locus-tag	class	description
E0Z06_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0Z06_RS00020	COG0187	DNA topoisomerase II activity
E0Z06_RS00025	COG0752	glycyl-tRNA synthetase alpha subunit
E0Z06_RS00030	COG0751	glycine-tRNA ligase activity
E0Z06_RS00040	COG0577	efflux transmembrane transporter activity
E0Z06_RS00040	COG1136	(ABC) transporter
E0Z06_RS00070	COG3706	GGDEF domain
E0Z06_RS00085	COG0425	Belongs to the sulfur carrier protein TusA family
E0Z06_RS00090	COG0183	Belongs to the thiolase family
E0Z06_RS00095	COG1024	Enoyl-CoA hydratase
E0Z06_RS00095	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0Z06_RS00100	COG0741	lytic transglycosylase activity
E0Z06_RS00105	COG0006	proline dipeptidase activity
E0Z06_RS00110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E0Z06_RS00115	COG0569	domain protein
E0Z06_RS00120	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E0Z06_RS00120	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0Z06_RS00125	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0Z06_RS00140	COG0758	DNA mediated transformation
E0Z06_RS00145	COG2922	Belongs to the Smg family
E0Z06_RS00150	COG0551	DNA topoisomerase type I activity
E0Z06_RS00160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0Z06_RS00165	COG0009	L-threonylcarbamoyladenylate synthase
E0Z06_RS00170	COG0408	coproporphyrinogen oxidase activity
E0Z06_RS00180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E0Z06_RS00190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
E0Z06_RS00225	COG1444	tRNA N-acetyltransferase activity
E0Z06_RS00230	COG0210	DNA helicase
E0Z06_RS00235	COG1011	Hydrolase
E0Z06_RS00245	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E0Z06_RS00255	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E0Z06_RS00260	COG0019	diaminopimelate decarboxylase activity
E0Z06_RS00270	COG1965	Belongs to the frataxin family
E0Z06_RS00285	COG1587	Uroporphyrinogen-III synthase
E0Z06_RS00290	COG2959	enzyme of heme biosynthesis
E0Z06_RS00310	COG0824	Thioesterase
E0Z06_RS00365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E0Z06_RS00370	COG2200	EAL domain
E0Z06_RS00375	COG0626	cystathionine gamma-synthase activity
E0Z06_RS00405	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
E0Z06_RS00415	COG0668	transmembrane transport
E0Z06_RS00455	COG0577	efflux transmembrane transporter activity
E0Z06_RS00455	COG1136	(ABC) transporter
E0Z06_RS00460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
E0Z06_RS00470	COG1451	nucleotide metabolic process
E0Z06_RS00480	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E0Z06_RS00485	COG1252	NADH dehydrogenase
E0Z06_RS00495	COG3118	belongs to the thioredoxin family
E0Z06_RS00500	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS00505	COG0248	Ppx GppA phosphatase
E0Z06_RS00515	COG5001	Diguanylate cyclase
E0Z06_RS00515	COG4251	negative regulation of phosphorylation
E0Z06_RS00515	COG2203	Gaf domain
E0Z06_RS00515	COG3706	GGDEF domain
E0Z06_RS00530	COG0805	protein transport
E0Z06_RS00535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0Z06_RS00540	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0Z06_RS00550	COG3165	ubiquinone biosynthetic process from chorismate
E0Z06_RS00560	COG3706	GGDEF domain
E0Z06_RS00575	COG1946	Acyl-CoA thioesterase
E0Z06_RS00580	COG2937	Belongs to the GPAT DAPAT family
E0Z06_RS00585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0Z06_RS00590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0Z06_RS00595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0Z06_RS00600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E0Z06_RS00630	COG0109	protoheme IX farnesyltransferase activity
E0Z06_RS00655	COG1040	competence protein
E0Z06_RS00685	COG4206	TonB-dependent receptor
E0Z06_RS00695	COG3710	Transcriptional regulator
E0Z06_RS00700	COG2183	response to ionizing radiation
E0Z06_RS00705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z06_RS00760	COG3118	belongs to the thioredoxin family
E0Z06_RS00765	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS00775	COG0668	transmembrane transport
E0Z06_RS00780	COG0204	Acyl-transferase
E0Z06_RS00785	COG0204	Acyl-transferase
E0Z06_RS00790	COG1166	arginine decarboxylase activity
E0Z06_RS00795	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E0Z06_RS00820	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E0Z06_RS00830	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E0Z06_RS00830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0Z06_RS00835	COG0754	glutathionylspermidine amidase activity
E0Z06_RS00855	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS00860	COG2153	protein acetylation
E0Z06_RS00865	COG4771	TonB-dependent receptor
E0Z06_RS00885	COG0848	biopolymer transport protein
E0Z06_RS00895	COG0811	peptide transport
E0Z06_RS00905	COG4774	siderophore transport
E0Z06_RS00910	COG3128	pkhd-type hydroxylase
E0Z06_RS00920	COG0405	Gamma-glutamyltransferase
E0Z06_RS00935	COG2204	response regulator
E0Z06_RS00945	COG2205	protein histidine kinase activity
E0Z06_RS00955	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E0Z06_RS00975	COG0840	transmembrane signaling receptor activity
E0Z06_RS00990	COG0473	3-isopropylmalate dehydrogenase activity
E0Z06_RS00995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0Z06_RS01000	COG0066	3-isopropylmalate dehydratase activity
E0Z06_RS01130	COG3384	dioxygenase
E0Z06_RS01195	COG2020	methyltransferase activity
E0Z06_RS01220	COG1573	uracil-dna glycosylase
E0Z06_RS01255	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E0Z06_RS01290	COG2356	endonuclease I
E0Z06_RS01300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E0Z06_RS01320	COG0606	chelatase, subunit chli
E0Z06_RS01325	COG0418	dihydroorotase activity
E0Z06_RS01330	COG2814	Major facilitator Superfamily
E0Z06_RS01340	COG2205	protein histidine kinase activity
E0Z06_RS01345	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS01365	COG0659	secondary active sulfate transmembrane transporter activity
E0Z06_RS01375	COG0840	transmembrane signaling receptor activity
E0Z06_RS01390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0Z06_RS01395	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E0Z06_RS01405	COG2111	Na H antiporter
E0Z06_RS01405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0Z06_RS01410	COG1006	Multisubunit Na H antiporter MnhC subunit
E0Z06_RS01415	COG0651	ATP synthesis coupled electron transport
E0Z06_RS01420	COG1863	multisubunit Na H antiporter MnhE subunit
E0Z06_RS01425	COG2212	antiporter activity
E0Z06_RS01440	COG1660	Displays ATPase and GTPase activities
E0Z06_RS01455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E0Z06_RS01460	COG1137	ATPase activity
E0Z06_RS01465	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
E0Z06_RS01475	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E0Z06_RS01490	COG1127	ABC transporter
E0Z06_RS01495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0Z06_RS01500	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0Z06_RS01505	COG2854	intermembrane phospholipid transfer
E0Z06_RS01515	COG5007	Belongs to the BolA IbaG family
E0Z06_RS01520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E0Z06_RS01530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0Z06_RS01535	COG3105	Protein conserved in bacteria
E0Z06_RS01540	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0Z06_RS01555	COG0723	plastoquinol--plastocyanin reductase activity
E0Z06_RS01560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E0Z06_RS01565	COG2857	Cytochrome c1
E0Z06_RS01570	COG0625	glutathione transferase activity
E0Z06_RS01575	COG2969	positive regulation of protein catabolic process
E0Z06_RS01580	COG0583	DNA-binding transcription factor activity
E0Z06_RS01585	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E0Z06_RS01590	COG2837	iron assimilation
E0Z06_RS01595	COG1438	arginine binding
E0Z06_RS01600	COG0039	L-malate dehydrogenase activity
E0Z06_RS01605	COG0142	geranyltranstransferase activity
E0Z06_RS01610	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E0Z06_RS01620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E0Z06_RS01635	COG0840	transmembrane signaling receptor activity
E0Z06_RS01640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0Z06_RS01645	COG2967	ApaG domain
E0Z06_RS01650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E0Z06_RS01660	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
E0Z06_RS01665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E0Z06_RS01685	COG0564	pseudouridine synthase activity
E0Z06_RS01690	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
E0Z06_RS01695	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E0Z06_RS01745	COG4152	abc transporter atp-binding protein
E0Z06_RS01765	COG3228	Belongs to the MtfA family
E0Z06_RS01785	COG4990	cell redox homeostasis
E0Z06_RS01785	COG3591	Belongs to the peptidase S1B family
E0Z06_RS01800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z06_RS01820	COG1823	symporter activity
E0Z06_RS01825	COG0583	DNA-binding transcription factor activity
E0Z06_RS01835	COG0435	Glutathione S-transferase
E0Z06_RS01850	COG0358	DNA primase activity
E0Z06_RS01855	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E0Z06_RS01860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E0Z06_RS01865	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E0Z06_RS01870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0Z06_RS01875	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0Z06_RS01885	COG0617	tRNA 3'-terminal CCA addition
E0Z06_RS01890	COG3267	Type II secretory pathway component ExeA
E0Z06_RS01890	COG3409	Peptidoglycan-binding domain 1 protein
E0Z06_RS01910	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0Z06_RS01910	COG0506	proline dehydrogenase activity
E0Z06_RS01910	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E0Z06_RS01920	COG4991	sh3 domain protein
E0Z06_RS01925	COG3025	triphosphatase activity
E0Z06_RS01930	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E0Z06_RS01940	COG1560	Kdo2-lipid A biosynthetic process
E0Z06_RS01945	COG1538	Outer membrane efflux protein
E0Z06_RS01950	COG0494	nUDIX hydrolase
E0Z06_RS01985	COG0204	Acyl-transferase
E0Z06_RS01990	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
E0Z06_RS02005	COG1757	Na H antiporter
E0Z06_RS02015	COG2927	DNA polymerase III (CHI subunit)
E0Z06_RS02020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0Z06_RS02025	COG0795	lipopolysaccharide-transporting ATPase activity
E0Z06_RS02030	COG0795	lipopolysaccharide-transporting ATPase activity
E0Z06_RS02080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0Z06_RS02095	COG2003	Belongs to the UPF0758 family
E0Z06_RS02105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z06_RS02135	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0Z06_RS02140	COG2217	Heavy metal translocating P-type atpase
