locus-tag	class	description
CDC59_RS00005	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CDC59_RS00010	COG0594	ribonuclease P activity
CDC59_RS00015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CDC59_RS00020	COG0706	membrane insertase activity
CDC59_RS00025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CDC59_RS00045	COG1408	metallophosphoesterase
CDC59_RS00055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CDC59_RS00065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC59_RS00070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS00075	COG1309	transcriptional regulator
CDC59_RS00090	COG3384	dioxygenase
CDC59_RS00095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC59_RS00105	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
CDC59_RS00110	COG0745	RESPONSE REGULATOR receiver
CDC59_RS00120	COG3622	Belongs to the hyi family
CDC59_RS00135	COG1966	Carbon starvation protein
CDC59_RS00140	COG2879	small protein
CDC59_RS00160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC59_RS00170	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CDC59_RS00205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC59_RS00210	COG1595	DNA-templated transcription, initiation
CDC59_RS00240	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
CDC59_RS00265	COG1475	DNA binding
CDC59_RS00290	COG0745	RESPONSE REGULATOR receiver
CDC59_RS00370	COG3781	membrane
CDC59_RS00375	COG0840	transmembrane signaling receptor activity
CDC59_RS00390	COG0765	amino acid transport
CDC59_RS00395	COG1126	abc transporter atp-binding protein
CDC59_RS00400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS00420	COG0642	Histidine kinase
CDC59_RS00435	COG2814	Major facilitator Superfamily
CDC59_RS00450	COG1959	2 iron, 2 sulfur cluster binding
CDC59_RS00465	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
CDC59_RS00475	COG0745	RESPONSE REGULATOR receiver
CDC59_RS00480	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC59_RS00495	COG1335	isochorismatase
CDC59_RS00500	COG2197	response regulator
CDC59_RS00515	COG2205	protein histidine kinase activity
CDC59_RS00520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CDC59_RS00525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CDC59_RS00530	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CDC59_RS00545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC59_RS00560	COG1116	anion transmembrane transporter activity
CDC59_RS00570	COG1254	Belongs to the acylphosphatase family
CDC59_RS00580	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
CDC59_RS00585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC59_RS00590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CDC59_RS00595	COG2894	cell division
CDC59_RS00600	COG0850	regulation of cytokinetic process
CDC59_RS00615	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC59_RS00635	COG0642	Histidine kinase
CDC59_RS00650	COG2154	pterin-4-alpha-carbinolamine dehydratase
CDC59_RS00655	COG3186	Phenylalanine-4-hydroxylase
CDC59_RS00670	COG2423	ornithine cyclodeaminase activity
CDC59_RS00675	COG3047	cAMP biosynthetic process
CDC59_RS00690	COG0789	Transcriptional regulator
CDC59_RS00700	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CDC59_RS00770	COG0583	DNA-binding transcription factor activity
CDC59_RS00775	COG3530	Putative quorum-sensing-regulated virulence factor
CDC59_RS00795	COG0445	tRNA wobble uridine modification
CDC59_RS00800	COG0357	Ribosomal RNA small subunit methyltransferase G
CDC59_RS00805	COG1192	Involved in chromosome partitioning
CDC59_RS00810	COG1475	DNA binding
CDC59_RS00820	COG0356	it plays a direct role in the translocation of protons across the membrane
CDC59_RS00830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CDC59_RS00835	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CDC59_RS00840	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CDC59_RS00845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CDC59_RS00850	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CDC59_RS00855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC59_RS00870	COG1832	CoA-binding protein
CDC59_RS00890	COG0625	glutathione transferase activity
CDC59_RS00925	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CDC59_RS00930	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CDC59_RS00935	COG0506	proline dehydrogenase activity
CDC59_RS00935	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC59_RS00935	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC59_RS00940	COG0683	leucine binding
CDC59_RS00950	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CDC59_RS00955	COG1297	OPT oligopeptide transporter protein
CDC59_RS00965	COG3220	belongs to the UPF0276 family
CDC59_RS00975	COG1760	l-serine dehydratase
CDC59_RS00980	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC59_RS00980	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CDC59_RS00985	COG0509	glycine decarboxylation via glycine cleavage system
CDC59_RS00990	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CDC59_RS01010	COG0210	DNA helicase
CDC59_RS01045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC59_RS01050	COG0469	pyruvate kinase activity
CDC59_RS01065	COG3622	Belongs to the hyi family
CDC59_RS01070	COG3960	tartronate-semialdehyde synthase activity
CDC59_RS01075	COG0583	DNA-binding transcription factor activity
CDC59_RS01090	COG1739	Uncharacterized protein family UPF0029
CDC59_RS01100	COG1301	dicarboxylic acid transport
CDC59_RS01105	COG4266	Belongs to the allantoicase family
CDC59_RS01115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC59_RS01140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC59_RS01155	COG0792	nuclease activity
CDC59_RS01170	COG0446	pyridine nucleotide-disulphide oxidoreductase
CDC59_RS01175	COG0697	spore germination
CDC59_RS01180	COG4654	Cytochrome c, class I
CDC59_RS01205	COG2010	Cytochrome c
CDC59_RS01210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC59_RS01215	COG0737	Belongs to the 5'-nucleotidase family
CDC59_RS01235	COG0493	'glutamate synthase
CDC59_RS01260	COG0457	Tetratricopeptide repeat
CDC59_RS01275	COG0529	Catalyzes the synthesis of activated sulfate
CDC59_RS01370	COG0583	DNA-binding transcription factor activity
CDC59_RS01400	COG0529	Catalyzes the synthesis of activated sulfate
CDC59_RS01410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC59_RS01415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC59_RS01420	COG3251	PFAM MbtH domain protein
CDC59_RS01425	COG0534	Mate efflux family protein
CDC59_RS01465	COG1733	regulation of RNA biosynthetic process
CDC59_RS01475	COG0436	Aminotransferase
CDC59_RS01485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CDC59_RS01495	COG3483	tryptophan 2,3-dioxygenase activity
CDC59_RS01555	COG3706	GGDEF domain
CDC59_RS01555	COG2203	Gaf domain
CDC59_RS01555	COG5001	Diguanylate cyclase
CDC59_RS01555	COG4251	negative regulation of phosphorylation
CDC59_RS01560	COG0671	phosphoesterase, PA-phosphatase related
CDC59_RS01570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC59_RS01580	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS01590	COG0840	transmembrane signaling receptor activity
CDC59_RS01615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CDC59_RS01625	COG3284	Transcriptional regulator
CDC59_RS01635	COG4303	Ethanolamine ammonia lyase large subunit
CDC59_RS01640	COG4302	ethanolamine ammonia-lyase activity
CDC59_RS01645	COG2925	Exonuclease
CDC59_RS01760	COG1522	sequence-specific DNA binding
CDC59_RS01795	COG0475	glutathione-regulated potassium exporter activity
CDC59_RS01795	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC59_RS01865	COG0789	Transcriptional regulator
CDC59_RS01895	COG2197	response regulator
CDC59_RS01900	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CDC59_RS01935	COG2814	Major facilitator Superfamily
CDC59_RS01940	COG0668	transmembrane transport
CDC59_RS01965	COG0745	RESPONSE REGULATOR receiver
CDC59_RS01970	COG2205	protein histidine kinase activity
CDC59_RS02000	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC59_RS02025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CDC59_RS02040	COG0395	ABC-type sugar transport system, permease component
CDC59_RS02050	COG3842	ATPase activity
CDC59_RS02065	COG1349	DNA-binding transcription factor activity
CDC59_RS02120	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC59_RS02140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CDC59_RS02145	COG0081	regulation of translation
CDC59_RS02150	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CDC59_RS02155	COG0222	ribosome binding
CDC59_RS02160	COG0085	RNA polymerase activity
CDC59_RS02165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CDC59_RS02170	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
CDC59_RS02175	COG3234	Protein of unknown function (DUF1175)
CDC59_RS02180	COG2373	Large extracellular alpha-helical protein
CDC59_RS02185	COG5445	Predicted secreted protein (DUF2300)
CDC59_RS02190	COG4676	Protein conserved in bacteria
CDC59_RS02195	COG4676	Protein conserved in bacteria
CDC59_RS02205	COG0514	ATP-dependent DNA helicase (RecQ)
CDC59_RS02210	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CDC59_RS02215	COG0049	tRNA binding
CDC59_RS02225	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CDC59_RS02230	COG0051	transcription antitermination factor activity, RNA binding
CDC59_RS02235	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CDC59_RS02240	COG0088	Forms part of the polypeptide exit tunnel
CDC59_RS02245	COG0089	rRNA binding
CDC59_RS02250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CDC59_RS02255	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CDC59_RS02260	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CDC59_RS02265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CDC59_RS02270	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CDC59_RS02275	COG0255	Belongs to the universal ribosomal protein uL29 family
CDC59_RS02280	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CDC59_RS02285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CDC59_RS02290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CDC59_RS02295	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CDC59_RS02300	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CDC59_RS02305	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CDC59_RS02310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CDC59_RS02315	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CDC59_RS02320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CDC59_RS02325	COG1841	ribosomal large subunit assembly
CDC59_RS02330	COG0200	Binds to the 23S rRNA
CDC59_RS02335	COG0201	protein transport
CDC59_RS02345	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CDC59_RS02350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CDC59_RS02355	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CDC59_RS02360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CDC59_RS02365	COG0202	RNA polymerase activity
CDC59_RS02370	COG0203	ribosomal protein L17
CDC59_RS02380	COG4232	protein-disulfide reductase activity
CDC59_RS02390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CDC59_RS02400	COG1333	cytochrome c biogenesis protein
CDC59_RS02405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC59_RS02425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CDC59_RS02430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CDC59_RS02445	COG1965	Belongs to the frataxin family
CDC59_RS02480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CDC59_RS02485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CDC59_RS02490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
CDC59_RS02495	COG3047	cAMP biosynthetic process
CDC59_RS02505	COG0069	glutamate synthase activity
CDC59_RS02505	COG0070	glutamate synthase
CDC59_RS02505	COG0067	glutamate synthase
CDC59_RS02520	COG1127	ABC transporter
CDC59_RS02525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC59_RS02530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC59_RS02550	COG1131	(ABC) transporter
CDC59_RS02555	COG0842	Transport permease protein
CDC59_RS02565	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CDC59_RS02570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CDC59_RS02575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CDC59_RS02580	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC59_RS02585	COG0131	Imidazoleglycerol-phosphate dehydratase
CDC59_RS02590	COG2095	MarC family integral membrane protein
CDC59_RS02595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CDC59_RS02600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CDC59_RS02605	COG0107	imidazoleglycerol-phosphate synthase activity
CDC59_RS02610	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CDC59_RS02615	COG0140	phosphoribosyl-ATP diphosphatase activity
CDC59_RS02625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC59_RS02630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CDC59_RS02635	COG0805	protein transport
CDC59_RS02640	COG3842	ATPase activity
CDC59_RS02655	COG0642	Histidine kinase
CDC59_RS02670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS02675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC59_RS02680	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CDC59_RS02685	COG1970	mechanosensitive ion channel activity
CDC59_RS02690	COG0723	plastoquinol--plastocyanin reductase activity
CDC59_RS02695	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CDC59_RS02700	COG2857	Cytochrome c1
CDC59_RS02705	COG0625	glutathione transferase activity
CDC59_RS02710	COG2969	positive regulation of protein catabolic process
CDC59_RS02730	COG0405	Gamma-glutamyltransferase
CDC59_RS02735	COG4774	siderophore transport
CDC59_RS02740	COG3712	iron ion homeostasis
CDC59_RS02750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC59_RS02765	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
CDC59_RS02770	COG0488	(ABC) transporter
CDC59_RS02790	COG3416	Protein conserved in bacteria
CDC59_RS02790	COG2943	transferase activity, transferring hexosyl groups
CDC59_RS02795	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC59_RS02810	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
