locus-tag	class	description
HY59_RS00020	COG3085	chromosome segregation
HY59_RS00040	COG3978	acetolactate synthase activity
HY59_RS00045	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HY59_RS00060	COG0583	DNA-binding transcription factor activity
HY59_RS00075	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HY59_RS00095	COG3118	belongs to the thioredoxin family
HY59_RS00100	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HY59_RS00105	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HY59_RS00115	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HY59_RS00120	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HY59_RS00125	COG1088	dTDP-glucose 4,6-dehydratase activity
HY59_RS00130	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HY59_RS00135	COG0456	acetyltransferase
HY59_RS00140	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HY59_RS00145	COG2244	polysaccharide biosynthetic process
HY59_RS00190	COG3071	HemY protein
HY59_RS00195	COG2959	enzyme of heme biosynthesis
HY59_RS00210	COG3072	Adenylate cyclase
HY59_RS00240	COG1011	Hydrolase
HY59_RS00245	COG0210	DNA helicase
HY59_RS00265	COG2050	protein possibly involved in aromatic compounds catabolism
HY59_RS00280	COG1280	lysine exporter protein (LysE YggA)
HY59_RS00285	COG1280	lysine exporter protein (LysE YggA)
HY59_RS00290	COG2267	carboxylic ester hydrolase activity
HY59_RS00295	COG0561	phosphatase activity
HY59_RS00300	COG0697	spore germination
HY59_RS00305	COG0583	DNA-binding transcription factor activity
HY59_RS00320	COG0412	Dienelactone hydrolase
HY59_RS00340	COG3165	ubiquinone biosynthetic process from chorismate
HY59_RS00360	COG0805	protein transport
HY59_RS00400	COG1739	Uncharacterized protein family UPF0029
HY59_RS00410	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HY59_RS00475	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HY59_RS00480	COG0250	Participates in transcription elongation, termination and antitermination
HY59_RS00515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HY59_RS00520	COG1447	Phosphotransferase system cellobiose-specific component IIA
HY59_RS00530	COG3706	GGDEF domain
HY59_RS00535	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HY59_RS00545	COG2104	thiamine diphosphate biosynthetic process
HY59_RS00550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HY59_RS00565	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HY59_RS00650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HY59_RS00675	COG1410	methionine synthase
HY59_RS00675	COG0646	methionine synthase
HY59_RS00690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HY59_RS00730	COG1187	pseudouridine synthase activity
HY59_RS00745	COG0527	aspartate kinase activity
HY59_RS00755	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HY59_RS00790	COG4580	involved in the transport of maltose and maltodextrins
HY59_RS00815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HY59_RS00825	COG0534	Mate efflux family protein
HY59_RS00830	COG3237	CsbD-like
HY59_RS00835	COG0735	belongs to the Fur family
HY59_RS00845	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HY59_RS00860	COG0305	Participates in initiation and elongation during chromosome replication
HY59_RS00865	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HY59_RS00870	COG1448	Aminotransferase
HY59_RS00875	COG3700	Belongs to the class B bacterial acid phosphatase family
HY59_RS00880	COG0432	Pfam Uncharacterised protein family UPF0047
HY59_RS00885	COG2315	Protein conserved in bacteria
HY59_RS00895	COG0629	single-stranded DNA binding
HY59_RS00905	COG4771	TonB-dependent receptor
HY59_RS00915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HY59_RS00925	COG3710	Transcriptional regulator
HY59_RS00930	COG2197	response regulator
HY59_RS00945	COG3188	usher protein
HY59_RS00965	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HY59_RS00985	COG2252	PERMEase
HY59_RS00990	COG0025	NhaP-type Na H and K H
HY59_RS00995	COG0583	DNA-binding transcription factor activity
HY59_RS01000	COG1380	Effector of murein hydrolase LrgA
HY59_RS01005	COG1346	cytolysis
HY59_RS01015	COG3162	membrane
HY59_RS01020	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HY59_RS01025	COG1301	dicarboxylic acid transport
HY59_RS01030	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HY59_RS01035	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS01040	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS01055	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS01060	COG1129	ABC transporter
HY59_RS01065	COG0784	Response regulator, receiver
HY59_RS01065	COG4191	Histidine kinase
HY59_RS01070	COG1940	carbohydrate kinase activity
HY59_RS01075	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HY59_RS01080	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS01085	COG1129	ABC transporter
HY59_RS01090	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS01095	COG1737	Transcriptional regulator
HY59_RS01100	COG0698	ribose 5-phosphate isomerase
HY59_RS01110	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HY59_RS01115	COG0456	acetyltransferase
HY59_RS01125	COG3454	Phosphonate metabolism
HY59_RS01130	COG4778	phosphonate C-P lyase system protein PhnL
HY59_RS01135	COG4107	phosphonate C-P lyase system protein PhnK
HY59_RS01140	COG3627	carbon phosphorus lyase activity
HY59_RS01145	COG3626	phosphonate metabolism
HY59_RS01150	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HY59_RS01155	COG3624	Phosphonate C-P lyase system protein PhnG
HY59_RS01160	COG2188	Transcriptional regulator
HY59_RS01165	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HY59_RS01170	COG2824	Alkylphosphonate utilization operon protein PhnA
HY59_RS01180	COG2169	Transcriptional regulator
HY59_RS01185	COG1486	melibiose metabolic process
HY59_RS01200	COG0861	Integral membrane protein TerC family
HY59_RS01215	COG0626	cystathionine gamma-synthase activity
HY59_RS01220	COG1757	Na H antiporter
HY59_RS01225	COG0251	oxidation-reduction process
HY59_RS01230	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HY59_RS01250	COG1309	transcriptional regulator
HY59_RS01265	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HY59_RS01270	COG1027	Aspartate ammonia-lyase
HY59_RS01275	COG3030	protein affecting phage T7 exclusion by the F plasmid
HY59_RS01280	COG0531	amino acid
HY59_RS01290	COG0459	protein refolding
HY59_RS01300	COG1509	lysine 2,3-aminomutase activity
HY59_RS01310	COG5510	response to toxic substance
HY59_RS01315	COG2076	Multidrug Resistance protein
HY59_RS01320	COG3040	lipid binding
HY59_RS01335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HY59_RS01340	COG1053	succinate dehydrogenase
HY59_RS01345	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
HY59_RS01350	COG1511	domain protein
HY59_RS01350	COG3264	Mechanosensitive ion channel
HY59_RS01365	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HY59_RS01370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS01390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HY59_RS01395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HY59_RS01395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HY59_RS01400	COG0802	atpase or kinase
HY59_RS01405	COG0860	N-Acetylmuramoyl-L-alanine amidase
HY59_RS01425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HY59_RS01430	COG0330	HflC and HflK could
HY59_RS01435	COG0330	HflC and HflK could
HY59_RS01440	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HY59_RS01455	COG0557	exoribonuclease II activity
HY59_RS01460	COG2515	1-aminocyclopropane-1-carboxylate deaminase
HY59_RS01465	COG1794	racemase activity, acting on amino acids and derivatives
HY59_RS01475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS01480	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HY59_RS01485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HY59_RS01490	COG0477	Major facilitator Superfamily
HY59_RS01495	COG1960	acyl-CoA dehydrogenase activity
HY59_RS01505	COG3650	response to hydrogen peroxide
HY59_RS01510	COG1073	alpha beta
HY59_RS01530	COG3414	Phosphotransferase system galactitol-specific IIB component
HY59_RS01565	COG2965	DNA replication, synthesis of RNA primer
HY59_RS01570	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HY59_RS01575	COG0359	binds to the 23S rRNA
HY59_RS01580	COG3061	Opacity-associated protein A
HY59_RS01585	COG0545	Peptidyl-prolyl cis-trans isomerase
HY59_RS01590	COG1113	amino acid transport
HY59_RS01600	COG0697	spore germination
HY59_RS01610	COG0702	epimerase
HY59_RS01615	COG1733	regulation of RNA biosynthetic process
HY59_RS01630	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HY59_RS01655	COG1253	flavin adenine dinucleotide binding
HY59_RS01665	COG0729	surface antigen
HY59_RS01670	COG2911	Protein conserved in bacteria
HY59_RS01675	COG2105	PFAM AIG2 family protein
HY59_RS01685	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS01690	COG1129	ABC transporter
HY59_RS01695	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS01700	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS01710	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HY59_RS01730	COG0312	modulator of DNA gyrase
HY59_RS01765	COG3964	amidohydrolase
HY59_RS01780	COG2706	6-phosphogluconolactonase activity
HY59_RS01785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS01785	COG3711	transcriptional antiterminator
HY59_RS01810	COG1486	melibiose metabolic process
HY59_RS01815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS01820	COG0366	Alpha amylase catalytic
HY59_RS01825	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS01825	COG1263	PTS System
HY59_RS01830	COG1609	Transcriptional regulator
HY59_RS01840	COG3525	Glycosyl hydrolase, family 20, catalytic domain
HY59_RS01845	COG0251	oxidation-reduction process
HY59_RS01850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
HY59_RS01860	COG2731	YhcH YjgK YiaL family protein
HY59_RS01890	COG2927	DNA polymerase III (CHI subunit)
HY59_RS01900	COG0795	lipopolysaccharide-transporting ATPase activity
HY59_RS01905	COG0795	lipopolysaccharide-transporting ATPase activity
HY59_RS01910	COG0583	DNA-binding transcription factor activity
HY59_RS01920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HY59_RS01925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HY59_RS01930	COG2271	Major facilitator Superfamily
HY59_RS01935	COG0549	Belongs to the carbamate kinase family
HY59_RS01940	COG0433	COG0433 Predicted ATPase
HY59_RS01955	COG3718	enzyme involved in inositol metabolism
HY59_RS01960	COG1737	Transcriptional regulator
HY59_RS01960	COG0837	glucose binding
HY59_RS01965	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS01970	COG3962	Belongs to the TPP enzyme family
HY59_RS01980	COG1082	Xylose isomerase domain protein TIM barrel
HY59_RS01990	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HY59_RS01995	COG0129	dihydroxy-acid dehydratase activity
HY59_RS02000	COG2211	Major facilitator Superfamily
HY59_RS02005	COG3507	Belongs to the glycosyl hydrolase 43 family
HY59_RS02010	COG1414	Transcriptional regulator
HY59_RS02020	COG3842	ATPase activity
HY59_RS02025	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HY59_RS02030	COG0395	ABC-type sugar transport system, permease component
HY59_RS02035	COG1175	transmembrane transport
HY59_RS02040	COG1064	alcohol dehydrogenase
HY59_RS02050	COG0582	viral genome integration into host DNA
HY59_RS02105	COG2801	Transposase and inactivated derivatives
HY59_RS02110	COG3507	Belongs to the glycosyl hydrolase 43 family
HY59_RS02115	COG2211	Major facilitator Superfamily
HY59_RS02125	COG4580	involved in the transport of maltose and maltodextrins
HY59_RS02130	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HY59_RS02145	COG3423	Transcriptional regulator
HY59_RS02150	COG1278	Cold shock
HY59_RS02155	COG0401	homolog of Blt101
HY59_RS02160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HY59_RS02170	COG1904	glucuronate isomerase
HY59_RS02175	COG1312	Catalyzes the dehydration of D-mannonate
HY59_RS02180	COG0583	DNA-binding transcription factor activity
HY59_RS02185	COG1942	4-Oxalocrotonate Tautomerase
HY59_RS02210	COG3710	Transcriptional regulator
HY59_RS02270	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HY59_RS02275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS02280	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS02285	COG1538	Outer membrane efflux protein
HY59_RS02290	COG0745	RESPONSE REGULATOR receiver
HY59_RS02295	COG5002	protein histidine kinase activity
HY59_RS02300	COG2850	peptidyl-arginine hydroxylation
HY59_RS02315	COG0842	Transport permease protein
HY59_RS02320	COG0842	Transport permease protein
HY59_RS02320	COG1129	ABC transporter
HY59_RS02325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS02330	COG3706	GGDEF domain
HY59_RS02335	COG0180	Tryptophanyl-tRNA synthetase
HY59_RS02340	COG0814	amino acid
HY59_RS02370	COG4869	propanediol catabolic process
HY59_RS02375	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HY59_RS02380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HY59_RS02385	COG1882	Formate acetyltransferase
HY59_RS02400	COG1454	alcohol dehydrogenase
HY59_RS02400	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS02435	COG2249	NAD(P)H dehydrogenase (quinone) activity
HY59_RS02440	COG0583	DNA-binding transcription factor activity
HY59_RS02460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HY59_RS02465	COG5457	Domain of unknown function (DUF1127)
HY59_RS02475	COG1566	PFAM secretion protein HlyD family protein
HY59_RS02490	COG1924	4 iron, 4 sulfur cluster binding
HY59_RS02495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HY59_RS02505	COG0583	DNA-binding transcription factor activity
HY59_RS02510	COG1301	dicarboxylic acid transport
HY59_RS02515	COG0626	cystathionine gamma-synthase activity
HY59_RS02520	COG2733	membrane
HY59_RS02540	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS02550	COG0523	cobalamin synthesis protein
HY59_RS02555	COG2879	small protein
HY59_RS02560	COG1966	Carbon starvation protein
HY59_RS02565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HY59_RS02570	COG2368	4-hydroxyphenylacetate
HY59_RS02590	COG3971	2-oxopent-4-enoate hydratase activity
HY59_RS02600	COG3384	dioxygenase
HY59_RS02605	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS02615	COG0179	Fumarylacetoacetate (FAA) hydrolase
HY59_RS02620	COG1846	Transcriptional regulator
HY59_RS02650	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HY59_RS02655	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS02660	COG0531	amino acid
HY59_RS02675	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HY59_RS02690	COG3734	2-keto-3-deoxy-galactonokinase
HY59_RS02695	COG0800	Aldolase
HY59_RS02700	COG1737	Transcriptional regulator
HY59_RS02710	COG0456	acetyltransferase
HY59_RS02725	COG1484	DNA-dependent DNA replication
HY59_RS02740	COG2966	Psort location CytoplasmicMembrane, score
HY59_RS02755	COG2197	response regulator
HY59_RS02760	COG2197	response regulator
HY59_RS02765	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HY59_RS02770	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS02775	COG4114	ferric iron reductase
HY59_RS02780	COG3706	GGDEF domain
HY59_RS02810	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HY59_RS02815	COG0456	acetyltransferase
HY59_RS02830	COG2823	Periplasmic or secreted lipoprotein
HY59_RS02835	COG5487	UPF0391 membrane protein
HY59_RS02840	COG4667	esterase of the alpha-beta hydrolase superfamily
HY59_RS02845	COG0084	hydrolase, TatD family'
HY59_RS02875	COG3726	membrane protein affecting hemolysin expression
HY59_RS02880	COG0560	Phosphoserine phosphatase
HY59_RS02885	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HY59_RS02895	COG0488	(ABC) transporter
HY59_RS02900	COG0741	lytic transglycosylase activity
HY59_RS02920	COG2207	Transcriptional regulator
HY59_RS02920	COG3708	Transcriptional regulator
HY59_RS02925	COG3045	CreA protein
HY59_RS02930	COG0745	RESPONSE REGULATOR receiver
HY59_RS02935	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HY59_RS02940	COG0527	aspartate kinase activity
HY59_RS02940	COG0460	homoserine dehydrogenase
HY59_RS02950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HY59_RS02965	COG1115	amino acid carrier protein
HY59_RS02975	COG0521	Mo-molybdopterin cofactor biosynthetic process
HY59_RS02985	COG1584	GPR1 FUN34 yaaH family protein
HY59_RS03005	COG0583	DNA-binding transcription factor activity
HY59_RS03015	COG0196	riboflavin kinase activity
HY59_RS03025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HY59_RS03030	COG1047	Peptidyl-prolyl cis-trans
HY59_RS03055	COG2140	Oxalate decarboxylase
HY59_RS03065	COG3716	PTS system mannose fructose sorbose family IID component
HY59_RS03070	COG3715	PTS system
HY59_RS03075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS03090	COG1609	Transcriptional regulator
HY59_RS03100	COG0505	Belongs to the CarA family
HY59_RS03105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HY59_RS03115	COG2731	YhcH YjgK YiaL family protein
HY59_RS03120	COG3265	gluconokinase activity
HY59_RS03125	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS03130	COG1609	Transcriptional regulator
HY59_RS03135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HY59_RS03140	COG2271	Major facilitator Superfamily
