locus-tag	class	description
C1I64_RS00030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1I64_RS00045	COG1396	sequence-specific DNA binding
C1I64_RS00055	COG0657	acetylesterase activity
C1I64_RS00060	COG0697	spore germination
C1I64_RS00070	COG0513	Belongs to the DEAD box helicase family
C1I64_RS00090	COG2372	response to copper ion
C1I64_RS00095	COG0546	phosphoglycolate phosphatase activity
C1I64_RS00115	COG0583	DNA-binding transcription factor activity
C1I64_RS00135	COG0464	growth
C1I64_RS00145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1I64_RS00210	COG0515	serine threonine protein kinase
C1I64_RS00215	COG0395	ABC-type sugar transport system, permease component
C1I64_RS00220	COG1175	transmembrane transport
C1I64_RS00230	COG0431	NADPH-dependent FMN reductase
C1I64_RS00265	COG1305	Transglutaminase-like
C1I64_RS00285	COG0588	phosphoglycerate mutase activity
C1I64_RS00305	COG3239	Fatty acid desaturase
C1I64_RS00310	COG1842	Phage shock protein A
C1I64_RS00320	COG1902	pentaerythritol trinitrate reductase activity
C1I64_RS00335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS00345	COG2851	Citrate transporter
C1I64_RS00350	COG3290	protein histidine kinase activity
C1I64_RS00380	COG2189	Belongs to the N(4) N(6)-methyltransferase family
C1I64_RS00395	COG2723	6-phospho-beta-galactosidase activity
C1I64_RS00405	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1I64_RS00410	COG1876	peptidase activity
C1I64_RS00435	COG3237	CsbD-like
C1I64_RS00465	COG1595	DNA-templated transcription, initiation
C1I64_RS00480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1I64_RS00500	COG0077	Prephenate dehydratase
C1I64_RS00520	COG1024	Enoyl-CoA hydratase
C1I64_RS00525	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C1I64_RS00530	COG0561	phosphatase activity
C1I64_RS00570	COG1316	TRANSCRIPTIONal
C1I64_RS00575	COG1316	TRANSCRIPTIONal
C1I64_RS00590	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1I64_RS00595	COG1201	RNA secondary structure unwinding
C1I64_RS00620	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS00665	COG0085	RNA polymerase activity
C1I64_RS00670	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C1I64_RS00700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1I64_RS00705	COG0765	amino acid transport
C1I64_RS00710	COG1126	abc transporter atp-binding protein
C1I64_RS00725	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C1I64_RS00730	COG0049	tRNA binding
C1I64_RS00735	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C1I64_RS00740	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C1I64_RS00760	COG0051	transcription antitermination factor activity, RNA binding
C1I64_RS00765	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C1I64_RS00770	COG0088	Forms part of the polypeptide exit tunnel
C1I64_RS00775	COG0089	rRNA binding
C1I64_RS00780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C1I64_RS00785	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1I64_RS00790	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
C1I64_RS00795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C1I64_RS00800	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C1I64_RS00805	COG0255	Belongs to the universal ribosomal protein uL29 family
C1I64_RS00810	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C1I64_RS00815	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C1I64_RS00820	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
C1I64_RS00825	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C1I64_RS00830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C1I64_RS00835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C1I64_RS00840	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C1I64_RS00845	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1I64_RS00850	COG1841	ribosomal large subunit assembly
C1I64_RS00855	COG0200	Binds to the 23S rRNA
C1I64_RS00865	COG0563	adenylate kinase activity
C1I64_RS00870	COG0024	Methionine aminopeptidase
C1I64_RS00890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1I64_RS00895	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1I64_RS00910	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1I64_RS00915	COG0246	Mannitol dehydrogenase
C1I64_RS00925	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C1I64_RS00935	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C1I64_RS00940	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C1I64_RS00945	COG0202	RNA polymerase activity
C1I64_RS00950	COG0203	ribosomal protein L17
C1I64_RS00960	COG0101	tRNA pseudouridine synthase activity
C1I64_RS00970	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C1I64_RS00975	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C1I64_RS00980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1I64_RS00985	COG1072	(Pantothenic acid kinase))
C1I64_RS00990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C1I64_RS00995	COG0736	holo-[acyl-carrier-protein] synthase activity
C1I64_RS01000	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C1I64_RS01005	COG0802	atpase or kinase
C1I64_RS01015	COG0456	acetyltransferase
C1I64_RS01020	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C1I64_RS01050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
C1I64_RS01100	COG0516	GMP reductase activity
C1I64_RS01115	COG0475	glutathione-regulated potassium exporter activity
C1I64_RS01130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C1I64_RS01130	COG0519	Catalyzes the synthesis of GMP from XMP
C1I64_RS01150	COG0584	glycerophosphoryl diester phosphodiesterase
C1I64_RS01195	COG0045	succinate-CoA ligase (ADP-forming) activity
C1I64_RS01205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS01225	COG0138	bifunctional purine biosynthesis protein purh
C1I64_RS01230	COG1834	amidinotransferase
C1I64_RS01235	COG1132	(ABC) transporter
C1I64_RS01240	COG1132	(ABC) transporter
C1I64_RS01280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C1I64_RS01285	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C1I64_RS01295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C1I64_RS01300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C1I64_RS01305	COG1064	alcohol dehydrogenase
C1I64_RS01315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C1I64_RS01325	COG1349	DNA-binding transcription factor activity
C1I64_RS01330	COG2017	converts alpha-aldose to the beta-anomer
C1I64_RS01335	COG2733	membrane
C1I64_RS01370	COG1192	Involved in chromosome partitioning
C1I64_RS01400	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1I64_RS01425	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1I64_RS01430	COG0456	acetyltransferase
C1I64_RS01430	COG0454	-acetyltransferase
C1I64_RS01435	COG0745	RESPONSE REGULATOR receiver
C1I64_RS01445	COG3485	protocatechuate 3,4-dioxygenase
C1I64_RS01450	COG0354	folic acid binding
C1I64_RS01475	COG0588	phosphoglycerate mutase activity
C1I64_RS01485	COG5002	protein histidine kinase activity
C1I64_RS01505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C1I64_RS01505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C1I64_RS01510	COG0215	cysteine-tRNA ligase activity
C1I64_RS01515	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1I64_RS01525	COG3842	ATPase activity
C1I64_RS01535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1I64_RS01550	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1I64_RS01570	COG1278	Cold shock
C1I64_RS01575	COG0459	protein refolding
C1I64_RS01585	COG2205	protein histidine kinase activity
C1I64_RS01590	COG0745	RESPONSE REGULATOR receiver
C1I64_RS01615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C1I64_RS01625	COG3883	PFAM NLP P60 protein
C1I64_RS01625	COG0791	NLP P60 protein
C1I64_RS01635	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C1I64_RS01645	COG1131	(ABC) transporter
C1I64_RS01650	COG1725	Transcriptional regulator
C1I64_RS01680	COG1175	transmembrane transport
C1I64_RS01685	COG0395	ABC-type sugar transport system, permease component
C1I64_RS01690	COG0457	Tetratricopeptide repeat
C1I64_RS01695	COG2017	converts alpha-aldose to the beta-anomer
C1I64_RS01750	COG2205	protein histidine kinase activity
C1I64_RS01755	COG0745	RESPONSE REGULATOR receiver
C1I64_RS01775	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1I64_RS01780	COG2072	flavoprotein involved in K transport
C1I64_RS01790	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
C1I64_RS01795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS01805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1I64_RS01825	COG2195	Cleaves the N-terminal amino acid of tripeptides
C1I64_RS01840	COG0586	Pfam SNARE associated Golgi protein
C1I64_RS01890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1I64_RS01930	COG0183	Belongs to the thiolase family
C1I64_RS01940	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS01975	COG2890	protein-(glutamine-N5) methyltransferase activity
C1I64_RS01980	COG0328	RNA-DNA hybrid ribonuclease activity
C1I64_RS02005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
C1I64_RS02025	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C1I64_RS02030	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C1I64_RS02035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C1I64_RS02075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1I64_RS02095	COG1011	Hydrolase
C1I64_RS02100	COG0180	Tryptophanyl-tRNA synthetase
C1I64_RS02110	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1I64_RS02110	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1I64_RS02110	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C1I64_RS02130	COG1349	DNA-binding transcription factor activity
C1I64_RS02145	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C1I64_RS02160	COG2009	succinate dehydrogenase
C1I64_RS02180	COG3845	ABC transporter
C1I64_RS02185	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS02190	COG1079	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS02210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1I64_RS02245	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1I64_RS02260	COG2826	transposase and inactivated derivatives, IS30 family
C1I64_RS02265	COG4770	biotin carboxylase activity
C1I64_RS02270	COG0424	maF-like protein
C1I64_RS02275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C1I64_RS02280	COG2197	response regulator
C1I64_RS02300	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C1I64_RS02305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1I64_RS02330	COG1316	TRANSCRIPTIONal
C1I64_RS02365	COG1216	Glycosyl transferase, family 2
C1I64_RS02385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1I64_RS02395	COG0463	Glycosyl transferase, family 2
C1I64_RS02405	COG0297	glycogen (starch) synthase activity
C1I64_RS02425	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS02460	COG1960	acyl-CoA dehydrogenase activity
