locus-tag	class	description
AYW78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AYW78_RS00010	COG0592	DNA-directed DNA polymerase activity
AYW78_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
AYW78_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
AYW78_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
AYW78_RS00030	COG0187	DNA topoisomerase II activity
AYW78_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AYW78_RS00075	COG3764	Sortase (surface protein transpeptidase)
AYW78_RS00100	COG0515	serine threonine protein kinase
AYW78_RS00120	COG1716	ATPase activity
AYW78_RS00140	COG1854	S-ribosylhomocysteine lyase activity
AYW78_RS00145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AYW78_RS00155	COG0488	(ABC) transporter
AYW78_RS00180	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
AYW78_RS00185	COG0738	Major facilitator superfamily
AYW78_RS00245	COG5001	Diguanylate cyclase
AYW78_RS00280	COG1131	(ABC) transporter
AYW78_RS00285	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS00300	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
AYW78_RS00350	COG0702	epimerase
AYW78_RS00355	COG3590	peptidase
AYW78_RS00375	COG0542	response to heat
AYW78_RS00380	COG2003	Belongs to the UPF0758 family
AYW78_RS00385	COG1063	alcohol dehydrogenase
AYW78_RS00420	COG0445	tRNA wobble uridine modification
AYW78_RS00430	COG2192	nodulation
AYW78_RS00450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AYW78_RS00485	COG2197	response regulator
AYW78_RS00490	COG4585	Histidine kinase
AYW78_RS00520	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AYW78_RS00545	COG2315	Protein conserved in bacteria
AYW78_RS00560	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
AYW78_RS00565	COG1518	maintenance of DNA repeat elements
AYW78_RS00600	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
AYW78_RS00605	COG1136	(ABC) transporter
AYW78_RS00605	COG0577	efflux transmembrane transporter activity
AYW78_RS00640	COG0473	3-isopropylmalate dehydrogenase activity
AYW78_RS00640	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYW78_RS00645	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
AYW78_RS00645	COG0473	3-isopropylmalate dehydrogenase activity
AYW78_RS00655	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYW78_RS00670	COG3546	catalase activity
AYW78_RS00685	COG1764	response to oxidative stress
AYW78_RS00690	COG0287	Prephenate dehydrogenase
AYW78_RS00690	COG1605	Chorismate mutase
AYW78_RS00705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYW78_RS00730	COG0047	phosphoribosylformylglycinamidine synthase activity
AYW78_RS00735	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AYW78_RS00770	COG0647	UMP catabolic process
AYW78_RS00780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AYW78_RS00800	COG3424	synthase
AYW78_RS00805	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS00820	COG0151	Belongs to the GarS family
AYW78_RS00830	COG0737	Belongs to the 5'-nucleotidase family
AYW78_RS00845	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AYW78_RS00860	COG2267	carboxylic ester hydrolase activity
AYW78_RS00870	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
AYW78_RS00875	COG0531	amino acid
AYW78_RS00880	COG2130	NADP-dependent
AYW78_RS00980	COG0747	negative chemotaxis
AYW78_RS00990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYW78_RS01050	COG0514	ATP-dependent DNA helicase (RecQ)
AYW78_RS01075	COG2357	RelA SpoT domain protein
AYW78_RS01115	COG3883	PFAM NLP P60 protein
AYW78_RS01115	COG0791	NLP P60 protein
AYW78_RS01120	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AYW78_RS01125	COG0037	tRNA processing
AYW78_RS01135	COG1597	lipid kinase activity
AYW78_RS01145	COG1511	domain protein
AYW78_RS01145	COG1511	domain protein
AYW78_RS01150	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AYW78_RS01155	COG0302	gtp cyclohydrolase
AYW78_RS01165	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
AYW78_RS01170	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AYW78_RS01195	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AYW78_RS01200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AYW78_RS01210	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
AYW78_RS01220	COG1252	NADH dehydrogenase
AYW78_RS01240	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AYW78_RS01250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AYW78_RS01285	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYW78_RS01295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AYW78_RS01355	COG3655	Transcriptional regulator
AYW78_RS01365	COG2233	PERMEase
AYW78_RS01415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AYW78_RS01420	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYW78_RS01425	COG0318	PFAM AMP-dependent synthetase and ligase
AYW78_RS01430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AYW78_RS01445	COG1695	Transcriptional regulator
AYW78_RS01460	COG0297	glycogen (starch) synthase activity
AYW78_RS01465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AYW78_RS01470	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYW78_RS01475	COG0415	Belongs to the DNA photolyase family
AYW78_RS01490	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AYW78_RS01500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AYW78_RS01505	COG0640	Transcriptional regulator
AYW78_RS01530	COG1136	(ABC) transporter
AYW78_RS01530	COG0577	efflux transmembrane transporter activity
AYW78_RS01545	COG2808	Putative FMN-binding domain
AYW78_RS01565	COG1247	-acetyltransferase
AYW78_RS01585	COG1136	(ABC) transporter
AYW78_RS01585	COG0577	efflux transmembrane transporter activity
AYW78_RS01595	COG4585	Histidine kinase
AYW78_RS01610	COG0017	Asparaginyl-tRNA synthetase
AYW78_RS01615	COG0406	alpha-ribazole phosphatase activity
AYW78_RS01625	COG0785	Cytochrome C biogenesis protein
AYW78_RS01635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AYW78_RS01640	COG4948	Mandelate Racemase Muconate Lactonizing
AYW78_RS01645	COG0783	Belongs to the Dps family
AYW78_RS01675	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
AYW78_RS01685	COG2226	methyltransferase
AYW78_RS01690	COG0142	geranyltranstransferase activity
AYW78_RS01710	COG0494	nUDIX hydrolase
AYW78_RS01715	COG1666	GTP binding
AYW78_RS01735	COG0366	Alpha amylase catalytic
AYW78_RS01740	COG1320	monovalent cation:proton antiporter activity
AYW78_RS01755	COG0651	ATP synthesis coupled electron transport
AYW78_RS01760	COG1006	Multisubunit Na H antiporter MnhC subunit
AYW78_RS01765	COG2111	Na H antiporter
