS11260	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BC350_RS11265	COG1420	regulation of RNA biosynthetic process
BC350_RS11275	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BC350_RS11280	COG2986	histidine ammonia-lyase
BC350_RS11285	COG0010	Belongs to the arginase family
BC350_RS11290	COG1228	amidohydrolase
BC350_RS11295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
BC350_RS11315	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BC350_RS11325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC350_RS11330	COG0443	Heat shock 70 kDa protein
BC350_RS11340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BC350_RS11340	COG0512	Glutamine amidotransferase of anthranilate synthase
BC350_RS11345	COG1122	ATPase activity
BC350_RS11350	COG4662	Binding-protein-dependent transport system inner membrane component
BC350_RS11355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BC350_RS11365	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BC350_RS11380	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BC350_RS11385	COG0628	permease
BC350_RS11390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BC350_RS11405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC350_RS11405	COG2169	Transcriptional regulator
BC350_RS11425	COG2169	Transcriptional regulator
BC350_RS11425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BC350_RS11430	COG0456	acetyltransferase
BC350_RS11435	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BC350_RS11440	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BC350_RS11445	COG3008	intermembrane lipid transfer
BC350_RS11460	COG0586	Pfam SNARE associated Golgi protein
BC350_RS11470	COG0728	peptidoglycan biosynthetic process
BC350_RS11475	COG0268	Binds directly to 16S ribosomal RNA
BC350_RS11485	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BC350_RS11495	COG0137	argininosuccinate synthase activity
BC350_RS11500	COG3123	guanosine phosphorylase activity
BC350_RS11510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BC350_RS11515	COG1666	GTP binding
BC350_RS11525	COG2366	antibiotic biosynthetic process
BC350_RS11530	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BC350_RS11540	COG4974	Belongs to the 'phage' integrase family
BC350_RS11555	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BC350_RS11560	COG0802	atpase or kinase
BC350_RS11565	COG0860	N-Acetylmuramoyl-L-alanine amidase
BC350_RS11575	COG0583	DNA-binding transcription factor activity
BC350_RS11595	COG0563	adenylate kinase activity
BC350_RS11600	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BC350_RS11605	COG2835	tetraacyldisaccharide 4'-kinase activity
BC350_RS11610	COG1663	tetraacyldisaccharide 4'-kinase activity
BC350_RS11620	COG0811	peptide transport
BC350_RS11625	COG1570	exodeoxyribonuclease VII activity
BC350_RS11630	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BC350_RS11670	COG2610	gluconate transmembrane transporter activity
BC350_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS11745	COG2321	neutral zinc metallopeptidase
BC350_RS11760	COG2259	Doxx family
BC350_RS11770	COG0583	DNA-binding transcription factor activity
BC350_RS11775	COG0583	DNA-binding transcription factor activity
BC350_RS11795	COG1858	cytochrome C peroxidase
BC350_RS11830	COG1278	Cold shock
BC350_RS11835	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BC350_RS11840	COG0542	response to heat
BC350_RS11845	COG0756	dUTP diphosphatase activity
BC350_RS11850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC350_RS11855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BC350_RS11865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BC350_RS11870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BC350_RS11875	COG0196	riboflavin kinase activity
BC350_RS11880	COG5002	protein histidine kinase activity
BC350_RS11880	COG0784	Response regulator, receiver
BC350_RS11885	COG2197	response regulator
BC350_RS11890	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BC350_RS11895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BC350_RS11895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BC350_RS11905	COG1511	domain protein
BC350_RS11905	COG3264	Mechanosensitive ion channel
BC350_RS11915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BC350_RS11925	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BC350_RS11930	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BC350_RS11935	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BC350_RS11940	COG2003	Belongs to the UPF0758 family
BC350_RS11945	COG1047	Peptidyl-prolyl cis-trans
BC350_RS11950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BC350_RS11985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BC350_RS12035	COG0583	DNA-binding transcription factor activity
BC350_RS12045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC350_RS12055	COG0175	sulfate reduction
BC350_RS12065	COG2895	sulfate adenylyltransferase (ATP) activity
BC350_RS12095	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BC350_RS12110	COG0129	dihydroxy-acid dehydratase activity
BC350_RS12115	COG0583	DNA-binding transcription factor activity
BC350_RS12120	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BC350_RS12150	COG4206	TonB-dependent receptor
BC350_RS12160	COG1120	ATPase activity
BC350_RS12165	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BC350_RS12180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BC350_RS12190	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BC350_RS12200	COG1492	cobalamin metabolic process
BC350_RS12215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BC350_RS12220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BC350_RS12235	COG2911	Protein conserved in bacteria
BC350_RS12245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC350_RS12245	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC350_RS12250	COG3047	cAMP biosynthetic process
BC350_RS12250	COG2885	chlorophyll binding
BC350_RS12255	COG0489	protein tyrosine kinase activity
BC350_RS12290	COG0437	4 iron, 4 sulfur cluster binding
BC350_RS12310	COG2032	superoxide dismutase activity
BC350_RS12320	COG0717	Belongs to the dCTP deaminase family
BC350_RS12335	COG0165	Argininosuccinate lyase
BC350_RS12360	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
BC350_RS12365	COG0181	hydroxymethylbilane synthase activity
BC350_RS12390	COG2271	Major facilitator Superfamily
BC350_RS12405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BC350_RS12445	COG0492	ferredoxin-NADP+ reductase activity
BC350_RS12450	COG1674	ftsk spoiiie
BC350_RS12455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BC350_RS12465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC350_RS12470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC350_RS12610	COG0697	spore germination
BC350_RS12615	COG0583	DNA-binding transcription factor activity
BC350_RS12620	COG0582	viral genome integration into host DNA
BC350_RS12625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BC350_RS12630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BC350_RS12640	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BC350_RS12720	COG0582	viral genome integration into host DNA
BC350_RS12740	COG0514	ATP-dependent DNA helicase (RecQ)
BC350_RS12800	COG5377	YqaJ viral recombinase family
BC350_RS12845	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BC350_RS12870	COG1846	Transcriptional regulator
BC350_RS12880	COG2814	Major facilitator Superfamily
BC350_RS12890	COG4221	oxidoreductase activity
BC350_RS12905	COG1522	sequence-specific DNA binding
BC350_RS12915	COG2814	Major facilitator Superfamily
BC350_RS12935	COG2197	response regulator
BC350_RS12990	COG2165	general secretion pathway protein
BC350_RS13060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC350_RS13110	COG1253	flavin adenine dinucleotide binding
