locus-tag	class	description
HWE45_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
HWE45_RS00010	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
HWE45_RS00015	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWE45_RS00025	ENOG4105F2I	Transposase
HWE45_RS00055	ENOG4105F2I	Transposase
HWE45_RS00100	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HWE45_RS00110	ENOG4105F7F	Chaperone
HWE45_RS00120	ENOG4105F2I	Transposase
HWE45_RS00135	ENOG4105FA0	parb-like partition protein
HWE45_RS00150	ENOG4105F2I	Transposase
HWE45_RS00185	ENOG4108IQK	o-acetylhomoserine
HWE45_RS00190	ENOG4105FFC	UPF0187 protein
HWE45_RS00200	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS00210	ENOG4105EAB	amino acid AbC transporter
HWE45_RS00215	ENOG4105E5Q	amino acid AbC transporter
HWE45_RS00220	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS00225	ENOG4105CJP	fad dependent oxidoreductase
HWE45_RS00240	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HWE45_RS00245	ENOG4105DHQ	Histidine kinase
HWE45_RS00260	ENOG4105FCW	Major Facilitator superfamily
HWE45_RS00280	ENOG4105KPV	Transcriptional regulator
HWE45_RS00305	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HWE45_RS00310	ENOG4105D2X	ABC transporter substrate-binding protein
HWE45_RS00335	ENOG4105D01	(LipO)protein
HWE45_RS00340	ENOG4105C08	Histidine kinase
HWE45_RS00345	ENOG4108R80	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)
HWE45_RS00350	ENOG4105C8X	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HWE45_RS00355	ENOG4105D9K	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)
HWE45_RS00370	ENOG4105F2I	Transposase
HWE45_RS00395	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
HWE45_RS00415	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HWE45_RS00425	ENOG4105D6S	protein involved in catabolism of external DNA
HWE45_RS00430	ENOG4108MXC	l-carnitine dehydratase bile acid-inducible protein F
HWE45_RS00440	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
HWE45_RS00445	ENOG4107QMS	site-determining protein
HWE45_RS00450	ENOG4105K7U	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
HWE45_RS00455	ENOG4107RNS	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic
HWE45_RS00465	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HWE45_RS00490	ENOG4105KZX	Pterin carbinolamine dehydratase
HWE45_RS00495	ENOG4105MIR	Phenylalanine 4-monooxygenase
HWE45_RS00500	ENOG4105EW9	transcriptional regulator AsnC family
HWE45_RS00510	ENOG4105F84	Ornithine cyclodeaminase
HWE45_RS00515	ENOG4105EIF	outer membrane protein W
HWE45_RS00525	ENOG4105C59	p-type ATPase
HWE45_RS00535	ENOG4105E8V	Alpha Beta Hydrolase Fold protein
HWE45_RS00545	ENOG4105C0Z	ABC transporter
HWE45_RS00550	ENOG4108IV0	ABC, transporter
HWE45_RS00560	ENOG4105C32	Amino acid ABC transporter (Permease)
HWE45_RS00600	ENOG4105VRT	cytoplasmic protein
HWE45_RS00605	ENOG4105CR8	Transcriptional regulator
HWE45_RS00625	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
HWE45_RS00630	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
HWE45_RS00635	ENOG4107QJE	Chromosome Partitioning Protein
HWE45_RS00640	ENOG4105FA0	parb-like partition protein
HWE45_RS00650	ENOG4107RAZ	it plays a direct role in the translocation of protons across the membrane (By similarity)
HWE45_RS00655	ENOG4105KY6	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HWE45_RS00660	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HWE45_RS00665	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
HWE45_RS00670	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
HWE45_RS00675	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
HWE45_RS00680	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
HWE45_RS00685	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
HWE45_RS00700	ENOG4105K4P	CoA-binding domain protein
HWE45_RS00720	ENOG4108K3A	Glutathione S-transferase
HWE45_RS00730	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS00750	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
HWE45_RS00755	ENOG4105C25	Primosomal protein n'
HWE45_RS00760	ENOG4105C26	Dehydrogenase
HWE45_RS00765	ENOG4105CP9	extracellular ligand-binding receptor
HWE45_RS00775	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
HWE45_RS00780	ENOG4105EPD	Oligopeptide transporter, Opt family
HWE45_RS00785	ENOG4105EJQ	L-serine dehydratase
HWE45_RS00790	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWE45_RS00795	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
HWE45_RS00800	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HWE45_RS00820	ENOG4105C4R	Atp-dependent dna helicase
HWE45_RS00840	ENOG4105VJY	transcriptional regulator
HWE45_RS00845	ENOG4105NNS	Autoinducer synthesis protein
HWE45_RS00855	ENOG4105D4P	Coproporphyrinogen iii oxidase
HWE45_RS00860	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HWE45_RS00865	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HWE45_RS00870	ENOG41060W2	glyoxylate carboligase
HWE45_RS00875	ENOG4105EJC	lysr family transcriptional regulator
HWE45_RS00890	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
HWE45_RS00900	ENOG4105CK2	sodium dicarboxylate symporter
HWE45_RS00905	ENOG4105DHG	Allantoate amidinohydrolase
HWE45_RS00915	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HWE45_RS00940	ENOG4105C5X	domain protein
HWE45_RS00950	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HWE45_RS00955	ENOG41082RQ	UPF0102 protein
HWE45_RS00970	ENOG4107S7U	Sulfide dehydrogenase
HWE45_RS00975	ENOG4108594	Permease of the drug metabolite transporter
HWE45_RS00980	ENOG4105W2Z	cytochrome C, class I
HWE45_RS01005	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
HWE45_RS01010	ENOG4107QX9	Thiol disulfide interChange protein
HWE45_RS01015	ENOG4105CGH	5'-nucleotidase
HWE45_RS01170	ENOG4105VT3	DNA binding domain protein, excisionase family
HWE45_RS01240	ENOG4105X54	addiction module antidote protein
HWE45_RS01265	ENOG4105CEC	DNA methylase N-4 N-6
HWE45_RS01365	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS01460	ENOG4105D5K	Hemolysin activator protein
HWE45_RS01465	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HWE45_RS01485	ENOG4105F2I	Transposase
HWE45_RS01510	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
HWE45_RS01515	ENOG4107SQD	Transcriptional regulator, GntR family
HWE45_RS01520	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HWE45_RS01535	ENOG4107UCJ	Catalyzes the synthesis of activated sulfate (By similarity)
HWE45_RS01550	ENOG4107RDJ	Sulfotransferase
HWE45_RS01575	ENOG4105BZ8	glutamate synthase
HWE45_RS01585	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS01590	ENOG4105VEQ	Cold shock protein
HWE45_RS01610	ENOG4105F2I	Transposase
HWE45_RS01695	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HWE45_RS01730	ENOG4105C5I	Dehydrogenase
HWE45_RS01740	ENOG4108JU9	GAF modulated sigma54 specific transcriptional regulator Fis family
HWE45_RS01745	ENOG4105C26	Dehydrogenase
HWE45_RS01750	ENOG4105CPD	ethanolamine ammonia-lyase
HWE45_RS01755	ENOG4107FQ9	ethanolamine ammonia-lyase
HWE45_RS01760	ENOG4105CJB	Exodeoxyribonuclease I
HWE45_RS01805	ENOG4105D7Q	type ii secretion system
HWE45_RS01810	ENOG4107QHF	type ii secretion system protein e
HWE45_RS01815	ENOG4105GVR	general secretion pathway protein D
HWE45_RS01840	ENOG4108WWZ	General secretion pathway protein J
HWE45_RS01850	ENOG4105VWV	general secretion pathway protein h
HWE45_RS01855	ENOG4108VAU	general secretion pathway protein G
HWE45_RS01875	ENOG4105F7P	transcriptional regulator AsnC family
HWE45_RS01880	ENOG4105EY9	peptidase S8 and S53, subtilisin, kexin, sedolisin
HWE45_RS01905	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HWE45_RS01930	ENOG4108Z9W	Outer membrane porin
HWE45_RS01935	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS01945	ENOG4105EEX	Two component transcriptional regulator (Winged helix family
HWE45_RS01950	ENOG4105VMH	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity)
HWE45_RS01995	ENOG4105ED4	portal protein
HWE45_RS02060	ENOG4105F2I	Transposase
HWE45_RS02065	ENOG4105F2I	Transposase
HWE45_RS02150	ENOG4107YVC	modification (methylase)
HWE45_RS02245	ENOG4108KU3	Integrase
HWE45_RS02275	ENOG4105BZU	Histidine kinase
HWE45_RS02280	ENOG41068CG	regulatoR
HWE45_RS02285	ENOG41076HS	cation diffusion facilitator family transporter
HWE45_RS02325	ENOG4105D8X	mechanosensitive ion channel
HWE45_RS02345	ENOG4107EXC	regulatoR
HWE45_RS02350	ENOG4105JJR	Histidine kinase
HWE45_RS02365	ENOG4105CSH	Transporter
HWE45_RS02370	ENOG4105CSH	Transporter
HWE45_RS02380	ENOG4105DJ9	glucan biosynthesis protein
HWE45_RS02385	ENOG4106A2Z	transcriptional regulator antitoxin, MazE
HWE45_RS02405	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
HWE45_RS02430	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS02440	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
HWE45_RS02445	ENOG4105E98	transcriptional regulator DeoR family
HWE45_RS02495	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HWE45_RS02515	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
HWE45_RS02520	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
HWE45_RS02525	ENOG4108VZM	50s ribosomal protein L10
HWE45_RS02530	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
HWE45_RS02535	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWE45_RS02540	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWE45_RS02545	ENOG4107FKF	Uncharacterized protein conserved in bacteria (DUF2138)
HWE45_RS02555	ENOG4107S52	alpha-2-macroglobulin domain protein
HWE45_RS02560	ENOG41081SK	signal peptide protein
HWE45_RS02565	ENOG4105EDV	vault protein
HWE45_RS02570	ENOG4105EDV	vault protein
HWE45_RS02580	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HWE45_RS02585	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
HWE45_RS02590	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
HWE45_RS02595	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
HWE45_RS02600	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
HWE45_RS02605	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
HWE45_RS02610	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
HWE45_RS02615	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
HWE45_RS02620	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
HWE45_RS02625	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWE45_RS02630	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
HWE45_RS02635	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
HWE45_RS02640	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
HWE45_RS02645	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
HWE45_RS02650	ENOG41084PQ	50s ribosomal protein l29
HWE45_RS02655	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
HWE45_RS02660	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
HWE45_RS02665	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
HWE45_RS02670	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWE45_RS02675	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
HWE45_RS02680	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
HWE45_RS02685	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
HWE45_RS02690	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
HWE45_RS02695	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
HWE45_RS02700	ENOG4105VPB	50S ribosomal protein L30
HWE45_RS02705	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
HWE45_RS02710	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
HWE45_RS02715	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HWE45_RS02720	ENOG41067V7	50S ribosomal protein L36
HWE45_RS02725	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWE45_RS02730	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
HWE45_RS02735	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
HWE45_RS02740	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
HWE45_RS02745	ENOG4108ZT0	50S ribosomal protein l17
HWE45_RS02755	ENOG4105CSG	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)
HWE45_RS02760	ENOG4105D52	delta-aminolevulinic acid dehydratase
HWE45_RS02765	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
HWE45_RS02770	ENOG4106RE7	Cytochrome
HWE45_RS02775	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
HWE45_RS02780	ENOG4105CRE	cytochrome C
HWE45_RS02800	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HWE45_RS02805	ENOG4105DQ2	Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)
HWE45_RS02810	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HWE45_RS02820	ENOG4105XQ6	frataxin-like protein
HWE45_RS02825	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS02830	ENOG4108JQC	penicillin-binding protein 1A
HWE45_RS02855	ENOG4105E4G	Type IV pilus
HWE45_RS02860	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
HWE45_RS02865	ENOG4105D49	3-dehydroquinate synthase
HWE45_RS02870	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
HWE45_RS02900	ENOG4105DHJ	ABC, transporter
HWE45_RS02905	ENOG4105CY3	ABC transporter, permease
HWE45_RS02910	ENOG4107PE3	Mammalian cell entry related domain protein
HWE45_RS02915	ENOG410903C	(LipO)protein
HWE45_RS02930	ENOG4105DA5	(ABC) transporter
HWE45_RS02935	ENOG4105E3A	(ABC) transporter
HWE45_RS02945	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
HWE45_RS02950	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
HWE45_RS02955	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
HWE45_RS02960	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HWE45_RS02965	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
HWE45_RS02970	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
HWE45_RS02975	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
HWE45_RS02980	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
HWE45_RS02985	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
HWE45_RS02990	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
HWE45_RS02995	ENOG4105KPZ	phosphoribosyl-atp pyrophosphatase
HWE45_RS03005	ENOG4105WKS	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
HWE45_RS03010	ENOG4107Z6S	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)
HWE45_RS03015	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
HWE45_RS03030	ENOG4105C4Y	ABC transporter
HWE45_RS03035	ENOG4105DHQ	Histidine kinase
HWE45_RS03050	ENOG4108Z9W	Outer membrane porin
HWE45_RS03055	ENOG4105C0H	protease
HWE45_RS03060	ENOG4107QNR	UPF0135 protein
HWE45_RS03065	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
HWE45_RS03070	ENOG4108R5F	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HWE45_RS03075	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
HWE45_RS03080	ENOG4105EIX	cytochrome c1
HWE45_RS03085	ENOG4107MKT	Stringent starvation protein a
HWE45_RS03090	ENOG4105KB2	stringent starvation protein b
HWE45_RS03105	ENOG4108MGY	Histidine kinase
HWE45_RS03115	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HWE45_RS03120	ENOG4105E0K	tonB-dependent siderophore receptor
HWE45_RS03125	ENOG4108S3W	Anti-feci sigma factor, fecr
HWE45_RS03135	ENOG4105E2S	oxidase) subunit II
HWE45_RS03140	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HWE45_RS03145	ENOG4105CCU	oxidase (Subunit III)
HWE45_RS03150	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
HWE45_RS03155	ENOG4105C5H	ABC transporter
HWE45_RS03175	ENOG4105C3A	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity)
HWE45_RS03180	ENOG4105DJ9	glucan biosynthesis protein
HWE45_RS03195	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
HWE45_RS03205	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
HWE45_RS03215	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
HWE45_RS03220	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
HWE45_RS03230	ENOG4105C3G	gtp-binding protein
HWE45_RS03265	ENOG4105D3Z	quinone oxidoreductase, yhdh yhfp family
HWE45_RS03290	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
HWE45_RS03300	ENOG4105DK0	Indole-3-glycerol phosphate synthase
HWE45_RS03305	ENOG4108I0Q	anthranilate phosphoribosyltransferase
HWE45_RS03315	ENOG4105DDQ	anthranilate synthase
HWE45_RS03325	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HWE45_RS03335	ENOG4105NWN	ApaG protein
HWE45_RS03355	ENOG4108ZJI	phenylacetic acid degradation protein
HWE45_RS03360	ENOG4108UKI	Enoyl-CoA hydratase
HWE45_RS03365	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS03395	ENOG4105CH2	amidohydrolase
HWE45_RS03405	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS03410	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS03415	ENOG4105C3U	ABC transporter
HWE45_RS03420	ENOG4108JQ7	(ABC) transporter
HWE45_RS03430	ENOG4105DM4	PTS System
HWE45_RS03435	ENOG4105DE4	1-phosphofructokinase
HWE45_RS03440	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HWE45_RS03445	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS03460	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS03465	ENOG4105CSH	Transporter
HWE45_RS03470	ENOG4108Z9W	Outer membrane porin
HWE45_RS03475	ENOG4108S0N	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)
HWE45_RS03480	ENOG4108V6E	Cell division protein mraZ
HWE45_RS03485	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
HWE45_RS03495	ENOG4105CJN	penicillin-binding protein
HWE45_RS03500	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
HWE45_RS03505	ENOG4108EQQ	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)
HWE45_RS03510	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HWE45_RS03515	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
HWE45_RS03525	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
HWE45_RS03530	ENOG4105DFU	Cell wall formation (By similarity)
HWE45_RS03535	ENOG4105CPF	Cell wall formation (By similarity)
HWE45_RS03540	ENOG4105K7E	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)
HWE45_RS03545	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
HWE45_RS03550	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
HWE45_RS03560	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWE45_RS03565	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS03575	ENOG4105DR5	peptidase
HWE45_RS03580	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
HWE45_RS03585	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
HWE45_RS03595	ENOG4105M6F	mutator MutT protein
HWE45_RS03600	ENOG41067SF	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)
HWE45_RS03605	ENOG4105DHA	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)
HWE45_RS03610	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
HWE45_RS03615	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
HWE45_RS03620	ENOG4105D7Q	type ii secretion system
HWE45_RS03625	ENOG4107QHF	type ii secretion system protein e
HWE45_RS03630	ENOG4108JU6	CBS domain protein
HWE45_RS03640	ENOG4105EAH	synthase
HWE45_RS03645	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
HWE45_RS03650	ENOG4105K46	50S ribosomal protein l27
HWE45_RS03655	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWE45_RS03660	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
HWE45_RS03670	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
HWE45_RS03675	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
HWE45_RS03680	ENOG4105E4C	Lytic transglycosylase catalytic
HWE45_RS03690	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
HWE45_RS03695	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
HWE45_RS03700	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWE45_RS03715	ENOG4107TUY	Histidine kinase
HWE45_RS03720	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS03725	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HWE45_RS03730	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HWE45_RS03735	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HWE45_RS03750	ENOG4105FKN	transcriptional regulator, AsnC family
HWE45_RS03760	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS03800	ENOG4107T4Z	adenosine kinase
HWE45_RS03805	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
HWE45_RS03815	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
HWE45_RS03820	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HWE45_RS03825	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HWE45_RS03830	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
HWE45_RS03835	ENOG4105K63	Thioredoxin
HWE45_RS03845	ENOG4105DFU	Cell wall formation (By similarity)
HWE45_RS03850	ENOG4105IPS	esterase
HWE45_RS03855	ENOG410807V	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)
HWE45_RS03870	ENOG4105E2X	shikimate dehydrogenase
HWE45_RS03875	ENOG4108VKV	Monofunctional biosynthetic peptidoglycan transglycosylase
HWE45_RS03885	ENOG4107QUT	magnesium and cobalt transport protein CorA
HWE45_RS03890	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
HWE45_RS03900	ENOG4105CEV	competence damage-inducible protein
HWE45_RS03905	ENOG4108ZAI	phosphatidylglycerophosphatase a
HWE45_RS03910	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
HWE45_RS03915	ENOG4105C6K	Malic enzyme
HWE45_RS03935	ENOG4105QF0	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
HWE45_RS03945	ENOG4105ETT	transcriptional Regulator, LysR family
HWE45_RS03950	ENOG4108Z9W	Outer membrane porin
HWE45_RS03965	ENOG4105C2J	ABC transporter
HWE45_RS03985	ENOG4108R85	Short chain dehydrogenase
HWE45_RS03990	ENOG4108RTU	Aldolase
HWE45_RS03995	ENOG4105CXK	mandelate racemase muconate lactonizing
HWE45_RS04005	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
HWE45_RS04010	ENOG4105G2Y	Transcriptional regulator
HWE45_RS04015	ENOG41090R7	Ferric uptake
HWE45_RS04020	ENOG4105YRI	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)
HWE45_RS04025	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
HWE45_RS04030	ENOG4105C8T	Leucyl-tRNA synthetase
HWE45_RS04040	ENOG4105DJF	DNA polymerase III, delta' subunit
HWE45_RS04045	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
HWE45_RS04050	ENOG4108YXA	Membrane
HWE45_RS04055	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
HWE45_RS04065	ENOG4105BZU	Histidine kinase
HWE45_RS04070	ENOG4105BZU	Histidine kinase
HWE45_RS04080	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
HWE45_RS04085	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HWE45_RS04090	ENOG4105W8H	transhydrogenase (subunit alpha
HWE45_RS04095	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
HWE45_RS04100	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HWE45_RS04115	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS04135	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
HWE45_RS04140	ENOG4105CBC	glutamate synthase
HWE45_RS04145	ENOG4108U78	Glutathione S-transferase
HWE45_RS04150	ENOG4107QTF	adenylosuccinate lyase
HWE45_RS04155	ENOG4105DS1	cytochrome b561
HWE45_RS04165	ENOG4108YYC	ycei family
HWE45_RS04170	ENOG4107RAB	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HWE45_RS04175	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
HWE45_RS04180	ENOG4105VIE	preprotein translocase, subunit YajC
HWE45_RS04185	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
HWE45_RS04190	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
HWE45_RS04195	ENOG4105CB5	ATP-dependent DNA helicase recG
HWE45_RS04220	ENOG4105C6T	cysteine synthase
HWE45_RS04230	ENOG4108XM1	transcriptional regulator AsnC family
HWE45_RS04235	ENOG4105CH2	amidohydrolase
HWE45_RS04240	ENOG41087PP	glycosyltransferase MGT family
HWE45_RS04255	ENOG4105F2I	Transposase
HWE45_RS04275	ENOG4105VEQ	Cold shock protein
HWE45_RS04345	ENOG4105C5Q	Transcriptional regulator
HWE45_RS04365	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
HWE45_RS04375	ENOG4105II7	pyrroline-5-carboxylate reductase
HWE45_RS04380	ENOG4105DFA	alanine racemase domain protein
HWE45_RS04385	ENOG4105CZX	twitching motility protein
HWE45_RS04390	ENOG4105CZX	twitching motility protein
HWE45_RS04445	ENOG41067MG	lrgb family
HWE45_RS04450	ENOG4105VAW	lrga family
HWE45_RS04455	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
HWE45_RS04460	ENOG4105EU8	FAD linked oxidase domain protein
HWE45_RS04465	ENOG4105CQB	FAD linked oxidase domain protein
HWE45_RS04475	ENOG4105CQB	FAD linked oxidase domain protein
HWE45_RS04480	ENOG4108WBT	adenosyltransferase
HWE45_RS04485	ENOG4105D64	Mechanosensitive ion channel
HWE45_RS04495	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HWE45_RS04500	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
HWE45_RS04515	ENOG4105CE6	Adenylation and deadenylation of glutamate--ammonia ligase (By similarity)
HWE45_RS04525	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HWE45_RS04530	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HWE45_RS04540	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
HWE45_RS04545	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
HWE45_RS04550	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
HWE45_RS04555	ENOG4105CZE	histidine utilization repressor
HWE45_RS04560	ENOG4105CGP	Urocanate hydratase
HWE45_RS04565	ENOG4105C84	Histidine ammonia-lyase
HWE45_RS04570	ENOG41088SP	formiminoglutamate hydrolase
HWE45_RS04575	ENOG4105CI2	imidazolone-5-propionate hydrolase
HWE45_RS04580	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
HWE45_RS04585	ENOG4105VEJ	Heat shock protein
HWE45_RS04595	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWE45_RS04605	ENOG4105NXH	GreA GreB family elongation factor
HWE45_RS04610	ENOG4105CFG	Acts as a chaperone (By similarity)
HWE45_RS04615	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
HWE45_RS04625	ENOG4108JJB	ABC transporter
HWE45_RS04630	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS04635	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
HWE45_RS04645	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWE45_RS04650	ENOG4105DJ0	Poly(A) Polymerase
HWE45_RS04660	ENOG4108KZ1	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity)
HWE45_RS04665	ENOG4105C02	permease
HWE45_RS04670	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
HWE45_RS04685	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HWE45_RS04695	ENOG4105CF1	Alkylated DNA repair protein
HWE45_RS04705	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
HWE45_RS04710	ENOG4108Z24	l-2,4-diaminobutyric acid acetyltransferase
HWE45_RS04715	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
HWE45_RS04720	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
HWE45_RS04725	ENOG4105DY2	Paraquat-inducible protein b
HWE45_RS04740	ENOG4105DQR	SNARE associated Golgi
HWE45_RS04750	ENOG4105CJR	Integral membrane protein (MviN
HWE45_RS04755	ENOG41082GY	Binds directly to 16S ribosomal RNA (By similarity)
HWE45_RS04765	ENOG4105DBV	ornithine carbamoyltransferase
HWE45_RS04770	ENOG4105CDH	Citrulline--aspartate ligase
HWE45_RS04775	ENOG4105NBK	UPF0345 protein
HWE45_RS04785	ENOG4105D4A	Cell wall formation (By similarity)
HWE45_RS04790	ENOG4108VPT	UPF0234 protein
HWE45_RS04795	ENOG4105DU0	nucleoside hydrolase
HWE45_RS04800	ENOG4107SQI	penicillin amidase
HWE45_RS04805	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
HWE45_RS04810	ENOG4108Z66	YbaK ebsC protein
HWE45_RS04815	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HWE45_RS04835	ENOG4105F2I	Transposase
HWE45_RS04840	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
HWE45_RS04845	ENOG4105K8N	protein family UPF0079, ATPase
HWE45_RS04850	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
HWE45_RS04855	ENOG4105DHU	Bile acid
HWE45_RS04860	ENOG4108M0I	Transcriptional regulator
HWE45_RS04865	ENOG4105C26	Dehydrogenase
HWE45_RS04870	ENOG4105JQN	Transcriptional regulator
HWE45_RS04880	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
HWE45_RS04885	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
HWE45_RS04890	ENOG4105W49	UPF0434 protein
HWE45_RS04895	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
HWE45_RS04910	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HWE45_RS04915	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HWE45_RS04935	ENOG41090B9	response to stress
HWE45_RS04955	ENOG4105CY2	Citrate transporter
HWE45_RS04980	ENOG4105E90	ABC transporter
HWE45_RS04985	ENOG4105CPI	Metal Dependent Phosphohydrolase
HWE45_RS05000	ENOG4105F87	Dehydratase
HWE45_RS05040	ENOG4105CYX	Short-chain dehydrogenase reductase Sdr
HWE45_RS05045	ENOG4105CGZ	zinc metallopeptidase
HWE45_RS05055	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
HWE45_RS05060	ENOG4108SB3	DoxX Family
HWE45_RS05065	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS05070	ENOG4105CR8	Transcriptional regulator
HWE45_RS05075	ENOG4105F04	LysR family Transcriptional regulator
HWE45_RS05080	ENOG41069B0	Membrane-bound lysozyme-inhibitor of c-type lysozyme
HWE45_RS05095	ENOG4105CA0	peroxidase
HWE45_RS05130	ENOG4105VEQ	Cold shock protein
HWE45_RS05135	ENOG4105KAE	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
HWE45_RS05140	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HWE45_RS05145	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
HWE45_RS05150	ENOG4105DEN	Luciferase family
HWE45_RS05155	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
HWE45_RS05165	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
HWE45_RS05170	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
HWE45_RS05175	ENOG4105DTN	riboflavin biosynthesis protein ribF
HWE45_RS05180	ENOG4105BZU	Histidine kinase
HWE45_RS05185	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS05190	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
HWE45_RS05205	ENOG4105EGS	Mechanosensitive ion channel
HWE45_RS05215	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
HWE45_RS05220	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
HWE45_RS05225	ENOG4108IYU	L-aspartate oxidase
HWE45_RS05230	ENOG4105W0E	50S ribosomal protein L33
HWE45_RS05235	ENOG4105KDC	50s ribosomal protein l28
HWE45_RS05240	ENOG4105W5Q	DNA repair protein (RadC
HWE45_RS05245	ENOG41090X3	Peptidyl-prolyl cis-trans isomerase
HWE45_RS05250	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
HWE45_RS05255	ENOG4105CP9	extracellular ligand-binding receptor
HWE45_RS05260	ENOG4105C32	Amino acid ABC transporter (Permease)
HWE45_RS05265	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HWE45_RS05270	ENOG4105C0Z	ABC transporter
HWE45_RS05275	ENOG4108IV0	ABC, transporter
HWE45_RS05285	ENOG4105C8Y	Acetylornithine aminotransferase
HWE45_RS05320	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HWE45_RS05330	ENOG4107R11	Transcriptional regulator
HWE45_RS05340	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
HWE45_RS05360	ENOG4105C3T	may be the GTPase, regulating ATP sulfurylase activity (By similarity)
HWE45_RS05365	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HWE45_RS05390	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
HWE45_RS05395	ENOG4105MYG	DNA polymerase iii, chi subunit
HWE45_RS05405	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS05410	ENOG4105C01	Dihydroxy-acid dehydratase
HWE45_RS05415	ENOG4106NZI	LysR family Transcriptional regulator
HWE45_RS05420	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
HWE45_RS05465	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS05470	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
HWE45_RS05475	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
HWE45_RS05485	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
HWE45_RS05490	ENOG4105EFT	decarboxylase
HWE45_RS05495	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HWE45_RS05500	ENOG4108YZT	Adenosylcobinamide kinase
HWE45_RS05505	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HWE45_RS05525	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
HWE45_RS05530	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
HWE45_RS05545	ENOG4105MA0	exported protein
HWE45_RS05555	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HWE45_RS05595	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
HWE45_RS05600	ENOG4105QAX	Iron-sulfur
HWE45_RS05620	ENOG4108Z7T	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
HWE45_RS05625	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HWE45_RS05630	ENOG4105DHP	deoxycytidine triphosphate deaminase
HWE45_RS05635	ENOG4105CXN	decarboxylase
HWE45_RS05680	ENOG4105CH7	arginosuccinase
HWE45_RS05705	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
HWE45_RS05710	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
HWE45_RS05715	ENOG41076E6	Uroporphyrinogen-III Synthase
HWE45_RS05735	ENOG4105CSP	Major Facilitator Superfamily
HWE45_RS05750	ENOG4105F0N	pyrophosphate phospho-hydrolase
HWE45_RS05765	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HWE45_RS05770	ENOG4108YZA	Nitrogen regulatory protein pii
HWE45_RS05775	ENOG4105EN6	Membrane
HWE45_RS05785	ENOG4105C3M	thioredoxin reductase
HWE45_RS05790	ENOG4105CNU	cell division protein FtsK
HWE45_RS05795	ENOG4107Y7W	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)
HWE45_RS05805	ENOG4105D1H	recombination factor protein RarA
HWE45_RS05810	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
HWE45_RS05820	ENOG4108C33	Resolvase
HWE45_RS05900	ENOG4108ZT1	Transcriptional regulator
HWE45_RS05910	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS05920	ENOG4105EWI	Short-chain dehydrogenase reductase Sdr
HWE45_RS05925	ENOG4108XM1	transcriptional regulator AsnC family
HWE45_RS05945	ENOG4105DXI	Major Facilitator superfamily
HWE45_RS05960	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS05970	ENOG4108VAU	general secretion pathway protein G
HWE45_RS05980	ENOG4107QHF	type ii secretion system protein e
HWE45_RS06015	ENOG4108VAU	general secretion pathway protein G
HWE45_RS06085	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWE45_RS06115	ENOG4105F2I	Transposase
HWE45_RS06145	ENOG4105C37	(CBS) domain
HWE45_RS06200	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HWE45_RS06205	ENOG4107RP9	extracellular solute-binding protein, family 3
HWE45_RS06215	ENOG4105DRP	amino acid AbC transporter
HWE45_RS06220	ENOG4105EAD	ABC transporter
HWE45_RS06225	ENOG4106PMH	Extracellular solute-binding protein family 3
HWE45_RS06235	ENOG4107HP6	Transcriptional regulator
HWE45_RS06245	ENOG4107QNJ	CoA-transferase subunit B
HWE45_RS06255	ENOG4107RAW	3-carboxy-cis-cis-muconate cycloisomerase
HWE45_RS06260	ENOG4105F2Z	3-oxoadipate enol-lactonase
HWE45_RS06265	ENOG4108UWZ	4-Carboxymuconolactone decarboxylase
HWE45_RS06280	ENOG4105C0Z	ABC transporter
HWE45_RS06285	ENOG4108IV0	ABC, transporter
HWE45_RS06290	ENOG4105CAD	extracellular ligand-binding receptor
HWE45_RS06305	ENOG4105GSQ	TM1410 hypothetical-related protein
HWE45_RS06315	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
HWE45_RS06330	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HWE45_RS06335	ENOG4105C4R	Atp-dependent dna helicase
HWE45_RS06345	ENOG4105CUV	Homoserine Kinase
HWE45_RS06355	ENOG4108URH	decarboxylase
HWE45_RS06360	ENOG4105C2M	dna polymerase I
HWE45_RS06365	ENOG4105CEP	NADH dehydrogenase
HWE45_RS06370	ENOG4105CDZ	Carboxymethylenebutenolidase (EC 3.1.1.45)
HWE45_RS06380	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS06385	ENOG4105KHC	sulfurtransferase
HWE45_RS06400	ENOG41082UU	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
HWE45_RS06405	ENOG4105CTB	Polyprenyl synthetase
HWE45_RS06410	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
HWE45_RS06415	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
HWE45_RS06420	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HWE45_RS06425	ENOG4105CBX	hi0933 family
HWE45_RS06430	ENOG4105KTH	gatB Yqey
HWE45_RS06440	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS06450	ENOG4105C8F	Beta-lactamase domain protein
HWE45_RS06465	ENOG4105C1J	atp-dependent rna helicase
HWE45_RS06470	ENOG4106F3G	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity)
HWE45_RS06475	ENOG4105EQ1	Transcriptional regulator
HWE45_RS06490	ENOG4105C72	UPF0176 protein
HWE45_RS06510	ENOG4106WTF	Glycosyl transferase, family 2
HWE45_RS06520	ENOG4105BZ1	(ABC) transporter
HWE45_RS06540	ENOG4105C03	ribonuclease
HWE45_RS06545	ENOG4108Z03	MAF-like protein
HWE45_RS06550	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
HWE45_RS06555	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
HWE45_RS06565	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
HWE45_RS06570	ENOG4105C12	Phosphoribosylglycinamide synthetase
HWE45_RS06575	ENOG4105CDY	transcriptional regulatory protein
HWE45_RS06580	ENOG4105D7A	ATP-binding protein
HWE45_RS06585	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
HWE45_RS06590	ENOG4106UX7	integral membrane protein
HWE45_RS06595	ENOG4105CHR	reductase
HWE45_RS06600	ENOG4108Z5K	methylglyoxal synthase
HWE45_RS06605	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
HWE45_RS06650	ENOG4105UIB	(ABC) transporter
HWE45_RS06655	ENOG4105C2J	ABC transporter
HWE45_RS06660	ENOG4105C2C	drug resistance transporter, Bcr CflA
HWE45_RS06665	ENOG4105P4J	Allophanate hydrolase, subunit 1
HWE45_RS06670	ENOG4107R7A	Allophanate hydrolase subunit 2
HWE45_RS06675	ENOG4105E7W	lamb ycsf family protein
HWE45_RS06690	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
HWE45_RS06695	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
HWE45_RS06710	ENOG4107UV6	ribonuclease Z
HWE45_RS06720	ENOG4105CSA	Coproporphyrinogen iii oxidase
HWE45_RS06725	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
HWE45_RS06730	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
HWE45_RS06745	ENOG4105DSJ	YicC domain protein
HWE45_RS06750	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
HWE45_RS06755	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
HWE45_RS06760	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HWE45_RS06770	ENOG4108RRZ	Transcription elongation factor GreB
HWE45_RS06790	ENOG4109066	lysm domain bon superfamily protein
HWE45_RS06795	ENOG4105CHR	reductase
HWE45_RS06800	ENOG4107UEK	pfkb domain protein
HWE45_RS06805	ENOG4105C6Q	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
HWE45_RS06825	ENOG4107UW8	HAD-superfamily hydrolase subfamily IA variant 3
HWE45_RS06830	ENOG4108IJ9	(ABC) transporter
HWE45_RS06840	ENOG4105KVH	Transcriptional regulator
HWE45_RS06845	ENOG4107QP8	phosphohexose isomerase
HWE45_RS06845	ENOG4107QP8	phosphohexose isomerase
HWE45_RS06850	ENOG4108Z9W	Outer membrane porin
HWE45_RS06875	ENOG4105DEI	Mannitol dehydrogenase
HWE45_RS06880	ENOG4105CMG	Carbohydrate kinase
HWE45_RS06885	ENOG4105DKT	Transcriptional regulator
HWE45_RS06895	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HWE45_RS06900	ENOG4105CD8	aminopeptidase N
HWE45_RS06910	ENOG4105C6K	Malic enzyme
HWE45_RS06920	ENOG4105FFA	Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity)
HWE45_RS06930	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HWE45_RS06935	ENOG4105C2W	permease
HWE45_RS06945	ENOG4105VT2	5-hydroxyisourate hydrolase
HWE45_RS06965	ENOG4105F2I	Transposase
HWE45_RS06970	ENOG4105CJP	fad dependent oxidoreductase
HWE45_RS06975	ENOG4105C54	Major Facilitator superfamily
HWE45_RS06980	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HWE45_RS06985	ENOG4105C26	Dehydrogenase
HWE45_RS06995	ENOG4108Z9W	Outer membrane porin
HWE45_RS07005	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS07010	ENOG4105E5Q	amino acid AbC transporter
HWE45_RS07015	ENOG4105E5Q	amino acid AbC transporter
HWE45_RS07025	ENOG4105JXH	GntR family transcriptional regulator
HWE45_RS07040	ENOG4107QUY	Guanine deaminase
HWE45_RS07045	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
HWE45_RS07055	ENOG4105CE2	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding
HWE45_RS07080	ENOG4105CV6	ABC transporter, permease
HWE45_RS07100	ENOG4108URH	decarboxylase
HWE45_RS07105	ENOG4107Z3H	Transcriptional regulator, TetR family
HWE45_RS07110	ENOG41080IJ	Diacylglycerol kinase
HWE45_RS07115	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
HWE45_RS07150	ENOG4105C7K	acetolactate synthase
HWE45_RS07155	ENOG4108ZP8	Acetolactate synthase small subunit
HWE45_RS07160	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
HWE45_RS07165	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
HWE45_RS07170	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
HWE45_RS07175	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
HWE45_RS07185	ENOG4105ES9	amino acid
HWE45_RS07190	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
HWE45_RS07195	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
HWE45_RS07200	ENOG4106TCE	
HWE45_RS07210	ENOG4105CP7	Triose-phosphate isomerase
HWE45_RS07215	ENOG4105NTZ	Preprotein translocase subunit SecG
HWE45_RS07225	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWE45_RS07230	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWE45_RS07235	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HWE45_RS07240	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWE45_RS07250	ENOG4107QIZ	NADH dehydrogenase
HWE45_RS07255	ENOG4108IEH	NADH dehydrogenase subunit g
HWE45_RS07260	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
HWE45_RS07265	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWE45_RS07270	ENOG4105DF2	NADH dehydrogenase subunit j
HWE45_RS07275	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWE45_RS07285	ENOG4105C8S	subunit m
HWE45_RS07290	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
HWE45_RS07310	ENOG4105CC9	acyl-Coa dehydrogenase
HWE45_RS07315	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS07320	ENOG4105DXM	phenylacetic acid degradation protein
HWE45_RS07335	ENOG4105C32	Amino acid ABC transporter (Permease)
HWE45_RS07345	ENOG4105C0Z	ABC transporter
HWE45_RS07350	ENOG4108IV0	ABC, transporter
HWE45_RS07355	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HWE45_RS07360	ENOG4108YZ9	Urea amidohydrolase subunit gamma
HWE45_RS07370	ENOG4105KI2	Urea amidohydrolase subunit beta
HWE45_RS07375	ENOG4105CQM	Urea amidohydrolase subunit alpha
HWE45_RS07380	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
HWE45_RS07385	ENOG4108WKG	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
HWE45_RS07390	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
HWE45_RS07415	ENOG4105CYM	Glutathione S-transferase
HWE45_RS07420	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS07450	ENOG4108UKI	Enoyl-CoA hydratase
HWE45_RS07455	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HWE45_RS07460	ENOG4105IU3	Glutathione S-transferase
HWE45_RS07465	ENOG4105CHM	Aminotransferase
HWE45_RS07475	ENOG4105D1Q	UPF0246 protein
HWE45_RS07490	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWE45_RS07505	ENOG4107QM5	aconitate hydratase
HWE45_RS07510	ENOG4105DXD	2-methylcitrate dehydratase
HWE45_RS07520	ENOG4105CR4	methylisocitrate lyase
HWE45_RS07530	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
HWE45_RS07535	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HWE45_RS07545	ENOG4105N1I	succinate dehydrogenase, hydrophobic membrane anchor protein
HWE45_RS07550	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
HWE45_RS07555	ENOG4105E33	succinate dehydrogenase
HWE45_RS07560	ENOG41060IS	Flavinator of succinate dehydrogenase
HWE45_RS07565	ENOG4105BZN	citrate synthase
HWE45_RS07570	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HWE45_RS07575	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
HWE45_RS07580	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HWE45_RS07590	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
HWE45_RS07600	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
HWE45_RS07605	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
HWE45_RS07610	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
HWE45_RS07620	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
HWE45_RS07625	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
HWE45_RS07630	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
HWE45_RS07645	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
HWE45_RS07650	ENOG4105HAC	ABC-2 type transporter
HWE45_RS07655	ENOG4105CJ1	ABC, transporter
HWE45_RS07685	ENOG4108ZJF	Glcg protein
HWE45_RS07695	ENOG4105SG9	biopolymer transport protein, ExbD
HWE45_RS07730	ENOG4105CK2	sodium dicarboxylate symporter
HWE45_RS07735	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
HWE45_RS07745	ENOG4108TEB	UPF0114 protein
HWE45_RS07750	ENOG4108PCN	EamA-like transporter family
HWE45_RS07755	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HWE45_RS07760	ENOG4107QN1	sodium solute
HWE45_RS07775	ENOG4105VJY	transcriptional regulator
HWE45_RS07780	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS07820	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWE45_RS07825	ENOG4108JQ7	(ABC) transporter
HWE45_RS07830	ENOG4105C3U	ABC transporter
HWE45_RS07840	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS07845	ENOG4105E1J	oxidoreductase
HWE45_RS07890	ENOG4107RZZ	dna polymerase iii epsilon subunit
HWE45_RS07930	ENOG4105CV8	reductase
HWE45_RS07950	ENOG4107YZX	Universal stress protein
HWE45_RS07985	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HWE45_RS07990	ENOG4105D1A	Methyltransferase
HWE45_RS07995	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HWE45_RS08000	ENOG4105E9H	Lytic Murein transglycosylase
HWE45_RS08005	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HWE45_RS08010	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
HWE45_RS08015	ENOG4108NIW	Leucine export protein LeuE
HWE45_RS08020	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
HWE45_RS08025	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
HWE45_RS08035	ENOG4105HBR	Rna-binding protein
HWE45_RS08040	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
HWE45_RS08045	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
HWE45_RS08050	ENOG4105EEI	dihydropteroate synthase
HWE45_RS08055	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
HWE45_RS08060	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
HWE45_RS08065	ENOG4105C8U	phosphate abc transporter
HWE45_RS08070	ENOG4105E2Z	phosphate ABC transporter (Permease
HWE45_RS08075	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS08085	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWE45_RS08090	ENOG4105BZU	Histidine kinase
HWE45_RS08095	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
HWE45_RS08100	ENOG4105C9X	ppx gppa phosphatase
HWE45_RS08125	ENOG4108VCT	Sulfite exporter TauE/SafE
HWE45_RS08135	ENOG41080HT	Transcriptional regulator, arsr family
HWE45_RS08145	ENOG4105BZU	Histidine kinase
HWE45_RS08200	ENOG4105CQB	FAD linked oxidase domain protein
HWE45_RS08210	ENOG4105CS1	NAD(P)H quinone oxidoreductase
HWE45_RS08215	ENOG4107S2Z	UPF0761 membrane protein
HWE45_RS08240	ENOG4107S74	Lysophospholipid transporter LplT
HWE45_RS08245	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HWE45_RS08250	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
HWE45_RS08255	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HWE45_RS08260	ENOG4105CHR	reductase
HWE45_RS08265	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HWE45_RS08280	ENOG4105DTD	Dehydrogenase
HWE45_RS08290	ENOG4105M4H	endoribonuclease L-psp
HWE45_RS08295	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
HWE45_RS08305	ENOG4105C22	threonyL-tRNA synthetase
HWE45_RS08310	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
HWE45_RS08315	ENOG4105VJV	50s ribosomal protein L35
HWE45_RS08320	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
HWE45_RS08325	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
HWE45_RS08330	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
HWE45_RS08335	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HWE45_RS08365	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
HWE45_RS08370	ENOG4105CUB	amino acid
HWE45_RS08390	ENOG4108V8F	Transcriptional regulator, MarR family
HWE45_RS08400	ENOG4105DZC	cytosine deaminase
HWE45_RS08405	ENOG4105DGW	oligopeptidase A
HWE45_RS08410	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
HWE45_RS08415	ENOG4108ZXC	Two component transcriptional regulator, luxr family
HWE45_RS08420	ENOG4105BZU	Histidine kinase
HWE45_RS08430	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
HWE45_RS08435	ENOG4107QSN	dihydrolipoamide acetyltransferase
HWE45_RS08445	ENOG4107QN2	dihydrolipoyl dehydrogenase
HWE45_RS08455	ENOG4108WFY	phasin family
HWE45_RS08460	ENOG4105DGU	Histone deacetylase
HWE45_RS08480	ENOG41061WM	D-Alanyl-D-Alanine
HWE45_RS08485	ENOG41069M3	Transcriptional regulator
HWE45_RS08495	ENOG4107QR9	Iron-sulfur cluster binding protein
HWE45_RS08515	ENOG4105DWA	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate
HWE45_RS08520	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
HWE45_RS08540	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
HWE45_RS08550	ENOG4105DFH	Transport of potassium into the cell (By similarity)
HWE45_RS08560	ENOG4105BZM	domain protein
HWE45_RS08575	ENOG4105DVT	helicase
HWE45_RS08585	ENOG4105C34	Pseudouridine synthase
HWE45_RS08590	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
HWE45_RS08600	ENOG4105D1N	poly(r)-hydroxyalkanoic acid synthase, class
HWE45_RS08605	ENOG4105CHU	acetyl-coa acetyltransferase
HWE45_RS08610	ENOG4105CHR	reductase
HWE45_RS08620	ENOG4105FBT	Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity)
HWE45_RS08625	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
HWE45_RS08630	ENOG4105CHU	acetyl-coa acetyltransferase
HWE45_RS08645	ENOG4105EAC	phosphoserine phosphatase
HWE45_RS08650	ENOG4105CWC	Acetylornithine deacetylase
HWE45_RS08655	ENOG4108JA2	transcriptioN-repair coupling factor
HWE45_RS08660	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
HWE45_RS08665	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
HWE45_RS08670	ENOG4108X7C	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)
HWE45_RS08675	ENOG4105D3R	alkyl hydroperoxide reductase
HWE45_RS08680	ENOG4105E0F	Histidine kinase
HWE45_RS08710	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HWE45_RS08730	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HWE45_RS08735	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
HWE45_RS08740	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
HWE45_RS08745	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
HWE45_RS08750	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
HWE45_RS08755	ENOG4105K70	DNA-binding protein
HWE45_RS08770	ENOG4107TF3	peptidylprolyl cis-trans isomerase
HWE45_RS08775	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS08780	ENOG4105C3F	Signal peptidase i
HWE45_RS08785	ENOG4108UJV	acyl-CoA thioesterase i
HWE45_RS08790	ENOG4108I0Y	(ABC) transporter
HWE45_RS08795	ENOG4107QP8	phosphohexose isomerase
HWE45_RS08800	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
HWE45_RS08810	ENOG4108ETH	Formylglycinamide ribotide synthetase
HWE45_RS08835	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
HWE45_RS08855	ENOG4105CBN	LysR family transcriptional regulator
HWE45_RS08860	ENOG4105CHR	reductase
HWE45_RS08870	ENOG4105F38	ABC transporter, permease
HWE45_RS08880	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS08885	ENOG4105DHQ	Histidine kinase
HWE45_RS08895	ENOG4108Z9W	Outer membrane porin
HWE45_RS08900	ENOG4105D5T	phosphonate abc transporter
HWE45_RS08925	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS08930	ENOG4107TF3	peptidylprolyl cis-trans isomerase
HWE45_RS08940	ENOG4107835	probably involved in intracellular septation (By similarity)
HWE45_RS08945	ENOG4105E0X	reductase
HWE45_RS08950	ENOG4105CNG	UPF0061 protein
HWE45_RS08955	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS08965	ENOG4105C32	Amino acid ABC transporter (Permease)
HWE45_RS08975	ENOG4105C0Z	ABC transporter
HWE45_RS08980	ENOG4108IV0	ABC, transporter
HWE45_RS08995	ENOG4108IQI	permease
HWE45_RS09000	ENOG4108IQI	permease
HWE45_RS09010	ENOG4108RWI	nicotinamidase
HWE45_RS09015	ENOG4105CHU	acetyl-coa acetyltransferase
HWE45_RS09020	ENOG4105CSU	acyl-Coa dehydrogenase
HWE45_RS09025	ENOG4105CHR	reductase
HWE45_RS09040	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
HWE45_RS09095	ENOG4105D5K	Hemolysin activator protein
HWE45_RS09110	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
HWE45_RS09115	ENOG4105HHA	aminodeoxychorismate lyase
HWE45_RS09120	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
HWE45_RS09125	ENOG4107QRG	dna polymerase iii
HWE45_RS09135	ENOG4105F8V	Hydrolase, tatD family
HWE45_RS09150	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS09155	ENOG4107QKW	extracellular solute-binding protein family 1
HWE45_RS09165	ENOG4105ECW	sulfate abc transporter
HWE45_RS09170	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS09175	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HWE45_RS09180	ENOG4108VBV	N-Acetylmuramoyl-L-alanine amidase
HWE45_RS09195	ENOG4107QSN	dihydrolipoamide acetyltransferase
HWE45_RS09215	ENOG4107R4J	Chloride channel
HWE45_RS09220	ENOG4108YRB	methyltransferase
HWE45_RS09230	ENOG4105C0W	non-ribosomal peptide synthetase
HWE45_RS09235	ENOG4107ZSV	Receptor
HWE45_RS09255	ENOG4105C0W	non-ribosomal peptide synthetase
HWE45_RS09275	ENOG4105KD7	acetyltransferase
HWE45_RS09315	ENOG4105ERH	Fumarylacetoacetate hydrolase
HWE45_RS09360	ENOG4106IPI	cyclase, family
HWE45_RS09375	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HWE45_RS09385	ENOG4105C87	Aminotransferase class I and II
HWE45_RS09490	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS09495	ENOG4105CW7	secretion protein, HlyD family
HWE45_RS09515	ENOG4107SQD	Transcriptional regulator, GntR family
HWE45_RS09525	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HWE45_RS09530	ENOG4105CCU	oxidase (Subunit III)
HWE45_RS09570	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
HWE45_RS09575	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HWE45_RS09610	ENOG4108RH0	Crea protein
HWE45_RS09650	ENOG4105XRQ	Xanthine dehydrogenase accessory factor
HWE45_RS09665	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS09675	ENOG4105BZP	glycoside hydrolase 15-related
HWE45_RS09700	ENOG4105C5H	ABC transporter
HWE45_RS09705	ENOG4105EBE	Peptidase U61, LD-carboxypeptidase A
HWE45_RS09710	ENOG4108Z6B	deaminase
HWE45_RS09735	ENOG4105CAF	HipA N-terminal domain protein
HWE45_RS09755	ENOG4105RM9	Protocatechuate 3,4-dioxygenase alpha
HWE45_RS09760	ENOG4105EU7	Protocatechuate 3,4-dioxygenase, beta
HWE45_RS09765	ENOG4105DDW	LysR family Transcriptional regulator
HWE45_RS09810	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HWE45_RS09820	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
HWE45_RS09825	ENOG4105DXC	membrane
HWE45_RS09840	ENOG4108Z1B	Cyclase dehydrase
HWE45_RS09845	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
HWE45_RS09850	ENOG4107QX8	SPFH domain, Band 7 family protein
HWE45_RS09860	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
HWE45_RS09865	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
HWE45_RS09875	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
HWE45_RS09880	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWE45_RS09885	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWE45_RS09890	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HWE45_RS09895	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
HWE45_RS09900	ENOG4105X4K	outer membrane chaperone skp
HWE45_RS09905	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWE45_RS09910	ENOG4105DZP	Membrane-associated zinc metalloprotease
HWE45_RS09915	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
HWE45_RS09920	ENOG4105KNE	Phosphatidate cytidylyltransferase
HWE45_RS09925	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
HWE45_RS09930	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
HWE45_RS09935	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
HWE45_RS09940	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
HWE45_RS09945	ENOG4105CE9	30S ribosomal protein S2
HWE45_RS09950	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
HWE45_RS09955	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
HWE45_RS09960	ENOG4105FE9	pseudouridine synthase
HWE45_RS09970	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HWE45_RS09975	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
HWE45_RS09990	ENOG4105CPT	Alpha beta hydrolase
HWE45_RS10005	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
HWE45_RS10015	ENOG4105KUZ	arsenate reductase
HWE45_RS10020	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HWE45_RS10030	ENOG4105C76	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity)
HWE45_RS10035	ENOG4105EUJ	GTP cyclohydrolase i
HWE45_RS10060	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS10065	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS10070	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWE45_RS10075	ENOG4108JQ6	ABC transporter
HWE45_RS10080	ENOG4105D44	asparaginase
HWE45_RS10090	ENOG4105C5H	ABC transporter
HWE45_RS10100	ENOG4105EWC	Purine nucleoside phosphorylase
HWE45_RS10105	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HWE45_RS10110	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
HWE45_RS10115	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
HWE45_RS10120	ENOG4108J8Q	Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity)
HWE45_RS10125	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
HWE45_RS10135	ENOG41072GX	Peptidase M22 Glycoprotease
HWE45_RS10155	ENOG4107QP3	malate synthase g
HWE45_RS10165	ENOG4105EJC	lysr family transcriptional regulator
HWE45_RS10195	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
HWE45_RS10210	ENOG4108HRK	Histidine kinase
HWE45_RS10225	ENOG4107R11	Transcriptional regulator
HWE45_RS10230	ENOG4108IJ6	ABC transporter
HWE45_RS10235	ENOG4105ECW	sulfate abc transporter
HWE45_RS10240	ENOG4108I5D	sulfate abc transporter
HWE45_RS10260	ENOG4105E2Y	ABC, transporter
HWE45_RS10265	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS10270	ENOG4105D4R	Catalyzes the desulfonation of aliphatic sulfonates (By similarity)
HWE45_RS10275	ENOG4105GVF	(ABC) transporter
HWE45_RS10285	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
HWE45_RS10290	ENOG4105D0C	transport protein
HWE45_RS10295	ENOG4107R1I	NAD-dependent malic enzyme
HWE45_RS10305	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS10320	ENOG4108IYU	L-aspartate oxidase
HWE45_RS10330	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HWE45_RS10335	ENOG4106BE1	Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity)
HWE45_RS10340	ENOG4107Z6W	Protein CrcB homolog
HWE45_RS10345	ENOG4108ZAF	Molybdopterin
HWE45_RS10350	ENOG4105M00	molybdopterin converting factor, subunit 1
HWE45_RS10355	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HWE45_RS10360	ENOG4108RG0	uracil-dna glycosylase
HWE45_RS10370	ENOG4105D6E	homoserine dehydrogenase
HWE45_RS10375	ENOG4105CHM	Aminotransferase
HWE45_RS10385	ENOG4105SA9	Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HWE45_RS10395	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HWE45_RS10410	ENOG4108JU4	Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity)
HWE45_RS10420	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWE45_RS10425	ENOG4108IAB	Phoh family
HWE45_RS10435	ENOG4105K4H	Nlp p60 protein
HWE45_RS10440	ENOG4107QXV	Phosphate transporter
HWE45_RS10450	ENOG4105CDU	Replicative dna helicase
HWE45_RS10455	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
HWE45_RS10460	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
HWE45_RS10470	ENOG4108ZDX	Binds together with S18 to 16S ribosomal RNA (By similarity)
HWE45_RS10480	ENOG4105DP0	ferredoxin-NADP reductase
HWE45_RS10485	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
HWE45_RS10495	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HWE45_RS10515	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HWE45_RS10520	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS10530	ENOG4105CI3	gtp-binding protein typa
HWE45_RS10545	ENOG4105CW7	secretion protein, HlyD family
HWE45_RS10550	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS10555	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
HWE45_RS10560	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
HWE45_RS10565	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
HWE45_RS10570	ENOG4105CHV	Transcription elongation factor NusA
HWE45_RS10575	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
HWE45_RS10580	ENOG4105FE9	pseudouridine synthase
HWE45_RS10585	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
HWE45_RS10595	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HWE45_RS10630	ENOG4105EUH	cytochrome C oxidase, cbb3-type, subunit i
HWE45_RS10640	ENOG4105C59	p-type ATPase
HWE45_RS10650	ENOG4105D6Z	AFG1 family ATPase
HWE45_RS10655	ENOG4107QN2	dihydrolipoyl dehydrogenase
HWE45_RS10660	ENOG4105C7S	Dehydrogenase
HWE45_RS10665	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HWE45_RS10670	ENOG4107T6V	glycerophosphoryl diester phosphodiesterase
HWE45_RS10675	ENOG4108IJ9	(ABC) transporter
HWE45_RS10690	ENOG4105BZ7	extracellular solute-binding protein family 1
HWE45_RS10705	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS10710	ENOG4105CUX	Signal transduction histidine kinase
HWE45_RS10730	ENOG4105CEV	competence damage-inducible protein
HWE45_RS10755	ENOG4105CQ7	ATP-dependent helicase
HWE45_RS10760	ENOG4108EKC	n-acetylglutamate synthase
HWE45_RS10765	ENOG4105NYY	transcriptional regulator, RpiR
HWE45_RS10770	ENOG4105CIB	oxidoreductase Domain protein
HWE45_RS10780	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
HWE45_RS10790	ENOG4105F0H	myo-inositol catabolism protein
HWE45_RS10795	ENOG4105CNN	ABC, transporter
HWE45_RS10800	ENOG4105C2J	ABC transporter
HWE45_RS10810	ENOG4105D7K	pfkb domain protein
HWE45_RS10815	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
HWE45_RS10835	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
HWE45_RS10840	ENOG4108NVR	Methyl-accepting chemotaxis
HWE45_RS10845	ENOG4105EW8	cytosine purines, uracil, thiamine, allantoin permease
HWE45_RS10850	ENOG4105E66	phosphoriboisomerase A
HWE45_RS10855	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
HWE45_RS10860	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
HWE45_RS10865	ENOG4105C2N	RNA methyltransferase TrmH family group 3
HWE45_RS10870	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
HWE45_RS10880	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
HWE45_RS10885	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
HWE45_RS10890	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
HWE45_RS10900	ENOG4105EPW	hflc protein
HWE45_RS10905	ENOG4107QJR	hflk protein
HWE45_RS10910	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
HWE45_RS10915	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
HWE45_RS10920	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
HWE45_RS10930	ENOG4105N21	Membrane
HWE45_RS10935	ENOG4105CUT	histidyl-tRNA synthetase
HWE45_RS10940	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
HWE45_RS10955	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
HWE45_RS10960	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
HWE45_RS10970	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
HWE45_RS10980	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS10985	ENOG4108K5P	(LipO)protein
HWE45_RS10990	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HWE45_RS10995	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
HWE45_RS11005	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HWE45_RS11010	ENOG4108WUH	Transcriptional regulator, TetR family
HWE45_RS11015	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS11025	ENOG4105D2X	ABC transporter substrate-binding protein
HWE45_RS11030	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HWE45_RS11045	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
HWE45_RS11050	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
HWE45_RS11055	ENOG4107QMP	dna polymerase iii subunits gamma and tau
HWE45_RS11065	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
HWE45_RS11075	ENOG4105K63	Thioredoxin
HWE45_RS11080	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
HWE45_RS11085	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS11105	ENOG4105NRA	50s ribosomal protein l31 type b
HWE45_RS11115	ENOG4107QI1	Mate efflux family protein
HWE45_RS11150	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
HWE45_RS11155	ENOG4105D78	K07001 NTE family protein
HWE45_RS11160	ENOG4105K4H	Nlp p60 protein
HWE45_RS11165	ENOG4108JQ5	ABC transporter
HWE45_RS11170	ENOG4108IYQ	Binding-protein-dependent transport systems inner membrane component
HWE45_RS11175	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
HWE45_RS11185	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
HWE45_RS11195	ENOG4105CFH	Aspartokinase
HWE45_RS11200	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
HWE45_RS11205	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
HWE45_RS11215	ENOG4105C8N	cysteinyl-tRNA synthetase
HWE45_RS11230	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
HWE45_RS11235	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
HWE45_RS11240	ENOG4105D7W	serine acetyltransferase
HWE45_RS11250	ENOG4105ECY	inositol monophosphatase
HWE45_RS11260	ENOG41089BK	Glutamine amido-transferase
HWE45_RS11265	ENOG4108RPX	mosc domain containing protein
HWE45_RS11270	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS11275	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS11280	ENOG4105CV8	reductase
HWE45_RS11285	ENOG4105F27	Major Facilitator
HWE45_RS11290	ENOG4105HEI	LysR family (Transcriptional regulator
HWE45_RS11310	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
HWE45_RS11320	ENOG4108YZY	peptidylprolyl cis-trans isomerase
HWE45_RS11325	ENOG4105EZE	Cupin 4 family protein
HWE45_RS11335	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
HWE45_RS11340	ENOG4105GJM	(LipO)protein
HWE45_RS11345	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HWE45_RS11355	ENOG4105C31	Tryptophanyl-tRNA synthetase
HWE45_RS11360	ENOG4108Z4T	Peptidase M50
HWE45_RS11365	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
HWE45_RS11370	ENOG4105DB7	PHP domain protein
HWE45_RS11375	ENOG4105CAY	ferredoxin--nadp reductase
HWE45_RS11390	ENOG4105KIR	Thiol-disulfide oxidoreductase dcc
HWE45_RS11395	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HWE45_RS11400	ENOG4105ED9	Protein of unknown function (DUF455)
HWE45_RS11405	ENOG4108Z0R	Transferase
HWE45_RS11410	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
HWE45_RS11420	ENOG4105XX3	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)
HWE45_RS11425	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
HWE45_RS11435	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
HWE45_RS11440	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
HWE45_RS11445	ENOG4108MUZ	hydrolase
HWE45_RS11470	ENOG4108EC8	DNA internalization-related competence protein ComEC
HWE45_RS11475	ENOG4105EYA	deoxyribonuclease
HWE45_RS11480	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HWE45_RS11495	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
HWE45_RS11500	ENOG4108Z4U	Ferredoxin
HWE45_RS11570	ENOG4105EKQ	RNA-directed DNA polymerase
HWE45_RS11590	ENOG4105F2I	Transposase
HWE45_RS11600	ENOG4105CHR	reductase
HWE45_RS11615	ENOG4105EMU	Dehydrogenase
HWE45_RS11655	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
HWE45_RS11695	ENOG4105FA0	parb-like partition protein
HWE45_RS11730	ENOG4105F2I	Transposase
HWE45_RS11785	ENOG4105HMI	Membrane
HWE45_RS11790	ENOG4105DUM	transcriptional regulator, lysR family
HWE45_RS11830	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
HWE45_RS11855	ENOG4105ECQ	AraC Family Transcriptional Regulator
HWE45_RS11875	ENOG4108M0I	Transcriptional regulator
HWE45_RS11920	ENOG4108RXX	maleylacetoacetate isomerase
HWE45_RS11925	ENOG4108Z9W	Outer membrane porin
HWE45_RS11935	ENOG4108Z9W	Outer membrane porin
HWE45_RS11945	ENOG4105DPW	Major facilitator superfamily MFS_1
HWE45_RS11955	ENOG4108KWP	DNA-binding transcriptional regulator GlcC
HWE45_RS11960	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS11970	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HWE45_RS11975	ENOG4105BZU	Histidine kinase
HWE45_RS11985	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWE45_RS12010	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
HWE45_RS12020	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
HWE45_RS12030	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
HWE45_RS12035	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
HWE45_RS12040	ENOG41071DT	Involved in DNA repair and RecF pathway recombination (By similarity)
HWE45_RS12045	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
HWE45_RS12050	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
HWE45_RS12060	ENOG4105C3F	Signal peptidase i
HWE45_RS12065	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
HWE45_RS12075	ENOG4105C0H	protease
HWE45_RS12090	ENOG4105EMN	RNA polymerase sigma factor
HWE45_RS12100	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWE45_RS12105	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
HWE45_RS12110	ENOG4105CHR	reductase
HWE45_RS12115	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
HWE45_RS12120	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
HWE45_RS12125	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
HWE45_RS12130	ENOG4105VGS	50s ribosomal protein l32
HWE45_RS12135	ENOG4105FCQ	metal-binding, possibly nucleic acid-binding protein
HWE45_RS12140	ENOG4108UHJ	MAF-like protein
HWE45_RS12145	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
HWE45_RS12150	ENOG4108E8C	) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
HWE45_RS12160	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HWE45_RS12165	ENOG4105EI2	Pseudouridine synthase
HWE45_RS12170	ENOG4105C03	ribonuclease
HWE45_RS12175	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HWE45_RS12180	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
HWE45_RS12185	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
HWE45_RS12195	ENOG4107QSV	RmuC domain protein
HWE45_RS12200	ENOG4105C5I	Dehydrogenase
HWE45_RS12210	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
HWE45_RS12215	ENOG4107RH7	Nicotinate phosphoribosyltransferase
HWE45_RS12225	ENOG410904N	short-chain dehydrogenase reductase
HWE45_RS12230	ENOG4105CRK	lysyL-tRNA synthetase
HWE45_RS12240	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS12245	ENOG4105WVQ	Fe-S assembly protein IscX
HWE45_RS12250	ENOG4108ZIT	Ferredoxin, 2FE-2S
HWE45_RS12255	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
HWE45_RS12260	ENOG4108SWN	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity)
HWE45_RS12270	ENOG4108Z4V	iron-sulfur cluster assembly
HWE45_RS12275	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
HWE45_RS12280	ENOG4105C3J	Cysteine desulfurase
HWE45_RS12290	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
HWE45_RS12300	ENOG4105CNN	ABC, transporter
HWE45_RS12305	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS12310	ENOG4108RVA	ribokinase
HWE45_RS12320	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
HWE45_RS12325	ENOG4105CGF	Aromatic amino acid aminotransferase
HWE45_RS12335	ENOG4108W9H	Tetr family transcriptional regulator
HWE45_RS12340	ENOG4108R3D	Electron transport complex
HWE45_RS12345	ENOG4105CSM	endonuclease III
HWE45_RS12350	ENOG4108RDT	NADH dehydrogenase NAD(P)H nitroreductase)
HWE45_RS12425	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
HWE45_RS12430	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HWE45_RS12435	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HWE45_RS12440	ENOG4105T38	integral membrane protein
HWE45_RS12450	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HWE45_RS12455	ENOG4108TGY	Glutathione S-transferase
HWE45_RS12470	ENOG4105DAA	L-lactate
HWE45_RS12485	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWE45_RS12490	ENOG4105E4C	Lytic transglycosylase catalytic
HWE45_RS12495	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWE45_RS12500	ENOG4105C5H	ABC transporter
HWE45_RS12510	ENOG4105F87	Dehydratase
HWE45_RS12540	ENOG4105C1J	atp-dependent rna helicase
HWE45_RS12545	ENOG4105E46	N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process
HWE45_RS12555	ENOG4108ZCF	integral membrane protein
HWE45_RS12565	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
HWE45_RS12575	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
HWE45_RS12580	ENOG4105N42	UPF0307 protein
HWE45_RS12585	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
HWE45_RS12590	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
HWE45_RS12595	ENOG4105D0M	Protease HtpX homolog
HWE45_RS12600	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
HWE45_RS12610	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
HWE45_RS12615	ENOG4105P8F	nudix hydrolase
HWE45_RS12620	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
HWE45_RS12625	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
HWE45_RS12630	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
HWE45_RS12635	ENOG4105K5M	30s ribosomal protein S16
HWE45_RS12640	ENOG4105DKB	L-sorbosone dehydrogenase
HWE45_RS12665	ENOG4105EW9	transcriptional regulator AsnC family
HWE45_RS12670	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HWE45_RS12675	ENOG4105CSU	acyl-Coa dehydrogenase
HWE45_RS12680	ENOG4105C10	Electron transfer flavoprotein
HWE45_RS12685	ENOG4105BZJ	Electron transfer flavoprotein
HWE45_RS12690	ENOG4105D01	(LipO)protein
HWE45_RS12695	ENOG4108UMI	ABC transporter, permease
HWE45_RS12700	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
HWE45_RS12710	ENOG4105CVE	Lytic murein transglycosylase
HWE45_RS12715	ENOG4105C6T	cysteine synthase
HWE45_RS12725	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
HWE45_RS12730	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HWE45_RS12735	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
HWE45_RS12740	ENOG4105CFV	Tetratricopeptide repeat protein
HWE45_RS12750	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
HWE45_RS12755	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
HWE45_RS12760	ENOG4105CAT	Cytidine monophosphate kinase
HWE45_RS12765	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
HWE45_RS12775	ENOG4105CIH	Imidazole acetol-phosphate transaminase
HWE45_RS12780	ENOG4105CQC	Prephenate dehydratase
HWE45_RS12785	ENOG4107QM1	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)
HWE45_RS12795	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
HWE45_RS12800	ENOG4105UYK	outer membrane protein a
HWE45_RS12810	ENOG4108HWB	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
HWE45_RS12815	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HWE45_RS12870	ENOG4105F2I	Transposase
HWE45_RS13000	ENOG4105D5K	Hemolysin activator protein
HWE45_RS13170	ENOG4105CS6	Rhs element vgr protein
HWE45_RS13175	ENOG4105ETT	transcriptional Regulator, LysR family
HWE45_RS13280	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS13400	ENOG4105CEC	DNA methylase N-4 N-6
HWE45_RS13625	ENOG4105F2I	Transposase
HWE45_RS13645	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HWE45_RS13675	ENOG4105EMU	Dehydrogenase
HWE45_RS13800	ENOG4108IG5	Transcriptional regulator
HWE45_RS13805	ENOG4105E1F	short-chain dehydrogenase reductase
HWE45_RS13810	ENOG4105CB2	alcohol dehydrogenase
HWE45_RS13830	ENOG4105F2I	Transposase
HWE45_RS13865	ENOG4108YQE	rare lipoprotein a
HWE45_RS13870	ENOG4108K3A	Glutathione S-transferase
HWE45_RS13885	ENOG4105N14	lysine exporter protein LysE YggA
HWE45_RS13900	ENOG41082K8	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity)
HWE45_RS13910	ENOG4105C5W	Aldolase
HWE45_RS13915	ENOG41084KP	4-oxalocrotonate tautomerase
HWE45_RS13920	ENOG4105MP9	class II Aldolase
HWE45_RS13925	ENOG4105CBP	Major Facilitator
HWE45_RS13930	ENOG4105EGI	Transcriptional regulator
HWE45_RS13965	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
HWE45_RS13970	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HWE45_RS13995	ENOG4105CX6	glutaminyL-tRNA synthetase
HWE45_RS14025	ENOG4108VWS	Yaeq family
HWE45_RS14030	ENOG4108V1T	peptidylprolyl cis-trans isomerase
HWE45_RS14040	ENOG4108NH8	Cation transport protein
HWE45_RS14050	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS14055	ENOG4105K63	Thioredoxin
HWE45_RS14065	ENOG4105Y3Q	hemerythrin-like, metal-binding protein
HWE45_RS14070	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
HWE45_RS14075	ENOG4105CUZ	uba thif-type nad fad binding protein
HWE45_RS14080	ENOG41066T0	asmA family
HWE45_RS14105	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
HWE45_RS14110	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HWE45_RS14120	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
HWE45_RS14135	ENOG4105F7P	transcriptional regulator AsnC family
HWE45_RS14140	ENOG4107VWA	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation (By similarity)
HWE45_RS14150	ENOG4105HJ8	Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring (By similarity)
HWE45_RS14160	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS14165	ENOG4105C7N	Xanthine uracil vitamin C permease
HWE45_RS14170	ENOG4105D3R	alkyl hydroperoxide reductase
HWE45_RS14175	ENOG4105TNS	Conserved Protein
HWE45_RS14195	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HWE45_RS14230	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
HWE45_RS14235	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HWE45_RS14240	ENOG4108VYJ	response regulator receiver protein
HWE45_RS14250	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS14260	ENOG4105CUC	YeeE YedE family protein
HWE45_RS14265	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
HWE45_RS14275	ENOG4105KCK	Peptidoglycan-associated lipoprotein
HWE45_RS14280	ENOG4107R6Y	Involved in the TonB-independent uptake of proteins (By similarity)
HWE45_RS14290	ENOG4105M8F	Biopolymer transport protein exbD tolR
HWE45_RS14295	ENOG4105E02	MotA TolQ exbB proton channel
HWE45_RS14300	ENOG4107YD3	Thioesterase
HWE45_RS14305	ENOG4105EMU	Dehydrogenase
HWE45_RS14310	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
HWE45_RS14315	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
HWE45_RS14380	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
HWE45_RS14390	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
HWE45_RS14395	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
HWE45_RS14400	ENOG4107YIM	Involved in the transcription termination process (By similarity)
HWE45_RS14410	ENOG4106S48	Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division
HWE45_RS14415	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
HWE45_RS14445	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
HWE45_RS14450	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HWE45_RS14455	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
HWE45_RS14465	ENOG4105KRS	Proteinase inhibitor
HWE45_RS14470	ENOG4108IG5	Transcriptional regulator
HWE45_RS14475	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
HWE45_RS14480	ENOG4105VFE	sira family
HWE45_RS14495	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
HWE45_RS14500	ENOG4105D16	lipopolysaccharide heptosyltransferase i
HWE45_RS14515	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
HWE45_RS14535	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
HWE45_RS14550	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
HWE45_RS14555	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
HWE45_RS14565	ENOG4105CD3	dihydroorotase
HWE45_RS14570	ENOG4105CXT	aspartate transcarbamylase
HWE45_RS14575	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
HWE45_RS14580	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
HWE45_RS14585	ENOG4108UJU	UPF0301 protein
HWE45_RS14590	ENOG4105I08	Pseudouridine synthase
HWE45_RS14605	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS14615	ENOG4105M3Z	response regulator
HWE45_RS14620	ENOG4108UNF	response regulator
HWE45_RS14625	ENOG4105VCQ	rubredoxin
HWE45_RS14630	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
HWE45_RS14635	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
HWE45_RS14640	ENOG4108V0P	LemA family
HWE45_RS14745	ENOG4108M3P	Membrane
HWE45_RS14750	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HWE45_RS14755	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
HWE45_RS14775	ENOG4105EQW	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
HWE45_RS14780	ENOG4108S1C	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HWE45_RS14785	ENOG4105DH7	May be involved in recombination (By similarity)
HWE45_RS14850	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS14855	ENOG4107QPD	alcohol dehydrogenase
HWE45_RS14875	ENOG4105F1S	paraquat-inducible protein a
HWE45_RS14880	ENOG4105DY2	Paraquat-inducible protein b
HWE45_RS14890	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HWE45_RS14925	ENOG4105CPI	Metal Dependent Phosphohydrolase
HWE45_RS14945	ENOG4105BZU	Histidine kinase
HWE45_RS14965	ENOG4107RVU	D-Ala-D-Ala carboxypeptidase 3 (S13) family
HWE45_RS14970	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
HWE45_RS14980	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
HWE45_RS14990	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
HWE45_RS14995	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
HWE45_RS15000	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
HWE45_RS15005	ENOG4105C8V	SAICAR synthetase
HWE45_RS15015	ENOG4105CA9	Pyruvate kinase
HWE45_RS15020	ENOG4105BZA	Phosphoglycerate kinase
HWE45_RS15025	ENOG4105FR1	rard protein
HWE45_RS15040	ENOG4105CM2	brancheD-chain amino acid aminotransferase
HWE45_RS15050	ENOG4105XA0	heptosyltransferase ii
HWE45_RS15060	ENOG4105DNZ	Alpha Beta Hydrolase
HWE45_RS15070	ENOG4105ERG	peptidase m48, ste24p
HWE45_RS15075	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
HWE45_RS15085	ENOG4105KHS	type IV fimbrial pilin protein
HWE45_RS15105	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
HWE45_RS15110	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
HWE45_RS15120	ENOG4108004	Modulates RecA activity (By similarity)
HWE45_RS15125	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
HWE45_RS15135	ENOG4105DHQ	Histidine kinase
HWE45_RS15145	ENOG4105CSH	Transporter
HWE45_RS15175	ENOG4105EXG	Transcriptional regulator
HWE45_RS15180	ENOG4105EUB	pirin domain protein
HWE45_RS15185	ENOG4105E27	serine threonine protein kinase
HWE45_RS15190	ENOG4105C1J	atp-dependent rna helicase
HWE45_RS15195	ENOG4105F2I	Transposase
HWE45_RS15205	ENOG4107QPN	acyl-Coa dehydrogenase
HWE45_RS15210	ENOG4105CHR	reductase
HWE45_RS15220	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS15255	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
HWE45_RS15260	ENOG4105C9A	Phoh family
HWE45_RS15265	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
HWE45_RS15270	ENOG4108JU5	Magnesium and cobalt efflux protein
HWE45_RS15275	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
HWE45_RS15280	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
HWE45_RS15290	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
HWE45_RS15295	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
HWE45_RS15300	ENOG4105E9Q	Acyl-transferase
HWE45_RS15310	ENOG4108UYE	Lactoylglutathione lyase
HWE45_RS15315	ENOG4108594	Permease of the drug metabolite transporter
HWE45_RS15320	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
HWE45_RS15325	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
HWE45_RS15330	ENOG4105DBD	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity)
HWE45_RS15335	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
HWE45_RS15340	ENOG4105EHM	Aminoglycoside phosphotransferase
HWE45_RS15355	ENOG4108S0S	Nucleotidyl transferase
HWE45_RS15360	ENOG4105BZU	Histidine kinase
HWE45_RS15365	ENOG4107RAQ	aminopeptidase
HWE45_RS15370	ENOG4105D0A	hydroxylase
HWE45_RS15375	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
HWE45_RS15380	ENOG4105R48	this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase
HWE45_RS15390	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
HWE45_RS15395	ENOG4105VY0	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)
HWE45_RS15400	ENOG4105DC1	bifunctional purine biosynthesis protein purh
HWE45_RS15405	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
HWE45_RS15415	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
HWE45_RS15420	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
HWE45_RS15435	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
HWE45_RS15440	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
HWE45_RS15445	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
HWE45_RS15450	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
HWE45_RS15465	ENOG4108UJD	30S ribosomal protein S9
HWE45_RS15470	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
HWE45_RS15490	ENOG4105EKE	dihydroorotase
HWE45_RS15500	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HWE45_RS15505	ENOG4105E7A	Glutamine amidotransferase
HWE45_RS15510	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS15515	ENOG4105DRP	amino acid AbC transporter
HWE45_RS15520	ENOG4105EAD	ABC transporter
HWE45_RS15525	ENOG4107RP9	extracellular solute-binding protein, family 3
HWE45_RS15530	ENOG4105D82	Glutamate dehydrogenase
HWE45_RS15540	ENOG4108JJ7	ABC transporter
HWE45_RS15545	ENOG4105NAU	thioesterase Superfamily protein
HWE45_RS15550	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS15555	ENOG4105CHU	acetyl-coa acetyltransferase
HWE45_RS15565	ENOG4105CSU	acyl-Coa dehydrogenase
HWE45_RS15575	ENOG4108IIG	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
HWE45_RS15580	ENOG4105DZQ	phospholipase D Transphosphatidylase
HWE45_RS15585	ENOG4105X23	Endonuclease Exonuclease phosphatase
HWE45_RS15590	ENOG4108TIT	dATP pyrophosphohydrolase
HWE45_RS15600	ENOG4105C9M	aspartyl-trna synthetase
HWE45_RS15625	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
HWE45_RS15640	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
HWE45_RS15665	ENOG4105W39	Membrane
HWE45_RS15685	ENOG4105C7B	Threonine dehydratase
HWE45_RS15690	ENOG4105CSD	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
HWE45_RS15720	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS15725	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HWE45_RS15740	ENOG4105MD1	YeeE YedE family protein
HWE45_RS15755	ENOG4105C2D	reductase
HWE45_RS15770	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
HWE45_RS15795	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWE45_RS15830	ENOG4108UUM	single-stranded DNA-binding protein
HWE45_RS15835	ENOG4107RDB	Major Facilitator
HWE45_RS15840	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HWE45_RS15850	ENOG410829K	Lysine exporter protein (Lyse ygga)
HWE45_RS15855	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
HWE45_RS15860	ENOG4107R7Y	intracellular protease Pfpi family
HWE45_RS15875	ENOG4105C2X	Arabinose 5-phosphate isomerase
HWE45_RS15880	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
HWE45_RS15895	ENOG4108IUZ	ABC transporter
HWE45_RS15900	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS15905	ENOG41080QH	sigma 54 modulation protein ribosomal protein S30EA
HWE45_RS15910	ENOG4107RM2	PTS IIA-like nitrogen-regulatory protein PtsN
HWE45_RS15915	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
HWE45_RS15925	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
HWE45_RS15935	ENOG4105CEN	a g-specific adenine glycosylase
HWE45_RS15945	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
HWE45_RS15955	ENOG4105QVB	outer membrane lipoprotein LolB
HWE45_RS15960	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
HWE45_RS15970	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HWE45_RS15975	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
HWE45_RS15980	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
HWE45_RS15990	ENOG4105K5D	4fe-4S ferredoxin iroN-sulfur binding
HWE45_RS15995	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
HWE45_RS16000	ENOG4106H78	methyltransferase
HWE45_RS16025	ENOG4108RXX	maleylacetoacetate isomerase
HWE45_RS16040	ENOG4105I5W	Transporter
HWE45_RS16050	ENOG4105D7T	ABC transporter
HWE45_RS16055	ENOG4108MTB	glycosyl transferase family
HWE45_RS16060	ENOG4105EUB	pirin domain protein
HWE45_RS16070	ENOG4105BZU	Histidine kinase
HWE45_RS16075	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS16080	ENOG4108ZX6	Electron transport protein SCO1 SenC
HWE45_RS16085	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
HWE45_RS16090	ENOG4107SGF	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)
HWE45_RS16110	ENOG4107QS1	Cytochrome C Oxidase, Subunit III
HWE45_RS16120	ENOG4105FT1	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I (By similarity)
HWE45_RS16125	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HWE45_RS16130	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HWE45_RS16140	ENOG4106T9E	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HWE45_RS16145	ENOG4105MJ2	Competence protein
HWE45_RS16155	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
HWE45_RS16160	ENOG4105IX2	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)
HWE45_RS16165	ENOG4105VW4	glutaredoxin 3
HWE45_RS16170	ENOG4107YZP	Rhodanese domain protein
HWE45_RS16175	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
HWE45_RS16180	ENOG4105CN1	protease
HWE45_RS16185	ENOG4105D06	uba thif-type nad fad binding protein
HWE45_RS16190	ENOG4108UQY	Iron-storage protein
HWE45_RS16200	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HWE45_RS16205	ENOG41080Z8	PHOSPHOCARRIER protein
HWE45_RS16215	ENOG4105D7Z	glutathione synthase
HWE45_RS16225	ENOG4105BZU	Histidine kinase
HWE45_RS16230	ENOG4108YZA	Nitrogen regulatory protein pii
HWE45_RS16240	ENOG4105W0Z	cytoplasmic protein
HWE45_RS16390	ENOG4108UVJ	appr-1-p processing domain protein
HWE45_RS16410	ENOG4105CK2	sodium dicarboxylate symporter
HWE45_RS16415	ENOG4105NZG	Ferredoxin
HWE45_RS16425	ENOG4105DZ1	carboxypeptidase
HWE45_RS16430	ENOG4108Z43	UPF0250 protein
HWE45_RS16435	ENOG4105ETT	transcriptional Regulator, LysR family
HWE45_RS16445	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
HWE45_RS16450	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
HWE45_RS16500	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
HWE45_RS16505	ENOG4108194	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
HWE45_RS16515	ENOG4107Z67	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
HWE45_RS16540	ENOG4105CGU	Enoyl-CoA hydratase
HWE45_RS16570	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
HWE45_RS16585	ENOG4105C3R	Methionine synthase
HWE45_RS16590	ENOG4105C3R	Methionine synthase
HWE45_RS16605	ENOG4108NEV	two component transcriptional regulator, LytTR family
HWE45_RS16630	ENOG4105C75	arginyL-tRNA synthetase
HWE45_RS16645	ENOG4105EMU	Dehydrogenase
HWE45_RS16655	ENOG4105F2I	Transposase
HWE45_RS16660	ENOG4105F2I	Transposase
HWE45_RS16680	ENOG4105F2I	Transposase
HWE45_RS16685	ENOG4105F2I	Transposase
HWE45_RS16695	ENOG4105F2I	Transposase
HWE45_RS16715	ENOG4105F2I	Transposase
HWE45_RS16720	ENOG4105JAB	phenazine biosynthesis protein, phzf family
HWE45_RS16735	ENOG4105EBM	Alpha Beta Hydrolase Fold protein
HWE45_RS16745	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
HWE45_RS16760	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
HWE45_RS16765	ENOG4105JPG	D-isomer specific 2-hydroxyacid dehydrogenase
HWE45_RS16785	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
HWE45_RS16790	ENOG4108IPT	Naphthoate synthase
HWE45_RS16800	ENOG4107QX3	carboxylase
HWE45_RS16805	ENOG4105K5B	UPF0225 protein
HWE45_RS16810	ENOG4107UB3	HAD-superfamily hydrolase subfamily IA variant 3
HWE45_RS16825	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS16830	ENOG4105CHR	reductase
HWE45_RS16835	ENOG4105CHU	acetyl-coa acetyltransferase
HWE45_RS16840	ENOG41077A9	carbonic anhydrase
HWE45_RS16845	ENOG4105VS7	Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)
HWE45_RS16850	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS16855	ENOG4108Z6Z	Transcriptional regulator
HWE45_RS16865	ENOG4105KAC	Antibiotic biosynthesis monooxygenase
HWE45_RS16895	ENOG4105F2I	Transposase
HWE45_RS16905	ENOG4105F2I	Transposase
HWE45_RS16910	ENOG4105F2I	Transposase
HWE45_RS16920	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
HWE45_RS16925	ENOG4105CBN	LysR family transcriptional regulator
HWE45_RS16955	ENOG4105D5P	Methylmalonyl-coA mutase
HWE45_RS16995	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
HWE45_RS17005	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
HWE45_RS17010	ENOG410756H	nucleotidyltransferase
HWE45_RS17015	ENOG4105E0Y	RtcB Protein
HWE45_RS17025	ENOG4105CYB	regulatoR
HWE45_RS17040	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
HWE45_RS17055	ENOG4105C2C	drug resistance transporter, Bcr CflA
HWE45_RS17060	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
HWE45_RS17065	ENOG4105EGI	Transcriptional regulator
HWE45_RS17070	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
HWE45_RS17085	ENOG4105KVH	Transcriptional regulator
HWE45_RS17115	ENOG4105ENX	hydrolase
HWE45_RS17120	ENOG4105EQ2	LysR family Transcriptional regulator
HWE45_RS17125	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
HWE45_RS17135	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
HWE45_RS17140	ENOG4105CY0	Metallo-Beta-Lactamase
HWE45_RS17145	ENOG4107Y70	Heat shock protein
HWE45_RS17155	ENOG4105CPW	cytochrome b561
HWE45_RS17165	ENOG4106RE7	Cytochrome
HWE45_RS17175	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
HWE45_RS17180	ENOG4105CPQ	Dehydrogenase
HWE45_RS17195	ENOG4105BZU	Histidine kinase
HWE45_RS17200	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
HWE45_RS17230	ENOG4107YZX	Universal stress protein
HWE45_RS17235	ENOG41080XQ	Signal transduction protein with cbs domains
HWE45_RS17255	ENOG4107YZX	Universal stress protein
HWE45_RS17260	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
HWE45_RS17265	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
HWE45_RS17275	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
HWE45_RS17280	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HWE45_RS17310	ENOG4105BZ8	glutamate synthase
HWE45_RS17325	ENOG4107QWP	ABC-2 type transporter
HWE45_RS17330	ENOG4105CJ1	ABC, transporter
HWE45_RS17345	ENOG4105C26	Dehydrogenase
HWE45_RS17350	ENOG4105DND	Transcriptional regulator
HWE45_RS17355	ENOG4105C8Y	Acetylornithine aminotransferase
HWE45_RS17380	ENOG4105EYM	Major Facilitator superfamily
HWE45_RS17395	ENOG4108KTG	Membrane protein, drug metabolite transporter
HWE45_RS17400	ENOG4105FG0	Nitroreductase
HWE45_RS17420	ENOG4107S90	membrAne
HWE45_RS17440	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
HWE45_RS17445	ENOG4108Z12	YiaAB two helix domain-containing protein
HWE45_RS17450	ENOG4105CGK	Exodeoxyribonuclease III
HWE45_RS17455	ENOG4107QP2	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
HWE45_RS17460	ENOG4105CSR	polyphosphate kinase 2
HWE45_RS17465	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
HWE45_RS17470	ENOG4105NWR	lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase
HWE45_RS17480	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
HWE45_RS17500	ENOG4105W87	Cbs domain
HWE45_RS17535	ENOG4105F2I	Transposase
HWE45_RS17560	ENOG4107RP9	extracellular solute-binding protein, family 3
HWE45_RS17565	ENOG4105CSU	acyl-Coa dehydrogenase
HWE45_RS17600	ENOG4105EA8	2-Nitropropane dioxygenase
HWE45_RS17605	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
HWE45_RS17620	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
HWE45_RS17630	ENOG4108SQ4	Glyoxalase Bleomycin resistance protein (Dioxygenase
HWE45_RS17655	ENOG4105F2I	Transposase
HWE45_RS17690	ENOG4105DWF	phosphomethylpyrimidine kinase
HWE45_RS17700	ENOG4105G6Z	alkaline phosphatase
HWE45_RS17705	ENOG4105G6Z	alkaline phosphatase
HWE45_RS17720	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
HWE45_RS17725	ENOG41086DT	Membrane protein of unknown function
HWE45_RS17730	ENOG4105SYT	Methylenetetrahydrofolate reductase
HWE45_RS17740	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
HWE45_RS17745	ENOG4107SC1	transglycosylase
HWE45_RS17760	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
HWE45_RS17765	ENOG4107RP9	extracellular solute-binding protein, family 3
HWE45_RS17770	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
HWE45_RS17775	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HWE45_RS17800	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS17805	ENOG4105ES5	Histidine kinase
HWE45_RS17815	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
HWE45_RS17820	ENOG4105D0M	Protease HtpX homolog
HWE45_RS17825	ENOG4108NIW	Leucine export protein LeuE
HWE45_RS17830	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
HWE45_RS17840	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
HWE45_RS17845	ENOG4108WZM	domain protein
HWE45_RS17850	ENOG4105C79	DNA protecting protein DprA
HWE45_RS17860	ENOG4105C9U	ATP-dependent DNA helicase RecQ
HWE45_RS17865	ENOG4105CC0	LysR family Transcriptional regulator
HWE45_RS17870	ENOG4105CEY	Amp-dependent synthetase and ligase
HWE45_RS17875	ENOG4105CNI	cell division protein FtsW
HWE45_RS17880	ENOG4105CJN	penicillin-binding protein
HWE45_RS17890	ENOG4105N3I	Involved in formation and maintenance of cell shape (By similarity)
HWE45_RS17900	ENOG41080G2	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HWE45_RS17905	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
HWE45_RS17920	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
HWE45_RS17930	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HWE45_RS17935	ENOG4105DR4	Methyltransferase
HWE45_RS17955	ENOG4105CKI	cobalamin synthesis protein
HWE45_RS17970	ENOG4105DEF	Extracellular solute-binding protein, family 5
HWE45_RS17975	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
HWE45_RS17980	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
HWE45_RS17990	ENOG4108UYB	regulatoR
HWE45_RS17995	ENOG4105TX3	Histidine kinase
HWE45_RS18020	ENOG4108WQI	RNA Polymerase
HWE45_RS18025	ENOG4105CAS	nag kinase
HWE45_RS18035	ENOG4105EC0	Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)
HWE45_RS18045	ENOG4108JPW	Aminotransferase
HWE45_RS18050	ENOG4105C26	Dehydrogenase
HWE45_RS18055	ENOG4105DWV	Homoserine O-trans-acetylase
HWE45_RS18065	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS18080	ENOG4105VCD	cytoplasmic protein
HWE45_RS18085	ENOG4105D22	carbon starvation protein
HWE45_RS18100	ENOG4105QG4	Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)
HWE45_RS18110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWE45_RS18115	ENOG4105C0M	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)
HWE45_RS18120	ENOG4108M3J	Dehydrogenase
HWE45_RS18125	ENOG4105C8E	extradiol ring-cleavage dioxygenase class IIi protein subunit b
HWE45_RS18140	ENOG4108IG5	Transcriptional regulator
HWE45_RS18145	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HWE45_RS18150	ENOG4105BZS	acriflavin resistance protein
HWE45_RS18155	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS18175	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
HWE45_RS18180	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
HWE45_RS18185	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
HWE45_RS18190	ENOG4105X5M	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
HWE45_RS18205	ENOG4105VEQ	Cold shock protein
HWE45_RS18225	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
HWE45_RS18230	ENOG4105CSH	Transporter
HWE45_RS18240	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS18245	ENOG41090T1	Membrane
HWE45_RS18265	ENOG4105C32	Amino acid ABC transporter (Permease)
HWE45_RS18270	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
HWE45_RS18275	ENOG4105C0Z	ABC transporter
HWE45_RS18280	ENOG4108IV0	ABC, transporter
HWE45_RS18315	ENOG4108V1U	phospholipid-binding protein
HWE45_RS18340	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS18360	ENOG4105DTD	Dehydrogenase
HWE45_RS18370	ENOG4108UKI	Enoyl-CoA hydratase
HWE45_RS18375	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS18405	ENOG4105F2I	Transposase
HWE45_RS18435	ENOG4105CSH	Transporter
HWE45_RS18440	ENOG4105YES	addiction module antidote protein
HWE45_RS18445	ENOG4105VUH	addiction module killer protein
HWE45_RS18450	ENOG4105EQ0	Major Facilitator superfamily
HWE45_RS18485	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
HWE45_RS18500	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
HWE45_RS18510	ENOG4105F8C	transglutaminase domain-containing protein
HWE45_RS18515	ENOG41077A9	carbonic anhydrase
HWE45_RS18550	ENOG4105C7F	AcnD-accessory protein PrpF
HWE45_RS18555	ENOG4108I0Z	Aconitate hydratase
HWE45_RS18560	ENOG4105BZN	citrate synthase
HWE45_RS18565	ENOG4105CR4	methylisocitrate lyase
HWE45_RS18570	ENOG4108JU7	Transcriptional regulator
HWE45_RS18580	ENOG4105W08	virulence gene repressor rsal
HWE45_RS18590	ENOG4105C4R	Atp-dependent dna helicase
HWE45_RS18610	ENOG4108JHT	EamA-like transporter family
HWE45_RS18625	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HWE45_RS18650	ENOG4106855	Competence protein
HWE45_RS18660	ENOG4105E4G	Type IV pilus
HWE45_RS18685	ENOG4107QHF	type ii secretion system protein e
HWE45_RS18695	ENOG4108VAU	general secretion pathway protein G
HWE45_RS18735	ENOG4107QJQ	Mate efflux family protein
HWE45_RS18740	ENOG4105WQT	MbtH domain protein
HWE45_RS18750	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
HWE45_RS18785	ENOG4105C3J	Cysteine desulfurase
HWE45_RS18790	ENOG4107QVI	Methyltransferase, type 11
HWE45_RS18840	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
HWE45_RS18870	ENOG4108VCT	Sulfite exporter TauE/SafE
HWE45_RS18910	ENOG410635M	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)
HWE45_RS18925	ENOG4105F2I	Transposase
HWE45_RS18940	ENOG4108S4H	thioesterase Superfamily protein
HWE45_RS18980	ENOG4105FYV	Amp nucleosidase
HWE45_RS18995	ENOG4105F2I	Transposase
HWE45_RS19015	ENOG4105F2I	Transposase
HWE45_RS19030	ENOG4108MGY	Histidine kinase
HWE45_RS19050	ENOG4108ZT1	Transcriptional regulator
HWE45_RS19055	ENOG4108D7R	p-hydroxycinnamoyl CoA hydratase lyase
HWE45_RS19110	ENOG4107RTM	4-alpha-glucanotransferase (EC 2.4.1.25)
HWE45_RS19115	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
HWE45_RS19130	ENOG4105CG3	alpha amylase, catalytic region
HWE45_RS19135	ENOG4105EP6	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
HWE45_RS19145	ENOG4106QJH	hemin transport protein
HWE45_RS19150	ENOG4105D05	Receptor
HWE45_RS19160	ENOG4108JU3	Alkyl hydroperoxide reductase
HWE45_RS19165	ENOG41090R7	Ferric uptake
HWE45_RS19185	ENOG4105CE1	Ferrous iron transport protein b
HWE45_RS19195	ENOG4105BZU	Histidine kinase
HWE45_RS19200	ENOG4105BZU	Histidine kinase
HWE45_RS19205	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HWE45_RS19250	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
HWE45_RS19260	ENOG4105F2I	Transposase
HWE45_RS19340	ENOG4105BZU	Histidine kinase
HWE45_RS19345	ENOG4107QTZ	amino acid
HWE45_RS19350	ENOG4107R73	Mate efflux family protein
HWE45_RS19360	ENOG4106S2D	Transcriptional regulator
HWE45_RS19370	ENOG4107BJW	polysaccharide deacetylase
HWE45_RS19375	ENOG4105CND	Glycosyl transferase, family 2
HWE45_RS19395	ENOG4108JJA	ABC, transporter
HWE45_RS19430	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS19440	ENOG4105CHR	reductase
HWE45_RS19450	ENOG4105EA8	2-Nitropropane dioxygenase
HWE45_RS19455	ENOG4105HEI	LysR family (Transcriptional regulator
HWE45_RS19460	ENOG4105U3E	Transcriptional regulator
HWE45_RS19470	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS19475	ENOG4105BZS	acriflavin resistance protein
HWE45_RS19480	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HWE45_RS19485	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HWE45_RS19490	ENOG41065SU	Two-component system sensor kinase
HWE45_RS19530	ENOG4105W1Y	Transcriptional regulator
HWE45_RS19560	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HWE45_RS19575	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HWE45_RS19580	ENOG4107QM5	aconitate hydratase
HWE45_RS19590	ENOG4107QIJ	Aconitate hydratase 2
HWE45_RS19595	ENOG41061RM	osmotically inducible lipoprotein
HWE45_RS19600	ENOG4105BZU	Histidine kinase
HWE45_RS19605	ENOG4107M1U	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS19610	ENOG4105CZE	histidine utilization repressor
HWE45_RS19615	ENOG4108Z9W	Outer membrane porin
HWE45_RS19620	ENOG4106S2D	Transcriptional regulator
HWE45_RS19635	ENOG4105CKS	Flagella basal body P-ring formation protein flgA
HWE45_RS19640	ENOG4105K88	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
HWE45_RS19645	ENOG4108ZC9	flagellar basal-body rod protein flgc
HWE45_RS19650	ENOG4105W00	Flagellar hook capping protein
HWE45_RS19655	ENOG4105BZE	flagellar hook protein, FlgE
HWE45_RS19660	ENOG4108KPB	Flagellar basal-body rod protein FlgF
HWE45_RS19665	ENOG4105CGA	flagellar basal-body rod protein FlgG
HWE45_RS19680	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
HWE45_RS19685	ENOG4105E1Q	flagellar hook-associated protein
HWE45_RS19690	ENOG4105DTJ	flagellar hook-associated protein
HWE45_RS19700	ENOG4107T3I	fad-binding protein
HWE45_RS19705	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
HWE45_RS19720	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWE45_RS19725	ENOG4105C2D	reductase
HWE45_RS19735	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
HWE45_RS19755	ENOG4105C84	Histidine ammonia-lyase
HWE45_RS19785	ENOG4107S7E	1-acyl-sn-glycerol-3-phosphate acyltransferase
HWE45_RS19795	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
HWE45_RS19805	ENOG4105CN7	Flagellar biosynthetic protein FliP
HWE45_RS19815	ENOG4105DD5	Flagellar motor switch protein
HWE45_RS19820	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HWE45_RS19830	ENOG4105BZU	Histidine kinase
HWE45_RS19835	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS19840	ENOG4105I03	Flagellin
HWE45_RS19845	ENOG4105DTS	flagellar hook-associated
HWE45_RS19850	ENOG4105MQ3	flagellar protein FliS
HWE45_RS19860	ENOG4105K56	Transcriptional regulator
HWE45_RS19880	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
HWE45_RS19885	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
HWE45_RS19890	ENOG4105W2B	Flagellar assembly protein
HWE45_RS19895	ENOG4108JIR	Flagellum-specific ATP synthase
HWE45_RS19955	ENOG4105EKQ	RNA-directed DNA polymerase
HWE45_RS19965	ENOG4105VNT	transposase (IS4 family) protein
HWE45_RS19985	ENOG4107RCI	amp-dependent synthetase and ligase
HWE45_RS20055	ENOG4105CIF	Ornithine Cyclodeaminase
HWE45_RS20060	ENOG4105DJU	Siderophore biosynthesis protein
HWE45_RS20070	ENOG4105DBM	Siderophore biosynthesis protein
HWE45_RS20075	ENOG4105DUU	IucA IucC family protein
HWE45_RS20085	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HWE45_RS20115	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS20130	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
HWE45_RS20140	ENOG4105CC0	LysR family Transcriptional regulator
HWE45_RS20145	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS20150	ENOG4105E5Q	amino acid AbC transporter
HWE45_RS20155	ENOG4105EAB	amino acid AbC transporter
HWE45_RS20160	ENOG4105EW9	transcriptional regulator AsnC family
HWE45_RS20165	ENOG4107QWB	Ornithine cyclodeaminase
HWE45_RS20185	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
HWE45_RS20220	ENOG4105K59	histidine triad (HIT) protein
HWE45_RS20260	ENOG4105F2I	Transposase
HWE45_RS20265	ENOG4105C5I	Dehydrogenase
HWE45_RS20275	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS20310	ENOG4105D64	Mechanosensitive ion channel
HWE45_RS20330	ENOG4105EQR	Transposase IS116 IS110 IS902
HWE45_RS20345	ENOG4105BZU	Histidine kinase
HWE45_RS20365	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HWE45_RS20375	ENOG4108RYK	Nad-dependent epimerase dehydratase
HWE45_RS20395	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HWE45_RS20410	ENOG4105CD8	aminopeptidase N
HWE45_RS20420	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
HWE45_RS20425	ENOG4105F2I	Transposase
HWE45_RS20460	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
HWE45_RS20465	ENOG41061MD	high-affinity nickel-transporter
HWE45_RS20505	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWE45_RS20525	ENOG4105EQR	Transposase IS116 IS110 IS902
HWE45_RS20555	ENOG4105F2I	Transposase
HWE45_RS20580	ENOG4105F2I	Transposase
HWE45_RS20585	ENOG41065HY	1,4-beta-cellobiosidase
HWE45_RS20610	ENOG4105E1F	short-chain dehydrogenase reductase
HWE45_RS20640	ENOG4108NNI	Beta-lactamase domain-containing protein
HWE45_RS20675	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
HWE45_RS20680	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
HWE45_RS20685	ENOG4105N76	Phenylacetate-CoA oxygenase, subunit
HWE45_RS20690	ENOG4105D9S	phenylacetate-CoA oxygenase PaaI subunit
HWE45_RS20695	ENOG4108ZA2	phenylacetate-CoA oxygenase PaaJ subunit
HWE45_RS20700	ENOG4105CJJ	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)
HWE45_RS20735	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
HWE45_RS20740	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
HWE45_RS20745	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
HWE45_RS20750	ENOG4107QRP	cobalamin biosynthesis protein CobW
HWE45_RS20755	ENOG4105E4R	Precorrin-3B C17-methyltransferase
HWE45_RS20770	ENOG4105DVK	Precorrin-2 c20-methyltransferase
HWE45_RS20780	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
HWE45_RS20785	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
HWE45_RS20795	ENOG4105CTK	cobaltochelatase, cobn subunit
HWE45_RS20800	ENOG4105NZG	Ferredoxin
HWE45_RS20835	ENOG4105D16	lipopolysaccharide heptosyltransferase i
HWE45_RS20845	ENOG4105CHP	RNA polymerase
HWE45_RS20855	ENOG4105IBP	Cyclic peptide transporter
HWE45_RS20865	ENOG4105WQT	MbtH domain protein
HWE45_RS20880	ENOG4105EKQ	RNA-directed DNA polymerase
HWE45_RS20895	ENOG4108ZRZ	Transcriptional regulator (AsnC family)
HWE45_RS20905	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS20910	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS20915	ENOG4105CF3	3-Hydroxyisobutyrate dehydrogenase
HWE45_RS20920	ENOG4105C26	Dehydrogenase
HWE45_RS20925	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HWE45_RS20930	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS20940	ENOG4108ZX5	transcriptional regulator
HWE45_RS20945	ENOG4105GR3	Histidine kinase
HWE45_RS20950	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWE45_RS20975	ENOG4108Z9W	Outer membrane porin
HWE45_RS20985	ENOG4105K56	Transcriptional regulator
HWE45_RS21000	ENOG4105CHJ	isochorismatase hydrolase
HWE45_RS21005	ENOG4105JQN	Transcriptional regulator
HWE45_RS21020	ENOG4107QUT	magnesium and cobalt transport protein CorA
HWE45_RS21025	ENOG4108R3E	Dna-3-methyladenine glycosylase i
HWE45_RS21030	ENOG4105DJ2	Major Facilitator Superfamily
HWE45_RS21040	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS21055	ENOG4105E39	Enoyl-CoA hydratase
HWE45_RS21065	ENOG4106B0W	Curli production assembly transport component CsgG
HWE45_RS21075	ENOG4107Y60	(LipO)protein
HWE45_RS21085	ENOG4105DZ2	Transcriptional regulator
HWE45_RS21095	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
HWE45_RS21115	ENOG4105DFA	alanine racemase domain protein
HWE45_RS21145	ENOG4105C1G	acyl-Coa dehydrogenase
HWE45_RS21190	ENOG4107791	aminotransferase class V
HWE45_RS21200	ENOG4105CHM	Aminotransferase
HWE45_RS21205	ENOG4108S2Y	peptide Chain Release factor
HWE45_RS21240	ENOG4105C0Z	ABC transporter
HWE45_RS21245	ENOG4108IV0	ABC, transporter
HWE45_RS21255	ENOG4105F2I	Transposase
HWE45_RS21310	ENOG41079HR	Phosphate-Selective Porin O and P
HWE45_RS21350	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HWE45_RS21435	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
HWE45_RS21440	ENOG4105CS6	Rhs element vgr protein
HWE45_RS21465	ENOG4105F2I	Transposase
HWE45_RS21480	ENOG4105F2I	Transposase
HWE45_RS21500	ENOG4105F32	YngK protein
HWE45_RS21575	ENOG4105F2I	Transposase
HWE45_RS21615	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
HWE45_RS21640	ENOG4107RCI	amp-dependent synthetase and ligase
HWE45_RS21660	ENOG4105C0W	non-ribosomal peptide synthetase
HWE45_RS21690	ENOG4107RGD	Major Facilitator superfamily
HWE45_RS21695	ENOG4105EKQ	RNA-directed DNA polymerase
HWE45_RS21720	ENOG4105F4P	)-transporter
HWE45_RS21745	ENOG4108Z4U	Ferredoxin
HWE45_RS21765	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
HWE45_RS21775	ENOG4105BZU	Histidine kinase
HWE45_RS21795	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS21800	ENOG4105BZS	acriflavin resistance protein
HWE45_RS21805	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HWE45_RS21815	ENOG4105FDR	Membrane
HWE45_RS21825	ENOG4107RSM	transcriptional regulator
HWE45_RS21835	ENOG4105I7M	spermidine synthase
HWE45_RS21850	ENOG4105DJB	Major Facilitator Superfamily
HWE45_RS21860	ENOG4105CTX	dehydratase
HWE45_RS21865	ENOG4105E9Z	Nad-dependent epimerase dehydratase
HWE45_RS21880	ENOG4105DPW	Major facilitator superfamily MFS_1
HWE45_RS21910	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS21960	ENOG4108SF5	RNA Polymerase
HWE45_RS21970	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS21975	ENOG4108STX	response regulator
HWE45_RS22010	ENOG4105VS8	Flagellar biosynthetic protein fliq
HWE45_RS22050	ENOG4107Y59	type iii secretion
HWE45_RS22065	ENOG4108JIR	Flagellum-specific ATP synthase
HWE45_RS22145	ENOG4105C5F	glutamine synthetase
HWE45_RS22225	ENOG4108IYT	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HWE45_RS22250	ENOG4105JQN	Transcriptional regulator
HWE45_RS22255	ENOG41061H0	Monooxygenase
HWE45_RS22260	ENOG4105ETT	transcriptional Regulator, LysR family
HWE45_RS22275	ENOG4107Z3H	Transcriptional regulator, TetR family
HWE45_RS22300	ENOG4105CMM	transposase
HWE45_RS22325	ENOG41087EV	Hsp20/alpha crystallin family
HWE45_RS22360	ENOG4107B2H	carbonic anhydrase
HWE45_RS22375	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
HWE45_RS22385	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
HWE45_RS22395	ENOG4105CMM	transposase
HWE45_RS22410	ENOG4105F2I	Transposase
HWE45_RS22425	ENOG4107EXC	regulatoR
HWE45_RS22460	ENOG4105EP1	Efflux transporter rnd family, mfp subunit
HWE45_RS22480	ENOG4106PMH	Extracellular solute-binding protein family 3
HWE45_RS22485	ENOG4105CDA	abc transporter atp-binding protein
HWE45_RS22490	ENOG4105DRP	amino acid AbC transporter
HWE45_RS22495	ENOG4108HW4	amino acid AbC transporter
HWE45_RS22515	ENOG4107R7A	Allophanate hydrolase subunit 2
HWE45_RS22520	ENOG4105P4J	Allophanate hydrolase, subunit 1
HWE45_RS22525	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
HWE45_RS22530	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
HWE45_RS22545	ENOG4105JSC	dimethylmenaquinone methyltransferase
HWE45_RS22555	ENOG4108Z67	carbohydrate kinase, thermoresistant glucokinase family
HWE45_RS22560	ENOG4105CHR	reductase
HWE45_RS22565	ENOG4105CPQ	Dehydrogenase
HWE45_RS22570	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HWE45_RS22575	ENOG4105W8H	transhydrogenase (subunit alpha
HWE45_RS22580	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
HWE45_RS22585	ENOG4108Z9W	Outer membrane porin
HWE45_RS22625	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
HWE45_RS22630	ENOG4108JUA	Transcriptional regulator
HWE45_RS22635	ENOG4105EXW	epimerase dehydratase
HWE45_RS22640	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
HWE45_RS22645	ENOG4108IMY	Transcriptional regulator
HWE45_RS22690	ENOG4105FQT	
HWE45_RS22700	ENOG4105DQQ	Major facilitator superfamily MFS_1
HWE45_RS22705	ENOG4105CRU	nitrate reductase, alpha subunit
HWE45_RS22710	ENOG4108IUE	nitrate reductase beta subunit
HWE45_RS22715	ENOG4105R3A	Nitrate reductase
HWE45_RS22720	ENOG41076YT	nitrate reductase, gamma subunit
HWE45_RS22725	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
HWE45_RS22730	ENOG4105BZU	Histidine kinase
HWE45_RS22735	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS22755	ENOG4108UB3	Thiamine monophosphate
HWE45_RS22760	ENOG4105CSH	Transporter
HWE45_RS22765	ENOG4105C0A	alcohol dehydrogenase
HWE45_RS22780	ENOG4108KF3	Electron transport protein SCO1 SenC
HWE45_RS22800	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
HWE45_RS22815	ENOG4105EJC	lysr family transcriptional regulator
HWE45_RS22860	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
HWE45_RS22865	ENOG4107WZ3	Transferase
HWE45_RS22870	ENOG4105D3Q	Sugar transferase
HWE45_RS22890	ENOG4108UW5	maltose o-acetyltransferase
HWE45_RS22975	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS23050	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
HWE45_RS23080	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
HWE45_RS23090	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
HWE45_RS23095	ENOG4105BZU	Histidine kinase
HWE45_RS23105	ENOG4105VEQ	Cold shock protein
HWE45_RS23115	ENOG4105C26	Dehydrogenase
HWE45_RS23120	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
HWE45_RS23145	ENOG4105D9R	oxidoreductase
HWE45_RS23220	ENOG4105D5K	Hemolysin activator protein
HWE45_RS23240	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS23320	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS23325	ENOG4105BZU	Histidine kinase
HWE45_RS23345	ENOG4105CMR	udp-glucose 4-epimerase
HWE45_RS23350	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
HWE45_RS23360	ENOG4108K4C	ec 3.1.3.12
HWE45_RS23365	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
HWE45_RS23370	ENOG4105K56	Transcriptional regulator
HWE45_RS23375	ENOG4108ZHJ	Organic hydroperoxide resistance protein
HWE45_RS23390	ENOG4105CBN	LysR family transcriptional regulator
HWE45_RS23400	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
HWE45_RS23410	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS23420	ENOG4105C5W	Aldolase
HWE45_RS23440	ENOG4108ZMQ	domain protein
HWE45_RS23460	ENOG4105EJC	lysr family transcriptional regulator
HWE45_RS23470	ENOG4105DQ4	alcohol dehydrogenase
HWE45_RS23495	ENOG4108VHC	Short-chain dehydrogenase reductase Sdr
HWE45_RS23525	ENOG4105DQ4	alcohol dehydrogenase
HWE45_RS23535	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
HWE45_RS23540	ENOG4108UXE	Protein tyrosine phosphatase
HWE45_RS23545	ENOG41085FC	arsR family transcriptional regulator
HWE45_RS23555	ENOG4105F2I	Transposase
HWE45_RS23560	ENOG4105F2I	Transposase
HWE45_RS23580	ENOG41064HX	Suppressor of fused protein (SUFU)
HWE45_RS23595	ENOG4105CS6	Rhs element vgr protein
HWE45_RS23600	ENOG4107RP9	extracellular solute-binding protein, family 3
HWE45_RS23605	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS23620	ENOG4105E0C	molybdate abc transporter
HWE45_RS23630	ENOG4105F4R	Transcriptional regulator mode
HWE45_RS23640	ENOG4105BZU	Histidine kinase
HWE45_RS23660	ENOG4105XDF	Protein of unknown function (DUF1272)
HWE45_RS23675	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HWE45_RS23680	ENOG4105EB3	Histidine kinase
HWE45_RS23730	ENOG4105EE5	Membrane protein terC
HWE45_RS23760	ENOG4105BZU	Histidine kinase
HWE45_RS23775	ENOG4108JJA	ABC, transporter
HWE45_RS23780	ENOG4107QZV	Type I secretion membrane fusion protein
HWE45_RS23810	ENOG4105C6Z	Gluconate
HWE45_RS23815	ENOG4108UHU	Aldolase
HWE45_RS23825	ENOG4105WH1	Two component transcriptional regulator luxr family
HWE45_RS23840	ENOG4105E0F	Histidine kinase
HWE45_RS23855	ENOG4105BZS	acriflavin resistance protein
HWE45_RS23860	ENOG4105BZS	acriflavin resistance protein
HWE45_RS23865	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS23875	ENOG4105BZU	Histidine kinase
HWE45_RS23890	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HWE45_RS23895	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HWE45_RS23900	ENOG4105BZU	Histidine kinase
HWE45_RS23905	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS23910	ENOG4105F2I	Transposase
HWE45_RS23925	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
HWE45_RS23935	ENOG4107QJQ	Mate efflux family protein
HWE45_RS23955	ENOG4108IFG	nitrite reductase, (NAD(P)H)
HWE45_RS23960	ENOG4105WZK	nitrite reductase NADPH small subunit
HWE45_RS23965	ENOG4107QZF	nitrite reductase NADPH large subunit
HWE45_RS23970	ENOG4107RNU	major facilitator superfamily MFS_1
HWE45_RS23975	ENOG4107RHT	methyl-accepting chemotaxis sensory transducer with Pas Pac sensor
HWE45_RS24005	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
HWE45_RS24010	ENOG4105JSC	dimethylmenaquinone methyltransferase
HWE45_RS24020	ENOG4105JSC	dimethylmenaquinone methyltransferase
HWE45_RS24050	ENOG4105F2I	Transposase
HWE45_RS24065	ENOG4105CVE	Lytic murein transglycosylase
HWE45_RS24075	ENOG4105C4M	(Ubiquinol oxidase) subunit I
HWE45_RS24080	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
HWE45_RS24085	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
HWE45_RS24095	ENOG4105KME	endoribonuclease L-psp
HWE45_RS24130	ENOG4105CAF	HipA N-terminal domain protein
HWE45_RS24180	ENOG4105HF0	Membrane
HWE45_RS24185	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
HWE45_RS24200	ENOG4105EJ9	Membrane
HWE45_RS24240	ENOG4105C4R	Atp-dependent dna helicase
HWE45_RS24250	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
HWE45_RS24275	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
HWE45_RS24295	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS24300	ENOG4106855	Competence protein
HWE45_RS24330	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
HWE45_RS24350	ENOG4105Z6B	inner membrane protein yjfl
HWE45_RS24355	ENOG4105EQR	Transposase IS116 IS110 IS902
HWE45_RS24380	ENOG4105F2I	Transposase
HWE45_RS24390	ENOG4105F2I	Transposase
HWE45_RS24400	ENOG4105CP9	extracellular ligand-binding receptor
HWE45_RS24415	ENOG4105C0Z	ABC transporter
HWE45_RS24420	ENOG4108IV0	ABC, transporter
HWE45_RS24465	ENOG4105F2I	Transposase
HWE45_RS24500	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS24505	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
HWE45_RS24510	ENOG4106HNH	Acyl-transferase
HWE45_RS24530	ENOG4105HEE	Binding Domain protein
HWE45_RS24535	ENOG4105DH4	Periplasmic copper-binding protein
HWE45_RS24540	ENOG4105CIG	ABC transporter
HWE45_RS24545	ENOG4108T0W	nitrous oxide maturation protein NosY
HWE45_RS24590	ENOG4105D5K	Hemolysin activator protein
HWE45_RS24605	ENOG4105EW9	transcriptional regulator AsnC family
HWE45_RS24625	ENOG4108Z8G	Alkylphosphonate utilization operon protein PhnA
HWE45_RS24635	ENOG4105GVF	(ABC) transporter
HWE45_RS24645	ENOG4108VIA	integral membrane protein
HWE45_RS24670	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS24680	ENOG4105FZW	flagellar biosynthesis regulator FlhF
HWE45_RS24685	ENOG4105D7B	Flagellar biosynthesis protein flha
HWE45_RS24690	ENOG4105D00	flagellar biosynthetic protein flhB
HWE45_RS24695	ENOG4108W9H	Tetr family transcriptional regulator
HWE45_RS24700	ENOG4105DJB	Major Facilitator Superfamily
HWE45_RS24710	ENOG4107S9B	Shikimate dehydrogenase
HWE45_RS24715	ENOG4108Z9W	Outer membrane porin
HWE45_RS24720	ENOG4105E6K	4-Hydroxyphenylpyruvate dioxygenase
HWE45_RS24725	ENOG4108KCC	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)
HWE45_RS24730	ENOG4108VYJ	response regulator receiver protein
HWE45_RS24745	ENOG4105BZU	Histidine kinase
HWE45_RS24750	ENOG4105C8Q	Methyl-accepting chemotaxis
HWE45_RS24755	ENOG4108V3W	Chemotaxis protein, CheW
HWE45_RS24760	ENOG4105CBS	Chea signal transduction histidine kinase
HWE45_RS24765	ENOG4108VYJ	response regulator receiver protein
HWE45_RS24770	ENOG4105ER2	Ompa motb domain protein
HWE45_RS24775	ENOG4107RD7	Flagellar Motor Protein, MotA
HWE45_RS24780	ENOG4106CIA	Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region
HWE45_RS24810	ENOG4108MXF	Alpha Beta Hydrolase
HWE45_RS24815	ENOG4105C0W	non-ribosomal peptide synthetase
HWE45_RS24820	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
HWE45_RS24830	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
HWE45_RS24835	ENOG4108JPW	Aminotransferase
HWE45_RS24870	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
HWE45_RS24905	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
HWE45_RS24910	ENOG4105D7W	serine acetyltransferase
HWE45_RS24915	ENOG4105EB3	Histidine kinase
HWE45_RS24940	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
HWE45_RS24950	ENOG4105CA9	Pyruvate kinase
HWE45_RS24960	ENOG4105DUM	transcriptional regulator, lysR family
HWE45_RS24970	ENOG4105F2I	Transposase
HWE45_RS24985	ENOG4105E0F	Histidine kinase
HWE45_RS24990	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
HWE45_RS25000	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
HWE45_RS25010	ENOG4105CPN	adenine deaminase
HWE45_RS25035	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
HWE45_RS25040	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
HWE45_RS25085	ENOG4105EQ2	LysR family Transcriptional regulator
HWE45_RS25095	ENOG4105CPC	Aldo Keto reductase
HWE45_RS25120	ENOG4105DUM	transcriptional regulator, lysR family
HWE45_RS25200	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
HWE45_RS25250	ENOG4105FDP	GntR family transcriptional regulator
HWE45_RS25260	ENOG4105EFS	Binding-protein-dependent transport systems, inner membrane component
HWE45_RS25295	ENOG4105DUM	transcriptional regulator, lysR family
HWE45_RS25310	ENOG4108SGR	YheO domain-containing protein
HWE45_RS25360	ENOG4105EBW	Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity)
HWE45_RS25400	ENOG4105EIN	peptidylprolyl cis-trans isomerase
HWE45_RS25405	ENOG4105D5K	Hemolysin activator protein
HWE45_RS25415	ENOG4105CKT	filamentous hemagglutinin
HWE45_RS25430	ENOG4105F2I	Transposase
HWE45_RS25465	ENOG4105C0H	protease
HWE45_RS25470	ENOG4105DHQ	Histidine kinase
HWE45_RS25475	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
HWE45_RS25500	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
HWE45_RS25505	ENOG4105C01	Dihydroxy-acid dehydratase
HWE45_RS25525	ENOG4105Z4T	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
HWE45_RS25530	ENOG4105BZ9	Cytochrome C oxidase, subunit I
HWE45_RS25540	ENOG4105CCU	oxidase (Subunit III)
HWE45_RS25565	ENOG4105CSP	Major Facilitator Superfamily
HWE45_RS25580	ENOG4106PMH	Extracellular solute-binding protein family 3
HWE45_RS25590	ENOG4105E5Q	amino acid AbC transporter
HWE45_RS25595	ENOG4105CYW	agmatinase
HWE45_RS25600	ENOG4105VJY	transcriptional regulator
HWE45_RS25610	ENOG4105CH6	catalase
HWE45_RS25615	ENOG4105F2I	Transposase
HWE45_RS25620	ENOG4105F2I	Transposase
HWE45_RS25630	ENOG4105C28	cystathionine
HWE45_RS25640	ENOG4105C26	Dehydrogenase
HWE45_RS25650	ENOG4105ETT	transcriptional Regulator, LysR family
HWE45_RS25675	ENOG4105F2I	Transposase
HWE45_RS25685	ENOG4108Z9W	Outer membrane porin
HWE45_RS25690	ENOG4108SC4	)-transporter
HWE45_RS25705	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
HWE45_RS25710	ENOG4105ENJ	RND efflux system, outer membrane lipoprotein
HWE45_RS25765	ENOG4105C26	Dehydrogenase
HWE45_RS25770	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
HWE45_RS25775	ENOG4105CNV	Aldolase
HWE45_RS25780	ENOG4105DJB	Major Facilitator Superfamily
HWE45_RS25785	ENOG4105CTX	dehydratase
HWE45_RS25790	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS25795	ENOG4105GTN	ParB Domain Protein Nuclease
HWE45_RS25805	ENOG4105BZV	Phosphoadenosine phosphosulfate reductase
HWE45_RS25820	ENOG4105F2I	Transposase
HWE45_RS25830	ENOG4105BZU	Histidine kinase
HWE45_RS25850	ENOG4105CMM	transposase
HWE45_RS25880	ENOG4108V7B	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)
HWE45_RS25885	ENOG4105TW1	Carbohydrate-selective porin OprB
HWE45_RS25890	ENOG4105DFW	ABC transporter
HWE45_RS25900	ENOG4108HWW	ABC transporter
HWE45_RS25905	ENOG4105E9Z	Nad-dependent epimerase dehydratase
HWE45_RS25910	ENOG4105ETE	Transcriptional regulator (LacI family
HWE45_RS25935	ENOG4108VN5	Inherit from COG: PepSY-associated TM helix
HWE45_RS25950	ENOG4108KTQ	Methyltransferase
HWE45_RS25965	ENOG4105EMN	RNA polymerase sigma factor
HWE45_RS26045	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
HWE45_RS26050	ENOG4108JUA	Transcriptional regulator
HWE45_RS26065	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
HWE45_RS26085	ENOG4105BZU	Histidine kinase
HWE45_RS26095	ENOG4105C7N	Xanthine uracil vitamin C permease