AYW78_RS01765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AYW78_RS01770	COG0823	Involved in the tonB-independent uptake of proteins
AYW78_RS01800	COG2030	dehydratase
AYW78_RS01810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
AYW78_RS01815	COG0436	Aminotransferase
AYW78_RS01825	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AYW78_RS01830	COG0250	Participates in transcription elongation, termination and antitermination
AYW78_RS01835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AYW78_RS01840	COG0081	regulation of translation
AYW78_RS01860	COG1309	transcriptional regulator
AYW78_RS01865	COG0531	amino acid
AYW78_RS01870	COG0745	RESPONSE REGULATOR receiver
AYW78_RS01875	COG2205	protein histidine kinase activity
AYW78_RS01880	COG0673	inositol 2-dehydrogenase activity
AYW78_RS01890	COG0656	L-ascorbic acid biosynthetic process
AYW78_RS01895	COG2261	transglycosylase associated protein
AYW78_RS01925	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
AYW78_RS01930	COG0222	ribosome binding
AYW78_RS01940	COG1653	transport
AYW78_RS01945	COG1175	transmembrane transport
AYW78_RS01950	COG0395	ABC-type sugar transport system, permease component
AYW78_RS01985	COG1780	Probably involved in ribonucleotide reductase function
AYW78_RS01990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYW78_RS01995	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AYW78_RS02000	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYW78_RS02005	COG2267	carboxylic ester hydrolase activity
AYW78_RS02020	COG0517	IMP dehydrogenase activity
AYW78_RS02020	COG4175	Glycine betaine
AYW78_RS02030	COG1070	Carbohydrate kinase
AYW78_RS02035	COG2115	Belongs to the xylose isomerase family
AYW78_RS02065	COG1131	(ABC) transporter
AYW78_RS02100	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
AYW78_RS02110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AYW78_RS02125	COG0579	oxidoreductase
AYW78_RS02135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AYW78_RS02145	COG0489	protein tyrosine kinase activity
AYW78_RS02145	COG3206	protein involved in exopolysaccharide biosynthesis
AYW78_RS02150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYW78_RS02155	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AYW78_RS02185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYW78_RS02220	COG1754	DNA topoisomerase type I activity
AYW78_RS02220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AYW78_RS02225	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AYW78_RS02230	COG0470	DNA polymerase III
AYW78_RS02255	COG0582	viral genome integration into host DNA
AYW78_RS02350	COG1335	isochorismatase
AYW78_RS02370	COG1132	(ABC) transporter
AYW78_RS02385	COG0477	Major facilitator Superfamily
AYW78_RS02390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AYW78_RS02395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYW78_RS02395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AYW78_RS02450	COG0328	RNA-DNA hybrid ribonuclease activity
AYW78_RS02460	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
AYW78_RS02480	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AYW78_RS02485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
AYW78_RS02490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AYW78_RS02495	COG0180	Tryptophanyl-tRNA synthetase
AYW78_RS02520	COG1349	DNA-binding transcription factor activity
AYW78_RS02530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AYW78_RS02545	COG2009	succinate dehydrogenase
AYW78_RS02560	COG3845	ABC transporter
AYW78_RS02565	COG4603	Belongs to the binding-protein-dependent transport system permease family
AYW78_RS02570	COG1079	Belongs to the binding-protein-dependent transport system permease family
AYW78_RS02590	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYW78_RS02600	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYW78_RS02625	COG4770	biotin carboxylase activity
AYW78_RS02630	COG0424	maF-like protein
AYW78_RS02635	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AYW78_RS02645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYW78_RS02650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AYW78_RS02655	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AYW78_RS02655	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AYW78_RS02675	COG1316	TRANSCRIPTIONal
AYW78_RS02705	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
AYW78_RS02725	COG1216	Glycosyl transferase, family 2
AYW78_RS02740	COG0438	transferase activity, transferring glycosyl groups
AYW78_RS02790	COG1960	acyl-CoA dehydrogenase activity
AYW78_RS02845	COG0714	Associated with various cellular activities
AYW78_RS02865	COG0745	RESPONSE REGULATOR receiver
AYW78_RS02870	COG5002	protein histidine kinase activity
AYW78_RS02880	COG1040	competence protein
AYW78_RS02885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
AYW78_RS02890	COG0653	protein targeting
AYW78_RS02915	COG0515	serine threonine protein kinase
AYW78_RS02975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
AYW78_RS02980	COG0433	COG0433 Predicted ATPase
AYW78_RS02980	COG1674	ftsk spoiiie
AYW78_RS03045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AYW78_RS03050	COG1595	DNA-templated transcription, initiation
AYW78_RS03065	COG1653	transport
AYW78_RS03070	COG1175	transmembrane transport
AYW78_RS03075	COG0395	ABC-type sugar transport system, permease component
AYW78_RS03085	COG1940	carbohydrate kinase activity
AYW78_RS03090	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYW78_RS03090	COG0567	Dehydrogenase, E1 component
AYW78_RS03140	COG1063	alcohol dehydrogenase
AYW78_RS03160	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
AYW78_RS03180	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
AYW78_RS03190	COG1704	LemA family
AYW78_RS03195	COG0501	Belongs to the peptidase M48B family
AYW78_RS03225	COG3842	ATPase activity
AYW78_RS03235	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AYW78_RS03240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AYW78_RS03250	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYW78_RS03265	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYW78_RS03270	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
AYW78_RS03280	COG0114	fumarate hydratase activity
AYW78_RS03295	COG1722	exodeoxyribonuclease VII activity
AYW78_RS03300	COG1570	exodeoxyribonuclease VII activity
AYW78_RS03305	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AYW78_RS03315	COG0191	fructose-bisphosphate aldolase activity
AYW78_RS03325	COG1322	Protein conserved in bacteria
AYW78_RS03330	COG0012	GTP binding