CDC59_RS02815	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC59_RS02825	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CDC59_RS02830	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CDC59_RS02840	COG0012	GTP binding
CDC59_RS02865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC59_RS02875	COG0604	alcohol dehydrogenase
CDC59_RS02880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC59_RS02885	COG1289	transmembrane transporter activity
CDC59_RS02890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CDC59_RS02895	COG3025	triphosphatase activity
CDC59_RS02900	COG0134	indole-3-glycerol-phosphate synthase activity
CDC59_RS02905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC59_RS02915	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC59_RS02925	COG0546	phosphoglycolate phosphatase activity
CDC59_RS02930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CDC59_RS02935	COG2967	ApaG domain
CDC59_RS02955	COG2050	protein possibly involved in aromatic compounds catabolism
CDC59_RS02960	COG1024	Enoyl-CoA hydratase
CDC59_RS02965	COG1024	Enoyl-CoA hydratase
CDC59_RS02995	COG1473	amidohydrolase
CDC59_RS03000	COG0747	negative chemotaxis
CDC59_RS03005	COG0601	transmembrane transport
CDC59_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC59_RS03020	COG4608	Belongs to the ABC transporter superfamily
CDC59_RS03035	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC59_RS03035	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CDC59_RS03040	COG1105	Belongs to the carbohydrate kinase PfkB family
CDC59_RS03045	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC59_RS03045	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC59_RS03050	COG1609	Transcriptional regulator
CDC59_RS03055	COG0243	molybdopterin cofactor binding
CDC59_RS03065	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS03070	COG0477	Major facilitator Superfamily
CDC59_RS03075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS03080	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
CDC59_RS03085	COG2001	Belongs to the MraZ family
CDC59_RS03090	COG0275	rRNA processing
CDC59_RS03095	COG3116	cell division
CDC59_RS03105	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CDC59_RS03110	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CDC59_RS03115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CDC59_RS03120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CDC59_RS03130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CDC59_RS03135	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC59_RS03140	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC59_RS03145	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CDC59_RS03160	COG0678	peroxiredoxin activity
CDC59_RS03165	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CDC59_RS03175	COG0739	heme binding
CDC59_RS03180	COG0653	protein targeting
CDC59_RS03185	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CDC59_RS03195	COG0494	nUDIX hydrolase
CDC59_RS03200	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
CDC59_RS03205	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
CDC59_RS03210	COG0237	dephospho-CoA kinase activity
CDC59_RS03220	COG1459	type II secretion system
CDC59_RS03230	COG4536	flavin adenine dinucleotide binding
CDC59_RS03240	COG0142	geranyltranstransferase activity
CDC59_RS03245	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CDC59_RS03250	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CDC59_RS03255	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CDC59_RS03260	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CDC59_RS03270	COG0494	nUDIX hydrolase
CDC59_RS03275	COG0442	prolyl-tRNA aminoacylation
CDC59_RS03280	COG0741	lytic transglycosylase activity
CDC59_RS03290	COG2095	MarC family integral membrane protein
CDC59_RS03295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CDC59_RS03300	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CDC59_RS03305	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CDC59_RS03325	COG3023	N-Acetylmuramoyl-L-alanine amidase
CDC59_RS03345	COG5006	permease, DMT superfamily
CDC59_RS03350	COG1522	sequence-specific DNA binding
CDC59_RS03360	COG0840	transmembrane signaling receptor activity
CDC59_RS03400	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC59_RS03405	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CDC59_RS03415	COG2264	protein methyltransferase activity
CDC59_RS03425	COG0511	ligase activity, forming carbon-carbon bonds
CDC59_RS03430	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CDC59_RS03435	COG3118	belongs to the thioredoxin family
CDC59_RS03445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CDC59_RS03450	COG3150	esterase
CDC59_RS03455	COG3161	chorismate lyase activity
CDC59_RS03460	COG0557	exoribonuclease II activity
CDC59_RS03470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CDC59_RS03475	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CDC59_RS03490	COG0284	orotidine-5'-phosphate decarboxylase activity
CDC59_RS03495	COG1230	cation diffusion facilitator family transporter
CDC59_RS03500	COG1546	Belongs to the CinA family
CDC59_RS03505	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CDC59_RS03515	COG0280	phosphate acetyltransferase
CDC59_RS03515	COG0281	malic enzyme
CDC59_RS03535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CDC59_RS03545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CDC59_RS03550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CDC59_RS03555	COG0583	DNA-binding transcription factor activity
CDC59_RS03560	COG0735	belongs to the Fur family
CDC59_RS03565	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CDC59_RS03570	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CDC59_RS03575	COG0495	leucyl-tRNA aminoacylation
CDC59_RS03585	COG1466	dna polymerase III delta subunit
CDC59_RS03590	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CDC59_RS03595	COG1981	membrane
CDC59_RS03605	COG2204	response regulator
CDC59_RS03610	COG4191	Histidine kinase
CDC59_RS03615	COG4191	Histidine kinase
CDC59_RS03640	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CDC59_RS03680	COG0482	sulfurtransferase activity
CDC59_RS03685	COG0069	glutamate synthase activity
CDC59_RS03690	COG0625	glutathione transferase activity
CDC59_RS03700	COG3038	cytochrome b561
CDC59_RS03705	COG2353	YceI-like domain
CDC59_RS03710	COG2353	YceI-like domain
CDC59_RS03715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC59_RS03720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CDC59_RS03725	COG1862	Preprotein translocase
CDC59_RS03730	COG0343	queuine tRNA-ribosyltransferase activity
CDC59_RS03735	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CDC59_RS03740	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CDC59_RS03780	COG1522	sequence-specific DNA binding
CDC59_RS03785	COG1473	amidohydrolase
CDC59_RS03795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS03800	COG2271	Major facilitator Superfamily
CDC59_RS03805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS03810	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS03815	COG0697	spore germination
CDC59_RS03820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS03845	COG0783	Belongs to the Dps family
CDC59_RS03850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC59_RS03910	COG0386	Belongs to the glutathione peroxidase family
CDC59_RS03930	COG1346	cytolysis
CDC59_RS03935	COG1380	Effector of murein hydrolase LrgA
CDC59_RS03940	COG0247	lactate metabolic process
CDC59_RS03945	COG0277	FAD linked oxidase domain protein
CDC59_RS03950	COG0277	FAD linked oxidase domain protein
CDC59_RS03960	COG0277	FAD linked oxidase domain protein
CDC59_RS03965	COG2096	Adenosyltransferase
CDC59_RS03970	COG0668	transmembrane transport
CDC59_RS03980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC59_RS03985	COG0312	modulator of DNA gyrase
CDC59_RS03990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CDC59_RS04000	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
CDC59_RS04015	COG1404	Belongs to the peptidase S8 family
CDC59_RS04025	COG0497	DNA recombination
CDC59_RS04030	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CDC59_RS04035	COG1420	regulation of RNA biosynthetic process
CDC59_RS04045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
CDC59_RS04050	COG2986	histidine ammonia-lyase
CDC59_RS04055	COG0010	Belongs to the arginase family
CDC59_RS04060	COG1228	amidohydrolase
CDC59_RS04065	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CDC59_RS04085	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CDC59_RS04100	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC59_RS04105	COG0443	Heat shock 70 kDa protein
CDC59_RS04110	COG0484	heat shock protein binding
CDC59_RS04115	COG0512	Glutamine amidotransferase of anthranilate synthase
CDC59_RS04115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CDC59_RS04120	COG1122	ATPase activity
CDC59_RS04125	COG4662	Binding-protein-dependent transport system inner membrane component
CDC59_RS04130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CDC59_RS04140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CDC59_RS04145	COG0617	tRNA 3'-terminal CCA addition
CDC59_RS04155	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC59_RS04160	COG0628	permease
CDC59_RS04165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CDC59_RS04180	COG2169	Transcriptional regulator
CDC59_RS04180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC59_RS04200	COG2169	Transcriptional regulator
CDC59_RS04200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC59_RS04210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CDC59_RS04215	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CDC59_RS04220	COG3008	intermembrane lipid transfer
CDC59_RS04235	COG0586	Pfam SNARE associated Golgi protein
CDC59_RS04245	COG0728	peptidoglycan biosynthetic process
CDC59_RS04250	COG0268	Binds directly to 16S ribosomal RNA
CDC59_RS04260	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CDC59_RS04265	COG0137	argininosuccinate synthase activity
CDC59_RS04270	COG3123	guanosine phosphorylase activity
CDC59_RS04295	COG0463	Glycosyl transferase, family 2
CDC59_RS04340	COG4964	Belongs to the GSP D family
CDC59_RS04375	COG1704	LemA family
CDC59_RS04380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS04385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CDC59_RS04390	COG1773	rubredoxin
CDC59_RS04410	COG0840	transmembrane signaling receptor activity
CDC59_RS04415	COG2198	Histidine kinase
CDC59_RS04415	COG0784	Response regulator, receiver
CDC59_RS04415	COG0784	Response regulator, receiver
CDC59_RS04415	COG0643	Histidine kinase
CDC59_RS04415	COG0643	Histidine kinase
CDC59_RS04415	COG2198	Histidine kinase
CDC59_RS04420	COG0415	Belongs to the DNA photolyase family
CDC59_RS04425	COG1187	pseudouridine synthase activity
CDC59_RS04430	COG1678	Uncharacterized ACR, COG1678
CDC59_RS04435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CDC59_RS04440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CDC59_RS04445	COG0540	Belongs to the ATCase OTCase family
CDC59_RS04460	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CDC59_RS04510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC59_RS04515	COG0859	PFAM glycosyl transferase family 9
CDC59_RS04535	COG0425	Belongs to the sulfur carrier protein TusA family
CDC59_RS04535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CDC59_RS04540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC59_RS04565	COG1968	undecaprenyl-diphosphatase activity
CDC59_RS04570	COG1902	pentaerythritol trinitrate reductase activity
CDC59_RS04575	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CDC59_RS04610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CDC59_RS04620	COG0436	Aminotransferase
CDC59_RS04625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC59_RS04630	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CDC59_RS04645	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC59_RS04645	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC59_RS04710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CDC59_RS04715	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CDC59_RS04720	COG4221	oxidoreductase activity
CDC59_RS04725	COG0824	Thioesterase
CDC59_RS04745	COG0823	Involved in the tonB-independent uptake of proteins
CDC59_RS04755	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
CDC59_RS04760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CDC59_RS04765	COG2391	methyltransferase activity
CDC59_RS04775	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
CDC59_RS04800	COG2175	clavaminate synthase activity
CDC59_RS04805	COG0494	nUDIX hydrolase
CDC59_RS04810	COG0390	transport system, permease component
CDC59_RS04815	COG1136	(ABC) transporter
CDC59_RS04835	COG4575	ribosome binding
CDC59_RS04840	COG0450	alkyl hydroperoxide reductase
CDC59_RS04845	COG2252	PERMEase
CDC59_RS04850	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS04860	COG3483	tryptophan 2,3-dioxygenase activity
CDC59_RS04870	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC59_RS04875	COG1522	sequence-specific DNA binding
CDC59_RS04890	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC59_RS04900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC59_RS04905	COG0259	pyridoxamine-phosphate oxidase activity
CDC59_RS04930	COG2982	Protein involved in outer membrane biogenesis
CDC59_RS04935	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CDC59_RS04940	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
CDC59_RS04945	COG2703	oxygen carrier activity
CDC59_RS04955	COG3118	belongs to the thioredoxin family
CDC59_RS04960	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS04970	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
CDC59_RS04985	COG4681	YaeQ
CDC59_RS05015	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC59_RS05035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC59_RS05040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC59_RS05050	COG4804	nuclease activity
CDC59_RS05065	COG4774	siderophore transport
CDC59_RS05075	COG0330	HflC and HflK could
CDC59_RS05090	COG0477	Major facilitator Superfamily
CDC59_RS05095	COG0235	Class ii aldolase
CDC59_RS05100	COG1942	4-Oxalocrotonate Tautomerase