HY59_RS03175	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HY59_RS03185	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HY59_RS03190	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HY59_RS03205	COG3493	citrate carrier protein
HY59_RS03215	COG0564	pseudouridine synthase activity
HY59_RS03230	COG0417	DNA replication proofreading
HY59_RS03235	COG0235	Class ii aldolase
HY59_RS03255	COG0586	Pfam SNARE associated Golgi protein
HY59_RS03265	COG1178	ABC-type Fe3 transport system permease component
HY59_RS03280	COG2814	Major facilitator Superfamily
HY59_RS03305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HY59_RS03315	COG0028	Belongs to the TPP enzyme family
HY59_RS03325	COG1609	Transcriptional regulator
HY59_RS03345	COG0768	penicillin binding
HY59_RS03355	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HY59_RS03370	COG0772	Belongs to the SEDS family
HY59_RS03395	COG0849	cell division
HY59_RS03400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HY59_RS03420	COG0494	nUDIX hydrolase
HY59_RS03445	COG1459	type II secretion system
HY59_RS03450	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HY59_RS03455	COG4969	Belongs to the N-Me-Phe pilin family
HY59_RS03470	COG3725	Membrane protein required for beta-lactamase induction
HY59_RS03475	COG3940	Belongs to the glycosyl hydrolase 43 family
HY59_RS03480	COG2211	Major facilitator Superfamily
HY59_RS03485	COG1113	amino acid transport
HY59_RS03490	COG2186	Transcriptional regulator
HY59_RS03495	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HY59_RS03500	COG0508	dehydrogenase complex catalyzes the overall conversion of
HY59_RS03505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HY59_RS03520	COG3064	Membrane
HY59_RS03540	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HY59_RS03555	COG2132	Multicopper oxidase
HY59_RS03560	COG4993	Dehydrogenase
HY59_RS03570	COG0288	reversible hydration of carbon dioxide
HY59_RS03575	COG1131	(ABC) transporter
HY59_RS03580	COG0842	Transport permease protein
HY59_RS03585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS03590	COG0726	polysaccharide deacetylase
HY59_RS03605	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HY59_RS03620	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HY59_RS03625	COG0617	tRNA 3'-terminal CCA addition
HY59_RS03645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HY59_RS03650	COG1643	Atp-dependent helicase
HY59_RS03735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HY59_RS03740	COG4774	siderophore transport
HY59_RS03745	COG1120	ATPase activity
HY59_RS03750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HY59_RS03755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS03775	COG2860	membrane
HY59_RS03800	COG3835	regulator
HY59_RS03815	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HY59_RS03820	COG0024	Methionine aminopeptidase
HY59_RS03830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HY59_RS03855	COG0575	Belongs to the CDS family
HY59_RS03860	COG0750	zinc metalloprotease
HY59_RS03870	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HY59_RS03875	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HY59_RS03910	COG1982	Orn Lys Arg decarboxylase major
HY59_RS03915	COG0346	lactoylglutathione lyase activity
HY59_RS03925	COG4568	rho-dependent transcription termination
HY59_RS03935	COG4681	YaeQ
HY59_RS03940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HY59_RS03945	COG3015	lipoprotein NlpE involved in copper resistance
HY59_RS03955	COG1720	tRNA m6t6A37 methyltransferase activity
HY59_RS03965	COG1464	Belongs to the NlpA lipoprotein family
HY59_RS03970	COG2011	ABC-type metal ion transport system permease component
HY59_RS03980	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HY59_RS04015	COG0656	L-ascorbic acid biosynthetic process
HY59_RS04020	COG0583	DNA-binding transcription factor activity
HY59_RS04025	COG2814	Major facilitator Superfamily
HY59_RS04030	COG3021	interspecies interaction between organisms
HY59_RS04035	COG2226	methyltransferase
HY59_RS04040	COG0741	lytic transglycosylase activity
HY59_RS04040	COG1388	LysM domain
HY59_RS04050	COG2226	methyltransferase
HY59_RS04060	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HY59_RS04080	COG1566	PFAM secretion protein HlyD family protein
HY59_RS04095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HY59_RS04100	COG1960	acyl-CoA dehydrogenase activity
HY59_RS04110	COG0121	glutamine amidotransferase
HY59_RS04115	COG3034	peptidoglycan biosynthetic process
HY59_RS04130	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HY59_RS04135	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HY59_RS04150	COG2991	Protein conserved in bacteria
HY59_RS04160	COG0454	-acetyltransferase
HY59_RS04165	COG2195	Cleaves the N-terminal amino acid of tripeptides
HY59_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS04200	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HY59_RS04215	COG1609	Transcriptional regulator
HY59_RS04260	COG0463	Glycosyl transferase, family 2
HY59_RS04280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HY59_RS04285	COG0791	NLP P60 protein
HY59_RS04290	COG0583	DNA-binding transcription factor activity
HY59_RS04315	COG2207	Transcriptional regulator
HY59_RS04340	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HY59_RS04350	COG0765	amino acid transport
HY59_RS04355	COG0765	amino acid transport
HY59_RS04365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS04375	COG4303	Ethanolamine ammonia lyase large subunit
HY59_RS04385	COG0833	amino acid
HY59_RS04390	COG2040	homocysteine
HY59_RS04395	COG3842	ATPase activity
HY59_RS04405	COG1840	ABC-type Fe3 transport system, periplasmic component
HY59_RS04410	COG2271	Major facilitator Superfamily
HY59_RS04425	COG4521	taurine ABC transporter
HY59_RS04430	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HY59_RS04435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS04440	COG2175	clavaminate synthase activity
HY59_RS04450	COG0113	porphobilinogen synthase activity
HY59_RS04455	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HY59_RS04465	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HY59_RS04495	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS04505	COG1609	Transcriptional regulator
HY59_RS04515	COG1785	Belongs to the alkaline phosphatase family
HY59_RS04525	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HY59_RS04535	COG3416	Protein conserved in bacteria
HY59_RS04540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HY59_RS04550	COG4126	flavin adenine dinucleotide binding
HY59_RS04565	COG1940	carbohydrate kinase activity
HY59_RS04575	COG0419	ATPase involved in DNA repair
HY59_RS04580	COG0420	3'-5' exonuclease activity
HY59_RS04605	COG0366	Alpha amylase catalytic
HY59_RS04610	COG0583	DNA-binding transcription factor activity
HY59_RS04615	COG1335	isochorismatase
HY59_RS04635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS04650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS04655	COG0450	alkyl hydroperoxide reductase
HY59_RS04675	COG1862	Preprotein translocase
HY59_RS04685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HY59_RS04705	COG3248	Nucleoside-binding outer membrane protein
HY59_RS04710	COG4238	major outer membrane lipoprotein
HY59_RS04720	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HY59_RS04720	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HY59_RS04730	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HY59_RS04740	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HY59_RS04745	COG0667	Aldo Keto reductase
HY59_RS04755	COG0142	geranyltranstransferase activity
HY59_RS04775	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HY59_RS04785	COG2814	Major facilitator Superfamily
HY59_RS04790	COG0673	inositol 2-dehydrogenase activity
HY59_RS04795	COG0673	inositol 2-dehydrogenase activity
HY59_RS04810	COG1053	succinate dehydrogenase
HY59_RS04820	COG1053	succinate dehydrogenase
HY59_RS04825	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HY59_RS04830	COG1414	Transcriptional regulator
HY59_RS04840	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HY59_RS04845	COG1845	cytochrome c oxidase, subunit III
HY59_RS04850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HY59_RS04855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HY59_RS04860	COG2223	nitrite transmembrane transporter activity
HY59_RS04865	COG3056	Lipoprotein
HY59_RS04870	COG0271	Belongs to the BolA IbaG family
HY59_RS04890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HY59_RS04895	COG0776	regulation of translation
HY59_RS04900	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HY59_RS04905	COG1555	photosystem II stabilization
HY59_RS04910	COG0824	Thioesterase
HY59_RS04920	COG4533	DNA binding
HY59_RS04935	COG1522	sequence-specific DNA binding
HY59_RS04940	COG1132	(ABC) transporter
HY59_RS04945	COG1132	(ABC) transporter
HY59_RS04950	COG0347	Belongs to the P(II) protein family
HY59_RS04955	COG0004	ammonium transporteR
HY59_RS04960	COG1946	Acyl-CoA thioesterase
HY59_RS04965	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HY59_RS04970	COG3695	enzyme binding
HY59_RS04995	COG2364	Membrane
HY59_RS05000	COG5507	3-demethylubiquinone-9 3-methyltransferase
HY59_RS05010	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HY59_RS05020	COG2182	Extracellular solute-binding protein
HY59_RS05025	COG1175	transmembrane transport
HY59_RS05030	COG3833	ABC-type maltose transport systems, permease component
HY59_RS05035	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HY59_RS05040	COG1874	Beta-galactosidase
HY59_RS05065	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HY59_RS05085	COG0110	maltose O-acetyltransferase activity
HY59_RS05100	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HY59_RS05105	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS05110	COG1309	transcriptional regulator
HY59_RS05115	COG1196	nuclear chromosome segregation
HY59_RS05115	COG3264	Mechanosensitive ion channel
HY59_RS05125	COG3923	Primosomal replication protein n
HY59_RS05130	COG2832	Protein of unknown function (DUF454)
HY59_RS05140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HY59_RS05170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS05175	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HY59_RS05175	COG4651	solute:proton antiporter activity
HY59_RS05180	COG2223	nitrite transmembrane transporter activity
HY59_RS05200	COG3735	TraB family
HY59_RS05210	COG1285	pathogenesis
HY59_RS05220	COG1609	Transcriptional regulator
HY59_RS05225	COG0477	Major facilitator Superfamily
HY59_RS05235	COG1585	Membrane protein implicated in regulation of membrane protease activity
HY59_RS05240	COG0330	HflC and HflK could
HY59_RS05245	COG4619	ABC transporter
HY59_RS05250	COG0390	transport system, permease component
HY59_RS05255	COG3118	belongs to the thioredoxin family
HY59_RS05260	COG0300	oxidoreductase activity
HY59_RS05265	COG2755	lipolytic protein G-D-S-L family
HY59_RS05270	COG4181	ATPase activity
HY59_RS05275	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HY59_RS05295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HY59_RS05300	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HY59_RS05310	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HY59_RS05320	COG2501	S4 domain
HY59_RS05395	COG1448	Aminotransferase
HY59_RS05400	COG0833	amino acid
HY59_RS05410	COG3710	Transcriptional regulator
HY59_RS05415	COG0531	amino acid
HY59_RS05425	COG3104	oligopeptide transport
HY59_RS05435	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS05440	COG0549	Belongs to the carbamate kinase family
HY59_RS05445	COG1304	FMN binding
HY59_RS05450	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HY59_RS05460	COG0666	response to abiotic stimulus
HY59_RS05470	COG0583	DNA-binding transcription factor activity
HY59_RS05490	COG1129	ABC transporter
HY59_RS05495	COG4211	Belongs to the binding-protein-dependent transport system permease family
HY59_RS05500	COG3706	GGDEF domain
HY59_RS05540	COG0583	DNA-binding transcription factor activity
HY59_RS05545	COG2190	(PTS) system
HY59_RS05545	COG1263	PTS System
HY59_RS05545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS05550	COG2723	6-phospho-beta-galactosidase activity
HY59_RS05555	COG3711	transcriptional antiterminator
HY59_RS05595	COG1566	PFAM secretion protein HlyD family protein
HY59_RS05600	COG1120	ATPase activity
HY59_RS05605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS05630	COG1473	amidohydrolase
HY59_RS05635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS05640	COG0667	Aldo Keto reductase
HY59_RS05685	COG0531	amino acid
HY59_RS05695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HY59_RS05700	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS05715	COG1113	amino acid transport
HY59_RS05720	COG2211	Major facilitator Superfamily
HY59_RS05730	COG0673	inositol 2-dehydrogenase activity
HY59_RS05745	COG0668	transmembrane transport
HY59_RS05750	COG0477	Major facilitator Superfamily
HY59_RS05765	COG0778	Nitroreductase
HY59_RS05770	COG2315	Protein conserved in bacteria
HY59_RS05790	COG4774	siderophore transport
HY59_RS05815	COG3698	Phosphodiester glycosidase
HY59_RS05825	COG4166	transmembrane transport
HY59_RS05835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS05840	COG4608	Belongs to the ABC transporter superfamily
HY59_RS05845	COG0444	Belongs to the ABC transporter superfamily
HY59_RS05850	COG0154	amidase activity
HY59_RS05865	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
HY59_RS05870	COG0765	amino acid transport
HY59_RS05875	COG4215	(ABC) transporter
HY59_RS05885	COG4221	oxidoreductase activity
HY59_RS05890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HY59_RS05895	COG4608	Belongs to the ABC transporter superfamily
HY59_RS05900	COG0444	Belongs to the ABC transporter superfamily
HY59_RS05905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS05910	COG0601	transmembrane transport
HY59_RS05940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HY59_RS05945	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS05950	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS05955	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS05960	COG1129	ABC transporter
HY59_RS05970	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS05975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HY59_RS05980	COG2390	Transcriptional regulator
HY59_RS05985	COG3959	Transketolase, thiamine diphosphate binding domain
HY59_RS05990	COG3958	Transketolase
HY59_RS05995	COG2977	Belongs to the P-Pant transferase superfamily
HY59_RS06000	COG4771	TonB-dependent receptor
HY59_RS06005	COG2382	esterase
HY59_RS06010	COG3251	PFAM MbtH domain protein
HY59_RS06015	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HY59_RS06015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HY59_RS06020	COG1120	ATPase activity
HY59_RS06025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS06030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS06040	COG4592	Periplasmic binding protein
HY59_RS06045	COG1169	isochorismate synthase
HY59_RS06050	COG1021	2,3-dihydroxybenzoate-AMP ligase
HY59_RS06055	COG3433	isochorismatase activity
HY59_RS06055	COG1535	isochorismatase
HY59_RS06060	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS06075	COG1966	Carbon starvation protein
HY59_RS06080	COG2879	small protein
HY59_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS06090	COG0371	Dehydrogenase
HY59_RS06095	COG1129	ABC transporter
HY59_RS06100	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS06130	COG2271	Major facilitator Superfamily
HY59_RS06135	COG0483	inositol monophosphate 1-phosphatase activity
HY59_RS06145	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS06155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HY59_RS06170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HY59_RS06180	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS06185	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS06190	COG1129	ABC transporter
HY59_RS06205	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HY59_RS06215	COG0436	Aminotransferase
HY59_RS06220	COG1475	DNA binding
HY59_RS06225	COG3969	phosphoadenosine phosphosulfate
HY59_RS06230	COG0583	DNA-binding transcription factor activity
HY59_RS06235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HY59_RS06245	COG3634	alkyl hydroperoxide reductase activity
HY59_RS06255	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HY59_RS06265	COG3719	Belongs to the RNase T2 family
HY59_RS06270	COG3069	C4-dicarboxylate transmembrane transporter activity
HY59_RS06290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HY59_RS06305	COG0583	DNA-binding transcription factor activity
HY59_RS06320	COG1686	Belongs to the peptidase S11 family
HY59_RS06325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HY59_RS06330	COG0772	Belongs to the SEDS family
HY59_RS06335	COG0768	penicillin binding
HY59_RS06345	COG0799	negative regulation of ribosome biogenesis
HY59_RS06350	COG0406	alpha-ribazole phosphatase activity
HY59_RS06360	COG1466	dna polymerase III delta subunit
HY59_RS06375	COG2888	peptidyl-tyrosine sulfation