E0Z06_RS02175	COG0789	Transcriptional regulator
E0Z06_RS02240	COG0210	DNA helicase
E0Z06_RS02245	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0Z06_RS02265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0Z06_RS02270	COG2862	Uncharacterized protein family, UPF0114
E0Z06_RS02275	COG1285	pathogenesis
E0Z06_RS02290	COG1136	(ABC) transporter
E0Z06_RS02300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
E0Z06_RS02305	COG0583	DNA-binding transcription factor activity
E0Z06_RS02315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z06_RS02340	COG0742	ribosomal rna small subunit methyltransferase
E0Z06_RS02355	COG0859	PFAM glycosyl transferase family 9
E0Z06_RS02360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E0Z06_RS02360	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E0Z06_RS02365	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E0Z06_RS02375	COG1519	Transferase
E0Z06_RS02380	COG3293	Transposase
E0Z06_RS02390	COG2081	HI0933 family
E0Z06_RS02405	COG1506	peptidase
E0Z06_RS02405	COG0823	Involved in the tonB-independent uptake of proteins
E0Z06_RS02405	COG4946	Tricorn protease homolog
E0Z06_RS02420	COG2203	Gaf domain
E0Z06_RS02420	COG3706	GGDEF domain
E0Z06_RS02420	COG4251	negative regulation of phosphorylation
E0Z06_RS02420	COG5001	Diguanylate cyclase
E0Z06_RS02455	COG2050	protein possibly involved in aromatic compounds catabolism
E0Z06_RS02460	COG2962	Rard protein
E0Z06_RS02470	COG2823	Periplasmic or secreted lipoprotein
E0Z06_RS02480	COG0792	nuclease activity
E0Z06_RS02485	COG3107	peptidoglycan biosynthetic process
E0Z06_RS02490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0Z06_RS02510	COG4948	Mandelate Racemase Muconate Lactonizing
E0Z06_RS02515	COG1737	Transcriptional regulator
E0Z06_RS02525	COG0275	rRNA processing
E0Z06_RS02530	COG3116	cell division
E0Z06_RS02535	COG0768	penicillin binding
E0Z06_RS02540	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0Z06_RS02545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E0Z06_RS02550	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0Z06_RS02560	COG0772	Belongs to the SEDS family
E0Z06_RS02565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E0Z06_RS02570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0Z06_RS02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0Z06_RS02580	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0Z06_RS02585	COG0849	cell division
E0Z06_RS02590	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0Z06_RS02595	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E0Z06_RS02605	COG0653	protein targeting
E0Z06_RS02610	COG0494	nUDIX hydrolase
E0Z06_RS02625	COG0237	dephospho-CoA kinase activity
E0Z06_RS02675	COG3577	Aspartyl protease
E0Z06_RS02685	COG3725	Membrane protein required for beta-lactamase induction
E0Z06_RS02690	COG2186	Transcriptional regulator
E0Z06_RS02695	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E0Z06_RS02700	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0Z06_RS02705	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z06_RS02730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0Z06_RS02740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z06_RS02745	COG2066	Belongs to the glutaminase family
E0Z06_RS02765	COG3590	peptidase
E0Z06_RS02780	COG3112	Uncharacterised protein family (UPF0231)
E0Z06_RS02785	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0Z06_RS02790	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
E0Z06_RS02795	COG4988	ABC transporter
E0Z06_RS02800	COG4890	Cyd operon protein YbgT
E0Z06_RS02805	COG1294	oxidase, subunit
E0Z06_RS02820	COG4206	TonB-dependent receptor
E0Z06_RS02825	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E0Z06_RS02915	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0Z06_RS02930	COG0501	Belongs to the peptidase M48B family
E0Z06_RS02935	COG1704	LemA family
E0Z06_RS02940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0Z06_RS02955	COG3161	chorismate lyase activity
E0Z06_RS02960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0Z06_RS02970	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z06_RS03010	COG0742	ribosomal rna small subunit methyltransferase
E0Z06_RS03015	COG0552	protein localization to endoplasmic reticulum
E0Z06_RS03020	COG2884	Cell division ATP-binding protein ftsE
E0Z06_RS03025	COG2177	Part of the ABC transporter FtsEX involved in
E0Z06_RS03040	COG1136	(ABC) transporter
E0Z06_RS03050	COG4191	Histidine kinase
E0Z06_RS03050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0Z06_RS03060	COG1846	Transcriptional regulator
E0Z06_RS03065	COG1764	response to oxidative stress
E0Z06_RS03080	COG1487	ribonuclease activity
E0Z06_RS03095	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E0Z06_RS03100	COG2867	negative regulation of translational initiation
E0Z06_RS03105	COG2914	Belongs to the UPF0125 (RnfH) family
E0Z06_RS03110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z06_RS03115	COG0497	DNA recombination
E0Z06_RS03120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E0Z06_RS03125	COG1420	regulation of RNA biosynthetic process
E0Z06_RS03130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E0Z06_RS03140	COG5002	protein histidine kinase activity
E0Z06_RS03155	COG0443	Heat shock 70 kDa protein
E0Z06_RS03160	COG0484	heat shock protein binding
E0Z06_RS03165	COG4783	chaperone-mediated protein folding
E0Z06_RS03175	COG2814	Major facilitator Superfamily
E0Z06_RS03185	COG1979	alcohol dehydrogenase
E0Z06_RS03190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E0Z06_RS03195	COG0505	Belongs to the CarA family
E0Z06_RS03200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0Z06_RS03205	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z06_RS03210	COG1534	Rna-binding protein
E0Z06_RS03215	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E0Z06_RS03220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z06_RS03225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0Z06_RS03230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0Z06_RS03235	COG0149	triose-phosphate isomerase activity
E0Z06_RS03240	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E0Z06_RS03255	COG0779	Required for maturation of 30S ribosomal subunits
E0Z06_RS03260	COG0195	Participates in both transcription termination and antitermination
E0Z06_RS03265	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E0Z06_RS03270	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E0Z06_RS03275	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0Z06_RS03285	COG1185	polyribonucleotide nucleotidyltransferase activity
E0Z06_RS03305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E0Z06_RS03310	COG0321	lipoyl(octanoyl) transferase activity
E0Z06_RS03320	COG1686	Belongs to the peptidase S11 family
E0Z06_RS03325	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0Z06_RS03330	COG0772	Belongs to the SEDS family
E0Z06_RS03335	COG0768	penicillin binding
E0Z06_RS03340	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E0Z06_RS03345	COG0799	negative regulation of ribosome biogenesis
E0Z06_RS03350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E0Z06_RS03360	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
E0Z06_RS03365	COG0495	leucyl-tRNA aminoacylation
E0Z06_RS03375	COG0659	secondary active sulfate transmembrane transporter activity
E0Z06_RS03380	COG0589	response to stress
E0Z06_RS03410	COG1595	DNA-templated transcription, initiation
E0Z06_RS03420	COG1067	ATP-dependent peptidase activity
E0Z06_RS03430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E0Z06_RS03435	COG4535	Mg2 and Co2 transporter CorC
E0Z06_RS03440	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
E0Z06_RS03445	COG1702	phosphate starvation-inducible protein PhoH
E0Z06_RS03455	COG0697	spore germination
E0Z06_RS03470	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0Z06_RS03485	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0Z06_RS03500	COG0628	permease
E0Z06_RS03515	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0Z06_RS03550	COG1505	serine-type exopeptidase activity
E0Z06_RS03560	COG0813	purine-nucleoside phosphorylase activity
E0Z06_RS03565	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E0Z06_RS03570	COG4628	conserved protein (DUF2132)
E0Z06_RS03575	COG0473	3-isopropylmalate dehydrogenase activity
E0Z06_RS03590	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0Z06_RS03595	COG1611	Belongs to the LOG family
E0Z06_RS03615	COG5595	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310)
E0Z06_RS03645	COG3098	single-species biofilm formation
E0Z06_RS03650	COG0564	pseudouridine synthase activity
E0Z06_RS03670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
E0Z06_RS03675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E0Z06_RS03680	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0Z06_RS03690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z06_RS03695	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E0Z06_RS03700	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0Z06_RS03705	COG1643	Atp-dependent helicase
E0Z06_RS03710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E0Z06_RS03715	COG0457	Tetratricopeptide repeat
E0Z06_RS03715	COG3710	Transcriptional regulator
E0Z06_RS03725	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS03730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E0Z06_RS03735	COG0540	Belongs to the ATCase OTCase family
E0Z06_RS03740	COG1981	membrane
E0Z06_RS03745	COG0038	chloride channel
E0Z06_RS03760	COG2211	Major facilitator Superfamily
E0Z06_RS03770	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0Z06_RS03780	COG2813	Specifically methylates the guanine in position
E0Z06_RS03790	COG0271	Belongs to the BolA IbaG family
E0Z06_RS03795	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0Z06_RS03800	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E0Z06_RS03805	COG1805	sodium ion transport
E0Z06_RS03815	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E0Z06_RS03820	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
E0Z06_RS03825	COG2871	sodium ion transport
E0Z06_RS03830	COG1477	protein flavinylation
E0Z06_RS03840	COG2205	protein histidine kinase activity
E0Z06_RS03840	COG0784	Response regulator, receiver
E0Z06_RS03850	COG2974	May be involved in recombination
E0Z06_RS03855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0Z06_RS03855	COG4191	Histidine kinase
E0Z06_RS03860	COG4753	response regulator
E0Z06_RS03860	COG2207	Transcriptional regulator
E0Z06_RS03880	COG0083	homoserine kinase activity
E0Z06_RS03890	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E0Z06_RS03900	COG0166	Belongs to the GPI family
E0Z06_RS03905	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0Z06_RS03920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0Z06_RS03925	COG0069	glutamate synthase activity