AYW78_RS03350	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS03360	COG2326	polyphosphate kinase activity
AYW78_RS03380	COG2814	Major facilitator Superfamily
AYW78_RS03395	COG0404	The glycine cleavage system catalyzes the degradation of glycine
AYW78_RS03400	COG0509	glycine decarboxylation via glycine cleavage system
AYW78_RS03405	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYW78_RS03405	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
AYW78_RS03420	COG0601	transmembrane transport
AYW78_RS03425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYW78_RS03435	COG1217	gtp-binding protein TYPA
AYW78_RS03445	COG2837	iron assimilation
AYW78_RS03455	COG0672	)-iron permease
AYW78_RS03460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
AYW78_RS03485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYW78_RS03505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AYW78_RS03520	COG2239	Acts as a magnesium transporter
AYW78_RS03530	COG2205	protein histidine kinase activity
AYW78_RS03535	COG0745	RESPONSE REGULATOR receiver
AYW78_RS03555	COG0018	arginyl-trna synthetase
AYW78_RS03560	COG0019	diaminopimelate decarboxylase activity
AYW78_RS03565	COG0460	homoserine dehydrogenase
AYW78_RS03570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYW78_RS03575	COG0083	homoserine kinase activity
AYW78_RS03585	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AYW78_RS03590	COG2890	protein-(glutamine-N5) methyltransferase activity
AYW78_RS03595	COG1088	dTDP-glucose 4,6-dehydratase activity
AYW78_RS03625	COG0438	transferase activity, transferring glycosyl groups
AYW78_RS03655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYW78_RS03665	COG0356	it plays a direct role in the translocation of protons across the membrane
AYW78_RS03670	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYW78_RS03675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AYW78_RS03680	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AYW78_RS03685	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AYW78_RS03690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AYW78_RS03695	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AYW78_RS03700	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AYW78_RS03705	COG3022	response to hydroperoxide
AYW78_RS03710	COG2818	Glycosylase
AYW78_RS03715	COG2169	Transcriptional regulator
AYW78_RS03715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AYW78_RS03720	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
AYW78_RS03750	COG0318	PFAM AMP-dependent synthetase and ligase
AYW78_RS03750	COG0204	Acyl-transferase
AYW78_RS03755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
AYW78_RS03760	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYW78_RS03765	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AYW78_RS03770	COG0750	zinc metalloprotease
AYW78_RS03775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AYW78_RS03780	COG0442	prolyl-tRNA aminoacylation
AYW78_RS03785	COG0195	Participates in both transcription termination and antitermination
AYW78_RS03795	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AYW78_RS03800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AYW78_RS03810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
AYW78_RS03815	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
AYW78_RS03830	COG0196	riboflavin kinase activity
AYW78_RS03835	COG0702	epimerase
AYW78_RS03860	COG0583	DNA-binding transcription factor activity
AYW78_RS03875	COG1937	Protein conserved in bacteria
AYW78_RS03885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
AYW78_RS03890	COG0352	thiamine-phosphate diphosphorylase activity
AYW78_RS03890	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AYW78_RS03890	COG0351	phosphomethylpyrimidine kinase
AYW78_RS03895	COG0352	thiamine-phosphate diphosphorylase activity
AYW78_RS03900	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
AYW78_RS03905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYW78_RS03905	COG0723	plastoquinol--plastocyanin reductase activity
AYW78_RS03920	COG5607	PFAM CHAD domain containing protein
AYW78_RS03920	COG3025	triphosphatase activity
AYW78_RS03935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYW78_RS03995	COG0631	protein serine/threonine phosphatase activity
AYW78_RS04000	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AYW78_RS04005	COG0066	3-isopropylmalate dehydratase activity
AYW78_RS04010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AYW78_RS04020	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AYW78_RS04035	COG0742	ribosomal rna small subunit methyltransferase
AYW78_RS04040	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AYW78_RS04045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AYW78_RS04050	COG0778	Nitroreductase
AYW78_RS04050	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AYW78_RS04055	COG1920	GTP binding
AYW78_RS04060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
AYW78_RS04065	COG2353	YceI-like domain
AYW78_RS04085	COG1174	glycine betaine transport
AYW78_RS04090	COG1174	glycine betaine transport
AYW78_RS04140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYW78_RS04145	COG0671	phosphoesterase, PA-phosphatase related
AYW78_RS04160	COG1131	(ABC) transporter
AYW78_RS04180	COG0512	Glutamine amidotransferase of anthranilate synthase
AYW78_RS04180	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AYW78_RS04185	COG0495	leucyl-tRNA aminoacylation
AYW78_RS04200	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AYW78_RS04225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYW78_RS04245	COG2022	thiamine diphosphate biosynthetic process
AYW78_RS04245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
AYW78_RS04250	COG2890	protein-(glutamine-N5) methyltransferase activity
AYW78_RS04255	COG0438	transferase activity, transferring glycosyl groups
AYW78_RS04270	COG1555	photosystem II stabilization
AYW78_RS04270	COG1596	polysaccharide export
AYW78_RS04285	COG0268	Binds directly to 16S ribosomal RNA
AYW78_RS04295	COG0481	GTPase activity
AYW78_RS04310	COG2807	transmembrane transport
AYW78_RS04315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AYW78_RS04325	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
AYW78_RS04330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
AYW78_RS04335	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYW78_RS04340	COG0217	transcriptional regulatory protein
AYW78_RS04345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AYW78_RS04350	COG0632	four-way junction helicase activity
AYW78_RS04355	COG2255	four-way junction helicase activity
AYW78_RS04365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYW78_RS04370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AYW78_RS04380	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AYW78_RS04390	COG1196	nuclear chromosome segregation
AYW78_RS04395	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AYW78_RS04405	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AYW78_RS04410	COG4152	abc transporter atp-binding protein
AYW78_RS04430	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AYW78_RS04435	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AYW78_RS04445	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AYW78_RS04450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AYW78_RS04460	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
AYW78_RS04565	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AYW78_RS04570	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AYW78_RS04575	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AYW78_RS04580	COG0540	Belongs to the ATCase OTCase family
AYW78_RS04585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYW78_RS04595	COG0505	Belongs to the CarA family
AYW78_RS04600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYW78_RS04605	COG0284	orotidine-5'-phosphate decarboxylase activity
AYW78_RS04610	COG0194	GDP metabolic process
AYW78_RS04615	COG1758	RNA polymerase activity
AYW78_RS04625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AYW78_RS04635	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AYW78_RS04645	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AYW78_RS04650	COG0140	phosphoribosyl-ATP diphosphatase activity
AYW78_RS04655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AYW78_RS04660	COG0107	imidazoleglycerol-phosphate synthase activity
AYW78_RS04665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AYW78_RS04680	COG0134	indole-3-glycerol-phosphate synthase activity
AYW78_RS04685	COG0133	tryptophan synthase activity
AYW78_RS04690	COG0159	tryptophan synthase activity
AYW78_RS04695	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
AYW78_RS04700	COG0067	glutamate synthase
AYW78_RS04700	COG0069	glutamate synthase activity
AYW78_RS04700	COG0070	glutamate synthase
AYW78_RS04750	COG0563	adenylate kinase activity
AYW78_RS04775	COG2197	response regulator
AYW78_RS04780	COG4585	Histidine kinase
AYW78_RS04805	COG0259	pyridoxamine-phosphate oxidase activity
AYW78_RS04815	COG2050	protein possibly involved in aromatic compounds catabolism
AYW78_RS04830	COG0539	negative regulation of cytoplasmic translation
AYW78_RS04835	COG0237	dephospho-CoA kinase activity
AYW78_RS04850	COG0322	excinuclease ABC activity
AYW78_RS04855	COG1660	Displays ATPase and GTPase activities
AYW78_RS04860	COG1481	regulation of sporulation
AYW78_RS04875	COG0126	phosphoglycerate kinase activity
AYW78_RS04880	COG0149	triose-phosphate isomerase activity
AYW78_RS04885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AYW78_RS04895	COG0363	glucosamine-6-phosphate deaminase activity
AYW78_RS04910	COG0166	Belongs to the GPI family
AYW78_RS04915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AYW78_RS04925	COG0109	protoheme IX farnesyltransferase activity
AYW78_RS04930	COG1612	heme a metabolic process
AYW78_RS04950	COG0396	ATPase activity
AYW78_RS04955	COG2151	metal-sulfur cluster biosynthetic enzyme
AYW78_RS04965	COG0750	zinc metalloprotease
AYW78_RS05010	COG1131	(ABC) transporter
AYW78_RS05020	COG4585	Histidine kinase
AYW78_RS05030	COG1268	BioY protein
AYW78_RS05035	COG0488	(ABC) transporter
AYW78_RS05060	COG0560	Phosphoserine phosphatase
AYW78_RS05065	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AYW78_RS05070	COG0297	glycogen (starch) synthase activity
AYW78_RS05075	COG1119	ATPase activity
AYW78_RS05080	COG0254	rRNA binding
AYW78_RS05100	COG0406	alpha-ribazole phosphatase activity
AYW78_RS05120	COG2755	lipolytic protein G-D-S-L family
AYW78_RS05150	COG0587	DNA-directed DNA polymerase activity
AYW78_RS05165	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
AYW78_RS05180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYW78_RS05185	COG1968	undecaprenyl-diphosphatase activity
AYW78_RS05190	COG0215	cysteine-tRNA ligase activity
AYW78_RS05200	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AYW78_RS05230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AYW78_RS05235	COG0805	protein transport
AYW78_RS05240	COG4581	dead DEAH box helicase
AYW78_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS05345	COG0183	Belongs to the thiolase family
AYW78_RS05350	COG1024	Enoyl-CoA hydratase
AYW78_RS05350	COG1250	3-hydroxyacyl-CoA dehydrogenase
AYW78_RS05355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AYW78_RS05360	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
AYW78_RS05375	COG0756	dUTP diphosphatase activity
AYW78_RS05400	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AYW78_RS05420	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AYW78_RS05425	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AYW78_RS05435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AYW78_RS05440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYW78_RS05445	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYW78_RS05460	COG0174	glutamine synthetase
AYW78_RS05465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AYW78_RS05475	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AYW78_RS05515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AYW78_RS05525	COG0799	negative regulation of ribosome biogenesis
AYW78_RS05535	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
AYW78_RS05545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AYW78_RS05550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AYW78_RS05555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AYW78_RS05560	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AYW78_RS05565	COG1530	ribonuclease E activity
AYW78_RS05575	COG0105	UTP biosynthetic process
AYW78_RS05585	COG0285	dihydrofolate synthase activity
AYW78_RS05590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AYW78_RS05600	COG0525	valine-tRNA ligase activity
AYW78_RS05610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AYW78_RS05615	COG0740	serine-type endopeptidase activity
AYW78_RS05620	COG0740	serine-type endopeptidase activity
AYW78_RS05625	COG0544	peptidyl-prolyl cis-trans isomerase activity
AYW78_RS05640	COG0783	Belongs to the Dps family
AYW78_RS05660	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AYW78_RS05675	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AYW78_RS05685	COG0668	transmembrane transport
AYW78_RS05725	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYW78_RS05760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYW78_RS05770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYW78_RS05770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYW78_RS05780	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYW78_RS05810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
AYW78_RS05835	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
AYW78_RS05855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
AYW78_RS05860	COG1122	ATPase activity
AYW78_RS05865	COG4721	ABC-type cobalt transport system, permease component
AYW78_RS05885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
AYW78_RS05890	COG0318	PFAM AMP-dependent synthetase and ligase
AYW78_RS05900	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYW78_RS05905	COG0154	amidase activity
AYW78_RS05910	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AYW78_RS05915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AYW78_RS05920	COG0482	sulfurtransferase activity
AYW78_RS05930	COG0366	Alpha amylase catalytic
AYW78_RS05935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
AYW78_RS05985	COG0233	cytoplasmic translational termination
AYW78_RS05990	COG0528	UMP kinase activity
AYW78_RS05995	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AYW78_RS06000	COG0052	Belongs to the universal ribosomal protein uS2 family
AYW78_RS06005	COG0477	Major facilitator Superfamily
AYW78_RS06015	COG4974	Belongs to the 'phage' integrase family
AYW78_RS06040	COG0792	nuclease activity
AYW78_RS06050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AYW78_RS06055	COG0681	Belongs to the peptidase S26 family
AYW78_RS06060	COG0335	large ribosomal subunit rRNA binding
AYW78_RS06070	COG0024	Methionine aminopeptidase
AYW78_RS06075	COG0336	Belongs to the RNA methyltransferase TrmD family
AYW78_RS06080	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AYW78_RS06085	COG1837	Belongs to the UPF0109 family
AYW78_RS06090	COG0228	four-way junction DNA binding
AYW78_RS06095	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
AYW78_RS06110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AYW78_RS06115	COG0321	lipoyl(octanoyl) transferase activity
AYW78_RS06120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
AYW78_RS06125	COG0552	protein localization to endoplasmic reticulum
AYW78_RS06130	COG1196	nuclear chromosome segregation
AYW78_RS06155	COG0315	cyclic pyranopterin monophosphate synthase activity
AYW78_RS06160	COG0521	Mo-molybdopterin cofactor biosynthetic process
AYW78_RS06175	COG1529	Aldehyde oxidase and xanthine dehydrogenase
AYW78_RS06175	COG2080	2 iron, 2 sulfur cluster binding
AYW78_RS06180	COG3608	succinylglutamate desuccinylase aspartoacylase
AYW78_RS06180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
AYW78_RS06195	COG3619	membrane
AYW78_RS06205	COG0019	diaminopimelate decarboxylase activity
AYW78_RS06210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
AYW78_RS06215	COG0571	ribonuclease III activity
AYW78_RS06220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AYW78_RS06230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
AYW78_RS06255	COG1131	(ABC) transporter
AYW78_RS06280	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
AYW78_RS06295	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AYW78_RS06300	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AYW78_RS06305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AYW78_RS06330	COG0463	Glycosyl transferase, family 2
AYW78_RS06345	COG3409	Peptidoglycan-binding domain 1 protein
AYW78_RS06360	COG0438	transferase activity, transferring glycosyl groups
AYW78_RS06370	COG0242	peptide deformylase activity
AYW78_RS06390	COG4172	Belongs to the ABC transporter superfamily
AYW78_RS06395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AYW78_RS06400	COG0601	transmembrane transport
AYW78_RS06410	COG0358	DNA primase activity
AYW78_RS06415	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AYW78_RS06430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AYW78_RS06435	COG1381	Involved in DNA repair and RecF pathway recombination
AYW78_RS06440	COG2860	membrane
AYW78_RS06445	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYW78_RS06450	COG2197	response regulator
AYW78_RS06455	COG4585	Histidine kinase
AYW78_RS06460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AYW78_RS06470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AYW78_RS06480	COG0537	adenosine 5'-monophosphoramidase activity
AYW78_RS06490	COG0484	heat shock protein binding
AYW78_RS06495	COG1420	regulation of RNA biosynthetic process
AYW78_RS06555	COG0277	FAD linked oxidase domain protein
AYW78_RS06575	COG1461	Dihydroxyacetone kinase
AYW78_RS06580	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AYW78_RS06585	COG1845	cytochrome c oxidase, subunit III
AYW78_RS06590	COG2010	Cytochrome c
AYW78_RS06595	COG0723	plastoquinol--plastocyanin reductase activity
AYW78_RS06600	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AYW78_RS06610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
AYW78_RS06615	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
AYW78_RS06625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
AYW78_RS06635	COG0167	dihydroorotate dehydrogenase activity
AYW78_RS06640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AYW78_RS06645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AYW78_RS06660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AYW78_RS06665	COG3599	regulation of cell shape
AYW78_RS06675	COG1799	cell septum assembly
AYW78_RS06685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AYW78_RS06695	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AYW78_RS06700	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AYW78_RS06710	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AYW78_RS06715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AYW78_RS06725	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AYW78_RS06740	COG0275	rRNA processing
AYW78_RS06745	COG2001	Belongs to the MraZ family
AYW78_RS06755	COG0142	geranyltranstransferase activity
AYW78_RS06765	COG0515	serine threonine protein kinase
AYW78_RS06765	COG2815	serine threonine protein kinase
AYW78_RS06770	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AYW78_RS06775	COG0204	Acyl-transferase
AYW78_RS06775	COG0318	PFAM AMP-dependent synthetase and ligase
AYW78_RS06780	COG1940	carbohydrate kinase activity
AYW78_RS06800	COG1192	Involved in chromosome partitioning
AYW78_RS06815	COG1716	ATPase activity
AYW78_RS06820	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AYW78_RS06825	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
AYW78_RS06855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYW78_RS06860	COG0484	heat shock protein binding
AYW78_RS06870	COG1522	sequence-specific DNA binding
AYW78_RS06875	COG0686	Belongs to the AlaDH PNT family
AYW78_RS06880	COG3265	gluconokinase activity
AYW78_RS06885	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AYW78_RS06890	COG1793	dna ligase
AYW78_RS06890	COG3285	dna ligase
AYW78_RS06900	COG0137	argininosuccinate synthase activity
AYW78_RS06915	COG2130	NADP-dependent
AYW78_RS06930	COG0531	amino acid
AYW78_RS06995	COG1160	GTP binding
AYW78_RS07000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYW78_RS07045	COG1160	GTP binding
AYW78_RS07050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AYW78_RS07065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
AYW78_RS07070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
AYW78_RS07080	COG4974	Belongs to the 'phage' integrase family
AYW78_RS07085	COG0494	nUDIX hydrolase
AYW78_RS07090	COG0504	CTP synthase activity
AYW78_RS07095	COG0497	DNA recombination
AYW78_RS07100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AYW78_RS07130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AYW78_RS07135	COG2094	Belongs to the DNA glycosylase MPG family
AYW78_RS07140	COG0165	Argininosuccinate lyase
AYW78_RS07145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AYW78_RS07150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AYW78_RS07155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AYW78_RS07160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AYW78_RS07165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AYW78_RS07170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYW78_RS07170	COG0072	phenylalanine-tRNA ligase activity
AYW78_RS07175	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AYW78_RS07180	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYW78_RS07185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AYW78_RS07190	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AYW78_RS07195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AYW78_RS07210	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AYW78_RS07215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AYW78_RS07220	COG0131	Imidazoleglycerol-phosphate dehydratase
AYW78_RS07225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYW78_RS07235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AYW78_RS07250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
AYW78_RS07260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AYW78_RS07265	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AYW78_RS07270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AYW78_RS07280	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AYW78_RS07290	COG1396	sequence-specific DNA binding
AYW78_RS07295	COG1546	Belongs to the CinA family
AYW78_RS07295	COG1058	Belongs to the CinA family
AYW78_RS07305	COG1674	ftsk spoiiie
AYW78_RS07315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYW78_RS07320	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AYW78_RS07335	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AYW78_RS07340	COG0406	alpha-ribazole phosphatase activity
AYW78_RS07345	COG0612	Peptidase, M16
AYW78_RS07350	COG1185	polyribonucleotide nucleotidyltransferase activity
AYW78_RS07355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AYW78_RS07365	COG0545	Peptidyl-prolyl cis-trans isomerase
AYW78_RS07390	COG0596	Alpha beta hydrolase
AYW78_RS07460	COG3634	alkyl hydroperoxide reductase activity
AYW78_RS07465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AYW78_RS07480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AYW78_RS07485	COG0859	PFAM glycosyl transferase family 9
AYW78_RS07495	COG0438	transferase activity, transferring glycosyl groups
AYW78_RS07500	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
AYW78_RS07505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AYW78_RS07505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AYW78_RS07510	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS07530	COG0859	PFAM glycosyl transferase family 9
AYW78_RS07545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AYW78_RS07545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AYW78_RS07560	COG0179	Fumarylacetoacetate (FAA) hydrolase
AYW78_RS07565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
AYW78_RS07570	COG0473	3-isopropylmalate dehydrogenase activity
AYW78_RS07620	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AYW78_RS07635	COG0129	dihydroxy-acid dehydratase activity
AYW78_RS07665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
AYW78_RS07670	COG3387	PFAM Glycoside hydrolase 15-related
AYW78_RS07700	COG0483	inositol monophosphate 1-phosphatase activity
AYW78_RS07715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AYW78_RS07720	COG2177	Part of the ABC transporter FtsEX involved in
AYW78_RS07725	COG2884	Cell division ATP-binding protein ftsE
AYW78_RS07730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
AYW78_RS07755	COG0586	Pfam SNARE associated Golgi protein
AYW78_RS07760	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AYW78_RS07765	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AYW78_RS07770	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AYW78_RS07800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AYW78_RS07805	COG3942	CHAP domain
AYW78_RS07820	COG1615	UPF0182 protein
AYW78_RS07825	COG3480	Lon protease (S16) C-terminal proteolytic domain
AYW78_RS07855	COG0210	DNA helicase
AYW78_RS07885	COG0513	Belongs to the DEAD box helicase family
AYW78_RS07890	COG0613	PHP domain protein
AYW78_RS07895	COG0006	proline dipeptidase activity
AYW78_RS07930	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
AYW78_RS07950	COG0542	response to heat
AYW78_RS07970	COG1024	Enoyl-CoA hydratase
AYW78_RS07975	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
AYW78_RS08030	COG0148	phosphopyruvate hydratase activity
AYW78_RS08035	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
AYW78_RS08040	COG0124	histidyl-tRNA synthetase
AYW78_RS08045	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AYW78_RS08060	COG0193	aminoacyl-tRNA hydrolase activity
AYW78_RS08065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AYW78_RS08070	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
