locus-tag	class	description
RL_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RL_RS00010	COG0424	maF-like protein
RL_RS00015	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RL_RS00020	COG0237	dephospho-CoA kinase activity
RL_RS00025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RL_RS00030	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RL_RS00035	COG3030	protein affecting phage T7 exclusion by the F plasmid
RL_RS00045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RL_RS00075	COG0435	Glutathione S-transferase
RL_RS00100	COG0135	phosphoribosylanthranilate isomerase activity
RL_RS00105	COG0133	tryptophan synthase activity
RL_RS00110	COG0159	tryptophan synthase activity
RL_RS00115	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RL_RS00120	COG0285	dihydrofolate synthase activity
RL_RS00130	COG1074	ATP-dependent DNA helicase activity
RL_RS00135	COG2887	Belongs to the helicase family. UvrD subfamily
RL_RS00140	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RL_RS00145	COG3178	'Phosphotransferase
RL_RS00150	COG2205	protein histidine kinase activity
RL_RS00155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RL_RS00160	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RL_RS00165	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RL_RS00165	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RL_RS00175	COG0642	Histidine kinase
RL_RS00180	COG0745	RESPONSE REGULATOR receiver
RL_RS00185	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RL_RS00200	COG1072	(Pantothenic acid kinase))
RL_RS00205	COG0140	phosphoribosyl-ATP diphosphatase activity
RL_RS00210	COG0107	imidazoleglycerol-phosphate synthase activity
RL_RS00215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RL_RS00230	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RL_RS00240	COG0131	Imidazoleglycerol-phosphate dehydratase
RL_RS00245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RL_RS00255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RL_RS00265	COG2124	cytochrome p450
RL_RS00270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RL_RS00285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RL_RS00295	COG1643	Atp-dependent helicase
RL_RS00300	COG2423	ornithine cyclodeaminase activity
RL_RS00335	COG0366	Alpha amylase catalytic
RL_RS00360	COG3459	Glycosyltransferase 36 associated
RL_RS00365	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS00370	COG0517	IMP dehydrogenase activity
RL_RS00375	COG4178	(ABC) transporter
RL_RS00410	COG2197	response regulator
RL_RS00425	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RL_RS00430	COG1215	transferase activity, transferring glycosyl groups
RL_RS00460	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RL_RS00465	COG0673	inositol 2-dehydrogenase activity
RL_RS00480	COG0673	inositol 2-dehydrogenase activity
RL_RS00485	COG1309	transcriptional regulator
RL_RS00495	COG1175	transmembrane transport
RL_RS00500	COG0395	ABC-type sugar transport system, permease component
RL_RS00510	COG3842	ATPase activity
RL_RS00525	COG0246	Mannitol dehydrogenase
RL_RS00530	COG1904	glucuronate isomerase
RL_RS00535	COG2900	Belongs to the SlyX family
RL_RS00540	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS00545	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RL_RS00565	COG0539	negative regulation of cytoplasmic translation
RL_RS00570	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RL_RS00575	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RL_RS00625	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RL_RS00635	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RL_RS00645	COG1185	polyribonucleotide nucleotidyltransferase activity
RL_RS00650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RL_RS00655	COG0596	Alpha beta hydrolase
RL_RS00660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RL_RS00665	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RL_RS00670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RL_RS00685	COG0779	Required for maturation of 30S ribosomal subunits
RL_RS00690	COG2814	Major facilitator Superfamily
RL_RS00700	COG2951	lytic endotransglycosylase activity
RL_RS00705	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RL_RS00710	COG2258	MOSC domain
RL_RS00715	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RL_RS00720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RL_RS00730	COG2816	NAD+ diphosphatase activity
RL_RS00735	COG2378	regulation of single-species biofilm formation
RL_RS00750	COG1605	Chorismate mutase
RL_RS00750	COG0077	Prephenate dehydratase
RL_RS00755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RL_RS00760	COG3474	cytochrome
RL_RS00770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS00795	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RL_RS00800	COG1396	sequence-specific DNA binding
RL_RS00810	COG0484	heat shock protein binding
RL_RS00815	COG0443	Heat shock 70 kDa protein
RL_RS00820	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RL_RS00835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RL_RS00840	COG5001	Diguanylate cyclase
RL_RS00840	COG3300	MHYT domain
RL_RS00850	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS00850	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS00855	COG1674	ftsk spoiiie
RL_RS00860	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RL_RS00860	COG0456	acetyltransferase
RL_RS00865	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RL_RS00870	COG3454	Phosphonate metabolism
RL_RS00875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RL_RS00885	COG3639	organic phosphonate transmembrane transporter activity
RL_RS00890	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RL_RS00900	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RL_RS00910	COG4778	phosphonate C-P lyase system protein PhnL
RL_RS00915	COG4107	phosphonate C-P lyase system protein PhnK
RL_RS00920	COG3627	carbon phosphorus lyase activity
RL_RS00925	COG3626	phosphonate metabolism
RL_RS00930	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RL_RS00935	COG3624	Phosphonate C-P lyase system protein PhnG
RL_RS00940	COG2188	Transcriptional regulator
RL_RS00945	COG0588	phosphoglycerate mutase activity
RL_RS00950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RL_RS00955	COG1132	(ABC) transporter
RL_RS00960	COG0837	glucose binding
RL_RS00965	COG1803	Methylglyoxal synthase
RL_RS00970	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
RL_RS00975	COG4166	transmembrane transport
RL_RS00980	COG4174	ABC transporter (Permease)
RL_RS00985	COG4239	(ABC) transporter, permease
RL_RS00990	COG4172	Belongs to the ABC transporter superfamily
RL_RS00995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RL_RS01005	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RL_RS01025	COG1522	sequence-specific DNA binding
RL_RS01040	COG1744	ABC transporter substrate-binding protein PnrA-like
RL_RS01045	COG3845	ABC transporter
RL_RS01050	COG1079	Belongs to the binding-protein-dependent transport system permease family
RL_RS01055	COG1079	Belongs to the binding-protein-dependent transport system permease family
RL_RS01065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RL_RS01070	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RL_RS01075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RL_RS01085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RL_RS01090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RL_RS01095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RL_RS01130	COG4964	Belongs to the GSP D family
RL_RS01160	COG1280	lysine exporter protein (LysE YggA)
RL_RS01170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RL_RS01185	COG0154	amidase activity
RL_RS01190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS01195	COG0601	transmembrane transport
RL_RS01200	COG0747	negative chemotaxis
RL_RS01220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RL_RS01230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RL_RS01240	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RL_RS01260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RL_RS01280	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RL_RS01295	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RL_RS01335	COG0481	GTPase activity
RL_RS01365	COG2137	regulation of response to DNA damage stimulus
RL_RS01390	COG0596	Alpha beta hydrolase
RL_RS01390	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RL_RS01395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RL_RS01400	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RL_RS01405	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RL_RS01410	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RL_RS01415	COG0072	phenylalanine-tRNA ligase activity
RL_RS01415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RL_RS01425	COG0667	Aldo Keto reductase
RL_RS01435	COG3685	Protein conserved in bacteria
RL_RS01480	COG1570	exodeoxyribonuclease VII activity
RL_RS01485	COG2249	NAD(P)H dehydrogenase (quinone) activity
RL_RS01490	COG1846	Transcriptional regulator
RL_RS01495	COG0697	spore germination
RL_RS01500	COG2309	aminopeptidase activity
RL_RS01505	COG0625	glutathione transferase activity
RL_RS01520	COG1393	Belongs to the ArsC family
RL_RS01535	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RL_RS01540	COG4221	oxidoreductase activity
RL_RS01550	COG0583	DNA-binding transcription factor activity
RL_RS01585	COG0667	Aldo Keto reductase
RL_RS01590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RL_RS01595	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
RL_RS01600	COG1335	isochorismatase
RL_RS01605	COG0583	DNA-binding transcription factor activity
RL_RS01625	COG0693	protein deglycase activity
RL_RS01635	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS01640	COG2814	Major facilitator Superfamily
RL_RS01645	COG0519	Catalyzes the synthesis of GMP from XMP
RL_RS01645	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RL_RS01690	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RL_RS01700	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RL_RS01710	COG1968	undecaprenyl-diphosphatase activity
RL_RS01730	COG0284	orotidine-5'-phosphate decarboxylase activity
RL_RS01740	COG3963	phosphatidate phosphatase activity
RL_RS01750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RL_RS01755	COG0792	nuclease activity
RL_RS01765	COG0189	ligase activity
RL_RS01785	COG0783	Belongs to the Dps family
RL_RS01790	COG2962	Rard protein
RL_RS01795	COG1522	sequence-specific DNA binding
RL_RS01805	COG0756	dUTP diphosphatase activity
RL_RS01810	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RL_RS01815	COG0583	DNA-binding transcription factor activity
RL_RS01845	COG2807	transmembrane transport
RL_RS01855	COG1741	Belongs to the pirin family
RL_RS01865	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RL_RS01870	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS01880	COG0583	DNA-binding transcription factor activity
RL_RS01890	COG2814	Major facilitator Superfamily
RL_RS01900	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RL_RS01920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RL_RS01925	COG2986	histidine ammonia-lyase
RL_RS01930	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RL_RS01935	COG2226	methyltransferase
RL_RS01940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RL_RS01945	COG1024	Enoyl-CoA hydratase
RL_RS01950	COG0268	Binds directly to 16S ribosomal RNA
RL_RS01955	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RL_RS01965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RL_RS01970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RL_RS01980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RL_RS01985	COG1420	regulation of RNA biosynthetic process
RL_RS01990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RL_RS02000	COG0071	Belongs to the small heat shock protein (HSP20) family
RL_RS02020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RL_RS02025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RL_RS02030	COG1396	sequence-specific DNA binding
RL_RS02035	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RL_RS02040	COG1253	flavin adenine dinucleotide binding
RL_RS02045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RL_RS02050	COG1702	phosphate starvation-inducible protein PhoH
RL_RS02055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RL_RS02080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RL_RS02090	COG0180	Tryptophanyl-tRNA synthetase
RL_RS02120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RL_RS02125	COG0280	phosphate acetyltransferase
RL_RS02125	COG0281	malic enzyme
RL_RS02140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RL_RS02145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RL_RS02150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RL_RS02150	COG0116	Belongs to the methyltransferase superfamily
RL_RS02175	COG0776	regulation of translation
RL_RS02190	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RL_RS02195	COG1137	ATPase activity
RL_RS02210	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RL_RS02215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RL_RS02220	COG0840	transmembrane signaling receptor activity
RL_RS02225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS02235	COG0840	transmembrane signaling receptor activity
RL_RS02240	COG0242	peptide deformylase activity
RL_RS02255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RL_RS02260	COG0101	tRNA pseudouridine synthase activity
RL_RS02270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RL_RS02275	COG2171	N-acyltransferase activity
RL_RS02295	COG1032	radical SAM domain protein
RL_RS02300	COG2169	Transcriptional regulator
RL_RS02300	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RL_RS02310	COG1304	FMN binding
RL_RS02315	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RL_RS02320	COG5484	DNA packaging
RL_RS02330	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RL_RS02335	COG3920	Histidine kinase
RL_RS02350	COG1278	Cold shock
RL_RS02355	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RL_RS02360	COG0706	membrane insertase activity
RL_RS02365	COG0594	ribonuclease P activity
RL_RS02370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RL_RS02375	COG0840	transmembrane signaling receptor activity
RL_RS02470	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RL_RS02475	COG1309	transcriptional regulator
RL_RS02485	COG0667	Aldo Keto reductase