CDC59_RS05115	COG0425	Belongs to the sulfur carrier protein TusA family
CDC59_RS05130	COG1280	lysine exporter protein (LysE YggA)
CDC59_RS05145	COG1733	regulation of RNA biosynthetic process
CDC59_RS05155	COG4305	rare lipoprotein A
CDC59_RS05175	COG4383	Mu-like prophage protein gp29
CDC59_RS05200	COG1196	nuclear chromosome segregation
CDC59_RS05200	COG0739	heme binding
CDC59_RS05200	COG0741	lytic transglycosylase activity
CDC59_RS05260	COG0776	regulation of translation
CDC59_RS05295	COG4388	Caudovirus prohead serine protease
CDC59_RS05300	COG4397	Mu-like prophage major head subunit gpT
CDC59_RS05320	COG4386	tail sheath protein
CDC59_RS05385	COG1741	Belongs to the pirin family
CDC59_RS05390	COG1902	pentaerythritol trinitrate reductase activity
CDC59_RS05405	COG0640	Transcriptional regulator
CDC59_RS05435	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CDC59_RS05460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CDC59_RS05470	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CDC59_RS05475	COG0287	Prephenate dehydrogenase
CDC59_RS05480	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CDC59_RS05485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CDC59_RS05495	COG0776	regulation of translation
CDC59_RS05505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
CDC59_RS05515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CDC59_RS05520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC59_RS05535	COG2951	lytic endotransglycosylase activity
CDC59_RS05540	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC59_RS05560	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CDC59_RS05600	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC59_RS05605	COG1061	Type III restriction enzyme res subunit
CDC59_RS05610	COG1002	Type II restriction enzyme, methylase subunits
CDC59_RS05625	COG0582	viral genome integration into host DNA
CDC59_RS05635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CDC59_RS05645	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
CDC59_RS05735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS05750	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC59_RS05760	COG0194	GDP metabolic process
CDC59_RS05765	COG0159	tryptophan synthase activity
CDC59_RS05770	COG0133	tryptophan synthase activity
CDC59_RS05795	COG2249	NAD(P)H dehydrogenase (quinone) activity
CDC59_RS05805	COG0583	DNA-binding transcription factor activity
CDC59_RS05850	COG3713	MltA-interacting MipA family protein
CDC59_RS05875	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC59_RS05880	COG1253	flavin adenine dinucleotide binding
CDC59_RS05920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS05935	COG0765	amino acid transport
CDC59_RS05940	COG0765	amino acid transport
CDC59_RS05945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS05955	COG1414	Transcriptional regulator
CDC59_RS05965	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
CDC59_RS05970	COG0183	Belongs to the thiolase family
CDC59_RS05980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC59_RS05985	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC59_RS06000	COG0411	ABC transporter
CDC59_RS06010	COG0683	leucine binding
CDC59_RS06025	COG2342	PFAM TM1410 hypothetical-related protein
CDC59_RS06035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC59_RS06050	COG0525	valine-tRNA ligase activity
CDC59_RS06055	COG0210	DNA helicase
CDC59_RS06065	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
CDC59_RS06075	COG1611	Belongs to the LOG family
CDC59_RS06080	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC59_RS06080	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CDC59_RS06085	COG1252	NADH dehydrogenase
CDC59_RS06090	COG0412	Dienelactone hydrolase
CDC59_RS06115	COG1722	exodeoxyribonuclease VII activity
CDC59_RS06120	COG0142	geranyltranstransferase activity
CDC59_RS06125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CDC59_RS06130	COG1469	GTP cyclohydrolase I activity
CDC59_RS06135	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CDC59_RS06140	COG2081	HI0933 family
CDC59_RS06145	COG1610	YqeY-like protein
CDC59_RS06165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CDC59_RS06175	COG0426	domain, Protein
CDC59_RS06175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC59_RS06180	COG0513	Belongs to the DEAD box helicase family
CDC59_RS06185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC59_RS06190	COG0583	DNA-binding transcription factor activity
CDC59_RS06195	COG1741	Belongs to the pirin family
CDC59_RS06205	COG1054	Belongs to the UPF0176 family
CDC59_RS06235	COG1132	(ABC) transporter
CDC59_RS06250	COG1530	ribonuclease E activity
CDC59_RS06255	COG0424	maF-like protein
CDC59_RS06260	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CDC59_RS06265	COG0799	negative regulation of ribosome biogenesis
CDC59_RS06275	COG0408	coproporphyrinogen oxidase activity
CDC59_RS06280	COG0151	Belongs to the GarS family
CDC59_RS06285	COG0217	transcriptional regulatory protein
CDC59_RS06290	COG0433	COG0433 Predicted ATPase
CDC59_RS06295	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CDC59_RS06300	COG0697	spore germination
CDC59_RS06305	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS06310	COG1803	Methylglyoxal synthase
CDC59_RS06360	COG4603	Belongs to the binding-protein-dependent transport system permease family
CDC59_RS06365	COG3845	ABC transporter
CDC59_RS06370	COG2814	Major facilitator Superfamily
CDC59_RS06375	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC59_RS06380	COG1984	allophanate hydrolase subunit 2
CDC59_RS06385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC59_RS06400	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CDC59_RS06405	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC59_RS06420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CDC59_RS06425	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CDC59_RS06430	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CDC59_RS06440	COG0515	serine threonine protein kinase
CDC59_RS06440	COG3064	Membrane
CDC59_RS06440	COG4991	sh3 domain protein
CDC59_RS06445	COG1561	YicC-like family, N-terminal region
CDC59_RS06450	COG0194	GDP metabolic process
CDC59_RS06455	COG1758	RNA polymerase activity
CDC59_RS06465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC59_RS06495	COG1652	LysM domain
CDC59_RS06505	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CDC59_RS06510	COG0308	aminopeptidase N
CDC59_RS06520	COG0281	malic enzyme
CDC59_RS06520	COG0280	phosphate acetyltransferase
CDC59_RS06530	COG3195	allantoin biosynthetic process
CDC59_RS06530	COG3648	Uricase
CDC59_RS06545	COG2233	PERMEase
CDC59_RS06555	COG2351	hydroxyisourate hydrolase activity
CDC59_RS06575	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
CDC59_RS06590	COG1064	alcohol dehydrogenase
CDC59_RS06605	COG0583	DNA-binding transcription factor activity
CDC59_RS06620	COG2119	membrane
CDC59_RS06625	COG0402	S-adenosylhomocysteine deaminase activity
CDC59_RS06630	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
CDC59_RS06640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CDC59_RS06655	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CDC59_RS06660	COG2011	ABC-type metal ion transport system permease component
CDC59_RS06680	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS06720	COG0228	four-way junction DNA binding
CDC59_RS06725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CDC59_RS06730	COG0336	Belongs to the RNA methyltransferase TrmD family
CDC59_RS06735	COG0335	large ribosomal subunit rRNA binding
CDC59_RS06745	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC59_RS06755	COG1162	GTPase activity
CDC59_RS06765	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
CDC59_RS06770	COG0521	Mo-molybdopterin cofactor biosynthetic process
CDC59_RS06775	COG3028	Belongs to the UPF0307 family
CDC59_RS06780	COG0312	modulator of DNA gyrase
CDC59_RS06790	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDC59_RS06800	COG0861	Integral membrane protein TerC family
CDC59_RS06810	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC59_RS06815	COG0513	Belongs to the DEAD box helicase family
CDC59_RS06880	COG0582	viral genome integration into host DNA
CDC59_RS06905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS06915	COG0488	(ABC) transporter
CDC59_RS06955	COG1620	l-lactate permease
CDC59_RS06975	COG0625	glutathione transferase activity
CDC59_RS06980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC59_RS06990	COG0697	spore germination
CDC59_RS06995	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CDC59_RS07000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC59_RS07005	COG0326	Molecular chaperone. Has ATPase activity
CDC59_RS07075	COG0778	Nitroreductase
CDC59_RS07080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CDC59_RS07085	COG2878	Part of a membrane complex involved in electron transport
CDC59_RS07090	COG1309	transcriptional regulator
CDC59_RS07105	COG0556	nucleotide-excision repair
CDC59_RS07115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC59_RS07120	COG1609	Transcriptional regulator
CDC59_RS07125	COG1172	Belongs to the binding-protein-dependent transport system permease family
CDC59_RS07130	COG1129	ABC transporter
CDC59_RS07145	COG1104	cysteine desulfurase activity
CDC59_RS07150	COG0822	iron-sulfur transferase activity
CDC59_RS07165	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CDC59_RS07170	COG0443	Heat shock 70 kDa protein
CDC59_RS07175	COG0633	Ferredoxin
CDC59_RS07190	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CDC59_RS07195	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS07205	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CDC59_RS07240	COG0746	molybdenum cofactor guanylyltransferase activity
CDC59_RS07245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CDC59_RS07250	COG1530	ribonuclease E activity
CDC59_RS07260	COG0546	phosphoglycolate phosphatase activity
CDC59_RS07270	COG0616	signal peptide processing
CDC59_RS07270	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CDC59_RS07280	COG0424	maF-like protein
CDC59_RS07285	COG1399	metal-binding, possibly nucleic acid-binding protein
CDC59_RS07290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CDC59_RS07295	COG0416	fatty acid biosynthetic process
CDC59_RS07300	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CDC59_RS07310	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CDC59_RS07320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC59_RS07345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC59_RS07355	COG0481	GTPase activity
CDC59_RS07360	COG0681	Belongs to the peptidase S26 family
CDC59_RS07370	COG0571	ribonuclease III activity
CDC59_RS07375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CDC59_RS07380	COG1381	Involved in DNA repair and RecF pathway recombination
CDC59_RS07385	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CDC59_RS07390	COG0736	holo-[acyl-carrier-protein] synthase activity
CDC59_RS07400	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CDC59_RS07410	COG0322	excinuclease ABC activity
CDC59_RS07435	COG0745	RESPONSE REGULATOR receiver
CDC59_RS07445	COG5002	protein histidine kinase activity
CDC59_RS07450	COG0745	RESPONSE REGULATOR receiver
CDC59_RS07460	COG2186	Transcriptional regulator
CDC59_RS07470	COG2271	Major facilitator Superfamily
CDC59_RS07480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS07490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS07540	COG0583	DNA-binding transcription factor activity
CDC59_RS07560	COG2124	cytochrome p450
CDC59_RS07585	COG0583	DNA-binding transcription factor activity
CDC59_RS07590	COG2855	membrane
CDC59_RS07615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC59_RS07620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CDC59_RS07635	COG1136	(ABC) transporter
CDC59_RS07640	COG0084	hydrolase, TatD family'
CDC59_RS07650	COG2308	Evidence 4 Homologs of previously reported genes of
CDC59_RS07670	COG2267	carboxylic ester hydrolase activity
CDC59_RS07675	COG0504	CTP synthase activity
CDC59_RS07680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CDC59_RS07690	COG0148	phosphopyruvate hydratase activity
CDC59_RS07695	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
CDC59_RS07705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CDC59_RS07715	COG2833	Protein of unknown function (DUF455)
CDC59_RS07720	COG2267	carboxylic ester hydrolase activity
CDC59_RS07725	COG3011	Protein conserved in bacteria
CDC59_RS07740	COG0492	ferredoxin-NADP+ reductase activity
CDC59_RS07745	COG0613	PHP domain protein
CDC59_RS07750	COG0009	L-threonylcarbamoyladenylate synthase
CDC59_RS07755	COG1994	Peptidase M50
CDC59_RS07760	COG0180	Tryptophanyl-tRNA synthetase
CDC59_RS07765	COG2226	methyltransferase
CDC59_RS07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS07775	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
CDC59_RS07780	COG0321	lipoyl(octanoyl) transferase activity
CDC59_RS07780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CDC59_RS07790	COG2850	peptidyl-arginine hydroxylation
CDC59_RS07805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CDC59_RS07810	COG0583	DNA-binding transcription factor activity
CDC59_RS07815	COG2814	Major facilitator Superfamily
CDC59_RS07820	COG0656	L-ascorbic acid biosynthetic process
CDC59_RS07835	COG2258	MOSC domain
CDC59_RS07845	COG1396	sequence-specific DNA binding
CDC59_RS07850	COG0483	inositol monophosphate 1-phosphatase activity
CDC59_RS07860	COG1045	serine acetyltransferase
CDC59_RS07865	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC59_RS07885	COG0215	cysteine-tRNA ligase activity
CDC59_RS07890	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CDC59_RS07895	COG0825	malonyl-CoA metabolic process
CDC59_RS07900	COG0037	tRNA processing
CDC59_RS07905	COG0527	aspartate kinase activity
CDC59_RS07920	COG4166	transmembrane transport
CDC59_RS07925	COG4174	ABC transporter (Permease)
CDC59_RS07930	COG4239	(ABC) transporter, permease
CDC59_RS07935	COG4172	Belongs to the ABC transporter superfamily
CDC59_RS07940	COG0791	NLP P60 protein
CDC59_RS07945	COG1752	Esterase of the alpha-beta hydrolase superfamily