C1I64_RS02465	COG1482	cell wall glycoprotein biosynthetic process
C1I64_RS02520	COG0714	Associated with various cellular activities
C1I64_RS02545	COG5002	protein histidine kinase activity
C1I64_RS02550	COG5401	PFAM Sporulation and spore germination
C1I64_RS02555	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1I64_RS02560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1I64_RS02565	COG0653	protein targeting
C1I64_RS02580	COG0395	ABC-type sugar transport system, permease component
C1I64_RS02585	COG1175	transmembrane transport
C1I64_RS02620	COG0667	Aldo Keto reductase
C1I64_RS02640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C1I64_RS02645	COG1595	DNA-templated transcription, initiation
C1I64_RS02655	COG0567	Dehydrogenase, E1 component
C1I64_RS02655	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1I64_RS02665	COG0598	Magnesium transport protein CorA
C1I64_RS02695	COG1017	nitric oxide dioxygenase activity
C1I64_RS02695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1I64_RS02710	COG2814	Major facilitator Superfamily
C1I64_RS02730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
C1I64_RS02740	COG3594	Acyltransferase
C1I64_RS02750	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C1I64_RS02760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C1I64_RS02770	COG1704	LemA family
C1I64_RS02780	COG3214	Protein conserved in bacteria
C1I64_RS02800	COG3842	ATPase activity
C1I64_RS02810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1I64_RS02815	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1I64_RS02840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1I64_RS02845	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C1I64_RS02850	COG1960	acyl-CoA dehydrogenase activity
C1I64_RS02865	COG0114	fumarate hydratase activity
C1I64_RS02880	COG1722	exodeoxyribonuclease VII activity
C1I64_RS02885	COG1570	exodeoxyribonuclease VII activity
C1I64_RS02890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C1I64_RS02900	COG0191	fructose-bisphosphate aldolase activity
C1I64_RS02910	COG1322	Protein conserved in bacteria
C1I64_RS02925	COG0012	GTP binding
C1I64_RS02940	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS02950	COG2326	polyphosphate kinase activity
C1I64_RS02970	COG2814	Major facilitator Superfamily
C1I64_RS02990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C1I64_RS02995	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C1I64_RS03005	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1I64_RS03010	COG0509	glycine decarboxylation via glycine cleavage system
C1I64_RS03015	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1I64_RS03015	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C1I64_RS03025	COG4166	transmembrane transport
C1I64_RS03035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1I64_RS03040	COG4172	Belongs to the ABC transporter superfamily
C1I64_RS03045	COG1217	gtp-binding protein TYPA
C1I64_RS03055	COG2837	iron assimilation
C1I64_RS03060	COG2822	iron ion transport
C1I64_RS03065	COG0672	)-iron permease
C1I64_RS03070	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1I64_RS03090	COG2171	N-acyltransferase activity
C1I64_RS03095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1I64_RS03115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1I64_RS03130	COG2239	Acts as a magnesium transporter
C1I64_RS03140	COG0642	Histidine kinase
C1I64_RS03145	COG0745	RESPONSE REGULATOR receiver
C1I64_RS03165	COG1305	Transglutaminase-like
C1I64_RS03175	COG0018	arginyl-trna synthetase
C1I64_RS03185	COG0019	diaminopimelate decarboxylase activity
C1I64_RS03190	COG0460	homoserine dehydrogenase
C1I64_RS03200	COG0083	homoserine kinase activity
C1I64_RS03210	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C1I64_RS03215	COG2890	protein-(glutamine-N5) methyltransferase activity
C1I64_RS03235	COG2755	lipolytic protein G-D-S-L family
C1I64_RS03235	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C1I64_RS03275	COG1088	dTDP-glucose 4,6-dehydratase activity
C1I64_RS03330	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1I64_RS03340	COG0356	it plays a direct role in the translocation of protons across the membrane
C1I64_RS03345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1I64_RS03350	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C1I64_RS03355	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C1I64_RS03360	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C1I64_RS03365	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C1I64_RS03370	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C1I64_RS03375	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C1I64_RS03380	COG3022	response to hydroperoxide
C1I64_RS03385	COG2818	Glycosylase
C1I64_RS03390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1I64_RS03400	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1I64_RS03410	COG0631	protein serine/threonine phosphatase activity
C1I64_RS03420	COG1674	ftsk spoiiie
C1I64_RS03430	COG3842	ATPase activity
C1I64_RS03435	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1I64_RS03460	COG0204	Acyl-transferase
C1I64_RS03460	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS03465	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1I64_RS03470	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1I64_RS03475	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C1I64_RS03480	COG0750	zinc metalloprotease
C1I64_RS03485	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C1I64_RS03490	COG0442	prolyl-tRNA aminoacylation
C1I64_RS03495	COG0195	Participates in both transcription termination and antitermination
C1I64_RS03505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C1I64_RS03510	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C1I64_RS03515	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
C1I64_RS03535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C1I64_RS03550	COG0196	riboflavin kinase activity
C1I64_RS03555	COG0702	epimerase
C1I64_RS03570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
C1I64_RS03575	COG1937	Protein conserved in bacteria
C1I64_RS03585	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1I64_RS03590	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1I64_RS03590	COG0352	thiamine-phosphate diphosphorylase activity
C1I64_RS03590	COG0351	phosphomethylpyrimidine kinase
C1I64_RS03595	COG0352	thiamine-phosphate diphosphorylase activity
C1I64_RS03600	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C1I64_RS03605	COG0419	ATPase involved in DNA repair
C1I64_RS03615	COG0598	Magnesium transport protein CorA
C1I64_RS03620	COG0723	plastoquinol--plastocyanin reductase activity
C1I64_RS03630	COG3281	Trehalose synthase
C1I64_RS03650	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1I64_RS03655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1I64_RS03660	COG0494	nUDIX hydrolase
C1I64_RS03690	COG0631	protein serine/threonine phosphatase activity
C1I64_RS03700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C1I64_RS03705	COG0066	3-isopropylmalate dehydratase activity
C1I64_RS03710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C1I64_RS03720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C1I64_RS03725	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1I64_RS03730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1I64_RS03745	COG0742	ribosomal rna small subunit methyltransferase
C1I64_RS03750	COG0714	Associated with various cellular activities
C1I64_RS03760	COG1305	Transglutaminase-like
C1I64_RS03765	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C1I64_RS03770	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C1I64_RS03775	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
C1I64_RS03775	COG0778	Nitroreductase
C1I64_RS03780	COG1920	GTP binding
C1I64_RS03790	COG1864	DNA RNA non-specific endonuclease
C1I64_RS03790	COG3591	Belongs to the peptidase S1B family
C1I64_RS03795	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1I64_RS03810	COG2353	YceI-like domain
C1I64_RS03830	COG1125	glycine betaine transport
C1I64_RS03830	COG0517	IMP dehydrogenase activity
C1I64_RS03840	COG1174	glycine betaine transport
C1I64_RS03860	COG1271	oxidase subunit
C1I64_RS03865	COG1294	oxidase, subunit
C1I64_RS03870	COG4988	ABC transporter
C1I64_RS03875	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1I64_RS03925	COG0495	leucyl-tRNA aminoacylation
C1I64_RS03940	COG1596	polysaccharide export
C1I64_RS03940	COG1555	photosystem II stabilization
C1I64_RS03970	COG0268	Binds directly to 16S ribosomal RNA
C1I64_RS03975	COG0436	Aminotransferase
C1I64_RS03985	COG0481	GTPase activity
C1I64_RS04005	COG1420	regulation of RNA biosynthetic process
C1I64_RS04010	COG0484	heat shock protein binding
C1I64_RS04020	COG0537	adenosine 5'-monophosphoramidase activity
C1I64_RS04030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C1I64_RS04040	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C1I64_RS04045	COG4585	Histidine kinase
C1I64_RS04050	COG2197	response regulator
C1I64_RS04055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1I64_RS04065	COG2860	membrane
C1I64_RS04070	COG1381	Involved in DNA repair and RecF pathway recombination
C1I64_RS04075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C1I64_RS04080	COG0673	inositol 2-dehydrogenase activity
C1I64_RS04110	COG0358	DNA primase activity
C1I64_RS04115	COG0747	negative chemotaxis
C1I64_RS04120	COG0601	transmembrane transport
C1I64_RS04150	COG2813	Specifically methylates the guanine in position
C1I64_RS04170	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS04195	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS04200	COG0463	Glycosyl transferase, family 2
C1I64_RS04205	COG0477	Major facilitator Superfamily
C1I64_RS04240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1I64_RS04245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1I64_RS04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1I64_RS04255	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1I64_RS04265	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C1I64_RS04270	COG0450	alkyl hydroperoxide reductase
C1I64_RS04295	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C1I64_RS04310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C1I64_RS04320	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1I64_RS04330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1I64_RS04335	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
C1I64_RS04340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1I64_RS04355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
C1I64_RS04360	COG0571	ribonuclease III activity
C1I64_RS04365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1I64_RS04380	COG3619	membrane
C1I64_RS04395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C1I64_RS04420	COG3835	regulator