AYW78_RS08075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AYW78_RS08080	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AYW78_RS08090	COG1846	Transcriptional regulator
AYW78_RS08095	COG0488	(ABC) transporter
AYW78_RS08110	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AYW78_RS08115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
AYW78_RS08120	COG0084	hydrolase, TatD family'
AYW78_RS08125	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AYW78_RS08140	COG1690	Belongs to the RtcB family
AYW78_RS08150	COG1760	l-serine dehydratase
AYW78_RS08165	COG1643	Atp-dependent helicase
AYW78_RS08180	COG0656	L-ascorbic acid biosynthetic process
AYW78_RS08195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
AYW78_RS08265	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AYW78_RS08325	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
AYW78_RS08335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYW78_RS08340	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AYW78_RS08350	COG2072	flavoprotein involved in K transport
AYW78_RS08355	COG1846	Transcriptional regulator
AYW78_RS08415	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
AYW78_RS08435	COG0745	RESPONSE REGULATOR receiver
AYW78_RS08440	COG2205	protein histidine kinase activity
AYW78_RS08445	COG0459	protein refolding
AYW78_RS08450	COG1278	Cold shock
AYW78_RS08465	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AYW78_RS08485	COG3842	ATPase activity
AYW78_RS08495	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AYW78_RS08500	COG0215	cysteine-tRNA ligase activity
AYW78_RS08505	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AYW78_RS08505	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AYW78_RS08510	COG1329	Transcriptional regulator
AYW78_RS08520	COG0745	RESPONSE REGULATOR receiver
AYW78_RS08525	COG5002	protein histidine kinase activity
AYW78_RS08535	COG0588	phosphoglycerate mutase activity
AYW78_RS08545	COG4044	May play a role in the intracellular transport of hydrophobic ligands
AYW78_RS08560	COG0745	RESPONSE REGULATOR receiver
AYW78_RS08565	COG0454	-acetyltransferase
AYW78_RS08565	COG0456	acetyltransferase
AYW78_RS08570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AYW78_RS08575	COG0406	alpha-ribazole phosphatase activity
AYW78_RS08575	COG0494	nUDIX hydrolase
AYW78_RS08580	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AYW78_RS08590	COG0581	inorganic phosphate transmembrane transporter activity
AYW78_RS08595	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AYW78_RS08635	COG2733	membrane
AYW78_RS08645	COG1349	DNA-binding transcription factor activity
AYW78_RS08655	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
AYW78_RS08660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AYW78_RS08665	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AYW78_RS08685	COG1404	Belongs to the peptidase S8 family
AYW78_RS08705	COG0138	bifunctional purine biosynthesis protein purh
AYW78_RS08725	COG0045	succinate-CoA ligase (ADP-forming) activity
AYW78_RS08775	COG0584	glycerophosphoryl diester phosphodiesterase
AYW78_RS08785	COG0519	Catalyzes the synthesis of GMP from XMP
AYW78_RS08785	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AYW78_RS08795	COG0475	glutathione-regulated potassium exporter activity
AYW78_RS08805	COG0516	GMP reductase activity
AYW78_RS08845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AYW78_RS08855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AYW78_RS08860	COG0456	acetyltransferase
AYW78_RS08870	COG0802	atpase or kinase
AYW78_RS08875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AYW78_RS08880	COG0736	holo-[acyl-carrier-protein] synthase activity
AYW78_RS08885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AYW78_RS08890	COG1072	(Pantothenic acid kinase))
AYW78_RS08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AYW78_RS08900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AYW78_RS08905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AYW78_RS08930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYW78_RS08940	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AYW78_RS08940	COG0028	Belongs to the TPP enzyme family
AYW78_RS08955	COG0101	tRNA pseudouridine synthase activity
AYW78_RS08965	COG0203	ribosomal protein L17
AYW78_RS08970	COG0202	RNA polymerase activity
AYW78_RS08975	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AYW78_RS08980	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
AYW78_RS08985	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AYW78_RS08990	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AYW78_RS09000	COG0246	Mannitol dehydrogenase
AYW78_RS09010	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AYW78_RS09015	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AYW78_RS09020	COG0024	Methionine aminopeptidase
AYW78_RS09025	COG0563	adenylate kinase activity
AYW78_RS09035	COG0200	Binds to the 23S rRNA
AYW78_RS09040	COG1841	ribosomal large subunit assembly
AYW78_RS09045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AYW78_RS09050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AYW78_RS09055	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AYW78_RS09060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AYW78_RS09065	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AYW78_RS09070	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AYW78_RS09075	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AYW78_RS09080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AYW78_RS09085	COG0255	Belongs to the universal ribosomal protein uL29 family
AYW78_RS09090	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AYW78_RS09095	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AYW78_RS09100	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AYW78_RS09105	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AYW78_RS09110	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AYW78_RS09115	COG0089	rRNA binding
AYW78_RS09120	COG0088	Forms part of the polypeptide exit tunnel
AYW78_RS09125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AYW78_RS09130	COG0051	transcription antitermination factor activity, RNA binding
AYW78_RS09135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AYW78_RS09140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AYW78_RS09145	COG0049	tRNA binding
AYW78_RS09150	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AYW78_RS09160	COG1126	abc transporter atp-binding protein