CDC59_RS07950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CDC59_RS07985	COG0534	Mate efflux family protein
CDC59_RS07995	COG0254	rRNA binding
CDC59_RS08000	COG3228	Belongs to the MtfA family
CDC59_RS08005	COG2197	response regulator
CDC59_RS08010	COG2204	response regulator
CDC59_RS08015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CDC59_RS08030	COG1074	ATP-dependent DNA helicase activity
CDC59_RS08045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CDC59_RS08050	COG2329	Antibiotic biosynthesis monooxygenase
CDC59_RS08055	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CDC59_RS08070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC59_RS08075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC59_RS08085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC59_RS08090	COG1309	transcriptional regulator
CDC59_RS08095	COG1902	pentaerythritol trinitrate reductase activity
CDC59_RS08105	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CDC59_RS08110	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CDC59_RS08130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CDC59_RS08135	COG0670	Belongs to the BI1 family
CDC59_RS08140	COG0105	UTP biosynthetic process
CDC59_RS08145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CDC59_RS08160	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CDC59_RS08165	COG0124	histidyl-tRNA synthetase
CDC59_RS08170	COG2976	Protein conserved in bacteria
CDC59_RS08180	COG1160	GTP binding
CDC59_RS08185	COG1923	regulation of RNA biosynthetic process
CDC59_RS08190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CDC59_RS08195	COG0330	HflC and HflK could
CDC59_RS08200	COG0330	HflC and HflK could
CDC59_RS08210	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CDC59_RS08215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CDC59_RS08220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CDC59_RS08230	COG0557	exoribonuclease II activity
CDC59_RS08235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC59_RS08240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CDC59_RS08245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CDC59_RS08250	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CDC59_RS08255	COG1953	Uracil, thiamine, allantoin
CDC59_RS08265	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
CDC59_RS08270	COG0673	inositol 2-dehydrogenase activity
CDC59_RS08275	COG1737	Transcriptional regulator
CDC59_RS08300	COG3657	addiction module killer protein
CDC59_RS08325	COG1129	ABC transporter
CDC59_RS08330	COG4211	Belongs to the binding-protein-dependent transport system permease family
CDC59_RS08340	COG3962	Belongs to the TPP enzyme family
CDC59_RS08350	COG3718	enzyme involved in inositol metabolism
CDC59_RS08360	COG0673	inositol 2-dehydrogenase activity
CDC59_RS08365	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
CDC59_RS08365	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CDC59_RS08370	COG1643	Atp-dependent helicase
CDC59_RS08395	COG1546	Belongs to the CinA family
CDC59_RS08395	COG1058	Belongs to the CinA family
CDC59_RS08405	COG0174	glutamine synthetase
CDC59_RS08420	COG2204	response regulator
CDC59_RS08430	COG2217	Heavy metal translocating P-type atpase
CDC59_RS08435	COG1653	transport
CDC59_RS08450	COG0395	ABC-type sugar transport system, permease component
CDC59_RS08455	COG3842	ATPase activity
CDC59_RS08460	COG0584	glycerophosphoryl diester phosphodiesterase
CDC59_RS08465	COG0567	Dehydrogenase, E1 component
CDC59_RS08470	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC59_RS08475	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC59_RS08480	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
CDC59_RS08490	COG2217	Heavy metal translocating P-type atpase
CDC59_RS08500	COG3278	Belongs to the heme-copper respiratory oxidase family
CDC59_RS08535	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC59_RS08545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CDC59_RS08555	COG0779	Required for maturation of 30S ribosomal subunits
CDC59_RS08560	COG2251	uridine kinase activity
CDC59_RS08560	COG0195	Participates in both transcription termination and antitermination
CDC59_RS08565	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CDC59_RS08570	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CDC59_RS08575	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CDC59_RS08580	COG2814	Major facilitator Superfamily
CDC59_RS08585	COG1566	PFAM secretion protein HlyD family protein
CDC59_RS08595	COG1846	Transcriptional regulator
CDC59_RS08600	COG1217	gtp-binding protein TYPA
CDC59_RS08610	COG1024	Enoyl-CoA hydratase
CDC59_RS08615	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC59_RS08630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC59_RS08650	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CDC59_RS08665	COG0360	Binds together with S18 to 16S ribosomal RNA
CDC59_RS08675	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CDC59_RS08680	COG0359	binds to the 23S rRNA
CDC59_RS08685	COG0305	Participates in initiation and elongation during chromosome replication
CDC59_RS08695	COG0306	phosphate transporter
CDC59_RS08700	COG0791	NLP P60 protein
CDC59_RS08710	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CDC59_RS08715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CDC59_RS08720	COG0726	polysaccharide deacetylase
CDC59_RS08725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC59_RS08725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC59_RS08740	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC59_RS08745	COG2076	Multidrug Resistance protein
CDC59_RS08750	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDC59_RS08760	COG0436	Aminotransferase
CDC59_RS08775	COG1573	uracil-dna glycosylase
CDC59_RS08780	COG0303	'Molybdopterin
CDC59_RS08785	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
CDC59_RS08790	COG0314	molybdopterin synthase activity
CDC59_RS08795	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CDC59_RS08805	COG0542	response to heat
CDC59_RS08810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CDC59_RS08815	COG0431	NADPH-dependent FMN reductase
CDC59_RS08820	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC59_RS08825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC59_RS08830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC59_RS08835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC59_RS08840	COG1116	anion transmembrane transporter activity
CDC59_RS08860	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
CDC59_RS08865	COG4208	sulfate ABC transporter
CDC59_RS08870	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC59_RS08875	COG0583	DNA-binding transcription factor activity
CDC59_RS08890	COG3275	phosphorelay sensor kinase activity
CDC59_RS08905	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC59_RS08925	COG2224	Isocitrate lyase
CDC59_RS08935	COG0583	DNA-binding transcription factor activity
CDC59_RS08945	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
CDC59_RS08960	COG1214	PFAM Peptidase M22, glycoprotease
CDC59_RS08965	COG0456	acetyltransferase
CDC59_RS08970	COG1573	uracil-dna glycosylase
CDC59_RS08975	COG0477	Major facilitator Superfamily
CDC59_RS08980	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CDC59_RS08990	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC59_RS08995	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC59_RS09000	COG0488	(ABC) transporter
CDC59_RS09010	COG1446	asparaginase
CDC59_RS09015	COG4172	Belongs to the ABC transporter superfamily
CDC59_RS09020	COG0747	negative chemotaxis
CDC59_RS09030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC59_RS09065	COG2890	protein-(glutamine-N5) methyltransferase activity
CDC59_RS09075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC59_RS09080	COG1393	Belongs to the ArsC family
CDC59_RS09090	COG2171	N-acyltransferase activity
CDC59_RS09105	COG0596	Alpha beta hydrolase
CDC59_RS09120	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CDC59_RS09125	COG0242	peptide deformylase activity
CDC59_RS09135	COG1187	pseudouridine synthase activity
CDC59_RS09140	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CDC59_RS09145	COG0024	Methionine aminopeptidase
CDC59_RS09150	COG0052	Belongs to the universal ribosomal protein uS2 family
CDC59_RS09155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CDC59_RS09160	COG0528	UMP kinase activity
CDC59_RS09165	COG0233	cytoplasmic translational termination
CDC59_RS09170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CDC59_RS09175	COG0575	Belongs to the CDS family
CDC59_RS09180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CDC59_RS09185	COG0750	zinc metalloprotease
CDC59_RS09200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC59_RS09205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC59_RS09210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC59_RS09215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CDC59_RS09220	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CDC59_RS09225	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CDC59_RS09245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CDC59_RS09260	COG0330	HflC and HflK could
CDC59_RS09265	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CDC59_RS09270	COG2867	negative regulation of translational initiation
CDC59_RS09275	COG2914	Belongs to the UPF0125 (RnfH) family
CDC59_RS09285	COG0697	spore germination
CDC59_RS09300	COG0519	Catalyzes the synthesis of GMP from XMP
CDC59_RS09300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CDC59_RS09340	COG0583	DNA-binding transcription factor activity
CDC59_RS09345	COG3485	protocatechuate 3,4-dioxygenase
CDC59_RS09350	COG3485	protocatechuate 3,4-dioxygenase
CDC59_RS09375	COG0583	DNA-binding transcription factor activity
CDC59_RS09385	COG3550	peptidyl-serine autophosphorylation
CDC59_RS09395	COG0602	queuosine metabolic process
CDC59_RS09400	COG0720	synthase
CDC59_RS09410	COG1619	proteins homologs of microcin C7 resistance protein MccF
CDC59_RS09415	COG0488	(ABC) transporter
CDC59_RS09445	COG3387	PFAM Glycoside hydrolase 15-related
CDC59_RS09455	COG0840	transmembrane signaling receptor activity
CDC59_RS09465	COG3320	Male sterility
CDC59_RS09465	COG1022	Amp-dependent synthetase and ligase
CDC59_RS09470	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CDC59_RS09505	COG3045	CreA protein
CDC59_RS09510	COG0583	DNA-binding transcription factor activity
CDC59_RS09535	COG0778	Nitroreductase
CDC59_RS09550	COG0583	DNA-binding transcription factor activity
CDC59_RS09555	COG4948	Mandelate Racemase Muconate Lactonizing
CDC59_RS09570	COG4638	Rieske (2fe-2S)
CDC59_RS09575	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
CDC59_RS09580	COG0543	2 iron, 2 sulfur cluster binding
CDC59_RS09580	COG0633	Ferredoxin
CDC59_RS09585	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS09595	COG0156	8-amino-7-oxononanoate synthase activity
CDC59_RS09600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CDC59_RS09615	COG3739	integral membrane protein
CDC59_RS09640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CDC59_RS09670	COG1196	nuclear chromosome segregation
CDC59_RS09700	COG0833	amino acid
CDC59_RS09705	COG0833	amino acid
CDC59_RS09715	COG1335	isochorismatase
CDC59_RS09720	COG0183	Belongs to the thiolase family
CDC59_RS09725	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS09745	COG2130	NADP-dependent
CDC59_RS09765	COG0596	Alpha beta hydrolase
CDC59_RS09775	COG0657	acetylesterase activity
CDC59_RS09810	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CDC59_RS09815	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CDC59_RS09820	COG0470	DNA polymerase III
CDC59_RS09830	COG0084	hydrolase, TatD family'
CDC59_RS09845	COG1262	PFAM Formylglycine-generating sulfatase enzyme
CDC59_RS09850	COG1609	Transcriptional regulator
CDC59_RS09855	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC59_RS09865	COG4208	sulfate ABC transporter
CDC59_RS09870	COG3842	ATPase activity
CDC59_RS09875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC59_RS10000	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS10005	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CDC59_RS10010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CDC59_RS10015	COG2917	probably involved in intracellular septation
CDC59_RS10025	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC59_RS10040	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CDC59_RS10055	COG0642	Histidine kinase
CDC59_RS10060	COG3842	ATPase activity
CDC59_RS10070	COG1176	ABC-type spermidine putrescine transport system, permease component I
CDC59_RS10075	COG1177	transmembrane transport
CDC59_RS10080	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS10085	COG0583	DNA-binding transcription factor activity
CDC59_RS10090	COG0535	radical SAM domain protein
CDC59_RS10115	COG0047	phosphoribosylformylglycinamidine synthase activity
CDC59_RS10115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CDC59_RS10125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CDC59_RS10130	COG0166	Belongs to the GPI family
CDC59_RS10135	COG4181	ATPase activity
CDC59_RS10145	COG0681	Belongs to the peptidase S26 family
CDC59_RS10150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC59_RS10165	COG0776	regulation of translation
CDC59_RS10170	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CDC59_RS10175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CDC59_RS10180	COG0740	serine-type endopeptidase activity
CDC59_RS10185	COG0544	peptidyl-prolyl cis-trans isomerase activity
CDC59_RS10190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS10190	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC59_RS10215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS10250	COG0450	alkyl hydroperoxide reductase
CDC59_RS10255	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC59_RS10260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CDC59_RS10265	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CDC59_RS10270	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CDC59_RS10280	COG0560	Phosphoserine phosphatase
CDC59_RS10285	COG4804	nuclease activity
CDC59_RS10290	COG0626	cystathionine gamma-synthase activity
CDC59_RS10300	COG0183	Belongs to the thiolase family