RL_RS02500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS02510	COG3938	Belongs to the proline racemase family
RL_RS02515	COG1309	transcriptional regulator
RL_RS02520	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS02540	COG5001	Diguanylate cyclase
RL_RS02540	COG3300	MHYT domain
RL_RS02575	COG1072	(Pantothenic acid kinase))
RL_RS02580	COG0418	dihydroorotase activity
RL_RS02615	COG1309	transcriptional regulator
RL_RS02620	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RL_RS02630	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RL_RS02635	COG0166	Belongs to the GPI family
RL_RS02640	COG0318	PFAM AMP-dependent synthetase and ligase
RL_RS02650	COG3250	beta-galactosidase activity
RL_RS02660	COG1174	glycine betaine transport
RL_RS02665	COG1125	glycine betaine transport
RL_RS02670	COG1174	glycine betaine transport
RL_RS02675	COG1732	Glycine betaine
RL_RS02680	COG0583	DNA-binding transcription factor activity
RL_RS02685	COG3142	Participates in the control of copper homeostasis
RL_RS02690	COG1063	alcohol dehydrogenase
RL_RS02695	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS02720	COG2721	sulfolactate sulfo-lyase activity
RL_RS02730	COG0590	tRNA wobble adenosine to inosine editing
RL_RS02735	COG4178	(ABC) transporter
RL_RS02760	COG2814	Major facilitator Superfamily
RL_RS02795	COG2010	Cytochrome c
RL_RS02810	COG3278	Belongs to the heme-copper respiratory oxidase family
RL_RS02830	COG2326	polyphosphate kinase activity
RL_RS02835	COG5002	protein histidine kinase activity
RL_RS02850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RL_RS02855	COG0573	inorganic phosphate transmembrane transporter activity
RL_RS02865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RL_RS02870	COG0704	Plays a role in the regulation of phosphate uptake
RL_RS02875	COG0745	RESPONSE REGULATOR receiver
RL_RS02885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RL_RS02890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RL_RS02895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
RL_RS02905	COG2967	ApaG domain
RL_RS02915	COG0717	Belongs to the dCTP deaminase family
RL_RS02965	COG0840	transmembrane signaling receptor activity
RL_RS02970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS03005	COG0167	dihydroorotate dehydrogenase activity
RL_RS03010	COG0534	Mate efflux family protein
RL_RS03040	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RL_RS03045	COG1959	2 iron, 2 sulfur cluster binding
RL_RS03055	COG1201	RNA secondary structure unwinding
RL_RS03080	COG0730	response to heat
RL_RS03100	COG1960	acyl-CoA dehydrogenase activity
RL_RS03105	COG0183	Belongs to the thiolase family
RL_RS03115	COG1250	3-hydroxyacyl-CoA dehydrogenase
RL_RS03115	COG1024	Enoyl-CoA hydratase
RL_RS03120	COG1278	Cold shock
RL_RS03150	COG0784	Response regulator, receiver
RL_RS03150	COG2198	Histidine kinase
RL_RS03150	COG2205	protein histidine kinase activity
RL_RS03155	COG1970	mechanosensitive ion channel activity
RL_RS03170	COG5001	Diguanylate cyclase
RL_RS03215	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RL_RS03225	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RL_RS03230	COG5328	Belongs to the UPF0262 family
RL_RS03235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RL_RS03240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RL_RS03245	COG0424	maF-like protein
RL_RS03250	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RL_RS03265	COG1396	sequence-specific DNA binding
RL_RS03275	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS03325	COG1129	ABC transporter
RL_RS03330	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS03345	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS03350	COG3842	ATPase activity
RL_RS03360	COG0395	ABC-type sugar transport system, permease component
RL_RS03365	COG1175	transmembrane transport
RL_RS03375	COG1082	Xylose isomerase domain protein TIM barrel
RL_RS03380	COG1940	carbohydrate kinase activity
RL_RS03385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS03390	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
RL_RS03400	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS03410	COG0673	inositol 2-dehydrogenase activity
RL_RS03430	COG1063	alcohol dehydrogenase
RL_RS03435	COG1609	Transcriptional regulator
RL_RS03445	COG2072	flavoprotein involved in K transport
RL_RS03455	COG0438	transferase activity, transferring glycosyl groups
RL_RS03460	COG2144	transferase activity, transferring acyl groups
RL_RS03540	COG0346	lactoylglutathione lyase activity
RL_RS03545	COG4251	negative regulation of phosphorylation
RL_RS03555	COG4251	negative regulation of phosphorylation
RL_RS03565	COG2197	response regulator
RL_RS03590	COG4651	solute:proton antiporter activity
RL_RS03590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RL_RS03600	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RL_RS03605	COG0840	transmembrane signaling receptor activity
RL_RS03615	COG0745	RESPONSE REGULATOR receiver
RL_RS03620	COG2198	Histidine kinase
RL_RS03620	COG0643	Histidine kinase
RL_RS03625	COG0835	chemotaxis
RL_RS03630	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RL_RS03635	COG2201	protein-glutamate methylesterase activity
RL_RS03640	COG0745	RESPONSE REGULATOR receiver
RL_RS03645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RL_RS03655	COG1766	The M ring may be actively involved in energy transduction
RL_RS03660	COG2771	luxR family
RL_RS03675	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RL_RS03680	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RL_RS03685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RL_RS03690	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RL_RS03695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RL_RS03700	COG4786	Flagellar basal body rod
RL_RS03705	COG1157	protein secretion by the type III secretion system
RL_RS03715	COG1815	bacterial-type flagellum-dependent cell motility
RL_RS03720	COG1558	bacterial-type flagellum-dependent cell motility
RL_RS03725	COG1677	Flagellar hook-basal body complex protein FliE
RL_RS03730	COG4786	Flagellar basal body rod
RL_RS03735	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RL_RS03740	COG1706	bacterial-type flagellum-dependent cell motility
RL_RS03750	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RL_RS03760	COG1338	Plays a role in the flagellum-specific transport system
RL_RS03785	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RL_RS03795	COG1360	Flagellar Motor Protein
RL_RS03820	COG1749	Flagellar hook protein flgE
RL_RS03840	COG5443	negative regulation of bacterial-type flagellum assembly
RL_RS03855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RL_RS03860	COG1684	flagellar biosynthetic protein fliR
RL_RS03885	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RL_RS03895	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RL_RS03900	COG1609	Transcriptional regulator
RL_RS03905	COG1653	transport
RL_RS03910	COG1175	transmembrane transport
RL_RS03915	COG0395	ABC-type sugar transport system, permease component
RL_RS03920	COG0366	Alpha amylase catalytic
RL_RS03925	COG3842	ATPase activity
RL_RS03935	COG0129	dihydroxy-acid dehydratase activity
RL_RS03940	COG0363	glucosamine-6-phosphate deaminase activity
RL_RS03945	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RL_RS03950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS03960	COG2081	HI0933 family
RL_RS03965	COG0840	transmembrane signaling receptor activity
RL_RS03965	COG2972	Histidine kinase
RL_RS03970	COG0840	transmembrane signaling receptor activity
RL_RS03990	COG2224	Isocitrate lyase
RL_RS04000	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RL_RS04005	COG3842	ATPase activity
RL_RS04010	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS04015	COG1177	transmembrane transport
RL_RS04025	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RL_RS04030	COG2205	protein histidine kinase activity
RL_RS04075	COG1959	2 iron, 2 sulfur cluster binding
RL_RS04080	COG0747	negative chemotaxis
RL_RS04085	COG0601	transmembrane transport
RL_RS04090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS04095	COG0444	Belongs to the ABC transporter superfamily
RL_RS04100	COG4608	Belongs to the ABC transporter superfamily
RL_RS04105	COG3265	gluconokinase activity
RL_RS04110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS04115	COG1755	Isoprenylcysteine carboxyl methyltransferase
RL_RS04130	COG1595	DNA-templated transcription, initiation
RL_RS04140	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
RL_RS04150	COG2801	Transposase and inactivated derivatives
RL_RS04160	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RL_RS04165	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RL_RS04190	COG4106	trans-aconitate 2-methyltransferase activity
RL_RS04265	COG0110	maltose O-acetyltransferase activity
RL_RS04305	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RL_RS04320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RL_RS04325	COG2963	transposase activity
RL_RS04370	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RL_RS04410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RL_RS04420	COG0477	Major facilitator Superfamily
RL_RS04425	COG1234	tRNA 3'-trailer cleavage
RL_RS04450	COG0583	DNA-binding transcription factor activity
RL_RS04480	COG0306	phosphate transporter
RL_RS04495	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RL_RS04500	COG4221	oxidoreductase activity
RL_RS04500	COG3321	synthase
RL_RS04500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RL_RS04500	COG0604	alcohol dehydrogenase
RL_RS04510	COG0583	DNA-binding transcription factor activity
RL_RS04515	COG0277	FAD linked oxidase domain protein
RL_RS04520	COG0277	FAD linked oxidase domain protein
RL_RS04525	COG0247	lactate metabolic process
RL_RS04540	COG1388	LysM domain
RL_RS04540	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS04545	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS04550	COG2818	Glycosylase
RL_RS04570	COG0667	Aldo Keto reductase
RL_RS04590	COG0124	histidyl-tRNA synthetase
RL_RS04595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RL_RS04600	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RL_RS04605	COG2259	Doxx family
RL_RS04610	COG0625	glutathione transferase activity
RL_RS04620	COG0459	protein refolding
RL_RS04625	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RL_RS04635	COG0196	riboflavin kinase activity
RL_RS04650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RL_RS04660	COG0590	tRNA wobble adenosine to inosine editing
RL_RS04665	COG1187	pseudouridine synthase activity
RL_RS04670	COG0742	ribosomal rna small subunit methyltransferase
RL_RS04700	COG0312	modulator of DNA gyrase
RL_RS04705	COG0483	inositol monophosphate 1-phosphatase activity
RL_RS04715	COG1519	Transferase
RL_RS04725	COG1663	tetraacyldisaccharide 4'-kinase activity
RL_RS04730	COG1802	Transcriptional regulator
RL_RS04735	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS04755	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RL_RS04765	COG5001	Diguanylate cyclase
RL_RS04765	COG3300	MHYT domain
RL_RS04775	COG3386	PFAM SMP-30 Gluconolaconase
RL_RS04780	COG0800	Aldolase
RL_RS04785	COG3734	2-keto-3-deoxy-galactonokinase
RL_RS04790	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS04795	COG1414	Transcriptional regulator
RL_RS04800	COG2197	response regulator
RL_RS04805	COG0489	protein tyrosine kinase activity
RL_RS04810	COG0598	Magnesium transport protein CorA
RL_RS04815	COG3158	transport of potassium into the cell
RL_RS04830	COG0356	it plays a direct role in the translocation of protons across the membrane
RL_RS04840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RL_RS04845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RL_RS04850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RL_RS04870	COG0521	Mo-molybdopterin cofactor biosynthetic process
RL_RS04875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RL_RS04885	COG0142	geranyltranstransferase activity
RL_RS04900	COG1914	H( )-stimulated, divalent metal cation uptake system
RL_RS04915	COG0752	glycyl-tRNA synthetase alpha subunit
RL_RS04920	COG1704	LemA family
RL_RS04925	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RL_RS04935	COG0151	Belongs to the GarS family
RL_RS04945	COG0840	transmembrane signaling receptor activity
RL_RS04950	COG1683	Conserved Protein
RL_RS04955	COG0751	glycine-tRNA ligase activity
RL_RS04960	COG2183	response to ionizing radiation
RL_RS04965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RL_RS04980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RL_RS05000	COG0009	L-threonylcarbamoyladenylate synthase
RL_RS05010	COG4638	Rieske (2fe-2S)
RL_RS05025	COG1960	acyl-CoA dehydrogenase activity
RL_RS05045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RL_RS05060	COG0840	transmembrane signaling receptor activity
RL_RS05065	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RL_RS05070	COG1741	Belongs to the pirin family
RL_RS05080	COG1722	exodeoxyribonuclease VII activity
RL_RS05085	COG0123	including yeast histone deacetylase and acetoin utilization protein
RL_RS05095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RL_RS05130	COG0765	amino acid transport
RL_RS05140	COG2186	Transcriptional regulator
RL_RS05145	COG1802	Transcriptional regulator
RL_RS05155	COG0318	PFAM AMP-dependent synthetase and ligase
RL_RS05200	COG0596	Alpha beta hydrolase
RL_RS05210	COG1268	BioY protein
RL_RS05215	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RL_RS05220	COG1122	ATPase activity
RL_RS05225	COG3214	Protein conserved in bacteria
RL_RS05230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RL_RS05230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RL_RS05235	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RL_RS05255	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RL_RS05260	COG0484	heat shock protein binding
RL_RS05270	COG0259	pyridoxamine-phosphate oxidase activity
RL_RS05280	COG1686	Belongs to the peptidase S11 family
RL_RS05295	COG0312	modulator of DNA gyrase
RL_RS05305	COG1565	acr, cog1565
RL_RS05305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RL_RS05310	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RL_RS05315	COG0109	protoheme IX farnesyltransferase activity
RL_RS05325	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RL_RS05345	COG3346	SURF1 family
RL_RS05350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RL_RS05355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RL_RS05360	COG0328	RNA-DNA hybrid ribonuclease activity