HY59_RS06380	COG1126	abc transporter atp-binding protein
HY59_RS06385	COG0765	amino acid transport
HY59_RS06390	COG0765	amino acid transport
HY59_RS06405	COG4535	Mg2 and Co2 transporter CorC
HY59_RS06410	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HY59_RS06415	COG1702	phosphate starvation-inducible protein PhoH
HY59_RS06425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HY59_RS06465	COG0367	asparagine synthase
HY59_RS06470	COG0647	UMP catabolic process
HY59_RS06480	COG1940	carbohydrate kinase activity
HY59_RS06480	COG1846	Transcriptional regulator
HY59_RS06485	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HY59_RS06515	COG0735	belongs to the Fur family
HY59_RS06530	COG0596	Alpha beta hydrolase
HY59_RS06535	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HY59_RS06540	COG0033	Phosphoglucomutase
HY59_RS06545	COG0531	amino acid
HY59_RS06550	COG1982	Orn Lys Arg decarboxylase major
HY59_RS06555	COG0745	RESPONSE REGULATOR receiver
HY59_RS06560	COG2205	protein histidine kinase activity
HY59_RS06590	COG0415	Belongs to the DNA photolyase family
HY59_RS06600	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HY59_RS06605	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HY59_RS06610	COG1984	allophanate hydrolase subunit 2
HY59_RS06640	COG0372	Belongs to the citrate synthase family
HY59_RS06645	COG2009	succinate dehydrogenase
HY59_RS06650	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HY59_RS06655	COG1053	succinate dehydrogenase
HY59_RS06660	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HY59_RS06665	COG0567	Dehydrogenase, E1 component
HY59_RS06670	COG0508	dehydrogenase complex catalyzes the overall conversion of
HY59_RS06680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HY59_RS06685	COG1271	oxidase subunit
HY59_RS06690	COG1294	oxidase, subunit
HY59_RS06695	COG4890	Cyd operon protein YbgT
HY59_RS06700	COG3790	cyd operon protein YbgE
HY59_RS06705	COG0824	Thioesterase
HY59_RS06710	COG0811	peptide transport
HY59_RS06715	COG0848	biopolymer transport protein
HY59_RS06720	COG3064	Membrane
HY59_RS06720	COG3064	Membrane
HY59_RS06730	COG2885	chlorophyll binding
HY59_RS06735	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HY59_RS06755	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HY59_RS06760	COG3201	nicotinamide mononucleotide transporter
HY59_RS06770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HY59_RS06780	COG2017	converts alpha-aldose to the beta-anomer
HY59_RS06790	COG1085	galactose-1-phosphate uridylyltransferase
HY59_RS06795	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HY59_RS06800	COG1119	ATPase activity
HY59_RS06805	COG2005	Transcriptional regulator
HY59_RS06805	COG3585	molybdate ion transport
HY59_RS06815	COG0725	ABC transporter, periplasmic molybdate-binding protein
HY59_RS06820	COG4149	molybdate abc transporter
HY59_RS06830	COG0561	phosphatase activity
HY59_RS06850	COG4232	protein-disulfide reductase activity
HY59_RS06875	COG4677	pectinesterase activity
HY59_RS06910	COG1881	PFAM PEBP family protein
HY59_RS06915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HY59_RS06930	COG2226	methyltransferase
HY59_RS06950	COG0642	Histidine kinase
HY59_RS06955	COG0745	RESPONSE REGULATOR receiver
HY59_RS06975	COG0521	Mo-molybdopterin cofactor biosynthetic process
HY59_RS06985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HY59_RS06990	COG0314	molybdopterin synthase activity
HY59_RS06995	COG0670	Belongs to the BI1 family
HY59_RS07000	COG0392	lysyltransferase activity
HY59_RS07005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HY59_RS07010	COG3568	Endonuclease Exonuclease Phosphatase
HY59_RS07020	COG0842	Transport permease protein
HY59_RS07025	COG0842	Transport permease protein
HY59_RS07030	COG1131	(ABC) transporter
HY59_RS07035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS07040	COG1309	transcriptional regulator
HY59_RS07045	COG0513	Belongs to the DEAD box helicase family
HY59_RS07055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HY59_RS07065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HY59_RS07090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HY59_RS07100	COG0668	transmembrane transport
HY59_RS07105	COG1126	abc transporter atp-binding protein
HY59_RS07110	COG0765	amino acid transport
HY59_RS07115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS07130	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HY59_RS07135	COG2194	sulfuric ester hydrolase activity
HY59_RS07145	COG1321	iron dependent repressor
HY59_RS07150	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HY59_RS07160	COG2723	6-phospho-beta-galactosidase activity
HY59_RS07165	COG2188	Transcriptional regulator
HY59_RS07170	COG1376	ErfK ybiS ycfS ynhG family protein
HY59_RS07175	COG2365	Tyrosine phosphatase family
HY59_RS07180	COG0488	(ABC) transporter
HY59_RS07195	COG2271	Major facilitator Superfamily
HY59_RS07200	COG1609	Transcriptional regulator
HY59_RS07210	COG0561	phosphatase activity
HY59_RS07215	COG1882	Formate acetyltransferase
HY59_RS07220	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HY59_RS07225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HY59_RS07230	COG0303	'Molybdopterin
HY59_RS07240	COG1446	asparaginase
HY59_RS07250	COG0747	negative chemotaxis
HY59_RS07270	COG2223	nitrite transmembrane transporter activity
HY59_RS07280	COG2133	pyrroloquinoline quinone binding
HY59_RS07285	COG0625	glutathione transferase activity
HY59_RS07290	COG1686	Belongs to the peptidase S11 family
HY59_RS07295	COG1349	DNA-binding transcription factor activity
HY59_RS07300	COG0671	phosphoesterase, PA-phosphatase related
HY59_RS07305	COG2814	Major facilitator Superfamily
HY59_RS07310	COG0561	phosphatase activity
HY59_RS07315	COG0738	Major facilitator superfamily
HY59_RS07320	COG3226	Transcriptional regulator
HY59_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS07350	COG4695	Portal protein
HY59_RS07410	COG0778	Nitroreductase
HY59_RS07425	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HY59_RS07430	COG3842	ATPase activity
HY59_RS07435	COG1176	ABC-type spermidine putrescine transport system, permease component I
HY59_RS07440	COG1177	transmembrane transport
HY59_RS07455	COG0745	RESPONSE REGULATOR receiver
HY59_RS07460	COG5002	protein histidine kinase activity
HY59_RS07465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS07470	COG4160	amino acid transport
HY59_RS07475	COG4215	(ABC) transporter
HY59_RS07480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS07485	COG1126	abc transporter atp-binding protein
HY59_RS07500	COG2067	long-chain fatty acid transport protein
HY59_RS07510	COG3023	N-Acetylmuramoyl-L-alanine amidase
HY59_RS07515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HY59_RS07520	COG0702	epimerase
HY59_RS07525	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HY59_RS07530	COG0028	Belongs to the TPP enzyme family
HY59_RS07540	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HY59_RS07550	COG2431	L-lysine efflux transmembrane transporter activity
HY59_RS07560	COG3593	DNA synthesis involved in DNA repair
HY59_RS07565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS07575	COG1278	Cold shock
HY59_RS07585	COG0542	response to heat
HY59_RS07590	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HY59_RS07600	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HY59_RS07605	COG4988	ABC transporter
HY59_RS07610	COG0492	ferredoxin-NADP+ reductase activity
HY59_RS07620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HY59_RS07620	COG1674	ftsk spoiiie
HY59_RS07630	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HY59_RS07640	COG0243	molybdopterin cofactor binding
HY59_RS07645	COG0437	4 iron, 4 sulfur cluster binding
HY59_RS07650	COG3302	dmso reductase anchor subunit
HY59_RS07655	COG0477	Major facilitator Superfamily
HY59_RS07660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS07665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HY59_RS07670	COG3959	Transketolase, thiamine diphosphate binding domain
HY59_RS07685	COG1737	Transcriptional regulator
HY59_RS07690	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HY59_RS07695	COG1882	Formate acetyltransferase
HY59_RS07700	COG2116	formate transmembrane transporter activity
HY59_RS07705	COG1944	ATP diphosphatase activity
HY59_RS07710	COG2323	membrane
HY59_RS07730	COG0539	negative regulation of cytoplasmic translation
HY59_RS07740	COG0658	competence protein
HY59_RS07740	COG2333	competence protein COMEC
HY59_RS07755	COG3214	Protein conserved in bacteria
HY59_RS07770	COG3173	Aminoglycoside phosphotransferase
HY59_RS07775	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HY59_RS07780	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HY59_RS07790	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HY59_RS07800	COG2989	Protein conserved in bacteria
HY59_RS07805	COG3108	Peptidase M15
HY59_RS07810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HY59_RS07815	COG1448	Aminotransferase
HY59_RS07820	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HY59_RS07830	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HY59_RS07835	COG0582	viral genome integration into host DNA
HY59_RS07900	COG1192	Involved in chromosome partitioning
HY59_RS08020	COG3772	lysozyme
HY59_RS08185	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HY59_RS08190	COG2135	peptidase activity
HY59_RS08195	COG0308	aminopeptidase N
HY59_RS08200	COG1116	anion transmembrane transporter activity
HY59_RS08205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS08215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HY59_RS08220	COG0431	NADPH-dependent FMN reductase
HY59_RS08235	COG3217	Mosc domain protein beta barrel domain protein
HY59_RS08235	COG0633	Ferredoxin
HY59_RS08245	COG0488	(ABC) transporter
HY59_RS08250	COG2995	paraquat-inducible protein a
HY59_RS08255	COG3008	intermembrane lipid transfer
HY59_RS08255	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HY59_RS08260	COG3009	Protein conserved in bacteria
HY59_RS08275	COG1067	ATP-dependent peptidase activity
HY59_RS08295	COG3070	regulator of competence-specific genes
HY59_RS08300	COG1289	transmembrane transporter activity
HY59_RS08305	COG3304	Inner membrane component domain
HY59_RS08310	COG0210	DNA helicase
HY59_RS08320	COG1832	CoA-binding protein
HY59_RS08335	COG1881	PFAM PEBP family protein
HY59_RS08355	COG0670	Belongs to the BI1 family
HY59_RS08410	COG0531	amino acid
HY59_RS08415	COG2235	arginine
HY59_RS08420	COG0549	Belongs to the carbamate kinase family
HY59_RS08455	COG1309	transcriptional regulator
HY59_RS08485	COG0456	acetyltransferase
HY59_RS08545	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HY59_RS08555	COG2351	hydroxyisourate hydrolase activity
HY59_RS08560	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS08565	COG1953	Uracil, thiamine, allantoin
HY59_RS08620	COG0765	amino acid transport
HY59_RS08630	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HY59_RS08640	COG3706	GGDEF domain
HY59_RS08645	COG2207	Transcriptional regulator
HY59_RS08655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HY59_RS08660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HY59_RS08665	COG1882	Formate acetyltransferase
HY59_RS08670	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HY59_RS08675	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HY59_RS08680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HY59_RS08680	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS08680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS08685	COG0473	3-isopropylmalate dehydrogenase activity
HY59_RS08690	COG0583	DNA-binding transcription factor activity
HY59_RS08695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HY59_RS08700	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS08705	COG1396	sequence-specific DNA binding
HY59_RS08705	COG1917	Cupin 2, conserved barrel domain protein
HY59_RS08710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HY59_RS08715	COG0174	glutamine synthetase
HY59_RS08720	COG0531	amino acid
HY59_RS08730	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS08735	COG1733	regulation of RNA biosynthetic process
HY59_RS08765	COG3729	General stress protein
HY59_RS08770	COG2233	PERMEase
HY59_RS08790	COG0251	oxidation-reduction process
HY59_RS08805	COG1309	transcriptional regulator
HY59_RS08820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HY59_RS08830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HY59_RS08850	COG1702	phosphate starvation-inducible protein PhoH
HY59_RS08855	COG2814	Major facilitator Superfamily
HY59_RS08865	COG4772	TonB-dependent receptor
HY59_RS08900	COG3381	protein complex oligomerization
HY59_RS08930	COG5645	(Lipo)protein
HY59_RS08945	COG1560	Kdo2-lipid A biosynthetic process
HY59_RS08990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HY59_RS09010	COG2814	Major facilitator Superfamily
HY59_RS09015	COG0583	DNA-binding transcription factor activity
HY59_RS09020	COG1530	ribonuclease E activity
HY59_RS09030	COG0424	maF-like protein
HY59_RS09035	COG1399	metal-binding, possibly nucleic acid-binding protein
HY59_RS09055	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HY59_RS09070	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HY59_RS09075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HY59_RS09080	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HY59_RS09090	COG0470	DNA polymerase III
HY59_RS09095	COG0084	hydrolase, TatD family'
HY59_RS09105	COG4773	Receptor
HY59_RS09110	COG0537	adenosine 5'-monophosphoramidase activity
HY59_RS09115	COG5633	Lipoprotein
HY59_RS09140	COG1252	NADH dehydrogenase
HY59_RS09145	COG3134	Outer membrane lipoprotein
HY59_RS09155	COG1309	transcriptional regulator
HY59_RS09165	COG1376	ErfK ybiS ycfS ynhG family protein
HY59_RS09165	COG1388	LysM domain
HY59_RS09170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HY59_RS09175	COG4591	ABC-type transport system involved in lipoprotein release permease component
HY59_RS09180	COG1136	(ABC) transporter
HY59_RS09185	COG4591	ABC-type transport system involved in lipoprotein release permease component
HY59_RS09195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HY59_RS09200	COG2390	Transcriptional regulator
HY59_RS09205	COG0149	triose-phosphate isomerase activity
HY59_RS09215	COG3395	kinase activity
HY59_RS09230	COG0698	ribose 5-phosphate isomerase
HY59_RS09235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HY59_RS09240	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HY59_RS09250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HY59_RS09255	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HY59_RS09260	COG0745	RESPONSE REGULATOR receiver
HY59_RS09265	COG0318	PFAM AMP-dependent synthetase and ligase
HY59_RS09280	COG1177	transmembrane transport
HY59_RS09300	COG1943	Transposase
HY59_RS09305	COG2850	peptidyl-arginine hydroxylation
HY59_RS09310	COG2205	protein histidine kinase activity
HY59_RS09320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HY59_RS09340	COG1187	pseudouridine synthase activity
HY59_RS09345	COG0538	isocitrate dehydrogenase activity
HY59_RS09350	COG0321	lipoyl(octanoyl) transferase activity
HY59_RS09350	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HY59_RS09355	COG2814	Major facilitator Superfamily
HY59_RS09375	COG3122	Protein conserved in bacteria
HY59_RS09410	COG3706	GGDEF domain
HY59_RS09415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HY59_RS09420	COG4772	TonB-dependent receptor
HY59_RS09425	COG3712	iron ion homeostasis
HY59_RS09430	COG1595	DNA-templated transcription, initiation
HY59_RS09435	COG1560	Kdo2-lipid A biosynthetic process
HY59_RS09445	COG3182	Iron-regulated membrane protein
HY59_RS09450	COG2199	diguanylate cyclase activity
HY59_RS09450	COG2203	Gaf domain
HY59_RS09455	COG3042	response to heat
HY59_RS09460	COG3189	MarR family transcriptional regulator
HY59_RS09465	COG1683	Conserved Protein
HY59_RS09470	COG0504	CTP synthase activity
HY59_RS09475	COG2807	transmembrane transport
HY59_RS09480	COG2207	Transcriptional regulator
HY59_RS09490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HY59_RS09495	COG0859	PFAM glycosyl transferase family 9
HY59_RS09500	COG1403	HNH endonuclease
HY59_RS09505	COG4580	involved in the transport of maltose and maltodextrins
HY59_RS09520	COG2766	serine protein kinase
HY59_RS09525	COG3713	MltA-interacting MipA family protein
HY59_RS09530	COG0656	L-ascorbic acid biosynthetic process
HY59_RS09535	COG0471	metal ion transport
HY59_RS09555	COG3139	Protein of unknown function (DUF1315)
HY59_RS09565	COG1335	isochorismatase
HY59_RS09570	COG0252	asparaginase activity
HY59_RS09575	COG0616	signal peptide processing
HY59_RS09580	COG0778	Nitroreductase
HY59_RS09595	COG2188	Transcriptional regulator
HY59_RS09600	COG0709	Synthesizes selenophosphate from selenide and ATP
HY59_RS09605	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HY59_RS09620	COG0494	nUDIX hydrolase
HY59_RS09625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HY59_RS09630	COG2897	thiosulfate sulfurtransferase activity
HY59_RS09635	COG4136	ATPase activity
HY59_RS09640	COG4135	transport system, permease component
HY59_RS09645	COG4134	Bacterial extracellular solute-binding protein