E0Z06_RS03930	COG1619	proteins homologs of microcin C7 resistance protein MccF
E0Z06_RS03935	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS03940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E0Z06_RS03945	COG0716	FMN binding
E0Z06_RS03950	COG4974	Belongs to the 'phage' integrase family
E0Z06_RS03955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0Z06_RS03960	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0Z06_RS03970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E0Z06_RS04005	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS04055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0Z06_RS04100	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS04115	COG0739	heme binding
E0Z06_RS04135	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E0Z06_RS04145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E0Z06_RS04150	COG1595	DNA-templated transcription, initiation
E0Z06_RS04155	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
E0Z06_RS04165	COG3086	response to oxidative stress
E0Z06_RS04170	COG0481	GTPase activity
E0Z06_RS04180	COG0571	ribonuclease III activity
E0Z06_RS04190	COG1381	Involved in DNA repair and RecF pathway recombination
E0Z06_RS04195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0Z06_RS04200	COG0736	holo-[acyl-carrier-protein] synthase activity
E0Z06_RS04210	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0Z06_RS04215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0Z06_RS04220	COG3956	TIGRFAM MazG family protein
E0Z06_RS04245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E0Z06_RS04250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E0Z06_RS04265	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E0Z06_RS04270	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E0Z06_RS04280	COG4942	peptidase
E0Z06_RS04280	COG1388	LysM domain
E0Z06_RS04295	COG3135	benzoate transporter
E0Z06_RS04305	COG1546	Belongs to the CinA family
E0Z06_RS04315	COG0328	RNA-DNA hybrid ribonuclease activity
E0Z06_RS04320	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0Z06_RS04355	COG2194	sulfuric ester hydrolase activity
E0Z06_RS04360	COG0642	Histidine kinase
E0Z06_RS04375	COG1368	sulfuric ester hydrolase activity
E0Z06_RS04385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z06_RS04395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0Z06_RS04400	COG0730	response to heat
E0Z06_RS04415	COG5265	(ABC) transporter
E0Z06_RS04420	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS04430	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0Z06_RS04435	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E0Z06_RS04450	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0Z06_RS04455	COG4106	trans-aconitate 2-methyltransferase activity
E0Z06_RS04470	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E0Z06_RS04475	COG0217	transcriptional regulatory protein
E0Z06_RS04480	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E0Z06_RS04485	COG0632	four-way junction helicase activity
E0Z06_RS04490	COG2255	four-way junction helicase activity
E0Z06_RS04495	COG0824	Thioesterase
E0Z06_RS04500	COG0811	peptide transport
E0Z06_RS04515	COG0823	Involved in the tonB-independent uptake of proteins
E0Z06_RS04520	COG2885	chlorophyll binding
E0Z06_RS04525	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
E0Z06_RS04550	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E0Z06_RS04655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0Z06_RS04660	COG0732	type I restriction modification DNA specificity domain
E0Z06_RS04665	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E0Z06_RS04715	COG0339	signal peptide processing
E0Z06_RS04720	COG0217	transcriptional regulatory protein
E0Z06_RS04750	COG3706	GGDEF domain
E0Z06_RS04760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E0Z06_RS04765	COG1047	Peptidyl-prolyl cis-trans
E0Z06_RS04775	COG0133	tryptophan synthase activity
E0Z06_RS04780	COG0134	indole-3-glycerol-phosphate synthase activity
E0Z06_RS04780	COG0135	phosphoribosylanthranilate isomerase activity
E0Z06_RS04785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E0Z06_RS04790	COG0512	Glutamine amidotransferase of anthranilate synthase
E0Z06_RS04795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0Z06_RS04800	COG0613	PHP domain protein
E0Z06_RS04805	COG0009	L-threonylcarbamoyladenylate synthase
E0Z06_RS04815	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E0Z06_RS04820	COG1187	pseudouridine synthase activity
E0Z06_RS04825	COG4221	oxidoreductase activity
E0Z06_RS04835	COG4585	Histidine kinase
E0Z06_RS04840	COG2197	response regulator
E0Z06_RS04845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0Z06_RS04850	COG2350	Protein conserved in bacteria
E0Z06_RS04855	COG0733	neurotransmitter:sodium symporter activity
E0Z06_RS04860	COG0442	prolyl-tRNA aminoacylation
E0Z06_RS04870	COG1720	tRNA m6t6A37 methyltransferase activity
E0Z06_RS04875	COG0288	reversible hydration of carbon dioxide
E0Z06_RS04885	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z06_RS04890	COG2267	carboxylic ester hydrolase activity
E0Z06_RS04895	COG0616	signal peptide processing
E0Z06_RS04900	COG0500	methyltransferase
E0Z06_RS04905	COG1301	dicarboxylic acid transport
E0Z06_RS04920	COG3724	N-succinylarginine dihydrolase activity
E0Z06_RS04960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0Z06_RS04975	COG0101	tRNA pseudouridine synthase activity
E0Z06_RS04980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E0Z06_RS04985	COG0285	dihydrofolate synthase activity
E0Z06_RS04995	COG1286	toxin biosynthetic process
E0Z06_RS05000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E0Z06_RS05030	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z06_RS05035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0Z06_RS05040	COG0215	cysteine-tRNA ligase activity
E0Z06_RS05045	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
E0Z06_RS05070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0Z06_RS05075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E0Z06_RS05080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E0Z06_RS05085	COG0544	peptidyl-prolyl cis-trans isomerase activity
E0Z06_RS05090	COG0740	serine-type endopeptidase activity
E0Z06_RS05095	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E0Z06_RS05100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E0Z06_RS05105	COG0776	regulation of translation
E0Z06_RS05110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z06_RS05115	COG4172	Belongs to the ABC transporter superfamily
E0Z06_RS05125	COG4171	peptide transport system, permease
E0Z06_RS05130	COG0601	transmembrane transport
E0Z06_RS05135	COG0747	negative chemotaxis
E0Z06_RS05140	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
E0Z06_RS05145	COG1842	Phage shock protein A
E0Z06_RS05160	COG3106	COG3106 Predicted ATPase
E0Z06_RS05165	COG3768	UPF0283 membrane protein
E0Z06_RS05170	COG0626	cystathionine gamma-synthase activity
E0Z06_RS05180	COG2154	pterin-4-alpha-carbinolamine dehydratase
E0Z06_RS05195	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E0Z06_RS05205	COG0625	glutathione transferase activity
E0Z06_RS05210	COG0835	chemotaxis
E0Z06_RS05210	COG0784	Response regulator, receiver
E0Z06_RS05225	COG1388	LysM domain
E0Z06_RS05225	COG0741	lytic transglycosylase activity
E0Z06_RS05230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0Z06_RS05235	COG2226	methyltransferase
E0Z06_RS05245	COG3122	Protein conserved in bacteria
E0Z06_RS05250	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS05255	COG1278	Cold shock
E0Z06_RS05260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0Z06_RS05265	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E0Z06_RS05270	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E0Z06_RS05275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0Z06_RS05275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0Z06_RS05290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E0Z06_RS05295	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0Z06_RS05305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E0Z06_RS05310	COG3706	GGDEF domain
E0Z06_RS05315	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E0Z06_RS05320	COG0142	geranyltranstransferase activity
E0Z06_RS05330	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E0Z06_RS05335	COG1360	Flagellar Motor Protein
E0Z06_RS05340	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0Z06_RS05340	COG0301	tRNA thio-modification
E0Z06_RS05345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E0Z06_RS05355	COG1666	GTP binding
E0Z06_RS05360	COG4206	TonB-dependent receptor
E0Z06_RS05370	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0Z06_RS05375	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E0Z06_RS05385	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z06_RS05390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z06_RS05420	COG0189	ligase activity
E0Z06_RS05425	COG0598	Magnesium transport protein CorA
E0Z06_RS05430	COG0672	)-iron permease
E0Z06_RS05440	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0Z06_RS05455	COG1872	DUF167
E0Z06_RS05460	COG0762	integral membrane protein
E0Z06_RS05465	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E0Z06_RS05470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E0Z06_RS05485	COG0517	IMP dehydrogenase activity
E0Z06_RS05490	COG0741	lytic transglycosylase activity
E0Z06_RS05500	COG0517	IMP dehydrogenase activity
E0Z06_RS05500	COG0516	GMP reductase activity
E0Z06_RS05510	COG0140	phosphoribosyl-ATP diphosphatase activity
E0Z06_RS05510	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E0Z06_RS05525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E0Z06_RS05530	COG0131	Imidazoleglycerol-phosphate dehydratase
E0Z06_RS05530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E0Z06_RS05535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0Z06_RS05540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0Z06_RS05545	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E0Z06_RS05560	COG1199	ATP-dependent helicase activity
E0Z06_RS05565	COG1214	PFAM Peptidase M22, glycoprotease
E0Z06_RS05575	COG0300	oxidoreductase activity
E0Z06_RS05590	COG1785	Belongs to the alkaline phosphatase family
E0Z06_RS05600	COG0318	PFAM AMP-dependent synthetase and ligase
E0Z06_RS05625	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
E0Z06_RS05630	COG2894	cell division
E0Z06_RS05635	COG0850	regulation of cytokinetic process
E0Z06_RS05645	COG2951	lytic endotransglycosylase activity
E0Z06_RS05650	COG0179	Fumarylacetoacetate (FAA) hydrolase
E0Z06_RS05655	COG2983	Belongs to the UPF0260 family
E0Z06_RS05675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0Z06_RS05690	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS05710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z06_RS05720	COG0386	Belongs to the glutathione peroxidase family