RL_RS05375	COG1678	Uncharacterized ACR, COG1678
RL_RS05385	COG0678	peroxiredoxin activity
RL_RS05385	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RL_RS05410	COG2072	flavoprotein involved in K transport
RL_RS05415	COG1126	abc transporter atp-binding protein
RL_RS05420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS05425	COG0765	amino acid transport
RL_RS05435	COG1121	(ABC) transporter
RL_RS05440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RL_RS05445	COG0803	Belongs to the bacterial solute-binding protein 9 family
RL_RS05490	COG0018	arginyl-trna synthetase
RL_RS05505	COG0612	Peptidase, M16
RL_RS05520	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RL_RS05525	COG2972	Histidine kinase
RL_RS05525	COG0840	transmembrane signaling receptor activity
RL_RS05580	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RL_RS05595	COG1194	a g-specific adenine glycosylase
RL_RS05610	COG2184	nucleotidyltransferase activity
RL_RS05630	COG1196	nuclear chromosome segregation
RL_RS05635	COG0574	Belongs to the PEP-utilizing enzyme family
RL_RS05635	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RL_RS05710	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RL_RS05715	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RL_RS05725	COG3586	endonuclease activity
RL_RS05915	COG0640	Transcriptional regulator
RL_RS05920	COG3453	Protein conserved in bacteria
RL_RS05920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RL_RS06045	COG2863	cytochrome
RL_RS06050	COG0235	Class ii aldolase
RL_RS06055	COG0784	Response regulator, receiver
RL_RS06055	COG4191	Histidine kinase
RL_RS06075	COG0251	oxidation-reduction process
RL_RS06085	COG0640	Transcriptional regulator
RL_RS06095	COG0740	serine-type endopeptidase activity
RL_RS06130	COG1238	metal cluster binding
RL_RS06165	COG0259	pyridoxamine-phosphate oxidase activity
RL_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS06175	COG0583	DNA-binding transcription factor activity
RL_RS06195	COG0640	Transcriptional regulator
RL_RS06205	COG0640	Transcriptional regulator
RL_RS06210	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS06230	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS06255	COG0583	DNA-binding transcription factor activity
RL_RS06270	COG0702	epimerase
RL_RS06305	COG0625	glutathione transferase activity
RL_RS06315	COG0640	Transcriptional regulator
RL_RS06350	COG0640	Transcriptional regulator
RL_RS06365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RL_RS06390	COG2135	peptidase activity
RL_RS06405	COG0300	oxidoreductase activity
RL_RS06415	COG1309	transcriptional regulator
RL_RS06430	COG3119	arylsulfatase activity
RL_RS06440	COG3119	arylsulfatase activity
RL_RS06535	COG1609	Transcriptional regulator
RL_RS06540	COG0583	DNA-binding transcription factor activity
RL_RS06550	COG0583	DNA-binding transcription factor activity
RL_RS06580	COG0175	sulfate reduction
RL_RS06585	COG0175	sulfate reduction
RL_RS06590	COG1959	2 iron, 2 sulfur cluster binding
RL_RS06600	COG0583	DNA-binding transcription factor activity
RL_RS06625	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RL_RS06630	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS06635	COG1309	transcriptional regulator
RL_RS06650	COG4943	cyclic-guanylate-specific phosphodiesterase activity
RL_RS06685	COG1349	DNA-binding transcription factor activity
RL_RS06710	COG0583	DNA-binding transcription factor activity
RL_RS06715	COG0435	Glutathione S-transferase
RL_RS06730	COG0584	glycerophosphoryl diester phosphodiesterase
RL_RS06735	COG0596	Alpha beta hydrolase
RL_RS06745	COG1793	dna ligase
RL_RS06755	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS06760	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS06765	COG1278	Cold shock
RL_RS06775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RL_RS06785	COG1846	Transcriptional regulator
RL_RS06790	COG1764	response to oxidative stress
RL_RS06820	COG0488	(ABC) transporter
RL_RS06835	COG0488	(ABC) transporter
RL_RS06840	COG0433	COG0433 Predicted ATPase
RL_RS06860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RL_RS06865	COG4106	trans-aconitate 2-methyltransferase activity
RL_RS06870	COG1253	flavin adenine dinucleotide binding
RL_RS06875	COG0840	transmembrane signaling receptor activity
RL_RS06890	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RL_RS06910	COG1064	alcohol dehydrogenase
RL_RS06915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RL_RS06925	COG0583	DNA-binding transcription factor activity
RL_RS06945	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RL_RS06950	COG0625	glutathione transferase activity
RL_RS06970	COG0730	response to heat
RL_RS06985	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RL_RS06995	COG2207	Transcriptional regulator
RL_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS07010	COG1280	lysine exporter protein (LysE YggA)
RL_RS07020	COG2010	Cytochrome c
RL_RS07055	COG4993	Dehydrogenase
RL_RS07060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RL_RS07065	COG0477	Major facilitator Superfamily
RL_RS07115	COG2514	catechol 2,3-dioxygenase activity
RL_RS07125	COG1272	protein, Hemolysin III
RL_RS07130	COG1247	-acetyltransferase
RL_RS07140	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RL_RS07150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RL_RS07150	COG2111	Na H antiporter
RL_RS07155	COG2111	Na H antiporter
RL_RS07160	COG1006	Multisubunit Na H antiporter MnhC subunit
RL_RS07165	COG0651	ATP synthesis coupled electron transport
RL_RS07170	COG1863	multisubunit Na H antiporter MnhE subunit
RL_RS07175	COG2212	antiporter activity
RL_RS07180	COG1320	monovalent cation:proton antiporter activity
RL_RS07185	COG4957	zinc ion binding
RL_RS07190	COG2166	iron-sulfur cluster assembly
RL_RS07200	COG2205	protein histidine kinase activity
RL_RS07210	COG2207	Transcriptional regulator
RL_RS07220	COG0840	transmembrane signaling receptor activity
RL_RS07250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RL_RS07255	COG2983	Belongs to the UPF0260 family
RL_RS07280	COG4221	oxidoreductase activity
RL_RS07285	COG3239	Fatty acid desaturase
RL_RS07305	COG0583	DNA-binding transcription factor activity
RL_RS07340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RL_RS07345	COG0459	protein refolding
RL_RS07355	COG0673	inositol 2-dehydrogenase activity
RL_RS07365	COG1082	Xylose isomerase domain protein TIM barrel
RL_RS07375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RL_RS07390	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RL_RS07405	COG0625	glutathione transferase activity
RL_RS07420	COG1309	transcriptional regulator
RL_RS07460	COG4235	cytochrome complex assembly
RL_RS07465	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RL_RS07470	COG1138	Cytochrome C-type biogenesis protein
RL_RS07475	COG3088	subunit of a heme lyase
RL_RS07480	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RL_RS07485	COG0745	RESPONSE REGULATOR receiver
RL_RS07490	COG2205	protein histidine kinase activity
RL_RS07495	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RL_RS07505	COG2205	protein histidine kinase activity
RL_RS07505	COG2202	Pas domain
RL_RS07510	COG0308	aminopeptidase N
RL_RS07515	COG0840	transmembrane signaling receptor activity
RL_RS07515	COG3290	protein histidine kinase activity
RL_RS07540	COG0443	Heat shock 70 kDa protein
RL_RS07560	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS07570	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS07585	COG2239	Acts as a magnesium transporter
RL_RS07595	COG1733	regulation of RNA biosynthetic process
RL_RS07600	COG2814	Major facilitator Superfamily
RL_RS07610	COG0174	glutamine synthetase
RL_RS07620	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RL_RS07625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RL_RS07630	COG0463	Glycosyl transferase, family 2
RL_RS07635	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RL_RS07645	COG4941	Belongs to the sigma-70 factor family
RL_RS07655	COG3795	YCII-related domain
RL_RS07660	COG3795	YCII-related domain
RL_RS07670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RL_RS07695	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RL_RS07750	COG3718	enzyme involved in inositol metabolism
RL_RS07765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS07775	COG0673	inositol 2-dehydrogenase activity
RL_RS07805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS07810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RL_RS07820	COG1758	RNA polymerase activity
RL_RS07835	COG0736	holo-[acyl-carrier-protein] synthase activity
RL_RS07840	COG0681	Belongs to the peptidase S26 family
RL_RS07845	COG0571	ribonuclease III activity
RL_RS07850	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RL_RS07855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RL_RS07865	COG1381	Involved in DNA repair and RecF pathway recombination
RL_RS07870	COG0656	L-ascorbic acid biosynthetic process
RL_RS07880	COG1418	mRNA catabolic process
RL_RS07885	COG3300	MHYT domain
RL_RS07885	COG5001	Diguanylate cyclase
RL_RS07895	COG2032	superoxide dismutase activity
RL_RS07900	COG0668	transmembrane transport
RL_RS07910	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RL_RS07915	COG0354	folic acid binding
RL_RS07935	COG1051	belongs to the nudix hydrolase family
RL_RS07940	COG1742	UPF0060 membrane protein
RL_RS07950	COG1183	phosphatidylcholine synthase activity
RL_RS07955	COG0688	phosphatidylethanolamine metabolic process
RL_RS07960	COG5265	(ABC) transporter
RL_RS07980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RL_RS08005	COG0215	cysteine-tRNA ligase activity
RL_RS08015	COG4221	oxidoreductase activity
RL_RS08020	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RL_RS08025	COG1286	toxin biosynthetic process
RL_RS08035	COG1280	lysine exporter protein (LysE YggA)
RL_RS08040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RL_RS08045	COG0305	Participates in initiation and elongation during chromosome replication
RL_RS08050	COG0359	binds to the 23S rRNA
RL_RS08060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RL_RS08065	COG0360	Binds together with S18 to 16S ribosomal RNA
RL_RS08070	COG0667	Aldo Keto reductase
RL_RS08075	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RL_RS08085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RL_RS08090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RL_RS08095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RL_RS08100	COG1561	YicC-like family, N-terminal region
RL_RS08105	COG0194	GDP metabolic process
RL_RS08110	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RL_RS08115	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RL_RS08125	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RL_RS08140	COG0671	phosphoesterase, PA-phosphatase related
RL_RS08145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RL_RS08165	COG1505	serine-type exopeptidase activity
RL_RS08170	COG0488	(ABC) transporter
RL_RS08190	COG0105	UTP biosynthetic process
RL_RS08210	COG0314	molybdopterin synthase activity
RL_RS08220	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RL_RS08225	COG0322	excinuclease ABC activity
RL_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS08245	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RL_RS08250	COG0243	molybdopterin cofactor binding
RL_RS08260	COG3454	Phosphonate metabolism
RL_RS08265	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RL_RS08270	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RL_RS08275	COG0628	permease
RL_RS08285	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RL_RS08300	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RL_RS08305	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RL_RS08310	COG2132	Multicopper oxidase
RL_RS08315	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RL_RS08325	COG1309	transcriptional regulator
RL_RS08335	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RL_RS08350	COG2336	PFAM SpoVT AbrB
RL_RS08360	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RL_RS08370	COG0113	porphobilinogen synthase activity
RL_RS08395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RL_RS08400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RL_RS08405	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RL_RS08405	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RL_RS08415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RL_RS08420	COG1091	dTDP-4-dehydrorhamnose reductase activity
RL_RS08425	COG1088	dTDP-glucose 4,6-dehydratase activity
RL_RS08430	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RL_RS08460	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RL_RS08465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RL_RS08470	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RL_RS08490	COG0416	fatty acid biosynthetic process
RL_RS08495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RL_RS08500	COG0776	regulation of translation
RL_RS08540	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
RL_RS08550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RL_RS08560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RL_RS08590	COG1940	carbohydrate kinase activity
RL_RS08605	COG1175	transmembrane transport
RL_RS08610	COG0395	ABC-type sugar transport system, permease component
RL_RS08625	COG0297	glycogen (starch) synthase activity
RL_RS08650	COG1612	heme a metabolic process
RL_RS08660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RL_RS08665	COG0010	Belongs to the arginase family
RL_RS08675	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RL_RS08680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RL_RS08695	COG1024	Enoyl-CoA hydratase
RL_RS08710	COG1832	CoA-binding protein
RL_RS08725	COG5001	Diguanylate cyclase
RL_RS08730	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RL_RS08740	COG0581	inorganic phosphate transmembrane transporter activity
RL_RS08745	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RL_RS08750	COG2124	cytochrome p450
RL_RS08755	COG3706	GGDEF domain
RL_RS08760	COG0740	serine-type endopeptidase activity
RL_RS08765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RL_RS08770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RL_RS08775	COG0776	regulation of translation
RL_RS08780	COG0697	spore germination
RL_RS08790	COG0667	Aldo Keto reductase
RL_RS08810	COG0386	Belongs to the glutathione peroxidase family
RL_RS08840	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RL_RS08845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RL_RS08850	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RL_RS08855	COG0649	NAD binding