C1I64_RS04430	COG0402	S-adenosylhomocysteine deaminase activity
C1I64_RS04440	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1I64_RS04445	COG3608	succinylglutamate desuccinylase aspartoacylase
C1I64_RS04445	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C1I64_RS04465	COG2080	2 iron, 2 sulfur cluster binding
C1I64_RS04465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1I64_RS04475	COG0314	molybdopterin synthase activity
C1I64_RS04480	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1I64_RS04485	COG0315	cyclic pyranopterin monophosphate synthase activity
C1I64_RS04520	COG0552	protein localization to endoplasmic reticulum
C1I64_RS04525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C1I64_RS04530	COG0321	lipoyl(octanoyl) transferase activity
C1I64_RS04555	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1I64_RS04560	COG0228	four-way junction DNA binding
C1I64_RS04565	COG1837	Belongs to the UPF0109 family
C1I64_RS04570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C1I64_RS04575	COG0336	Belongs to the RNA methyltransferase TrmD family
C1I64_RS04595	COG0024	Methionine aminopeptidase
C1I64_RS04605	COG0335	large ribosomal subunit rRNA binding
C1I64_RS04610	COG0681	Belongs to the peptidase S26 family
C1I64_RS04615	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C1I64_RS04625	COG0792	nuclease activity
C1I64_RS04925	COG4974	Belongs to the 'phage' integrase family
C1I64_RS04935	COG0477	Major facilitator Superfamily
C1I64_RS04940	COG0052	Belongs to the universal ribosomal protein uS2 family
C1I64_RS04945	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C1I64_RS04950	COG0528	UMP kinase activity
C1I64_RS04955	COG0233	cytoplasmic translational termination
C1I64_RS04975	COG0025	NhaP-type Na H and K H
C1I64_RS05075	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C1I64_RS05080	COG0366	Alpha amylase catalytic
C1I64_RS05085	COG0058	SHG alpha-glucan phosphorylase activity
C1I64_RS05090	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1I64_RS05105	COG0482	sulfurtransferase activity
C1I64_RS05110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1I64_RS05125	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1I64_RS05130	COG0154	amidase activity
C1I64_RS05135	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C1I64_RS05155	COG1609	Transcriptional regulator
C1I64_RS05165	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS05170	COG0702	epimerase
C1I64_RS05180	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1I64_RS05200	COG4721	ABC-type cobalt transport system, permease component
C1I64_RS05205	COG1122	ATPase activity
C1I64_RS05210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1I64_RS05230	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C1I64_RS05255	COG0667	Aldo Keto reductase
C1I64_RS05260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1I64_RS05265	COG0629	single-stranded DNA binding
C1I64_RS05285	COG1946	Acyl-CoA thioesterase
C1I64_RS05300	COG0668	transmembrane transport
C1I64_RS05305	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1I64_RS05320	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C1I64_RS05335	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C1I64_RS05340	COG0783	Belongs to the Dps family
C1I64_RS05350	COG2197	response regulator
C1I64_RS05400	COG0544	peptidyl-prolyl cis-trans isomerase activity
C1I64_RS05405	COG0740	serine-type endopeptidase activity
C1I64_RS05410	COG0740	serine-type endopeptidase activity
C1I64_RS05415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C1I64_RS05420	COG3135	benzoate transporter
C1I64_RS05435	COG0525	valine-tRNA ligase activity
C1I64_RS05445	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C1I64_RS05450	COG0285	dihydrofolate synthase activity
C1I64_RS05460	COG0105	UTP biosynthetic process
C1I64_RS05470	COG1530	ribonuclease E activity
C1I64_RS05480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1I64_RS05485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C1I64_RS05490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C1I64_RS05495	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C1I64_RS05505	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C1I64_RS05515	COG0799	negative regulation of ribosome biogenesis
C1I64_RS05530	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C1I64_RS05555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C1I64_RS05565	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1I64_RS05570	COG0174	glutamine synthetase
C1I64_RS05590	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1I64_RS05595	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1I64_RS05600	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1I64_RS05615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1I64_RS05620	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1I64_RS05635	COG0187	DNA topoisomerase II activity
C1I64_RS05640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1I64_RS05665	COG0756	dUTP diphosphatase activity
C1I64_RS05680	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1I64_RS05685	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C1I64_RS05690	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1I64_RS05690	COG1024	Enoyl-CoA hydratase
C1I64_RS05695	COG0183	Belongs to the thiolase family
C1I64_RS05700	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1I64_RS05765	COG0363	glucosamine-6-phosphate deaminase activity
C1I64_RS05790	COG2197	response regulator
C1I64_RS05795	COG2261	transglycosylase associated protein
C1I64_RS05800	COG1053	succinate dehydrogenase
C1I64_RS05805	COG0583	DNA-binding transcription factor activity
C1I64_RS05810	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1I64_RS05815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS05820	COG2814	Major facilitator Superfamily
C1I64_RS05880	COG0405	Gamma-glutamyltransferase
C1I64_RS05905	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1I64_RS05930	COG4152	abc transporter atp-binding protein
C1I64_RS05935	COG2197	response regulator
C1I64_RS05940	COG4585	Histidine kinase
C1I64_RS05945	COG2409	Drug exporters of the RND superfamily
C1I64_RS05970	COG0754	glutathionylspermidine amidase activity
C1I64_RS05980	COG1609	Transcriptional regulator
C1I64_RS05990	COG4209	transmembrane transport
C1I64_RS05995	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06005	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C1I64_RS06010	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C1I64_RS06015	COG2080	2 iron, 2 sulfur cluster binding
C1I64_RS06030	COG3585	molybdate ion transport
C1I64_RS06040	COG0300	oxidoreductase activity
C1I64_RS06045	COG1309	transcriptional regulator
C1I64_RS06055	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS06070	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1I64_RS06095	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS06100	COG2826	transposase and inactivated derivatives, IS30 family
C1I64_RS06120	COG1316	TRANSCRIPTIONal
C1I64_RS06155	COG1309	transcriptional regulator
C1I64_RS06190	COG0702	epimerase
C1I64_RS06205	COG0300	oxidoreductase activity
C1I64_RS06210	COG0583	DNA-binding transcription factor activity
C1I64_RS06225	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06230	COG1175	transmembrane transport
C1I64_RS06245	COG1132	(ABC) transporter
C1I64_RS06265	COG1879	ABC-type sugar transport system periplasmic component
C1I64_RS06270	COG1129	ABC transporter
C1I64_RS06275	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS06280	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS06300	COG3250	beta-galactosidase activity
C1I64_RS06310	COG2072	flavoprotein involved in K transport
C1I64_RS06320	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS06355	COG4948	Mandelate Racemase Muconate Lactonizing
C1I64_RS06360	COG1904	glucuronate isomerase
C1I64_RS06365	COG0246	Mannitol dehydrogenase
C1I64_RS06380	COG0444	Belongs to the ABC transporter superfamily
C1I64_RS06390	COG3507	Belongs to the glycosyl hydrolase 43 family
C1I64_RS06395	COG2211	Major facilitator Superfamily
C1I64_RS06400	COG3250	beta-galactosidase activity
C1I64_RS06410	COG1609	Transcriptional regulator
C1I64_RS06415	COG1129	ABC transporter
C1I64_RS06420	COG4214	carbohydrate transport
C1I64_RS06430	COG2188	Transcriptional regulator
C1I64_RS06435	COG1942	4-Oxalocrotonate Tautomerase
C1I64_RS06440	COG1082	Xylose isomerase domain protein TIM barrel
C1I64_RS06445	COG0673	inositol 2-dehydrogenase activity
C1I64_RS06455	COG3962	Belongs to the TPP enzyme family
C1I64_RS06460	COG3718	enzyme involved in inositol metabolism
C1I64_RS06475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1I64_RS06480	COG2814	Major facilitator Superfamily
C1I64_RS06485	COG2188	Transcriptional regulator
C1I64_RS06490	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1I64_RS06495	COG1607	acyl-coa hydrolase
C1I64_RS06535	COG2367	Beta-lactamase
C1I64_RS06550	COG1733	regulation of RNA biosynthetic process
C1I64_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS06570	COG3940	Belongs to the glycosyl hydrolase 43 family
C1I64_RS06605	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06610	COG4209	transmembrane transport
C1I64_RS06615	COG1609	Transcriptional regulator
C1I64_RS06620	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06625	COG1175	transmembrane transport
C1I64_RS06645	COG1621	beta-fructofuranosidase activity
C1I64_RS06655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1I64_RS06680	COG1609	Transcriptional regulator
C1I64_RS06695	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06700	COG1175	transmembrane transport
C1I64_RS06710	COG1609	Transcriptional regulator
C1I64_RS06740	COG0395	ABC-type sugar transport system, permease component
C1I64_RS06745	COG1175	transmembrane transport
C1I64_RS06755	COG1609	Transcriptional regulator
C1I64_RS06775	COG1136	(ABC) transporter
C1I64_RS06790	COG0477	Major facilitator Superfamily
C1I64_RS06805	COG1262	PFAM Formylglycine-generating sulfatase enzyme
C1I64_RS06835	COG2200	EAL domain
C1I64_RS06850	COG1609	Transcriptional regulator
C1I64_RS06860	COG4149	molybdate abc transporter
C1I64_RS06865	COG3842	ATPase activity
C1I64_RS06875	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1I64_RS07080	COG4221	oxidoreductase activity
C1I64_RS07165	COG1215	transferase activity, transferring glycosyl groups
C1I64_RS07195	COG1063	alcohol dehydrogenase
C1I64_RS07220	COG2814	Major facilitator Superfamily
C1I64_RS07230	COG0789	Transcriptional regulator
C1I64_RS07255	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS07265	COG0667	Aldo Keto reductase
C1I64_RS07280	COG0667	Aldo Keto reductase
C1I64_RS07290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1I64_RS07310	COG1228	amidohydrolase