E0Z06_RS05725	COG2084	Dehydrogenase
E0Z06_RS05735	COG5642	Protein of unknown function (DUF2384)
E0Z06_RS05740	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E0Z06_RS05745	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
E0Z06_RS05755	COG4770	biotin carboxylase activity
E0Z06_RS05765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0Z06_RS05770	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS05780	COG0183	Belongs to the thiolase family
E0Z06_RS05790	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS05795	COG1024	Enoyl-CoA hydratase
E0Z06_RS05800	COG1024	Enoyl-CoA hydratase
E0Z06_RS05825	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E0Z06_RS05895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z06_RS05905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z06_RS05925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0Z06_RS05930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0Z06_RS05945	COG1032	radical SAM domain protein
E0Z06_RS05955	COG2373	Large extracellular alpha-helical protein
E0Z06_RS05960	COG4953	penicillin-binding protein 1C
E0Z06_RS05965	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0Z06_RS05995	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E0Z06_RS06005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0Z06_RS06010	COG0577	efflux transmembrane transporter activity
E0Z06_RS06010	COG1136	(ABC) transporter
E0Z06_RS06015	COG1136	(ABC) transporter
E0Z06_RS06040	COG1678	Uncharacterized ACR, COG1678
E0Z06_RS06045	COG0189	ligase activity
E0Z06_RS06050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E0Z06_RS06055	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
E0Z06_RS06060	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0Z06_RS06065	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E0Z06_RS06070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0Z06_RS06090	COG0811	peptide transport
E0Z06_RS06095	COG0811	peptide transport
E0Z06_RS06100	COG0848	biopolymer transport protein
E0Z06_RS06115	COG2204	response regulator
E0Z06_RS06130	COG2850	peptidyl-arginine hydroxylation
E0Z06_RS06135	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0Z06_RS06145	COG0482	sulfurtransferase activity
E0Z06_RS06160	COG1278	Cold shock
E0Z06_RS06165	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E0Z06_RS06170	COG0542	response to heat
E0Z06_RS06175	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E0Z06_RS06180	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E0Z06_RS06185	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E0Z06_RS06190	COG0492	ferredoxin-NADP+ reductase activity
E0Z06_RS06200	COG1272	protein, Hemolysin III
E0Z06_RS06215	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E0Z06_RS06220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0Z06_RS06230	COG0729	surface antigen
E0Z06_RS06240	COG0367	asparagine synthase
E0Z06_RS06250	COG1793	dna ligase
E0Z06_RS06255	COG4555	ABC transporter
E0Z06_RS06260	COG1668	transmembrane transport
E0Z06_RS06270	COG2988	succinylglutamate desuccinylase activity
E0Z06_RS06280	COG0346	lactoylglutathione lyase activity
E0Z06_RS06285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E0Z06_RS06295	COG4659	FMN binding
E0Z06_RS06300	COG4658	electron transport chain
E0Z06_RS06310	COG2878	Part of a membrane complex involved in electron transport
E0Z06_RS06315	COG4657	Part of a membrane complex involved in electron transport
E0Z06_RS06320	COG2200	EAL domain
E0Z06_RS06320	COG2199	diguanylate cyclase activity
E0Z06_RS06320	COG2203	Gaf domain
E0Z06_RS06340	COG0534	Mate efflux family protein
E0Z06_RS06345	COG0556	nucleotide-excision repair
E0Z06_RS06370	COG0427	acetyl-CoA hydrolase
E0Z06_RS06375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E0Z06_RS06435	COG1506	peptidase
E0Z06_RS06435	COG0823	Involved in the tonB-independent uptake of proteins
E0Z06_RS06440	COG0183	Belongs to the thiolase family
E0Z06_RS06450	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E0Z06_RS06460	COG0537	adenosine 5'-monophosphoramidase activity
E0Z06_RS06465	COG0737	Belongs to the 5'-nucleotidase family
E0Z06_RS06485	COG3436	PFAM IS66 Orf2 family protein
E0Z06_RS06510	COG1522	sequence-specific DNA binding
E0Z06_RS06515	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0Z06_RS06535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E0Z06_RS06545	COG1285	pathogenesis
E0Z06_RS06550	COG4651	solute:proton antiporter activity
E0Z06_RS06550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0Z06_RS06595	COG0527	aspartate kinase activity
E0Z06_RS06600	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E0Z06_RS06605	COG0602	queuosine metabolic process
E0Z06_RS06635	COG1393	Belongs to the ArsC family
E0Z06_RS06640	COG4783	chaperone-mediated protein folding
E0Z06_RS06650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0Z06_RS06655	COG2716	regulation of RNA biosynthetic process
E0Z06_RS06660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0Z06_RS06670	COG2095	MarC family integral membrane protein
E0Z06_RS06690	COG0072	phenylalanine-tRNA ligase activity
E0Z06_RS06695	COG0776	regulation of translation
E0Z06_RS06705	COG0415	Belongs to the DNA photolyase family
E0Z06_RS06725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0Z06_RS06745	COG3083	sulfuric ester hydrolase activity
E0Z06_RS06750	COG3082	Protein of unknown function (DUF1414)
E0Z06_RS06755	COG3081	Nucleoid-associated protein
E0Z06_RS06760	COG1876	peptidase activity
E0Z06_RS06765	COG1393	Belongs to the ArsC family
E0Z06_RS06775	COG3092	negative regulation of chromosome organization
E0Z06_RS06780	COG0708	Exodeoxyribonuclease III
E0Z06_RS06790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E0Z06_RS06810	COG3012	SEC-C Motif Domain Protein
E0Z06_RS06850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E0Z06_RS06855	COG2022	thiamine diphosphate biosynthetic process
E0Z06_RS06865	COG0352	thiamine-phosphate diphosphorylase activity
E0Z06_RS06880	COG2925	Exonuclease
E0Z06_RS06890	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS06895	COG0022	dehydrogenase e1 component
E0Z06_RS06905	COG1446	asparaginase
E0Z06_RS06910	COG1643	Atp-dependent helicase
E0Z06_RS06925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
E0Z06_RS06940	COG0477	Major facilitator Superfamily
E0Z06_RS06945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z06_RS06945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z06_RS06950	COG0489	protein tyrosine kinase activity
E0Z06_RS06955	COG0717	Belongs to the dCTP deaminase family
E0Z06_RS06960	COG0625	glutathione transferase activity
E0Z06_RS06985	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E0Z06_RS06990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E0Z06_RS06995	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
E0Z06_RS07000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E0Z06_RS07005	COG2855	membrane
E0Z06_RS07035	COG1278	Cold shock
E0Z06_RS07040	COG0686	Belongs to the AlaDH PNT family
E0Z06_RS07050	COG1674	ftsk spoiiie
E0Z06_RS07050	COG0531	amino acid
E0Z06_RS07055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E0Z06_RS07060	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0Z06_RS07065	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E0Z06_RS07070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E0Z06_RS07075	COG2920	part of a sulfur-relay system
E0Z06_RS07095	COG0670	Belongs to the BI1 family
E0Z06_RS07110	COG2197	response regulator
E0Z06_RS07115	COG0322	excinuclease ABC activity
E0Z06_RS07145	COG0471	metal ion transport
E0Z06_RS07150	COG1187	pseudouridine synthase activity
E0Z06_RS07175	COG0735	belongs to the Fur family
E0Z06_RS07200	COG0596	Alpha beta hydrolase
E0Z06_RS07205	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
E0Z06_RS07210	COG0033	Phosphoglucomutase
E0Z06_RS07215	COG3706	GGDEF domain
E0Z06_RS07220	COG2988	succinylglutamate desuccinylase activity
E0Z06_RS07225	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E0Z06_RS07230	COG0022	dehydrogenase e1 component
E0Z06_RS07235	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0Z06_RS07245	COG0515	serine threonine protein kinase
E0Z06_RS07250	COG1956	GAF domain-containing protein
E0Z06_RS07265	COG0793	Belongs to the peptidase S41A family
E0Z06_RS07270	COG0733	neurotransmitter:sodium symporter activity
E0Z06_RS07275	COG1757	Na H antiporter
E0Z06_RS07280	COG0308	aminopeptidase N
E0Z06_RS07310	COG2902	Dehydrogenase
E0Z06_RS07315	COG0167	dihydroorotate dehydrogenase activity
E0Z06_RS07330	COG1115	amino acid carrier protein
E0Z06_RS07340	COG1737	Transcriptional regulator
E0Z06_RS07345	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E0Z06_RS07355	COG0129	dihydroxy-acid dehydratase activity
E0Z06_RS07360	COG0837	glucose binding
E0Z06_RS07365	COG0800	Aldolase
E0Z06_RS07370	COG0488	(ABC) transporter
E0Z06_RS07375	COG0783	Belongs to the Dps family
E0Z06_RS07385	COG0281	malic enzyme
E0Z06_RS07395	COG0625	glutathione transferase activity
E0Z06_RS07405	COG0017	Asparaginyl-tRNA synthetase
E0Z06_RS07420	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E0Z06_RS07425	COG0156	8-amino-7-oxononanoate synthase activity
E0Z06_RS07435	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E0Z06_RS07440	COG3340	Belongs to the peptidase S51 family
E0Z06_RS07445	COG0501	Belongs to the peptidase M48B family
E0Z06_RS07450	COG2824	Alkylphosphonate utilization operon protein PhnA
E0Z06_RS07455	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E0Z06_RS07460	COG4946	Tricorn protease homolog
E0Z06_RS07460	COG0793	Belongs to the peptidase S41A family
E0Z06_RS07480	COG0714	Associated with various cellular activities
E0Z06_RS07485	COG2197	response regulator
E0Z06_RS07490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0Z06_RS07495	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E0Z06_RS07505	COG3293	Transposase
E0Z06_RS07515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0Z06_RS07515	COG0574	Belongs to the PEP-utilizing enzyme family
E0Z06_RS07520	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E0Z06_RS07525	COG2258	MOSC domain
E0Z06_RS07575	COG0488	(ABC) transporter
E0Z06_RS07590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0Z06_RS07615	COG1607	acyl-coa hydrolase
E0Z06_RS07620	COG2972	Histidine kinase
E0Z06_RS07630	COG0205	6-phosphofructokinase activity
E0Z06_RS07635	COG0697	spore germination
E0Z06_RS07640	COG1132	(ABC) transporter
E0Z06_RS07650	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0Z06_RS07655	COG4807	Protein conserved in bacteria
E0Z06_RS07660	COG0247	lactate metabolic process
E0Z06_RS07660	COG0277	FAD linked oxidase domain protein
E0Z06_RS07675	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
E0Z06_RS07685	COG1280	lysine exporter protein (LysE YggA)
E0Z06_RS07690	COG1054	Belongs to the UPF0176 family
E0Z06_RS07695	COG3038	cytochrome b561