RL_RS08865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
RL_RS08870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RL_RS08875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RL_RS08875	COG3743	rRNA binding
RL_RS08885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RL_RS08890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RL_RS08915	COG1007	ATP synthesis coupled electron transport
RL_RS08920	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RL_RS08920	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RL_RS08930	COG0346	lactoylglutathione lyase activity
RL_RS08940	COG0442	prolyl-tRNA aminoacylation
RL_RS08950	COG1136	(ABC) transporter
RL_RS08975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RL_RS08995	COG0784	Response regulator, receiver
RL_RS09005	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RL_RS09010	COG0477	Major facilitator Superfamily
RL_RS09020	COG0557	exoribonuclease II activity
RL_RS09025	COG1754	DNA topoisomerase type I activity
RL_RS09025	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RL_RS09030	COG0758	DNA mediated transformation
RL_RS09035	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RL_RS09045	COG0540	Belongs to the ATCase OTCase family
RL_RS09050	COG1960	acyl-CoA dehydrogenase activity
RL_RS09055	COG1530	ribonuclease E activity
RL_RS09060	COG0860	N-Acetylmuramoyl-L-alanine amidase
RL_RS09065	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RL_RS09075	COG1129	ABC transporter
RL_RS09080	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS09085	COG1879	ABC-type sugar transport system periplasmic component
RL_RS09090	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS09095	COG2376	Dihydroxyacetone kinase
RL_RS09110	COG2376	Dihydroxyacetone kinase
RL_RS09115	COG1461	Dihydroxyacetone kinase
RL_RS09130	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RL_RS09145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RL_RS09160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RL_RS09165	COG1086	Polysaccharide biosynthesis protein
RL_RS09175	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RL_RS09185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RL_RS09190	COG0081	regulation of translation
RL_RS09195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RL_RS09200	COG0222	ribosome binding
RL_RS09205	COG0085	RNA polymerase activity
RL_RS09210	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RL_RS09220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RL_RS09225	COG0049	tRNA binding
RL_RS09230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RL_RS09235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RL_RS09240	COG0051	transcription antitermination factor activity, RNA binding
RL_RS09245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RL_RS09250	COG0088	Forms part of the polypeptide exit tunnel
RL_RS09255	COG0089	rRNA binding
RL_RS09260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RL_RS09265	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RL_RS09270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RL_RS09275	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RL_RS09280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RL_RS09285	COG0255	Belongs to the universal ribosomal protein uL29 family
RL_RS09290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RL_RS09295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RL_RS09300	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RL_RS09305	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RL_RS09310	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RL_RS09315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RL_RS09320	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RL_RS09325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RL_RS09330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RL_RS09335	COG1841	ribosomal large subunit assembly
RL_RS09340	COG0200	Binds to the 23S rRNA
RL_RS09345	COG0201	protein transport
RL_RS09350	COG0563	adenylate kinase activity
RL_RS09355	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RL_RS09360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RL_RS09365	COG0202	RNA polymerase activity
RL_RS09370	COG0203	ribosomal protein L17
RL_RS09380	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RL_RS09385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RL_RS09390	COG0129	dihydroxy-acid dehydratase activity
RL_RS09410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RL_RS09430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS09435	COG0596	Alpha beta hydrolase
RL_RS09435	COG0508	dehydrogenase complex catalyzes the overall conversion of
RL_RS09440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RL_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS09450	COG0583	DNA-binding transcription factor activity
RL_RS09470	COG5002	protein histidine kinase activity
RL_RS09480	COG1609	Transcriptional regulator
RL_RS09490	COG1024	Enoyl-CoA hydratase
RL_RS09495	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS09500	COG1653	transport
RL_RS09505	COG1175	transmembrane transport
RL_RS09510	COG0395	ABC-type sugar transport system, permease component
RL_RS09515	COG3842	ATPase activity
RL_RS09530	COG0673	inositol 2-dehydrogenase activity
RL_RS09535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RL_RS09560	COG2197	response regulator
RL_RS09575	COG2226	methyltransferase
RL_RS09615	COG4566	intracellular signal transduction
RL_RS09625	COG0596	Alpha beta hydrolase
RL_RS09635	COG1335	isochorismatase
RL_RS09690	COG1522	sequence-specific DNA binding
RL_RS09695	COG1522	sequence-specific DNA binding
RL_RS09705	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RL_RS09715	COG0625	glutathione transferase activity
RL_RS09740	COG2217	Heavy metal translocating P-type atpase
RL_RS09775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RL_RS09790	COG4191	Histidine kinase
RL_RS09790	COG0784	Response regulator, receiver
RL_RS09795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RL_RS09810	COG0071	Belongs to the small heat shock protein (HSP20) family
RL_RS09820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RL_RS09830	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RL_RS09845	COG2132	Multicopper oxidase
RL_RS09930	COG0668	transmembrane transport
RL_RS09940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RL_RS09945	COG3119	arylsulfatase activity
RL_RS09955	COG2304	oxidoreductase activity
RL_RS09975	COG0714	Associated with various cellular activities
RL_RS09980	COG3119	arylsulfatase activity
RL_RS10025	COG3468	outer membrane autotransporter barrel domain protein
RL_RS10040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RL_RS10075	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RL_RS10110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RL_RS10120	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RL_RS10130	COG1546	Belongs to the CinA family
RL_RS10130	COG1058	Belongs to the CinA family
RL_RS10135	COG0655	NAD(P)H dehydrogenase (quinone) activity
RL_RS10150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RL_RS10170	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS10180	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
RL_RS10185	COG0583	DNA-binding transcription factor activity
RL_RS10190	COG0737	Belongs to the 5'-nucleotidase family
RL_RS10210	COG1522	sequence-specific DNA binding
RL_RS10215	COG0686	Belongs to the AlaDH PNT family
RL_RS10225	COG4221	oxidoreductase activity
RL_RS10250	COG4106	trans-aconitate 2-methyltransferase activity
RL_RS10260	COG2897	thiosulfate sulfurtransferase activity
RL_RS10270	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RL_RS10275	COG3806	Anti-sigma factor
RL_RS10280	COG0300	oxidoreductase activity
RL_RS10285	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RL_RS10300	COG0415	Belongs to the DNA photolyase family
RL_RS10315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RL_RS10320	COG0243	molybdopterin cofactor binding
RL_RS10330	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RL_RS10340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RL_RS10345	COG3707	response regulator
RL_RS10350	COG1609	Transcriptional regulator
RL_RS10355	COG1879	ABC-type sugar transport system periplasmic component
RL_RS10360	COG1129	ABC transporter
RL_RS10365	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS10370	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS10375	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RL_RS10375	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RL_RS10380	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RL_RS10395	COG0450	alkyl hydroperoxide reductase
RL_RS10400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RL_RS10405	COG0625	glutathione transferase activity
RL_RS10430	COG3842	ATPase activity
RL_RS10435	COG1177	transmembrane transport
RL_RS10440	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS10450	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RL_RS10475	COG1120	ATPase activity
RL_RS10495	COG0753	catalase activity
RL_RS10550	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RL_RS10560	COG0525	valine-tRNA ligase activity
RL_RS10585	COG0316	Belongs to the HesB IscA family
RL_RS10590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RL_RS10595	COG0018	arginyl-trna synthetase
RL_RS10605	COG1472	Belongs to the glycosyl hydrolase 3 family
RL_RS10610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RL_RS10615	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RL_RS10620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RL_RS10625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RL_RS10630	COG0805	protein transport
RL_RS10635	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RL_RS10640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RL_RS10645	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RL_RS10660	COG1862	Preprotein translocase
RL_RS10685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RL_RS10705	COG0544	peptidyl-prolyl cis-trans isomerase activity
RL_RS10715	COG1032	radical SAM domain protein
RL_RS10735	COG2003	Belongs to the UPF0758 family
RL_RS10740	COG0024	Methionine aminopeptidase
RL_RS10760	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RL_RS10765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RL_RS10770	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RL_RS10775	COG0154	amidase activity
RL_RS10780	COG1247	-acetyltransferase
RL_RS10790	COG3811	Belongs to the UPF0386 family
RL_RS10805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RL_RS10825	COG4765	Protein conserved in bacteria
RL_RS10830	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RL_RS10840	COG0511	ligase activity, forming carbon-carbon bonds
RL_RS10845	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RL_RS10855	COG0436	Aminotransferase
RL_RS10865	COG3243	poly(R)-hydroxyalkanoic acid synthase
RL_RS10875	COG0436	Aminotransferase
RL_RS10890	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RL_RS10920	COG1278	Cold shock
RL_RS10975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RL_RS11085	COG3436	PFAM IS66 Orf2 family protein
RL_RS11090	COG2433	Pfam Transposase IS66
RL_RS11110	COG4372	Transposase
RL_RS11295	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RL_RS11335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RL_RS11410	COG1126	abc transporter atp-binding protein
RL_RS11415	COG0765	amino acid transport
RL_RS11420	COG4597	amino acid ABC transporter
RL_RS11425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS11430	COG0626	cystathionine gamma-synthase activity
RL_RS11445	COG2267	carboxylic ester hydrolase activity
RL_RS11465	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RL_RS11480	COG0537	adenosine 5'-monophosphoramidase activity
RL_RS11505	COG0052	Belongs to the universal ribosomal protein uS2 family
RL_RS11510	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RL_RS11515	COG0528	UMP kinase activity
RL_RS11520	COG0233	cytoplasmic translational termination
RL_RS11525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RL_RS11535	COG0750	zinc metalloprotease
RL_RS11540	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RL_RS11545	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RL_RS11550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RL_RS11555	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RL_RS11560	COG3494	Protein of unknown function (DUF1009)
RL_RS11565	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RL_RS11575	COG0658	competence protein
RL_RS11575	COG2333	competence protein COMEC
RL_RS11580	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RL_RS11590	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RL_RS11595	COG0148	phosphopyruvate hydratase activity
RL_RS11605	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RL_RS11610	COG0508	dehydrogenase complex catalyzes the overall conversion of
RL_RS11610	COG0022	dehydrogenase e1 component
RL_RS11615	COG0508	dehydrogenase complex catalyzes the overall conversion of
RL_RS11630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RL_RS11645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RL_RS11660	COG2867	negative regulation of translational initiation
RL_RS11665	COG1546	Belongs to the CinA family
RL_RS11665	COG1058	Belongs to the CinA family
RL_RS11670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RL_RS11670	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RL_RS11685	COG2204	response regulator
RL_RS11725	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RL_RS11730	COG3119	arylsulfatase activity
RL_RS11755	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RL_RS11760	COG1477	protein flavinylation
RL_RS11795	COG0667	Aldo Keto reductase
RL_RS11800	COG5000	phosphorelay sensor kinase activity
RL_RS11805	COG2204	response regulator
RL_RS11810	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RL_RS11815	COG1923	regulation of RNA biosynthetic process
RL_RS11820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RL_RS11825	COG3956	TIGRFAM MazG family protein
RL_RS11835	COG1648	precorrin-2 dehydrogenase activity
RL_RS11835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RL_RS11845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RL_RS11855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RL_RS11860	COG0679	Auxin Efflux Carrier