CDC59_RS10305	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC59_RS10310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CDC59_RS10320	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS10325	COG0183	Belongs to the thiolase family
CDC59_RS10330	COG3243	poly(R)-hydroxyalkanoic acid synthase
CDC59_RS10345	COG0564	pseudouridine synthase activity
CDC59_RS10355	COG1199	ATP-dependent helicase activity
CDC59_RS10370	COG2183	response to ionizing radiation
CDC59_RS10385	COG3158	transport of potassium into the cell
CDC59_RS10395	COG0167	dihydroorotate dehydrogenase activity
CDC59_RS10410	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CDC59_RS10415	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CDC59_RS10440	COG1414	Transcriptional regulator
CDC59_RS10455	COG0824	Thioesterase
CDC59_RS10465	COG0123	including yeast histone deacetylase and acetoin utilization protein
CDC59_RS10480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CDC59_RS10490	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC59_RS10495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CDC59_RS10510	COG4566	intracellular signal transduction
CDC59_RS10515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CDC59_RS10520	COG0339	signal peptide processing
CDC59_RS10525	COG0402	S-adenosylhomocysteine deaminase activity
CDC59_RS10535	COG1846	Transcriptional regulator
CDC59_RS10555	COG0531	amino acid
CDC59_RS10560	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CDC59_RS10580	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC59_RS10585	COG2207	Transcriptional regulator
CDC59_RS10680	COG0776	regulation of translation
CDC59_RS10685	COG0072	phenylalanine-tRNA ligase activity
CDC59_RS10685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC59_RS10690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CDC59_RS10695	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CDC59_RS10700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CDC59_RS10705	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CDC59_RS10710	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CDC59_RS10720	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CDC59_RS10725	COG0251	oxidation-reduction process
CDC59_RS10735	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS10750	COG4566	intracellular signal transduction
CDC59_RS10755	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS10765	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CDC59_RS10770	COG0545	Peptidyl-prolyl cis-trans isomerase
CDC59_RS10775	COG0477	Major facilitator Superfamily
CDC59_RS10790	COG2267	carboxylic ester hydrolase activity
CDC59_RS10800	COG1295	ribonuclease BN
CDC59_RS10815	COG0277	FAD linked oxidase domain protein
CDC59_RS10885	COG0248	Ppx GppA phosphatase
CDC59_RS10900	COG0745	RESPONSE REGULATOR receiver
CDC59_RS10910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CDC59_RS10915	COG0581	inorganic phosphate transmembrane transporter activity
CDC59_RS10920	COG0573	inorganic phosphate transmembrane transporter activity
CDC59_RS10925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CDC59_RS10930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CDC59_RS10935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CDC59_RS10940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CDC59_RS10945	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
CDC59_RS10950	COG1534	Rna-binding protein
CDC59_RS10960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CDC59_RS10965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CDC59_RS10975	COG0505	Belongs to the CarA family
CDC59_RS10980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC59_RS10985	COG0741	lytic transglycosylase activity
CDC59_RS10985	COG1388	LysM domain
CDC59_RS10990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CDC59_RS10995	COG2226	methyltransferase
CDC59_RS11000	COG0328	RNA-DNA hybrid ribonuclease activity
CDC59_RS11035	COG0589	response to stress
CDC59_RS11050	COG2304	oxidoreductase activity
CDC59_RS11110	COG0582	viral genome integration into host DNA
CDC59_RS11120	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CDC59_RS11165	COG2072	flavoprotein involved in K transport
CDC59_RS11170	COG0601	transmembrane transport
CDC59_RS11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC59_RS11180	COG0444	Belongs to the ABC transporter superfamily
CDC59_RS11185	COG4608	Belongs to the ABC transporter superfamily
CDC59_RS11190	COG0747	negative chemotaxis
CDC59_RS11230	COG0840	transmembrane signaling receptor activity
CDC59_RS11240	COG2197	response regulator
CDC59_RS11270	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CDC59_RS11275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC59_RS11280	COG0697	spore germination
CDC59_RS11295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CDC59_RS11300	COG1301	dicarboxylic acid transport
CDC59_RS11340	COG3193	protein, possibly involved in utilization of glycolate and propanediol
CDC59_RS11370	COG1131	(ABC) transporter
CDC59_RS11375	COG0842	Transport permease protein
CDC59_RS11395	COG0285	dihydrofolate synthase activity
CDC59_RS11400	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CDC59_RS11405	COG0159	tryptophan synthase activity
CDC59_RS11415	COG0133	tryptophan synthase activity
CDC59_RS11420	COG0135	phosphoribosylanthranilate isomerase activity
CDC59_RS11425	COG0101	tRNA pseudouridine synthase activity
CDC59_RS11440	COG0473	3-isopropylmalate dehydrogenase activity
CDC59_RS11445	COG0066	3-isopropylmalate dehydratase activity
CDC59_RS11450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CDC59_RS11455	COG0372	Belongs to the citrate synthase family
CDC59_RS11460	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
CDC59_RS11465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CDC59_RS11470	COG1053	succinate dehydrogenase
CDC59_RS11475	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
CDC59_RS11485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC59_RS11490	COG0039	L-malate dehydrogenase activity
CDC59_RS11520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
CDC59_RS11535	COG0747	negative chemotaxis
CDC59_RS11545	COG2866	Carboxypeptidase
CDC59_RS11550	COG3022	response to hydroperoxide
CDC59_RS11560	COG0436	Aminotransferase
CDC59_RS11565	COG0625	glutathione transferase activity
CDC59_RS11570	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC59_RS11575	COG1024	Enoyl-CoA hydratase
CDC59_RS11595	COG0583	DNA-binding transcription factor activity
CDC59_RS11610	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS11615	COG0625	glutathione transferase activity
CDC59_RS11640	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CDC59_RS11645	COG0830	nickel cation binding
CDC59_RS11650	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CDC59_RS11660	COG0832	Belongs to the urease beta subunit family
CDC59_RS11670	COG0831	urea catabolic process
CDC59_RS11680	COG0829	nickel cation binding
CDC59_RS11715	COG2030	dehydratase
CDC59_RS11715	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS11720	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS11725	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS11745	COG1007	ATP synthesis coupled electron transport
CDC59_RS11760	COG0713	ATP synthesis coupled electron transport
CDC59_RS11770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC59_RS11775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CDC59_RS11780	COG1034	ATP synthesis coupled electron transport
CDC59_RS11795	COG0649	NAD binding
CDC59_RS11800	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC59_RS11805	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC59_RS11810	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CDC59_RS11825	COG0149	triose-phosphate isomerase activity
CDC59_RS11830	COG1063	alcohol dehydrogenase
CDC59_RS11840	COG1185	polyribonucleotide nucleotidyltransferase activity
CDC59_RS11845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CDC59_RS11850	COG0683	leucine binding
CDC59_RS11860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC59_RS11865	COG1183	phosphatidylcholine synthase activity
CDC59_RS11870	COG0688	phosphatidylethanolamine metabolic process
CDC59_RS11875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CDC59_RS11885	COG0028	Belongs to the TPP enzyme family
CDC59_RS11920	COG0438	transferase activity, transferring glycosyl groups
CDC59_RS11930	COG1309	transcriptional regulator
CDC59_RS11955	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
CDC59_RS12045	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDC59_RS12050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CDC59_RS12060	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CDC59_RS12065	COG1674	ftsk spoiiie
CDC59_RS12070	COG0492	ferredoxin-NADP+ reductase activity
CDC59_RS12080	COG2860	membrane
CDC59_RS12090	COG2226	methyltransferase
CDC59_RS12110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CDC59_RS12125	COG2271	Major facilitator Superfamily
CDC59_RS12150	COG0181	hydroxymethylbilane synthase activity
CDC59_RS12155	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
CDC59_RS12185	COG0165	Argininosuccinate lyase
CDC59_RS12195	COG0717	Belongs to the dCTP deaminase family
CDC59_RS12200	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC59_RS12205	COG2032	superoxide dismutase activity
CDC59_RS12225	COG0437	4 iron, 4 sulfur cluster binding
CDC59_RS12260	COG0489	protein tyrosine kinase activity
CDC59_RS12265	COG2885	chlorophyll binding
CDC59_RS12265	COG3047	cAMP biosynthetic process
CDC59_RS12270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC59_RS12270	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CDC59_RS12280	COG2911	Protein conserved in bacteria
CDC59_RS12295	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CDC59_RS12300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CDC59_RS12310	COG1492	cobalamin metabolic process
CDC59_RS12320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CDC59_RS12330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CDC59_RS12340	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CDC59_RS12345	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CDC59_RS12355	COG1120	ATPase activity
CDC59_RS12365	COG4206	TonB-dependent receptor
CDC59_RS12390	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CDC59_RS12395	COG0583	DNA-binding transcription factor activity
CDC59_RS12400	COG0129	dihydroxy-acid dehydratase activity
CDC59_RS12415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CDC59_RS12440	COG1648	precorrin-2 dehydrogenase activity
CDC59_RS12440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC59_RS12445	COG2895	sulfate adenylyltransferase (ATP) activity
CDC59_RS12455	COG0175	sulfate reduction
CDC59_RS12465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC59_RS12470	COG0730	response to heat
CDC59_RS12475	COG0583	DNA-binding transcription factor activity
CDC59_RS12485	COG2084	Dehydrogenase
CDC59_RS12520	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC59_RS12555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CDC59_RS12560	COG1047	Peptidyl-prolyl cis-trans
CDC59_RS12565	COG2003	Belongs to the UPF0758 family
CDC59_RS12570	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CDC59_RS12575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CDC59_RS12580	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC59_RS12590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CDC59_RS12605	COG3264	Mechanosensitive ion channel
CDC59_RS12605	COG1511	domain protein
CDC59_RS12615	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CDC59_RS12615	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC59_RS12620	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CDC59_RS12625	COG2197	response regulator
CDC59_RS12630	COG5002	protein histidine kinase activity
CDC59_RS12630	COG0784	Response regulator, receiver
CDC59_RS12635	COG0196	riboflavin kinase activity
CDC59_RS12640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CDC59_RS12645	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CDC59_RS12655	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CDC59_RS12660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC59_RS12665	COG0756	dUTP diphosphatase activity
CDC59_RS12670	COG0542	response to heat
CDC59_RS12675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CDC59_RS12680	COG1278	Cold shock
CDC59_RS12735	COG1858	cytochrome C peroxidase
CDC59_RS12755	COG0583	DNA-binding transcription factor activity
CDC59_RS12765	COG0477	Major facilitator Superfamily
CDC59_RS12770	COG2259	Doxx family
CDC59_RS12785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS12795	COG2321	neutral zinc metallopeptidase
CDC59_RS12800	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS12815	COG0697	spore germination
CDC59_RS12870	COG2610	gluconate transmembrane transporter activity
CDC59_RS12905	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS12910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CDC59_RS12915	COG1570	exodeoxyribonuclease VII activity
CDC59_RS12920	COG0811	peptide transport
CDC59_RS12925	COG0848	biopolymer transport protein
CDC59_RS12930	COG1663	tetraacyldisaccharide 4'-kinase activity
CDC59_RS12935	COG2835	tetraacyldisaccharide 4'-kinase activity
CDC59_RS12940	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CDC59_RS12945	COG0563	adenylate kinase activity
CDC59_RS12955	COG0583	DNA-binding transcription factor activity
CDC59_RS12965	COG0860	N-Acetylmuramoyl-L-alanine amidase
CDC59_RS12970	COG0802	atpase or kinase
CDC59_RS12975	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CDC59_RS12985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CDC59_RS12990	COG4974	Belongs to the 'phage' integrase family
CDC59_RS13000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CDC59_RS13010	COG1666	GTP binding
CDC59_RS13015	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CDC59_RS13045	COG4269	membrane
CDC59_RS13050	COG0459	protein refolding
CDC59_RS13055	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CDC59_RS13065	COG0443	Heat shock 70 kDa protein
CDC59_RS13080	COG2974	May be involved in recombination
CDC59_RS13140	COG4221	oxidoreductase activity
CDC59_RS13160	COG0840	transmembrane signaling receptor activity