HY59_RS09650	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HY59_RS09655	COG0398	Pfam SNARE associated Golgi protein
HY59_RS09660	COG0398	Pfam SNARE associated Golgi protein
HY59_RS09665	COG0708	Exodeoxyribonuclease III
HY59_RS09675	COG3138	arginine N-succinyltransferase
HY59_RS09685	COG3724	N-succinylarginine dihydrolase activity
HY59_RS09695	COG3678	ATP-independent chaperone mediated protein folding
HY59_RS09700	COG0322	excinuclease ABC activity
HY59_RS09710	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HY59_RS09715	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS09720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS09725	COG1447	Phosphotransferase system cellobiose-specific component IIA
HY59_RS09730	COG2169	Transcriptional regulator
HY59_RS09730	COG1917	Cupin 2, conserved barrel domain protein
HY59_RS09735	COG1486	melibiose metabolic process
HY59_RS09745	COG0753	catalase activity
HY59_RS09755	COG1823	symporter activity
HY59_RS09760	COG1988	membrane-bound metal-dependent
HY59_RS09765	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS09770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HY59_RS09790	COG0038	chloride channel
HY59_RS09805	COG0727	PFAM Uncharacterised protein family (UPF0153)
HY59_RS09810	COG3047	cAMP biosynthetic process
HY59_RS09835	COG0583	DNA-binding transcription factor activity
HY59_RS09840	COG1063	alcohol dehydrogenase
HY59_RS09845	COG1846	Transcriptional regulator
HY59_RS09865	COG0512	Glutamine amidotransferase of anthranilate synthase
HY59_RS09865	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HY59_RS09870	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HY59_RS09880	COG0009	L-threonylcarbamoyladenylate synthase
HY59_RS09890	COG1187	pseudouridine synthase activity
HY59_RS09895	COG2211	Major facilitator Superfamily
HY59_RS09900	COG1472	Belongs to the glycosyl hydrolase 3 family
HY59_RS09905	COG2207	Transcriptional regulator
HY59_RS09910	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HY59_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS09920	COG0616	signal peptide processing
HY59_RS09940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HY59_RS09950	COG0671	phosphoesterase, PA-phosphatase related
HY59_RS09955	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HY59_RS09960	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HY59_RS09970	COG0023	Translation Initiation Factor
HY59_RS09980	COG1349	DNA-binding transcription factor activity
HY59_RS09995	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HY59_RS09995	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HY59_RS10000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HY59_RS10030	COG2986	histidine ammonia-lyase
HY59_RS10035	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HY59_RS10050	COG4171	peptide transport system, permease
HY59_RS10075	COG0702	epimerase
HY59_RS10090	COG1473	amidohydrolase
HY59_RS10105	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HY59_RS10110	COG1842	Phage shock protein A
HY59_RS10120	COG1983	PspC domain protein
HY59_RS10130	COG3106	COG3106 Predicted ATPase
HY59_RS10145	COG3180	Ammonia monooxygenase
HY59_RS10150	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HY59_RS10155	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS10160	COG2866	Carboxypeptidase
HY59_RS10165	COG4166	transmembrane transport
HY59_RS10175	COG5562	phage envelope protein
HY59_RS10195	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HY59_RS10205	COG0583	DNA-binding transcription factor activity
HY59_RS10210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HY59_RS10215	COG1917	Cupin 2, conserved barrel domain protein
HY59_RS10230	COG0702	epimerase
HY59_RS10240	COG0667	Aldo Keto reductase
HY59_RS10245	COG0656	L-ascorbic acid biosynthetic process
HY59_RS10260	COG3775	system Galactitol-specific IIC component
HY59_RS10265	COG1069	ribulokinase activity
HY59_RS10270	COG1063	alcohol dehydrogenase
HY59_RS10275	COG2188	Transcriptional regulator
HY59_RS10295	COG1063	alcohol dehydrogenase
HY59_RS10335	COG5002	protein histidine kinase activity
HY59_RS10365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HY59_RS10370	COG1064	alcohol dehydrogenase
HY59_RS10375	COG2207	Transcriptional regulator
HY59_RS10380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HY59_RS10405	COG0583	DNA-binding transcription factor activity
HY59_RS10410	COG0583	DNA-binding transcription factor activity
HY59_RS10415	COG1902	pentaerythritol trinitrate reductase activity
HY59_RS10425	COG2801	Transposase and inactivated derivatives
HY59_RS10440	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HY59_RS10475	COG2207	Transcriptional regulator
HY59_RS10480	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS10485	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS10490	COG2378	regulation of single-species biofilm formation
HY59_RS10495	COG0673	inositol 2-dehydrogenase activity
HY59_RS10500	COG1349	DNA-binding transcription factor activity
HY59_RS10510	COG0513	Belongs to the DEAD box helicase family
HY59_RS10520	COG0589	response to stress
HY59_RS10530	COG0674	pyruvate-flavodoxin oxidoreductase activity
HY59_RS10530	COG1013	pyruvate-flavodoxin oxidoreductase activity
HY59_RS10530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HY59_RS10530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HY59_RS10535	COG3042	response to heat
HY59_RS10540	COG3187	Heat shock protein
HY59_RS10545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HY59_RS10550	COG0586	Pfam SNARE associated Golgi protein
HY59_RS10555	COG2911	Protein conserved in bacteria
HY59_RS10565	COG3784	Protein of unknown function (DUF1318)
HY59_RS10570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS10570	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS10575	COG2814	Major facilitator Superfamily
HY59_RS10580	COG2207	Transcriptional regulator
HY59_RS10585	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS10610	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS10610	COG2030	dehydratase
HY59_RS10615	COG3396	Phenylacetate-CoA oxygenase
HY59_RS10620	COG3460	Phenylacetate-CoA oxygenase
HY59_RS10625	COG3396	Phenylacetate-CoA oxygenase
HY59_RS10630	COG2151	metal-sulfur cluster biosynthetic enzyme
HY59_RS10635	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HY59_RS10640	COG1024	Enoyl-CoA hydratase
HY59_RS10645	COG1024	Enoyl-CoA hydratase
HY59_RS10650	COG1250	3-hydroxyacyl-CoA dehydrogenase
HY59_RS10655	COG2050	protein possibly involved in aromatic compounds catabolism
HY59_RS10660	COG0183	Belongs to the thiolase family
HY59_RS10665	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HY59_RS10670	COG3327	negative regulation of DNA-templated transcription, initiation
HY59_RS10675	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HY59_RS10685	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HY59_RS10695	COG1643	Atp-dependent helicase
HY59_RS10700	COG4122	O-methyltransferase activity
HY59_RS10725	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HY59_RS10730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HY59_RS10735	COG3138	arginine N-succinyltransferase
HY59_RS10740	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS10745	COG3724	N-succinylarginine dihydrolase activity
HY59_RS10750	COG2988	succinylglutamate desuccinylase activity
HY59_RS10755	COG1113	amino acid transport
HY59_RS10760	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HY59_RS10765	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS10770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HY59_RS10780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS10835	COG3459	Glycosyltransferase 36 associated
HY59_RS10840	COG3038	cytochrome b561
HY59_RS10865	COG0583	DNA-binding transcription factor activity
HY59_RS10870	COG3485	protocatechuate 3,4-dioxygenase
HY59_RS10875	COG3485	protocatechuate 3,4-dioxygenase
HY59_RS10880	COG5383	Protein conserved in bacteria
HY59_RS10885	COG2272	Belongs to the type-B carboxylesterase lipase family
HY59_RS10895	COG1335	isochorismatase
HY59_RS10900	COG0436	Aminotransferase
HY59_RS10915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HY59_RS10920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HY59_RS10925	COG1275	C4-dicarboxylate transporter malic acid transport protein
HY59_RS10930	COG0500	methyltransferase
HY59_RS10935	COG2195	Cleaves the N-terminal amino acid of tripeptides
HY59_RS10940	COG0747	negative chemotaxis
HY59_RS10950	COG0697	spore germination
HY59_RS10955	COG2207	Transcriptional regulator
HY59_RS10960	COG3135	benzoate transporter
HY59_RS10965	COG1396	sequence-specific DNA binding
HY59_RS10970	COG0826	peptidase U32
HY59_RS10990	COG1294	oxidase, subunit
HY59_RS10995	COG1271	oxidase subunit
HY59_RS11000	COG1454	alcohol dehydrogenase
HY59_RS11015	COG0277	FAD linked oxidase domain protein
HY59_RS11025	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HY59_RS11035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HY59_RS11040	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HY59_RS11045	COG3842	ATPase activity
HY59_RS11050	COG1176	ABC-type spermidine putrescine transport system, permease component I
HY59_RS11055	COG1177	transmembrane transport
HY59_RS11060	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS11105	COG2267	carboxylic ester hydrolase activity
HY59_RS11110	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS11115	COG0747	negative chemotaxis
HY59_RS11125	COG3238	Protein conserved in bacteria
HY59_RS11130	COG1247	-acetyltransferase
HY59_RS11140	COG2130	NADP-dependent
HY59_RS11160	COG4772	TonB-dependent receptor
HY59_RS11195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS11200	COG1473	amidohydrolase
HY59_RS11205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS11220	COG0765	amino acid transport
HY59_RS11225	COG1126	abc transporter atp-binding protein
HY59_RS11245	COG0625	glutathione transferase activity
HY59_RS11260	COG2211	Major facilitator Superfamily
HY59_RS11285	COG1846	Transcriptional regulator
HY59_RS11290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HY59_RS11295	COG3842	ATPase activity
HY59_RS11300	COG1840	ABC-type Fe3 transport system, periplasmic component
HY59_RS11305	COG1178	ABC-type Fe3 transport system permease component
HY59_RS11310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HY59_RS11325	COG0583	DNA-binding transcription factor activity
HY59_RS11335	COG2181	nitrate reductase activity
HY59_RS11340	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HY59_RS11345	COG1140	nitrate reductase beta subunit
HY59_RS11350	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HY59_RS11370	COG1414	Transcriptional regulator
HY59_RS11375	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS11380	COG4829	muconolactone delta-isomerase
HY59_RS11385	COG3485	protocatechuate 3,4-dioxygenase
HY59_RS11410	COG0697	spore germination
HY59_RS11415	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS11415	COG0243	molybdopterin cofactor binding
HY59_RS11420	COG0243	molybdopterin cofactor binding
HY59_RS11420	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS11425	COG0437	4 iron, 4 sulfur cluster binding
HY59_RS11430	COG2864	formate dehydrogenase
HY59_RS11450	COG2814	Major facilitator Superfamily
HY59_RS11460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS11470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS11485	COG1064	alcohol dehydrogenase
HY59_RS11500	COG0488	(ABC) transporter
HY59_RS11525	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS11535	COG0179	Fumarylacetoacetate (FAA) hydrolase
HY59_RS11550	COG0251	oxidation-reduction process
HY59_RS11555	COG1695	Transcriptional regulator
HY59_RS11580	COG1764	response to oxidative stress
HY59_RS11590	COG3781	membrane
HY59_RS11595	COG0243	molybdopterin cofactor binding
HY59_RS11610	COG0583	DNA-binding transcription factor activity
HY59_RS11615	COG2271	Major facilitator Superfamily
HY59_RS11630	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HY59_RS11650	COG1116	anion transmembrane transporter activity
HY59_RS11650	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HY59_RS11660	COG3665	Urea carboxylase-associated protein
HY59_RS11665	COG0439	Biotin carboxylase
HY59_RS11680	COG2814	Major facilitator Superfamily
HY59_RS11685	COG1869	D-ribose catabolic process
HY59_RS11690	COG2814	Major facilitator Superfamily
HY59_RS11695	COG1105	Belongs to the carbohydrate kinase PfkB family
HY59_RS11705	COG0277	FAD linked oxidase domain protein
HY59_RS11720	COG0519	Catalyzes the synthesis of GMP from XMP
HY59_RS11720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HY59_RS11725	COG0596	Alpha beta hydrolase
HY59_RS11735	COG2205	protein histidine kinase activity
HY59_RS11745	COG0076	glutamate decarboxylase activity
HY59_RS11750	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HY59_RS11755	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HY59_RS11760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS11765	COG1116	anion transmembrane transporter activity
HY59_RS11770	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HY59_RS11790	COG3706	GGDEF domain
HY59_RS11795	COG4106	trans-aconitate 2-methyltransferase activity
HY59_RS11815	COG1396	sequence-specific DNA binding
HY59_RS11820	COG3550	peptidyl-serine autophosphorylation
HY59_RS11825	COG1649	PFAM Uncharacterised BCR, COG1649
HY59_RS11870	COG3158	transport of potassium into the cell
HY59_RS11890	COG0436	Aminotransferase
HY59_RS11895	COG0697	spore germination
HY59_RS11910	COG2814	Major facilitator Superfamily
HY59_RS11915	COG0583	DNA-binding transcription factor activity
HY59_RS11925	COG0110	maltose O-acetyltransferase activity
HY59_RS11980	COG2207	Transcriptional regulator
HY59_RS11985	COG4628	conserved protein (DUF2132)
HY59_RS12005	COG2011	ABC-type metal ion transport system permease component
HY59_RS12010	COG2070	2-Nitropropane dioxygenase
HY59_RS12060	COG0583	DNA-binding transcription factor activity
HY59_RS12080	COG2199	diguanylate cyclase activity
HY59_RS12095	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS12100	COG0583	DNA-binding transcription factor activity
HY59_RS12110	COG0039	L-malate dehydrogenase activity
HY59_RS12135	COG1846	Transcriptional regulator
HY59_RS12150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HY59_RS12155	COG2211	Major facilitator Superfamily
HY59_RS12165	COG1609	Transcriptional regulator
HY59_RS12175	COG0386	Belongs to the glutathione peroxidase family
HY59_RS12200	COG0477	Major facilitator Superfamily
HY59_RS12210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HY59_RS12215	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HY59_RS12230	COG0159	tryptophan synthase activity
HY59_RS12245	COG1609	Transcriptional regulator
HY59_RS12255	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS12270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HY59_RS12280	COG4771	TonB-dependent receptor
HY59_RS12285	COG3391	amine dehydrogenase activity
HY59_RS12295	COG0789	Transcriptional regulator
HY59_RS12310	COG0697	spore germination
HY59_RS12315	COG2814	Major facilitator Superfamily
HY59_RS12345	COG0683	leucine binding
HY59_RS12350	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HY59_RS12400	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HY59_RS12410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HY59_RS12420	COG0789	Transcriptional regulator
HY59_RS12425	COG3272	Protein of unknown function (DUF1722)
HY59_RS12430	COG3477	response to acidic pH
HY59_RS12435	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HY59_RS12460	COG2223	nitrite transmembrane transporter activity
HY59_RS12465	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HY59_RS12490	COG0339	signal peptide processing
HY59_RS12500	COG4221	oxidoreductase activity
HY59_RS12505	COG1802	Transcriptional regulator
HY59_RS12515	COG0246	Mannitol dehydrogenase
HY59_RS12520	COG0477	Major facilitator Superfamily
HY59_RS12525	COG1063	alcohol dehydrogenase
HY59_RS12530	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS12535	COG2271	Major facilitator Superfamily
HY59_RS12550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HY59_RS12565	COG0243	molybdopterin cofactor binding
HY59_RS12570	COG3302	dmso reductase anchor subunit
HY59_RS12575	COG3381	protein complex oligomerization
HY59_RS12585	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HY59_RS12590	COG1940	carbohydrate kinase activity
HY59_RS12595	COG0583	DNA-binding transcription factor activity
HY59_RS12600	COG2814	Major facilitator Superfamily
HY59_RS12605	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HY59_RS12620	COG0583	DNA-binding transcription factor activity
HY59_RS12625	COG3591	Belongs to the peptidase S1B family
HY59_RS12630	COG3300	MHYT domain
HY59_RS12630	COG5001	Diguanylate cyclase
HY59_RS12640	COG2076	Multidrug Resistance protein
HY59_RS12645	COG0628	permease
HY59_RS12675	COG0679	Auxin Efflux Carrier
HY59_RS12685	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HY59_RS12695	COG2814	Major facilitator Superfamily
HY59_RS12710	COG3290	protein histidine kinase activity
HY59_RS12715	COG4565	transcriptional regulatory protein