C1I64_RS07345	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS07365	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS07375	COG1309	transcriptional regulator
C1I64_RS07380	COG4221	oxidoreductase activity
C1I64_RS07390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C1I64_RS07410	COG0667	Aldo Keto reductase
C1I64_RS07420	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS07495	COG0738	Major facilitator superfamily
C1I64_RS07590	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
C1I64_RS07595	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
C1I64_RS07600	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
C1I64_RS07615	COG1063	alcohol dehydrogenase
C1I64_RS07630	COG3639	organic phosphonate transmembrane transporter activity
C1I64_RS07635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
C1I64_RS07640	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
C1I64_RS07675	COG0745	RESPONSE REGULATOR receiver
C1I64_RS07685	COG0586	Pfam SNARE associated Golgi protein
C1I64_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS07745	COG4581	dead DEAH box helicase
C1I64_RS07750	COG0805	protein transport
C1I64_RS07755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1I64_RS07775	COG0545	Peptidyl-prolyl cis-trans isomerase
C1I64_RS07795	COG0215	cysteine-tRNA ligase activity
C1I64_RS07800	COG1968	undecaprenyl-diphosphatase activity
C1I64_RS07805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1I64_RS07815	COG3896	Chloramphenicol phosphotransferase-like protein
C1I64_RS07820	COG3250	beta-galactosidase activity
C1I64_RS07825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS07840	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C1I64_RS07855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1I64_RS07860	COG0587	DNA-directed DNA polymerase activity
C1I64_RS07915	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS07920	COG0596	Alpha beta hydrolase
C1I64_RS07925	COG0366	Alpha amylase catalytic
C1I64_RS07940	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1I64_RS07945	COG0254	rRNA binding
C1I64_RS07950	COG1119	ATPase activity
C1I64_RS07955	COG0297	glycogen (starch) synthase activity
C1I64_RS07960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C1I64_RS07965	COG0560	Phosphoserine phosphatase
C1I64_RS07965	COG3830	Belongs to the UPF0237 family
C1I64_RS08000	COG0488	(ABC) transporter
C1I64_RS08005	COG1268	BioY protein
C1I64_RS08010	COG2151	metal-sulfur cluster biosynthetic enzyme
C1I64_RS08015	COG0396	ATPase activity
C1I64_RS08020	COG2146	nitrite reductase [NAD(P)H] activity
C1I64_RS08025	COG0719	Fe-S assembly protein
C1I64_RS08045	COG0109	protoheme IX farnesyltransferase activity
C1I64_RS08055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C1I64_RS08060	COG0166	Belongs to the GPI family
C1I64_RS08075	COG0363	glucosamine-6-phosphate deaminase activity
C1I64_RS08085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1I64_RS08090	COG0149	triose-phosphate isomerase activity
C1I64_RS08095	COG0126	phosphoglycerate kinase activity
C1I64_RS08110	COG1481	regulation of sporulation
C1I64_RS08115	COG1660	Displays ATPase and GTPase activities
C1I64_RS08120	COG0322	excinuclease ABC activity
C1I64_RS08130	COG0556	nucleotide-excision repair
C1I64_RS08140	COG0237	dephospho-CoA kinase activity
C1I64_RS08145	COG0539	negative regulation of cytoplasmic translation
C1I64_RS08160	COG2050	protein possibly involved in aromatic compounds catabolism
C1I64_RS08195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS08200	COG2873	o-acetylhomoserine
C1I64_RS08235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1I64_RS08245	COG0248	Ppx GppA phosphatase
C1I64_RS08260	COG0067	glutamate synthase
C1I64_RS08260	COG0070	glutamate synthase
C1I64_RS08260	COG0069	glutamate synthase activity
C1I64_RS08265	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C1I64_RS08270	COG0159	tryptophan synthase activity
C1I64_RS08275	COG0133	tryptophan synthase activity
C1I64_RS08280	COG0134	indole-3-glycerol-phosphate synthase activity
C1I64_RS08295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C1I64_RS08300	COG0107	imidazoleglycerol-phosphate synthase activity
C1I64_RS08305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C1I64_RS08310	COG0140	phosphoribosyl-ATP diphosphatase activity
C1I64_RS08315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C1I64_RS08325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C1I64_RS08335	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1I64_RS08345	COG1758	RNA polymerase activity
C1I64_RS08350	COG0194	GDP metabolic process
C1I64_RS08355	COG0284	orotidine-5'-phosphate decarboxylase activity
C1I64_RS08360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1I64_RS08365	COG0505	Belongs to the CarA family
C1I64_RS08375	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1I64_RS08380	COG0540	Belongs to the ATCase OTCase family
C1I64_RS08385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C1I64_RS08390	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1I64_RS08395	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C1I64_RS08405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C1I64_RS08410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C1I64_RS08415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C1I64_RS08420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1I64_RS08430	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C1I64_RS08435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1I64_RS08450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C1I64_RS08465	COG1196	nuclear chromosome segregation
C1I64_RS08475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C1I64_RS08485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1I64_RS08490	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C1I64_RS08500	COG2255	four-way junction helicase activity
C1I64_RS08505	COG0632	four-way junction helicase activity
C1I64_RS08510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
C1I64_RS08515	COG0217	transcriptional regulatory protein
C1I64_RS08540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C1I64_RS08550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C1I64_RS08555	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C1I64_RS08565	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C1I64_RS08570	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C1I64_RS08575	COG0673	inositol 2-dehydrogenase activity
C1I64_RS08605	COG1215	transferase activity, transferring glycosyl groups
C1I64_RS08640	COG2807	transmembrane transport
C1I64_RS08645	COG1295	ribonuclease BN
C1I64_RS08660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1I64_RS08665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1I64_RS08700	COG0277	FAD linked oxidase domain protein
C1I64_RS08715	COG1597	lipid kinase activity
C1I64_RS08725	COG1461	Dihydroxyacetone kinase
C1I64_RS08730	COG2376	Dihydroxyacetone kinase
C1I64_RS08735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C1I64_RS08740	COG1845	cytochrome c oxidase, subunit III
C1I64_RS08745	COG2010	Cytochrome c
C1I64_RS08750	COG0723	plastoquinol--plastocyanin reductase activity
C1I64_RS08755	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1I64_RS08765	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1I64_RS08770	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1I64_RS08780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1I64_RS08790	COG0167	dihydroorotate dehydrogenase activity
C1I64_RS08795	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C1I64_RS08800	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C1I64_RS08815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C1I64_RS08830	COG1799	cell septum assembly
C1I64_RS08840	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1I64_RS08850	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C1I64_RS08855	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1I64_RS08865	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C1I64_RS08870	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1I64_RS08880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1I64_RS08885	COG0768	penicillin binding
C1I64_RS08895	COG0275	rRNA processing
C1I64_RS08900	COG2001	Belongs to the MraZ family
C1I64_RS08910	COG0142	geranyltranstransferase activity
C1I64_RS08925	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1I64_RS08930	COG0204	Acyl-transferase
C1I64_RS08930	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS08935	COG1940	carbohydrate kinase activity
C1I64_RS08960	COG1192	Involved in chromosome partitioning
C1I64_RS08975	COG1716	ATPase activity
C1I64_RS08985	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1I64_RS08990	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
C1I64_RS08995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1I64_RS09025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS09035	COG0484	heat shock protein binding
C1I64_RS09040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS09055	COG1522	sequence-specific DNA binding
C1I64_RS09065	COG3265	gluconokinase activity
C1I64_RS09075	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1I64_RS09085	COG3012	SEC-C Motif Domain Protein
C1I64_RS09100	COG1175	transmembrane transport
C1I64_RS09110	COG1609	Transcriptional regulator
C1I64_RS09150	COG1793	dna ligase
C1I64_RS09175	COG0277	FAD linked oxidase domain protein
C1I64_RS09200	COG0601	transmembrane transport
C1I64_RS09205	COG0747	negative chemotaxis
C1I64_RS09210	COG1960	acyl-CoA dehydrogenase activity
C1I64_RS09215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS09220	COG0583	DNA-binding transcription factor activity
C1I64_RS09260	COG0137	argininosuccinate synthase activity
C1I64_RS09275	COG2130	NADP-dependent
C1I64_RS09280	COG2084	Dehydrogenase
C1I64_RS09290	COG0149	triose-phosphate isomerase activity
C1I64_RS09295	COG0698	ribose 5-phosphate isomerase
C1I64_RS09300	COG2376	Dihydroxyacetone kinase
C1I64_RS09310	COG2186	Transcriptional regulator
C1I64_RS09320	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1I64_RS09325	COG1136	(ABC) transporter
C1I64_RS09325	COG0577	efflux transmembrane transporter activity
C1I64_RS09330	COG0577	efflux transmembrane transporter activity
C1I64_RS09330	COG1136	(ABC) transporter
C1I64_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS09415	COG0531	amino acid
C1I64_RS09440	COG2311	Membrane
C1I64_RS09450	COG1131	(ABC) transporter
C1I64_RS09475	COG1160	GTP binding
C1I64_RS09480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C1I64_RS09495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1I64_RS09500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1I64_RS09510	COG4974	Belongs to the 'phage' integrase family
C1I64_RS09515	COG0494	nUDIX hydrolase
C1I64_RS09520	COG0504	CTP synthase activity