E0Z06_RS07710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0Z06_RS07715	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0Z06_RS07720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0Z06_RS07745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E0Z06_RS07750	COG0539	negative regulation of cytoplasmic translation
E0Z06_RS07755	COG0776	regulation of translation
E0Z06_RS07765	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E0Z06_RS07770	COG0284	orotidine-5'-phosphate decarboxylase activity
E0Z06_RS07815	COG0589	response to stress
E0Z06_RS07820	COG0659	secondary active sulfate transmembrane transporter activity
E0Z06_RS07830	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0Z06_RS07840	COG0798	PFAM Bile acid sodium symporter
E0Z06_RS07845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0Z06_RS07850	COG0640	Transcriptional regulator
E0Z06_RS07865	COG0431	NADPH-dependent FMN reductase
E0Z06_RS07870	COG2072	flavoprotein involved in K transport
E0Z06_RS07880	COG0778	Nitroreductase
E0Z06_RS07885	COG1902	pentaerythritol trinitrate reductase activity
E0Z06_RS07885	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0Z06_RS07890	COG0616	signal peptide processing
E0Z06_RS07895	COG0252	asparaginase activity
E0Z06_RS07905	COG3139	Protein of unknown function (DUF1315)
E0Z06_RS07915	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0Z06_RS07920	COG2866	Carboxypeptidase
E0Z06_RS07940	COG0753	catalase activity
E0Z06_RS07945	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
E0Z06_RS07950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
E0Z06_RS07955	COG1640	4-alpha-glucanotransferase
E0Z06_RS07960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E0Z06_RS07965	COG0676	glucose-6-phosphate 1-epimerase activity
E0Z06_RS07975	COG3278	Belongs to the heme-copper respiratory oxidase family
E0Z06_RS07990	COG2010	Cytochrome c
E0Z06_RS08000	COG2217	Heavy metal translocating P-type atpase
E0Z06_RS08015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0Z06_RS08020	COG0589	response to stress
E0Z06_RS08040	COG1115	amino acid carrier protein
E0Z06_RS08045	COG3141	response to X-ray
E0Z06_RS08050	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E0Z06_RS08075	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0Z06_RS08080	COG0372	Belongs to the citrate synthase family
E0Z06_RS08085	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
E0Z06_RS08090	COG1802	Transcriptional regulator
E0Z06_RS08095	COG0084	hydrolase, TatD family'
E0Z06_RS08105	COG0470	DNA polymerase III
E0Z06_RS08110	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0Z06_RS08115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0Z06_RS08120	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0Z06_RS08125	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0Z06_RS08130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0Z06_RS08135	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z06_RS08145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E0Z06_RS08150	COG0416	fatty acid biosynthetic process
E0Z06_RS08155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E0Z06_RS08165	COG0424	maF-like protein
E0Z06_RS08180	COG1530	ribonuclease E activity
E0Z06_RS08225	COG1760	l-serine dehydratase
E0Z06_RS08230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0Z06_RS08250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0Z06_RS08260	COG0517	IMP dehydrogenase activity
E0Z06_RS08260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E0Z06_RS08275	COG0110	maltose O-acetyltransferase activity
E0Z06_RS08280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0Z06_RS08310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0Z06_RS08320	COG0045	succinate-CoA ligase (ADP-forming) activity
E0Z06_RS08325	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0Z06_RS08330	COG0567	Dehydrogenase, E1 component
E0Z06_RS08340	COG1053	succinate dehydrogenase
E0Z06_RS08345	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0Z06_RS08360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E0Z06_RS08365	COG2166	iron-sulfur cluster assembly
E0Z06_RS08370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E0Z06_RS08375	COG0564	pseudouridine synthase activity
E0Z06_RS08380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E0Z06_RS08390	COG1663	tetraacyldisaccharide 4'-kinase activity
E0Z06_RS08395	COG1132	(ABC) transporter
E0Z06_RS08400	COG2333	competence protein COMEC
E0Z06_RS08400	COG0658	competence protein
E0Z06_RS08410	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0Z06_RS08415	COG1136	(ABC) transporter
E0Z06_RS08420	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0Z06_RS08430	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0Z06_RS08475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0Z06_RS08495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E0Z06_RS08505	COG1024	Enoyl-CoA hydratase
E0Z06_RS08510	COG0405	Gamma-glutamyltransferase
E0Z06_RS08520	COG0564	pseudouridine synthase activity
E0Z06_RS08525	COG0564	pseudouridine synthase activity
E0Z06_RS08545	COG1595	DNA-templated transcription, initiation
E0Z06_RS08555	COG1104	cysteine desulfurase activity
E0Z06_RS08560	COG2186	Transcriptional regulator
E0Z06_RS08565	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E0Z06_RS08570	COG1902	pentaerythritol trinitrate reductase activity
E0Z06_RS08575	COG0454	-acetyltransferase
E0Z06_RS08580	COG0545	Peptidyl-prolyl cis-trans isomerase
E0Z06_RS08595	COG2814	Major facilitator Superfamily
E0Z06_RS08600	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E0Z06_RS08615	COG2062	phosphohistidine phosphatase, SixA
E0Z06_RS08620	COG1025	Belongs to the peptidase M16 family
E0Z06_RS08625	COG5001	Diguanylate cyclase
E0Z06_RS08625	COG3300	MHYT domain
E0Z06_RS08630	COG3085	chromosome segregation
E0Z06_RS08640	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0Z06_RS08640	COG1024	Enoyl-CoA hydratase
E0Z06_RS08645	COG0183	Belongs to the thiolase family
E0Z06_RS08650	COG0714	Associated with various cellular activities
E0Z06_RS08670	COG2304	oxidoreductase activity
E0Z06_RS08680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0Z06_RS08685	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
E0Z06_RS08690	COG1555	photosystem II stabilization
E0Z06_RS08690	COG1596	polysaccharide export
E0Z06_RS08710	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0Z06_RS08715	COG1090	epimerase
E0Z06_RS08720	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E0Z06_RS08725	COG4181	ATPase activity
E0Z06_RS08755	COG3409	Peptidoglycan-binding domain 1 protein
E0Z06_RS08755	COG3267	Type II secretory pathway component ExeA
E0Z06_RS08765	COG0489	protein tyrosine kinase activity
E0Z06_RS08785	COG2244	polysaccharide biosynthetic process
E0Z06_RS08810	COG0726	polysaccharide deacetylase
E0Z06_RS08820	COG1215	transferase activity, transferring glycosyl groups
E0Z06_RS08825	COG1045	serine acetyltransferase
E0Z06_RS08835	COG0726	polysaccharide deacetylase
E0Z06_RS08840	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS08895	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS08900	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS08925	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS08935	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
E0Z06_RS08960	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E0Z06_RS08965	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E0Z06_RS08970	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E0Z06_RS08985	COG0840	transmembrane signaling receptor activity
E0Z06_RS08990	COG3001	Fructosamine kinase
E0Z06_RS08995	COG0300	oxidoreductase activity
E0Z06_RS09005	COG0307	riboflavin synthase, alpha
E0Z06_RS09025	COG2217	Heavy metal translocating P-type atpase
E0Z06_RS09050	COG2132	Multicopper oxidase
E0Z06_RS09055	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS09060	COG5002	protein histidine kinase activity
E0Z06_RS09070	COG2223	nitrite transmembrane transporter activity
E0Z06_RS09075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0Z06_RS09080	COG0746	molybdenum cofactor guanylyltransferase activity
E0Z06_RS09085	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0Z06_RS09090	COG0315	cyclic pyranopterin monophosphate synthase activity
E0Z06_RS09095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E0Z06_RS09105	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E0Z06_RS09120	COG0840	transmembrane signaling receptor activity
E0Z06_RS09130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E0Z06_RS09135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0Z06_RS09140	COG0826	peptidase U32
E0Z06_RS09155	COG4206	TonB-dependent receptor
E0Z06_RS09165	COG0303	'Molybdopterin
E0Z06_RS09170	COG2197	response regulator
E0Z06_RS09175	COG2223	nitrite transmembrane transporter activity
E0Z06_RS09180	COG3850	Histidine kinase
E0Z06_RS09185	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E0Z06_RS09190	COG1140	nitrate reductase beta subunit
E0Z06_RS09195	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E0Z06_RS09200	COG2181	nitrate reductase activity
E0Z06_RS09205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z06_RS09210	COG2801	Transposase and inactivated derivatives
E0Z06_RS09365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0Z06_RS09370	COG3154	lipid carrier protein
E0Z06_RS09375	COG0826	peptidase U32
E0Z06_RS09380	COG0826	peptidase U32
E0Z06_RS09385	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0Z06_RS09390	COG0515	serine threonine protein kinase
E0Z06_RS09395	COG2223	nitrite transmembrane transporter activity
E0Z06_RS09415	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E0Z06_RS09425	COG3604	Transcriptional regulator
E0Z06_RS09435	COG1132	(ABC) transporter
E0Z06_RS09450	COG0463	Glycosyl transferase, family 2
E0Z06_RS09460	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS09465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0Z06_RS09510	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0Z06_RS09525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0Z06_RS09530	COG1187	pseudouridine synthase activity
E0Z06_RS09535	COG2814	Major facilitator Superfamily
E0Z06_RS09545	COG1253	flavin adenine dinucleotide binding
E0Z06_RS09555	COG1914	H( )-stimulated, divalent metal cation uptake system
E0Z06_RS09575	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E0Z06_RS09605	COG0667	Aldo Keto reductase
E0Z06_RS09615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0Z06_RS09625	COG3655	Transcriptional regulator
E0Z06_RS09650	COG3038	cytochrome b561
E0Z06_RS09655	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0Z06_RS09655	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0Z06_RS09665	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0Z06_RS09670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0Z06_RS09675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0Z06_RS09690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E0Z06_RS09695	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E0Z06_RS09700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0Z06_RS09715	COG1435	thymidine kinase activity