HY59_RS12735	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HY59_RS12735	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HY59_RS12740	COG2814	Major facilitator Superfamily
HY59_RS12745	COG1566	PFAM secretion protein HlyD family protein
HY59_RS12750	COG1846	Transcriptional regulator
HY59_RS12760	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HY59_RS12760	COG3264	Mechanosensitive ion channel
HY59_RS12765	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HY59_RS12770	COG0596	Alpha beta hydrolase
HY59_RS12780	COG0183	Belongs to the thiolase family
HY59_RS12785	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HY59_RS12795	COG1414	Transcriptional regulator
HY59_RS12800	COG2840	Smr protein MutS2
HY59_RS12805	COG0583	DNA-binding transcription factor activity
HY59_RS12815	COG1473	amidohydrolase
HY59_RS12820	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HY59_RS12830	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HY59_RS12835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HY59_RS12840	COG0589	response to stress
HY59_RS12850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HY59_RS12855	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HY59_RS12865	COG0531	amino acid
HY59_RS12875	COG3136	membrane protein required for alginate biosynthesis
HY59_RS12880	COG0745	RESPONSE REGULATOR receiver
HY59_RS12885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HY59_RS12895	COG0583	DNA-binding transcription factor activity
HY59_RS12900	COG2205	protein histidine kinase activity
HY59_RS12915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HY59_RS12915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HY59_RS12920	COG1482	cell wall glycoprotein biosynthetic process
HY59_RS12925	COG5339	Protein conserved in bacteria
HY59_RS12930	COG1609	Transcriptional regulator
HY59_RS12935	COG1263	PTS System
HY59_RS12935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS12940	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HY59_RS12950	COG0306	phosphate transporter
HY59_RS12960	COG2391	methyltransferase activity
HY59_RS12965	COG0425	Belongs to the sulfur carrier protein TusA family
HY59_RS12975	COG2199	diguanylate cyclase activity
HY59_RS12990	COG0673	inositol 2-dehydrogenase activity
HY59_RS12995	COG2723	6-phospho-beta-galactosidase activity
HY59_RS13030	COG4659	FMN binding
HY59_RS13040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HY59_RS13050	COG0625	glutathione transferase activity
HY59_RS13055	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HY59_RS13070	COG3895	Periplasmic Protein
HY59_RS13095	COG1566	PFAM secretion protein HlyD family protein
HY59_RS13100	COG1289	transmembrane transporter activity
HY59_RS13105	COG2032	superoxide dismutase activity
HY59_RS13110	COG4989	oxidoreductase activity
HY59_RS13115	COG3313	Fe-S protein
HY59_RS13120	COG1309	transcriptional regulator
HY59_RS13125	COG1902	pentaerythritol trinitrate reductase activity
HY59_RS13130	COG0346	lactoylglutathione lyase activity
HY59_RS13140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HY59_RS13145	COG0791	NLP P60 protein
HY59_RS13160	COG2814	Major facilitator Superfamily
HY59_RS13170	COG0583	DNA-binding transcription factor activity
HY59_RS13175	COG2814	Major facilitator Superfamily
HY59_RS13180	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HY59_RS13185	COG0307	riboflavin synthase, alpha
HY59_RS13190	COG0534	Mate efflux family protein
HY59_RS13195	COG0583	DNA-binding transcription factor activity
HY59_RS13225	COG0523	cobalamin synthesis protein
HY59_RS13235	COG0693	protein deglycase activity
HY59_RS13240	COG5642	Protein of unknown function (DUF2384)
HY59_RS13245	COG5654	RES domain protein
HY59_RS13260	COG0583	DNA-binding transcription factor activity
HY59_RS13275	COG4529	Protein conserved in bacteria
HY59_RS13280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HY59_RS13290	COG2223	nitrite transmembrane transporter activity
HY59_RS13295	COG3829	transcription factor binding
HY59_RS13300	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HY59_RS13305	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HY59_RS13310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HY59_RS13320	COG0549	Belongs to the carbamate kinase family
HY59_RS13325	COG3608	succinylglutamate desuccinylase aspartoacylase
HY59_RS13325	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HY59_RS13330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HY59_RS13335	COG2068	MobA-Related Protein
HY59_RS13340	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS13340	COG0493	'glutamate synthase
HY59_RS13345	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS13350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS13355	COG0493	'glutamate synthase
HY59_RS13355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS13360	COG2233	PERMEase
HY59_RS13365	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS13370	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS13385	COG1349	DNA-binding transcription factor activity
HY59_RS13390	COG0346	lactoylglutathione lyase activity
HY59_RS13400	COG1393	Belongs to the ArsC family
HY59_RS13405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HY59_RS13410	COG0640	Transcriptional regulator
HY59_RS13415	COG0431	NADPH-dependent FMN reductase
HY59_RS13430	COG2011	ABC-type metal ion transport system permease component
HY59_RS13445	COG0747	negative chemotaxis
HY59_RS13460	COG0444	Belongs to the ABC transporter superfamily
HY59_RS13465	COG4608	Belongs to the ABC transporter superfamily
HY59_RS13470	COG4993	Dehydrogenase
HY59_RS13480	COG0583	DNA-binding transcription factor activity
HY59_RS13485	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HY59_RS13490	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HY59_RS13500	COG1250	3-hydroxyacyl-CoA dehydrogenase
HY59_RS13505	COG2610	gluconate transmembrane transporter activity
HY59_RS13510	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS13515	COG1278	Cold shock
HY59_RS13520	COG1278	Cold shock
HY59_RS13550	COG4235	cytochrome complex assembly
HY59_RS13550	COG3088	subunit of a heme lyase
HY59_RS13560	COG1138	Cytochrome C-type biogenesis protein
HY59_RS13570	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HY59_RS13575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HY59_RS13580	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HY59_RS13605	COG3842	ATPase activity
HY59_RS13625	COG0583	DNA-binding transcription factor activity
HY59_RS13630	COG1126	abc transporter atp-binding protein
HY59_RS13635	COG5285	phytanoyl-CoA dioxygenase
HY59_RS13655	COG0577	efflux transmembrane transporter activity
HY59_RS13655	COG1136	(ABC) transporter
HY59_RS13660	COG0577	efflux transmembrane transporter activity
HY59_RS13660	COG1136	(ABC) transporter
HY59_RS13665	COG0577	efflux transmembrane transporter activity
HY59_RS13665	COG1136	(ABC) transporter
HY59_RS13680	COG0672	)-iron permease
HY59_RS13685	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
HY59_RS13700	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HY59_RS13705	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS13710	COG1473	amidohydrolase
HY59_RS13720	COG1126	abc transporter atp-binding protein
HY59_RS13725	COG0765	amino acid transport
HY59_RS13745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS13750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS13755	COG1120	ATPase activity
HY59_RS13760	COG4774	siderophore transport
HY59_RS13765	COG1116	anion transmembrane transporter activity
HY59_RS13770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS13790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS13815	COG2814	Major facilitator Superfamily
HY59_RS13850	COG1414	Transcriptional regulator
HY59_RS13855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HY59_RS13860	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS13865	COG1120	ATPase activity
HY59_RS13875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HY59_RS13880	COG2271	Major facilitator Superfamily
HY59_RS13885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HY59_RS13885	COG1082	Xylose isomerase domain protein TIM barrel
HY59_RS13900	COG0469	pyruvate kinase activity
HY59_RS13910	COG1376	ErfK ybiS ycfS ynhG family protein
HY59_RS13925	COG0719	Fe-S assembly protein
HY59_RS13930	COG0396	ATPase activity
HY59_RS13935	COG0719	Fe-S assembly protein
HY59_RS13940	COG0316	Belongs to the HesB IscA family
HY59_RS13950	COG2261	transglycosylase associated protein
HY59_RS13955	COG3422	double-strand break repair
HY59_RS13960	COG2050	protein possibly involved in aromatic compounds catabolism
HY59_RS13965	COG0247	lactate metabolic process
HY59_RS13965	COG0277	FAD linked oxidase domain protein
HY59_RS13970	COG0628	permease
HY59_RS13980	COG0574	Belongs to the PEP-utilizing enzyme family
HY59_RS13980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HY59_RS13990	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HY59_RS13995	COG4256	Hemin uptake protein
HY59_RS14005	COG0791	NLP P60 protein
HY59_RS14015	COG0386	Belongs to the glutathione peroxidase family
HY59_RS14035	COG0583	DNA-binding transcription factor activity
HY59_RS14055	COG0072	phenylalanine-tRNA ligase activity
HY59_RS14055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HY59_RS14065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HY59_RS14090	COG3137	Salt-induced outer membrane protein
HY59_RS14095	COG1105	Belongs to the carbohydrate kinase PfkB family
HY59_RS14105	COG3001	Fructosamine kinase
HY59_RS14115	COG2350	Protein conserved in bacteria
HY59_RS14130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HY59_RS14140	COG0444	Belongs to the ABC transporter superfamily
HY59_RS14145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS14150	COG0601	transmembrane transport
HY59_RS14160	COG2095	MarC family integral membrane protein
HY59_RS14165	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS14165	COG1454	alcohol dehydrogenase
HY59_RS14180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HY59_RS14185	COG0745	RESPONSE REGULATOR receiver
HY59_RS14190	COG1752	Esterase of the alpha-beta hydrolase superfamily
HY59_RS14200	COG0788	formyltetrahydrofolate deformylase activity
HY59_RS14225	COG1522	sequence-specific DNA binding
HY59_RS14235	COG2181	nitrate reductase activity
HY59_RS14240	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HY59_RS14245	COG1140	nitrate reductase beta subunit
HY59_RS14250	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HY59_RS14255	COG2223	nitrite transmembrane transporter activity
HY59_RS14260	COG3850	Histidine kinase
HY59_RS14265	COG2197	response regulator
HY59_RS14270	COG4932	domain protein
HY59_RS14275	COG0243	molybdopterin cofactor binding
HY59_RS14280	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HY59_RS14280	COG2146	nitrite reductase [NAD(P)H] activity
HY59_RS14285	COG1116	anion transmembrane transporter activity
HY59_RS14295	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HY59_RS14300	COG3707	response regulator
HY59_RS14305	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HY59_RS14315	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HY59_RS14320	COG4572	Cation transport regulator
HY59_RS14325	COG0387	Pfam Sodium calcium exchanger
HY59_RS14345	COG2890	protein-(glutamine-N5) methyltransferase activity
HY59_RS14375	COG0659	secondary active sulfate transmembrane transporter activity
HY59_RS14395	COG0012	GTP binding
HY59_RS14405	COG0300	oxidoreductase activity
HY59_RS14415	COG0251	oxidation-reduction process
HY59_RS14430	COG4869	propanediol catabolic process
HY59_RS14445	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HY59_RS14455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HY59_RS14470	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS14480	COG0693	protein deglycase activity
HY59_RS14485	COG1882	Formate acetyltransferase
HY59_RS14490	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HY59_RS14505	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HY59_RS14515	COG2972	Histidine kinase
HY59_RS14545	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS14550	COG0251	oxidation-reduction process
HY59_RS14570	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HY59_RS14575	COG0277	FAD linked oxidase domain protein
HY59_RS14585	COG4977	sequence-specific DNA binding
HY59_RS14595	COG0564	pseudouridine synthase activity
HY59_RS14605	COG1760	l-serine dehydratase
HY59_RS14610	COG0251	oxidation-reduction process
HY59_RS14615	COG1882	Formate acetyltransferase
HY59_RS14635	COG0583	DNA-binding transcription factor activity
HY59_RS14650	COG1174	glycine betaine transport
HY59_RS14660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS14680	COG1940	carbohydrate kinase activity
HY59_RS14685	COG1653	transport
HY59_RS14700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS14705	COG3842	ATPase activity
HY59_RS14710	COG2814	Major facilitator Superfamily
HY59_RS14735	COG2308	Evidence 4 Homologs of previously reported genes of
HY59_RS14750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HY59_RS14755	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS14760	COG1120	ATPase activity
HY59_RS14765	COG0500	methyltransferase
HY59_RS14770	COG0157	Belongs to the NadC ModD family
HY59_RS14780	COG2258	MOSC domain
HY59_RS14785	COG4774	siderophore transport
HY59_RS14795	COG1619	proteins homologs of microcin C7 resistance protein MccF
HY59_RS14810	COG0589	response to stress
HY59_RS14820	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HY59_RS14855	COG2719	SpoVR family
HY59_RS14885	COG0179	Fumarylacetoacetate (FAA) hydrolase
HY59_RS14900	COG2894	cell division
HY59_RS14910	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HY59_RS14920	COG3065	identical protein binding
HY59_RS14925	COG1214	PFAM Peptidase M22, glycoprotease
HY59_RS14930	COG1199	ATP-dependent helicase activity
HY59_RS14935	COG0251	oxidation-reduction process
HY59_RS14955	COG1760	l-serine dehydratase
HY59_RS14960	COG2200	EAL domain
HY59_RS14965	COG1253	flavin adenine dinucleotide binding
HY59_RS14970	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS14970	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS14975	COG3715	PTS system
HY59_RS14980	COG3716	PTS system mannose fructose sorbose family IID component
HY59_RS14995	COG2226	methyltransferase
HY59_RS15000	COG0768	penicillin binding
HY59_RS15025	COG1414	Transcriptional regulator
HY59_RS15030	COG2814	Major facilitator Superfamily
HY59_RS15050	COG1956	GAF domain-containing protein
HY59_RS15055	COG2995	paraquat-inducible protein a
HY59_RS15060	COG3008	intermembrane lipid transfer
HY59_RS15085	COG2990	Protein conserved in bacteria
HY59_RS15100	COG1276	copper resistance
HY59_RS15105	COG2372	response to copper ion
HY59_RS15115	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HY59_RS15120	COG1770	oligopeptidase
HY59_RS15125	COG2979	Protein of unknown function (DUF533)
HY59_RS15130	COG3141	response to X-ray
HY59_RS15140	COG0800	Aldolase
HY59_RS15145	COG0129	dihydroxy-acid dehydratase activity
HY59_RS15150	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HY59_RS15155	COG1737	Transcriptional regulator
HY59_RS15165	COG3493	citrate carrier protein
HY59_RS15175	COG0281	malic enzyme
HY59_RS15180	COG4565	transcriptional regulatory protein
HY59_RS15185	COG1560	Kdo2-lipid A biosynthetic process
HY59_RS15190	COG0739	heme binding
HY59_RS15195	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HY59_RS15205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HY59_RS15230	COG0494	nUDIX hydrolase
HY59_RS15240	COG1335	isochorismatase
HY59_RS15245	COG1801	Protein of unknown function DUF72
HY59_RS15250	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HY59_RS15270	COG3102	Protein conserved in bacteria
HY59_RS15280	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HY59_RS15305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS15315	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS15320	COG1528	Iron-storage protein
HY59_RS15345	COG1528	Iron-storage protein
HY59_RS15355	COG0814	amino acid
HY59_RS15360	COG3318	Belongs to the UPF0149 family
HY59_RS15360	COG3012	SEC-C Motif Domain Protein
HY59_RS15365	COG3152	Membrane
HY59_RS15370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HY59_RS15400	COG2197	response regulator
HY59_RS15410	COG2197	response regulator
HY59_RS15415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HY59_RS15420	COG1126	abc transporter atp-binding protein
HY59_RS15425	COG0765	amino acid transport
HY59_RS15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS15440	COG0366	Alpha amylase catalytic
HY59_RS15470	COG5475	Uncharacterized small protein (DUF2158)
HY59_RS15475	COG2354	Protein conserved in bacteria
HY59_RS15480	COG0697	spore germination
HY59_RS15485	COG3727	T/G mismatch-specific endonuclease activity
HY59_RS15490	COG0270	DNA (cytosine-5-)-methyltransferase activity
HY59_RS15495	COG1418	mRNA catabolic process
HY59_RS15505	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HY59_RS15530	COG1737	Transcriptional regulator
HY59_RS15535	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS15540	COG1129	ABC transporter
HY59_RS15545	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS15555	COG1376	ErfK ybiS ycfS ynhG family protein
HY59_RS15575	COG1169	isochorismate synthase