C1I64_RS09525	COG0497	DNA recombination
C1I64_RS09530	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1I64_RS09555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C1I64_RS09570	COG2094	Belongs to the DNA glycosylase MPG family
C1I64_RS09575	COG0165	Argininosuccinate lyase
C1I64_RS09580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C1I64_RS09585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1I64_RS09590	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C1I64_RS09595	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C1I64_RS09600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C1I64_RS09605	COG0072	phenylalanine-tRNA ligase activity
C1I64_RS09605	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1I64_RS09610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C1I64_RS09615	COG0765	amino acid transport
C1I64_RS09620	COG0765	amino acid transport
C1I64_RS09625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1I64_RS09630	COG1126	abc transporter atp-binding protein
C1I64_RS09635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1I64_RS09640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C1I64_RS09645	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C1I64_RS09650	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1I64_RS09665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C1I64_RS09670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C1I64_RS09675	COG0131	Imidazoleglycerol-phosphate dehydratase
C1I64_RS09680	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1I64_RS09690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C1I64_RS09695	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1I64_RS09705	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C1I64_RS09710	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C1I64_RS09715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1I64_RS09720	COG2137	regulation of response to DNA damage stimulus
C1I64_RS09725	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1I64_RS09735	COG1396	sequence-specific DNA binding
C1I64_RS09740	COG1546	Belongs to the CinA family
C1I64_RS09740	COG1058	Belongs to the CinA family
C1I64_RS09750	COG1674	ftsk spoiiie
C1I64_RS09760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C1I64_RS09765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1I64_RS09775	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
C1I64_RS09800	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C1I64_RS09805	COG0406	alpha-ribazole phosphatase activity
C1I64_RS09810	COG0612	Peptidase, M16
C1I64_RS09815	COG0667	Aldo Keto reductase
C1I64_RS09820	COG0366	Alpha amylase catalytic
C1I64_RS09825	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS09830	COG1185	polyribonucleotide nucleotidyltransferase activity
C1I64_RS09850	COG0583	DNA-binding transcription factor activity
C1I64_RS09880	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C1I64_RS09910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1I64_RS09925	COG0545	Peptidyl-prolyl cis-trans isomerase
C1I64_RS09935	COG2205	protein histidine kinase activity
C1I64_RS09940	COG0745	RESPONSE REGULATOR receiver
C1I64_RS09955	COG1132	(ABC) transporter
C1I64_RS09960	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS10005	COG0174	glutamine synthetase
C1I64_RS10010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1I64_RS10015	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS10020	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS10025	COG2186	Transcriptional regulator
C1I64_RS10050	COG0596	Alpha beta hydrolase
C1I64_RS10055	COG0604	alcohol dehydrogenase
C1I64_RS10070	COG2267	carboxylic ester hydrolase activity
C1I64_RS10075	COG0277	FAD linked oxidase domain protein
C1I64_RS10080	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1I64_RS10085	COG0531	amino acid
C1I64_RS10115	COG2268	Band 7 protein
C1I64_RS10125	COG3634	alkyl hydroperoxide reductase activity
C1I64_RS10130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1I64_RS10145	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
C1I64_RS10150	COG0859	PFAM glycosyl transferase family 9
C1I64_RS10160	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS10165	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
C1I64_RS10170	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1I64_RS10170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1I64_RS10175	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS10180	COG0859	PFAM glycosyl transferase family 9
C1I64_RS10185	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS10190	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS10200	COG2072	flavoprotein involved in K transport
C1I64_RS10210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1I64_RS10225	COG2144	transferase activity, transferring acyl groups
C1I64_RS10230	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS10235	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C1I64_RS10235	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C1I64_RS10250	COG0514	ATP-dependent DNA helicase (RecQ)
C1I64_RS10260	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1I64_RS10265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C1I64_RS10270	COG0473	3-isopropylmalate dehydrogenase activity
C1I64_RS10275	COG0477	Major facilitator Superfamily
C1I64_RS10285	COG0384	phenazine biosynthesis protein PhzF
C1I64_RS10315	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C1I64_RS10320	COG0440	acetolactate synthase activity
C1I64_RS10330	COG0129	dihydroxy-acid dehydratase activity
C1I64_RS10365	COG1263	PTS System
C1I64_RS10365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1I64_RS10365	COG2190	(PTS) system
C1I64_RS10370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1I64_RS10370	COG2190	(PTS) system
C1I64_RS10370	COG1263	PTS System
C1I64_RS10375	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1I64_RS10380	COG3387	PFAM Glycoside hydrolase 15-related
C1I64_RS10400	COG0483	inositol monophosphate 1-phosphatase activity
C1I64_RS10420	COG0477	Major facilitator Superfamily
C1I64_RS10425	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C1I64_RS10430	COG2177	Part of the ABC transporter FtsEX involved in
C1I64_RS10435	COG2884	Cell division ATP-binding protein ftsE
C1I64_RS10460	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C1I64_RS10475	COG0586	Pfam SNARE associated Golgi protein
C1I64_RS10480	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1I64_RS10485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C1I64_RS10490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C1I64_RS10515	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1I64_RS10520	COG1682	transport, permease protein
C1I64_RS10550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1I64_RS10590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1I64_RS10600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C1I64_RS10605	COG3942	CHAP domain
C1I64_RS10605	COG1388	LysM domain
C1I64_RS10625	COG1615	UPF0182 protein
C1I64_RS10630	COG3480	Lon protease (S16) C-terminal proteolytic domain
C1I64_RS10685	COG2814	Major facilitator Superfamily
C1I64_RS10700	COG0513	Belongs to the DEAD box helicase family
C1I64_RS10715	COG0006	proline dipeptidase activity
C1I64_RS10720	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1I64_RS10770	COG0154	amidase activity
C1I64_RS10785	COG2723	6-phospho-beta-galactosidase activity
C1I64_RS10795	COG1305	Transglutaminase-like
C1I64_RS10830	COG0148	phosphopyruvate hydratase activity
C1I64_RS10835	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C1I64_RS10850	COG1116	anion transmembrane transporter activity
C1I64_RS10860	COG0124	histidyl-tRNA synthetase
C1I64_RS10880	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1I64_RS10890	COG0193	aminoacyl-tRNA hydrolase activity
C1I64_RS10895	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C1I64_RS10900	COG0435	Glutathione S-transferase
C1I64_RS10910	COG0366	Alpha amylase catalytic
C1I64_RS10915	COG0395	ABC-type sugar transport system, permease component
C1I64_RS10920	COG1175	transmembrane transport
C1I64_RS10930	COG1940	carbohydrate kinase activity
C1I64_RS10940	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1I64_RS10945	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C1I64_RS10955	COG1846	Transcriptional regulator
C1I64_RS10960	COG0488	(ABC) transporter
C1I64_RS10970	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C1I64_RS10975	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C1I64_RS10980	COG0084	hydrolase, TatD family'
C1I64_RS10985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1I64_RS11000	COG2855	membrane
C1I64_RS11010	COG1832	CoA-binding protein
C1I64_RS11015	COG1690	Belongs to the RtcB family
C1I64_RS11030	COG1760	l-serine dehydratase
C1I64_RS11040	COG1331	Highly conserved protein containing a thioredoxin domain
C1I64_RS11050	COG1643	Atp-dependent helicase
C1I64_RS11065	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS11075	COG2234	aminopeptidase activity
C1I64_RS11085	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C1I64_RS11115	COG1674	ftsk spoiiie
C1I64_RS11125	COG2815	serine threonine protein kinase
C1I64_RS11125	COG0515	serine threonine protein kinase
C1I64_RS11155	COG0714	Associated with various cellular activities
C1I64_RS11220	COG2258	MOSC domain
C1I64_RS11255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1I64_RS11255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1I64_RS11260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C1I64_RS11265	COG0477	Major facilitator Superfamily
C1I64_RS11270	COG1132	(ABC) transporter
C1I64_RS11285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1I64_RS11295	COG1335	isochorismatase
C1I64_RS11300	COG2027	D-alanyl-D-alanine carboxypeptidase
C1I64_RS11320	COG0470	DNA polymerase III
C1I64_RS11325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C1I64_RS11330	COG1754	DNA topoisomerase type I activity
C1I64_RS11330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1I64_RS11365	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1I64_RS11375	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1I64_RS11380	COG1408	metallophosphoesterase
C1I64_RS11395	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1I64_RS11400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1I64_RS11405	COG0489	protein tyrosine kinase activity
C1I64_RS11405	COG3206	protein involved in exopolysaccharide biosynthesis
C1I64_RS11420	COG1435	thymidine kinase activity
C1I64_RS11435	COG0579	oxidoreductase
C1I64_RS11450	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C1I64_RS11460	COG0746	molybdenum cofactor guanylyltransferase activity
C1I64_RS11470	COG1063	alcohol dehydrogenase
C1I64_RS11475	COG0303	'Molybdopterin