RL_RS11865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RL_RS11870	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS11900	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS11905	COG0785	Cytochrome C biogenesis protein
RL_RS11930	COG3237	CsbD-like
RL_RS12005	COG1653	transport
RL_RS12010	COG1175	transmembrane transport
RL_RS12015	COG0395	ABC-type sugar transport system, permease component
RL_RS12020	COG3842	ATPase activity
RL_RS12030	COG2433	Pfam Transposase IS66
RL_RS12035	COG1073	alpha beta
RL_RS12055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS12065	COG2186	Transcriptional regulator
RL_RS12075	COG0601	transmembrane transport
RL_RS12080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS12085	COG0444	Belongs to the ABC transporter superfamily
RL_RS12090	COG4608	Belongs to the ABC transporter superfamily
RL_RS12110	COG1175	transmembrane transport
RL_RS12115	COG0395	ABC-type sugar transport system, permease component
RL_RS12145	COG0583	DNA-binding transcription factor activity
RL_RS12160	COG0667	Aldo Keto reductase
RL_RS12170	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
RL_RS12200	COG1566	PFAM secretion protein HlyD family protein
RL_RS12205	COG0577	efflux transmembrane transporter activity
RL_RS12205	COG1136	(ABC) transporter
RL_RS12210	COG0577	efflux transmembrane transporter activity
RL_RS12210	COG1136	(ABC) transporter
RL_RS12230	COG1183	phosphatidylcholine synthase activity
RL_RS12240	COG3845	ABC transporter
RL_RS12250	COG1079	Belongs to the binding-protein-dependent transport system permease family
RL_RS12260	COG1879	ABC-type sugar transport system periplasmic component
RL_RS12265	COG1129	ABC transporter
RL_RS12270	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS12275	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS12280	COG2186	Transcriptional regulator
RL_RS12285	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RL_RS12290	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RL_RS12300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RL_RS12310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RL_RS12325	COG4166	transmembrane transport
RL_RS12340	COG0174	glutamine synthetase
RL_RS12345	COG0347	Belongs to the P(II) protein family
RL_RS12350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RL_RS12350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RL_RS12355	COG2354	Protein conserved in bacteria
RL_RS12370	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RL_RS12375	COG0629	single-stranded DNA binding
RL_RS12380	COG2095	MarC family integral membrane protein
RL_RS12385	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RL_RS12395	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RL_RS12410	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RL_RS12415	COG0343	queuine tRNA-ribosyltransferase activity
RL_RS12425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RL_RS12475	COG1175	transmembrane transport
RL_RS12490	COG1609	Transcriptional regulator
RL_RS12495	COG0612	Peptidase, M16
RL_RS12520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RL_RS12595	COG0028	Belongs to the TPP enzyme family
RL_RS12605	COG4336	lyase activity
RL_RS12610	COG2814	Major facilitator Superfamily
RL_RS12620	COG1609	Transcriptional regulator
RL_RS12630	COG1129	ABC transporter
RL_RS12635	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS12640	COG2801	Transposase and inactivated derivatives
RL_RS12645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RL_RS12655	COG0668	transmembrane transport
RL_RS12660	COG0596	Alpha beta hydrolase
RL_RS12675	COG0583	DNA-binding transcription factor activity
RL_RS12685	COG1984	allophanate hydrolase subunit 2
RL_RS12690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RL_RS12695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RL_RS12710	COG3174	membrane
RL_RS12725	COG0861	Integral membrane protein TerC family
RL_RS12730	COG0321	lipoyl(octanoyl) transferase activity
RL_RS12730	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RL_RS12735	COG0084	hydrolase, TatD family'
RL_RS12740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RL_RS12745	COG0730	response to heat
RL_RS12755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RL_RS12800	COG2814	Major facilitator Superfamily
RL_RS12810	COG2824	Alkylphosphonate utilization operon protein PhnA
RL_RS12845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RL_RS12850	COG0134	indole-3-glycerol-phosphate synthase activity
RL_RS12855	COG0315	cyclic pyranopterin monophosphate synthase activity
RL_RS12870	COG3474	cytochrome
RL_RS12890	COG1902	pentaerythritol trinitrate reductase activity
RL_RS12895	COG4221	oxidoreductase activity
RL_RS12900	COG2153	protein acetylation
RL_RS12905	COG0513	Belongs to the DEAD box helicase family
RL_RS12920	COG0372	Belongs to the citrate synthase family
RL_RS12925	COG0372	Belongs to the citrate synthase family
RL_RS12935	COG0504	CTP synthase activity
RL_RS12945	COG0149	triose-phosphate isomerase activity
RL_RS12955	COG0187	DNA topoisomerase II activity
RL_RS12960	COG0583	DNA-binding transcription factor activity
RL_RS12980	COG0628	permease
RL_RS13000	COG3077	Addiction module antitoxin, RelB DinJ family
RL_RS13025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RL_RS13035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RL_RS13045	COG0302	gtp cyclohydrolase
RL_RS13050	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RL_RS13055	COG1752	Esterase of the alpha-beta hydrolase superfamily
RL_RS13080	COG2267	carboxylic ester hydrolase activity
RL_RS13095	COG1686	Belongs to the peptidase S11 family
RL_RS13110	COG1760	l-serine dehydratase
RL_RS13125	COG0698	ribose 5-phosphate isomerase
RL_RS13145	COG2239	Acts as a magnesium transporter
RL_RS13150	COG0242	peptide deformylase activity
RL_RS13165	COG0321	lipoyl(octanoyl) transferase activity
RL_RS13185	COG4770	biotin carboxylase activity
RL_RS13195	COG1671	Belongs to the UPF0178 family
RL_RS13205	COG2259	Doxx family
RL_RS13210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RL_RS13225	COG0546	phosphoglycolate phosphatase activity
RL_RS13235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RL_RS13260	COG0509	glycine decarboxylation via glycine cleavage system
RL_RS13265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RL_RS13265	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RL_RS13280	COG0316	Belongs to the HesB IscA family
RL_RS13285	COG2151	metal-sulfur cluster biosynthetic enzyme
RL_RS13290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RL_RS13295	COG0719	Fe-S assembly protein
RL_RS13300	COG0396	ATPase activity
RL_RS13310	COG0719	Fe-S assembly protein
RL_RS13315	COG1104	cysteine desulfurase activity
RL_RS13320	COG2945	thiolester hydrolase activity
RL_RS13335	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RL_RS13340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RL_RS13355	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RL_RS13360	COG2833	Protein of unknown function (DUF455)
RL_RS13365	COG0741	lytic transglycosylase activity
RL_RS13365	COG0739	heme binding
RL_RS13365	COG1196	nuclear chromosome segregation
RL_RS13385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RL_RS13410	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RL_RS13440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RL_RS13445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RL_RS13450	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RL_RS13455	COG0047	phosphoribosylformylglycinamidine synthase activity
RL_RS13470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RL_RS13480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RL_RS13510	COG2814	Major facilitator Superfamily
RL_RS13515	COG2814	Major facilitator Superfamily
RL_RS13530	COG0483	inositol monophosphate 1-phosphatase activity
RL_RS13535	COG0483	inositol monophosphate 1-phosphatase activity
RL_RS13540	COG0037	tRNA processing
RL_RS13545	COG2066	Belongs to the glutaminase family
RL_RS13550	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RL_RS13560	COG2223	nitrite transmembrane transporter activity
RL_RS13565	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RL_RS13570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
RL_RS13585	COG0538	isocitrate dehydrogenase activity
RL_RS13590	COG0456	acetyltransferase
RL_RS13605	COG1280	lysine exporter protein (LysE YggA)
RL_RS13610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RL_RS13615	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RL_RS13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS13625	COG2313	pseudouridylate synthase activity
RL_RS13655	COG3106	COG3106 Predicted ATPase
RL_RS13660	COG3768	UPF0283 membrane protein
RL_RS13670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RL_RS13680	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RL_RS13690	COG0633	Ferredoxin
RL_RS13710	COG1686	Belongs to the peptidase S11 family
RL_RS13730	COG1127	ABC transporter
RL_RS13740	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS13745	COG2814	Major facilitator Superfamily
RL_RS13765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS13770	COG1309	transcriptional regulator
RL_RS13780	COG0583	DNA-binding transcription factor activity
RL_RS13790	COG0280	phosphate acetyltransferase
RL_RS13790	COG0281	malic enzyme
RL_RS13795	COG0328	RNA-DNA hybrid ribonuclease activity
RL_RS13805	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS13815	COG0582	viral genome integration into host DNA
RL_RS13835	COG0517	IMP dehydrogenase activity
RL_RS13840	COG4974	Belongs to the 'phage' integrase family
RL_RS13845	COG0778	Nitroreductase
RL_RS13850	COG0477	Major facilitator Superfamily
RL_RS13855	COG0840	transmembrane signaling receptor activity
RL_RS13870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RL_RS13875	COG0823	Involved in the tonB-independent uptake of proteins
RL_RS13900	COG1132	(ABC) transporter
RL_RS13905	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RL_RS13925	COG1254	Belongs to the acylphosphatase family
RL_RS13935	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RL_RS13940	COG0546	phosphoglycolate phosphatase activity
RL_RS13945	COG2989	Protein conserved in bacteria
RL_RS13950	COG0114	fumarate hydratase activity
RL_RS13960	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RL_RS13960	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RL_RS13970	COG3706	GGDEF domain
RL_RS13985	COG1846	Transcriptional regulator
RL_RS14000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RL_RS14005	COG2226	methyltransferase
RL_RS14015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RL_RS14020	COG1120	ATPase activity
RL_RS14025	COG2390	Transcriptional regulator
RL_RS14030	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RL_RS14035	COG3958	Transketolase
RL_RS14040	COG3959	Transketolase, thiamine diphosphate binding domain
RL_RS14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS14050	COG1879	ABC-type sugar transport system periplasmic component
RL_RS14055	COG1129	ABC transporter
RL_RS14060	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS14070	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS14075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RL_RS14080	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS14090	COG0746	molybdenum cofactor guanylyltransferase activity
RL_RS14095	COG1763	Mo-molybdopterin cofactor biosynthetic process
RL_RS14105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
RL_RS14120	COG0667	Aldo Keto reductase
RL_RS14130	COG1764	response to oxidative stress
RL_RS14135	COG2205	protein histidine kinase activity
RL_RS14155	COG0596	Alpha beta hydrolase
RL_RS14160	COG1349	DNA-binding transcription factor activity
RL_RS14165	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RL_RS14170	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS14180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS14185	COG1175	transmembrane transport
RL_RS14190	COG0395	ABC-type sugar transport system, permease component
RL_RS14200	COG3842	ATPase activity
RL_RS14210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS14225	COG5425	PFAM Usg family protein
RL_RS14240	COG0625	glutathione transferase activity
RL_RS14280	COG1116	anion transmembrane transporter activity
RL_RS14285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RL_RS14290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RL_RS14300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RL_RS14310	COG2084	Dehydrogenase
RL_RS14320	COG0583	DNA-binding transcription factor activity
RL_RS14330	COG1522	sequence-specific DNA binding
RL_RS14335	COG1573	uracil-dna glycosylase
RL_RS14345	COG2205	protein histidine kinase activity
RL_RS14345	COG2202	Pas domain
RL_RS14355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RL_RS14360	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RL_RS14385	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS14390	COG0842	Transport permease protein
RL_RS14395	COG1131	(ABC) transporter
RL_RS14400	COG3507	Belongs to the glycosyl hydrolase 43 family
RL_RS14405	COG0667	Aldo Keto reductase
RL_RS14410	COG0673	inositol 2-dehydrogenase activity
RL_RS14430	COG0395	ABC-type sugar transport system, permease component
RL_RS14435	COG1175	transmembrane transport
RL_RS14450	COG0495	leucyl-tRNA aminoacylation
RL_RS14455	COG0583	DNA-binding transcription factor activity
RL_RS14485	COG1247	-acetyltransferase
RL_RS14495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RL_RS14530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RL_RS14540	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RL_RS14545	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RL_RS14645	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS14650	COG1492	cobalamin metabolic process
RL_RS14670	COG0583	DNA-binding transcription factor activity
RL_RS14705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RL_RS14715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RL_RS14725	COG3618	amidohydrolase
RL_RS14735	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RL_RS14745	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RL_RS14755	COG0583	DNA-binding transcription factor activity
RL_RS14765	COG0583	DNA-binding transcription factor activity
RL_RS14775	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RL_RS14865	COG0668	transmembrane transport
RL_RS14895	COG0745	RESPONSE REGULATOR receiver
RL_RS14915	COG0640	Transcriptional regulator
RL_RS14930	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RL_RS14940	COG0431	NADPH-dependent FMN reductase