HY59_RS15580	COG2814	Major facilitator Superfamily
HY59_RS15585	COG1132	(ABC) transporter
HY59_RS15590	COG2375	cellular response to nickel ion
HY59_RS15590	COG1132	(ABC) transporter
HY59_RS15600	COG2226	methyltransferase
HY59_RS15600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HY59_RS15600	COG3433	isochorismatase activity
HY59_RS15620	COG1021	2,3-dihydroxybenzoate-AMP ligase
HY59_RS15625	COG4771	TonB-dependent receptor
HY59_RS15630	COG1349	DNA-binding transcription factor activity
HY59_RS15665	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HY59_RS15680	COG0534	Mate efflux family protein
HY59_RS15690	COG2819	hydrolase of the alpha beta superfamily
HY59_RS15695	COG1414	Transcriptional regulator
HY59_RS15705	COG2814	Major facilitator Superfamily
HY59_RS15715	COG0656	L-ascorbic acid biosynthetic process
HY59_RS15720	COG1929	Belongs to the glycerate kinase type-1 family
HY59_RS15725	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS15730	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS15735	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS15740	COG1129	ABC transporter
HY59_RS15745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS15750	COG1063	alcohol dehydrogenase
HY59_RS15760	COG4670	ketone body catabolic process
HY59_RS15765	COG1309	transcriptional regulator
HY59_RS15770	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS15795	COG1960	acyl-CoA dehydrogenase activity
HY59_RS15815	COG3615	Tellurite resistance protein tehB
HY59_RS15820	COG5001	Diguanylate cyclase
HY59_RS15820	COG3300	MHYT domain
HY59_RS15830	COG0477	Major facilitator Superfamily
HY59_RS15835	COG0095	Lipoate-protein ligase
HY59_RS15840	COG0583	DNA-binding transcription factor activity
HY59_RS15845	COG1942	4-Oxalocrotonate Tautomerase
HY59_RS15855	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HY59_RS15870	COG1289	transmembrane transporter activity
HY59_RS15875	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HY59_RS15885	COG2925	Exonuclease
HY59_RS15890	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HY59_RS15895	COG0640	Transcriptional regulator
HY59_RS15900	COG0531	amino acid
HY59_RS15905	COG0583	DNA-binding transcription factor activity
HY59_RS15910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HY59_RS15935	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HY59_RS15945	COG0107	imidazoleglycerol-phosphate synthase activity
HY59_RS15960	COG1216	Glycosyl transferase, family 2
HY59_RS16015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HY59_RS16040	COG0297	glycogen (starch) synthase activity
HY59_RS16045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HY59_RS16050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HY59_RS16060	COG0297	glycogen (starch) synthase activity
HY59_RS16110	COG1253	flavin adenine dinucleotide binding
HY59_RS16115	COG2982	Protein involved in outer membrane biogenesis
HY59_RS16130	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HY59_RS16135	COG0443	Heat shock 70 kDa protein
HY59_RS16140	COG2205	protein histidine kinase activity
HY59_RS16155	COG1301	dicarboxylic acid transport
HY59_RS16165	COG1522	sequence-specific DNA binding
HY59_RS16180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS16190	COG5001	Diguanylate cyclase
HY59_RS16190	COG3300	MHYT domain
HY59_RS16215	COG2205	protein histidine kinase activity
HY59_RS16220	COG0745	RESPONSE REGULATOR receiver
HY59_RS16225	COG0826	peptidase U32
HY59_RS16235	COG2963	transposase activity
HY59_RS16245	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HY59_RS16255	COG1070	Carbohydrate kinase
HY59_RS16290	COG1830	Aldolase
HY59_RS16295	COG2211	Major facilitator Superfamily
HY59_RS16300	COG1397	ADP-ribosylglycohydrolase
HY59_RS16305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS16310	COG2188	Transcriptional regulator
HY59_RS16315	COG0351	phosphomethylpyrimidine kinase
HY59_RS16325	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HY59_RS16335	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HY59_RS16345	COG0583	DNA-binding transcription factor activity
HY59_RS16355	COG2252	PERMEase
HY59_RS16360	COG0583	DNA-binding transcription factor activity
HY59_RS16365	COG5455	response to cobalt ion
HY59_RS16370	COG0489	protein tyrosine kinase activity
HY59_RS16385	COG4807	Protein conserved in bacteria
HY59_RS16395	COG3275	phosphorelay sensor kinase activity
HY59_RS16400	COG0789	Transcriptional regulator
HY59_RS16405	COG1174	glycine betaine transport
HY59_RS16410	COG1125	glycine betaine transport
HY59_RS16415	COG1174	glycine betaine transport
HY59_RS16420	COG1732	Glycine betaine
HY59_RS16425	COG1472	Belongs to the glycosyl hydrolase 3 family
HY59_RS16430	COG0277	FAD linked oxidase domain protein
HY59_RS16440	COG1686	Belongs to the peptidase S11 family
HY59_RS16450	COG0586	Pfam SNARE associated Golgi protein
HY59_RS16455	COG1538	Outer membrane efflux protein
HY59_RS16460	COG2226	methyltransferase
HY59_RS16465	COG2723	6-phospho-beta-galactosidase activity
HY59_RS16480	COG3659	wide pore channel activity
HY59_RS16485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HY59_RS16495	COG1346	cytolysis
HY59_RS16505	COG2949	membrane
HY59_RS16515	COG1129	ABC transporter
HY59_RS16525	COG1609	Transcriptional regulator
HY59_RS16530	COG2311	Membrane
HY59_RS16545	COG2200	EAL domain
HY59_RS16550	COG4771	TonB-dependent receptor
HY59_RS16560	COG0833	amino acid
HY59_RS16565	COG0583	DNA-binding transcription factor activity
HY59_RS16570	COG2855	membrane
HY59_RS16580	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HY59_RS16580	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HY59_RS16580	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HY59_RS16585	COG1105	Belongs to the carbohydrate kinase PfkB family
HY59_RS16590	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS16590	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS16595	COG2814	Major facilitator Superfamily
HY59_RS16610	COG1312	Catalyzes the dehydration of D-mannonate
HY59_RS16615	COG0246	Mannitol dehydrogenase
HY59_RS16620	COG0523	cobalamin synthesis protein
HY59_RS16625	COG0671	phosphoesterase, PA-phosphatase related
HY59_RS16630	COG0791	NLP P60 protein
HY59_RS16635	COG2200	EAL domain
HY59_RS16640	COG4166	transmembrane transport
HY59_RS16645	COG4174	ABC transporter (Permease)
HY59_RS16650	COG4239	(ABC) transporter, permease
HY59_RS16655	COG4172	Belongs to the ABC transporter superfamily
HY59_RS16665	COG2814	Major facilitator Superfamily
HY59_RS16670	COG1187	pseudouridine synthase activity
HY59_RS16675	COG1061	Type III restriction enzyme res subunit
HY59_RS16695	COG0494	nUDIX hydrolase
HY59_RS16700	COG1349	DNA-binding transcription factor activity
HY59_RS16725	COG0628	permease
HY59_RS16740	COG0659	secondary active sulfate transmembrane transporter activity
HY59_RS16745	COG2239	Acts as a magnesium transporter
HY59_RS16750	COG4615	Cyclic peptide transporter
HY59_RS16760	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HY59_RS16760	COG2169	Transcriptional regulator
HY59_RS16775	COG0642	Histidine kinase
HY59_RS16775	COG2198	Histidine kinase
HY59_RS16800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HY59_RS16810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HY59_RS16815	COG0584	glycerophosphoryl diester phosphodiesterase
HY59_RS16820	COG2271	Major facilitator Superfamily
HY59_RS16825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HY59_RS16835	COG0247	lactate metabolic process
HY59_RS16845	COG2271	Major facilitator Superfamily
HY59_RS16855	COG1414	Transcriptional regulator
HY59_RS16900	COG1169	isochorismate synthase
HY59_RS16905	COG2153	protein acetylation
HY59_RS16920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HY59_RS16925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HY59_RS16935	COG0839	Belongs to the complex I subunit 6 family
HY59_RS16980	COG0583	DNA-binding transcription factor activity
HY59_RS16985	COG0436	Aminotransferase
HY59_RS16995	COG0490	domain, Protein
HY59_RS16995	COG0471	metal ion transport
HY59_RS17000	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HY59_RS17025	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HY59_RS17030	COG0622	Phosphoesterase
HY59_RS17035	COG0625	glutathione transferase activity
HY59_RS17045	COG0583	DNA-binding transcription factor activity
HY59_RS17050	COG0625	glutathione transferase activity
HY59_RS17055	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HY59_RS17060	COG1090	epimerase
HY59_RS17075	COG4598	ABC transporter
HY59_RS17080	COG4160	amino acid transport
HY59_RS17095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS17100	COG0163	prenyltransferase activity
HY59_RS17105	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HY59_RS17110	COG1286	toxin biosynthetic process
HY59_RS17115	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HY59_RS17120	COG0285	dihydrofolate synthase activity
HY59_RS17130	COG0586	Pfam SNARE associated Golgi protein
HY59_RS17140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HY59_RS17160	COG1447	Phosphotransferase system cellobiose-specific component IIA
HY59_RS17165	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS17175	COG2188	Transcriptional regulator
HY59_RS17185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HY59_RS17200	COG3101	peptidyl-lysine hydroxylation
HY59_RS17205	COG0730	response to heat
HY59_RS17230	COG2062	phosphohistidine phosphatase, SixA
HY59_RS17245	COG3691	Protein conserved in bacteria
HY59_RS17255	COG2853	Lipoprotein
HY59_RS17260	COG2116	formate transmembrane transporter activity
HY59_RS17290	COG0583	DNA-binding transcription factor activity
HY59_RS17295	COG0590	tRNA wobble adenosine to inosine editing
HY59_RS17300	COG2807	transmembrane transport
HY59_RS17305	COG0436	Aminotransferase
HY59_RS17310	COG3275	phosphorelay sensor kinase activity
HY59_RS17315	COG3279	Response regulator of the LytR AlgR family
HY59_RS17330	COG3961	Belongs to the TPP enzyme family
HY59_RS17335	COG0667	Aldo Keto reductase
HY59_RS17350	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HY59_RS17355	COG2200	EAL domain
HY59_RS17355	COG2199	diguanylate cyclase activity
HY59_RS17370	COG3415	Transposase
HY59_RS17375	COG3415	Transposase
HY59_RS17410	COG0583	DNA-binding transcription factor activity
HY59_RS17415	COG0385	Bile acid
HY59_RS17420	COG3530	Putative quorum-sensing-regulated virulence factor
HY59_RS17440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HY59_RS17445	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS17480	COG4319	ketosteroid isomerase
HY59_RS17490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HY59_RS17495	COG4208	sulfate ABC transporter
HY59_RS17500	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HY59_RS17505	COG4150	thiosulfate binding
HY59_RS17510	COG2837	iron assimilation
HY59_RS17530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HY59_RS17545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HY59_RS17550	COG5342	invasion associated locus B
HY59_RS17560	COG0493	'glutamate synthase
HY59_RS17560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS17565	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HY59_RS17570	COG1393	Belongs to the ArsC family
HY59_RS17605	COG0400	carboxylic ester hydrolase activity
HY59_RS17615	COG2321	neutral zinc metallopeptidase
HY59_RS17625	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HY59_RS17635	COG2716	regulation of RNA biosynthetic process
HY59_RS17640	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HY59_RS17645	COG0628	permease
HY59_RS17650	COG4783	chaperone-mediated protein folding
HY59_RS17655	COG1393	Belongs to the ArsC family
HY59_RS17665	COG2233	PERMEase
HY59_RS17675	COG2723	6-phospho-beta-galactosidase activity
HY59_RS17695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HY59_RS17700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HY59_RS17710	COG2200	EAL domain
HY59_RS17720	COG0583	DNA-binding transcription factor activity
HY59_RS17735	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HY59_RS17745	COG0517	IMP dehydrogenase activity
HY59_RS17745	COG0516	GMP reductase activity
HY59_RS17750	COG1570	exodeoxyribonuclease VII activity
HY59_RS17755	COG1645	bacterial-type flagellum-dependent swarming motility
HY59_RS17775	COG2976	Protein conserved in bacteria
HY59_RS17805	COG4953	penicillin-binding protein 1C
HY59_RS17810	COG2373	Large extracellular alpha-helical protein
HY59_RS17820	COG1473	amidohydrolase
HY59_RS17825	COG2897	thiosulfate sulfurtransferase activity
HY59_RS17840	COG2975	iron-sulfur cluster assembly
HY59_RS17845	COG0633	Ferredoxin
HY59_RS17865	COG0822	iron-sulfur transferase activity
HY59_RS17890	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HY59_RS17895	COG3683	transport system, periplasmic component
HY59_RS17900	COG3711	transcriptional antiterminator
HY59_RS17905	COG2814	Major facilitator Superfamily
HY59_RS17910	COG2017	converts alpha-aldose to the beta-anomer
HY59_RS17915	COG1063	alcohol dehydrogenase
HY59_RS17920	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS17925	COG1129	ABC transporter
HY59_RS17930	COG1879	ABC-type sugar transport system periplasmic component
HY59_RS17935	COG0457	Tetratricopeptide repeat
HY59_RS17940	COG1940	carbohydrate kinase activity
HY59_RS17945	COG2259	Doxx family
HY59_RS17960	COG0347	Belongs to the P(II) protein family
HY59_RS17965	COG2204	response regulator
HY59_RS17970	COG3170	Tfp pilus assembly protein FimV
HY59_RS17975	COG2205	protein histidine kinase activity
HY59_RS17980	COG0047	phosphoribosylformylglycinamidine synthase activity
HY59_RS17980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HY59_RS17995	COG0560	Phosphoserine phosphatase
HY59_RS18000	COG1737	Transcriptional regulator
HY59_RS18005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS18015	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HY59_RS18035	COG0681	Belongs to the peptidase S26 family
HY59_RS18045	COG3086	response to oxidative stress
HY59_RS18055	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HY59_RS18065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HY59_RS18075	COG0513	Belongs to the DEAD box helicase family
HY59_RS18090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HY59_RS18095	COG3118	belongs to the thioredoxin family
HY59_RS18100	COG3148	PFAM DTW domain containing protein
HY59_RS18110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HY59_RS18115	COG5544	Lipoprotein
HY59_RS18120	COG0477	Major facilitator Superfamily
HY59_RS18135	COG0542	response to heat
HY59_RS18150	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HY59_RS18155	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HY59_RS18160	COG0077	Prephenate dehydratase
HY59_RS18160	COG1605	Chorismate mutase
HY59_RS18170	COG1605	Chorismate mutase
HY59_RS18170	COG0287	Prephenate dehydrogenase
HY59_RS18175	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HY59_RS18180	COG2199	diguanylate cyclase activity
HY59_RS18185	COG2885	chlorophyll binding
HY59_RS18220	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HY59_RS18225	COG4137	Cytochrome C assembly protein
HY59_RS18230	COG4536	flavin adenine dinucleotide binding
HY59_RS18245	COG0497	DNA recombination
HY59_RS18260	COG2867	negative regulation of translational initiation
HY59_RS18275	COG0582	viral genome integration into host DNA
HY59_RS18330	COG0582	viral genome integration into host DNA
HY59_RS18340	COG2963	transposase activity
HY59_RS18370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HY59_RS18380	COG2184	nucleotidyltransferase activity
HY59_RS18425	COG3708	Transcriptional regulator
HY59_RS18425	COG2207	Transcriptional regulator
HY59_RS18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HY59_RS18470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS18480	COG0235	Class ii aldolase
HY59_RS18490	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS18505	COG3775	system Galactitol-specific IIC component
HY59_RS18535	COG4774	siderophore transport
HY59_RS18540	COG4607	ABC-type enterochelin transport system periplasmic component
HY59_RS18565	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HY59_RS18570	COG0747	negative chemotaxis
HY59_RS18575	COG0601	transmembrane transport
HY59_RS18580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS18585	COG0444	Belongs to the ABC transporter superfamily
HY59_RS18590	COG4608	Belongs to the ABC transporter superfamily
HY59_RS18600	COG3188	usher protein
HY59_RS18605	COG3121	Chaperone
HY59_RS18620	COG3284	Transcriptional regulator
HY59_RS18625	COG0671	phosphoesterase, PA-phosphatase related
HY59_RS18630	COG0583	DNA-binding transcription factor activity
HY59_RS18640	COG0640	Transcriptional regulator
HY59_RS18645	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HY59_RS18670	COG4575	ribosome binding
HY59_RS18680	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HY59_RS18685	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HY59_RS18695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HY59_RS18700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HY59_RS18710	COG4176	ABC-type proline glycine betaine transport system permease component
HY59_RS18720	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HY59_RS18730	COG1846	Transcriptional regulator