C1I64_RS11485	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C1I64_RS11490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1I64_RS11510	COG0582	viral genome integration into host DNA
C1I64_RS11610	COG0433	COG0433 Predicted ATPase
C1I64_RS11635	COG2814	Major facilitator Superfamily
C1I64_RS11645	COG1501	Belongs to the glycosyl hydrolase 31 family
C1I64_RS11650	COG0395	ABC-type sugar transport system, permease component
C1I64_RS11655	COG1175	transmembrane transport
C1I64_RS11660	COG1653	transport
C1I64_RS11665	COG1609	Transcriptional regulator
C1I64_RS11670	COG2115	Belongs to the xylose isomerase family
C1I64_RS11675	COG1070	Carbohydrate kinase
C1I64_RS11685	COG4175	Glycine betaine
C1I64_RS11685	COG0517	IMP dehydrogenase activity
C1I64_RS11690	COG0406	alpha-ribazole phosphatase activity
C1I64_RS11705	COG1609	Transcriptional regulator
C1I64_RS11710	COG4213	ABC transporter substrate-binding protein
C1I64_RS11720	COG4214	carbohydrate transport
C1I64_RS11770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1I64_RS11780	COG0542	response to heat
C1I64_RS11790	COG4989	oxidoreductase activity
C1I64_RS11800	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1I64_RS11805	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1I64_RS11820	COG1929	Belongs to the glycerate kinase type-1 family
C1I64_RS11835	COG1648	precorrin-2 dehydrogenase activity
C1I64_RS11835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1I64_RS11840	COG2146	nitrite reductase [NAD(P)H] activity
C1I64_RS11840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1I64_RS11850	COG2223	nitrite transmembrane transporter activity
C1I64_RS11855	COG0243	molybdopterin cofactor binding
C1I64_RS11860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1I64_RS11905	COG1132	(ABC) transporter
C1I64_RS11910	COG0395	ABC-type sugar transport system, permease component
C1I64_RS11915	COG1175	transmembrane transport
C1I64_RS11920	COG1653	transport
C1I64_RS11955	COG0222	ribosome binding
C1I64_RS11960	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C1I64_RS11995	COG2261	transglycosylase associated protein
C1I64_RS12000	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS12005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1I64_RS12035	COG0673	inositol 2-dehydrogenase activity
C1I64_RS12040	COG2205	protein histidine kinase activity
C1I64_RS12045	COG0745	RESPONSE REGULATOR receiver
C1I64_RS12050	COG0531	amino acid
C1I64_RS12070	COG1136	(ABC) transporter
C1I64_RS12095	COG0673	inositol 2-dehydrogenase activity
C1I64_RS12100	COG0673	inositol 2-dehydrogenase activity
C1I64_RS12105	COG1082	Xylose isomerase domain protein TIM barrel
C1I64_RS12125	COG0604	alcohol dehydrogenase
C1I64_RS12125	COG3321	synthase
C1I64_RS12135	COG0081	regulation of translation
C1I64_RS12140	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
C1I64_RS12145	COG0250	Participates in transcription elongation, termination and antitermination
C1I64_RS12155	COG0436	Aminotransferase
C1I64_RS12170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C1I64_RS12180	COG2030	dehydratase
C1I64_RS12200	COG1953	Uracil, thiamine, allantoin
C1I64_RS12250	COG1131	(ABC) transporter
C1I64_RS12270	COG0823	Involved in the tonB-independent uptake of proteins
C1I64_RS12275	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1I64_RS12275	COG2111	Na H antiporter
C1I64_RS12280	COG1006	Multisubunit Na H antiporter MnhC subunit
C1I64_RS12285	COG0651	ATP synthesis coupled electron transport
C1I64_RS12305	COG0366	Alpha amylase catalytic
C1I64_RS12310	COG0739	heme binding
C1I64_RS12320	COG0702	epimerase
C1I64_RS12345	COG1666	GTP binding
C1I64_RS12350	COG0494	nUDIX hydrolase
C1I64_RS12370	COG0142	geranyltranstransferase activity
C1I64_RS12375	COG2226	methyltransferase
C1I64_RS12385	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C1I64_RS12415	COG0783	Belongs to the Dps family
C1I64_RS12425	COG3387	PFAM Glycoside hydrolase 15-related
C1I64_RS12435	COG4948	Mandelate Racemase Muconate Lactonizing
C1I64_RS12440	COG2084	Dehydrogenase
C1I64_RS12450	COG2186	Transcriptional regulator
C1I64_RS12455	COG1957	nucleoside hydrolase
C1I64_RS12460	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1I64_RS12470	COG0785	Cytochrome C biogenesis protein
C1I64_RS12480	COG0406	alpha-ribazole phosphatase activity
C1I64_RS12485	COG4221	oxidoreductase activity
C1I64_RS12490	COG1136	(ABC) transporter
C1I64_RS12500	COG4585	Histidine kinase
C1I64_RS12505	COG2197	response regulator
C1I64_RS12520	COG0017	Asparaginyl-tRNA synthetase
C1I64_RS12545	COG0395	ABC-type sugar transport system, permease component
C1I64_RS12575	COG0640	Transcriptional regulator
C1I64_RS12580	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1I64_RS12585	COG0569	domain protein
C1I64_RS12595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1I64_RS12610	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C1I64_RS12615	COG0745	RESPONSE REGULATOR receiver
C1I64_RS12655	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C1I64_RS12680	COG0415	Belongs to the DNA photolyase family
C1I64_RS12685	COG1045	serine acetyltransferase
C1I64_RS12695	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C1I64_RS12700	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1I64_RS12715	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS12725	COG0697	spore germination
C1I64_RS12745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C1I64_RS12750	COG0297	glycogen (starch) synthase activity
C1I64_RS12765	COG1695	Transcriptional regulator
C1I64_RS12770	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1I64_RS12775	COG0318	PFAM AMP-dependent synthetase and ligase
C1I64_RS12780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1I64_RS12785	COG0232	Belongs to the dGTPase family. Type 2 subfamily
C1I64_RS12820	COG2267	carboxylic ester hydrolase activity
C1I64_RS12860	COG2815	serine threonine protein kinase
C1I64_RS12860	COG0515	serine threonine protein kinase
C1I64_RS12885	COG3537	Alpha-1,2-mannosidase
C1I64_RS12925	COG1902	pentaerythritol trinitrate reductase activity
C1I64_RS12945	COG4608	Belongs to the ABC transporter superfamily
C1I64_RS12990	COG2233	PERMEase
C1I64_RS13010	COG3546	catalase activity
C1I64_RS13015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C1I64_RS13020	COG4133	protoheme IX ABC transporter activity
C1I64_RS13035	COG3655	Transcriptional regulator
C1I64_RS13045	COG0154	amidase activity
C1I64_RS13095	COG3711	transcriptional antiterminator
C1I64_RS13100	COG2723	6-phospho-beta-galactosidase activity
C1I64_RS13105	COG1263	PTS System
C1I64_RS13105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1I64_RS13105	COG2190	(PTS) system
C1I64_RS13110	COG0494	nUDIX hydrolase
C1I64_RS13160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1I64_RS13170	COG4166	transmembrane transport
C1I64_RS13195	COG2814	Major facilitator Superfamily
C1I64_RS13200	COG0583	DNA-binding transcription factor activity
C1I64_RS13220	COG3250	beta-galactosidase activity
C1I64_RS13225	COG1609	Transcriptional regulator
C1I64_RS13230	COG1653	transport
C1I64_RS13235	COG1175	transmembrane transport
C1I64_RS13240	COG0395	ABC-type sugar transport system, permease component
C1I64_RS13255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1I64_RS13260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1I64_RS13265	COG0738	Major facilitator superfamily
C1I64_RS13270	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS13290	COG1595	DNA-templated transcription, initiation
C1I64_RS13295	COG0477	Major facilitator Superfamily
C1I64_RS13300	COG1309	transcriptional regulator
C1I64_RS13320	COG1846	Transcriptional regulator
C1I64_RS13365	COG0673	inositol 2-dehydrogenase activity
C1I64_RS13370	COG1609	Transcriptional regulator
C1I64_RS13375	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS13390	COG1129	ABC transporter
C1I64_RS13395	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS13400	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS13415	COG1595	DNA-templated transcription, initiation
C1I64_RS13430	COG2814	Major facilitator Superfamily
C1I64_RS13485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C1I64_RS13505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C1I64_RS13525	COG1316	TRANSCRIPTIONal
C1I64_RS13535	COG1252	NADH dehydrogenase
C1I64_RS13545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1I64_RS13560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C1I64_RS13565	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C1I64_RS13590	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1I64_RS13595	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C1I64_RS13600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1I64_RS13605	COG0302	gtp cyclohydrolase
C1I64_RS13610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1I64_RS13615	COG1511	domain protein
C1I64_RS13625	COG1597	lipid kinase activity
C1I64_RS13640	COG0037	tRNA processing
C1I64_RS13645	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1I64_RS13655	COG0741	lytic transglycosylase activity
C1I64_RS13655	COG0739	heme binding
C1I64_RS13655	COG1196	nuclear chromosome segregation
C1I64_RS13680	COG2357	RelA SpoT domain protein
C1I64_RS13690	COG0477	Major facilitator Superfamily
C1I64_RS13715	COG0534	Mate efflux family protein
C1I64_RS13725	COG0039	L-malate dehydrogenase activity
C1I64_RS13740	COG0514	ATP-dependent DNA helicase (RecQ)
C1I64_RS13780	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
C1I64_RS13790	COG0395	ABC-type sugar transport system, permease component
C1I64_RS13795	COG1175	transmembrane transport
C1I64_RS13810	COG1940	carbohydrate kinase activity
C1I64_RS13810	COG1846	Transcriptional regulator
C1I64_RS13820	COG4585	Histidine kinase
C1I64_RS13825	COG1136	(ABC) transporter
C1I64_RS13830	COG0577	efflux transmembrane transporter activity
C1I64_RS13830	COG1136	(ABC) transporter
C1I64_RS13850	COG2814	Major facilitator Superfamily
C1I64_RS13865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1I64_RS13875	COG0747	negative chemotaxis
C1I64_RS13880	COG1609	Transcriptional regulator
C1I64_RS13920	COG2160	L-arabinose isomerase activity
C1I64_RS13940	COG2814	Major facilitator Superfamily
C1I64_RS13965	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS13970	COG1472	Belongs to the glycosyl hydrolase 3 family
C1I64_RS13975	COG0395	ABC-type sugar transport system, permease component
C1I64_RS14020	COG0129	dihydroxy-acid dehydratase activity
C1I64_RS14050	COG0395	ABC-type sugar transport system, permease component
C1I64_RS14055	COG4209	transmembrane transport
C1I64_RS14070	COG1621	beta-fructofuranosidase activity
C1I64_RS14080	COG1609	Transcriptional regulator
C1I64_RS14130	COG1609	Transcriptional regulator
C1I64_RS14145	COG0673	inositol 2-dehydrogenase activity
C1I64_RS14160	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C1I64_RS14185	COG3347	Dehydrogenase