BC350_RS13165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS13185	COG0765	amino acid transport
BC350_RS13190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC350_RS13200	COG1414	Transcriptional regulator
BC350_RS13210	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BC350_RS13215	COG0183	Belongs to the thiolase family
BC350_RS13225	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BC350_RS13230	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC350_RS13245	COG0411	ABC transporter
BC350_RS13255	COG0683	leucine binding
BC350_RS13270	COG2342	PFAM TM1410 hypothetical-related protein
BC350_RS13280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BC350_RS13295	COG0525	valine-tRNA ligase activity
BC350_RS13300	COG0210	DNA helicase
BC350_RS13310	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BC350_RS13320	COG1611	Belongs to the LOG family
BC350_RS13325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC350_RS13325	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BC350_RS13330	COG1252	NADH dehydrogenase
BC350_RS13335	COG0412	Dienelactone hydrolase
BC350_RS13345	COG3385	transposase activity
BC350_RS13365	COG1722	exodeoxyribonuclease VII activity
BC350_RS13370	COG0142	geranyltranstransferase activity
BC350_RS13375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BC350_RS13380	COG1469	GTP cyclohydrolase I activity
BC350_RS13385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BC350_RS13390	COG2081	HI0933 family
BC350_RS13395	COG1610	YqeY-like protein
BC350_RS13415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC350_RS13425	COG0426	domain, Protein
BC350_RS13425	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BC350_RS13430	COG0513	Belongs to the DEAD box helicase family
BC350_RS13435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BC350_RS13440	COG0583	DNA-binding transcription factor activity
BC350_RS13445	COG1741	Belongs to the pirin family
BC350_RS13455	COG1054	Belongs to the UPF0176 family
BC350_RS13485	COG1132	(ABC) transporter
BC350_RS13505	COG1530	ribonuclease E activity
BC350_RS13510	COG0424	maF-like protein
BC350_RS13515	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BC350_RS13520	COG0799	negative regulation of ribosome biogenesis
BC350_RS13530	COG0408	coproporphyrinogen oxidase activity
BC350_RS13535	COG0151	Belongs to the GarS family
BC350_RS13540	COG0217	transcriptional regulatory protein
BC350_RS13545	COG0433	COG0433 Predicted ATPase
BC350_RS13550	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BC350_RS13555	COG0697	spore germination
BC350_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS13565	COG1803	Methylglyoxal synthase
BC350_RS13615	COG4603	Belongs to the binding-protein-dependent transport system permease family
BC350_RS13620	COG3845	ABC transporter
BC350_RS13625	COG2814	Major facilitator Superfamily
BC350_RS13630	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BC350_RS13635	COG1984	allophanate hydrolase subunit 2
BC350_RS13640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BC350_RS13655	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BC350_RS13660	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC350_RS13675	COG1234	tRNA 3'-trailer cleavage
BC350_RS13685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BC350_RS13690	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BC350_RS13695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
BC350_RS13705	COG3064	Membrane
BC350_RS13705	COG4991	sh3 domain protein
BC350_RS13705	COG0515	serine threonine protein kinase
BC350_RS13710	COG1561	YicC-like family, N-terminal region
BC350_RS13715	COG0194	GDP metabolic process
BC350_RS13720	COG1758	RNA polymerase activity
BC350_RS13725	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC350_RS13755	COG1652	LysM domain
BC350_RS13765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC350_RS13790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BC350_RS13795	COG3842	ATPase activity
BC350_RS13805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS13830	COG0246	Mannitol dehydrogenase
BC350_RS13835	COG1070	Carbohydrate kinase
BC350_RS13840	COG2390	Transcriptional regulator
BC350_RS13850	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BC350_RS13855	COG0308	aminopeptidase N
BC350_RS13865	COG0281	malic enzyme
BC350_RS13865	COG0280	phosphate acetyltransferase
BC350_RS13875	COG3648	Uricase
BC350_RS13875	COG3195	allantoin biosynthetic process
BC350_RS13890	COG2233	PERMEase
BC350_RS13900	COG2351	hydroxyisourate hydrolase activity
BC350_RS13915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS13920	COG2271	Major facilitator Superfamily
BC350_RS13925	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC350_RS13930	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS13940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS13950	COG1126	abc transporter atp-binding protein
BC350_RS13955	COG0765	amino acid transport
BC350_RS13960	COG0765	amino acid transport
BC350_RS13970	COG2186	Transcriptional regulator
BC350_RS13985	COG2119	membrane
BC350_RS13990	COG0402	S-adenosylhomocysteine deaminase activity
BC350_RS13995	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BC350_RS14005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BC350_RS14055	COG1309	transcriptional regulator
BC350_RS14065	COG0438	transferase activity, transferring glycosyl groups
BC350_RS14100	COG0028	Belongs to the TPP enzyme family
BC350_RS14110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BC350_RS14115	COG0688	phosphatidylethanolamine metabolic process
BC350_RS14120	COG1183	phosphatidylcholine synthase activity
BC350_RS14125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC350_RS14135	COG0683	leucine binding
BC350_RS14140	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BC350_RS14145	COG1185	polyribonucleotide nucleotidyltransferase activity
BC350_RS14160	COG0149	triose-phosphate isomerase activity
BC350_RS14165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BC350_RS14175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC350_RS14180	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC350_RS14185	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC350_RS14190	COG0649	NAD binding
BC350_RS14205	COG1034	ATP synthesis coupled electron transport
BC350_RS14210	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BC350_RS14215	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BC350_RS14225	COG0713	ATP synthesis coupled electron transport
BC350_RS14240	COG1007	ATP synthesis coupled electron transport
BC350_RS14265	COG1960	acyl-CoA dehydrogenase activity
BC350_RS14270	COG2030	dehydratase
BC350_RS14270	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS14305	COG0829	nickel cation binding
BC350_RS14310	COG0831	urea catabolic process
BC350_RS14320	COG0832	Belongs to the urease beta subunit family
BC350_RS14325	COG0804	urea catabolic process
BC350_RS14330	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BC350_RS14335	COG0830	nickel cation binding
BC350_RS14340	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
BC350_RS14365	COG0625	glutathione transferase activity
BC350_RS14370	COG1960	acyl-CoA dehydrogenase activity
BC350_RS14400	COG1024	Enoyl-CoA hydratase
BC350_RS14405	COG1250	3-hydroxyacyl-CoA dehydrogenase
BC350_RS14410	COG0625	glutathione transferase activity
BC350_RS14415	COG0436	Aminotransferase
BC350_RS14425	COG3022	response to hydroperoxide
BC350_RS14430	COG2866	Carboxypeptidase
BC350_RS14440	COG0747	negative chemotaxis
BC350_RS14455	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BC350_RS14480	COG0039	L-malate dehydrogenase activity
BC350_RS14485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS14495	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
BC350_RS14500	COG1053	succinate dehydrogenase
BC350_RS14505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BC350_RS14510	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BC350_RS14515	COG0372	Belongs to the citrate synthase family
BC350_RS14520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
BC350_RS14525	COG0066	3-isopropylmalate dehydratase activity
BC350_RS14530	COG0473	3-isopropylmalate dehydrogenase activity
BC350_RS14545	COG0101	tRNA pseudouridine synthase activity
BC350_RS14550	COG0135	phosphoribosylanthranilate isomerase activity
BC350_RS14555	COG0133	tryptophan synthase activity
BC350_RS14565	COG0159	tryptophan synthase activity
BC350_RS14570	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BC350_RS14575	COG0285	dihydrofolate synthase activity
BC350_RS14595	COG0842	Transport permease protein
BC350_RS14600	COG1131	(ABC) transporter
BC350_RS14630	COG3193	protein, possibly involved in utilization of glycolate and propanediol
BC350_RS14675	COG1301	dicarboxylic acid transport
BC350_RS14680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BC350_RS14695	COG0697	spore germination
BC350_RS14700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC350_RS14705	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BC350_RS14710	COG0840	transmembrane signaling receptor activity
BC350_RS14735	COG4695	Portal protein
BC350_RS14965	COG2197	response regulator
BC350_RS14970	COG0840	transmembrane signaling receptor activity
BC350_RS15010	COG0747	negative chemotaxis
BC350_RS15025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC350_RS15030	COG0601	transmembrane transport
BC350_RS15035	COG2072	flavoprotein involved in K transport
BC350_RS15080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BC350_RS15095	COG3039	Transposase
BC350_RS15125	COG0656	L-ascorbic acid biosynthetic process
BC350_RS15130	COG2304	oxidoreductase activity
BC350_RS15145	COG0589	response to stress
BC350_RS15180	COG0328	RNA-DNA hybrid ribonuclease activity
BC350_RS15185	COG2226	methyltransferase
BC350_RS15190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC350_RS15195	COG1388	LysM domain
BC350_RS15195	COG0741	lytic transglycosylase activity
BC350_RS15200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC350_RS15205	COG0505	Belongs to the CarA family
BC350_RS15215	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BC350_RS15220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BC350_RS15230	COG1534	Rna-binding protein
BC350_RS15235	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BC350_RS15240	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BC350_RS15245	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BC350_RS15250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BC350_RS15255	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BC350_RS15260	COG0573	inorganic phosphate transmembrane transporter activity
BC350_RS15265	COG0581	inorganic phosphate transmembrane transporter activity
BC350_RS15270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BC350_RS15280	COG0745	RESPONSE REGULATOR receiver
BC350_RS15290	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BC350_RS15295	COG0248	Ppx GppA phosphatase
BC350_RS15325	COG0730	response to heat
BC350_RS15335	COG0640	Transcriptional regulator
BC350_RS15345	COG3300	MHYT domain
BC350_RS15345	COG5001	Diguanylate cyclase
BC350_RS15355	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BC350_RS15380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BC350_RS15405	COG0277	FAD linked oxidase domain protein
BC350_RS15420	COG1295	ribonuclease BN
BC350_RS15445	COG0477	Major facilitator Superfamily
BC350_RS15450	COG0545	Peptidyl-prolyl cis-trans isomerase
BC350_RS15455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BC350_RS15465	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS15470	COG4566	intracellular signal transduction
BC350_RS15485	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS15495	COG0251	oxidation-reduction process
BC350_RS15500	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BC350_RS15510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BC350_RS15515	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BC350_RS15520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BC350_RS15525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BC350_RS15530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BC350_RS15535	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BC350_RS15535	COG0072	phenylalanine-tRNA ligase activity
BC350_RS15540	COG0776	regulation of translation
BC350_RS15565	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BC350_RS15570	COG0531	amino acid
BC350_RS15590	COG1846	Transcriptional regulator
BC350_RS15600	COG0402	S-adenosylhomocysteine deaminase activity
BC350_RS15610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BC350_RS15615	COG4566	intracellular signal transduction
BC350_RS15630	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BC350_RS15635	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC350_RS15645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC350_RS15660	COG0123	including yeast histone deacetylase and acetoin utilization protein
BC350_RS15685	COG1414	Transcriptional regulator
BC350_RS15710	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BC350_RS15715	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BC350_RS15735	COG0167	dihydroorotate dehydrogenase activity
BC350_RS15745	COG3158	transport of potassium into the cell
BC350_RS15755	COG2183	response to ionizing radiation
BC350_RS15770	COG1199	ATP-dependent helicase activity
BC350_RS15795	COG3243	poly(R)-hydroxyalkanoic acid synthase
BC350_RS15800	COG0183	Belongs to the thiolase family
BC350_RS15805	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS15815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC350_RS15820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BC350_RS15825	COG0183	Belongs to the thiolase family
BC350_RS15840	COG0560	Phosphoserine phosphatase
BC350_RS15850	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BC350_RS15855	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BC350_RS15860	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BC350_RS15865	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BC350_RS15870	COG0450	alkyl hydroperoxide reductase
BC350_RS15900	COG1562	ergosterol biosynthetic process
BC350_RS15905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS15925	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS15925	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BC350_RS15930	COG0544	peptidyl-prolyl cis-trans isomerase activity
BC350_RS15935	COG0740	serine-type endopeptidase activity
BC350_RS15940	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BC350_RS15945	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BC350_RS15950	COG0776	regulation of translation
BC350_RS15970	COG3385	transposase activity
BC350_RS15985	COG4181	ATPase activity
BC350_RS15990	COG0166	Belongs to the GPI family
BC350_RS15995	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BC350_RS16005	COG0047	phosphoribosylformylglycinamidine synthase activity
BC350_RS16005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BC350_RS16025	COG0535	radical SAM domain protein
BC350_RS16045	COG0583	DNA-binding transcription factor activity
BC350_RS16050	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS16060	COG1176	ABC-type spermidine putrescine transport system, permease component I
BC350_RS16070	COG3842	ATPase activity
BC350_RS16075	COG0642	Histidine kinase
BC350_RS16090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BC350_RS16115	COG1126	abc transporter atp-binding protein
BC350_RS16120	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC350_RS16130	COG2917	probably involved in intracellular septation
BC350_RS16135	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BC350_RS16140	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
BC350_RS16145	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS16155	COG0559	Belongs to the binding-protein-dependent transport system permease family
BC350_RS16185	COG0833	amino acid
BC350_RS16190	COG0833	amino acid
BC350_RS16200	COG1335	isochorismatase
BC350_RS16205	COG0183	Belongs to the thiolase family
BC350_RS16210	COG1960	acyl-CoA dehydrogenase activity
BC350_RS16215	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS16230	COG2130	NADP-dependent
BC350_RS16250	COG0596	Alpha beta hydrolase
BC350_RS16290	COG2831	hemolysin activation secretion protein
BC350_RS16310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BC350_RS16315	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BC350_RS16320	COG0470	DNA polymerase III
BC350_RS16330	COG0084	hydrolase, TatD family'
BC350_RS16345	COG1609	Transcriptional regulator
BC350_RS16350	COG1840	ABC-type Fe3 transport system, periplasmic component
BC350_RS16360	COG4208	sulfate ABC transporter
BC350_RS16365	COG3842	ATPase activity
BC350_RS16370	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC350_RS16375	COG3023	N-Acetylmuramoyl-L-alanine amidase
BC350_RS16410	COG0038	chloride channel
BC350_RS16415	COG2226	methyltransferase
BC350_RS16430	COG4771	TonB-dependent receptor
BC350_RS16435	COG2375	cellular response to nickel ion
BC350_RS16435	COG1132	(ABC) transporter
BC350_RS16450	COG3433	isochorismatase activity
BC350_RS16450	COG2226	methyltransferase
BC350_RS16450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC350_RS16465	COG2201	protein-glutamate methylesterase activity
BC350_RS16470	COG0456	acetyltransferase
BC350_RS16515	COG0179	Fumarylacetoacetate (FAA) hydrolase
BC350_RS16560	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
BC350_RS16590	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BC350_RS16600	COG2801	Transposase and inactivated derivatives
BC350_RS16720	COG2814	Major facilitator Superfamily
BC350_RS16745	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BC350_RS16755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC350_RS16800	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BC350_RS16805	COG0156	8-amino-7-oxononanoate synthase activity
BC350_RS16840	COG3045	CreA protein
BC350_RS16875	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BC350_RS16890	COG0840	transmembrane signaling receptor activity
BC350_RS16900	COG3387	PFAM Glycoside hydrolase 15-related
BC350_RS16925	COG0488	(ABC) transporter
BC350_RS16930	COG1619	proteins homologs of microcin C7 resistance protein MccF
BC350_RS16940	COG0720	synthase
BC350_RS16945	COG0602	queuosine metabolic process
BC350_RS16965	COG3550	peptidyl-serine autophosphorylation
BC350_RS16985	COG3485	protocatechuate 3,4-dioxygenase
BC350_RS16990	COG3485	protocatechuate 3,4-dioxygenase
BC350_RS16995	COG0583	DNA-binding transcription factor activity
BC350_RS17040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BC350_RS17040	COG0519	Catalyzes the synthesis of GMP from XMP
BC350_RS17055	COG0697	spore germination
BC350_RS17065	COG2914	Belongs to the UPF0125 (RnfH) family
BC350_RS17070	COG2867	negative regulation of translational initiation
BC350_RS17075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BC350_RS17080	COG0330	HflC and HflK could
BC350_RS17095	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
BC350_RS17100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BC350_RS17105	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BC350_RS17110	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC350_RS17115	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC350_RS17120	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BC350_RS17125	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BC350_RS17145	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BC350_RS17150	COG0575	Belongs to the CDS family
BC350_RS17155	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BC350_RS17160	COG0233	cytoplasmic translational termination
BC350_RS17165	COG0528	UMP kinase activity
BC350_RS17170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BC350_RS17175	COG0052	Belongs to the universal ribosomal protein uS2 family
BC350_RS17180	COG0024	Methionine aminopeptidase
BC350_RS17185	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BC350_RS17190	COG1187	pseudouridine synthase activity
BC350_RS17200	COG0242	peptide deformylase activity
BC350_RS17205	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BC350_RS17220	COG0596	Alpha beta hydrolase
BC350_RS17235	COG2171	N-acyltransferase activity
BC350_RS17245	COG1393	Belongs to the ArsC family
BC350_RS17250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC350_RS17260	COG2890	protein-(glutamine-N5) methyltransferase activity
BC350_RS17265	COG0302	gtp cyclohydrolase
BC350_RS17290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BC350_RS17295	COG0601	transmembrane transport
BC350_RS17300	COG0747	negative chemotaxis
BC350_RS17305	COG4172	Belongs to the ABC transporter superfamily
BC350_RS17320	COG0488	(ABC) transporter
BC350_RS17325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC350_RS17330	COG1683	Conserved Protein
BC350_RS17335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC350_RS17345	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BC350_RS17350	COG0477	Major facilitator Superfamily
BC350_RS17355	COG1573	uracil-dna glycosylase
BC350_RS17365	COG1214	PFAM Peptidase M22, glycoprotease
BC350_RS17375	COG2814	Major facilitator Superfamily
BC350_RS17400	COG0583	DNA-binding transcription factor activity
BC350_RS17410	COG2224	Isocitrate lyase
BC350_RS17430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BC350_RS17460	COG0583	DNA-binding transcription factor activity
BC350_RS17465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BC350_RS17470	COG4208	sulfate ABC transporter
BC350_RS17495	COG1116	anion transmembrane transporter activity
BC350_RS17500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC350_RS17505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC350_RS17510	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC350_RS17515	COG0431	NADPH-dependent FMN reductase
BC350_RS17520	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BC350_RS17525	COG0542	response to heat
BC350_RS17535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BC350_RS17540	COG0314	molybdopterin synthase activity
BC350_RS17545	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BC350_RS17550	COG0303	'Molybdopterin
BC350_RS17555	COG1573	uracil-dna glycosylase
BC350_RS17570	COG0436	Aminotransferase
BC350_RS17580	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BC350_RS17585	COG2076	Multidrug Resistance protein
BC350_RS17590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BC350_RS17605	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BC350_RS17605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC350_RS17615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BC350_RS17620	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BC350_RS17630	COG0791	NLP P60 protein
BC350_RS17635	COG0306	phosphate transporter
BC350_RS17645	COG0305	Participates in initiation and elongation during chromosome replication
BC350_RS17650	COG0359	binds to the 23S rRNA
BC350_RS17655	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BC350_RS17665	COG0360	Binds together with S18 to 16S ribosomal RNA
BC350_RS17680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BC350_RS17695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC350_RS17710	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BC350_RS17715	COG1024	Enoyl-CoA hydratase