E0Z06_RS09720	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z06_RS09805	COG1459	type II secretion system
E0Z06_RS09810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E0Z06_RS09820	COG1216	Glycosyl transferase, family 2
E0Z06_RS09825	COG0463	Glycosyl transferase, family 2
E0Z06_RS09835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E0Z06_RS09840	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0Z06_RS09845	COG2852	Protein conserved in bacteria
E0Z06_RS09850	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E0Z06_RS09860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
E0Z06_RS09875	COG1091	dTDP-4-dehydrorhamnose reductase activity
E0Z06_RS09880	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0Z06_RS09900	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS09910	COG0438	transferase activity, transferring glycosyl groups
E0Z06_RS09925	COG0463	Glycosyl transferase, family 2
E0Z06_RS09925	COG1216	Glycosyl transferase, family 2
E0Z06_RS09935	COG1091	dTDP-4-dehydrorhamnose reductase activity
E0Z06_RS09945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
E0Z06_RS09950	COG1088	dTDP-glucose 4,6-dehydratase activity
E0Z06_RS09960	COG1596	polysaccharide export
E0Z06_RS09965	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0Z06_RS09975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E0Z06_RS09985	COG3104	oligopeptide transport
E0Z06_RS09995	COG2226	methyltransferase
E0Z06_RS10025	COG1138	Cytochrome C-type biogenesis protein
E0Z06_RS10030	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E0Z06_RS10035	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0Z06_RS10040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0Z06_RS10045	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0Z06_RS10050	COG4133	protoheme IX ABC transporter activity
E0Z06_RS10070	COG0835	chemotaxis
E0Z06_RS10080	COG1192	Involved in chromosome partitioning
E0Z06_RS10085	COG1360	Flagellar Motor Protein
E0Z06_RS10090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E0Z06_RS10095	COG2201	protein-glutamate methylesterase activity
E0Z06_RS10100	COG0784	Response regulator, receiver
E0Z06_RS10100	COG2198	Histidine kinase
E0Z06_RS10100	COG0643	Histidine kinase
E0Z06_RS10105	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E0Z06_RS10135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E0Z06_RS10140	COG1684	flagellar biosynthetic protein fliR
E0Z06_RS10145	COG1987	bacterial-type flagellum assembly
E0Z06_RS10195	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0Z06_RS10200	COG1766	The M ring may be actively involved in energy transduction
E0Z06_RS10205	COG1677	Flagellar hook-basal body complex protein FliE
E0Z06_RS10230	COG1086	Polysaccharide biosynthesis protein
E0Z06_RS10250	COG1083	cytidylyl-transferase
E0Z06_RS10260	COG2089	acid synthase
E0Z06_RS10265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E0Z06_RS10300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0Z06_RS10335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0Z06_RS10360	COG0562	UDP-galactopyranose mutase
E0Z06_RS10385	COG1516	flagellar protein fliS
E0Z06_RS10400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0Z06_RS10410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0Z06_RS10420	COG1256	bacterial-type flagellum assembly
E0Z06_RS10420	COG4786	Flagellar basal body rod
E0Z06_RS10425	COG3951	Flagellar rod assembly protein muramidase FlgJ
E0Z06_RS10425	COG1705	Flagellar rod assembly protein muramidase FlgJ
E0Z06_RS10430	COG1706	bacterial-type flagellum-dependent cell motility
E0Z06_RS10435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E0Z06_RS10440	COG4786	Flagellar basal body rod
E0Z06_RS10445	COG4787	bacterial-type flagellum-dependent cell motility
E0Z06_RS10455	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E0Z06_RS10465	COG1815	bacterial-type flagellum-dependent cell motility
E0Z06_RS10470	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E0Z06_RS10475	COG0784	Response regulator, receiver
E0Z06_RS10475	COG0835	chemotaxis
E0Z06_RS10515	COG3038	cytochrome b561
E0Z06_RS10530	COG1959	2 iron, 2 sulfur cluster binding
E0Z06_RS10580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E0Z06_RS10585	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E0Z06_RS10590	COG0730	response to heat
E0Z06_RS10595	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
E0Z06_RS10600	COG1051	belongs to the nudix hydrolase family
E0Z06_RS10605	COG3066	DNA modification
E0Z06_RS10615	COG0302	gtp cyclohydrolase
E0Z06_RS10625	COG0488	(ABC) transporter
E0Z06_RS10630	COG0596	Alpha beta hydrolase
E0Z06_RS10635	COG1448	Aminotransferase
E0Z06_RS10645	COG0023	Translation Initiation Factor
E0Z06_RS10660	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E0Z06_RS10685	COG1605	Chorismate mutase
E0Z06_RS10685	COG0077	Prephenate dehydratase
E0Z06_RS10690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E0Z06_RS10700	COG0287	Prephenate dehydrogenase
E0Z06_RS10700	COG1605	Chorismate mutase
E0Z06_RS10705	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E0Z06_RS10715	COG0335	large ribosomal subunit rRNA binding
E0Z06_RS10720	COG0336	Belongs to the RNA methyltransferase TrmD family
E0Z06_RS10725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E0Z06_RS10730	COG0228	four-way junction DNA binding
E0Z06_RS10735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0Z06_RS10740	COG4137	Cytochrome C assembly protein
E0Z06_RS10745	COG4536	flavin adenine dinucleotide binding
E0Z06_RS10755	COG2918	glutathione biosynthetic process
E0Z06_RS10760	COG0840	transmembrane signaling receptor activity
E0Z06_RS10765	COG1183	phosphatidylcholine synthase activity
E0Z06_RS10770	COG0542	response to heat
E0Z06_RS10780	COG0564	pseudouridine synthase activity
E0Z06_RS10805	COG0560	Phosphoserine phosphatase
E0Z06_RS10815	COG0084	hydrolase, TatD family'
E0Z06_RS10820	COG0259	pyridoxamine-phosphate oxidase activity
E0Z06_RS10825	COG0018	arginyl-trna synthetase
E0Z06_RS10850	COG0823	Involved in the tonB-independent uptake of proteins
E0Z06_RS10850	COG1506	peptidase
E0Z06_RS10850	COG4946	Tricorn protease homolog
E0Z06_RS10900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E0Z06_RS10920	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
E0Z06_RS10935	COG0583	DNA-binding transcription factor activity
E0Z06_RS10940	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
E0Z06_RS10945	COG1194	a g-specific adenine glycosylase
E0Z06_RS10950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0Z06_RS10955	COG2813	Specifically methylates the guanine in position
E0Z06_RS10970	COG4191	Histidine kinase
E0Z06_RS10970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0Z06_RS10975	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS10980	COG2198	Histidine kinase
E0Z06_RS10980	COG0784	Response regulator, receiver
E0Z06_RS10980	COG5002	protein histidine kinase activity
E0Z06_RS10990	COG0070	glutamate synthase
E0Z06_RS10990	COG0069	glutamate synthase activity
E0Z06_RS10990	COG0067	glutamate synthase
E0Z06_RS10995	COG0493	'glutamate synthase
E0Z06_RS11000	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
E0Z06_RS11005	COG1671	Belongs to the UPF0178 family
E0Z06_RS11010	COG0564	pseudouridine synthase activity
E0Z06_RS11015	COG3148	PFAM DTW domain containing protein
E0Z06_RS11020	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E0Z06_RS11030	COG0784	Response regulator, receiver
E0Z06_RS11030	COG3437	response regulator, receiver
E0Z06_RS11040	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0Z06_RS11045	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E0Z06_RS11050	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E0Z06_RS11055	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E0Z06_RS11060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0Z06_RS11075	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E0Z06_RS11080	COG0193	aminoacyl-tRNA hydrolase activity
E0Z06_RS11110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0Z06_RS11130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0Z06_RS11135	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS11140	COG2827	Endonuclease containing a URI domain
E0Z06_RS11165	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E0Z06_RS11170	COG4942	peptidase
E0Z06_RS11180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0Z06_RS11180	COG3008	intermembrane lipid transfer
E0Z06_RS11185	COG2995	paraquat-inducible protein a
E0Z06_RS11210	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E0Z06_RS11215	COG2137	regulation of response to DNA damage stimulus
E0Z06_RS11225	COG3591	Belongs to the peptidase S1B family
E0Z06_RS11225	COG4990	cell redox homeostasis
E0Z06_RS11245	COG1410	methionine synthase
E0Z06_RS11245	COG0646	methionine synthase
E0Z06_RS11250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E0Z06_RS11265	COG0189	ligase activity
E0Z06_RS11275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0Z06_RS11290	COG2885	chlorophyll binding
E0Z06_RS11300	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E0Z06_RS11305	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0Z06_RS11310	COG3706	GGDEF domain
E0Z06_RS11315	COG2201	protein-glutamate methylesterase activity
E0Z06_RS11335	COG0326	Molecular chaperone. Has ATPase activity
E0Z06_RS11340	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E0Z06_RS11345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E0Z06_RS11355	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E0Z06_RS11360	COG1506	peptidase
E0Z06_RS11365	COG4771	TonB-dependent receptor
E0Z06_RS11380	COG1199	ATP-dependent helicase activity
E0Z06_RS11385	COG0730	response to heat
E0Z06_RS11395	COG0123	including yeast histone deacetylase and acetoin utilization protein
E0Z06_RS11430	COG3706	GGDEF domain
E0Z06_RS11435	COG0037	tRNA processing
E0Z06_RS11445	COG0587	DNA-directed DNA polymerase activity
E0Z06_RS11450	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E0Z06_RS11455	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z06_RS11460	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z06_RS11465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0Z06_RS11470	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0Z06_RS11475	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
E0Z06_RS11485	COG0750	zinc metalloprotease
E0Z06_RS11490	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E0Z06_RS11495	COG0575	Belongs to the CDS family
E0Z06_RS11500	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0Z06_RS11505	COG0233	cytoplasmic translational termination
E0Z06_RS11520	COG0052	Belongs to the universal ribosomal protein uS2 family
E0Z06_RS11525	COG0024	Methionine aminopeptidase
E0Z06_RS11530	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E0Z06_RS11540	COG0076	glutamate decarboxylase activity
E0Z06_RS11545	COG0842	Transport permease protein
E0Z06_RS11550	COG1131	(ABC) transporter
E0Z06_RS11555	COG0163	prenyltransferase activity
E0Z06_RS11560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0Z06_RS11565	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E0Z06_RS11570	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E0Z06_RS11575	COG0840	transmembrane signaling receptor activity
E0Z06_RS11580	COG0281	malic enzyme
E0Z06_RS11585	COG0254	rRNA binding
E0Z06_RS11590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E0Z06_RS11595	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0Z06_RS11620	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0Z06_RS11635	COG1228	amidohydrolase
E0Z06_RS11645	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E0Z06_RS11650	COG2986	histidine ammonia-lyase
E0Z06_RS11660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E0Z06_RS11665	COG0456	acetyltransferase
E0Z06_RS11675	COG1295	ribonuclease BN
E0Z06_RS11680	COG1217	gtp-binding protein TYPA
E0Z06_RS11685	COG0174	glutamine synthetase
E0Z06_RS11695	COG3852	Histidine kinase
E0Z06_RS11710	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS11715	COG2205	protein histidine kinase activity
E0Z06_RS11725	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E0Z06_RS11735	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E0Z06_RS11740	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E0Z06_RS11750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0Z06_RS11755	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E0Z06_RS11760	COG4942	peptidase
E0Z06_RS11765	COG2861	carbohydrate metabolic process
E0Z06_RS11770	COG3300	MHYT domain
E0Z06_RS11770	COG5001	Diguanylate cyclase
E0Z06_RS11780	COG0784	Response regulator, receiver
E0Z06_RS11780	COG2198	Histidine kinase
E0Z06_RS11780	COG5002	protein histidine kinase activity
E0Z06_RS11810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0Z06_RS11815	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E0Z06_RS11820	COG1765	OsmC-like protein
E0Z06_RS11830	COG1012	belongs to the aldehyde dehydrogenase family
E0Z06_RS11840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0Z06_RS11860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E0Z06_RS11875	COG0338	D12 class N6 adenine-specific DNA methyltransferase
E0Z06_RS11885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E0Z06_RS11890	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E0Z06_RS11920	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E0Z06_RS11925	COG0165	Argininosuccinate lyase
E0Z06_RS11930	COG0137	argininosuccinate synthase activity
E0Z06_RS11935	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0Z06_RS11940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0Z06_RS11945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E0Z06_RS11955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0Z06_RS11960	COG0460	homoserine dehydrogenase
E0Z06_RS11960	COG0527	aspartate kinase activity
E0Z06_RS11965	COG0626	cystathionine gamma-synthase activity
E0Z06_RS11970	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
E0Z06_RS11980	COG3046	protein related to deoxyribodipyrimidine photolyase
E0Z06_RS11990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E0Z06_RS12025	COG4969	Belongs to the N-Me-Phe pilin family
E0Z06_RS12080	COG3275	phosphorelay sensor kinase activity
E0Z06_RS12085	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E0Z06_RS12090	COG1047	Peptidyl-prolyl cis-trans
E0Z06_RS12095	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E0Z06_RS12100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E0Z06_RS12105	COG0196	riboflavin kinase activity
E0Z06_RS12110	COG0728	peptidoglycan biosynthetic process
E0Z06_RS12115	COG0268	Binds directly to 16S ribosomal RNA
E0Z06_RS12120	COG0640	Transcriptional regulator
E0Z06_RS12140	COG1193	negative regulation of DNA recombination
E0Z06_RS12150	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0Z06_RS12155	COG3064	Membrane
E0Z06_RS12160	COG0427	acetyl-CoA hydrolase
E0Z06_RS12165	COG0123	including yeast histone deacetylase and acetoin utilization protein
E0Z06_RS12170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0Z06_RS12170	COG0047	phosphoribosylformylglycinamidine synthase activity
E0Z06_RS12175	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E0Z06_RS12190	COG0735	belongs to the Fur family
E0Z06_RS12205	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0Z06_RS12220	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E0Z06_RS12225	COG2965	DNA replication, synthesis of RNA primer
E0Z06_RS12230	COG0360	Binds together with S18 to 16S ribosomal RNA
E0Z06_RS12235	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0Z06_RS12240	COG0557	exoribonuclease II activity
E0Z06_RS12245	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E0Z06_RS12255	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E0Z06_RS12265	COG0330	HflC and HflK could
E0Z06_RS12270	COG0330	HflC and HflK could
E0Z06_RS12275	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0Z06_RS12280	COG1923	regulation of RNA biosynthetic process
E0Z06_RS12285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E0Z06_RS12290	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E0Z06_RS12300	COG0802	atpase or kinase
E0Z06_RS12305	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E0Z06_RS12315	COG0427	acetyl-CoA hydrolase
E0Z06_RS12325	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
E0Z06_RS12330	COG1162	GTPase activity
E0Z06_RS12335	COG0688	phosphatidylethanolamine metabolic process
E0Z06_RS12340	COG0584	glycerophosphoryl diester phosphodiesterase
E0Z06_RS12360	COG0459	protein refolding
E0Z06_RS12365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0Z06_RS12370	COG4232	protein-disulfide reductase activity
E0Z06_RS12375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E0Z06_RS12380	COG0511	ligase activity, forming carbon-carbon bonds
E0Z06_RS12385	COG0439	Biotin carboxylase
E0Z06_RS12390	COG2264	protein methyltransferase activity
E0Z06_RS12405	COG0784	Response regulator, receiver
E0Z06_RS12405	COG2198	Histidine kinase
E0Z06_RS12405	COG5002	protein histidine kinase activity
E0Z06_RS12410	COG0784	Response regulator, receiver
E0Z06_RS12415	COG4251	negative regulation of phosphorylation
E0Z06_RS12425	COG2204	response regulator
E0Z06_RS12540	COG0798	PFAM Bile acid sodium symporter
E0Z06_RS12575	COG4691	Plasmid stability protein
E0Z06_RS12600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0Z06_RS12600	COG0519	Catalyzes the synthesis of GMP from XMP
E0Z06_RS12605	COG0517	IMP dehydrogenase activity
E0Z06_RS12605	COG0516	GMP reductase activity
E0Z06_RS12610	COG1570	exodeoxyribonuclease VII activity
E0Z06_RS12635	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0Z06_RS12640	COG2976	Protein conserved in bacteria
E0Z06_RS12645	COG0124	histidyl-tRNA synthetase
E0Z06_RS12650	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E0Z06_RS12655	COG1426	Protein conserved in bacteria
E0Z06_RS12665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E0Z06_RS12670	COG0105	UTP biosynthetic process
E0Z06_RS12705	COG0822	iron-sulfur transferase activity
E0Z06_RS12710	COG1104	cysteine desulfurase activity
E0Z06_RS12715	COG1959	2 iron, 2 sulfur cluster binding
E0Z06_RS12725	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
E0Z06_RS12735	COG0151	Belongs to the GarS family
E0Z06_RS12745	COG3954	Phosphoribulokinase
E0Z06_RS12755	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E0Z06_RS12760	COG0138	bifunctional purine biosynthesis protein purh
E0Z06_RS12795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0Z06_RS12800	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0Z06_RS12805	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E0Z06_RS12810	COG1862	Preprotein translocase
E0Z06_RS12815	COG0343	queuine tRNA-ribosyltransferase activity
E0Z06_RS12825	COG0583	DNA-binding transcription factor activity
E0Z06_RS12830	COG0306	phosphate transporter
E0Z06_RS12835	COG1392	Phosphate transport regulator
E0Z06_RS12840	COG0704	Plays a role in the regulation of phosphate uptake
E0Z06_RS12850	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E0Z06_RS12855	COG0248	Ppx GppA phosphatase
E0Z06_RS12860	COG1473	amidohydrolase
E0Z06_RS12865	COG0519	Catalyzes the synthesis of GMP from XMP
E0Z06_RS12870	COG5002	protein histidine kinase activity
E0Z06_RS12875	COG0745	RESPONSE REGULATOR receiver
E0Z06_RS12900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E0Z06_RS12910	COG0573	inorganic phosphate transmembrane transporter activity
E0Z06_RS12915	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E0Z06_RS12920	COG1404	Belongs to the peptidase S8 family
E0Z06_RS12930	COG1063	alcohol dehydrogenase
E0Z06_RS12935	COG0156	8-amino-7-oxononanoate synthase activity
E0Z06_RS12960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0Z06_RS12975	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z06_RS13005	COG0681	Belongs to the peptidase S26 family
E0Z06_RS13030	COG4771	TonB-dependent receptor
E0Z06_RS13035	COG2610	gluconate transmembrane transporter activity
E0Z06_RS13040	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0Z06_RS13060	COG3842	ATPase activity
E0Z06_RS13065	COG1178	ABC-type Fe3 transport system permease component
E0Z06_RS13070	COG1840	ABC-type Fe3 transport system, periplasmic component
E0Z06_RS13080	COG2193	ferroxidase activity
E0Z06_RS13115	COG3201	nicotinamide mononucleotide transporter
E0Z06_RS13135	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E0Z06_RS13140	COG2239	Acts as a magnesium transporter
E0Z06_RS13160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E0Z06_RS13180	COG2003	Belongs to the UPF0758 family
E0Z06_RS13185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E0Z06_RS13210	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E0Z06_RS13215	COG1561	YicC-like family, N-terminal region
E0Z06_RS13225	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z06_RS13305	COG3150	esterase
E0Z06_RS13325	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z06_RS13335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0Z06_RS13370	COG2856	Zn peptidase
E0Z06_RS13425	COG1012	belongs to the aldehyde dehydrogenase family
E0Z06_RS13430	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0Z06_RS13435	COG1074	ATP-dependent DNA helicase activity
E0Z06_RS13440	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E0Z06_RS13450	COG1288	antiporter activity
E0Z06_RS13465	COG0583	DNA-binding transcription factor activity
E0Z06_RS13485	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
E0Z06_RS13515	COG2195	Cleaves the N-terminal amino acid of tripeptides