CDC59_RS13165	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
CDC59_RS13185	COG2995	paraquat-inducible protein a
CDC59_RS13190	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CDC59_RS13190	COG3008	intermembrane lipid transfer
CDC59_RS13200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC59_RS13265	COG1228	amidohydrolase
CDC59_RS13270	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
CDC59_RS13285	COG0738	Major facilitator superfamily
CDC59_RS13295	COG2027	D-alanyl-D-alanine carboxypeptidase
CDC59_RS13300	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC59_RS13310	COG0546	phosphoglycolate phosphatase activity
CDC59_RS13320	COG0009	L-threonylcarbamoyladenylate synthase
CDC59_RS13325	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CDC59_RS13330	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CDC59_RS13335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CDC59_RS13345	COG0469	pyruvate kinase activity
CDC59_RS13350	COG0126	phosphoglycerate kinase activity
CDC59_RS13380	COG0859	PFAM glycosyl transferase family 9
CDC59_RS13390	COG0429	hydrolase of the alpha beta-hydrolase fold
CDC59_RS13400	COG4783	chaperone-mediated protein folding
CDC59_RS13405	COG0315	cyclic pyranopterin monophosphate synthase activity
CDC59_RS13415	COG4969	Belongs to the N-Me-Phe pilin family
CDC59_RS13420	COG4969	Belongs to the N-Me-Phe pilin family
CDC59_RS13425	COG0861	Integral membrane protein TerC family
CDC59_RS13430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CDC59_RS13435	COG0045	succinate-CoA ligase (ADP-forming) activity
CDC59_RS13445	COG2137	regulation of response to DNA damage stimulus
CDC59_RS13450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CDC59_RS13460	COG0642	Histidine kinase
CDC59_RS13470	COG0477	Major facilitator Superfamily
CDC59_RS13495	COG0745	RESPONSE REGULATOR receiver
CDC59_RS13515	COG0513	Belongs to the DEAD box helicase family
CDC59_RS13530	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS13535	COG2030	dehydratase
CDC59_RS13545	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS13560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC59_RS13560	COG0493	'glutamate synthase
CDC59_RS13570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CDC59_RS13575	COG1702	phosphate starvation-inducible protein PhoH
CDC59_RS13580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CDC59_RS13590	COG4535	Mg2 and Co2 transporter CorC
CDC59_RS13595	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CDC59_RS13600	COG0752	glycyl-tRNA synthetase alpha subunit
CDC59_RS13610	COG0751	glycine-tRNA ligase activity
CDC59_RS13615	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CDC59_RS13620	COG0204	Acyl-transferase
CDC59_RS13630	COG0346	lactoylglutathione lyase activity
CDC59_RS13635	COG0697	spore germination
CDC59_RS13640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CDC59_RS13645	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDC59_RS13650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC59_RS13655	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
CDC59_RS13675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CDC59_RS13685	COG0006	proline dipeptidase activity
CDC59_RS13690	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CDC59_RS13700	COG4680	protein conserved in bacteria
CDC59_RS13715	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
CDC59_RS13720	COG0138	bifunctional purine biosynthesis protein purh
CDC59_RS13725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CDC59_RS13735	COG0632	four-way junction helicase activity
CDC59_RS13740	COG2255	four-way junction helicase activity
CDC59_RS13755	COG1881	PFAM PEBP family protein
CDC59_RS13760	COG1490	D-aminoacyl-tRNA deacylase activity
CDC59_RS13765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CDC59_RS13770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
CDC59_RS13775	COG0316	Belongs to the HesB IscA family
CDC59_RS13790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CDC59_RS13795	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CDC59_RS13815	COG0418	dihydroorotase activity
CDC59_RS13825	COG0473	3-isopropylmalate dehydrogenase activity
CDC59_RS13830	COG0121	glutamine amidotransferase
CDC59_RS13835	COG1126	abc transporter atp-binding protein
CDC59_RS13840	COG0765	amino acid transport
CDC59_RS13845	COG0765	amino acid transport
CDC59_RS13855	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CDC59_RS13865	COG5265	(ABC) transporter
CDC59_RS13875	COG1024	Enoyl-CoA hydratase
CDC59_RS13880	COG0183	Belongs to the thiolase family
CDC59_RS13890	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS13905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC59_RS13910	COG3568	Endonuclease Exonuclease Phosphatase
CDC59_RS13915	COG0494	nUDIX hydrolase
CDC59_RS13925	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CDC59_RS13945	COG0500	methyltransferase
CDC59_RS13950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
CDC59_RS13965	COG2226	methyltransferase
CDC59_RS13975	COG4178	(ABC) transporter
CDC59_RS13990	COG1238	metal cluster binding
CDC59_RS13995	COG0700	Nucleoside recognition
CDC59_RS14015	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC59_RS14015	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CDC59_RS14045	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS14050	COG3265	gluconokinase activity
CDC59_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS14095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CDC59_RS14120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CDC59_RS14155	COG0629	single-stranded DNA binding
CDC59_RS14160	COG2814	Major facilitator Superfamily
CDC59_RS14180	COG1280	lysine exporter protein (LysE YggA)
CDC59_RS14185	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CDC59_RS14190	COG0693	protein deglycase activity
CDC59_RS14215	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CDC59_RS14230	COG1137	ATPase activity
CDC59_RS14235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC59_RS14240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CDC59_RS14250	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CDC59_RS14260	COG1660	Displays ATPase and GTPase activities
CDC59_RS14270	COG1194	a g-specific adenine glycosylase
CDC59_RS14280	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CDC59_RS14290	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
CDC59_RS14295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CDC59_RS14305	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CDC59_RS14310	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CDC59_RS14315	COG0193	aminoacyl-tRNA hydrolase activity
CDC59_RS14325	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CDC59_RS14330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CDC59_RS14335	COG0742	ribosomal rna small subunit methyltransferase
CDC59_RS14340	COG0612	Peptidase, M16
CDC59_RS14345	COG0612	Peptidase, M16
CDC59_RS14355	COG0625	glutathione transferase activity
CDC59_RS14365	COG3707	response regulator
CDC59_RS14375	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CDC59_RS14380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC59_RS14385	COG1116	anion transmembrane transporter activity
CDC59_RS14390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC59_RS14395	COG1741	Belongs to the pirin family
CDC59_RS14405	COG3300	MHYT domain
CDC59_RS14405	COG5001	Diguanylate cyclase
CDC59_RS14410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CDC59_RS14415	COG1999	signal sequence binding
CDC59_RS14420	COG0109	protoheme IX farnesyltransferase activity
CDC59_RS14425	COG1612	heme a metabolic process
CDC59_RS14455	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
CDC59_RS14460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC59_RS14475	COG2226	methyltransferase
CDC59_RS14480	COG1040	competence protein
CDC59_RS14490	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CDC59_RS14495	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
CDC59_RS14500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
CDC59_RS14510	COG0588	phosphoglycerate mutase activity
CDC59_RS14515	COG0793	Belongs to the peptidase S41A family
CDC59_RS14535	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CDC59_RS14540	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CDC59_RS14550	COG0189	ligase activity
CDC59_RS14560	COG0004	ammonium transporteR
CDC59_RS14605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CDC59_RS14620	COG2204	response regulator
CDC59_RS14630	COG1301	dicarboxylic acid transport
CDC59_RS14635	COG3411	Ferredoxin
CDC59_RS14645	COG1686	Belongs to the peptidase S11 family
CDC59_RS14650	COG2921	Belongs to the UPF0250 family
CDC59_RS14655	COG0583	DNA-binding transcription factor activity
CDC59_RS14665	COG0321	lipoyl(octanoyl) transferase activity
CDC59_RS14670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
CDC59_RS14690	COG0513	Belongs to the DEAD box helicase family
CDC59_RS14710	COG3511	phospholipase C
CDC59_RS14740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CDC59_RS14745	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CDC59_RS14745	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CDC59_RS14750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CDC59_RS14760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CDC59_RS14825	COG2267	carboxylic ester hydrolase activity
CDC59_RS14855	COG2197	response regulator
CDC59_RS14880	COG0018	arginyl-trna synthetase
CDC59_RS14890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CDC59_RS14895	COG4221	oxidoreductase activity
CDC59_RS14905	COG2329	Antibiotic biosynthesis monooxygenase
CDC59_RS14915	COG0789	Transcriptional regulator
CDC59_RS14920	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS14925	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
CDC59_RS14930	COG0288	reversible hydration of carbon dioxide
CDC59_RS14945	COG0183	Belongs to the thiolase family
CDC59_RS14950	COG0300	oxidoreductase activity
CDC59_RS14955	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS14970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CDC59_RS14975	COG3012	SEC-C Motif Domain Protein
CDC59_RS14980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CDC59_RS14990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CDC59_RS14995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CDC59_RS15000	COG4770	biotin carboxylase activity
CDC59_RS15020	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC59_RS15055	COG0596	Alpha beta hydrolase
CDC59_RS15120	COG1250	3-hydroxyacyl-CoA dehydrogenase
CDC59_RS15125	COG1703	isobutyryl-CoA mutase activity
CDC59_RS15125	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC59_RS15125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CDC59_RS15165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CDC59_RS15175	COG0430	RNA-3'-phosphate cyclase activity
CDC59_RS15180	COG3541	Predicted nucleotidyltransferase
CDC59_RS15185	COG1690	Belongs to the RtcB family
CDC59_RS15195	COG4650	regulator
CDC59_RS15210	COG1254	Belongs to the acylphosphatase family
CDC59_RS15255	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CDC59_RS15275	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CDC59_RS15280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CDC59_RS15290	COG0037	tRNA processing
CDC59_RS15295	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC59_RS15300	COG0546	phosphoglycolate phosphatase activity
CDC59_RS15300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CDC59_RS15320	COG0493	'glutamate synthase
CDC59_RS15335	COG0842	Transport permease protein
CDC59_RS15340	COG1131	(ABC) transporter
CDC59_RS15345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS15355	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS15360	COG0583	DNA-binding transcription factor activity
CDC59_RS15365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CDC59_RS15380	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS15390	COG2223	nitrite transmembrane transporter activity
CDC59_RS15400	COG0697	spore germination
CDC59_RS15425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CDC59_RS15445	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CDC59_RS15450	COG4682	membrane
CDC59_RS15455	COG0708	Exodeoxyribonuclease III
CDC59_RS15460	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CDC59_RS15465	COG2326	polyphosphate kinase activity
CDC59_RS15470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CDC59_RS15485	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CDC59_RS15505	COG0517	IMP dehydrogenase activity
CDC59_RS15515	COG1522	sequence-specific DNA binding
CDC59_RS15560	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS15595	COG2070	2-Nitropropane dioxygenase
CDC59_RS15600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CDC59_RS15615	COG2022	thiamine diphosphate biosynthetic process
CDC59_RS15625	COG2764	glyoxalase bleomycin resistance protein dioxygenase
CDC59_RS15635	COG0351	phosphomethylpyrimidine kinase
CDC59_RS15645	COG1785	Belongs to the alkaline phosphatase family
CDC59_RS15650	COG1785	Belongs to the alkaline phosphatase family
CDC59_RS15655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CDC59_RS15660	COG1950	PFAM Membrane protein of
CDC59_RS15665	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CDC59_RS15680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CDC59_RS15685	COG0741	lytic transglycosylase activity
CDC59_RS15695	COG0625	glutathione transferase activity
CDC59_RS15700	COG0617	tRNA 3'-terminal CCA addition
CDC59_RS15710	COG3246	L-lysine catabolic process to acetate
CDC59_RS15715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC59_RS15740	COG2204	response regulator
CDC59_RS15745	COG5000	phosphorelay sensor kinase activity
CDC59_RS15755	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CDC59_RS15760	COG0501	Belongs to the peptidase M48B family
CDC59_RS15770	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CDC59_RS15780	COG0242	peptide deformylase activity
CDC59_RS15785	COG1652	LysM domain
CDC59_RS15790	COG0758	DNA mediated transformation
CDC59_RS15805	COG0583	DNA-binding transcription factor activity