BC350_RS17725	COG1217	gtp-binding protein TYPA
BC350_RS17745	COG2814	Major facilitator Superfamily
BC350_RS17750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BC350_RS17755	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BC350_RS17760	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BC350_RS17765	COG2251	uridine kinase activity
BC350_RS17765	COG0195	Participates in both transcription termination and antitermination
BC350_RS17770	COG0779	Required for maturation of 30S ribosomal subunits
BC350_RS17775	COG1187	pseudouridine synthase activity
BC350_RS17780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BC350_RS17790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BC350_RS17825	COG3278	Belongs to the heme-copper respiratory oxidase family
BC350_RS17835	COG2217	Heavy metal translocating P-type atpase
BC350_RS17845	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BC350_RS17850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BC350_RS17855	COG0508	dehydrogenase complex catalyzes the overall conversion of
BC350_RS17860	COG0567	Dehydrogenase, E1 component
BC350_RS17865	COG0584	glycerophosphoryl diester phosphodiesterase
BC350_RS17870	COG3842	ATPase activity
BC350_RS17880	COG1175	transmembrane transport
BC350_RS17885	COG1653	transport
BC350_RS17915	COG0174	glutamine synthetase
BC350_RS17925	COG1058	Belongs to the CinA family
BC350_RS17925	COG1546	Belongs to the CinA family
BC350_RS17950	COG1643	Atp-dependent helicase
BC350_RS17955	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
BC350_RS17955	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BC350_RS17960	COG1737	Transcriptional regulator
BC350_RS17965	COG0673	inositol 2-dehydrogenase activity
BC350_RS17975	COG0673	inositol 2-dehydrogenase activity
BC350_RS17985	COG1082	Xylose isomerase domain protein TIM barrel
BC350_RS17990	COG1172	Belongs to the binding-protein-dependent transport system permease family
BC350_RS17995	COG1129	ABC transporter
BC350_RS18005	COG3039	Transposase
BC350_RS18010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BC350_RS18015	COG3962	Belongs to the TPP enzyme family
BC350_RS18025	COG3718	enzyme involved in inositol metabolism
BC350_RS18035	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BC350_RS18085	COG3039	Transposase
BC350_RS18095	COG2916	Histone family protein nucleoid-structuring protein H-NS
BC350_RS18205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BC350_RS18215	COG3039	Transposase
BC350_RS18285	COG3621	Patatin-like phospholipase
BC350_RS18295	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BC350_RS18360	COG0402	S-adenosylhomocysteine deaminase activity
BC350_RS18415	COG3039	Transposase
BC350_RS18420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BC350_RS18465	COG2910	NAD(P)H-binding
BC350_RS18485	COG0443	Heat shock 70 kDa protein
BC350_RS18490	COG1914	H( )-stimulated, divalent metal cation uptake system
BC350_RS18495	COG3706	GGDEF domain
BC350_RS18520	COG0668	transmembrane transport
BC350_RS18540	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC350_RS18555	COG0840	transmembrane signaling receptor activity
BC350_RS18565	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC350_RS18610	COG0537	adenosine 5'-monophosphoramidase activity
BC350_RS18645	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BC350_RS18670	COG2423	ornithine cyclodeaminase activity
BC350_RS18675	COG1522	sequence-specific DNA binding
BC350_RS18680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC350_RS18685	COG0765	amino acid transport
BC350_RS18695	COG0583	DNA-binding transcription factor activity
BC350_RS18705	COG1902	pentaerythritol trinitrate reductase activity
BC350_RS18755	COG0583	DNA-binding transcription factor activity
BC350_RS18780	COG2814	Major facilitator Superfamily
BC350_RS18785	COG1126	abc transporter atp-binding protein
BC350_RS18805	COG0019	diaminopimelate decarboxylase activity
BC350_RS18815	COG4264	IucA IucC family
BC350_RS18820	COG4264	IucA IucC family
BC350_RS18830	COG4264	IucA IucC family
BC350_RS18835	COG2423	ornithine cyclodeaminase activity
BC350_RS18840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BC350_RS18855	COG4774	siderophore transport
BC350_RS18865	COG2223	nitrite transmembrane transporter activity
BC350_RS18955	COG0840	transmembrane signaling receptor activity
BC350_RS18960	COG0567	Dehydrogenase, E1 component
BC350_RS18965	COG0204	Acyl-transferase
BC350_RS18980	COG4263	nitrous-oxide reductase activity
BC350_RS19025	COG2831	hemolysin activation secretion protein
BC350_RS19060	COG2824	Alkylphosphonate utilization operon protein PhnA
BC350_RS19070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BC350_RS19080	COG0762	integral membrane protein
BC350_RS19105	COG1191	sigma factor activity
BC350_RS19120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC350_RS19135	COG2271	Major facilitator Superfamily
BC350_RS19140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BC350_RS19145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BC350_RS19150	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS19160	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
BC350_RS19165	COG0745	RESPONSE REGULATOR receiver
BC350_RS19170	COG2201	protein-glutamate methylesterase activity
BC350_RS19175	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BC350_RS19190	COG0835	chemotaxis
BC350_RS19200	COG0745	RESPONSE REGULATOR receiver
BC350_RS19205	COG1360	Flagellar Motor Protein
BC350_RS19240	COG0477	Major facilitator Superfamily
BC350_RS19245	COG2267	carboxylic ester hydrolase activity
BC350_RS19250	COG0300	oxidoreductase activity
BC350_RS19250	COG3321	synthase
BC350_RS19250	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS19250	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS19250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC350_RS19270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BC350_RS19280	COG0644	oxidoreductase
BC350_RS19285	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BC350_RS19290	COG3486	L-lysine 6-monooxygenase (NADPH) activity
BC350_RS19320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS19320	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BC350_RS19335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC350_RS19360	COG1045	serine acetyltransferase
BC350_RS19390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BC350_RS19400	COG0469	pyruvate kinase activity
BC350_RS19410	COG0583	DNA-binding transcription factor activity
BC350_RS19420	COG2205	protein histidine kinase activity
BC350_RS19425	COG0745	RESPONSE REGULATOR receiver
BC350_RS19435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS19445	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BC350_RS19470	COG1136	(ABC) transporter
BC350_RS19475	COG0577	efflux transmembrane transporter activity
BC350_RS19475	COG1136	(ABC) transporter
BC350_RS19515	COG0667	Aldo Keto reductase
BC350_RS19590	COG2192	nodulation
BC350_RS19605	COG2192	nodulation
BC350_RS19630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BC350_RS19630	COG4651	solute:proton antiporter activity
BC350_RS19655	COG3039	Transposase
BC350_RS19680	COG3256	nitric oxide reductase
BC350_RS19685	COG2188	Transcriptional regulator
BC350_RS19690	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BC350_RS19695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BC350_RS19730	COG0583	DNA-binding transcription factor activity
BC350_RS19785	COG0705	Rhomboid family
BC350_RS19805	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
BC350_RS19825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC350_RS19840	COG3210	domain, Protein
BC350_RS19845	COG3210	domain, Protein
BC350_RS19855	COG3210	domain, Protein