HY59_RS18735	COG1566	PFAM secretion protein HlyD family protein
HY59_RS18740	COG2814	Major facilitator Superfamily
HY59_RS18745	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HY59_RS18765	COG1238	metal cluster binding
HY59_RS18770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HY59_RS18775	COG2823	Periplasmic or secreted lipoprotein
HY59_RS18805	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HY59_RS18825	COG1546	Belongs to the CinA family
HY59_RS18830	COG0803	Belongs to the bacterial solute-binding protein 9 family
HY59_RS18835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HY59_RS18845	COG2951	lytic endotransglycosylase activity
HY59_RS18850	COG3730	PTS system glucitol sorbitol-specific
HY59_RS18855	COG3732	PTS system glucitol sorbitol-specific
HY59_RS18865	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS18870	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS18875	COG1349	DNA-binding transcription factor activity
HY59_RS18900	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
HY59_RS18905	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HY59_RS18910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS18915	COG1609	Transcriptional regulator
HY59_RS18920	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS18920	COG1263	PTS System
HY59_RS18925	COG2723	6-phospho-beta-galactosidase activity
HY59_RS18930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HY59_RS18940	COG3260	NADH ubiquinone oxidoreductase 20
HY59_RS18945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HY59_RS18950	COG3261	NADH dehydrogenase
HY59_RS18950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HY59_RS18955	COG0650	Formate hydrogenlyase subunit 4
HY59_RS18960	COG0651	ATP synthesis coupled electron transport
HY59_RS18965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS18980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HY59_RS18985	COG0298	carbon dioxide binding
HY59_RS18990	COG0409	Hydrogenase expression formation protein
HY59_RS18995	COG0309	Hydrogenase expression formation protein (HypE)
HY59_RS19005	COG3585	molybdate ion transport
HY59_RS19005	COG2005	Transcriptional regulator
HY59_RS19015	COG1121	(ABC) transporter
HY59_RS19020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HY59_RS19025	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HY59_RS19045	COG3720	iron ion transport
HY59_RS19050	COG4558	Periplasmic binding protein
HY59_RS19055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HY59_RS19060	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HY59_RS19085	COG0477	Major facilitator Superfamily
HY59_RS19095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HY59_RS19130	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HY59_RS19160	COG2234	aminopeptidase activity
HY59_RS19180	COG0720	synthase
HY59_RS19185	COG0602	queuosine metabolic process
HY59_RS19195	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HY59_RS19200	COG2190	(PTS) system
HY59_RS19200	COG1263	PTS System
HY59_RS19200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS19205	COG1737	Transcriptional regulator
HY59_RS19210	COG0148	phosphopyruvate hydratase activity
HY59_RS19220	COG3956	TIGRFAM MazG family protein
HY59_RS19225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HY59_RS19235	COG2205	protein histidine kinase activity
HY59_RS19235	COG4999	Histidine kinase
HY59_RS19235	COG3850	Histidine kinase
HY59_RS19235	COG3437	response regulator, receiver
HY59_RS19240	COG1929	Belongs to the glycerate kinase type-1 family
HY59_RS19245	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS19250	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS19255	COG2271	Major facilitator Superfamily
HY59_RS19260	COG0716	FMN binding
HY59_RS19265	COG0564	pseudouridine synthase activity
HY59_RS19270	COG3098	single-species biofilm formation
HY59_RS19285	COG1611	Belongs to the LOG family
HY59_RS19290	COG0814	amino acid
HY59_RS19295	COG1760	l-serine dehydratase
HY59_RS19300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HY59_RS19310	COG0477	Major facilitator Superfamily
HY59_RS19315	COG1464	Belongs to the NlpA lipoprotein family
HY59_RS19320	COG2011	ABC-type metal ion transport system permease component
HY59_RS19325	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HY59_RS19340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS19345	COG3829	transcription factor binding
HY59_RS19355	COG1454	alcohol dehydrogenase
HY59_RS19360	COG0235	Class ii aldolase
HY59_RS19365	COG0738	Major facilitator superfamily
HY59_RS19385	COG1349	DNA-binding transcription factor activity
HY59_RS19395	COG2363	Small membrane protein
HY59_RS19400	COG0583	DNA-binding transcription factor activity
HY59_RS19405	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HY59_RS19410	COG2166	iron-sulfur cluster assembly
HY59_RS19415	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HY59_RS19420	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HY59_RS19465	COG0860	N-Acetylmuramoyl-L-alanine amidase
HY59_RS19470	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HY59_RS19470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HY59_RS19475	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HY59_RS19480	COG1074	ATP-dependent DNA helicase activity
HY59_RS19485	COG1025	Belongs to the peptidase M16 family
HY59_RS19490	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HY59_RS19495	COG4967	type IV pilus modification protein PilV
HY59_RS19505	COG4795	General secretion pathway protein
HY59_RS19510	COG2165	general secretion pathway protein
HY59_RS19540	COG0861	Integral membrane protein TerC family
HY59_RS19550	COG0667	Aldo Keto reductase
HY59_RS19565	COG1609	Transcriptional regulator
HY59_RS19575	COG1609	Transcriptional regulator
HY59_RS19585	COG0583	DNA-binding transcription factor activity
HY59_RS19590	COG1794	racemase activity, acting on amino acids and derivatives
HY59_RS19595	COG1917	Cupin 2, conserved barrel domain protein
HY59_RS19600	COG1175	transmembrane transport
HY59_RS19605	COG0395	ABC-type sugar transport system, permease component
HY59_RS19610	COG3842	ATPase activity
HY59_RS19620	COG0823	Involved in the tonB-independent uptake of proteins
HY59_RS19645	COG2814	Major facilitator Superfamily
HY59_RS19650	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS19655	COG0823	Involved in the tonB-independent uptake of proteins
HY59_RS19665	COG0183	Belongs to the thiolase family
HY59_RS19680	COG0814	amino acid
HY59_RS19685	COG0667	Aldo Keto reductase
HY59_RS19700	COG2200	EAL domain
HY59_RS19700	COG2199	diguanylate cyclase activity
HY59_RS19750	COG0697	spore germination
HY59_RS19755	COG1846	Transcriptional regulator
HY59_RS19760	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HY59_RS19770	COG0154	amidase activity
HY59_RS19790	COG4638	Rieske (2fe-2S)
HY59_RS19800	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS19810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HY59_RS19840	COG0582	viral genome integration into host DNA
HY59_RS19845	COG4974	Belongs to the 'phage' integrase family
HY59_RS19855	COG3539	Fimbrial protein
HY59_RS19860	COG3121	Chaperone
HY59_RS19865	COG3188	usher protein
HY59_RS19870	COG3539	Fimbrial protein
HY59_RS19875	COG3539	Fimbrial protein
HY59_RS19880	COG3539	Fimbrial protein
HY59_RS19910	COG2388	GCN5-related N-acetyl-transferase
HY59_RS19915	COG3592	Divergent 4Fe-4S mono-cluster
HY59_RS19930	COG1289	transmembrane transporter activity
HY59_RS19935	COG1538	Outer membrane efflux protein
HY59_RS19970	COG4942	peptidase
HY59_RS19990	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HY59_RS20000	COG4974	Belongs to the 'phage' integrase family
HY59_RS20025	COG1272	protein, Hemolysin III
HY59_RS20035	COG1737	Transcriptional regulator
HY59_RS20040	COG2723	6-phospho-beta-galactosidase activity
HY59_RS20060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HY59_RS20065	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS20085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HY59_RS20090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HY59_RS20095	COG0006	proline dipeptidase activity
HY59_RS20115	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HY59_RS20120	COG3647	Membrane
HY59_RS20125	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HY59_RS20145	COG2968	Membrane
HY59_RS20150	COG1279	arginine transmembrane transporter activity
HY59_RS20155	COG0668	transmembrane transport
HY59_RS20160	COG0191	fructose-bisphosphate aldolase activity
HY59_RS20175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HY59_RS20180	COG0501	Belongs to the peptidase M48B family
HY59_RS20195	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
HY59_RS20200	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS20205	COG2267	carboxylic ester hydrolase activity
HY59_RS20215	COG2814	Major facilitator Superfamily
HY59_RS20230	COG1414	Transcriptional regulator
HY59_RS20235	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS20250	COG2146	nitrite reductase [NAD(P)H] activity
HY59_RS20280	COG2814	Major facilitator Superfamily
HY59_RS20290	COG2356	endonuclease I
HY59_RS20295	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HY59_RS20315	COG2197	response regulator
HY59_RS20320	COG2805	Type II/IV secretion system protein
HY59_RS20325	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HY59_RS20330	COG0762	integral membrane protein
HY59_RS20345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HY59_RS20360	COG4214	carbohydrate transport
HY59_RS20370	COG3171	Protein conserved in bacteria
HY59_RS20380	COG1194	a g-specific adenine glycosylase
HY59_RS20395	COG2211	Major facilitator Superfamily
HY59_RS20400	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
HY59_RS20420	COG3052	prosthetic group binding
HY59_RS20430	COG0179	Fumarylacetoacetate (FAA) hydrolase
HY59_RS20435	COG3493	citrate carrier protein
HY59_RS20450	COG1982	Orn Lys Arg decarboxylase major
HY59_RS20455	COG1811	Na channel or pump
HY59_RS20465	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HY59_RS20505	COG2994	toxin metabolic process
HY59_RS20545	COG2801	Transposase and inactivated derivatives
HY59_RS20560	COG3121	Chaperone
HY59_RS20585	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HY59_RS20590	COG2211	Major facilitator Superfamily
HY59_RS20600	COG2207	Transcriptional regulator
HY59_RS20600	COG1609	Transcriptional regulator
HY59_RS20605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HY59_RS20610	COG1126	abc transporter atp-binding protein
HY59_RS20615	COG0765	amino acid transport
HY59_RS20625	COG0626	cystathionine gamma-synthase activity
HY59_RS20630	COG0583	DNA-binding transcription factor activity
HY59_RS20640	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HY59_RS20660	COG2072	flavoprotein involved in K transport
HY59_RS20665	COG0583	DNA-binding transcription factor activity
HY59_RS20670	COG1012	belongs to the aldehyde dehydrogenase family
HY59_RS20690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HY59_RS20695	COG0754	glutathionylspermidine amidase activity
HY59_RS20705	COG0625	glutathione transferase activity
HY59_RS20720	COG0667	Aldo Keto reductase
HY59_RS20730	COG0848	biopolymer transport protein
HY59_RS20750	COG3842	ATPase activity
HY59_RS20755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HY59_RS20760	COG0725	ABC transporter, periplasmic molybdate-binding protein
HY59_RS20765	COG2207	Transcriptional regulator
HY59_RS20770	COG1979	alcohol dehydrogenase
HY59_RS20780	COG1032	radical SAM domain protein
HY59_RS20785	COG2132	Multicopper oxidase
HY59_RS20790	COG0204	Acyl-transferase
HY59_RS20795	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HY59_RS20800	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HY59_RS20805	COG3111	PFAM Bacterial OB fold (BOF) protein
HY59_RS20815	COG0642	Histidine kinase
HY59_RS20820	COG2249	NAD(P)H dehydrogenase (quinone) activity
HY59_RS20825	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HY59_RS20830	COG0187	DNA topoisomerase II activity
HY59_RS20835	COG3150	esterase
HY59_RS20840	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HY59_RS20845	COG3151	Protein conserved in bacteria
HY59_RS20855	COG1538	Outer membrane efflux protein
HY59_RS20865	COG0754	glutathionylspermidine amidase activity
HY59_RS20870	COG3384	dioxygenase
HY59_RS20885	COG2960	long-chain fatty acid transporting porin activity
HY59_RS20905	COG3025	triphosphatase activity
HY59_RS20910	COG4991	sh3 domain protein
HY59_RS20925	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HY59_RS20935	COG0477	Major facilitator Superfamily
HY59_RS20985	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HY59_RS20990	COG0358	DNA primase activity
HY59_RS21025	COG2376	Dihydroxyacetone kinase
HY59_RS21030	COG1461	Dihydroxyacetone kinase
HY59_RS21045	COG2375	cellular response to nickel ion
HY59_RS21060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HY59_RS21065	COG1609	Transcriptional regulator
HY59_RS21070	COG3250	beta-galactosidase activity
HY59_RS21075	COG2731	YhcH YjgK YiaL family protein
HY59_RS21080	COG0531	amino acid
HY59_RS21085	COG0531	amino acid
HY59_RS21095	COG3408	Glycogen debranching enzyme
HY59_RS21095	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HY59_RS21120	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS21140	COG0446	pyridine nucleotide-disulphide oxidoreductase
HY59_RS21140	COG1902	pentaerythritol trinitrate reductase activity
HY59_RS21150	COG1451	nucleotide metabolic process
HY59_RS21155	COG0673	inositol 2-dehydrogenase activity
HY59_RS21160	COG0861	Integral membrane protein TerC family
HY59_RS21170	COG2721	sulfolactate sulfo-lyase activity
HY59_RS21180	COG2271	Major facilitator Superfamily
HY59_RS21185	COG2186	Transcriptional regulator
HY59_RS21190	COG0586	Pfam SNARE associated Golgi protein
HY59_RS21200	COG1422	Protein of unknown function (DUF1090)
HY59_RS21205	COG4575	ribosome binding
HY59_RS21210	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HY59_RS21220	COG2259	Doxx family
HY59_RS21225	COG0435	Glutathione S-transferase
HY59_RS21230	COG3152	Membrane
HY59_RS21235	COG0583	DNA-binding transcription factor activity
HY59_RS21240	COG1741	Belongs to the pirin family
HY59_RS21250	COG1929	Belongs to the glycerate kinase type-1 family
HY59_RS21255	COG2084	Dehydrogenase
HY59_RS21265	COG2721	sulfolactate sulfo-lyase activity
HY59_RS21270	COG1349	DNA-binding transcription factor activity
HY59_RS21280	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS21290	COG3716	PTS system mannose fructose sorbose family IID component
HY59_RS21295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS21300	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HY59_RS21305	COG2222	sugar isomerase
HY59_RS21320	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HY59_RS21340	COG2823	Periplasmic or secreted lipoprotein
HY59_RS21345	COG0701	Predicted permease
HY59_RS21350	COG0702	epimerase
HY59_RS21365	COG3153	acetyltransferase
HY59_RS21370	COG3154	lipid carrier protein
HY59_RS21375	COG0826	peptidase U32
HY59_RS21380	COG0826	peptidase U32
HY59_RS21385	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HY59_RS21390	COG0814	amino acid
HY59_RS21395	COG0513	Belongs to the DEAD box helicase family
HY59_RS21425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HY59_RS21430	COG0195	Participates in both transcription termination and antitermination
HY59_RS21470	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HY59_RS21480	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HY59_RS21495	COG1534	Rna-binding protein
HY59_RS21505	COG2027	D-alanyl-D-alanine carboxypeptidase
HY59_RS21515	COG0697	spore germination
HY59_RS21530	COG0142	geranyltranstransferase activity
HY59_RS21535	COG3423	Transcriptional regulator
HY59_RS21545	COG5007	Belongs to the BolA IbaG family
HY59_RS21550	COG3113	response to antibiotic
HY59_RS21555	COG2854	intermembrane phospholipid transfer
HY59_RS21560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HY59_RS21565	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HY59_RS21570	COG1127	ABC transporter
HY59_RS21575	COG0530	calcium, potassium:sodium antiporter activity
HY59_RS21585	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HY59_RS21590	COG3117	lipopolysaccharide transmembrane transporter activity
HY59_RS21595	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HY59_RS21600	COG1137	ATPase activity
HY59_RS21605	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HY59_RS21610	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HY59_RS21615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS21625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS21630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HY59_RS21635	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HY59_RS21640	COG2198	Histidine kinase
HY59_RS21640	COG0784	Response regulator, receiver
HY59_RS21640	COG5002	protein histidine kinase activity
HY59_RS21645	COG1242	4 iron, 4 sulfur cluster binding
HY59_RS21650	COG0070	glutamate synthase
HY59_RS21650	COG0067	glutamate synthase
HY59_RS21650	COG0069	glutamate synthase activity
HY59_RS21655	COG0493	'glutamate synthase
HY59_RS21660	COG2731	YhcH YjgK YiaL family protein