RL_RS14955	COG3264	Mechanosensitive ion channel
RL_RS14955	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RL_RS14965	COG0745	RESPONSE REGULATOR receiver
RL_RS14970	COG2814	Major facilitator Superfamily
RL_RS14980	COG1175	transmembrane transport
RL_RS14985	COG0395	ABC-type sugar transport system, permease component
RL_RS15000	COG3842	ATPase activity
RL_RS15010	COG1461	Dihydroxyacetone kinase
RL_RS15035	COG2376	Dihydroxyacetone kinase
RL_RS15050	COG2249	NAD(P)H dehydrogenase (quinone) activity
RL_RS15060	COG0596	Alpha beta hydrolase
RL_RS15070	COG2186	Transcriptional regulator
RL_RS15090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS15095	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RL_RS15100	COG0765	amino acid transport
RL_RS15110	COG1126	abc transporter atp-binding protein
RL_RS15115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS15125	COG1846	Transcriptional regulator
RL_RS15140	COG1764	response to oxidative stress
RL_RS15145	COG2226	methyltransferase
RL_RS15165	COG1607	acyl-coa hydrolase
RL_RS15195	COG2814	Major facilitator Superfamily
RL_RS15210	COG4221	oxidoreductase activity
RL_RS15215	COG0702	epimerase
RL_RS15225	COG0659	secondary active sulfate transmembrane transporter activity
RL_RS15285	COG3387	PFAM Glycoside hydrolase 15-related
RL_RS15290	COG0556	nucleotide-excision repair
RL_RS15305	COG0456	acetyltransferase
RL_RS15330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RL_RS15335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RL_RS15365	COG2205	protein histidine kinase activity
RL_RS15375	COG0431	NADPH-dependent FMN reductase
RL_RS15380	COG1129	ABC transporter
RL_RS15380	COG0842	Transport permease protein
RL_RS15420	COG0667	Aldo Keto reductase
RL_RS15435	COG1522	sequence-specific DNA binding
RL_RS15440	COG0137	argininosuccinate synthase activity
RL_RS15450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RL_RS15465	COG0625	glutathione transferase activity
RL_RS15470	COG1132	(ABC) transporter
RL_RS15510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RL_RS15520	COG0456	acetyltransferase
RL_RS15520	COG0454	-acetyltransferase
RL_RS15555	COG0738	Major facilitator superfamily
RL_RS15565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RL_RS15570	COG3158	transport of potassium into the cell
RL_RS15575	COG0025	NhaP-type Na H and K H
RL_RS15585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RL_RS15590	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RL_RS15630	COG0697	spore germination
RL_RS15645	COG1136	(ABC) transporter
RL_RS15650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS15655	COG1917	Cupin 2, conserved barrel domain protein
RL_RS15655	COG2207	Transcriptional regulator
RL_RS15685	COG0833	amino acid
RL_RS15710	COG1845	cytochrome c oxidase, subunit III
RL_RS15715	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RL_RS15720	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RL_RS15730	COG1280	lysine exporter protein (LysE YggA)
RL_RS15745	COG1120	ATPase activity
RL_RS15750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RL_RS15770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RL_RS15770	COG3453	Protein conserved in bacteria
RL_RS15780	COG2207	Transcriptional regulator
RL_RS15815	COG2255	four-way junction helicase activity
RL_RS15820	COG0667	Aldo Keto reductase
RL_RS15855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RL_RS15915	COG1309	transcriptional regulator
RL_RS15925	COG0662	Cupin 2, conserved barrel domain protein
RL_RS15930	COG0583	DNA-binding transcription factor activity
RL_RS15935	COG5001	Diguanylate cyclase
RL_RS15935	COG3300	MHYT domain
RL_RS15945	COG2226	methyltransferase
RL_RS16010	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RL_RS16030	COG0395	ABC-type sugar transport system, permease component
RL_RS16045	COG1846	Transcriptional regulator
RL_RS16045	COG1940	carbohydrate kinase activity
RL_RS16070	COG0697	spore germination
RL_RS16075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RL_RS16085	COG2204	response regulator
RL_RS16090	COG5002	protein histidine kinase activity
RL_RS16095	COG0456	acetyltransferase
RL_RS16095	COG1214	PFAM Peptidase M22, glycoprotease
RL_RS16100	COG0625	glutathione transferase activity
RL_RS16135	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RL_RS16140	COG0483	inositol monophosphate 1-phosphatase activity
RL_RS16150	COG3842	ATPase activity
RL_RS16160	COG1175	transmembrane transport
RL_RS16195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RL_RS16205	COG0628	permease
RL_RS16220	COG0583	DNA-binding transcription factor activity
RL_RS16295	COG0583	DNA-binding transcription factor activity
RL_RS16335	COG0179	Fumarylacetoacetate (FAA) hydrolase
RL_RS16370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RL_RS16375	COG1121	(ABC) transporter
RL_RS16385	COG0523	cobalamin synthesis protein
RL_RS16405	COG1253	flavin adenine dinucleotide binding
RL_RS16440	COG0384	phenazine biosynthesis protein PhzF
RL_RS16455	COG3842	ATPase activity
RL_RS16460	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS16475	COG1846	Transcriptional regulator
RL_RS16480	COG0667	Aldo Keto reductase
RL_RS16485	COG5634	Uncharacterized conserved protein (DUF2278)
RL_RS16490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RL_RS16495	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RL_RS16515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RL_RS16540	COG0463	Glycosyl transferase, family 2
RL_RS16545	COG2207	Transcriptional regulator
RL_RS16550	COG1064	alcohol dehydrogenase
RL_RS16560	COG1252	NADH dehydrogenase
RL_RS16565	COG1522	sequence-specific DNA binding
RL_RS16570	COG1794	racemase activity, acting on amino acids and derivatives
RL_RS16575	COG0456	acetyltransferase
RL_RS16575	COG1846	Transcriptional regulator
RL_RS16580	COG1309	transcriptional regulator
RL_RS16585	COG2814	Major facilitator Superfamily
RL_RS16590	COG1733	regulation of RNA biosynthetic process
RL_RS16600	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RL_RS16610	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RL_RS16635	COG0668	transmembrane transport
RL_RS16645	COG1846	Transcriptional regulator
RL_RS16705	COG0656	L-ascorbic acid biosynthetic process
RL_RS16710	COG0440	acetolactate synthase activity
RL_RS16715	COG0028	Belongs to the TPP enzyme family
RL_RS16725	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS16740	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RL_RS16745	COG0560	Phosphoserine phosphatase
RL_RS16765	COG0330	HflC and HflK could
RL_RS16770	COG0330	HflC and HflK could
RL_RS16780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RL_RS16805	COG0277	FAD linked oxidase domain protein
RL_RS16810	COG0667	Aldo Keto reductase
RL_RS16815	COG0583	DNA-binding transcription factor activity
RL_RS16820	COG3180	Ammonia monooxygenase
RL_RS16835	COG2885	chlorophyll binding
RL_RS16840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RL_RS16845	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RL_RS16860	COG2719	SpoVR family
RL_RS16865	COG2718	Belongs to the UPF0229 family
RL_RS16870	COG2766	serine protein kinase
RL_RS16895	COG1335	isochorismatase
RL_RS16925	COG0006	proline dipeptidase activity
RL_RS16930	COG2264	protein methyltransferase activity
RL_RS16935	COG1999	signal sequence binding
RL_RS16940	COG0835	chemotaxis
RL_RS16960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RL_RS16975	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RL_RS16985	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RL_RS16990	COG0849	cell division
RL_RS16995	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RL_RS17000	COG1181	Belongs to the D-alanine--D-alanine ligase family
RL_RS17005	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RL_RS17010	COG0477	Major facilitator Superfamily
RL_RS17020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RL_RS17025	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RL_RS17030	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RL_RS17040	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RL_RS17045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RL_RS17055	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RL_RS17070	COG0275	rRNA processing
RL_RS17075	COG2001	Belongs to the MraZ family
RL_RS17095	COG3023	N-Acetylmuramoyl-L-alanine amidase
RL_RS17100	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RL_RS17110	COG1280	lysine exporter protein (LysE YggA)
RL_RS17135	COG3757	hydrolase, family 25
RL_RS17150	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RL_RS17175	COG0697	spore germination
RL_RS17180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RL_RS17185	COG0028	Belongs to the TPP enzyme family
RL_RS17190	COG0251	oxidation-reduction process
RL_RS17205	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS17210	COG1192	Involved in chromosome partitioning
RL_RS17225	COG0174	glutamine synthetase
RL_RS17255	COG2011	ABC-type metal ion transport system permease component
RL_RS17260	COG3842	ATPase activity
RL_RS17275	COG0673	inositol 2-dehydrogenase activity
RL_RS17280	COG0395	ABC-type sugar transport system, permease component
RL_RS17285	COG1175	transmembrane transport
RL_RS17295	COG2971	BadF BadG BcrA BcrD
RL_RS17300	COG2188	Transcriptional regulator
RL_RS17320	COG4702	Belongs to the UPF0303 family
RL_RS17325	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RL_RS17335	COG0395	ABC-type sugar transport system, permease component
RL_RS17340	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS17350	COG3842	ATPase activity
RL_RS17435	COG2968	Membrane
RL_RS17450	COG0432	Pfam Uncharacterised protein family UPF0047
RL_RS17455	COG5507	3-demethylubiquinone-9 3-methyltransferase
RL_RS17505	COG2207	Transcriptional regulator
RL_RS17505	COG1917	Cupin 2, conserved barrel domain protein
RL_RS17530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RL_RS17540	COG1063	alcohol dehydrogenase
RL_RS17550	COG2226	methyltransferase
RL_RS17560	COG0358	DNA primase activity
RL_RS17575	COG0505	Belongs to the CarA family
RL_RS17585	COG0534	Mate efflux family protein
RL_RS17595	COG0667	Aldo Keto reductase
RL_RS17600	COG2321	neutral zinc metallopeptidase
RL_RS17615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RL_RS17640	COG1301	dicarboxylic acid transport
RL_RS17645	COG4191	Histidine kinase
RL_RS17650	COG2204	response regulator
RL_RS17655	COG1522	sequence-specific DNA binding
RL_RS17660	COG0492	ferredoxin-NADP+ reductase activity
RL_RS17665	COG0583	DNA-binding transcription factor activity
RL_RS17670	COG0640	Transcriptional regulator
RL_RS17675	COG2814	Major facilitator Superfamily
RL_RS17680	COG1902	pentaerythritol trinitrate reductase activity
RL_RS17695	COG0583	DNA-binding transcription factor activity
RL_RS17700	COG0456	acetyltransferase
RL_RS17700	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RL_RS17710	COG0387	Pfam Sodium calcium exchanger
RL_RS17720	COG1442	glycosyl transferase family 8
RL_RS17750	COG2133	pyrroloquinoline quinone binding
RL_RS17765	COG1278	Cold shock
RL_RS17780	COG1733	regulation of RNA biosynthetic process
RL_RS17790	COG0745	RESPONSE REGULATOR receiver
RL_RS17795	COG1846	Transcriptional regulator
RL_RS17810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RL_RS17815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RL_RS17835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RL_RS17845	COG1496	oxidoreductase activity
RL_RS17860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RL_RS17870	COG3300	MHYT domain
RL_RS17870	COG5001	Diguanylate cyclase
RL_RS17875	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RL_RS17880	COG3300	MHYT domain
RL_RS17880	COG5001	Diguanylate cyclase
RL_RS17890	COG0193	aminoacyl-tRNA hydrolase activity
RL_RS17900	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RL_RS17935	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RL_RS17940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RL_RS17940	COG2857	Cytochrome c1
RL_RS17960	COG1132	(ABC) transporter
RL_RS17970	COG1132	(ABC) transporter
RL_RS17975	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RL_RS17990	COG0408	coproporphyrinogen oxidase activity
RL_RS18005	COG0617	tRNA 3'-terminal CCA addition
RL_RS18020	COG0714	Associated with various cellular activities
RL_RS18040	COG0454	-acetyltransferase
RL_RS18050	COG0435	Glutathione S-transferase
RL_RS18085	COG1733	regulation of RNA biosynthetic process
RL_RS18090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RL_RS18095	COG3135	benzoate transporter
RL_RS18100	COG0740	serine-type endopeptidase activity
RL_RS18105	COG3416	Protein conserved in bacteria
RL_RS18110	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RL_RS18115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RL_RS18130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RL_RS18130	COG0512	Glutamine amidotransferase of anthranilate synthase
RL_RS18135	COG1629	transport
RL_RS18135	COG4771	TonB-dependent receptor
RL_RS18150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RL_RS18155	COG2862	Uncharacterized protein family, UPF0114
RL_RS18165	COG2197	response regulator
RL_RS18185	COG1435	thymidine kinase activity
RL_RS18200	COG4175	Glycine betaine
RL_RS18215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RL_RS18230	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RL_RS18240	COG0366	Alpha amylase catalytic
RL_RS18250	COG0601	transmembrane transport
RL_RS18255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS18265	COG4608	Belongs to the ABC transporter superfamily
RL_RS18270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS18280	COG0174	glutamine synthetase
RL_RS18295	COG1846	Transcriptional regulator
RL_RS18300	COG1160	GTP binding
RL_RS18320	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RL_RS18335	COG0024	Methionine aminopeptidase
RL_RS18350	COG4941	Belongs to the sigma-70 factor family
RL_RS18355	COG3795	YCII-related domain
RL_RS18365	COG4977	sequence-specific DNA binding
RL_RS18375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RL_RS18380	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS18390	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RL_RS18405	COG0583	DNA-binding transcription factor activity
RL_RS18430	COG0402	S-adenosylhomocysteine deaminase activity
RL_RS18450	COG2268	Band 7 protein
RL_RS18460	COG2351	hydroxyisourate hydrolase activity
RL_RS18465	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
RL_RS18475	COG3648	Uricase