BC350_RS19885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BC350_RS19890	COG0642	Histidine kinase
BC350_RS19910	COG0837	glucose binding
BC350_RS19920	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BC350_RS19930	COG0589	response to stress
BC350_RS19945	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BC350_RS19950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BC350_RS19960	COG1845	cytochrome c oxidase, subunit III
BC350_RS19985	COG2271	Major facilitator Superfamily
BC350_RS20000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC350_RS20010	COG0765	amino acid transport
BC350_RS20015	COG0010	Belongs to the arginase family
BC350_RS20020	COG2197	response regulator
BC350_RS20055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BC350_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS20070	COG0583	DNA-binding transcription factor activity
BC350_RS20075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS20080	COG2814	Major facilitator Superfamily
BC350_RS20095	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS20100	COG1538	Outer membrane efflux protein
BC350_RS20155	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS20160	COG0473	3-isopropylmalate dehydrogenase activity
BC350_RS20170	COG2271	Major facilitator Superfamily
BC350_RS20175	COG2721	sulfolactate sulfo-lyase activity
BC350_RS20185	COG1475	DNA binding
BC350_RS20195	COG3969	phosphoadenosine phosphosulfate
BC350_RS20200	COG5295	Hep Hag repeat protein
BC350_RS20210	COG2205	protein histidine kinase activity
BC350_RS20210	COG0784	Response regulator, receiver
BC350_RS20215	COG2203	Gaf domain
BC350_RS20215	COG5001	Diguanylate cyclase
BC350_RS20215	COG4251	negative regulation of phosphorylation
BC350_RS20215	COG3706	GGDEF domain
BC350_RS20225	COG2801	Transposase and inactivated derivatives
BC350_RS20255	COG4213	ABC transporter substrate-binding protein
BC350_RS20260	COG1129	ABC transporter
BC350_RS20265	COG4214	carbohydrate transport
BC350_RS20270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC350_RS20275	COG1609	Transcriptional regulator
BC350_RS20370	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BC350_RS20380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC350_RS20390	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BC350_RS20415	COG2204	response regulator
BC350_RS20430	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BC350_RS20450	COG2205	protein histidine kinase activity
BC350_RS20460	COG2252	PERMEase
BC350_RS20470	COG1278	Cold shock
BC350_RS20495	COG0477	Major facilitator Superfamily
BC350_RS20500	COG4191	Histidine kinase
BC350_RS20510	COG4377	Putative membrane peptidase family (DUF2324)
BC350_RS20520	COG3447	MASE1 domain protein
BC350_RS20520	COG5001	Diguanylate cyclase
BC350_RS20520	COG5002	protein histidine kinase activity
BC350_RS20565	COG0038	chloride channel
BC350_RS20580	COG1881	PFAM PEBP family protein
BC350_RS20650	COG0582	viral genome integration into host DNA
BC350_RS20665	COG2916	Histone family protein nucleoid-structuring protein H-NS
BC350_RS20690	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS20700	COG1024	Enoyl-CoA hydratase
BC350_RS20705	COG1960	acyl-CoA dehydrogenase activity
BC350_RS20770	COG0477	Major facilitator Superfamily
BC350_RS20775	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BC350_RS20785	COG2814	Major facilitator Superfamily
BC350_RS20855	COG0725	ABC transporter, periplasmic molybdate-binding protein
BC350_RS20870	COG0714	Associated with various cellular activities
BC350_RS20885	COG0288	reversible hydration of carbon dioxide
BC350_RS20890	COG0659	secondary active sulfate transmembrane transporter activity
BC350_RS20940	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BC350_RS20950	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
BC350_RS20955	COG2944	sequence-specific DNA binding
BC350_RS20970	COG0210	DNA helicase
BC350_RS20995	COG0697	spore germination
BC350_RS21020	COG4677	pectinesterase activity
BC350_RS21035	COG4968	Prepilin-type N-terminal cleavage methylation domain
BC350_RS21045	COG4796	Type ii and iii secretion system protein
BC350_RS21070	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BC350_RS21100	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
BC350_RS21110	COG0534	Mate efflux family protein
BC350_RS21115	COG3251	PFAM MbtH domain protein
BC350_RS21130	COG0529	Catalyzes the synthesis of activated sulfate
BC350_RS21165	COG1104	cysteine desulfurase activity
BC350_RS21225	COG2706	6-phosphogluconolactonase activity
BC350_RS21250	COG0730	response to heat
BC350_RS21290	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BC350_RS21300	COG0028	Belongs to the TPP enzyme family
BC350_RS21315	COG1607	acyl-coa hydrolase
BC350_RS21365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BC350_RS21385	COG3039	Transposase
BC350_RS21410	COG1846	Transcriptional regulator
BC350_RS21415	COG1024	Enoyl-CoA hydratase
BC350_RS21420	COG1012	belongs to the aldehyde dehydrogenase family
BC350_RS21450	COG0657	acetylesterase activity
BC350_RS21460	COG2814	Major facilitator Superfamily
BC350_RS21470	COG1640	4-alpha-glucanotransferase
BC350_RS21475	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BC350_RS21485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BC350_RS21490	COG0366	Alpha amylase catalytic
BC350_RS21495	COG0366	Alpha amylase catalytic
BC350_RS21500	COG0297	glycogen (starch) synthase activity
BC350_RS21510	COG4771	TonB-dependent receptor
BC350_RS21520	COG3634	alkyl hydroperoxide reductase activity
BC350_RS21525	COG0735	belongs to the Fur family
BC350_RS21545	COG1918	ferrous iron import across plasma membrane
BC350_RS21545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BC350_RS21555	COG5002	protein histidine kinase activity
BC350_RS21555	COG5001	Diguanylate cyclase
BC350_RS21555	COG3447	MASE1 domain protein
BC350_RS21565	COG0840	transmembrane signaling receptor activity
BC350_RS21585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BC350_RS21600	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BC350_RS21610	COG0454	-acetyltransferase
BC350_RS21610	COG0456	acetyltransferase
BC350_RS21675	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
BC350_RS21695	COG3706	GGDEF domain
BC350_RS21700	COG0531	amino acid
BC350_RS21705	COG0534	Mate efflux family protein
BC350_RS21720	COG2197	response regulator
BC350_RS21730	COG1649	PFAM Uncharacterised BCR, COG1649
BC350_RS21730	COG0726	polysaccharide deacetylase
BC350_RS21735	COG1215	transferase activity, transferring glycosyl groups
BC350_RS21750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS21755	COG2274	protein secretion by the type I secretion system
BC350_RS21785	COG0840	transmembrane signaling receptor activity
BC350_RS21795	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS21805	COG2070	2-Nitropropane dioxygenase
BC350_RS21810	COG0583	DNA-binding transcription factor activity
BC350_RS21815	COG1695	Transcriptional regulator
BC350_RS21830	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC350_RS21835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS21840	COG0745	RESPONSE REGULATOR receiver
BC350_RS21860	COG0589	response to stress
BC350_RS21875	COG0789	Transcriptional regulator
BC350_RS21885	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BC350_RS21910	COG1764	response to oxidative stress
BC350_RS21925	COG0473	3-isopropylmalate dehydrogenase activity
BC350_RS21960	COG2916	Histone family protein nucleoid-structuring protein H-NS
BC350_RS21965	COG2188	Transcriptional regulator
BC350_RS21970	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS21975	COG2197	response regulator
BC350_RS21995	COG1815	bacterial-type flagellum-dependent cell motility
BC350_RS22005	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BC350_RS22010	COG1749	Flagellar hook protein flgE