E0Z06_RS13530	COG0194	GDP metabolic process
E0Z06_RS13535	COG1758	RNA polymerase activity
E0Z06_RS13540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E0Z06_RS13555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0Z06_RS13560	COG4336	lyase activity
E0Z06_RS13575	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E0Z06_RS13580	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E0Z06_RS13585	COG1984	allophanate hydrolase subunit 2
E0Z06_RS13600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0Z06_RS13610	COG1201	RNA secondary structure unwinding
E0Z06_RS13650	COG3876	Protein conserved in bacteria
E0Z06_RS13665	COG1757	Na H antiporter
E0Z06_RS13680	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z06_RS13685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0Z06_RS13690	COG4771	TonB-dependent receptor
E0Z06_RS13710	COG4566	intracellular signal transduction
E0Z06_RS13725	COG1288	antiporter activity
E0Z06_RS13730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0Z06_RS13785	COG1104	cysteine desulfurase activity
E0Z06_RS13800	COG3550	peptidyl-serine autophosphorylation
E0Z06_RS13805	COG1061	Type III restriction enzyme res subunit
E0Z06_RS13815	COG1396	sequence-specific DNA binding
E0Z06_RS13825	COG3550	peptidyl-serine autophosphorylation
E0Z06_RS13830	COG3550	peptidyl-serine autophosphorylation
E0Z06_RS13880	COG5002	protein histidine kinase activity
E0Z06_RS13890	COG0312	modulator of DNA gyrase
E0Z06_RS13895	COG3028	Belongs to the UPF0307 family
E0Z06_RS13905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0Z06_RS13910	COG0312	modulator of DNA gyrase
E0Z06_RS13915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0Z06_RS13920	COG3164	Protein of unknown function
E0Z06_RS13925	COG1530	ribonuclease E activity
E0Z06_RS13930	COG0424	maF-like protein
E0Z06_RS13935	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
E0Z06_RS13940	COG1792	Involved in formation and maintenance of cell shape
E0Z06_RS13945	COG1077	Cell shape determining protein MreB Mrl
E0Z06_RS13990	COG0202	RNA polymerase activity
E0Z06_RS13995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E0Z06_RS14000	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E0Z06_RS14005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0Z06_RS14010	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E0Z06_RS14015	COG0201	protein transport
E0Z06_RS14020	COG0200	Binds to the 23S rRNA
E0Z06_RS14030	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0Z06_RS14035	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E0Z06_RS14040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E0Z06_RS14045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E0Z06_RS14050	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E0Z06_RS14055	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E0Z06_RS14060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E0Z06_RS14065	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E0Z06_RS14070	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E0Z06_RS14080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E0Z06_RS14085	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E0Z06_RS14090	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E0Z06_RS14095	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E0Z06_RS14105	COG0089	rRNA binding
E0Z06_RS14110	COG0088	Forms part of the polypeptide exit tunnel
E0Z06_RS14115	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0Z06_RS14120	COG0051	transcription antitermination factor activity, RNA binding
E0Z06_RS14125	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E0Z06_RS14130	COG1960	acyl-CoA dehydrogenase activity
E0Z06_RS14135	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0Z06_RS14140	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E0Z06_RS14145	COG0049	tRNA binding
E0Z06_RS14155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0Z06_RS14160	COG0085	RNA polymerase activity
E0Z06_RS14165	COG0222	ribosome binding
E0Z06_RS14170	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E0Z06_RS14175	COG0081	regulation of translation
E0Z06_RS14180	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E0Z06_RS14185	COG0250	Participates in transcription elongation, termination and antitermination
E0Z06_RS14200	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0Z06_RS14230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E0Z06_RS14230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E0Z06_RS14240	COG1136	(ABC) transporter
E0Z06_RS14240	COG0577	efflux transmembrane transporter activity
E0Z06_RS14290	COG0724	RNA recognition motif
E0Z06_RS14295	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0Z06_RS14310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0Z06_RS14315	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
E0Z06_RS14320	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E0Z06_RS14335	COG0545	Peptidyl-prolyl cis-trans isomerase
E0Z06_RS14345	COG2900	Belongs to the SlyX family
E0Z06_RS14355	COG0488	(ABC) transporter
E0Z06_RS14370	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0Z06_RS14375	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
E0Z06_RS14400	COG3089	Belongs to the UPF0270 family
E0Z06_RS14410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E0Z06_RS14415	COG1218	3'(2'),5'-bisphosphate nucleotidase
E0Z06_RS14420	COG0494	nUDIX hydrolase
E0Z06_RS14425	COG1011	Hydrolase
E0Z06_RS14435	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
E0Z06_RS14455	COG2165	general secretion pathway protein
E0Z06_RS14470	COG1459	type II secretion system
E0Z06_RS14475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E0Z06_RS14485	COG3031	protein transport across the cell outer membrane
E0Z06_RS14490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E0Z06_RS14495	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E0Z06_RS14505	COG2823	Periplasmic or secreted lipoprotein
E0Z06_RS14510	COG0420	3'-5' exonuclease activity
E0Z06_RS14515	COG0419	ATPase involved in DNA repair
E0Z06_RS14530	COG0668	transmembrane transport
E0Z06_RS14550	COG3078	GTPase activator activity
E0Z06_RS14570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0Z06_RS14570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0Z06_RS14585	COG0210	DNA helicase
E0Z06_RS14595	COG0330	HflC and HflK could
E0Z06_RS14605	COG0583	DNA-binding transcription factor activity
E0Z06_RS14610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0Z06_RS14615	COG3002	Belongs to the UPF0753 family
E0Z06_RS14625	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0Z06_RS14630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0Z06_RS14635	COG0175	sulfate reduction
E0Z06_RS14655	COG3634	alkyl hydroperoxide reductase activity
E0Z06_RS14665	COG2199	diguanylate cyclase activity
E0Z06_RS14675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E0Z06_RS14675	COG1648	precorrin-2 dehydrogenase activity
E0Z06_RS14680	COG0175	sulfate reduction
E0Z06_RS14685	COG2895	sulfate adenylyltransferase (ATP) activity
E0Z06_RS14690	COG0471	metal ion transport
E0Z06_RS14690	COG3273	potassium ion transport
E0Z06_RS14695	COG0529	Catalyzes the synthesis of activated sulfate
E0Z06_RS14705	COG1187	pseudouridine synthase activity
E0Z06_RS14725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0Z06_RS14730	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z06_RS14735	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0Z06_RS14765	COG0824	Thioesterase
E0Z06_RS14785	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0Z06_RS14790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0Z06_RS14800	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0Z06_RS14805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0Z06_RS14845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0Z06_RS14860	COG1131	(ABC) transporter
E0Z06_RS14880	COG3293	Transposase
E0Z06_RS14885	COG3313	Fe-S protein
E0Z06_RS14900	COG0129	dihydroxy-acid dehydratase activity
E0Z06_RS14920	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0Z06_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
E0Z06_RS14940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E0Z06_RS14945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0Z06_RS14965	COG1061	Type III restriction enzyme res subunit
E0Z06_RS14985	COG0659	secondary active sulfate transmembrane transporter activity
E0Z06_RS14990	COG0589	response to stress
E0Z06_RS15130	COG1396	sequence-specific DNA binding
E0Z06_RS15195	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E0Z06_RS15205	COG0732	type I restriction modification DNA specificity domain
E0Z06_RS15215	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E0Z06_RS15240	COG0629	single-stranded DNA binding
E0Z06_RS15245	COG2814	Major facilitator Superfamily
E0Z06_RS15250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0Z06_RS15260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0Z06_RS15265	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0Z06_RS15270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E0Z06_RS15275	COG0348	domain, Protein
E0Z06_RS15290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E0Z06_RS15295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0Z06_RS15320	COG2267	carboxylic ester hydrolase activity
E0Z06_RS15325	COG4585	Histidine kinase
E0Z06_RS15330	COG2197	response regulator
E0Z06_RS15355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E0Z06_RS15360	COG1349	DNA-binding transcription factor activity
E0Z06_RS15385	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0Z06_RS15410	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0Z06_RS15415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0Z06_RS15420	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E0Z06_RS15425	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E0Z06_RS15430	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0Z06_RS15435	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E0Z06_RS15445	COG0356	it plays a direct role in the translocation of protons across the membrane
E0Z06_RS15455	COG1475	DNA binding
E0Z06_RS15460	COG1192	Involved in chromosome partitioning
E0Z06_RS15465	COG0357	Ribosomal RNA small subunit methyltransferase G
E0Z06_RS15470	COG0445	tRNA wobble uridine modification
E0Z06_RS15475	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
E0Z06_RS15480	COG0513	Belongs to the DEAD box helicase family
E0Z06_RS15495	COG3118	belongs to the thioredoxin family
E0Z06_RS15500	COG1881	PFAM PEBP family protein
E0Z06_RS15505	COG2873	o-acetylhomoserine
E0Z06_RS15515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E0Z06_RS15520	COG0706	membrane insertase activity
E0Z06_RS15525	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E0Z06_RS15530	COG0594	ribonuclease P activity
E0Z06_RS15535	COG0230	Belongs to the bacterial ribosomal protein bL34 family