C1I64_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14190	COG1070	Carbohydrate kinase
C1I64_RS14225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1I64_RS14235	COG0604	alcohol dehydrogenase
C1I64_RS14235	COG3321	synthase
C1I64_RS14235	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14245	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1I64_RS14290	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1I64_RS14295	COG1120	ATPase activity
C1I64_RS14300	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14305	COG1362	aminopeptidase activity
C1I64_RS14325	COG2207	Transcriptional regulator
C1I64_RS14345	COG0673	inositol 2-dehydrogenase activity
C1I64_RS14355	COG1309	transcriptional regulator
C1I64_RS14360	COG2267	carboxylic ester hydrolase activity
C1I64_RS14365	COG3321	synthase
C1I64_RS14365	COG0604	alcohol dehydrogenase
C1I64_RS14370	COG0395	ABC-type sugar transport system, permease component
C1I64_RS14375	COG1175	transmembrane transport
C1I64_RS14390	COG1609	Transcriptional regulator
C1I64_RS14400	COG0745	RESPONSE REGULATOR receiver
C1I64_RS14405	COG2205	protein histidine kinase activity
C1I64_RS14420	COG1175	transmembrane transport
C1I64_RS14425	COG0395	ABC-type sugar transport system, permease component
C1I64_RS14430	COG3835	regulator
C1I64_RS14460	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
C1I64_RS14470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1I64_RS14485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C1I64_RS14495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
C1I64_RS14505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1I64_RS14530	COG0583	DNA-binding transcription factor activity
C1I64_RS14545	COG0300	oxidoreductase activity
C1I64_RS14550	COG0277	FAD linked oxidase domain protein
C1I64_RS14560	COG1940	carbohydrate kinase activity
C1I64_RS14570	COG1175	transmembrane transport
C1I64_RS14575	COG2182	Extracellular solute-binding protein
C1I64_RS14580	COG3525	Glycosyl hydrolase, family 20, catalytic domain
C1I64_RS14590	COG3546	catalase activity
C1I64_RS14595	COG0656	L-ascorbic acid biosynthetic process
C1I64_RS14600	COG1609	Transcriptional regulator
C1I64_RS14610	COG1253	flavin adenine dinucleotide binding
C1I64_RS14620	COG0477	Major facilitator Superfamily
C1I64_RS14635	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C1I64_RS14640	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1I64_RS14645	COG1834	amidinotransferase
C1I64_RS14650	COG1940	carbohydrate kinase activity
C1I64_RS14660	COG1819	glycosyl
C1I64_RS14670	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C1I64_RS14670	COG1796	DNA polymerase
C1I64_RS14695	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14700	COG2271	Major facilitator Superfamily
C1I64_RS14710	COG0698	ribose 5-phosphate isomerase
C1I64_RS14715	COG2376	Dihydroxyacetone kinase
C1I64_RS14725	COG2130	NADP-dependent
C1I64_RS14735	COG1846	Transcriptional regulator
C1I64_RS14745	COG0531	amino acid
C1I64_RS14775	COG2267	carboxylic ester hydrolase activity
C1I64_RS14780	COG3833	ABC-type maltose transport systems, permease component
C1I64_RS14785	COG1175	transmembrane transport
C1I64_RS14795	COG1609	Transcriptional regulator
C1I64_RS14830	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C1I64_RS14855	COG0737	Belongs to the 5'-nucleotidase family
C1I64_RS14865	COG0151	Belongs to the GarS family
C1I64_RS14875	COG1216	Glycosyl transferase, family 2
C1I64_RS14890	COG1090	epimerase
C1I64_RS14905	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS14935	COG0386	Belongs to the glutathione peroxidase family
C1I64_RS14965	COG1902	pentaerythritol trinitrate reductase activity
C1I64_RS14975	COG1126	abc transporter atp-binding protein
C1I64_RS14980	COG0765	amino acid transport
C1I64_RS15015	COG0747	negative chemotaxis
C1I64_RS15025	COG0444	Belongs to the ABC transporter superfamily
C1I64_RS15035	COG0402	S-adenosylhomocysteine deaminase activity
C1I64_RS15040	COG0596	Alpha beta hydrolase
C1I64_RS15045	COG2808	Putative FMN-binding domain
C1I64_RS15050	COG1473	amidohydrolase
C1I64_RS15085	COG3534	alpha-L-arabinofuranosidase
C1I64_RS15090	COG0395	ABC-type sugar transport system, permease component
C1I64_RS15095	COG1175	transmembrane transport
C1I64_RS15105	COG1609	Transcriptional regulator
C1I64_RS15120	COG0745	RESPONSE REGULATOR receiver
C1I64_RS15145	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS15150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C1I64_RS15175	COG0647	UMP catabolic process
C1I64_RS15205	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C1I64_RS15220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1I64_RS15225	COG2514	catechol 2,3-dioxygenase activity
C1I64_RS15230	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1I64_RS15235	COG0047	phosphoribosylformylglycinamidine synthase activity
C1I64_RS15255	COG1120	ATPase activity
C1I64_RS15260	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1I64_RS15265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1I64_RS15285	COG4552	Acetyltransferase involved in intracellular survival and related
C1I64_RS15295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1I64_RS15320	COG0667	Aldo Keto reductase
C1I64_RS15330	COG0583	DNA-binding transcription factor activity
C1I64_RS15350	COG4608	Belongs to the ABC transporter superfamily
C1I64_RS15355	COG0444	Belongs to the ABC transporter superfamily
C1I64_RS15360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1I64_RS15365	COG0601	transmembrane transport
C1I64_RS15370	COG0163	prenyltransferase activity
C1I64_RS15380	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C1I64_RS15385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1I64_RS15400	COG4166	transmembrane transport
C1I64_RS15415	COG2084	Dehydrogenase
C1I64_RS15420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1I64_RS15435	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS15440	COG1063	alcohol dehydrogenase
C1I64_RS15445	COG0287	Prephenate dehydrogenase
C1I64_RS15445	COG1605	Chorismate mutase
C1I64_RS15450	COG1764	response to oxidative stress
C1I64_RS15515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1I64_RS15515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1I64_RS15545	COG0577	efflux transmembrane transporter activity
C1I64_RS15550	COG1136	(ABC) transporter
C1I64_RS15550	COG0577	efflux transmembrane transporter activity
C1I64_RS15560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
C1I64_RS15565	COG0737	Belongs to the 5'-nucleotidase family
C1I64_RS15580	COG2315	Protein conserved in bacteria
C1I64_RS15600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1I64_RS15610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C1I64_RS15655	COG1136	(ABC) transporter
C1I64_RS15680	COG4585	Histidine kinase
C1I64_RS15685	COG2197	response regulator
C1I64_RS15720	COG1116	anion transmembrane transporter activity
C1I64_RS15730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1I64_RS15735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1I64_RS15750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C1I64_RS15760	COG0657	acetylesterase activity
C1I64_RS15770	COG1063	alcohol dehydrogenase
C1I64_RS15780	COG0542	response to heat
C1I64_RS15800	COG1902	pentaerythritol trinitrate reductase activity
C1I64_RS15815	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
C1I64_RS15845	COG3590	peptidase
C1I64_RS15850	COG0702	epimerase
C1I64_RS15855	COG1733	regulation of RNA biosynthetic process
C1I64_RS15870	COG2197	response regulator
C1I64_RS15890	COG0025	NhaP-type Na H and K H
C1I64_RS15895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1I64_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS15925	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C1I64_RS15970	COG0738	Major facilitator superfamily
C1I64_RS15980	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
C1I64_RS16015	COG0488	(ABC) transporter
C1I64_RS16020	COG4941	Belongs to the sigma-70 factor family
C1I64_RS16030	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1I64_RS16035	COG1854	S-ribosylhomocysteine lyase activity
C1I64_RS16075	COG4213	ABC transporter substrate-binding protein
C1I64_RS16080	COG1129	ABC transporter
C1I64_RS16085	COG4214	carbohydrate transport
C1I64_RS16115	COG1716	ATPase activity
C1I64_RS16120	COG1716	ATPase activity
C1I64_RS16135	COG0768	penicillin binding
C1I64_RS16140	COG0515	serine threonine protein kinase
C1I64_RS16145	COG0515	serine threonine protein kinase
C1I64_RS16160	COG3764	Sortase (surface protein transpeptidase)
C1I64_RS16170	COG2890	protein-(glutamine-N5) methyltransferase activity
C1I64_RS16175	COG0705	Rhomboid family
C1I64_RS16220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1I64_RS16225	COG0187	DNA topoisomerase II activity
C1I64_RS16230	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
C1I64_RS16235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C1I64_RS16240	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C1I64_RS16245	COG0592	DNA-directed DNA polymerase activity
C1I64_RS16250	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1I64_RS16255	COG0230	Belongs to the bacterial ribosomal protein bL34 family
C1I64_RS16260	COG0594	ribonuclease P activity
C1I64_RS16265	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C1I64_RS16270	COG0706	membrane insertase activity
C1I64_RS16280	COG0357	Ribosomal RNA small subunit methyltransferase G
C1I64_RS16285	COG1192	Involved in chromosome partitioning
C1I64_RS16295	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1I64_RS16300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1I64_RS16305	COG3118	belongs to the thioredoxin family
C1I64_RS16310	COG0492	ferredoxin-NADP+ reductase activity
C1I64_RS16320	COG0728	peptidoglycan biosynthetic process
C1I64_RS16330	COG0617	tRNA 3'-terminal CCA addition
C1I64_RS16370	COG0360	Binds together with S18 to 16S ribosomal RNA
C1I64_RS16380	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C1I64_RS16385	COG0359	binds to the 23S rRNA
C1I64_RS16390	COG0305	Participates in initiation and elongation during chromosome replication
C1I64_RS16395	COG2501	S4 domain
C1I64_RS16410	COG1609	Transcriptional regulator
C1I64_RS16420	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
C1I64_RS16425	COG1122	ATPase activity
C1I64_RS16435	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C1I64_RS16440	COG0402	S-adenosylhomocysteine deaminase activity
C1I64_RS16460	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS16475	COG1609	Transcriptional regulator
C1I64_RS16510	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS16520	COG2272	Belongs to the type-B carboxylesterase lipase family
C1I64_RS16545	COG1175	transmembrane transport
C1I64_RS16550	COG0395	ABC-type sugar transport system, permease component