BC350_RS22015	COG4787	bacterial-type flagellum-dependent cell motility
BC350_RS22025	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BC350_RS22030	COG1706	bacterial-type flagellum-dependent cell motility
BC350_RS22040	COG1256	bacterial-type flagellum assembly
BC350_RS22060	COG2226	methyltransferase
BC350_RS22075	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC350_RS22080	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS22090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BC350_RS22110	COG2986	histidine ammonia-lyase
BC350_RS22120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC350_RS22130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BC350_RS22140	COG0204	Acyl-transferase
BC350_RS22155	COG1987	bacterial-type flagellum assembly
BC350_RS22160	COG1338	Plays a role in the flagellum-specific transport system
BC350_RS22220	COG1846	Transcriptional regulator
BC350_RS22235	COG1677	Flagellar hook-basal body complex protein FliE
BC350_RS22245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BC350_RS22280	COG3706	GGDEF domain
BC350_RS22280	COG4251	negative regulation of phosphorylation
BC350_RS22280	COG5001	Diguanylate cyclase
BC350_RS22280	COG2203	Gaf domain
BC350_RS22305	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
BC350_RS22325	COG2814	Major facilitator Superfamily
BC350_RS22335	COG0583	DNA-binding transcription factor activity
BC350_RS22355	COG0251	oxidation-reduction process
BC350_RS22370	COG0640	Transcriptional regulator
BC350_RS22385	COG1522	sequence-specific DNA binding
BC350_RS22395	COG0251	oxidation-reduction process
BC350_RS22455	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC350_RS22480	COG0683	leucine binding
BC350_RS22500	COG3766	membrane
BC350_RS22520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BC350_RS22560	COG1609	Transcriptional regulator
BC350_RS22570	COG1621	beta-fructofuranosidase activity
BC350_RS22595	COG0114	fumarate hydratase activity
BC350_RS22600	COG0477	Major facilitator Superfamily
BC350_RS22620	COG1742	UPF0060 membrane protein
BC350_RS22625	COG0668	transmembrane transport
BC350_RS22655	COG0730	response to heat
BC350_RS22660	COG0583	DNA-binding transcription factor activity
BC350_RS22670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC350_RS22675	COG0730	response to heat
BC350_RS22680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BC350_RS22705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
BC350_RS22725	COG3550	peptidyl-serine autophosphorylation
BC350_RS22760	COG0251	oxidation-reduction process
BC350_RS22770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BC350_RS22775	COG1294	oxidase, subunit
BC350_RS22780	COG1271	oxidase subunit
BC350_RS22790	COG2951	lytic endotransglycosylase activity
BC350_RS22825	COG0473	3-isopropylmalate dehydrogenase activity
BC350_RS22825	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BC350_RS22830	COG0436	Aminotransferase
BC350_RS22835	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BC350_RS22860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BC350_RS22870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BC350_RS22875	COG0840	transmembrane signaling receptor activity
BC350_RS22880	COG2223	nitrite transmembrane transporter activity
BC350_RS22885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC350_RS22895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BC350_RS22900	COG0243	molybdopterin cofactor binding
BC350_RS22915	COG0534	Mate efflux family protein
BC350_RS22925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BC350_RS22935	COG0840	transmembrane signaling receptor activity
BC350_RS22940	COG5001	Diguanylate cyclase
BC350_RS22940	COG3300	MHYT domain
BC350_RS22945	COG1271	oxidase subunit
BC350_RS22950	COG1294	oxidase, subunit
BC350_RS23020	COG2197	response regulator
BC350_RS23025	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BC350_RS23030	COG0800	Aldolase
BC350_RS23045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
BC350_RS23070	COG2274	protein secretion by the type I secretion system
BC350_RS23115	COG1858	cytochrome C peroxidase
BC350_RS23120	COG1253	flavin adenine dinucleotide binding
BC350_RS23140	COG1858	cytochrome C peroxidase
BC350_RS23170	COG2205	protein histidine kinase activity
BC350_RS23175	COG0745	RESPONSE REGULATOR receiver
BC350_RS23190	COG3813	Protein conserved in bacteria
BC350_RS23225	COG1942	4-Oxalocrotonate Tautomerase
BC350_RS23230	COG2267	carboxylic ester hydrolase activity
BC350_RS23245	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BC350_RS23250	COG4149	molybdate abc transporter
BC350_RS23255	COG2066	Belongs to the glutaminase family
BC350_RS23265	COG2197	response regulator
BC350_RS23285	COG5444	nuclease activity
BC350_RS23315	COG0640	Transcriptional regulator
BC350_RS23320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC350_RS23325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BC350_RS23335	COG1064	alcohol dehydrogenase
BC350_RS23360	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
BC350_RS23385	COG1064	alcohol dehydrogenase
BC350_RS23395	COG0583	DNA-binding transcription factor activity
BC350_RS23405	COG3321	synthase
BC350_RS23405	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS23405	COG0604	alcohol dehydrogenase
BC350_RS23420	COG2030	dehydratase
BC350_RS23475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS23485	COG0583	DNA-binding transcription factor activity
BC350_RS23505	COG1846	Transcriptional regulator
BC350_RS23510	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BC350_RS23515	COG1877	trehalose-phosphatase activity
BC350_RS23520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BC350_RS23525	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BC350_RS23550	COG2197	response regulator
BC350_RS23590	COG4964	Belongs to the GSP D family
BC350_RS23650	COG0673	inositol 2-dehydrogenase activity
BC350_RS23655	COG2831	hemolysin activation secretion protein
BC350_RS23685	COG0673	inositol 2-dehydrogenase activity
BC350_RS23695	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS23700	COG4689	acetoacetate decarboxylase
BC350_RS23710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BC350_RS23725	COG1278	Cold shock
BC350_RS23730	COG3158	transport of potassium into the cell
BC350_RS23735	COG3300	MHYT domain
BC350_RS23735	COG5001	Diguanylate cyclase
BC350_RS23740	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BC350_RS23750	COG0243	molybdopterin cofactor binding
BC350_RS23755	COG2223	nitrite transmembrane transporter activity
BC350_RS23780	COG0745	RESPONSE REGULATOR receiver
BC350_RS23815	COG3220	belongs to the UPF0276 family
BC350_RS23860	COG0840	transmembrane signaling receptor activity
BC350_RS23900	COG1596	polysaccharide export
BC350_RS23905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BC350_RS23910	COG3206	protein involved in exopolysaccharide biosynthesis
BC350_RS23910	COG0489	protein tyrosine kinase activity
BC350_RS23915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BC350_RS23920	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
BC350_RS23925	COG2244	polysaccharide biosynthetic process
BC350_RS23940	COG0110	maltose O-acetyltransferase activity
BC350_RS23960	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BC350_RS24015	COG0583	DNA-binding transcription factor activity
BC350_RS24025	COG1301	dicarboxylic acid transport
BC350_RS24030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BC350_RS24050	COG1999	signal sequence binding
BC350_RS24065	COG1454	alcohol dehydrogenase
BC350_RS24070	COG0477	Major facilitator Superfamily
BC350_RS24075	COG0352	thiamine-phosphate diphosphorylase activity
BC350_RS24095	COG2197	response regulator
BC350_RS24100	COG3850	Histidine kinase
BC350_RS24105	COG1763	Mo-molybdopterin cofactor biosynthetic process
BC350_RS24110	COG2181	nitrate reductase activity
BC350_RS24115	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BC350_RS24120	COG1140	nitrate reductase beta subunit
BC350_RS24125	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BC350_RS24130	COG2223	nitrite transmembrane transporter activity
BC350_RS24145	COG0826	peptidase U32
BC350_RS24150	COG0826	peptidase U32
BC350_RS24155	COG3154	lipid carrier protein
BC350_RS24180	COG1396	sequence-specific DNA binding
BC350_RS24190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC350_RS24195	COG3604	Transcriptional regulator
BC350_RS24200	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
BC350_RS24240	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BC350_RS24260	COG1063	alcohol dehydrogenase
BC350_RS24265	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS24270	COG3265	gluconokinase activity
BC350_RS24275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BC350_RS24280	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BC350_RS24285	COG0436	Aminotransferase
BC350_RS24295	COG0511	ligase activity, forming carbon-carbon bonds
BC350_RS24305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BC350_RS24310	COG1984	allophanate hydrolase subunit 2
BC350_RS24320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BC350_RS24325	COG4221	oxidoreductase activity
BC350_RS24330	COG0765	amino acid transport
BC350_RS24335	COG0765	amino acid transport
BC350_RS24340	COG1126	abc transporter atp-binding protein
BC350_RS24345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BC350_RS24365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BC350_RS24390	COG2801	Transposase and inactivated derivatives
BC350_RS24400	COG0745	RESPONSE REGULATOR receiver
BC350_RS24420	COG1309	transcriptional regulator
BC350_RS24440	COG0583	DNA-binding transcription factor activity
BC350_RS24445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BC350_RS24470	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
BC350_RS24500	COG1674	ftsk spoiiie
BC350_RS24520	COG5434	Belongs to the glycosyl hydrolase 28 family
BC350_RS24545	COG4886	Leucine-rich repeat (LRR) protein
BC350_RS24550	COG1450	Type ii and iii secretion system protein
BC350_RS24555	COG2207	Transcriptional regulator
BC350_RS24600	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BC350_RS24605	COG4789	Type iii secretion
BC350_RS24620	COG4790	Type iii secretion
BC350_RS24660	COG0745	RESPONSE REGULATOR receiver
BC350_RS24665	COG2197	response regulator
BC350_RS24675	COG1595	DNA-templated transcription, initiation
BC350_RS24725	COG0840	transmembrane signaling receptor activity
BC350_RS24750	COG1051	belongs to the nudix hydrolase family
BC350_RS24750	COG1056	cytidyltransferase-related domain
BC350_RS24755	COG2271	Major facilitator Superfamily
BC350_RS24770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BC350_RS24775	COG2721	sulfolactate sulfo-lyase activity
BC350_RS24785	COG2271	Major facilitator Superfamily
BC350_RS24795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BC350_RS24800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BC350_RS24810	COG0583	DNA-binding transcription factor activity
BC350_RS24820	COG0697	spore germination
BC350_RS24835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BC350_RS24845	COG1309	transcriptional regulator
BC350_RS24855	COG0579	oxidoreductase
BC350_RS24870	COG4206	TonB-dependent receptor
BC350_RS24875	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BC350_RS24890	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BC350_RS24905	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BC350_RS24915	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BC350_RS24920	COG3620	sequence-specific DNA binding
BC350_RS24925	COG0587	DNA-directed DNA polymerase activity
BC350_RS24940	COG2814	Major facilitator Superfamily
BC350_RS24955	COG0436	Aminotransferase
BC350_RS24970	COG3321	synthase
BC350_RS24970	COG1028	Short-chain dehydrogenase reductase Sdr
BC350_RS24970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BC350_RS24970	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS24970	COG0300	oxidoreductase activity
BC350_RS24985	COG2192	nodulation
BC350_RS24990	COG0318	PFAM AMP-dependent synthetase and ligase
BC350_RS25015	COG0525	valine-tRNA ligase activity
BC350_RS25030	COG3916	Acyl-homoserine-lactone synthase
BC350_RS25035	COG2197	response regulator
BC350_RS25130	COG1649	PFAM Uncharacterised BCR, COG1649
BC350_RS25250	COG3039	Transposase
BC350_RS25275	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BC350_RS25295	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BC350_RS25320	COG1730	sister chromatid segregation
BC350_RS25325	COG1858	cytochrome C peroxidase
BC350_RS25410	COG1690	Belongs to the RtcB family
BC350_RS25415	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BC350_RS25430	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BC350_RS25440	COG3483	tryptophan 2,3-dioxygenase activity
BC350_RS25455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BC350_RS25475	COG1960	acyl-CoA dehydrogenase activity
BC350_RS25505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BC350_RS25510	COG0134	indole-3-glycerol-phosphate synthase activity
BC350_RS25515	COG0019	diaminopimelate decarboxylase activity
BC350_RS25520	COG0259	pyridoxamine-phosphate oxidase activity
BC350_RS25525	COG0583	DNA-binding transcription factor activity
BC350_RS25530	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BC350_RS25555	COG1024	Enoyl-CoA hydratase
BC350_RS25580	COG2807	transmembrane transport
BC350_RS25585	COG0519	Catalyzes the synthesis of GMP from XMP
BC350_RS25600	COG2814	Major facilitator Superfamily
BC350_RS25610	COG1335	isochorismatase
BC350_RS25620	COG1846	Transcriptional regulator
BC350_RS25655	COG0745	RESPONSE REGULATOR receiver
BC350_RS25660	COG5002	protein histidine kinase activity
BC350_RS25670	COG1960	acyl-CoA dehydrogenase activity
BC350_RS25675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BC350_RS25690	COG1024	Enoyl-CoA hydratase
BC350_RS25695	COG1024	Enoyl-CoA hydratase
BC350_RS25700	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BC350_RS25705	COG1522	sequence-specific DNA binding
BC350_RS25725	COG3251	PFAM MbtH domain protein
BC350_RS25730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BC350_RS25745	COG4941	Belongs to the sigma-70 factor family
BC350_RS25750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
BC350_RS25760	COG0438	transferase activity, transferring glycosyl groups
BC350_RS25805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
BC350_RS25810	COG3411	Ferredoxin
BC350_RS25825	COG1648	precorrin-2 dehydrogenase activity
BC350_RS25825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BC350_RS25835	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BC350_RS25870	COG1797	cobyrinic acid a,c-diamide synthase activity
BC350_RS25875	COG0778	Nitroreductase
BC350_RS25925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BC350_RS25930	COG2151	metal-sulfur cluster biosynthetic enzyme
BC350_RS25935	COG3396	Phenylacetate-CoA oxygenase
BC350_RS25940	COG3460	Phenylacetate-CoA oxygenase
BC350_RS25945	COG3396	Phenylacetate-CoA oxygenase
BC350_RS25975	COG0835	chemotaxis
BC350_RS25975	COG0784	Response regulator, receiver
BC350_RS25985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BC350_RS26015	COG0300	oxidoreductase activity
BC350_RS26035	COG5297	Belongs to the glycosyl hydrolase family 6
BC350_RS26040	COG3039	Transposase
BC350_RS26110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BC350_RS26135	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BC350_RS26145	COG3210	domain, Protein
BC350_RS26160	COG3210	domain, Protein