RL_RS18475	COG3195	allantoin biosynthetic process
RL_RS18490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS18495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS18495	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RL_RS18500	COG5002	protein histidine kinase activity
RL_RS18500	COG2205	protein histidine kinase activity
RL_RS18500	COG0784	Response regulator, receiver
RL_RS18510	COG0477	Major facilitator Superfamily
RL_RS18515	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS18525	COG4335	DNA alkylation repair
RL_RS18530	COG0513	Belongs to the DEAD box helicase family
RL_RS18535	COG5002	protein histidine kinase activity
RL_RS18570	COG1136	(ABC) transporter
RL_RS18590	COG2308	Evidence 4 Homologs of previously reported genes of
RL_RS18610	COG0129	dihydroxy-acid dehydratase activity
RL_RS18615	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS18625	COG4214	carbohydrate transport
RL_RS18635	COG4213	ABC transporter substrate-binding protein
RL_RS18660	COG0673	inositol 2-dehydrogenase activity
RL_RS18670	COG4213	ABC transporter substrate-binding protein
RL_RS18675	COG4214	carbohydrate transport
RL_RS18680	COG1129	ABC transporter
RL_RS18695	COG3108	Peptidase M15
RL_RS18700	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RL_RS18715	COG1216	Glycosyl transferase, family 2
RL_RS18715	COG0463	Glycosyl transferase, family 2
RL_RS18720	COG1132	(ABC) transporter
RL_RS18725	COG1442	glycosyl transferase family 8
RL_RS18725	COG1216	Glycosyl transferase, family 2
RL_RS18760	COG1396	sequence-specific DNA binding
RL_RS18780	COG0438	transferase activity, transferring glycosyl groups
RL_RS18810	COG0463	Glycosyl transferase, family 2
RL_RS18830	COG1215	transferase activity, transferring glycosyl groups
RL_RS18860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS18865	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
RL_RS18885	COG3206	protein involved in exopolysaccharide biosynthesis
RL_RS18885	COG0489	protein tyrosine kinase activity
RL_RS18910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RL_RS18915	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RL_RS18930	COG0400	carboxylic ester hydrolase activity
RL_RS18935	COG0346	lactoylglutathione lyase activity
RL_RS18940	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RL_RS18945	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RL_RS18950	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RL_RS18950	COG0662	Cupin 2, conserved barrel domain protein
RL_RS18965	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RL_RS18975	COG1309	transcriptional regulator
RL_RS18980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS18985	COG1131	(ABC) transporter
RL_RS18990	COG0842	Transport permease protein
RL_RS18995	COG0842	Transport permease protein
RL_RS19005	COG0673	inositol 2-dehydrogenase activity
RL_RS19015	COG2076	Multidrug Resistance protein
RL_RS19025	COG2346	COG2346, Truncated hemoglobins
RL_RS19050	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RL_RS19070	COG4558	Periplasmic binding protein
RL_RS19075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RL_RS19080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RL_RS19105	COG0784	Response regulator, receiver
RL_RS19115	COG0493	'glutamate synthase
RL_RS19140	COG0583	DNA-binding transcription factor activity
RL_RS19150	COG4251	negative regulation of phosphorylation
RL_RS19155	COG1309	transcriptional regulator
RL_RS19185	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RL_RS19190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RL_RS19195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RL_RS19215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RL_RS19220	COG0830	nickel cation binding
RL_RS19230	COG3706	GGDEF domain
RL_RS19240	COG0804	urea catabolic process
RL_RS19245	COG1442	glycosyl transferase family 8
RL_RS19250	COG3755	Protein conserved in bacteria
RL_RS19255	COG0832	Belongs to the urease beta subunit family
RL_RS19260	COG3813	Protein conserved in bacteria
RL_RS19265	COG0831	urea catabolic process
RL_RS19270	COG0829	nickel cation binding
RL_RS19305	COG2198	Histidine kinase
RL_RS19305	COG2205	protein histidine kinase activity
RL_RS19305	COG0784	Response regulator, receiver
RL_RS19315	COG0683	leucine binding
RL_RS19340	COG0559	Belongs to the binding-protein-dependent transport system permease family
RL_RS19415	COG0564	pseudouridine synthase activity
RL_RS19420	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RL_RS19430	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RL_RS19450	COG0129	dihydroxy-acid dehydratase activity
RL_RS19455	COG2084	Dehydrogenase
RL_RS19470	COG0657	acetylesterase activity
RL_RS19480	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19485	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19500	COG2094	Belongs to the DNA glycosylase MPG family
RL_RS19525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS19535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RL_RS19545	COG1959	2 iron, 2 sulfur cluster binding
RL_RS19550	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19555	COG3622	Belongs to the hyi family
RL_RS19560	COG1609	Transcriptional regulator
RL_RS19565	COG0747	negative chemotaxis
RL_RS19575	COG0601	transmembrane transport
RL_RS19580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS19590	COG3622	Belongs to the hyi family
RL_RS19595	COG2084	Dehydrogenase
RL_RS19615	COG3842	ATPase activity
RL_RS19620	COG0395	ABC-type sugar transport system, permease component
RL_RS19625	COG1175	transmembrane transport
RL_RS19630	COG1653	transport
RL_RS19635	COG1846	Transcriptional regulator
RL_RS19635	COG1940	carbohydrate kinase activity
RL_RS19640	COG1653	transport
RL_RS19675	COG2244	polysaccharide biosynthetic process
RL_RS19680	COG0438	transferase activity, transferring glycosyl groups
RL_RS19700	COG0489	protein tyrosine kinase activity
RL_RS19755	COG4993	Dehydrogenase
RL_RS19760	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19765	COG1376	ErfK ybiS ycfS ynhG family protein
RL_RS19790	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19795	COG2186	Transcriptional regulator
RL_RS19810	COG1129	ABC transporter
RL_RS19815	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS19820	COG3842	ATPase activity
RL_RS19825	COG0395	ABC-type sugar transport system, permease component
RL_RS19830	COG1175	transmembrane transport
RL_RS19840	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS19845	COG2186	Transcriptional regulator
RL_RS19850	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS19865	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RL_RS19890	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS19895	COG3842	ATPase activity
RL_RS19910	COG1653	transport
RL_RS19925	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS19930	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS19985	COG0471	metal ion transport
RL_RS19985	COG3273	potassium ion transport
RL_RS19990	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RL_RS19995	COG1309	transcriptional regulator
RL_RS20000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RL_RS20005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RL_RS20025	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS20030	COG1177	transmembrane transport
RL_RS20035	COG3842	ATPase activity
RL_RS20045	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RL_RS20055	COG1121	(ABC) transporter
RL_RS20060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RL_RS20065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RL_RS20070	COG1473	amidohydrolase
RL_RS20100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RL_RS20125	COG5001	Diguanylate cyclase
RL_RS20125	COG3300	MHYT domain
RL_RS20135	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RL_RS20140	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS20160	COG0683	leucine binding
RL_RS20170	COG0559	Belongs to the binding-protein-dependent transport system permease family
RL_RS20205	COG1696	Membrane protein involved in D-alanine export
RL_RS20415	COG0482	sulfurtransferase activity
RL_RS20420	COG5001	Diguanylate cyclase
RL_RS20430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RL_RS20450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RL_RS20455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RL_RS20460	COG0037	tRNA processing
RL_RS20470	COG2885	chlorophyll binding
RL_RS20475	COG0823	Involved in the tonB-independent uptake of proteins
RL_RS20490	COG0848	biopolymer transport protein
RL_RS20500	COG0824	Thioesterase
RL_RS20530	COG1692	metallophosphoesterase
RL_RS20545	COG0217	transcriptional regulatory protein
RL_RS20550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RL_RS20555	COG0840	transmembrane signaling receptor activity
RL_RS20560	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RL_RS20575	COG0632	four-way junction helicase activity
RL_RS20580	COG2255	four-way junction helicase activity
RL_RS20585	COG1408	metallophosphoesterase
RL_RS20590	COG0494	nUDIX hydrolase
RL_RS20595	COG2318	DinB family
RL_RS20605	COG0392	lysyltransferase activity
RL_RS20605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
RL_RS20615	COG0668	transmembrane transport
RL_RS20625	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RL_RS20700	COG0126	phosphoglycerate kinase activity
RL_RS20705	COG3588	fructose-bisphosphate aldolase
RL_RS20710	COG0384	phenazine biosynthesis protein PhzF
RL_RS20730	COG0254	rRNA binding
RL_RS20735	COG1132	(ABC) transporter
RL_RS20745	COG3422	double-strand break repair
RL_RS20770	COG0483	inositol monophosphate 1-phosphatase activity
RL_RS20775	COG1309	transcriptional regulator
RL_RS20780	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS20785	COG2201	protein-glutamate methylesterase activity
RL_RS20795	COG0835	chemotaxis
RL_RS20800	COG0840	transmembrane signaling receptor activity
RL_RS20805	COG0840	transmembrane signaling receptor activity
RL_RS20815	COG0835	chemotaxis
RL_RS20820	COG0643	Histidine kinase
RL_RS20820	COG2198	Histidine kinase
RL_RS20855	COG0640	Transcriptional regulator
RL_RS20870	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RL_RS20875	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RL_RS20880	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RL_RS20885	COG0457	Tetratricopeptide repeat
RL_RS20895	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS20915	COG4221	oxidoreductase activity
RL_RS20930	COG0583	DNA-binding transcription factor activity
RL_RS20935	COG1942	4-Oxalocrotonate Tautomerase
RL_RS20950	COG1280	lysine exporter protein (LysE YggA)
RL_RS20955	COG0469	pyruvate kinase activity
RL_RS20975	COG3750	Belongs to the UPF0335 family
RL_RS20980	COG3108	Peptidase M15
RL_RS20985	COG2204	response regulator
RL_RS21015	COG5310	Homospermidine synthase
RL_RS21030	COG0737	Belongs to the 5'-nucleotidase family
RL_RS21035	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RL_RS21040	COG0330	HflC and HflK could
RL_RS21060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RL_RS21065	COG2951	lytic endotransglycosylase activity
RL_RS21080	COG0067	glutamate synthase
RL_RS21080	COG0069	glutamate synthase activity
RL_RS21080	COG0070	glutamate synthase
RL_RS21100	COG0071	Belongs to the small heat shock protein (HSP20) family
RL_RS21205	COG2308	Evidence 4 Homologs of previously reported genes of
RL_RS21205	COG2307	Protein conserved in bacteria
RL_RS21220	COG0058	SHG alpha-glucan phosphorylase activity
RL_RS21225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RL_RS21230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RL_RS21235	COG0297	glycogen (starch) synthase activity
RL_RS21240	COG0033	Phosphoglucomutase
RL_RS21245	COG1523	belongs to the glycosyl hydrolase 13 family
RL_RS21265	COG0446	pyridine nucleotide-disulphide oxidoreductase
RL_RS21265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RL_RS21280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS21300	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RL_RS21310	COG3920	Histidine kinase
RL_RS21310	COG2202	Pas domain
RL_RS21345	COG5001	Diguanylate cyclase
RL_RS21350	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RL_RS21360	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RL_RS21365	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RL_RS21370	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RL_RS21375	COG1609	Transcriptional regulator
RL_RS21380	COG1846	Transcriptional regulator
RL_RS21390	COG0523	cobalamin synthesis protein
RL_RS21415	COG3706	GGDEF domain
RL_RS21435	COG0583	DNA-binding transcription factor activity
RL_RS21465	COG0800	Aldolase
RL_RS21470	COG2954	triphosphatase activity
RL_RS21485	COG1054	Belongs to the UPF0176 family
RL_RS21505	COG0673	inositol 2-dehydrogenase activity
RL_RS21515	COG1879	ABC-type sugar transport system periplasmic component
RL_RS21520	COG1172	Belongs to the binding-protein-dependent transport system permease family
RL_RS21525	COG1129	ABC transporter
RL_RS21530	COG1609	Transcriptional regulator
RL_RS21535	COG2115	Belongs to the xylose isomerase family
RL_RS21540	COG1070	Carbohydrate kinase
RL_RS21545	COG1609	Transcriptional regulator
RL_RS21570	COG1253	flavin adenine dinucleotide binding
RL_RS21575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RL_RS21580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RL_RS21590	COG2207	Transcriptional regulator
RL_RS21600	COG0583	DNA-binding transcription factor activity
RL_RS21605	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RL_RS21610	COG3842	ATPase activity
RL_RS21615	COG1176	ABC-type spermidine putrescine transport system, permease component I
RL_RS21620	COG1177	transmembrane transport
RL_RS21670	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RL_RS21695	COG1309	transcriptional regulator
RL_RS21735	COG0395	ABC-type sugar transport system, permease component
RL_RS21760	COG1940	carbohydrate kinase activity
RL_RS21785	COG1764	response to oxidative stress
RL_RS21790	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS21805	COG1129	ABC transporter
RL_RS21815	COG2186	Transcriptional regulator
RL_RS21820	COG4948	Mandelate Racemase Muconate Lactonizing
RL_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS21835	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RL_RS21850	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS21855	COG3386	PFAM SMP-30 Gluconolaconase
RL_RS21865	COG3842	ATPase activity
RL_RS21870	COG0395	ABC-type sugar transport system, permease component
RL_RS21875	COG1175	transmembrane transport