C1I64_RS16565	COG1132	(ABC) transporter
C1I64_RS16575	COG4124	Belongs to the glycosyl hydrolase 26 family
C1I64_RS16585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1I64_RS16595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1I64_RS16600	COG1464	Belongs to the NlpA lipoprotein family
C1I64_RS16605	COG2011	ABC-type metal ion transport system permease component
C1I64_RS16620	COG2226	methyltransferase
C1I64_RS16650	COG0596	Alpha beta hydrolase
C1I64_RS16655	COG0488	(ABC) transporter
C1I64_RS16670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1I64_RS16675	COG2249	NAD(P)H dehydrogenase (quinone) activity
C1I64_RS16685	COG1733	regulation of RNA biosynthetic process
C1I64_RS16695	COG0640	Transcriptional regulator
C1I64_RS16715	COG1609	Transcriptional regulator
C1I64_RS16720	COG0395	ABC-type sugar transport system, permease component
C1I64_RS16725	COG1175	transmembrane transport
C1I64_RS16745	COG1653	transport
C1I64_RS16795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1I64_RS16800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1I64_RS16805	COG1414	Transcriptional regulator
C1I64_RS16810	COG0667	Aldo Keto reductase
C1I64_RS16820	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1I64_RS16825	COG0395	ABC-type sugar transport system, permease component
C1I64_RS16830	COG1175	transmembrane transport
C1I64_RS16840	COG1609	Transcriptional regulator
C1I64_RS16925	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS16945	COG1280	lysine exporter protein (LysE YggA)
C1I64_RS16975	COG0596	Alpha beta hydrolase
C1I64_RS17005	COG0477	Major facilitator Superfamily
C1I64_RS17035	COG2390	Transcriptional regulator
C1I64_RS17040	COG1879	ABC-type sugar transport system periplasmic component
C1I64_RS17045	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS17050	COG1129	ABC transporter
C1I64_RS17060	COG1063	alcohol dehydrogenase
C1I64_RS17065	COG2376	Dihydroxyacetone kinase
C1I64_RS17070	COG0698	ribose 5-phosphate isomerase
C1I64_RS17075	COG1070	Carbohydrate kinase
C1I64_RS17100	COG0154	amidase activity
C1I64_RS17120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1I64_RS17135	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
C1I64_RS17190	COG1175	transmembrane transport
C1I64_RS17200	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
C1I64_RS17235	COG0395	ABC-type sugar transport system, permease component
C1I64_RS17245	COG1802	Transcriptional regulator
C1I64_RS17270	COG1335	isochorismatase
C1I64_RS17290	COG0444	Belongs to the ABC transporter superfamily
C1I64_RS17340	COG3665	Urea carboxylase-associated protein
C1I64_RS17360	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
C1I64_RS17415	COG2423	ornithine cyclodeaminase activity
C1I64_RS17425	COG2814	Major facilitator Superfamily
C1I64_RS17430	COG1302	Protein conserved in bacteria
C1I64_RS17510	COG0500	methyltransferase
C1I64_RS17550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1I64_RS17565	COG0739	heme binding
C1I64_RS17565	COG0741	lytic transglycosylase activity
C1I64_RS17565	COG1196	nuclear chromosome segregation
C1I64_RS17585	COG2154	pterin-4-alpha-carbinolamine dehydratase
C1I64_RS17615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1I64_RS17625	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1I64_RS17635	COG1609	Transcriptional regulator
C1I64_RS17645	COG1175	transmembrane transport
C1I64_RS17650	COG0395	ABC-type sugar transport system, permease component
C1I64_RS17660	COG2318	DinB family
C1I64_RS17725	COG0395	ABC-type sugar transport system, permease component
C1I64_RS17730	COG1175	transmembrane transport
C1I64_RS17735	COG1609	Transcriptional regulator
C1I64_RS17740	COG2354	Protein conserved in bacteria
C1I64_RS17750	COG1846	Transcriptional regulator
C1I64_RS17860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1I64_RS17885	COG0154	amidase activity
C1I64_RS17890	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS17925	COG0701	Predicted permease
C1I64_RS17950	COG2814	Major facilitator Superfamily
C1I64_RS17980	COG0789	Transcriptional regulator
C1I64_RS17985	COG0659	secondary active sulfate transmembrane transporter activity
C1I64_RS18000	COG0531	amino acid
C1I64_RS18010	COG1764	response to oxidative stress
C1I64_RS18020	COG3177	Filamentation induced by cAMP protein fic
C1I64_RS18025	COG3458	cephalosporin-C deacetylase activity
C1I64_RS18055	COG3507	Belongs to the glycosyl hydrolase 43 family
C1I64_RS18105	COG1609	Transcriptional regulator
C1I64_RS18160	COG4555	ABC transporter
C1I64_RS18180	COG3250	beta-galactosidase activity
C1I64_RS18200	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C1I64_RS18225	COG1609	Transcriptional regulator
C1I64_RS18235	COG1175	transmembrane transport
C1I64_RS18240	COG0395	ABC-type sugar transport system, permease component
C1I64_RS18250	COG0673	inositol 2-dehydrogenase activity
C1I64_RS18300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1I64_RS18305	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C1I64_RS18325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1I64_RS18340	COG2011	ABC-type metal ion transport system permease component
C1I64_RS18345	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C1I64_RS18365	COG0673	inositol 2-dehydrogenase activity
C1I64_RS18370	COG1129	ABC transporter
C1I64_RS18375	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1I64_RS18380	COG1879	ABC-type sugar transport system periplasmic component
C1I64_RS18415	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1I64_RS18450	COG1064	alcohol dehydrogenase
C1I64_RS18455	COG1309	transcriptional regulator
C1I64_RS18530	COG0402	S-adenosylhomocysteine deaminase activity
C1I64_RS18615	COG2244	polysaccharide biosynthetic process
C1I64_RS18630	COG0438	transferase activity, transferring glycosyl groups
C1I64_RS18675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1I64_RS18690	COG1950	PFAM Membrane protein of
C1I64_RS18695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1I64_RS18705	COG0022	dehydrogenase e1 component
C1I64_RS18710	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1I64_RS18715	COG2066	Belongs to the glutaminase family
C1I64_RS18720	COG3226	Transcriptional regulator
C1I64_RS18725	COG0110	maltose O-acetyltransferase activity
C1I64_RS18730	COG0738	Major facilitator superfamily
C1I64_RS18740	COG3534	alpha-L-arabinofuranosidase
C1I64_RS18750	COG0110	maltose O-acetyltransferase activity
C1I64_RS18765	COG0803	Belongs to the bacterial solute-binding protein 9 family
C1I64_RS18770	COG1121	(ABC) transporter
C1I64_RS18775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1I64_RS18780	COG0735	belongs to the Fur family
C1I64_RS18810	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C1I64_RS18815	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1I64_RS18840	COG0477	Major facilitator Superfamily
C1I64_RS18850	COG2079	MmgE PrpD family protein
C1I64_RS18855	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS18860	COG0583	DNA-binding transcription factor activity
C1I64_RS18890	COG3408	Glycogen debranching enzyme
C1I64_RS18900	COG5564	TIM-barrel signal transduction protein
C1I64_RS18925	COG0395	ABC-type sugar transport system, permease component
C1I64_RS18935	COG1653	transport
C1I64_RS18940	COG1028	Short-chain dehydrogenase reductase Sdr
C1I64_RS18950	COG1609	Transcriptional regulator
C1I64_RS18980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1I64_RS19005	COG2361	Protein of unknown function DUF86
C1I64_RS19020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1I64_RS19045	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C1I64_RS19050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
C1I64_RS19055	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C1I64_RS19070	COG1357	PFAM Pentapeptide repeats (8 copies)
C1I64_RS19120	COG0028	Belongs to the TPP enzyme family
C1I64_RS19130	COG2814	Major facilitator Superfamily
C1I64_RS19145	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS19185	COG0477	Major facilitator Superfamily
C1I64_RS19210	COG1278	Cold shock
C1I64_RS19225	COG2197	response regulator
C1I64_RS19260	COG2184	nucleotidyltransferase activity
C1I64_RS19285	COG0583	DNA-binding transcription factor activity
C1I64_RS19330	COG2205	protein histidine kinase activity
C1I64_RS19335	COG0745	RESPONSE REGULATOR receiver
C1I64_RS19355	COG1120	ATPase activity
C1I64_RS19375	COG3046	protein related to deoxyribodipyrimidine photolyase
C1I64_RS19395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1I64_RS19405	COG0025	NhaP-type Na H and K H
C1I64_RS19420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
C1I64_RS19420	COG2308	Evidence 4 Homologs of previously reported genes of
C1I64_RS19425	COG0367	asparagine synthase
C1I64_RS19445	COG0776	regulation of translation
C1I64_RS19450	COG3336	cytochrome c oxidase
C1I64_RS19455	COG1131	(ABC) transporter
C1I64_RS19465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1I64_RS19485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C1I64_RS19505	COG1609	Transcriptional regulator
C1I64_RS19520	COG0717	Belongs to the dCTP deaminase family
C1I64_RS19525	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
C1I64_RS19530	COG0142	geranyltranstransferase activity
C1I64_RS19560	COG0443	Heat shock 70 kDa protein
C1I64_RS19565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1I64_RS19570	COG0484	heat shock protein binding
C1I64_RS19575	COG0789	Transcriptional regulator
C1I64_RS19600	COG0423	glycine-tRNA ligase activity
C1I64_RS19605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1I64_RS19610	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C1I64_RS19615	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C1I64_RS19620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C1I64_RS19640	COG3253	May function as heme-dependent peroxidase
C1I64_RS19645	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C1I64_RS19650	COG0181	hydroxymethylbilane synthase activity
C1I64_RS19665	COG0113	porphobilinogen synthase activity
C1I64_RS19670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C1I64_RS19675	COG0477	Major facilitator Superfamily
C1I64_RS19680	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C1I64_RS19690	COG0604	alcohol dehydrogenase
C1I64_RS19695	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C1I64_RS19700	COG1054	Belongs to the UPF0176 family
C1I64_RS19705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C1I64_RS19740	COG1012	belongs to the aldehyde dehydrogenase family
C1I64_RS19760	COG1136	(ABC) transporter
C1I64_RS19805	COG1309	transcriptional regulator
C1I64_RS19835	COG4565	transcriptional regulatory protein
C1I64_RS19840	COG3290	protein histidine kinase activity
C1I64_RS19845	COG1301	dicarboxylic acid transport
C1I64_RS19850	COG2364	Membrane
C1I64_RS19855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs