locus-tag	class	description
HWE45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWE45_RS00010	COG0592	DNA-directed DNA polymerase activity
HWE45_RS00025	COG3039	Transposase
HWE45_RS00055	COG3039	Transposase
HWE45_RS00080	COG3501	Rhs element vgr protein
HWE45_RS00110	COG0443	Heat shock 70 kDa protein
HWE45_RS00120	COG3039	Transposase
HWE45_RS00135	COG1475	DNA binding
HWE45_RS00150	COG3039	Transposase
HWE45_RS00185	COG2873	o-acetylhomoserine
HWE45_RS00190	COG3781	membrane
HWE45_RS00200	COG0840	transmembrane signaling receptor activity
HWE45_RS00220	COG1126	abc transporter atp-binding protein
HWE45_RS00225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS00240	COG0745	RESPONSE REGULATOR receiver
HWE45_RS00245	COG0642	Histidine kinase
HWE45_RS00260	COG2814	Major facilitator Superfamily
HWE45_RS00280	COG1959	2 iron, 2 sulfur cluster binding
HWE45_RS00305	COG0745	RESPONSE REGULATOR receiver
HWE45_RS00310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWE45_RS00330	COG2203	Gaf domain
HWE45_RS00330	COG3706	GGDEF domain
HWE45_RS00330	COG4251	negative regulation of phosphorylation
HWE45_RS00330	COG5001	Diguanylate cyclase
HWE45_RS00340	COG2205	protein histidine kinase activity
HWE45_RS00345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HWE45_RS00350	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HWE45_RS00355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HWE45_RS00370	COG3039	Transposase
HWE45_RS00395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWE45_RS00405	COG1116	anion transmembrane transporter activity
HWE45_RS00415	COG1254	Belongs to the acylphosphatase family
HWE45_RS00425	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HWE45_RS00430	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWE45_RS00440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HWE45_RS00445	COG2894	cell division
HWE45_RS00450	COG0850	regulation of cytokinetic process
HWE45_RS00455	COG0737	Belongs to the 5'-nucleotidase family
HWE45_RS00465	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWE45_RS00490	COG2154	pterin-4-alpha-carbinolamine dehydratase
HWE45_RS00495	COG3186	Phenylalanine-4-hydroxylase
HWE45_RS00510	COG2423	ornithine cyclodeaminase activity
HWE45_RS00515	COG3047	cAMP biosynthetic process
HWE45_RS00525	COG2217	Heavy metal translocating P-type atpase
HWE45_RS00530	COG0789	Transcriptional regulator
HWE45_RS00535	COG2267	carboxylic ester hydrolase activity
HWE45_RS00600	COG3530	Putative quorum-sensing-regulated virulence factor
HWE45_RS00605	COG0583	DNA-binding transcription factor activity
HWE45_RS00625	COG0445	tRNA wobble uridine modification
HWE45_RS00630	COG0357	Ribosomal RNA small subunit methyltransferase G
HWE45_RS00635	COG1192	Involved in chromosome partitioning
HWE45_RS00640	COG1475	DNA binding
HWE45_RS00650	COG0356	it plays a direct role in the translocation of protons across the membrane
HWE45_RS00660	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWE45_RS00665	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWE45_RS00670	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWE45_RS00675	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HWE45_RS00680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWE45_RS00685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWE45_RS00700	COG1832	CoA-binding protein
HWE45_RS00720	COG0625	glutathione transferase activity
HWE45_RS00750	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HWE45_RS00755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWE45_RS00760	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWE45_RS00760	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HWE45_RS00760	COG0506	proline dehydrogenase activity
HWE45_RS00765	COG0683	leucine binding
HWE45_RS00775	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HWE45_RS00780	COG1297	OPT oligopeptide transporter protein
HWE45_RS00785	COG1760	l-serine dehydratase
HWE45_RS00790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWE45_RS00790	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWE45_RS00795	COG0509	glycine decarboxylation via glycine cleavage system
HWE45_RS00800	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWE45_RS00820	COG0210	DNA helicase
HWE45_RS00840	COG2197	response regulator
HWE45_RS00845	COG3916	Acyl-homoserine-lactone synthase
HWE45_RS00855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWE45_RS00860	COG2084	Dehydrogenase
HWE45_RS00865	COG3622	Belongs to the hyi family
HWE45_RS00870	COG3960	tartronate-semialdehyde synthase activity
HWE45_RS00875	COG0583	DNA-binding transcription factor activity
HWE45_RS00890	COG1739	Uncharacterized protein family UPF0029
HWE45_RS00900	COG1301	dicarboxylic acid transport
HWE45_RS00905	COG4266	Belongs to the allantoicase family
HWE45_RS00915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWE45_RS00940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWE45_RS00955	COG0792	nuclease activity
HWE45_RS00970	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWE45_RS00980	COG4654	Cytochrome c, class I
HWE45_RS01005	COG2010	Cytochrome c
HWE45_RS01010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWE45_RS01015	COG0737	Belongs to the 5'-nucleotidase family
HWE45_RS01065	COG3846	protein secretion by the type IV secretion system
HWE45_RS01170	COG3311	Transcriptional regulator
HWE45_RS01240	COG3609	addiction module antidote protein, CC2985 family
HWE45_RS01265	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HWE45_RS01365	COG2916	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS01465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWE45_RS01485	COG3039	Transposase
HWE45_RS01510	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HWE45_RS01515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS01520	COG0402	S-adenosylhomocysteine deaminase activity
HWE45_RS01535	COG0529	Catalyzes the synthesis of activated sulfate
HWE45_RS01550	COG0457	Tetratricopeptide repeat
HWE45_RS01575	COG0493	'glutamate synthase
HWE45_RS01585	COG3385	transposase activity
HWE45_RS01590	COG1278	Cold shock
HWE45_RS01610	COG3039	Transposase
HWE45_RS01665	COG5001	Diguanylate cyclase
HWE45_RS01665	COG2203	Gaf domain
HWE45_RS01665	COG4251	negative regulation of phosphorylation
HWE45_RS01665	COG3706	GGDEF domain
HWE45_RS01680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWE45_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS01730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWE45_RS01740	COG3284	Transcriptional regulator
HWE45_RS01745	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS01750	COG4303	Ethanolamine ammonia lyase large subunit
HWE45_RS01755	COG4302	ethanolamine ammonia-lyase activity
HWE45_RS01760	COG2925	Exonuclease
HWE45_RS01875	COG1522	sequence-specific DNA binding
HWE45_RS01880	COG1404	Belongs to the peptidase S8 family
HWE45_RS01905	COG0475	glutathione-regulated potassium exporter activity
HWE45_RS01905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWE45_RS01930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS01935	COG3385	transposase activity
HWE45_RS01945	COG0745	RESPONSE REGULATOR receiver
HWE45_RS01995	COG4695	Portal protein
HWE45_RS02060	COG3039	Transposase
HWE45_RS02065	COG3039	Transposase
HWE45_RS02150	COG0863	Belongs to the N(4) N(6)-methyltransferase family
HWE45_RS02245	COG0582	viral genome integration into host DNA
HWE45_RS02280	COG2197	response regulator
HWE45_RS02285	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWE45_RS02325	COG0668	transmembrane transport
HWE45_RS02345	COG0745	RESPONSE REGULATOR receiver
HWE45_RS02350	COG2205	protein histidine kinase activity
HWE45_RS02380	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HWE45_RS02385	COG2336	PFAM SpoVT AbrB
HWE45_RS02405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWE45_RS02420	COG0395	ABC-type sugar transport system, permease component
HWE45_RS02430	COG3842	ATPase activity
HWE45_RS02445	COG1349	DNA-binding transcription factor activity
HWE45_RS02495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWE45_RS02515	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HWE45_RS02520	COG0081	regulation of translation
HWE45_RS02525	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HWE45_RS02530	COG0222	ribosome binding
HWE45_RS02535	COG0085	RNA polymerase activity
HWE45_RS02540	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HWE45_RS02545	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HWE45_RS02555	COG2373	Large extracellular alpha-helical protein
HWE45_RS02560	COG5445	Predicted secreted protein (DUF2300)
HWE45_RS02565	COG4676	Protein conserved in bacteria
HWE45_RS02570	COG4676	Protein conserved in bacteria
HWE45_RS02580	COG0514	ATP-dependent DNA helicase (RecQ)
HWE45_RS02585	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HWE45_RS02590	COG0049	tRNA binding
HWE45_RS02595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWE45_RS02600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWE45_RS02605	COG0051	transcription antitermination factor activity, RNA binding
HWE45_RS02610	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWE45_RS02615	COG0088	Forms part of the polypeptide exit tunnel
HWE45_RS02620	COG0089	rRNA binding
HWE45_RS02625	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWE45_RS02630	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HWE45_RS02635	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HWE45_RS02640	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HWE45_RS02645	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HWE45_RS02650	COG0255	Belongs to the universal ribosomal protein uL29 family
HWE45_RS02655	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HWE45_RS02660	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HWE45_RS02665	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HWE45_RS02670	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWE45_RS02675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWE45_RS02680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HWE45_RS02685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HWE45_RS02690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HWE45_RS02695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWE45_RS02700	COG1841	ribosomal large subunit assembly
HWE45_RS02705	COG0200	Binds to the 23S rRNA
HWE45_RS02710	COG0201	protein transport
HWE45_RS02715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HWE45_RS02720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWE45_RS02725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWE45_RS02730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HWE45_RS02735	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HWE45_RS02740	COG0202	RNA polymerase activity
HWE45_RS02745	COG0203	ribosomal protein L17
HWE45_RS02755	COG4232	protein-disulfide reductase activity
HWE45_RS02765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HWE45_RS02775	COG1333	cytochrome c biogenesis protein
HWE45_RS02780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWE45_RS02800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWE45_RS02805	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
HWE45_RS02820	COG1965	Belongs to the frataxin family
HWE45_RS02825	COG3385	transposase activity
HWE45_RS02860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWE45_RS02865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HWE45_RS02870	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HWE45_RS02875	COG3047	cAMP biosynthetic process
HWE45_RS02885	COG0070	glutamate synthase
HWE45_RS02885	COG0067	glutamate synthase
HWE45_RS02885	COG0069	glutamate synthase activity
HWE45_RS02900	COG1127	ABC transporter
HWE45_RS02905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWE45_RS02910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWE45_RS02930	COG1131	(ABC) transporter
HWE45_RS02935	COG0842	Transport permease protein
HWE45_RS02945	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWE45_RS02950	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWE45_RS02955	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWE45_RS02960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWE45_RS02965	COG0131	Imidazoleglycerol-phosphate dehydratase
HWE45_RS02970	COG2095	MarC family integral membrane protein
HWE45_RS02975	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWE45_RS02980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HWE45_RS02985	COG0107	imidazoleglycerol-phosphate synthase activity
HWE45_RS02990	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWE45_RS02995	COG0140	phosphoribosyl-ATP diphosphatase activity
HWE45_RS03005	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWE45_RS03010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWE45_RS03015	COG0805	protein transport
HWE45_RS03020	COG3842	ATPase activity
HWE45_RS03030	COG1840	ABC-type Fe3 transport system, periplasmic component
HWE45_RS03035	COG0642	Histidine kinase
HWE45_RS03050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS03055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWE45_RS03060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWE45_RS03065	COG1970	mechanosensitive ion channel activity
HWE45_RS03070	COG0723	plastoquinol--plastocyanin reductase activity
HWE45_RS03075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWE45_RS03080	COG2857	Cytochrome c1
HWE45_RS03085	COG0625	glutathione transferase activity
HWE45_RS03090	COG2969	positive regulation of protein catabolic process
HWE45_RS03115	COG0405	Gamma-glutamyltransferase
HWE45_RS03120	COG4774	siderophore transport
HWE45_RS03125	COG3712	iron ion homeostasis
HWE45_RS03135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWE45_RS03150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWE45_RS03155	COG0488	(ABC) transporter
HWE45_RS03175	COG2943	transferase activity, transferring hexosyl groups
HWE45_RS03175	COG3416	Protein conserved in bacteria
HWE45_RS03180	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HWE45_RS03200	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HWE45_RS03205	COG2890	protein-(glutamine-N5) methyltransferase activity
HWE45_RS03215	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWE45_RS03220	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HWE45_RS03230	COG0012	GTP binding
HWE45_RS03255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWE45_RS03265	COG0604	alcohol dehydrogenase
HWE45_RS03275	COG1289	transmembrane transporter activity
HWE45_RS03290	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HWE45_RS03300	COG0134	indole-3-glycerol-phosphate synthase activity
HWE45_RS03305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWE45_RS03315	COG0512	Glutamine amidotransferase of anthranilate synthase
HWE45_RS03325	COG0546	phosphoglycolate phosphatase activity
HWE45_RS03330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWE45_RS03335	COG2967	ApaG domain