CDC59_RS15810	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS15815	COG0772	Belongs to the SEDS family
CDC59_RS15820	COG0768	penicillin binding
CDC59_RS15830	COG1792	Involved in formation and maintenance of cell shape
CDC59_RS15835	COG1077	Cell shape determining protein MreB Mrl
CDC59_RS15840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC59_RS15845	COG0154	amidase activity
CDC59_RS15860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CDC59_RS15870	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC59_RS15875	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CDC59_RS15905	COG0523	cobalamin synthesis protein
CDC59_RS15920	COG0747	negative chemotaxis
CDC59_RS15925	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CDC59_RS15930	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CDC59_RS15950	COG0592	DNA-directed DNA polymerase activity
CDC59_RS15955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CDC59_RS15965	COG1278	Cold shock
CDC59_RS15975	COG1475	DNA binding
CDC59_RS15985	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CDC59_RS15990	COG0477	Major facilitator Superfamily
CDC59_RS15995	COG4191	Histidine kinase
CDC59_RS16005	COG4377	Putative membrane peptidase family (DUF2324)
CDC59_RS16015	COG5002	protein histidine kinase activity
CDC59_RS16015	COG3447	MASE1 domain protein
CDC59_RS16015	COG5001	Diguanylate cyclase
CDC59_RS16055	COG0038	chloride channel
CDC59_RS16065	COG1881	PFAM PEBP family protein
CDC59_RS16100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS16115	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC59_RS16120	COG0745	RESPONSE REGULATOR receiver
CDC59_RS16125	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC59_RS16180	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS16190	COG1024	Enoyl-CoA hydratase
CDC59_RS16195	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS16220	COG0477	Major facilitator Superfamily
CDC59_RS16225	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CDC59_RS16230	COG3657	addiction module killer protein
CDC59_RS16235	COG2814	Major facilitator Superfamily
CDC59_RS16305	COG0725	ABC transporter, periplasmic molybdate-binding protein
CDC59_RS16320	COG0714	Associated with various cellular activities
CDC59_RS16335	COG0288	reversible hydration of carbon dioxide
CDC59_RS16340	COG0659	secondary active sulfate transmembrane transporter activity
CDC59_RS16375	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CDC59_RS16385	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
CDC59_RS16390	COG2944	sequence-specific DNA binding
CDC59_RS16455	COG3209	COG3209 Rhs family protein
CDC59_RS16475	COG4251	negative regulation of phosphorylation
CDC59_RS16475	COG5001	Diguanylate cyclase
CDC59_RS16475	COG3706	GGDEF domain
CDC59_RS16475	COG2203	Gaf domain
CDC59_RS16500	COG1902	pentaerythritol trinitrate reductase activity
CDC59_RS16545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CDC59_RS16590	COG0534	Mate efflux family protein
CDC59_RS16595	COG3251	PFAM MbtH domain protein
CDC59_RS16605	COG0529	Catalyzes the synthesis of activated sulfate
CDC59_RS16715	COG0531	amino acid
CDC59_RS16720	COG0534	Mate efflux family protein
CDC59_RS16735	COG2197	response regulator
CDC59_RS16745	COG0726	polysaccharide deacetylase
CDC59_RS16745	COG1649	PFAM Uncharacterised BCR, COG1649
CDC59_RS16750	COG1215	transferase activity, transferring glycosyl groups
CDC59_RS16765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS16770	COG2274	protein secretion by the type I secretion system
CDC59_RS16805	COG0840	transmembrane signaling receptor activity
CDC59_RS16830	COG0583	DNA-binding transcription factor activity
CDC59_RS16835	COG1695	Transcriptional regulator
CDC59_RS16850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC59_RS16860	COG0745	RESPONSE REGULATOR receiver
CDC59_RS16865	COG2205	protein histidine kinase activity
CDC59_RS16880	COG0589	response to stress
CDC59_RS16900	COG0789	Transcriptional regulator
CDC59_RS16910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CDC59_RS16935	COG1764	response to oxidative stress
CDC59_RS16945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CDC59_RS16970	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC59_RS16975	COG2188	Transcriptional regulator
CDC59_RS16985	COG2197	response regulator
CDC59_RS17005	COG1815	bacterial-type flagellum-dependent cell motility
CDC59_RS17015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CDC59_RS17020	COG1749	Flagellar hook protein flgE
CDC59_RS17025	COG4787	bacterial-type flagellum-dependent cell motility
CDC59_RS17035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CDC59_RS17040	COG1706	bacterial-type flagellum-dependent cell motility
CDC59_RS17050	COG1256	bacterial-type flagellum assembly
CDC59_RS17090	COG1987	bacterial-type flagellum assembly
CDC59_RS17095	COG1338	Plays a role in the flagellum-specific transport system
CDC59_RS17125	COG2197	response regulator
CDC59_RS17155	COG1846	Transcriptional regulator
CDC59_RS17170	COG1677	Flagellar hook-basal body complex protein FliE
CDC59_RS17180	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CDC59_RS17190	COG1157	protein secretion by the type III secretion system
CDC59_RS17210	COG5001	Diguanylate cyclase
CDC59_RS17210	COG2203	Gaf domain
CDC59_RS17210	COG4251	negative regulation of phosphorylation
CDC59_RS17210	COG3706	GGDEF domain
CDC59_RS17225	COG5001	Diguanylate cyclase
CDC59_RS17225	COG2203	Gaf domain
CDC59_RS17225	COG3706	GGDEF domain
CDC59_RS17225	COG4251	negative regulation of phosphorylation
CDC59_RS17245	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS17300	COG2223	nitrite transmembrane transporter activity
CDC59_RS17310	COG4774	siderophore transport
CDC59_RS17330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CDC59_RS17335	COG2423	ornithine cyclodeaminase activity
CDC59_RS17340	COG4264	IucA IucC family
CDC59_RS17345	COG2814	Major facilitator Superfamily
CDC59_RS17350	COG4264	IucA IucC family
CDC59_RS17355	COG4264	IucA IucC family
CDC59_RS17365	COG0019	diaminopimelate decarboxylase activity
CDC59_RS17425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CDC59_RS17455	COG1214	PFAM Peptidase M22, glycoprotease
CDC59_RS17455	COG0456	acetyltransferase
CDC59_RS17460	COG0583	DNA-binding transcription factor activity
CDC59_RS17485	COG1942	4-Oxalocrotonate Tautomerase
CDC59_RS17525	COG1181	Belongs to the D-alanine--D-alanine ligase family
CDC59_RS17530	COG2814	Major facilitator Superfamily
CDC59_RS17535	COG0667	Aldo Keto reductase
CDC59_RS17550	COG0730	response to heat
CDC59_RS17575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CDC59_RS17590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC59_RS17615	COG1607	acyl-coa hydrolase
CDC59_RS17635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CDC59_RS17645	COG0765	amino acid transport
CDC59_RS17650	COG0765	amino acid transport
CDC59_RS17655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS17700	COG1846	Transcriptional regulator
CDC59_RS17705	COG1024	Enoyl-CoA hydratase
CDC59_RS17710	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS17715	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS17745	COG0657	acetylesterase activity
CDC59_RS17750	COG2226	methyltransferase
CDC59_RS17760	COG2814	Major facilitator Superfamily
CDC59_RS17770	COG1640	4-alpha-glucanotransferase
CDC59_RS17775	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CDC59_RS17785	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CDC59_RS17795	COG0366	Alpha amylase catalytic
CDC59_RS17800	COG0297	glycogen (starch) synthase activity
CDC59_RS17810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CDC59_RS17815	COG4558	Periplasmic binding protein
CDC59_RS17820	COG3720	iron ion transport
CDC59_RS17825	COG4771	TonB-dependent receptor
CDC59_RS17835	COG3634	alkyl hydroperoxide reductase activity
CDC59_RS17840	COG0735	belongs to the Fur family
CDC59_RS17860	COG1918	ferrous iron import across plasma membrane
CDC59_RS17860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CDC59_RS17870	COG5002	protein histidine kinase activity
CDC59_RS17870	COG3447	MASE1 domain protein
CDC59_RS17870	COG5001	Diguanylate cyclase
CDC59_RS17880	COG0840	transmembrane signaling receptor activity
CDC59_RS17900	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CDC59_RS17915	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
CDC59_RS17925	COG0456	acetyltransferase
CDC59_RS17925	COG0454	-acetyltransferase
CDC59_RS17935	COG0688	phosphatidylethanolamine metabolic process
CDC59_RS17940	COG2814	Major facilitator Superfamily
CDC59_RS17960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CDC59_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS18035	COG2824	Alkylphosphonate utilization operon protein PhnA
CDC59_RS18075	COG3210	domain, Protein
CDC59_RS18085	COG2831	hemolysin activation secretion protein
CDC59_RS18090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC59_RS18110	COG1113	amino acid transport
CDC59_RS18120	COG0753	catalase activity
CDC59_RS18125	COG0644	oxidoreductase
CDC59_RS18155	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
CDC59_RS18175	COG0705	Rhomboid family
CDC59_RS18180	COG3300	MHYT domain
CDC59_RS18180	COG5001	Diguanylate cyclase
CDC59_RS18230	COG0583	DNA-binding transcription factor activity
CDC59_RS18270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CDC59_RS18280	COG2188	Transcriptional regulator
CDC59_RS18285	COG0826	peptidase U32
CDC59_RS18290	COG0826	peptidase U32
CDC59_RS18295	COG3154	lipid carrier protein
CDC59_RS18305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CDC59_RS18325	COG2223	nitrite transmembrane transporter activity
CDC59_RS18335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
CDC59_RS18340	COG1140	nitrate reductase beta subunit
CDC59_RS18345	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
CDC59_RS18350	COG2181	nitrate reductase activity
CDC59_RS18355	COG1763	Mo-molybdopterin cofactor biosynthetic process
CDC59_RS18360	COG3850	Histidine kinase
CDC59_RS18365	COG2197	response regulator
CDC59_RS18370	COG0204	Acyl-transferase
CDC59_RS18400	COG4651	solute:proton antiporter activity
CDC59_RS18400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CDC59_RS18415	COG2192	nodulation
CDC59_RS18435	COG0151	Belongs to the GarS family
CDC59_RS18445	COG2267	carboxylic ester hydrolase activity
CDC59_RS18455	COG2885	chlorophyll binding
CDC59_RS18470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CDC59_RS18495	COG0583	DNA-binding transcription factor activity
CDC59_RS18505	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CDC59_RS18560	COG3209	COG3209 Rhs family protein
CDC59_RS18590	COG1126	abc transporter atp-binding protein
CDC59_RS18595	COG0765	amino acid transport
CDC59_RS18600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS18605	COG1522	sequence-specific DNA binding
CDC59_RS18610	COG2423	ornithine cyclodeaminase activity
CDC59_RS18635	COG0402	S-adenosylhomocysteine deaminase activity
CDC59_RS18640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CDC59_RS18695	COG0537	adenosine 5'-monophosphoramidase activity
CDC59_RS18705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC59_RS18715	COG0840	transmembrane signaling receptor activity
CDC59_RS18730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CDC59_RS18750	COG0668	transmembrane transport
CDC59_RS18785	COG3706	GGDEF domain
CDC59_RS18790	COG1914	H( )-stimulated, divalent metal cation uptake system
CDC59_RS18795	COG0443	Heat shock 70 kDa protein
CDC59_RS18815	COG2910	NAD(P)H-binding
CDC59_RS18835	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS18850	COG0308	aminopeptidase N
CDC59_RS18885	COG1459	type II secretion system
CDC59_RS18905	COG2165	general secretion pathway protein
CDC59_RS18955	COG3396	Phenylacetate-CoA oxygenase
CDC59_RS18960	COG3460	Phenylacetate-CoA oxygenase
CDC59_RS18965	COG3396	Phenylacetate-CoA oxygenase
CDC59_RS18970	COG2151	metal-sulfur cluster biosynthetic enzyme
CDC59_RS18975	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CDC59_RS19030	COG1733	regulation of RNA biosynthetic process
CDC59_RS19060	COG0778	Nitroreductase
CDC59_RS19065	COG1797	cobyrinic acid a,c-diamide synthase activity
CDC59_RS19100	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CDC59_RS19105	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
CDC59_RS19110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CDC59_RS19110	COG1648	precorrin-2 dehydrogenase activity
CDC59_RS19125	COG3411	Ferredoxin
CDC59_RS19130	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
CDC59_RS19135	COG1126	abc transporter atp-binding protein
CDC59_RS19140	COG0765	amino acid transport
CDC59_RS19145	COG4597	amino acid ABC transporter
CDC59_RS19160	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CDC59_RS19175	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CDC59_RS19180	COG3251	PFAM MbtH domain protein
CDC59_RS19210	COG1522	sequence-specific DNA binding
CDC59_RS19215	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CDC59_RS19220	COG1024	Enoyl-CoA hydratase
CDC59_RS19225	COG1024	Enoyl-CoA hydratase
CDC59_RS19245	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS19270	COG2814	Major facilitator Superfamily
CDC59_RS19285	COG0519	Catalyzes the synthesis of GMP from XMP
CDC59_RS19290	COG2807	transmembrane transport
CDC59_RS19310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS19320	COG1024	Enoyl-CoA hydratase
CDC59_RS19345	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CDC59_RS19350	COG0583	DNA-binding transcription factor activity
CDC59_RS19355	COG0259	pyridoxamine-phosphate oxidase activity
CDC59_RS19365	COG0134	indole-3-glycerol-phosphate synthase activity
CDC59_RS19370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CDC59_RS19400	COG1960	acyl-CoA dehydrogenase activity
CDC59_RS19420	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
CDC59_RS19430	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CDC59_RS19435	COG1690	Belongs to the RtcB family
CDC59_RS19525	COG1858	cytochrome C peroxidase
CDC59_RS19530	COG1730	sister chromatid segregation
CDC59_RS19550	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CDC59_RS19580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
CDC59_RS19720	COG1649	PFAM Uncharacterised BCR, COG1649
CDC59_RS19730	COG2885	chlorophyll binding
CDC59_RS19810	COG0436	Aminotransferase
CDC59_RS19835	COG0587	DNA-directed DNA polymerase activity
CDC59_RS19840	COG3620	sequence-specific DNA binding
CDC59_RS19845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CDC59_RS19860	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CDC59_RS19875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CDC59_RS19890	COG3842	ATPase activity
CDC59_RS19905	COG1840	ABC-type Fe3 transport system, periplasmic component
CDC59_RS19915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CDC59_RS19920	COG4206	TonB-dependent receptor
CDC59_RS19940	COG0579	oxidoreductase
CDC59_RS19960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC59_RS19970	COG0697	spore germination
CDC59_RS19985	COG0583	DNA-binding transcription factor activity
CDC59_RS19990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CDC59_RS20000	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC59_RS20005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS20015	COG2271	Major facilitator Superfamily
CDC59_RS20025	COG2721	sulfolactate sulfo-lyase activity
CDC59_RS20030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC59_RS20050	COG1051	belongs to the nudix hydrolase family
CDC59_RS20050	COG1056	cytidyltransferase-related domain
CDC59_RS20075	COG0840	transmembrane signaling receptor activity
CDC59_RS20080	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
CDC59_RS20125	COG1595	DNA-templated transcription, initiation
CDC59_RS20135	COG2197	response regulator
CDC59_RS20140	COG0745	RESPONSE REGULATOR receiver
CDC59_RS20180	COG4790	Type iii secretion
CDC59_RS20195	COG4789	Type iii secretion
CDC59_RS20200	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CDC59_RS20245	COG2207	Transcriptional regulator
CDC59_RS20250	COG1450	Type ii and iii secretion system protein
CDC59_RS20255	COG4886	Leucine-rich repeat (LRR) protein
CDC59_RS20340	COG1674	ftsk spoiiie
CDC59_RS20355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CDC59_RS20365	COG1396	sequence-specific DNA binding
CDC59_RS20385	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS20405	COG1063	alcohol dehydrogenase
CDC59_RS20410	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS20415	COG3265	gluconokinase activity
CDC59_RS20425	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC59_RS20430	COG0436	Aminotransferase
CDC59_RS20440	COG0511	ligase activity, forming carbon-carbon bonds
CDC59_RS20450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CDC59_RS20455	COG1984	allophanate hydrolase subunit 2
CDC59_RS20465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CDC59_RS20470	COG4221	oxidoreductase activity
CDC59_RS20475	COG0765	amino acid transport
CDC59_RS20480	COG0765	amino acid transport
CDC59_RS20485	COG1126	abc transporter atp-binding protein
CDC59_RS20490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS20500	COG1882	Formate acetyltransferase
CDC59_RS20520	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC59_RS20535	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CDC59_RS20655	COG0038	chloride channel
CDC59_RS20660	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CDC59_RS20700	COG0318	PFAM AMP-dependent synthetase and ligase
CDC59_RS20735	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CDC59_RS20735	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
CDC59_RS20740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CDC59_RS20785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CDC59_RS20795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CDC59_RS20815	COG0110	maltose O-acetyltransferase activity
CDC59_RS20905	COG1132	(ABC) transporter
CDC59_RS20910	COG4771	TonB-dependent receptor
CDC59_RS20925	COG2226	methyltransferase
CDC59_RS20925	COG3433	isochorismatase activity
CDC59_RS20925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CDC59_RS20950	COG1021	2,3-dihydroxybenzoate-AMP ligase
CDC59_RS20960	COG0840	transmembrane signaling receptor activity
CDC59_RS20990	COG0473	3-isopropylmalate dehydrogenase activity
CDC59_RS20995	COG4172	Belongs to the ABC transporter superfamily
CDC59_RS21000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CDC59_RS21005	COG0601	transmembrane transport
CDC59_RS21010	COG0747	negative chemotaxis
CDC59_RS21015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS21035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CDC59_RS21045	COG1522	sequence-specific DNA binding
CDC59_RS21060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CDC59_RS21060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS21080	COG1473	amidohydrolase
CDC59_RS21110	COG0583	DNA-binding transcription factor activity
CDC59_RS21130	COG3220	belongs to the UPF0276 family
CDC59_RS21140	COG2259	Doxx family
CDC59_RS21175	COG2223	nitrite transmembrane transporter activity
CDC59_RS21180	COG0243	molybdopterin cofactor binding
CDC59_RS21190	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CDC59_RS21195	COG3300	MHYT domain
CDC59_RS21195	COG5001	Diguanylate cyclase
CDC59_RS21200	COG3158	transport of potassium into the cell
CDC59_RS21205	COG1278	Cold shock
CDC59_RS21220	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CDC59_RS21235	COG4689	acetoacetate decarboxylase
CDC59_RS21240	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS21270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CDC59_RS21290	COG1621	beta-fructofuranosidase activity
CDC59_RS21300	COG1609	Transcriptional regulator
CDC59_RS21390	COG3210	domain, Protein
CDC59_RS21400	COG2831	hemolysin activation secretion protein
CDC59_RS21410	COG2124	cytochrome p450
CDC59_RS21420	COG0673	inositol 2-dehydrogenase activity
CDC59_RS21475	COG4964	Belongs to the GSP D family
CDC59_RS21515	COG2197	response regulator
CDC59_RS21550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CDC59_RS21555	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
CDC59_RS21565	COG1877	trehalose-phosphatase activity
CDC59_RS21575	COG1846	Transcriptional regulator
CDC59_RS21580	COG1764	response to oxidative stress
CDC59_RS21595	COG2951	lytic endotransglycosylase activity
CDC59_RS21600	COG0583	DNA-binding transcription factor activity
CDC59_RS21605	COG0657	acetylesterase activity
CDC59_RS21610	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS21625	COG1279	arginine transmembrane transporter activity
CDC59_RS21630	COG0583	DNA-binding transcription factor activity
CDC59_RS21645	COG2197	response regulator
CDC59_RS21655	COG2066	Belongs to the glutaminase family
CDC59_RS21660	COG4149	molybdate abc transporter
CDC59_RS21665	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CDC59_RS21680	COG5001	Diguanylate cyclase
CDC59_RS21680	COG3300	MHYT domain
CDC59_RS21700	COG3813	Protein conserved in bacteria
CDC59_RS21720	COG0745	RESPONSE REGULATOR receiver
CDC59_RS21725	COG2205	protein histidine kinase activity
CDC59_RS21750	COG1253	flavin adenine dinucleotide binding
CDC59_RS21755	COG1858	cytochrome C peroxidase
CDC59_RS21795	COG2205	protein histidine kinase activity
CDC59_RS21795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS21810	COG2274	protein secretion by the type I secretion system
CDC59_RS21835	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
CDC59_RS21850	COG0800	Aldolase
CDC59_RS21855	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC59_RS21860	COG2197	response regulator
CDC59_RS21865	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CDC59_RS21890	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC59_RS21930	COG1294	oxidase, subunit
CDC59_RS21935	COG1271	oxidase subunit
CDC59_RS21940	COG3300	MHYT domain
CDC59_RS21940	COG5001	Diguanylate cyclase
CDC59_RS21945	COG0840	transmembrane signaling receptor activity
CDC59_RS21960	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CDC59_RS21970	COG0438	transferase activity, transferring glycosyl groups
CDC59_RS21975	COG0534	Mate efflux family protein
CDC59_RS22030	COG0243	molybdopterin cofactor binding
CDC59_RS22035	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC59_RS22045	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CDC59_RS22050	COG2223	nitrite transmembrane transporter activity
CDC59_RS22055	COG0840	transmembrane signaling receptor activity
CDC59_RS22070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CDC59_RS22085	COG0508	dehydrogenase complex catalyzes the overall conversion of
CDC59_RS22085	COG0596	Alpha beta hydrolase
CDC59_RS22105	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC59_RS22110	COG0436	Aminotransferase
CDC59_RS22115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
CDC59_RS22115	COG0473	3-isopropylmalate dehydrogenase activity
CDC59_RS22145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CDC59_RS22150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CDC59_RS22165	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CDC59_RS22170	COG1454	alcohol dehydrogenase
CDC59_RS22175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CDC59_RS22195	COG1028	Short-chain dehydrogenase reductase Sdr
CDC59_RS22220	COG0477	Major facilitator Superfamily
CDC59_RS22225	COG0114	fumarate hydratase activity
CDC59_RS22260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CDC59_RS22280	COG3766	membrane
CDC59_RS22285	COG0683	leucine binding
CDC59_RS22310	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CDC59_RS22385	COG1522	sequence-specific DNA binding
CDC59_RS22420	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CDC59_RS22455	COG3278	Belongs to the heme-copper respiratory oxidase family
CDC59_RS22465	COG0596	Alpha beta hydrolase
CDC59_RS22500	COG1271	oxidase subunit
CDC59_RS22505	COG1294	oxidase, subunit
CDC59_RS22510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CDC59_RS22520	COG0251	oxidation-reduction process
CDC59_RS22555	COG3550	peptidyl-serine autophosphorylation
CDC59_RS22575	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CDC59_RS22595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CDC59_RS22600	COG0730	response to heat
CDC59_RS22605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CDC59_RS22615	COG0583	DNA-binding transcription factor activity
CDC59_RS22620	COG0730	response to heat
CDC59_RS22645	COG0668	transmembrane transport
CDC59_RS22650	COG1742	UPF0060 membrane protein
CDC59_RS22720	COG0352	thiamine-phosphate diphosphorylase activity
CDC59_RS22725	COG0477	Major facilitator Superfamily
CDC59_RS22730	COG1454	alcohol dehydrogenase
CDC59_RS22735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CDC59_RS22740	COG0642	Histidine kinase
CDC59_RS22760	COG0837	glucose binding
CDC59_RS22770	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CDC59_RS22795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
CDC59_RS22800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
CDC59_RS22810	COG1845	cytochrome c oxidase, subunit III
CDC59_RS22845	COG2271	Major facilitator Superfamily
CDC59_RS22855	COG0583	DNA-binding transcription factor activity
CDC59_RS22860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CDC59_RS22870	COG0765	amino acid transport
CDC59_RS22875	COG0010	Belongs to the arginase family
CDC59_RS22880	COG2197	response regulator
CDC59_RS22910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CDC59_RS22910	COG2022	thiamine diphosphate biosynthetic process
CDC59_RS22915	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS22925	COG0583	DNA-binding transcription factor activity
CDC59_RS22930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS22935	COG2814	Major facilitator Superfamily
CDC59_RS22945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS23010	COG1012	belongs to the aldehyde dehydrogenase family
CDC59_RS23015	COG0473	3-isopropylmalate dehydrogenase activity
CDC59_RS23025	COG2271	Major facilitator Superfamily
CDC59_RS23030	COG2721	sulfolactate sulfo-lyase activity
CDC59_RS23040	COG1475	DNA binding
CDC59_RS23050	COG3969	phosphoadenosine phosphosulfate
CDC59_RS23055	COG5295	Hep Hag repeat protein
CDC59_RS23070	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
CDC59_RS23075	COG0745	RESPONSE REGULATOR receiver
CDC59_RS23080	COG2201	protein-glutamate methylesterase activity
CDC59_RS23085	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CDC59_RS23095	COG0840	transmembrane signaling receptor activity
CDC59_RS23100	COG0835	chemotaxis
CDC59_RS23110	COG0745	RESPONSE REGULATOR receiver
CDC59_RS23150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
CDC59_RS23155	COG3384	dioxygenase
CDC59_RS23165	COG0583	DNA-binding transcription factor activity
CDC59_RS23175	COG2159	amidohydrolase
CDC59_RS23185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
CDC59_RS23195	COG2205	protein histidine kinase activity
CDC59_RS23215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CDC59_RS23235	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CDC59_RS23240	COG2831	hemolysin activation secretion protein
CDC59_RS23245	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CDC59_RS23245	COG3210	domain, Protein
CDC59_RS23245	COG3064	Membrane
CDC59_RS23330	COG2916	Histone family protein nucleoid-structuring protein H-NS
CDC59_RS23570	COG0697	spore germination
CDC59_RS23575	COG0583	DNA-binding transcription factor activity
CDC59_RS23600	COG5297	Belongs to the glycosyl hydrolase family 6
CDC59_RS23655	COG1104	cysteine desulfurase activity
CDC59_RS23685	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
CDC59_RS23695	COG4213	ABC transporter substrate-binding protein
CDC59_RS23700	COG1129	ABC transporter
CDC59_RS23705	COG4214	carbohydrate transport
CDC59_RS23715	COG1609	Transcriptional regulator
CDC59_RS23735	COG0300	oxidoreductase activity
CDC59_RS23745	COG0583	DNA-binding transcription factor activity
CDC59_RS23775	COG1968	undecaprenyl-diphosphatase activity
CDC59_RS23790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CDC59_RS23795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CDC59_RS23840	COG4977	sequence-specific DNA binding
CDC59_RS23865	COG1595	DNA-templated transcription, initiation
CDC59_RS23895	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CDC59_RS23925	COG2204	response regulator
CDC59_RS23940	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CDC59_RS23960	COG2205	protein histidine kinase activity
CDC59_RS23970	COG2252	PERMEase