HY59_RS21690	COG2969	positive regulation of protein catabolic process
HY59_RS21695	COG0625	glutathione transferase activity
HY59_RS21710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HY59_RS21715	COG3105	Protein conserved in bacteria
HY59_RS21720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HY59_RS21725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HY59_RS21730	COG1063	alcohol dehydrogenase
HY59_RS21735	COG2814	Major facilitator Superfamily
HY59_RS21750	COG1917	Cupin 2, conserved barrel domain protein
HY59_RS21750	COG4977	sequence-specific DNA binding
HY59_RS21775	COG2732	(Barnase) inhibitor
HY59_RS21780	COG1289	transmembrane transporter activity
HY59_RS21795	COG0583	DNA-binding transcription factor activity
HY59_RS21800	COG0312	modulator of DNA gyrase
HY59_RS21805	COG3164	Protein of unknown function
HY59_RS21810	COG1530	ribonuclease E activity
HY59_RS21820	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HY59_RS21825	COG1792	Involved in formation and maintenance of cell shape
HY59_RS21830	COG1077	Cell shape determining protein MreB Mrl
HY59_RS21835	COG2199	diguanylate cyclase activity
HY59_RS21835	COG2200	EAL domain
HY59_RS21840	COG0604	alcohol dehydrogenase
HY59_RS21855	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HY59_RS21860	COG0511	ligase activity, forming carbon-carbon bonds
HY59_RS21865	COG0439	Biotin carboxylase
HY59_RS21870	COG3924	membrane
HY59_RS21875	COG4145	pantothenate transmembrane transporter activity
HY59_RS21930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HY59_RS21940	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HY59_RS21950	COG0551	DNA topoisomerase type I activity
HY59_RS21960	COG0758	DNA mediated transformation
HY59_RS21990	COG3036	rescue of stalled ribosome
HY59_RS21995	COG0789	Transcriptional regulator
HY59_RS22010	COG0202	RNA polymerase activity
HY59_RS22020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HY59_RS22035	COG0201	protein transport
HY59_RS22050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HY59_RS22090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HY59_RS22100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HY59_RS22115	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HY59_RS22140	COG0051	transcription antitermination factor activity, RNA binding
HY59_RS22190	COG2964	Protein conserved in bacteria
HY59_RS22195	COG0545	Peptidyl-prolyl cis-trans isomerase
HY59_RS22205	COG1047	Peptidyl-prolyl cis-trans
HY59_RS22210	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HY59_RS22225	COG0488	(ABC) transporter
HY59_RS22235	COG0429	hydrolase of the alpha beta-hydrolase fold
HY59_RS22245	COG3954	Phosphoribulokinase
HY59_RS22250	COG1765	OsmC-like protein
HY59_RS22260	COG1289	transmembrane transporter activity
HY59_RS22275	COG2184	nucleotidyltransferase activity
HY59_RS22290	COG0738	Major facilitator superfamily
HY59_RS22295	COG0402	S-adenosylhomocysteine deaminase activity
HY59_RS22300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HY59_RS22325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HY59_RS22330	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HY59_RS22335	COG3266	domain, Protein
HY59_RS22350	COG4796	Type ii and iii secretion system protein
HY59_RS22365	COG3166	PFAM Fimbrial assembly family protein
HY59_RS22370	COG4972	Pilus assembly protein
HY59_RS22375	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HY59_RS22380	COG0494	nUDIX hydrolase
HY59_RS22390	COG1011	Hydrolase
HY59_RS22395	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HY59_RS22420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HY59_RS22425	COG2183	response to ionizing radiation
HY59_RS22430	COG1918	ferrous iron import across plasma membrane
HY59_RS22455	COG1040	competence protein
HY59_RS22465	COG2610	gluconate transmembrane transporter activity
HY59_RS22470	COG1640	4-alpha-glucanotransferase
HY59_RS22475	COG0058	SHG alpha-glucan phosphorylase activity
HY59_RS22485	COG1349	DNA-binding transcription factor activity
HY59_RS22495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HY59_RS22500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HY59_RS22505	COG0058	SHG alpha-glucan phosphorylase activity
HY59_RS22530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HY59_RS22535	COG2610	gluconate transmembrane transporter activity
HY59_RS22540	COG3265	gluconokinase activity
HY59_RS22545	COG1609	Transcriptional regulator
HY59_RS22550	COG1741	Belongs to the pirin family
HY59_RS22555	COG0673	inositol 2-dehydrogenase activity
HY59_RS22560	COG1247	-acetyltransferase
HY59_RS22565	COG0405	Gamma-glutamyltransferase
HY59_RS22575	COG0584	glycerophosphoryl diester phosphodiesterase
HY59_RS22600	COG1414	Transcriptional regulator
HY59_RS22605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HY59_RS22610	COG2271	Major facilitator Superfamily
HY59_RS22615	COG2721	sulfolactate sulfo-lyase activity
HY59_RS22625	COG0411	ABC transporter
HY59_RS22640	COG0683	leucine binding
HY59_RS22645	COG0456	acetyltransferase
HY59_RS22650	COG0683	leucine binding
HY59_RS22660	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HY59_RS22675	COG2177	Part of the ABC transporter FtsEX involved in
HY59_RS22680	COG2884	Cell division ATP-binding protein ftsE
HY59_RS22685	COG0552	protein localization to endoplasmic reticulum
HY59_RS22690	COG0742	ribosomal rna small subunit methyltransferase
HY59_RS22695	COG3776	membrane
HY59_RS22705	COG3714	YhhN family
HY59_RS22720	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HY59_RS22730	COG0477	Major facilitator Superfamily
HY59_RS22755	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HY59_RS22765	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HY59_RS22765	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HY59_RS22800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HY59_RS22810	COG1028	Short-chain dehydrogenase reductase Sdr
HY59_RS22815	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HY59_RS22820	COG2091	lysine biosynthetic process via aminoadipic acid
HY59_RS22860	COG3479	Phenolic acid decarboxylase
HY59_RS22870	COG0747	negative chemotaxis
HY59_RS22875	COG0601	transmembrane transport
HY59_RS22880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS22900	COG2239	Acts as a magnesium transporter
HY59_RS22905	COG2081	HI0933 family
HY59_RS22910	COG0306	phosphate transporter
HY59_RS22930	COG0589	response to stress
HY59_RS22940	COG1959	2 iron, 2 sulfur cluster binding
HY59_RS22960	COG0671	phosphoesterase, PA-phosphatase related
HY59_RS22965	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HY59_RS22970	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HY59_RS22980	COG0625	glutathione transferase activity
HY59_RS22985	COG1454	alcohol dehydrogenase
HY59_RS22995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HY59_RS23005	COG0583	DNA-binding transcription factor activity
HY59_RS23010	COG1295	ribonuclease BN
HY59_RS23015	COG0477	Major facilitator Superfamily
HY59_RS23020	COG2982	Protein involved in outer membrane biogenesis
HY59_RS23030	COG0612	Peptidase, M16
HY59_RS23040	COG2200	EAL domain
HY59_RS23040	COG2199	diguanylate cyclase activity
HY59_RS23045	COG0457	Tetratricopeptide repeat
HY59_RS23045	COG3118	belongs to the thioredoxin family
HY59_RS23055	COG1215	transferase activity, transferring glycosyl groups
HY59_RS23085	COG2194	sulfuric ester hydrolase activity
HY59_RS23125	COG0489	protein tyrosine kinase activity
HY59_RS23135	COG4608	Belongs to the ABC transporter superfamily
HY59_RS23140	COG0444	Belongs to the ABC transporter superfamily
HY59_RS23145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HY59_RS23150	COG0601	transmembrane transport
HY59_RS23155	COG0747	negative chemotaxis
HY59_RS23175	COG2223	nitrite transmembrane transporter activity
HY59_RS23180	COG5571	outer membrane autotransporter
HY59_RS23185	COG2818	Glycosylase
HY59_RS23190	COG0456	acetyltransferase
HY59_RS23195	COG0243	molybdopterin cofactor binding
HY59_RS23200	COG2885	chlorophyll binding
HY59_RS23205	COG1609	Transcriptional regulator
HY59_RS23215	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS23235	COG2814	Major facilitator Superfamily
HY59_RS23240	COG2944	sequence-specific DNA binding
HY59_RS23245	COG1278	Cold shock
HY59_RS23280	COG3274	enterobacterial common antigen metabolic process
HY59_RS23285	COG1070	Carbohydrate kinase
HY59_RS23295	COG4213	ABC transporter substrate-binding protein
HY59_RS23305	COG4214	carbohydrate transport
HY59_RS23310	COG2207	Transcriptional regulator
HY59_RS23310	COG1609	Transcriptional regulator
HY59_RS23315	COG2992	FlgJ-related protein
HY59_RS23320	COG0366	Alpha amylase catalytic
HY59_RS23325	COG3977	Valine--pyruvate aminotransferase
HY59_RS23330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HY59_RS23335	COG1414	Transcriptional regulator
HY59_RS23340	COG1129	ABC transporter
HY59_RS23345	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS23365	COG2731	YhcH YjgK YiaL family protein
HY59_RS23375	COG2271	Major facilitator Superfamily
HY59_RS23380	COG1070	Carbohydrate kinase
HY59_RS23385	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HY59_RS23390	COG3623	hexulose-6-phosphate isomerase
HY59_RS23395	COG0235	Class ii aldolase
HY59_RS23405	COG2211	Major facilitator Superfamily
HY59_RS23415	COG3276	selenocysteine insertion sequence binding
HY59_RS23425	COG0625	glutathione transferase activity
HY59_RS23430	COG1566	PFAM secretion protein HlyD family protein
HY59_RS23440	COG2213	PTS system mannitol-specific
HY59_RS23440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HY59_RS23450	COG3722	fumarate hydratase activity
HY59_RS23470	COG2186	Transcriptional regulator
HY59_RS23480	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HY59_RS23500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HY59_RS23505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HY59_RS23515	COG4942	peptidase
HY59_RS23520	COG2861	carbohydrate metabolic process
HY59_RS23525	COG0463	Glycosyl transferase, family 2
HY59_RS23535	COG0156	8-amino-7-oxononanoate synthase activity
HY59_RS23545	COG0859	PFAM glycosyl transferase family 9
HY59_RS23550	COG0859	PFAM glycosyl transferase family 9
HY59_RS23575	COG0859	PFAM glycosyl transferase family 9
HY59_RS23585	COG0438	transferase activity, transferring glycosyl groups
HY59_RS23590	COG1216	Glycosyl transferase, family 2
HY59_RS23595	COG1519	Transferase
HY59_RS23615	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HY59_RS23620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HY59_RS23630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HY59_RS23645	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HY59_RS23655	COG1561	YicC-like family, N-terminal region
HY59_RS23660	COG2860	membrane
HY59_RS23680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HY59_RS23685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HY59_RS23690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HY59_RS23695	COG1494	fructose-1,6-bisphosphatase
HY59_RS23705	COG3152	Membrane
HY59_RS23730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HY59_RS23735	COG3074	FtsZ-dependent cytokinesis
HY59_RS23750	COG0786	glutamate:sodium symporter activity
HY59_RS23755	COG2233	PERMEase
HY59_RS23760	COG2982	Protein involved in outer membrane biogenesis
HY59_RS23765	COG1263	PTS System
HY59_RS23765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS23770	COG1486	melibiose metabolic process
HY59_RS23795	COG0604	alcohol dehydrogenase
HY59_RS23805	COG1064	alcohol dehydrogenase
HY59_RS23815	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HY59_RS23830	COG1464	Belongs to the NlpA lipoprotein family
HY59_RS23835	COG3708	Transcriptional regulator
HY59_RS23835	COG2207	Transcriptional regulator
HY59_RS23855	COG0583	DNA-binding transcription factor activity
HY59_RS23895	COG2814	Major facilitator Superfamily
HY59_RS23905	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HY59_RS23905	COG1263	PTS System
HY59_RS23915	COG0697	spore germination
HY59_RS23925	COG1609	Transcriptional regulator
HY59_RS23935	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS23935	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HY59_RS23940	COG1447	Phosphotransferase system cellobiose-specific component IIA
HY59_RS23945	COG4580	involved in the transport of maltose and maltodextrins
HY59_RS23970	COG2188	Transcriptional regulator
HY59_RS24005	COG0531	amino acid
HY59_RS24015	COG0531	amino acid
HY59_RS24020	COG0124	histidyl-tRNA synthetase
HY59_RS24025	COG0124	histidyl-tRNA synthetase
HY59_RS24045	COG2197	response regulator
HY59_RS24055	COG0738	Major facilitator superfamily
HY59_RS24065	COG1349	DNA-binding transcription factor activity
HY59_RS24070	COG0440	acetolactate synthase activity
HY59_RS24075	COG0028	Belongs to the TPP enzyme family
HY59_RS24095	COG2814	Major facilitator Superfamily
HY59_RS24100	COG0583	DNA-binding transcription factor activity
HY59_RS24105	COG2610	gluconate transmembrane transporter activity
HY59_RS24120	COG2149	membrane
HY59_RS24135	COG2188	Transcriptional regulator
HY59_RS24155	COG5645	(Lipo)protein
HY59_RS24160	COG0823	Involved in the tonB-independent uptake of proteins
HY59_RS24165	COG2271	Major facilitator Superfamily
HY59_RS24170	COG4948	Mandelate Racemase Muconate Lactonizing
HY59_RS24175	COG0800	Aldolase
HY59_RS24180	COG3734	2-keto-3-deoxy-galactonokinase
HY59_RS24185	COG2186	Transcriptional regulator
HY59_RS24195	COG0561	phosphatase activity
HY59_RS24200	COG0187	DNA topoisomerase II activity
HY59_RS24210	COG0592	DNA-directed DNA polymerase activity
HY59_RS24235	COG0454	-acetyltransferase
HY59_RS24250	COG2091	lysine biosynthetic process via aminoadipic acid
HY59_RS24255	COG0431	NADPH-dependent FMN reductase
HY59_RS24260	COG2252	PERMEase
HY59_RS24265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HY59_RS24270	COG0704	Plays a role in the regulation of phosphate uptake
HY59_RS24275	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HY59_RS24280	COG0581	inorganic phosphate transmembrane transporter activity
HY59_RS24285	COG0573	inorganic phosphate transmembrane transporter activity
HY59_RS24290	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HY59_RS24315	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HY59_RS24350	COG3312	ion transport
HY59_RS24365	COG0716	FMN binding
HY59_RS24370	COG1522	sequence-specific DNA binding
HY59_RS24400	COG1129	ABC transporter
HY59_RS24405	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS24415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HY59_RS24420	COG1609	Transcriptional regulator
HY59_RS24425	COG0477	Major facilitator Superfamily
HY59_RS24430	COG2186	Transcriptional regulator
HY59_RS24445	COG1763	Mo-molybdopterin cofactor biosynthetic process
HY59_RS24450	COG0746	molybdenum cofactor guanylyltransferase activity
HY59_RS24455	COG3084	Protein conserved in bacteria
HY59_RS24460	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HY59_RS24470	COG0204	Acyl-transferase
HY59_RS24475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HY59_RS24475	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HY59_RS24490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HY59_RS24500	COG3852	Histidine kinase
HY59_RS24515	COG2188	Transcriptional regulator
HY59_RS24520	COG1082	Xylose isomerase domain protein TIM barrel
HY59_RS24525	COG2271	Major facilitator Superfamily
HY59_RS24530	COG1011	Hydrolase
HY59_RS24545	COG0456	acetyltransferase
HY59_RS24550	COG0657	acetylesterase activity
HY59_RS24555	COG3058	Necessary for formate dehydrogenase activity
HY59_RS24560	COG2864	formate dehydrogenase
HY59_RS24565	COG0437	4 iron, 4 sulfur cluster binding
HY59_RS24570	COG0243	molybdopterin cofactor binding
HY59_RS24570	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS24575	COG0243	molybdopterin cofactor binding
HY59_RS24575	COG3383	formate dehydrogenase (NAD+) activity
HY59_RS24590	COG0205	6-phosphofructokinase activity
HY59_RS24630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HY59_RS24650	COG2211	Major facilitator Superfamily
HY59_RS24660	COG1454	alcohol dehydrogenase
HY59_RS24670	COG1172	Belongs to the binding-protein-dependent transport system permease family
HY59_RS24675	COG1129	ABC transporter
HY59_RS24715	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HY59_RS24720	COG2258	MOSC domain
HY59_RS24725	COG2205	protein histidine kinase activity
HY59_RS24730	COG0745	RESPONSE REGULATOR receiver
HY59_RS24735	COG3678	ATP-independent chaperone mediated protein folding
HY59_RS24755	COG1575	Belongs to the MenA family. Type 1 subfamily
HY59_RS24770	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HY59_RS24775	COG1609	Transcriptional regulator
HY59_RS24780	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HY59_RS24795	COG0626	cystathionine gamma-synthase activity
HY59_RS24800	COG0460	homoserine dehydrogenase
HY59_RS24800	COG0527	aspartate kinase activity
HY59_RS24810	COG0583	DNA-binding transcription factor activity
HY59_RS24820	COG0371	Dehydrogenase
HY59_RS24830	COG2207	Transcriptional regulator
HY59_RS24835	COG3443	Belongs to the bacterial solute-binding protein 9 family
HY59_RS24850	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HY59_RS24865	COG0583	DNA-binding transcription factor activity