AYW78_RS09165	COG0765	amino acid transport
AYW78_RS09170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AYW78_RS09180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AYW78_RS09185	COG0085	RNA polymerase activity
AYW78_RS09260	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS09280	COG1201	RNA secondary structure unwinding
AYW78_RS09315	COG1316	TRANSCRIPTIONal
AYW78_RS09325	COG2089	acid synthase
AYW78_RS09340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
AYW78_RS09345	COG1011	Hydrolase
AYW78_RS09360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AYW78_RS09370	COG0077	Prephenate dehydratase
AYW78_RS09430	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AYW78_RS09450	COG2851	Citrate transporter
AYW78_RS09475	COG0588	phosphoglycerate mutase activity
AYW78_RS09510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AYW78_RS09520	COG0477	Major facilitator Superfamily
AYW78_RS09530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AYW78_RS09545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AYW78_RS09565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AYW78_RS09570	COG0028	Belongs to the TPP enzyme family
AYW78_RS09570	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
AYW78_RS09585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYW78_RS09690	COG2372	response to copper ion
AYW78_RS09710	COG0513	Belongs to the DEAD box helicase family
AYW78_RS09730	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
AYW78_RS09735	COG1301	dicarboxylic acid transport
AYW78_RS09740	COG3290	protein histidine kinase activity
AYW78_RS09745	COG4565	transcriptional regulatory protein
AYW78_RS09770	COG1116	anion transmembrane transporter activity
AYW78_RS09795	COG1054	Belongs to the UPF0176 family
AYW78_RS09810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AYW78_RS09815	COG0113	porphobilinogen synthase activity
AYW78_RS09825	COG0181	hydroxymethylbilane synthase activity
AYW78_RS09830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AYW78_RS09835	COG3253	May function as heme-dependent peroxidase
AYW78_RS09855	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
AYW78_RS09860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AYW78_RS09865	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AYW78_RS09875	COG0423	glycine-tRNA ligase activity
AYW78_RS09890	COG0789	Transcriptional regulator
AYW78_RS09895	COG0484	heat shock protein binding
AYW78_RS09900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AYW78_RS09905	COG0443	Heat shock 70 kDa protein
AYW78_RS09935	COG0142	geranyltranstransferase activity
AYW78_RS09940	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
AYW78_RS09945	COG0717	Belongs to the dCTP deaminase family
AYW78_RS09965	COG0464	growth
AYW78_RS10000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AYW78_RS10010	COG1131	(ABC) transporter
AYW78_RS10015	COG3336	cytochrome c oxidase
AYW78_RS10020	COG0776	regulation of translation
AYW78_RS10060	COG3046	protein related to deoxyribodipyrimidine photolyase
AYW78_RS10095	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AYW78_RS10120	COG1278	Cold shock
AYW78_RS10170	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYW78_RS10175	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
AYW78_RS10180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AYW78_RS10185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AYW78_RS10190	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AYW78_RS10200	COG1012	belongs to the aldehyde dehydrogenase family
AYW78_RS10215	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
AYW78_RS10220	COG0252	asparaginase activity
AYW78_RS10225	COG0735	belongs to the Fur family
AYW78_RS10230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AYW78_RS10235	COG1121	(ABC) transporter
AYW78_RS10240	COG0803	Belongs to the bacterial solute-binding protein 9 family
AYW78_RS10245	COG0508	dehydrogenase complex catalyzes the overall conversion of
AYW78_RS10250	COG0022	dehydrogenase e1 component
AYW78_RS10260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AYW78_RS10270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AYW78_RS10275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AYW78_RS10315	COG1136	(ABC) transporter
AYW78_RS10315	COG0577	efflux transmembrane transporter activity
AYW78_RS10325	COG1136	(ABC) transporter
AYW78_RS10325	COG0577	efflux transmembrane transporter activity
AYW78_RS10330	COG1136	(ABC) transporter
AYW78_RS10330	COG0577	efflux transmembrane transporter activity
AYW78_RS10395	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
AYW78_RS10425	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYW78_RS10430	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AYW78_RS10460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
AYW78_RS10465	COG2264	protein methyltransferase activity
AYW78_RS10525	COG2814	Major facilitator Superfamily
AYW78_RS10540	COG1764	response to oxidative stress
AYW78_RS10575	COG1120	ATPase activity
AYW78_RS10580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AYW78_RS10595	COG2354	Protein conserved in bacteria
AYW78_RS10690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AYW78_RS10715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AYW78_RS10730	COG2610	gluconate transmembrane transporter activity
AYW78_RS10735	COG3386	PFAM SMP-30 Gluconolaconase
AYW78_RS10740	COG1414	Transcriptional regulator
AYW78_RS10745	COG1129	ABC transporter
AYW78_RS10775	COG1131	(ABC) transporter
AYW78_RS10785	COG2084	Dehydrogenase
AYW78_RS10820	COG1028	Short-chain dehydrogenase reductase Sdr
AYW78_RS10825	COG1063	alcohol dehydrogenase
AYW78_RS10845	COG0305	Participates in initiation and elongation during chromosome replication
AYW78_RS10850	COG0359	binds to the 23S rRNA
AYW78_RS10855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AYW78_RS10865	COG0360	Binds together with S18 to 16S ribosomal RNA
AYW78_RS10870	COG0617	tRNA 3'-terminal CCA addition
AYW78_RS10885	COG0492	ferredoxin-NADP+ reductase activity
AYW78_RS10890	COG3118	belongs to the thioredoxin family
AYW78_RS10895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
AYW78_RS10900	COG1181	Belongs to the D-alanine--D-alanine ligase family
AYW78_RS10910	COG1192	Involved in chromosome partitioning
AYW78_RS10915	COG0357	Ribosomal RNA small subunit methyltransferase G
AYW78_RS10925	COG0706	membrane insertase activity
AYW78_RS10930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AYW78_RS10935	COG0594	ribonuclease P activity
AYW78_RS10940	COG0230	Belongs to the bacterial ribosomal protein bL34 family