HWE45_RS03355	COG2050	protein possibly involved in aromatic compounds catabolism
HWE45_RS03360	COG1024	Enoyl-CoA hydratase
HWE45_RS03365	COG1024	Enoyl-CoA hydratase
HWE45_RS03395	COG1473	amidohydrolase
HWE45_RS03405	COG0601	transmembrane transport
HWE45_RS03410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWE45_RS03415	COG0444	Belongs to the ABC transporter superfamily
HWE45_RS03420	COG4608	Belongs to the ABC transporter superfamily
HWE45_RS03430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWE45_RS03430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWE45_RS03435	COG1105	Belongs to the carbohydrate kinase PfkB family
HWE45_RS03440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWE45_RS03440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWE45_RS03445	COG1609	Transcriptional regulator
HWE45_RS03460	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS03465	COG0477	Major facilitator Superfamily
HWE45_RS03470	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS03475	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HWE45_RS03480	COG2001	Belongs to the MraZ family
HWE45_RS03485	COG0275	rRNA processing
HWE45_RS03500	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWE45_RS03505	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWE45_RS03510	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWE45_RS03515	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWE45_RS03525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWE45_RS03530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWE45_RS03535	COG1181	Belongs to the D-alanine--D-alanine ligase family
HWE45_RS03540	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWE45_RS03555	COG0678	peroxiredoxin activity
HWE45_RS03560	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HWE45_RS03565	COG3385	transposase activity
HWE45_RS03575	COG0739	heme binding
HWE45_RS03580	COG0653	protein targeting
HWE45_RS03585	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWE45_RS03595	COG0494	nUDIX hydrolase
HWE45_RS03600	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HWE45_RS03605	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
HWE45_RS03610	COG0237	dephospho-CoA kinase activity
HWE45_RS03620	COG1459	type II secretion system
HWE45_RS03630	COG4536	flavin adenine dinucleotide binding
HWE45_RS03640	COG0142	geranyltranstransferase activity
HWE45_RS03645	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HWE45_RS03650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWE45_RS03655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWE45_RS03660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWE45_RS03670	COG0494	nUDIX hydrolase
HWE45_RS03675	COG0442	prolyl-tRNA aminoacylation
HWE45_RS03680	COG0741	lytic transglycosylase activity
HWE45_RS03690	COG2095	MarC family integral membrane protein
HWE45_RS03700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWE45_RS03725	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWE45_RS03750	COG1522	sequence-specific DNA binding
HWE45_RS03760	COG0840	transmembrane signaling receptor activity
HWE45_RS03800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWE45_RS03805	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HWE45_RS03815	COG2264	protein methyltransferase activity
HWE45_RS03825	COG0511	ligase activity, forming carbon-carbon bonds
HWE45_RS03830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWE45_RS03835	COG3118	belongs to the thioredoxin family
HWE45_RS03845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWE45_RS03850	COG3150	esterase
HWE45_RS03855	COG3161	chorismate lyase activity
HWE45_RS03860	COG0557	exoribonuclease II activity
HWE45_RS03870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWE45_RS03875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWE45_RS03890	COG0284	orotidine-5'-phosphate decarboxylase activity
HWE45_RS03900	COG1546	Belongs to the CinA family
HWE45_RS03900	COG1058	Belongs to the CinA family
HWE45_RS03905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWE45_RS03915	COG0281	malic enzyme
HWE45_RS03915	COG0280	phosphate acetyltransferase
HWE45_RS03935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWE45_RS03945	COG0583	DNA-binding transcription factor activity
HWE45_RS03950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS03965	COG1129	ABC transporter
HWE45_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS03990	COG0800	Aldolase
HWE45_RS03995	COG4948	Mandelate Racemase Muconate Lactonizing
HWE45_RS04000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWE45_RS04005	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWE45_RS04010	COG0583	DNA-binding transcription factor activity
HWE45_RS04015	COG0735	belongs to the Fur family
HWE45_RS04020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWE45_RS04025	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HWE45_RS04030	COG0495	leucyl-tRNA aminoacylation
HWE45_RS04040	COG1466	dna polymerase III delta subunit
HWE45_RS04045	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HWE45_RS04060	COG2204	response regulator
HWE45_RS04065	COG4191	Histidine kinase
HWE45_RS04070	COG4191	Histidine kinase
HWE45_RS04095	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HWE45_RS04135	COG0482	sulfurtransferase activity
HWE45_RS04140	COG0069	glutamate synthase activity
HWE45_RS04145	COG0625	glutathione transferase activity
HWE45_RS04155	COG3038	cytochrome b561
HWE45_RS04160	COG2353	YceI-like domain
HWE45_RS04165	COG2353	YceI-like domain
HWE45_RS04170	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWE45_RS04175	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWE45_RS04180	COG1862	Preprotein translocase
HWE45_RS04185	COG0343	queuine tRNA-ribosyltransferase activity
HWE45_RS04190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HWE45_RS04195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWE45_RS04230	COG1522	sequence-specific DNA binding
HWE45_RS04235	COG1473	amidohydrolase
HWE45_RS04240	COG1819	glycosyl
HWE45_RS04255	COG3039	Transposase
HWE45_RS04275	COG1278	Cold shock
HWE45_RS04360	COG0783	Belongs to the Dps family
HWE45_RS04365	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWE45_RS04425	COG0386	Belongs to the glutathione peroxidase family
HWE45_RS04445	COG1346	cytolysis
HWE45_RS04450	COG1380	Effector of murein hydrolase LrgA
HWE45_RS04455	COG0247	lactate metabolic process
HWE45_RS04460	COG0277	FAD linked oxidase domain protein
HWE45_RS04465	COG0277	FAD linked oxidase domain protein
HWE45_RS04470	COG0583	DNA-binding transcription factor activity
HWE45_RS04475	COG0277	FAD linked oxidase domain protein
HWE45_RS04480	COG2096	Adenosyltransferase
HWE45_RS04485	COG0668	transmembrane transport
HWE45_RS04495	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWE45_RS04500	COG0312	modulator of DNA gyrase
HWE45_RS04505	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWE45_RS04515	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HWE45_RS04530	COG1404	Belongs to the peptidase S8 family
HWE45_RS04540	COG0497	DNA recombination
HWE45_RS04545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWE45_RS04550	COG1420	regulation of RNA biosynthetic process
HWE45_RS04560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HWE45_RS04565	COG2986	histidine ammonia-lyase
HWE45_RS04570	COG0010	Belongs to the arginase family
HWE45_RS04575	COG1228	amidohydrolase
HWE45_RS04580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HWE45_RS04595	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWE45_RS04605	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWE45_RS04610	COG0443	Heat shock 70 kDa protein
HWE45_RS04615	COG0484	heat shock protein binding
HWE45_RS04620	COG0512	Glutamine amidotransferase of anthranilate synthase
HWE45_RS04620	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWE45_RS04625	COG1122	ATPase activity
HWE45_RS04630	COG4662	Binding-protein-dependent transport system inner membrane component
HWE45_RS04635	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HWE45_RS04645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWE45_RS04660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWE45_RS04665	COG0628	permease
HWE45_RS04670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HWE45_RS04685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWE45_RS04685	COG2169	Transcriptional regulator
HWE45_RS04705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWE45_RS04705	COG2169	Transcriptional regulator
HWE45_RS04710	COG0456	acetyltransferase
HWE45_RS04715	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWE45_RS04720	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWE45_RS04725	COG3008	intermembrane lipid transfer
HWE45_RS04740	COG0586	Pfam SNARE associated Golgi protein
HWE45_RS04750	COG0728	peptidoglycan biosynthetic process
HWE45_RS04755	COG0268	Binds directly to 16S ribosomal RNA
HWE45_RS04765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HWE45_RS04770	COG0137	argininosuccinate synthase activity
HWE45_RS04775	COG3123	guanosine phosphorylase activity
HWE45_RS04785	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HWE45_RS04790	COG1666	GTP binding
HWE45_RS04800	COG2366	antibiotic biosynthetic process
HWE45_RS04805	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HWE45_RS04815	COG4974	Belongs to the 'phage' integrase family
HWE45_RS04835	COG3039	Transposase
HWE45_RS04840	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWE45_RS04845	COG0802	atpase or kinase
HWE45_RS04850	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWE45_RS04860	COG0583	DNA-binding transcription factor activity
HWE45_RS04880	COG0563	adenylate kinase activity
HWE45_RS04885	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HWE45_RS04890	COG2835	tetraacyldisaccharide 4'-kinase activity
HWE45_RS04895	COG1663	tetraacyldisaccharide 4'-kinase activity
HWE45_RS04905	COG0811	peptide transport
HWE45_RS04910	COG1570	exodeoxyribonuclease VII activity
HWE45_RS04915	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWE45_RS04955	COG2610	gluconate transmembrane transporter activity
HWE45_RS05005	COG1473	amidohydrolase
HWE45_RS05040	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS05045	COG2321	neutral zinc metallopeptidase
HWE45_RS05060	COG2259	Doxx family
HWE45_RS05070	COG0583	DNA-binding transcription factor activity
HWE45_RS05075	COG0583	DNA-binding transcription factor activity
HWE45_RS05095	COG1858	cytochrome C peroxidase
HWE45_RS05130	COG1278	Cold shock
HWE45_RS05135	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HWE45_RS05140	COG0542	response to heat
HWE45_RS05145	COG0756	dUTP diphosphatase activity
HWE45_RS05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWE45_RS05155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWE45_RS05165	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HWE45_RS05170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWE45_RS05175	COG0196	riboflavin kinase activity
HWE45_RS05180	COG5002	protein histidine kinase activity
HWE45_RS05180	COG0784	Response regulator, receiver
HWE45_RS05185	COG2197	response regulator
HWE45_RS05190	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWE45_RS05195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWE45_RS05195	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWE45_RS05205	COG3264	Mechanosensitive ion channel
HWE45_RS05205	COG1511	domain protein
HWE45_RS05215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWE45_RS05225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWE45_RS05230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HWE45_RS05235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWE45_RS05240	COG2003	Belongs to the UPF0758 family
HWE45_RS05245	COG1047	Peptidyl-prolyl cis-trans
HWE45_RS05250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HWE45_RS05285	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWE45_RS05320	COG2084	Dehydrogenase
HWE45_RS05330	COG0583	DNA-binding transcription factor activity
HWE45_RS05340	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWE45_RS05350	COG0175	sulfate reduction
HWE45_RS05360	COG2895	sulfate adenylyltransferase (ATP) activity
HWE45_RS05390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HWE45_RS05405	COG3385	transposase activity
HWE45_RS05410	COG0129	dihydroxy-acid dehydratase activity
HWE45_RS05415	COG0583	DNA-binding transcription factor activity
HWE45_RS05420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HWE45_RS05455	COG4206	TonB-dependent receptor
HWE45_RS05465	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HWE45_RS05470	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HWE45_RS05475	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HWE45_RS05485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWE45_RS05495	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HWE45_RS05505	COG1492	cobalamin metabolic process
HWE45_RS05525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HWE45_RS05530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWE45_RS05545	COG2911	Protein conserved in bacteria
HWE45_RS05555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWE45_RS05555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWE45_RS05560	COG3047	cAMP biosynthetic process
HWE45_RS05560	COG2885	chlorophyll binding
HWE45_RS05565	COG0489	protein tyrosine kinase activity
HWE45_RS05595	COG0243	molybdopterin cofactor binding
HWE45_RS05595	COG3383	formate dehydrogenase (NAD+) activity
HWE45_RS05600	COG0437	4 iron, 4 sulfur cluster binding
HWE45_RS05620	COG2032	superoxide dismutase activity
HWE45_RS05625	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWE45_RS05630	COG0717	Belongs to the dCTP deaminase family
HWE45_RS05635	COG1982	Orn Lys Arg decarboxylase major
HWE45_RS05680	COG0165	Argininosuccinate lyase
HWE45_RS05705	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HWE45_RS05710	COG0181	hydroxymethylbilane synthase activity
HWE45_RS05735	COG2271	Major facilitator Superfamily
HWE45_RS05750	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HWE45_RS05785	COG0492	ferredoxin-NADP+ reductase activity
HWE45_RS05790	COG1674	ftsk spoiiie
HWE45_RS05795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWE45_RS05805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWE45_RS05810	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HWE45_RS05820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWE45_RS05900	COG1846	Transcriptional regulator
HWE45_RS05910	COG2814	Major facilitator Superfamily
HWE45_RS05920	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS05925	COG1522	sequence-specific DNA binding
HWE45_RS05935	COG1522	sequence-specific DNA binding
HWE45_RS05945	COG2814	Major facilitator Superfamily
HWE45_RS05960	COG2197	response regulator
HWE45_RS06015	COG2165	general secretion pathway protein
HWE45_RS06085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWE45_RS06115	COG3039	Transposase
HWE45_RS06145	COG1253	flavin adenine dinucleotide binding
HWE45_RS06200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS06215	COG0765	amino acid transport
HWE45_RS06220	COG0765	amino acid transport
HWE45_RS06225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWE45_RS06235	COG1414	Transcriptional regulator
HWE45_RS06245	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWE45_RS06250	COG0183	Belongs to the thiolase family
HWE45_RS06260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWE45_RS06265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWE45_RS06280	COG0411	ABC transporter
HWE45_RS06290	COG0683	leucine binding
HWE45_RS06305	COG2342	PFAM TM1410 hypothetical-related protein
HWE45_RS06315	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HWE45_RS06330	COG0525	valine-tRNA ligase activity
HWE45_RS06335	COG0210	DNA helicase
HWE45_RS06345	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWE45_RS06355	COG1611	Belongs to the LOG family
HWE45_RS06360	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWE45_RS06360	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWE45_RS06365	COG1252	NADH dehydrogenase
HWE45_RS06370	COG0412	Dienelactone hydrolase
HWE45_RS06380	COG3385	transposase activity
HWE45_RS06400	COG1722	exodeoxyribonuclease VII activity
HWE45_RS06405	COG0142	geranyltranstransferase activity
HWE45_RS06410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HWE45_RS06415	COG1469	GTP cyclohydrolase I activity
HWE45_RS06420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWE45_RS06425	COG2081	HI0933 family
HWE45_RS06430	COG1610	YqeY-like protein
HWE45_RS06450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWE45_RS06460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWE45_RS06460	COG0426	domain, Protein
HWE45_RS06465	COG0513	Belongs to the DEAD box helicase family
HWE45_RS06470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWE45_RS06475	COG0583	DNA-binding transcription factor activity
HWE45_RS06480	COG1741	Belongs to the pirin family
HWE45_RS06510	COG0463	Glycosyl transferase, family 2
HWE45_RS06520	COG1132	(ABC) transporter
HWE45_RS06540	COG1530	ribonuclease E activity
HWE45_RS06545	COG0424	maF-like protein
HWE45_RS06550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HWE45_RS06555	COG0799	negative regulation of ribosome biogenesis
HWE45_RS06565	COG0408	coproporphyrinogen oxidase activity
HWE45_RS06570	COG0151	Belongs to the GarS family
HWE45_RS06575	COG0217	transcriptional regulatory protein
HWE45_RS06580	COG0433	COG0433 Predicted ATPase
HWE45_RS06585	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HWE45_RS06590	COG0697	spore germination
HWE45_RS06595	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS06600	COG1803	Methylglyoxal synthase
HWE45_RS06655	COG1129	ABC transporter
HWE45_RS06660	COG2814	Major facilitator Superfamily
HWE45_RS06665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWE45_RS06670	COG1984	allophanate hydrolase subunit 2
HWE45_RS06675	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWE45_RS06690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HWE45_RS06695	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HWE45_RS06710	COG1234	tRNA 3'-trailer cleavage
HWE45_RS06720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWE45_RS06725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWE45_RS06730	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HWE45_RS06740	COG3064	Membrane
HWE45_RS06740	COG4991	sh3 domain protein
HWE45_RS06740	COG0515	serine threonine protein kinase
HWE45_RS06745	COG1561	YicC-like family, N-terminal region
HWE45_RS06750	COG0194	GDP metabolic process
HWE45_RS06755	COG1758	RNA polymerase activity
HWE45_RS06760	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWE45_RS06790	COG1652	LysM domain
HWE45_RS06800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWE45_RS06825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWE45_RS06830	COG3842	ATPase activity
HWE45_RS06840	COG1733	regulation of RNA biosynthetic process
HWE45_RS06845	COG0166	Belongs to the GPI family
HWE45_RS06845	COG0166	Belongs to the GPI family
HWE45_RS06850	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS06875	COG0246	Mannitol dehydrogenase
HWE45_RS06880	COG1070	Carbohydrate kinase
HWE45_RS06885	COG2390	Transcriptional regulator
HWE45_RS06895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HWE45_RS06900	COG0308	aminopeptidase N
HWE45_RS06910	COG0280	phosphate acetyltransferase
HWE45_RS06910	COG0281	malic enzyme
HWE45_RS06920	COG3648	Uricase
HWE45_RS06920	COG3195	allantoin biosynthetic process
HWE45_RS06935	COG2233	PERMEase
HWE45_RS06945	COG2351	hydroxyisourate hydrolase activity
HWE45_RS06965	COG3039	Transposase
HWE45_RS06970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS06975	COG2271	Major facilitator Superfamily
HWE45_RS06980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWE45_RS06985	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS06995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS07005	COG1126	abc transporter atp-binding protein
HWE45_RS07010	COG0765	amino acid transport
HWE45_RS07015	COG0765	amino acid transport
HWE45_RS07025	COG2186	Transcriptional regulator
HWE45_RS07035	COG2119	membrane
HWE45_RS07040	COG0402	S-adenosylhomocysteine deaminase activity
HWE45_RS07045	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HWE45_RS07055	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWE45_RS07080	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HWE45_RS07105	COG1309	transcriptional regulator
HWE45_RS07115	COG0438	transferase activity, transferring glycosyl groups
HWE45_RS07150	COG0028	Belongs to the TPP enzyme family
HWE45_RS07160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWE45_RS07165	COG0688	phosphatidylethanolamine metabolic process
HWE45_RS07170	COG1183	phosphatidylcholine synthase activity
HWE45_RS07175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWE45_RS07185	COG0683	leucine binding
HWE45_RS07190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HWE45_RS07195	COG1185	polyribonucleotide nucleotidyltransferase activity
HWE45_RS07210	COG0149	triose-phosphate isomerase activity
HWE45_RS07215	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWE45_RS07225	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWE45_RS07230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWE45_RS07235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWE45_RS07240	COG0649	NAD binding
HWE45_RS07255	COG1034	ATP synthesis coupled electron transport
HWE45_RS07260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HWE45_RS07265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HWE45_RS07275	COG0713	ATP synthesis coupled electron transport
HWE45_RS07290	COG1007	ATP synthesis coupled electron transport
HWE45_RS07310	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS07315	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS07320	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS07320	COG2030	dehydratase
HWE45_RS07355	COG0829	nickel cation binding
HWE45_RS07360	COG0831	urea catabolic process
HWE45_RS07370	COG0832	Belongs to the urease beta subunit family
HWE45_RS07375	COG0804	urea catabolic process
HWE45_RS07380	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HWE45_RS07385	COG0830	nickel cation binding
HWE45_RS07390	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HWE45_RS07415	COG0625	glutathione transferase activity
HWE45_RS07420	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS07450	COG1024	Enoyl-CoA hydratase
HWE45_RS07455	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWE45_RS07460	COG0625	glutathione transferase activity
HWE45_RS07465	COG0436	Aminotransferase
HWE45_RS07475	COG3022	response to hydroperoxide
HWE45_RS07480	COG2866	Carboxypeptidase
HWE45_RS07490	COG0747	negative chemotaxis
HWE45_RS07505	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWE45_RS07530	COG0039	L-malate dehydrogenase activity
HWE45_RS07535	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS07545	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HWE45_RS07550	COG1053	succinate dehydrogenase
HWE45_RS07555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWE45_RS07560	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HWE45_RS07565	COG0372	Belongs to the citrate synthase family
HWE45_RS07570	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HWE45_RS07575	COG0066	3-isopropylmalate dehydratase activity
HWE45_RS07580	COG0473	3-isopropylmalate dehydrogenase activity
HWE45_RS07600	COG0101	tRNA pseudouridine synthase activity
HWE45_RS07605	COG0135	phosphoribosylanthranilate isomerase activity
HWE45_RS07610	COG0133	tryptophan synthase activity
HWE45_RS07620	COG0159	tryptophan synthase activity
HWE45_RS07625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HWE45_RS07630	COG0285	dihydrofolate synthase activity
HWE45_RS07650	COG0842	Transport permease protein
HWE45_RS07655	COG1131	(ABC) transporter
HWE45_RS07685	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HWE45_RS07730	COG1301	dicarboxylic acid transport
HWE45_RS07735	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWE45_RS07750	COG0697	spore germination
HWE45_RS07755	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWE45_RS07760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWE45_RS07775	COG2197	response regulator
HWE45_RS07780	COG0840	transmembrane signaling receptor activity
HWE45_RS07820	COG0747	negative chemotaxis
HWE45_RS07840	COG0601	transmembrane transport
HWE45_RS07845	COG2072	flavoprotein involved in K transport
HWE45_RS07890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWE45_RS07900	COG0582	viral genome integration into host DNA
HWE45_RS07930	COG0656	L-ascorbic acid biosynthetic process
HWE45_RS07935	COG2304	oxidoreductase activity
HWE45_RS07950	COG0589	response to stress
HWE45_RS07985	COG0328	RNA-DNA hybrid ribonuclease activity
HWE45_RS07990	COG2226	methyltransferase
HWE45_RS07995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWE45_RS08000	COG0741	lytic transglycosylase activity
HWE45_RS08000	COG1388	LysM domain
HWE45_RS08005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWE45_RS08010	COG0505	Belongs to the CarA family
HWE45_RS08020	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWE45_RS08025	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWE45_RS08035	COG1534	Rna-binding protein
HWE45_RS08040	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HWE45_RS08045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWE45_RS08050	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWE45_RS08055	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWE45_RS08060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWE45_RS08065	COG0573	inorganic phosphate transmembrane transporter activity
HWE45_RS08070	COG0581	inorganic phosphate transmembrane transporter activity
HWE45_RS08075	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWE45_RS08085	COG0745	RESPONSE REGULATOR receiver
HWE45_RS08095	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HWE45_RS08100	COG0248	Ppx GppA phosphatase
HWE45_RS08125	COG0730	response to heat
HWE45_RS08135	COG0640	Transcriptional regulator
HWE45_RS08145	COG5001	Diguanylate cyclase
HWE45_RS08145	COG3300	MHYT domain
HWE45_RS08200	COG0277	FAD linked oxidase domain protein
HWE45_RS08215	COG1295	ribonuclease BN
HWE45_RS08240	COG0477	Major facilitator Superfamily
HWE45_RS08245	COG0545	Peptidyl-prolyl cis-trans isomerase
HWE45_RS08250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HWE45_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS08265	COG4566	intracellular signal transduction
HWE45_RS08280	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS08290	COG0251	oxidation-reduction process
HWE45_RS08295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWE45_RS08305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWE45_RS08310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWE45_RS08315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HWE45_RS08320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWE45_RS08325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWE45_RS08330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWE45_RS08330	COG0072	phenylalanine-tRNA ligase activity
HWE45_RS08335	COG0776	regulation of translation
HWE45_RS08365	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWE45_RS08370	COG0531	amino acid
HWE45_RS08390	COG1846	Transcriptional regulator
HWE45_RS08400	COG0402	S-adenosylhomocysteine deaminase activity
HWE45_RS08405	COG0339	signal peptide processing
HWE45_RS08410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWE45_RS08415	COG4566	intracellular signal transduction
HWE45_RS08430	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HWE45_RS08435	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWE45_RS08445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWE45_RS08460	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWE45_RS08485	COG1414	Transcriptional regulator
HWE45_RS08515	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HWE45_RS08520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HWE45_RS08540	COG0167	dihydroorotate dehydrogenase activity
HWE45_RS08550	COG3158	transport of potassium into the cell
HWE45_RS08560	COG2183	response to ionizing radiation
HWE45_RS08575	COG1199	ATP-dependent helicase activity
HWE45_RS08585	COG0564	pseudouridine synthase activity
HWE45_RS08600	COG3243	poly(R)-hydroxyalkanoic acid synthase
HWE45_RS08605	COG0183	Belongs to the thiolase family
HWE45_RS08610	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS08620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWE45_RS08625	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWE45_RS08630	COG0183	Belongs to the thiolase family
HWE45_RS08645	COG0560	Phosphoserine phosphatase
HWE45_RS08655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWE45_RS08660	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HWE45_RS08665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HWE45_RS08670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWE45_RS08675	COG0450	alkyl hydroperoxide reductase
HWE45_RS08685	COG0745	RESPONSE REGULATOR receiver
HWE45_RS08705	COG1562	ergosterol biosynthetic process
HWE45_RS08710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS08730	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWE45_RS08730	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS08735	COG0544	peptidyl-prolyl cis-trans isomerase activity
HWE45_RS08740	COG0740	serine-type endopeptidase activity
HWE45_RS08745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HWE45_RS08750	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWE45_RS08755	COG0776	regulation of translation
HWE45_RS08770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWE45_RS08775	COG3385	transposase activity
HWE45_RS08790	COG4181	ATPase activity
HWE45_RS08795	COG0166	Belongs to the GPI family
HWE45_RS08800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWE45_RS08810	COG0047	phosphoribosylformylglycinamidine synthase activity
HWE45_RS08810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWE45_RS08835	COG0535	radical SAM domain protein
HWE45_RS08855	COG0583	DNA-binding transcription factor activity
HWE45_RS08860	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS08870	COG1176	ABC-type spermidine putrescine transport system, permease component I
HWE45_RS08880	COG3842	ATPase activity
HWE45_RS08885	COG0642	Histidine kinase
HWE45_RS08895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS08900	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HWE45_RS08925	COG1126	abc transporter atp-binding protein
HWE45_RS08930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWE45_RS08940	COG2917	probably involved in intracellular septation
HWE45_RS08945	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWE45_RS08950	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HWE45_RS08955	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS08965	COG0559	Belongs to the binding-protein-dependent transport system permease family
HWE45_RS08995	COG0833	amino acid
HWE45_RS09000	COG0833	amino acid
HWE45_RS09010	COG1335	isochorismatase
HWE45_RS09015	COG0183	Belongs to the thiolase family
HWE45_RS09020	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS09025	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS09040	COG2130	NADP-dependent
HWE45_RS09095	COG2831	hemolysin activation secretion protein
HWE45_RS09115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWE45_RS09120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWE45_RS09125	COG0470	DNA polymerase III
HWE45_RS09135	COG0084	hydrolase, TatD family'
HWE45_RS09145	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWE45_RS09150	COG1609	Transcriptional regulator
HWE45_RS09155	COG1840	ABC-type Fe3 transport system, periplasmic component
HWE45_RS09165	COG4208	sulfate ABC transporter
HWE45_RS09170	COG3842	ATPase activity
HWE45_RS09175	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWE45_RS09180	COG3023	N-Acetylmuramoyl-L-alanine amidase
HWE45_RS09215	COG0038	chloride channel
HWE45_RS09220	COG2226	methyltransferase
HWE45_RS09230	COG3433	isochorismatase activity
HWE45_RS09230	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWE45_RS09230	COG2226	methyltransferase
HWE45_RS09235	COG4771	TonB-dependent receptor
HWE45_RS09255	COG2226	methyltransferase
HWE45_RS09255	COG3433	isochorismatase activity
HWE45_RS09255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWE45_RS09275	COG0456	acetyltransferase
HWE45_RS09315	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWE45_RS09360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HWE45_RS09385	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HWE45_RS09400	COG2801	Transposase and inactivated derivatives
HWE45_RS09490	COG2814	Major facilitator Superfamily
HWE45_RS09515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS09525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWE45_RS09570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HWE45_RS09575	COG0156	8-amino-7-oxononanoate synthase activity
HWE45_RS09610	COG3045	CreA protein
HWE45_RS09650	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HWE45_RS09665	COG0840	transmembrane signaling receptor activity
HWE45_RS09675	COG3387	PFAM Glycoside hydrolase 15-related
HWE45_RS09700	COG0488	(ABC) transporter
HWE45_RS09705	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWE45_RS09715	COG0720	synthase
HWE45_RS09720	COG0602	queuosine metabolic process
HWE45_RS09735	COG3550	peptidyl-serine autophosphorylation
HWE45_RS09755	COG3485	protocatechuate 3,4-dioxygenase
HWE45_RS09760	COG3485	protocatechuate 3,4-dioxygenase
HWE45_RS09765	COG0583	DNA-binding transcription factor activity
HWE45_RS09810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWE45_RS09810	COG0519	Catalyzes the synthesis of GMP from XMP
HWE45_RS09825	COG0697	spore germination
HWE45_RS09835	COG2914	Belongs to the UPF0125 (RnfH) family
HWE45_RS09840	COG2867	negative regulation of translational initiation
HWE45_RS09845	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HWE45_RS09850	COG0330	HflC and HflK could
HWE45_RS09865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HWE45_RS09870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWE45_RS09875	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWE45_RS09880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWE45_RS09885	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWE45_RS09890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWE45_RS09895	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWE45_RS09910	COG0750	zinc metalloprotease
HWE45_RS09915	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HWE45_RS09920	COG0575	Belongs to the CDS family
HWE45_RS09925	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWE45_RS09930	COG0233	cytoplasmic translational termination
HWE45_RS09935	COG0528	UMP kinase activity
HWE45_RS09940	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HWE45_RS09945	COG0052	Belongs to the universal ribosomal protein uS2 family
HWE45_RS09950	COG0024	Methionine aminopeptidase
HWE45_RS09955	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HWE45_RS09960	COG1187	pseudouridine synthase activity
HWE45_RS09970	COG0242	peptide deformylase activity
HWE45_RS09975	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWE45_RS09990	COG0596	Alpha beta hydrolase
HWE45_RS10005	COG2171	N-acyltransferase activity
HWE45_RS10015	COG1393	Belongs to the ArsC family
HWE45_RS10020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWE45_RS10030	COG2890	protein-(glutamine-N5) methyltransferase activity
HWE45_RS10035	COG0302	gtp cyclohydrolase
HWE45_RS10060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWE45_RS10065	COG0601	transmembrane transport
HWE45_RS10070	COG0747	negative chemotaxis
HWE45_RS10075	COG4172	Belongs to the ABC transporter superfamily
HWE45_RS10090	COG0488	(ABC) transporter
HWE45_RS10100	COG1683	Conserved Protein
HWE45_RS10105	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWE45_RS10115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWE45_RS10120	COG0477	Major facilitator Superfamily
HWE45_RS10125	COG1573	uracil-dna glycosylase
HWE45_RS10135	COG1214	PFAM Peptidase M22, glycoprotease
HWE45_RS10155	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HWE45_RS10165	COG0583	DNA-binding transcription factor activity
HWE45_RS10175	COG2224	Isocitrate lyase
HWE45_RS10195	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWE45_RS10210	COG3275	phosphorelay sensor kinase activity
HWE45_RS10225	COG0583	DNA-binding transcription factor activity
HWE45_RS10230	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HWE45_RS10235	COG4208	sulfate ABC transporter
HWE45_RS10260	COG1116	anion transmembrane transporter activity
HWE45_RS10265	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWE45_RS10270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWE45_RS10275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWE45_RS10280	COG0431	NADPH-dependent FMN reductase
HWE45_RS10285	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HWE45_RS10290	COG2985	domain, Protein
HWE45_RS10295	COG0281	malic enzyme
HWE45_RS10310	COG4191	Histidine kinase
HWE45_RS10320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWE45_RS10330	COG0542	response to heat
HWE45_RS10340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWE45_RS10345	COG0314	molybdopterin synthase activity
HWE45_RS10350	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HWE45_RS10355	COG0303	'Molybdopterin
HWE45_RS10360	COG1573	uracil-dna glycosylase
HWE45_RS10375	COG0436	Aminotransferase
HWE45_RS10385	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWE45_RS10390	COG2076	Multidrug Resistance protein
HWE45_RS10395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWE45_RS10410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWE45_RS10410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWE45_RS10420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWE45_RS10425	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWE45_RS10435	COG0791	NLP P60 protein
HWE45_RS10440	COG0306	phosphate transporter
HWE45_RS10450	COG0305	Participates in initiation and elongation during chromosome replication
HWE45_RS10455	COG0359	binds to the 23S rRNA
HWE45_RS10460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWE45_RS10470	COG0360	Binds together with S18 to 16S ribosomal RNA
HWE45_RS10485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWE45_RS10495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWE45_RS10520	COG1024	Enoyl-CoA hydratase
HWE45_RS10545	COG1566	PFAM secretion protein HlyD family protein
HWE45_RS10550	COG2814	Major facilitator Superfamily
HWE45_RS10555	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWE45_RS10560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWE45_RS10565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HWE45_RS10570	COG2251	uridine kinase activity
HWE45_RS10570	COG0195	Participates in both transcription termination and antitermination
HWE45_RS10575	COG0779	Required for maturation of 30S ribosomal subunits
HWE45_RS10580	COG1187	pseudouridine synthase activity
HWE45_RS10585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWE45_RS10595	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWE45_RS10630	COG3278	Belongs to the heme-copper respiratory oxidase family
HWE45_RS10640	COG2217	Heavy metal translocating P-type atpase
HWE45_RS10650	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HWE45_RS10655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWE45_RS10660	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWE45_RS10665	COG0567	Dehydrogenase, E1 component
HWE45_RS10670	COG0584	glycerophosphoryl diester phosphodiesterase
HWE45_RS10675	COG3842	ATPase activity
HWE45_RS10685	COG1175	transmembrane transport
HWE45_RS10690	COG1653	transport
HWE45_RS10705	COG2204	response regulator
HWE45_RS10720	COG0174	glutamine synthetase
HWE45_RS10730	COG1546	Belongs to the CinA family
HWE45_RS10730	COG1058	Belongs to the CinA family
HWE45_RS10755	COG1643	Atp-dependent helicase
HWE45_RS10760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWE45_RS10760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HWE45_RS10765	COG1737	Transcriptional regulator
HWE45_RS10770	COG0673	inositol 2-dehydrogenase activity
HWE45_RS10780	COG0673	inositol 2-dehydrogenase activity
HWE45_RS10790	COG1082	Xylose isomerase domain protein TIM barrel
HWE45_RS10795	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWE45_RS10800	COG1129	ABC transporter
HWE45_RS10810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWE45_RS10815	COG3962	Belongs to the TPP enzyme family
HWE45_RS10825	COG3718	enzyme involved in inositol metabolism
HWE45_RS10835	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
HWE45_RS10845	COG1953	Uracil, thiamine, allantoin
HWE45_RS10850	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HWE45_RS10855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWE45_RS10860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWE45_RS10865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWE45_RS10870	COG0557	exoribonuclease II activity
HWE45_RS10880	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
HWE45_RS10885	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HWE45_RS10890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HWE45_RS10900	COG0330	HflC and HflK could
HWE45_RS10905	COG0330	HflC and HflK could
HWE45_RS10910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWE45_RS10915	COG1923	regulation of RNA biosynthetic process
HWE45_RS10920	COG1160	GTP binding
HWE45_RS10930	COG2976	Protein conserved in bacteria
HWE45_RS10935	COG0124	histidyl-tRNA synthetase
HWE45_RS10940	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HWE45_RS10955	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HWE45_RS10960	COG0105	UTP biosynthetic process
HWE45_RS10970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWE45_RS10990	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWE45_RS10995	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HWE45_RS11000	COG3321	synthase
HWE45_RS11000	COG0604	alcohol dehydrogenase
HWE45_RS11000	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS11005	COG1902	pentaerythritol trinitrate reductase activity
HWE45_RS11010	COG1309	transcriptional regulator
HWE45_RS11015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWE45_RS11025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWE45_RS11030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWE45_RS11045	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWE45_RS11050	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWE45_RS11055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWE45_RS11065	COG1074	ATP-dependent DNA helicase activity
HWE45_RS11080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HWE45_RS11085	COG2204	response regulator
HWE45_RS11090	COG2197	response regulator
HWE45_RS11095	COG3228	Belongs to the MtfA family
HWE45_RS11105	COG0254	rRNA binding
HWE45_RS11115	COG0534	Mate efflux family protein
HWE45_RS11150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWE45_RS11155	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWE45_RS11160	COG0791	NLP P60 protein
HWE45_RS11165	COG4172	Belongs to the ABC transporter superfamily
HWE45_RS11170	COG4239	(ABC) transporter, permease
HWE45_RS11175	COG4174	ABC transporter (Permease)
HWE45_RS11180	COG4166	transmembrane transport
HWE45_RS11195	COG0527	aspartate kinase activity
HWE45_RS11200	COG0037	tRNA processing
HWE45_RS11205	COG0825	malonyl-CoA metabolic process
HWE45_RS11210	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWE45_RS11215	COG0215	cysteine-tRNA ligase activity
HWE45_RS11230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWE45_RS11235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HWE45_RS11240	COG1045	serine acetyltransferase
HWE45_RS11255	COG1396	sequence-specific DNA binding
HWE45_RS11265	COG2258	MOSC domain
HWE45_RS11275	COG0840	transmembrane signaling receptor activity
HWE45_RS11285	COG2814	Major facilitator Superfamily
HWE45_RS11290	COG0583	DNA-binding transcription factor activity
HWE45_RS11310	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HWE45_RS11325	COG2850	peptidyl-arginine hydroxylation
HWE45_RS11335	COG1234	tRNA 3'-trailer cleavage
HWE45_RS11340	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HWE45_RS11345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWE45_RS11355	COG0180	Tryptophanyl-tRNA synthetase
HWE45_RS11360	COG1994	Peptidase M50
HWE45_RS11365	COG0009	L-threonylcarbamoyladenylate synthase
HWE45_RS11370	COG0613	PHP domain protein
HWE45_RS11375	COG0492	ferredoxin-NADP+ reductase activity
HWE45_RS11390	COG3011	Protein conserved in bacteria
HWE45_RS11395	COG2267	carboxylic ester hydrolase activity
HWE45_RS11400	COG2833	Protein of unknown function (DUF455)
HWE45_RS11410	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HWE45_RS11420	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWE45_RS11425	COG0148	phosphopyruvate hydratase activity
HWE45_RS11435	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HWE45_RS11440	COG0504	CTP synthase activity
HWE45_RS11445	COG2267	carboxylic ester hydrolase activity
HWE45_RS11465	COG2308	Evidence 4 Homologs of previously reported genes of
HWE45_RS11475	COG0084	hydrolase, TatD family'
HWE45_RS11480	COG1136	(ABC) transporter
HWE45_RS11495	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWE45_RS11500	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWE45_RS11515	COG2948	multi-organism process
HWE45_RS11530	COG3846	protein secretion by the type IV secretion system
HWE45_RS11540	COG3451	type IV secretory pathway VirB4
HWE45_RS11550	COG3838	Conjugal transfer protein Trbc
HWE45_RS11555	COG4962	Type ii secretion system protein e
HWE45_RS11570	COG3344	reverse transcriptase
HWE45_RS11590	COG3039	Transposase
HWE45_RS11615	COG4221	oxidoreductase activity
HWE45_RS11655	COG1192	Involved in chromosome partitioning
HWE45_RS11680	COG1396	sequence-specific DNA binding
HWE45_RS11685	COG5489	Protein of unknown function (DUF736)
HWE45_RS11695	COG1475	DNA binding
HWE45_RS11705	COG3077	Addiction module antitoxin, RelB DinJ family
HWE45_RS11730	COG3039	Transposase
HWE45_RS11785	COG2855	membrane
HWE45_RS11790	COG0583	DNA-binding transcription factor activity
HWE45_RS11830	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWE45_RS11830	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWE45_RS11865	COG0436	Aminotransferase
HWE45_RS11875	COG0583	DNA-binding transcription factor activity
HWE45_RS11880	COG2271	Major facilitator Superfamily
HWE45_RS11920	COG0625	glutathione transferase activity
HWE45_RS11925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS11935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS11945	COG2271	Major facilitator Superfamily
HWE45_RS11955	COG2186	Transcriptional regulator
HWE45_RS11960	COG3385	transposase activity
HWE45_RS11970	COG0745	RESPONSE REGULATOR receiver
HWE45_RS11975	COG5002	protein histidine kinase activity
HWE45_RS11985	COG0745	RESPONSE REGULATOR receiver
HWE45_RS12010	COG0322	excinuclease ABC activity
HWE45_RS12020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWE45_RS12030	COG0736	holo-[acyl-carrier-protein] synthase activity
HWE45_RS12035	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HWE45_RS12040	COG1381	Involved in DNA repair and RecF pathway recombination
HWE45_RS12045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWE45_RS12050	COG0571	ribonuclease III activity
HWE45_RS12060	COG0681	Belongs to the peptidase S26 family
HWE45_RS12065	COG0481	GTPase activity
HWE45_RS12075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWE45_RS12090	COG1595	DNA-templated transcription, initiation
HWE45_RS12100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWE45_RS12105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWE45_RS12110	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS12120	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWE45_RS12125	COG0416	fatty acid biosynthetic process
HWE45_RS12130	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HWE45_RS12135	COG1399	metal-binding, possibly nucleic acid-binding protein
HWE45_RS12140	COG0424	maF-like protein
HWE45_RS12150	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HWE45_RS12150	COG0616	signal peptide processing
HWE45_RS12160	COG0546	phosphoglycolate phosphatase activity
HWE45_RS12170	COG1530	ribonuclease E activity
HWE45_RS12175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWE45_RS12180	COG0746	molybdenum cofactor guanylyltransferase activity
HWE45_RS12195	COG1322	Protein conserved in bacteria
HWE45_RS12200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWE45_RS12215	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HWE45_RS12225	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS12230	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HWE45_RS12240	COG3385	transposase activity
HWE45_RS12255	COG0443	Heat shock 70 kDa protein
HWE45_RS12260	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HWE45_RS12270	COG0316	Belongs to the HesB IscA family
HWE45_RS12275	COG0822	iron-sulfur transferase activity
HWE45_RS12280	COG1104	cysteine desulfurase activity
HWE45_RS12290	COG1879	ABC-type sugar transport system periplasmic component
HWE45_RS12300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWE45_RS12305	COG1609	Transcriptional regulator
HWE45_RS12310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWE45_RS12320	COG0556	nucleotide-excision repair
HWE45_RS12335	COG1309	transcriptional regulator
HWE45_RS12340	COG2878	Part of a membrane complex involved in electron transport
HWE45_RS12345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWE45_RS12350	COG0778	Nitroreductase
HWE45_RS12385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWE45_RS12425	COG0326	Molecular chaperone. Has ATPase activity
HWE45_RS12430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS12435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWE45_RS12440	COG0697	spore germination
HWE45_RS12450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS12455	COG0625	glutathione transferase activity
HWE45_RS12470	COG1620	l-lactate permease
HWE45_RS12490	COG0741	lytic transglycosylase activity
HWE45_RS12540	COG0513	Belongs to the DEAD box helicase family
HWE45_RS12545	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWE45_RS12555	COG0861	Integral membrane protein TerC family
HWE45_RS12565	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWE45_RS12575	COG0312	modulator of DNA gyrase
HWE45_RS12580	COG3028	Belongs to the UPF0307 family
HWE45_RS12585	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWE45_RS12590	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HWE45_RS12595	COG0501	Belongs to the peptidase M48B family
HWE45_RS12600	COG1162	GTPase activity
HWE45_RS12610	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HWE45_RS12615	COG0494	nUDIX hydrolase
HWE45_RS12620	COG0335	large ribosomal subunit rRNA binding
HWE45_RS12625	COG0336	Belongs to the RNA methyltransferase TrmD family
HWE45_RS12630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWE45_RS12635	COG0228	four-way junction DNA binding
HWE45_RS12670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS12675	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS12695	COG2011	ABC-type metal ion transport system permease component
HWE45_RS12700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWE45_RS12705	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWE45_RS12710	COG2951	lytic endotransglycosylase activity
HWE45_RS12725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWE45_RS12730	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HWE45_RS12740	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HWE45_RS12750	COG0776	regulation of translation
HWE45_RS12760	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HWE45_RS12765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWE45_RS12770	COG0287	Prephenate dehydrogenase
HWE45_RS12775	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWE45_RS12780	COG0077	Prephenate dehydratase
HWE45_RS12780	COG1605	Chorismate mutase
HWE45_RS12785	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HWE45_RS12810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWE45_RS12870	COG3039	Transposase
HWE45_RS13000	COG2831	hemolysin activation secretion protein
HWE45_RS13170	COG3501	Rhs element vgr protein
HWE45_RS13175	COG0583	DNA-binding transcription factor activity
HWE45_RS13280	COG2916	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS13400	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HWE45_RS13625	COG3039	Transposase
HWE45_RS13645	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HWE45_RS13675	COG4221	oxidoreductase activity
HWE45_RS13800	COG1309	transcriptional regulator
HWE45_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS13810	COG0604	alcohol dehydrogenase
HWE45_RS13830	COG3039	Transposase
HWE45_RS13850	COG0778	Nitroreductase
HWE45_RS13865	COG4305	rare lipoprotein A
HWE45_RS13885	COG1280	lysine exporter protein (LysE YggA)
HWE45_RS13900	COG0425	Belongs to the sulfur carrier protein TusA family
HWE45_RS13915	COG1942	4-Oxalocrotonate Tautomerase
HWE45_RS13920	COG0235	Class ii aldolase
HWE45_RS13925	COG0477	Major facilitator Superfamily
HWE45_RS13940	COG0330	HflC and HflK could
HWE45_RS13965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWE45_RS13970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWE45_RS13995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWE45_RS14025	COG4681	YaeQ
HWE45_RS14040	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HWE45_RS14050	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS14055	COG3118	belongs to the thioredoxin family
HWE45_RS14065	COG2703	oxygen carrier activity
HWE45_RS14070	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HWE45_RS14075	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWE45_RS14080	COG2982	Protein involved in outer membrane biogenesis
HWE45_RS14105	COG0259	pyridoxamine-phosphate oxidase activity
HWE45_RS14110	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWE45_RS14120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWE45_RS14125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWE45_RS14135	COG1522	sequence-specific DNA binding
HWE45_RS14140	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HWE45_RS14150	COG3483	tryptophan 2,3-dioxygenase activity
HWE45_RS14160	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS14165	COG2252	PERMEase
HWE45_RS14170	COG0450	alkyl hydroperoxide reductase
HWE45_RS14175	COG4575	ribosome binding
HWE45_RS14195	COG1136	(ABC) transporter
HWE45_RS14200	COG0390	transport system, permease component
HWE45_RS14230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HWE45_RS14235	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HWE45_RS14240	COG0745	RESPONSE REGULATOR receiver
HWE45_RS14250	COG3385	transposase activity
HWE45_RS14260	COG2391	methyltransferase activity
HWE45_RS14265	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWE45_RS14280	COG0823	Involved in the tonB-independent uptake of proteins
HWE45_RS14300	COG0824	Thioesterase
HWE45_RS14305	COG4221	oxidoreductase activity
HWE45_RS14310	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HWE45_RS14315	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWE45_RS14380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWE45_RS14380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWE45_RS14395	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HWE45_RS14400	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWE45_RS14415	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HWE45_RS14445	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWE45_RS14450	COG1902	pentaerythritol trinitrate reductase activity
HWE45_RS14455	COG1968	undecaprenyl-diphosphatase activity
HWE45_RS14475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HWE45_RS14480	COG0425	Belongs to the sulfur carrier protein TusA family
HWE45_RS14480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWE45_RS14500	COG0859	PFAM glycosyl transferase family 9
HWE45_RS14515	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWE45_RS14550	COG1088	dTDP-glucose 4,6-dehydratase activity
HWE45_RS14555	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWE45_RS14570	COG0540	Belongs to the ATCase OTCase family
HWE45_RS14575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HWE45_RS14580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWE45_RS14585	COG1678	Uncharacterized ACR, COG1678
HWE45_RS14590	COG1187	pseudouridine synthase activity
HWE45_RS14600	COG0784	Response regulator, receiver
HWE45_RS14600	COG0643	Histidine kinase
HWE45_RS14600	COG2198	Histidine kinase
HWE45_RS14605	COG0840	transmembrane signaling receptor activity
HWE45_RS14625	COG1773	rubredoxin
HWE45_RS14630	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWE45_RS14635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWE45_RS14640	COG1704	LemA family
HWE45_RS14685	COG4964	Belongs to the GSP D family
HWE45_RS14745	COG4269	membrane
HWE45_RS14750	COG0459	protein refolding
HWE45_RS14755	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HWE45_RS14775	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWE45_RS14780	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HWE45_RS14785	COG2974	May be involved in recombination
HWE45_RS14810	COG0697	spore germination
HWE45_RS14850	COG0840	transmembrane signaling receptor activity
HWE45_RS14855	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HWE45_RS14875	COG2995	paraquat-inducible protein a
HWE45_RS14880	COG3008	intermembrane lipid transfer
HWE45_RS14880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HWE45_RS14890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS14960	COG0738	Major facilitator superfamily
HWE45_RS14965	COG2027	D-alanyl-D-alanine carboxypeptidase
HWE45_RS14970	COG1763	Mo-molybdopterin cofactor biosynthetic process
HWE45_RS14980	COG0546	phosphoglycolate phosphatase activity
HWE45_RS14990	COG0009	L-threonylcarbamoyladenylate synthase
HWE45_RS14995	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWE45_RS15000	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWE45_RS15005	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWE45_RS15015	COG0469	pyruvate kinase activity
HWE45_RS15020	COG0126	phosphoglycerate kinase activity
HWE45_RS15050	COG0859	PFAM glycosyl transferase family 9
HWE45_RS15060	COG0429	hydrolase of the alpha beta-hydrolase fold
HWE45_RS15070	COG4783	chaperone-mediated protein folding
HWE45_RS15075	COG0315	cyclic pyranopterin monophosphate synthase activity
HWE45_RS15085	COG4969	Belongs to the N-Me-Phe pilin family
HWE45_RS15110	COG0045	succinate-CoA ligase (ADP-forming) activity
HWE45_RS15120	COG2137	regulation of response to DNA damage stimulus
HWE45_RS15125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWE45_RS15135	COG0642	Histidine kinase
HWE45_RS15145	COG0477	Major facilitator Superfamily
HWE45_RS15190	COG0513	Belongs to the DEAD box helicase family
HWE45_RS15195	COG3039	Transposase
HWE45_RS15220	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS15255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWE45_RS15260	COG1702	phosphate starvation-inducible protein PhoH
HWE45_RS15265	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HWE45_RS15270	COG4535	Mg2 and Co2 transporter CorC
HWE45_RS15275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HWE45_RS15280	COG0752	glycyl-tRNA synthetase alpha subunit
HWE45_RS15290	COG0751	glycine-tRNA ligase activity
HWE45_RS15295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HWE45_RS15300	COG0204	Acyl-transferase
HWE45_RS15310	COG0346	lactoylglutathione lyase activity
HWE45_RS15315	COG0697	spore germination
HWE45_RS15320	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWE45_RS15325	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HWE45_RS15330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWE45_RS15335	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HWE45_RS15355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWE45_RS15365	COG0006	proline dipeptidase activity
HWE45_RS15370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWE45_RS15380	COG4680	protein conserved in bacteria
HWE45_RS15395	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
HWE45_RS15400	COG0138	bifunctional purine biosynthesis protein purh
HWE45_RS15405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HWE45_RS15415	COG0632	four-way junction helicase activity
HWE45_RS15420	COG2255	four-way junction helicase activity
HWE45_RS15435	COG1490	D-aminoacyl-tRNA deacylase activity
HWE45_RS15440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWE45_RS15445	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HWE45_RS15450	COG0316	Belongs to the HesB IscA family
HWE45_RS15465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWE45_RS15470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HWE45_RS15490	COG0418	dihydroorotase activity
HWE45_RS15500	COG0473	3-isopropylmalate dehydrogenase activity
HWE45_RS15505	COG0121	glutamine amidotransferase
HWE45_RS15510	COG1126	abc transporter atp-binding protein
HWE45_RS15515	COG0765	amino acid transport
HWE45_RS15520	COG0765	amino acid transport
HWE45_RS15530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWE45_RS15540	COG5265	(ABC) transporter
HWE45_RS15550	COG1024	Enoyl-CoA hydratase
HWE45_RS15555	COG0183	Belongs to the thiolase family
HWE45_RS15560	COG1024	Enoyl-CoA hydratase
HWE45_RS15560	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWE45_RS15565	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS15580	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWE45_RS15585	COG3568	Endonuclease Exonuclease Phosphatase
HWE45_RS15590	COG0494	nUDIX hydrolase
HWE45_RS15600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWE45_RS15625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HWE45_RS15640	COG2226	methyltransferase
HWE45_RS15650	COG4178	(ABC) transporter
HWE45_RS15665	COG1238	metal cluster binding
HWE45_RS15670	COG0700	Nucleoside recognition
HWE45_RS15685	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWE45_RS15690	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HWE45_RS15690	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HWE45_RS15720	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS15725	COG3265	gluconokinase activity
HWE45_RS15740	COG2391	methyltransferase activity
HWE45_RS15755	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS15770	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWE45_RS15795	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWE45_RS15830	COG0629	single-stranded DNA binding
HWE45_RS15835	COG2814	Major facilitator Superfamily
HWE45_RS15850	COG1280	lysine exporter protein (LysE YggA)
HWE45_RS15855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWE45_RS15860	COG0693	protein deglycase activity
HWE45_RS15880	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HWE45_RS15895	COG1137	ATPase activity
HWE45_RS15900	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HWE45_RS15905	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HWE45_RS15915	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HWE45_RS15925	COG1660	Displays ATPase and GTPase activities
HWE45_RS15935	COG1194	a g-specific adenine glycosylase
HWE45_RS15945	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWE45_RS15955	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
HWE45_RS15960	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HWE45_RS15970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWE45_RS15975	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HWE45_RS15980	COG0193	aminoacyl-tRNA hydrolase activity
HWE45_RS15990	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HWE45_RS15995	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HWE45_RS16000	COG0742	ribosomal rna small subunit methyltransferase
HWE45_RS16005	COG0612	Peptidase, M16
HWE45_RS16010	COG0612	Peptidase, M16
HWE45_RS16025	COG0625	glutathione transferase activity
HWE45_RS16035	COG3707	response regulator
HWE45_RS16040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWE45_RS16045	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWE45_RS16050	COG1116	anion transmembrane transporter activity
HWE45_RS16055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWE45_RS16060	COG1741	Belongs to the pirin family
HWE45_RS16070	COG3300	MHYT domain
HWE45_RS16070	COG5001	Diguanylate cyclase
HWE45_RS16075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWE45_RS16080	COG1999	signal sequence binding
HWE45_RS16085	COG0109	protoheme IX farnesyltransferase activity
HWE45_RS16090	COG1612	heme a metabolic process
HWE45_RS16120	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HWE45_RS16125	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWE45_RS16140	COG2226	methyltransferase
HWE45_RS16145	COG1040	competence protein
HWE45_RS16155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HWE45_RS16160	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HWE45_RS16165	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWE45_RS16170	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWE45_RS16175	COG0588	phosphoglycerate mutase activity
HWE45_RS16180	COG0793	Belongs to the peptidase S41A family
HWE45_RS16200	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWE45_RS16205	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWE45_RS16215	COG0189	ligase activity
HWE45_RS16225	COG0004	ammonium transporteR
HWE45_RS16390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HWE45_RS16400	COG2204	response regulator
HWE45_RS16405	COG4191	Histidine kinase
HWE45_RS16410	COG1301	dicarboxylic acid transport
HWE45_RS16415	COG3411	Ferredoxin
HWE45_RS16425	COG1686	Belongs to the peptidase S11 family
HWE45_RS16430	COG2921	Belongs to the UPF0250 family
HWE45_RS16435	COG0583	DNA-binding transcription factor activity
HWE45_RS16445	COG0321	lipoyl(octanoyl) transferase activity
HWE45_RS16450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWE45_RS16495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HWE45_RS16500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HWE45_RS16500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HWE45_RS16505	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HWE45_RS16515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HWE45_RS16540	COG1024	Enoyl-CoA hydratase
HWE45_RS16570	COG2267	carboxylic ester hydrolase activity
HWE45_RS16590	COG1410	methionine synthase
HWE45_RS16590	COG0646	methionine synthase
HWE45_RS16600	COG2197	response regulator
HWE45_RS16630	COG0018	arginyl-trna synthetase
HWE45_RS16640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWE45_RS16645	COG4221	oxidoreductase activity
HWE45_RS16655	COG3039	Transposase
HWE45_RS16660	COG3039	Transposase
HWE45_RS16680	COG3039	Transposase
HWE45_RS16685	COG3039	Transposase
HWE45_RS16695	COG3039	Transposase
HWE45_RS16715	COG3039	Transposase
HWE45_RS16735	COG0596	Alpha beta hydrolase
HWE45_RS16745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWE45_RS16765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWE45_RS16780	COG4770	biotin carboxylase activity
HWE45_RS16785	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HWE45_RS16790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HWE45_RS16800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWE45_RS16805	COG3012	SEC-C Motif Domain Protein
HWE45_RS16810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWE45_RS16825	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS16830	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS16835	COG0183	Belongs to the thiolase family
HWE45_RS16840	COG0288	reversible hydration of carbon dioxide
HWE45_RS16845	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
HWE45_RS16850	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS16855	COG0789	Transcriptional regulator
HWE45_RS16865	COG2329	Antibiotic biosynthesis monooxygenase
HWE45_RS16895	COG3039	Transposase
HWE45_RS16905	COG3039	Transposase
HWE45_RS16910	COG3039	Transposase
HWE45_RS16920	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWE45_RS16925	COG0583	DNA-binding transcription factor activity
HWE45_RS16955	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWE45_RS16955	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HWE45_RS16955	COG1703	isobutyryl-CoA mutase activity
HWE45_RS16995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWE45_RS17005	COG0430	RNA-3'-phosphate cyclase activity
HWE45_RS17010	COG3541	Predicted nucleotidyltransferase
HWE45_RS17015	COG1690	Belongs to the RtcB family
HWE45_RS17025	COG4650	regulator
HWE45_RS17040	COG1254	Belongs to the acylphosphatase family
HWE45_RS17055	COG2814	Major facilitator Superfamily
HWE45_RS17060	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS17065	COG0583	DNA-binding transcription factor activity
HWE45_RS17070	COG0519	Catalyzes the synthesis of GMP from XMP
HWE45_RS17070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWE45_RS17085	COG1733	regulation of RNA biosynthetic process
HWE45_RS17125	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HWE45_RS17135	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWE45_RS17140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HWE45_RS17145	COG0071	Belongs to the small heat shock protein (HSP20) family
HWE45_RS17155	COG3038	cytochrome b561
HWE45_RS17175	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWE45_RS17180	COG1063	alcohol dehydrogenase
HWE45_RS17190	COG2197	response regulator
HWE45_RS17195	COG3851	Histidine kinase
HWE45_RS17200	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWE45_RS17230	COG0589	response to stress
HWE45_RS17235	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HWE45_RS17255	COG0589	response to stress
HWE45_RS17260	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWE45_RS17265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWE45_RS17275	COG0037	tRNA processing
HWE45_RS17280	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWE45_RS17285	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HWE45_RS17285	COG0546	phosphoglycolate phosphatase activity
HWE45_RS17310	COG0493	'glutamate synthase
HWE45_RS17325	COG0842	Transport permease protein
HWE45_RS17330	COG1131	(ABC) transporter
HWE45_RS17345	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS17350	COG0583	DNA-binding transcription factor activity
HWE45_RS17355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWE45_RS17380	COG2223	nitrite transmembrane transporter activity
HWE45_RS17395	COG0697	spore germination
HWE45_RS17420	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HWE45_RS17440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HWE45_RS17445	COG4682	membrane
HWE45_RS17450	COG0708	Exodeoxyribonuclease III
HWE45_RS17455	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWE45_RS17460	COG2326	polyphosphate kinase activity
HWE45_RS17465	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWE45_RS17470	COG1560	Kdo2-lipid A biosynthetic process
HWE45_RS17480	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HWE45_RS17500	COG0517	IMP dehydrogenase activity
HWE45_RS17510	COG1522	sequence-specific DNA binding
HWE45_RS17535	COG3039	Transposase
HWE45_RS17565	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS17600	COG2070	2-Nitropropane dioxygenase
HWE45_RS17605	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HWE45_RS17620	COG2022	thiamine diphosphate biosynthetic process
HWE45_RS17630	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HWE45_RS17655	COG3039	Transposase
HWE45_RS17690	COG0351	phosphomethylpyrimidine kinase
HWE45_RS17700	COG1785	Belongs to the alkaline phosphatase family
HWE45_RS17705	COG1785	Belongs to the alkaline phosphatase family
HWE45_RS17720	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HWE45_RS17725	COG1950	PFAM Membrane protein of
HWE45_RS17730	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWE45_RS17740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWE45_RS17760	COG0617	tRNA 3'-terminal CCA addition
HWE45_RS17770	COG3246	L-lysine catabolic process to acetate
HWE45_RS17775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWE45_RS17800	COG2204	response regulator
HWE45_RS17805	COG5000	phosphorelay sensor kinase activity
HWE45_RS17820	COG0501	Belongs to the peptidase M48B family
HWE45_RS17830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWE45_RS17840	COG0242	peptide deformylase activity
HWE45_RS17845	COG1652	LysM domain
HWE45_RS17850	COG0758	DNA mediated transformation
HWE45_RS17865	COG0583	DNA-binding transcription factor activity
HWE45_RS17870	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS17875	COG0772	Belongs to the SEDS family
HWE45_RS17880	COG0768	penicillin binding
HWE45_RS17890	COG1792	Involved in formation and maintenance of cell shape
HWE45_RS17895	COG1077	Cell shape determining protein MreB Mrl
HWE45_RS17900	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWE45_RS17905	COG0154	amidase activity
HWE45_RS17920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWE45_RS17930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HWE45_RS17935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWE45_RS17955	COG0523	cobalamin synthesis protein
HWE45_RS17970	COG0747	negative chemotaxis
HWE45_RS17975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HWE45_RS17980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HWE45_RS17990	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
HWE45_RS18020	COG1595	DNA-templated transcription, initiation
HWE45_RS18025	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HWE45_RS18045	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWE45_RS18055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HWE45_RS18065	COG3385	transposase activity
HWE45_RS18080	COG2879	small protein
HWE45_RS18085	COG1966	Carbon starvation protein
HWE45_RS18100	COG3622	Belongs to the hyi family
HWE45_RS18110	COG0745	RESPONSE REGULATOR receiver
HWE45_RS18115	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HWE45_RS18120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWE45_RS18125	COG3384	dioxygenase
HWE45_RS18140	COG1309	transcriptional regulator
HWE45_RS18145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS18150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWE45_RS18160	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HWE45_RS18175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HWE45_RS18180	COG0706	membrane insertase activity
HWE45_RS18185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HWE45_RS18190	COG0594	ribonuclease P activity
HWE45_RS18195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HWE45_RS18205	COG1278	Cold shock
HWE45_RS18230	COG0477	Major facilitator Superfamily
HWE45_RS18235	COG4191	Histidine kinase
HWE45_RS18245	COG4377	Putative membrane peptidase family (DUF2324)
HWE45_RS18295	COG0038	chloride channel
HWE45_RS18315	COG1881	PFAM PEBP family protein
HWE45_RS18340	COG2916	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS18360	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS18370	COG1024	Enoyl-CoA hydratase
HWE45_RS18375	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS18405	COG3039	Transposase
HWE45_RS18435	COG0477	Major facilitator Superfamily
HWE45_RS18440	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWE45_RS18445	COG3657	addiction module killer protein
HWE45_RS18450	COG2814	Major facilitator Superfamily
HWE45_RS18485	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWE45_RS18500	COG0714	Associated with various cellular activities
HWE45_RS18515	COG0288	reversible hydration of carbon dioxide
HWE45_RS18565	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWE45_RS18580	COG2944	sequence-specific DNA binding
HWE45_RS18590	COG0210	DNA helicase
HWE45_RS18610	COG0697	spore germination
HWE45_RS18625	COG0446	pyridine nucleotide-disulphide oxidoreductase
HWE45_RS18625	COG1902	pentaerythritol trinitrate reductase activity
HWE45_RS18635	COG4677	pectinesterase activity
HWE45_RS18650	COG4968	Prepilin-type N-terminal cleavage methylation domain
HWE45_RS18660	COG4796	Type ii and iii secretion system protein
HWE45_RS18685	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWE45_RS18725	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HWE45_RS18735	COG0534	Mate efflux family protein
HWE45_RS18740	COG3251	PFAM MbtH domain protein
HWE45_RS18750	COG0529	Catalyzes the synthesis of activated sulfate
HWE45_RS18785	COG1104	cysteine desulfurase activity
HWE45_RS18840	COG2706	6-phosphogluconolactonase activity
HWE45_RS18870	COG0730	response to heat
HWE45_RS18910	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWE45_RS18920	COG0028	Belongs to the TPP enzyme family
HWE45_RS18925	COG3039	Transposase
HWE45_RS18940	COG1607	acyl-coa hydrolase
HWE45_RS18980	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWE45_RS18995	COG3039	Transposase
HWE45_RS19015	COG3039	Transposase
HWE45_RS19050	COG1846	Transcriptional regulator
HWE45_RS19055	COG1024	Enoyl-CoA hydratase
HWE45_RS19060	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS19100	COG2814	Major facilitator Superfamily
HWE45_RS19110	COG1640	4-alpha-glucanotransferase
HWE45_RS19115	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWE45_RS19125	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWE45_RS19130	COG0366	Alpha amylase catalytic
HWE45_RS19135	COG0366	Alpha amylase catalytic
HWE45_RS19140	COG0297	glycogen (starch) synthase activity
HWE45_RS19145	COG3720	iron ion transport
HWE45_RS19150	COG4771	TonB-dependent receptor
HWE45_RS19160	COG3634	alkyl hydroperoxide reductase activity
HWE45_RS19165	COG0735	belongs to the Fur family
HWE45_RS19185	COG1918	ferrous iron import across plasma membrane
HWE45_RS19185	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HWE45_RS19195	COG3447	MASE1 domain protein
HWE45_RS19195	COG5001	Diguanylate cyclase
HWE45_RS19195	COG5002	protein histidine kinase activity
HWE45_RS19205	COG0840	transmembrane signaling receptor activity
HWE45_RS19225	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HWE45_RS19240	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
HWE45_RS19250	COG0454	-acetyltransferase
HWE45_RS19250	COG0456	acetyltransferase
HWE45_RS19260	COG3039	Transposase
HWE45_RS19325	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HWE45_RS19340	COG3706	GGDEF domain
HWE45_RS19345	COG0531	amino acid
HWE45_RS19350	COG0534	Mate efflux family protein
HWE45_RS19360	COG2197	response regulator
HWE45_RS19370	COG0726	polysaccharide deacetylase
HWE45_RS19370	COG1649	PFAM Uncharacterised BCR, COG1649
HWE45_RS19375	COG1215	transferase activity, transferring glycosyl groups
HWE45_RS19390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS19395	COG2274	protein secretion by the type I secretion system
HWE45_RS19430	COG0840	transmembrane signaling receptor activity
HWE45_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS19450	COG2070	2-Nitropropane dioxygenase
HWE45_RS19455	COG0583	DNA-binding transcription factor activity
HWE45_RS19460	COG1695	Transcriptional regulator
HWE45_RS19475	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWE45_RS19480	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS19485	COG0745	RESPONSE REGULATOR receiver
HWE45_RS19490	COG2205	protein histidine kinase activity
HWE45_RS19505	COG0589	response to stress
HWE45_RS19530	COG0789	Transcriptional regulator
HWE45_RS19540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWE45_RS19560	COG1764	response to oxidative stress
HWE45_RS19575	COG0473	3-isopropylmalate dehydrogenase activity
HWE45_RS19605	COG2916	Histone family protein nucleoid-structuring protein H-NS
HWE45_RS19610	COG2188	Transcriptional regulator
HWE45_RS19615	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS19620	COG2197	response regulator
HWE45_RS19640	COG1815	bacterial-type flagellum-dependent cell motility
HWE45_RS19650	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HWE45_RS19655	COG1749	Flagellar hook protein flgE
HWE45_RS19660	COG4787	bacterial-type flagellum-dependent cell motility
HWE45_RS19670	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HWE45_RS19675	COG1706	bacterial-type flagellum-dependent cell motility
HWE45_RS19685	COG1256	bacterial-type flagellum assembly
HWE45_RS19705	COG2226	methyltransferase
HWE45_RS19720	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWE45_RS19725	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS19735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWE45_RS19755	COG2986	histidine ammonia-lyase
HWE45_RS19765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWE45_RS19775	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWE45_RS19785	COG0204	Acyl-transferase
HWE45_RS19800	COG1987	bacterial-type flagellum assembly
HWE45_RS19805	COG1338	Plays a role in the flagellum-specific transport system
HWE45_RS19835	COG2197	response regulator
HWE45_RS19860	COG1846	Transcriptional regulator
HWE45_RS19875	COG1677	Flagellar hook-basal body complex protein FliE
HWE45_RS19885	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWE45_RS19920	COG5001	Diguanylate cyclase
HWE45_RS19920	COG4251	negative regulation of phosphorylation
HWE45_RS19920	COG2203	Gaf domain
HWE45_RS19920	COG3706	GGDEF domain
HWE45_RS19930	COG2203	Gaf domain
HWE45_RS19930	COG3706	GGDEF domain
HWE45_RS19930	COG4251	negative regulation of phosphorylation
HWE45_RS19930	COG5001	Diguanylate cyclase
HWE45_RS19955	COG3344	reverse transcriptase
HWE45_RS19965	COG3385	transposase activity
HWE45_RS19985	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS20035	COG4774	siderophore transport
HWE45_RS20050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWE45_RS20055	COG2423	ornithine cyclodeaminase activity
HWE45_RS20060	COG4264	IucA IucC family
HWE45_RS20065	COG2814	Major facilitator Superfamily
HWE45_RS20070	COG4264	IucA IucC family
HWE45_RS20075	COG4264	IucA IucC family
HWE45_RS20085	COG0019	diaminopimelate decarboxylase activity
HWE45_RS20130	COG1902	pentaerythritol trinitrate reductase activity
HWE45_RS20140	COG0583	DNA-binding transcription factor activity
HWE45_RS20145	COG1126	abc transporter atp-binding protein
HWE45_RS20155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWE45_RS20160	COG1522	sequence-specific DNA binding
HWE45_RS20165	COG2423	ornithine cyclodeaminase activity
HWE45_RS20185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWE45_RS20220	COG0537	adenosine 5'-monophosphoramidase activity
HWE45_RS20260	COG3039	Transposase
HWE45_RS20265	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWE45_RS20275	COG0840	transmembrane signaling receptor activity
HWE45_RS20290	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWE45_RS20310	COG0668	transmembrane transport
HWE45_RS20340	COG3501	Rhs element vgr protein
HWE45_RS20345	COG3706	GGDEF domain
HWE45_RS20350	COG1914	H( )-stimulated, divalent metal cation uptake system
HWE45_RS20375	COG2910	NAD(P)H-binding
HWE45_RS20420	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWE45_RS20425	COG3039	Transposase
HWE45_RS20460	COG0402	S-adenosylhomocysteine deaminase activity
HWE45_RS20505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWE45_RS20555	COG3039	Transposase
HWE45_RS20580	COG3039	Transposase
HWE45_RS20585	COG5297	Belongs to the glycosyl hydrolase family 6
HWE45_RS20610	COG0300	oxidoreductase activity
HWE45_RS20640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWE45_RS20650	COG0835	chemotaxis
HWE45_RS20650	COG0784	Response regulator, receiver
HWE45_RS20675	COG1404	Belongs to the peptidase S8 family
HWE45_RS20680	COG3396	Phenylacetate-CoA oxygenase
HWE45_RS20685	COG3460	Phenylacetate-CoA oxygenase
HWE45_RS20690	COG3396	Phenylacetate-CoA oxygenase
HWE45_RS20695	COG2151	metal-sulfur cluster biosynthetic enzyme
HWE45_RS20700	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWE45_RS20735	COG0778	Nitroreductase
HWE45_RS20740	COG1797	cobyrinic acid a,c-diamide synthase activity
HWE45_RS20775	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HWE45_RS20785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWE45_RS20785	COG1648	precorrin-2 dehydrogenase activity
HWE45_RS20800	COG3411	Ferredoxin
HWE45_RS20805	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HWE45_RS20840	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWE45_RS20845	COG4941	Belongs to the sigma-70 factor family
HWE45_RS20860	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWE45_RS20865	COG3251	PFAM MbtH domain protein
HWE45_RS20880	COG3344	reverse transcriptase
HWE45_RS20895	COG1522	sequence-specific DNA binding
HWE45_RS20900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HWE45_RS20905	COG1024	Enoyl-CoA hydratase
HWE45_RS20910	COG1024	Enoyl-CoA hydratase
HWE45_RS20925	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWE45_RS20930	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS20945	COG5002	protein histidine kinase activity
HWE45_RS20950	COG0745	RESPONSE REGULATOR receiver
HWE45_RS20975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS20985	COG1846	Transcriptional regulator
HWE45_RS21000	COG1335	isochorismatase
HWE45_RS21010	COG2814	Major facilitator Superfamily
HWE45_RS21025	COG2818	Glycosylase
HWE45_RS21030	COG2807	transmembrane transport
HWE45_RS21055	COG1024	Enoyl-CoA hydratase
HWE45_RS21080	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWE45_RS21085	COG0583	DNA-binding transcription factor activity
HWE45_RS21090	COG0259	pyridoxamine-phosphate oxidase activity
HWE45_RS21095	COG0019	diaminopimelate decarboxylase activity
HWE45_RS21100	COG0134	indole-3-glycerol-phosphate synthase activity
HWE45_RS21105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWE45_RS21145	COG1960	acyl-CoA dehydrogenase activity
HWE45_RS21165	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
HWE45_RS21180	COG3483	tryptophan 2,3-dioxygenase activity
HWE45_RS21205	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HWE45_RS21210	COG1690	Belongs to the RtcB family
HWE45_RS21255	COG3039	Transposase
HWE45_RS21305	COG1858	cytochrome C peroxidase
HWE45_RS21310	COG1730	sister chromatid segregation
HWE45_RS21330	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HWE45_RS21350	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HWE45_RS21440	COG3501	Rhs element vgr protein
HWE45_RS21465	COG3039	Transposase
HWE45_RS21480	COG3039	Transposase
HWE45_RS21575	COG3039	Transposase
HWE45_RS21595	COG2197	response regulator
HWE45_RS21600	COG3916	Acyl-homoserine-lactone synthase
HWE45_RS21615	COG0525	valine-tRNA ligase activity
HWE45_RS21640	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS21645	COG2192	nodulation
HWE45_RS21660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWE45_RS21660	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS21660	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS21660	COG0300	oxidoreductase activity
HWE45_RS21660	COG3321	synthase
HWE45_RS21675	COG0436	Aminotransferase
HWE45_RS21690	COG2814	Major facilitator Superfamily
HWE45_RS21695	COG3344	reverse transcriptase
HWE45_RS21710	COG0587	DNA-directed DNA polymerase activity
HWE45_RS21715	COG3620	sequence-specific DNA binding
HWE45_RS21720	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWE45_RS21730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWE45_RS21745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HWE45_RS21760	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWE45_RS21765	COG4206	TonB-dependent receptor
HWE45_RS21780	COG0579	oxidoreductase
HWE45_RS21790	COG1309	transcriptional regulator
HWE45_RS21800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWE45_RS21815	COG0697	spore germination
HWE45_RS21825	COG0583	DNA-binding transcription factor activity
HWE45_RS21835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWE45_RS21840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWE45_RS21850	COG2271	Major facilitator Superfamily
HWE45_RS21860	COG2721	sulfolactate sulfo-lyase activity
HWE45_RS21865	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWE45_RS21880	COG2271	Major facilitator Superfamily
HWE45_RS21885	COG1051	belongs to the nudix hydrolase family
HWE45_RS21885	COG1056	cytidyltransferase-related domain
HWE45_RS21910	COG0840	transmembrane signaling receptor activity
HWE45_RS21960	COG1595	DNA-templated transcription, initiation
HWE45_RS21970	COG2197	response regulator
HWE45_RS21975	COG0745	RESPONSE REGULATOR receiver
HWE45_RS22015	COG4790	Type iii secretion
HWE45_RS22030	COG4789	Type iii secretion
HWE45_RS22035	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWE45_RS22080	COG2207	Transcriptional regulator
HWE45_RS22085	COG1450	Type ii and iii secretion system protein
HWE45_RS22115	COG5434	Belongs to the glycosyl hydrolase 28 family
HWE45_RS22135	COG1674	ftsk spoiiie
HWE45_RS22180	COG1942	4-Oxalocrotonate Tautomerase
HWE45_RS22185	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HWE45_RS22190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWE45_RS22195	COG2271	Major facilitator Superfamily
HWE45_RS22205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWE45_RS22225	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HWE45_RS22255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWE45_RS22260	COG0583	DNA-binding transcription factor activity
HWE45_RS22275	COG1309	transcriptional regulator
HWE45_RS22300	COG2801	Transposase and inactivated derivatives
HWE45_RS22325	COG0071	Belongs to the small heat shock protein (HSP20) family
HWE45_RS22375	COG0459	protein refolding
HWE45_RS22385	COG0415	Belongs to the DNA photolyase family
HWE45_RS22395	COG2801	Transposase and inactivated derivatives
HWE45_RS22410	COG3039	Transposase
HWE45_RS22420	COG2853	Lipoprotein
HWE45_RS22425	COG0745	RESPONSE REGULATOR receiver
HWE45_RS22435	COG2801	Transposase and inactivated derivatives
HWE45_RS22460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS22480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWE45_RS22485	COG1126	abc transporter atp-binding protein
HWE45_RS22490	COG0765	amino acid transport
HWE45_RS22495	COG0765	amino acid transport
HWE45_RS22500	COG4221	oxidoreductase activity
HWE45_RS22505	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWE45_RS22515	COG1984	allophanate hydrolase subunit 2
HWE45_RS22520	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWE45_RS22530	COG0511	ligase activity, forming carbon-carbon bonds
HWE45_RS22540	COG0436	Aminotransferase
HWE45_RS22545	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWE45_RS22555	COG3265	gluconokinase activity
HWE45_RS22560	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS22565	COG1063	alcohol dehydrogenase
HWE45_RS22585	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS22625	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
HWE45_RS22630	COG3604	Transcriptional regulator
HWE45_RS22635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWE45_RS22645	COG1396	sequence-specific DNA binding
HWE45_RS22675	COG3154	lipid carrier protein
HWE45_RS22680	COG0826	peptidase U32
HWE45_RS22685	COG0826	peptidase U32
HWE45_RS22700	COG2223	nitrite transmembrane transporter activity
HWE45_RS22705	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HWE45_RS22710	COG1140	nitrate reductase beta subunit
HWE45_RS22715	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HWE45_RS22720	COG2181	nitrate reductase activity
HWE45_RS22725	COG1763	Mo-molybdopterin cofactor biosynthetic process
HWE45_RS22730	COG3850	Histidine kinase
HWE45_RS22735	COG2197	response regulator
HWE45_RS22755	COG0352	thiamine-phosphate diphosphorylase activity
HWE45_RS22760	COG0477	Major facilitator Superfamily
HWE45_RS22765	COG1454	alcohol dehydrogenase
HWE45_RS22780	COG1999	signal sequence binding
HWE45_RS22800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWE45_RS22805	COG1301	dicarboxylic acid transport
HWE45_RS22815	COG0583	DNA-binding transcription factor activity
HWE45_RS22860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWE45_RS22870	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWE45_RS22890	COG0110	maltose O-acetyltransferase activity
HWE45_RS22905	COG2244	polysaccharide biosynthetic process
HWE45_RS22910	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HWE45_RS22915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWE45_RS22920	COG3206	protein involved in exopolysaccharide biosynthesis
HWE45_RS22920	COG0489	protein tyrosine kinase activity
HWE45_RS22925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWE45_RS22930	COG1596	polysaccharide export
HWE45_RS22975	COG0840	transmembrane signaling receptor activity
HWE45_RS23015	COG3220	belongs to the UPF0276 family
HWE45_RS23050	COG0745	RESPONSE REGULATOR receiver
HWE45_RS23075	COG2223	nitrite transmembrane transporter activity
HWE45_RS23080	COG0243	molybdopterin cofactor binding
HWE45_RS23090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWE45_RS23095	COG3300	MHYT domain
HWE45_RS23095	COG5001	Diguanylate cyclase
HWE45_RS23100	COG3158	transport of potassium into the cell
HWE45_RS23105	COG1278	Cold shock
HWE45_RS23130	COG4689	acetoacetate decarboxylase
HWE45_RS23135	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS23145	COG0673	inositol 2-dehydrogenase activity
HWE45_RS23220	COG2831	hemolysin activation secretion protein
HWE45_RS23225	COG0673	inositol 2-dehydrogenase activity
HWE45_RS23280	COG4964	Belongs to the GSP D family
HWE45_RS23320	COG2197	response regulator
HWE45_RS23345	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWE45_RS23360	COG1877	trehalose-phosphatase activity
HWE45_RS23365	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HWE45_RS23370	COG1846	Transcriptional regulator
HWE45_RS23375	COG1764	response to oxidative stress
HWE45_RS23390	COG0583	DNA-binding transcription factor activity
HWE45_RS23400	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS23440	COG2030	dehydratase
HWE45_RS23450	COG0604	alcohol dehydrogenase
HWE45_RS23450	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS23450	COG3321	synthase
HWE45_RS23460	COG0583	DNA-binding transcription factor activity
HWE45_RS23470	COG1064	alcohol dehydrogenase
HWE45_RS23495	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HWE45_RS23525	COG1064	alcohol dehydrogenase
HWE45_RS23535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWE45_RS23540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWE45_RS23545	COG0640	Transcriptional regulator
HWE45_RS23555	COG3039	Transposase
HWE45_RS23560	COG3039	Transposase
HWE45_RS23585	COG5444	nuclease activity
HWE45_RS23595	COG3501	Rhs element vgr protein
HWE45_RS23605	COG2197	response regulator
HWE45_RS23615	COG2066	Belongs to the glutaminase family
HWE45_RS23620	COG4149	molybdate abc transporter
HWE45_RS23625	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HWE45_RS23640	COG3300	MHYT domain
HWE45_RS23640	COG5001	Diguanylate cyclase
HWE45_RS23660	COG3813	Protein conserved in bacteria
HWE45_RS23675	COG0745	RESPONSE REGULATOR receiver
HWE45_RS23680	COG2205	protein histidine kinase activity
HWE45_RS23710	COG1858	cytochrome C peroxidase
HWE45_RS23730	COG1253	flavin adenine dinucleotide binding
HWE45_RS23735	COG1858	cytochrome C peroxidase
HWE45_RS23760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWE45_RS23760	COG2205	protein histidine kinase activity
HWE45_RS23775	COG2274	protein secretion by the type I secretion system
HWE45_RS23800	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HWE45_RS23815	COG0800	Aldolase
HWE45_RS23820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWE45_RS23825	COG2197	response regulator
HWE45_RS23845	COG0745	RESPONSE REGULATOR receiver
HWE45_RS23890	COG1294	oxidase, subunit
HWE45_RS23895	COG1271	oxidase subunit
HWE45_RS23900	COG5001	Diguanylate cyclase
HWE45_RS23900	COG3300	MHYT domain
HWE45_RS23905	COG0840	transmembrane signaling receptor activity
HWE45_RS23910	COG3039	Transposase
HWE45_RS23925	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWE45_RS23935	COG0534	Mate efflux family protein
HWE45_RS23950	COG0243	molybdopterin cofactor binding
HWE45_RS23955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWE45_RS23965	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWE45_RS23970	COG2223	nitrite transmembrane transporter activity
HWE45_RS23975	COG0840	transmembrane signaling receptor activity
HWE45_RS23980	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWE45_RS23990	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWE45_RS24010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWE45_RS24015	COG0436	Aminotransferase
HWE45_RS24020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HWE45_RS24050	COG3039	Transposase
HWE45_RS24065	COG2951	lytic endotransglycosylase activity
HWE45_RS24075	COG1271	oxidase subunit
HWE45_RS24080	COG1294	oxidase, subunit
HWE45_RS24085	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWE45_RS24095	COG0251	oxidation-reduction process
HWE45_RS24130	COG3550	peptidyl-serine autophosphorylation
HWE45_RS24150	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWE45_RS24175	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWE45_RS24180	COG0730	response to heat
HWE45_RS24185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWE45_RS24200	COG0730	response to heat
HWE45_RS24230	COG0668	transmembrane transport
HWE45_RS24235	COG1742	UPF0060 membrane protein
HWE45_RS24250	COG0477	Major facilitator Superfamily
HWE45_RS24255	COG0114	fumarate hydratase activity
HWE45_RS24285	COG1621	beta-fructofuranosidase activity
HWE45_RS24295	COG1609	Transcriptional regulator
HWE45_RS24300	COG4968	Prepilin-type N-terminal cleavage methylation domain
HWE45_RS24330	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HWE45_RS24350	COG3766	membrane
HWE45_RS24380	COG3039	Transposase
HWE45_RS24390	COG3039	Transposase
HWE45_RS24400	COG0683	leucine binding
HWE45_RS24425	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWE45_RS24465	COG3039	Transposase
HWE45_RS24500	COG0840	transmembrane signaling receptor activity
HWE45_RS24505	COG0567	Dehydrogenase, E1 component
HWE45_RS24510	COG0204	Acyl-transferase
HWE45_RS24525	COG4263	nitrous-oxide reductase activity
HWE45_RS24590	COG2831	hemolysin activation secretion protein
HWE45_RS24625	COG2824	Alkylphosphonate utilization operon protein PhnA
HWE45_RS24635	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWE45_RS24645	COG0762	integral membrane protein
HWE45_RS24670	COG1191	sigma factor activity
HWE45_RS24685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWE45_RS24695	COG1309	transcriptional regulator
HWE45_RS24700	COG2271	Major facilitator Superfamily
HWE45_RS24705	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWE45_RS24710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWE45_RS24715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS24725	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HWE45_RS24730	COG0745	RESPONSE REGULATOR receiver
HWE45_RS24735	COG2201	protein-glutamate methylesterase activity
HWE45_RS24740	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HWE45_RS24750	COG0840	transmembrane signaling receptor activity
HWE45_RS24755	COG0835	chemotaxis
HWE45_RS24765	COG0745	RESPONSE REGULATOR receiver
HWE45_RS24770	COG1360	Flagellar Motor Protein
HWE45_RS24805	COG0477	Major facilitator Superfamily
HWE45_RS24810	COG2267	carboxylic ester hydrolase activity
HWE45_RS24815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWE45_RS24815	COG3321	synthase
HWE45_RS24815	COG0318	PFAM AMP-dependent synthetase and ligase
HWE45_RS24815	COG0300	oxidoreductase activity
HWE45_RS24815	COG1028	Short-chain dehydrogenase reductase Sdr
HWE45_RS24820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HWE45_RS24830	COG0644	oxidoreductase
HWE45_RS24835	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWE45_RS24840	COG3486	L-lysine 6-monooxygenase (NADPH) activity
HWE45_RS24870	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
HWE45_RS24870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS24905	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWE45_RS24905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWE45_RS24910	COG1045	serine acetyltransferase
HWE45_RS24915	COG2205	protein histidine kinase activity
HWE45_RS24940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWE45_RS24950	COG0469	pyruvate kinase activity
HWE45_RS24960	COG0583	DNA-binding transcription factor activity
HWE45_RS24970	COG3039	Transposase
HWE45_RS24985	COG2205	protein histidine kinase activity
HWE45_RS24990	COG0745	RESPONSE REGULATOR receiver
HWE45_RS25000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS25010	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWE45_RS25035	COG1136	(ABC) transporter
HWE45_RS25040	COG1136	(ABC) transporter
HWE45_RS25040	COG0577	efflux transmembrane transporter activity
HWE45_RS25095	COG0667	Aldo Keto reductase
HWE45_RS25180	COG2192	nodulation
HWE45_RS25200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWE45_RS25200	COG4651	solute:proton antiporter activity
HWE45_RS25245	COG3256	nitric oxide reductase
HWE45_RS25250	COG2188	Transcriptional regulator
HWE45_RS25255	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HWE45_RS25260	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWE45_RS25295	COG0583	DNA-binding transcription factor activity
HWE45_RS25360	COG0705	Rhomboid family
HWE45_RS25380	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
HWE45_RS25400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWE45_RS25415	COG3210	domain, Protein
HWE45_RS25430	COG3039	Transposase
HWE45_RS25465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWE45_RS25470	COG0642	Histidine kinase
HWE45_RS25475	COG0745	RESPONSE REGULATOR receiver
HWE45_RS25490	COG0837	glucose binding
HWE45_RS25500	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWE45_RS25510	COG0589	response to stress
HWE45_RS25525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWE45_RS25530	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWE45_RS25540	COG1845	cytochrome c oxidase, subunit III
HWE45_RS25565	COG2271	Major facilitator Superfamily
HWE45_RS25580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWE45_RS25590	COG0765	amino acid transport
HWE45_RS25595	COG0010	Belongs to the arginase family
HWE45_RS25600	COG2197	response regulator
HWE45_RS25615	COG3039	Transposase
HWE45_RS25620	COG3039	Transposase
HWE45_RS25635	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWE45_RS25640	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS25650	COG0583	DNA-binding transcription factor activity
HWE45_RS25675	COG3039	Transposase
HWE45_RS25685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HWE45_RS25690	COG2814	Major facilitator Superfamily
HWE45_RS25705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWE45_RS25765	COG1012	belongs to the aldehyde dehydrogenase family
HWE45_RS25770	COG0473	3-isopropylmalate dehydrogenase activity
HWE45_RS25780	COG2271	Major facilitator Superfamily
HWE45_RS25785	COG2721	sulfolactate sulfo-lyase activity
HWE45_RS25795	COG1475	DNA binding
HWE45_RS25805	COG3969	phosphoadenosine phosphosulfate
HWE45_RS25810	COG5295	Hep Hag repeat protein
HWE45_RS25810	COG5295	Hep Hag repeat protein
HWE45_RS25820	COG3039	Transposase
HWE45_RS25830	COG2205	protein histidine kinase activity
HWE45_RS25830	COG0784	Response regulator, receiver
HWE45_RS25835	COG5001	Diguanylate cyclase
HWE45_RS25835	COG2203	Gaf domain
HWE45_RS25835	COG3706	GGDEF domain
HWE45_RS25835	COG4251	negative regulation of phosphorylation
HWE45_RS25880	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
HWE45_RS25890	COG4213	ABC transporter substrate-binding protein
HWE45_RS25895	COG1129	ABC transporter
HWE45_RS25900	COG4214	carbohydrate transport
HWE45_RS25905	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWE45_RS25910	COG1609	Transcriptional regulator
HWE45_RS25920	COG2207	Transcriptional regulator
HWE45_RS25965	COG1595	DNA-templated transcription, initiation
HWE45_RS25995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HWE45_RS26005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWE45_RS26020	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HWE45_RS26045	COG2204	response regulator
HWE45_RS26065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HWE45_RS26085	COG2205	protein histidine kinase activity
HWE45_RS26095	COG2252	PERMEase