RL_RS21880	COG1653	transport
RL_RS21890	COG1609	Transcriptional regulator
RL_RS21900	COG3842	ATPase activity
RL_RS21905	COG0395	ABC-type sugar transport system, permease component
RL_RS21910	COG1175	transmembrane transport
RL_RS21915	COG1653	transport
RL_RS21920	COG1609	Transcriptional regulator
RL_RS21925	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RL_RS21930	COG0720	synthase
RL_RS21935	COG0602	queuosine metabolic process
RL_RS21945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RL_RS21950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RL_RS21955	COG1780	Probably involved in ribonucleotide reductase function
RL_RS21975	COG0493	'glutamate synthase
RL_RS21975	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RL_RS21990	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS22000	COG0693	protein deglycase activity
RL_RS22010	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS22015	COG0387	Pfam Sodium calcium exchanger
RL_RS22035	COG0840	transmembrane signaling receptor activity
RL_RS22035	COG2972	Histidine kinase
RL_RS22075	COG0542	response to heat
RL_RS22085	COG2890	protein-(glutamine-N5) methyltransferase activity
RL_RS22090	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RL_RS22100	COG0527	aspartate kinase activity
RL_RS22105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RL_RS22115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RL_RS22130	COG2226	methyltransferase
RL_RS22145	COG0494	nUDIX hydrolase
RL_RS22150	COG0456	acetyltransferase
RL_RS22155	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RL_RS22160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RL_RS22165	COG0653	protein targeting
RL_RS22180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RL_RS22185	COG0667	Aldo Keto reductase
RL_RS22215	COG4651	solute:proton antiporter activity
RL_RS22215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RL_RS22245	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RL_RS22255	COG0300	oxidoreductase activity
RL_RS22275	COG2086	electron transfer activity
RL_RS22280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RL_RS22285	COG1250	3-hydroxyacyl-CoA dehydrogenase
RL_RS22290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RL_RS22295	COG0165	Argininosuccinate lyase
RL_RS22330	COG2884	Cell division ATP-binding protein ftsE
RL_RS22350	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RL_RS22365	COG0287	Prephenate dehydrogenase
RL_RS22370	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RL_RS22375	COG2226	methyltransferase
RL_RS22380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RL_RS22400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RL_RS22440	COG4536	flavin adenine dinucleotide binding
RL_RS22445	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RL_RS22450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RL_RS22460	COG4974	Belongs to the 'phage' integrase family
RL_RS22465	COG0825	malonyl-CoA metabolic process
RL_RS22470	COG3034	peptidoglycan biosynthetic process
RL_RS22480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RL_RS22495	COG2186	Transcriptional regulator
RL_RS22500	COG0523	cobalamin synthesis protein
RL_RS22505	COG1686	Belongs to the peptidase S11 family
RL_RS22520	COG4303	Ethanolamine ammonia lyase large subunit
RL_RS22525	COG4302	ethanolamine ammonia-lyase activity
RL_RS22530	COG0531	amino acid
RL_RS22555	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RL_RS22570	COG0395	ABC-type sugar transport system, permease component
RL_RS22575	COG1175	transmembrane transport
RL_RS22590	COG0156	8-amino-7-oxononanoate synthase activity
RL_RS22600	COG0729	surface antigen
RL_RS22615	COG0010	Belongs to the arginase family
RL_RS22620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RL_RS22625	COG0835	chemotaxis
RL_RS22635	COG2223	nitrite transmembrane transporter activity
RL_RS22645	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RL_RS22650	COG3383	formate dehydrogenase (NAD+) activity
RL_RS22665	COG0583	DNA-binding transcription factor activity
RL_RS22670	COG0640	Transcriptional regulator
RL_RS22675	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS22695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RL_RS22700	COG1116	anion transmembrane transporter activity
RL_RS22705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RL_RS22720	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RL_RS22730	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RL_RS22735	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RL_RS22740	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RL_RS22745	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RL_RS22760	COG4608	Belongs to the ABC transporter superfamily
RL_RS22765	COG0444	Belongs to the ABC transporter superfamily
RL_RS22770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS22775	COG0601	transmembrane transport
RL_RS22785	COG3664	PFAM glycoside hydrolase family 39
RL_RS22795	COG0673	inositol 2-dehydrogenase activity
RL_RS22800	COG0129	dihydroxy-acid dehydratase activity
RL_RS22810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS22825	COG4974	Belongs to the 'phage' integrase family
RL_RS22835	COG3038	cytochrome b561
RL_RS22845	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS22860	COG0508	dehydrogenase complex catalyzes the overall conversion of
RL_RS22870	COG0567	Dehydrogenase, E1 component
RL_RS22875	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RL_RS22885	COG0045	succinate-CoA ligase (ADP-forming) activity
RL_RS22890	COG0039	L-malate dehydrogenase activity
RL_RS22895	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RL_RS22900	COG2845	Protein of unknown function (DUF459)
RL_RS22935	COG0251	oxidation-reduction process
RL_RS22945	COG3842	ATPase activity
RL_RS22950	COG4149	molybdate abc transporter
RL_RS22970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS22975	COG0765	amino acid transport
RL_RS22980	COG0765	amino acid transport
RL_RS22985	COG2423	ornithine cyclodeaminase activity
RL_RS23015	COG0601	transmembrane transport
RL_RS23040	COG2986	histidine ammonia-lyase
RL_RS23050	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RL_RS23060	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RL_RS23070	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RL_RS23070	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RL_RS23075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RL_RS23095	COG2186	Transcriptional regulator
RL_RS23105	COG0765	amino acid transport
RL_RS23110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RL_RS23120	COG1126	abc transporter atp-binding protein
RL_RS23155	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RL_RS23160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RL_RS23165	COG0181	hydroxymethylbilane synthase activity
RL_RS23190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RL_RS23205	COG1872	DUF167
RL_RS23210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RL_RS23220	COG1217	gtp-binding protein TYPA
RL_RS23225	COG0339	signal peptide processing
RL_RS23260	COG0137	argininosuccinate synthase activity
RL_RS23285	COG4120	Belongs to the binding-protein-dependent transport system permease family
RL_RS23295	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RL_RS23305	COG1595	DNA-templated transcription, initiation
RL_RS23315	COG2154	pterin-4-alpha-carbinolamine dehydratase
RL_RS23325	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RL_RS23335	COG4181	ATPase activity
RL_RS23345	COG0670	Belongs to the BI1 family
RL_RS23365	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RL_RS23370	COG4133	protoheme IX ABC transporter activity
RL_RS23375	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RL_RS23380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RL_RS23400	COG2917	probably involved in intracellular septation
RL_RS23405	COG0552	protein localization to endoplasmic reticulum
RL_RS23410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RL_RS23415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RL_RS23425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RL_RS23430	COG0287	Prephenate dehydrogenase
RL_RS23430	COG1605	Chorismate mutase
RL_RS23435	COG0228	four-way junction DNA binding
RL_RS23440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RL_RS23445	COG0336	Belongs to the RNA methyltransferase TrmD family
RL_RS23450	COG0335	large ribosomal subunit rRNA binding
RL_RS23460	COG0765	amino acid transport
RL_RS23465	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RL_RS23475	COG0656	L-ascorbic acid biosynthetic process
RL_RS23485	COG0745	RESPONSE REGULATOR receiver
RL_RS23500	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RL_RS23505	COG1674	ftsk spoiiie
RL_RS23510	COG0004	ammonium transporteR
RL_RS23515	COG0347	Belongs to the P(II) protein family
RL_RS23520	COG1946	Acyl-CoA thioesterase
RL_RS23525	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RL_RS23530	COG2835	tetraacyldisaccharide 4'-kinase activity
RL_RS23570	COG4166	transmembrane transport
RL_RS23575	COG0601	transmembrane transport
RL_RS23580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS23585	COG0405	Gamma-glutamyltransferase
RL_RS23605	COG3842	ATPase activity
RL_RS23625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RL_RS23630	COG5383	Protein conserved in bacteria
RL_RS23645	COG0438	transferase activity, transferring glycosyl groups
RL_RS23670	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RL_RS23680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RL_RS23685	COG1509	lysine 2,3-aminomutase activity
RL_RS23695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RL_RS23700	COG4821	SIS domain
RL_RS23705	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RL_RS23710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RL_RS23715	COG2188	Transcriptional regulator
RL_RS23725	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RL_RS23730	COG4178	(ABC) transporter
RL_RS23740	COG0488	(ABC) transporter
RL_RS23765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RL_RS23770	COG1329	Transcriptional regulator
RL_RS23775	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RL_RS23795	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS23800	COG0183	Belongs to the thiolase family
RL_RS23805	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RL_RS23815	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RL_RS23830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RL_RS23835	COG0142	geranyltranstransferase activity
RL_RS23840	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RL_RS23845	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RL_RS23850	COG2223	nitrite transmembrane transporter activity
RL_RS23855	COG1349	DNA-binding transcription factor activity
RL_RS23860	COG0697	spore germination
RL_RS23865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RL_RS23870	COG0765	amino acid transport
RL_RS23875	COG1126	abc transporter atp-binding protein
RL_RS23880	COG0431	NADPH-dependent FMN reductase
RL_RS23885	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RL_RS23895	COG1132	(ABC) transporter
RL_RS23915	COG3459	Glycosyltransferase 36 associated
RL_RS23925	COG4608	Belongs to the ABC transporter superfamily
RL_RS23930	COG0444	Belongs to the ABC transporter superfamily
RL_RS23935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RL_RS23940	COG0601	transmembrane transport
RL_RS23955	COG4211	Belongs to the binding-protein-dependent transport system permease family
RL_RS23960	COG1129	ABC transporter
RL_RS24025	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RL_RS24040	COG4974	Belongs to the 'phage' integrase family
RL_RS24065	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RL_RS24070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RL_RS24090	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RL_RS24095	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RL_RS24100	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RL_RS24105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RL_RS24110	COG0725	ABC transporter, periplasmic molybdate-binding protein
RL_RS24115	COG4149	molybdate abc transporter
RL_RS24120	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RL_RS24130	COG0799	negative regulation of ribosome biogenesis
RL_RS24135	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RL_RS24145	COG0793	Belongs to the peptidase S41A family
RL_RS24155	COG0494	nUDIX hydrolase
RL_RS24170	COG0587	DNA-directed DNA polymerase activity
RL_RS24210	COG0066	3-isopropylmalate dehydratase activity
RL_RS24220	COG0473	3-isopropylmalate dehydrogenase activity
RL_RS24225	COG0671	phosphoesterase, PA-phosphatase related
RL_RS24240	COG1136	(ABC) transporter
RL_RS24250	COG1785	Belongs to the alkaline phosphatase family
RL_RS24260	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RL_RS24275	COG0288	reversible hydration of carbon dioxide
RL_RS24285	COG2902	Dehydrogenase
RL_RS24290	COG2270	Major facilitator Superfamily
RL_RS24295	COG0138	bifunctional purine biosynthesis protein purh
RL_RS24310	COG0501	Belongs to the peptidase M48B family
RL_RS24320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RL_RS24340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RL_RS24345	COG0495	leucyl-tRNA aminoacylation
RL_RS24370	COG0357	Ribosomal RNA small subunit methyltransferase G
RL_RS24375	COG0445	tRNA wobble uridine modification
RL_RS24380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RL_RS24385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RL_RS24390	COG1981	membrane
RL_RS24395	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RL_RS24575	COG0642	Histidine kinase
RL_RS24655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RL_RS24660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RL_RS24805	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS25085	COG0539	negative regulation of cytoplasmic translation
RL_RS25150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RL_RS25240	COG0133	tryptophan synthase activity
RL_RS25260	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RL_RS25425	COG2205	protein histidine kinase activity
RL_RS25550	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS25765	COG0246	Mannitol dehydrogenase
RL_RS25815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RL_RS25980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RL_RS25995	COG1074	ATP-dependent DNA helicase activity
RL_RS26000	COG1074	ATP-dependent DNA helicase activity
RL_RS26170	COG1643	Atp-dependent helicase
RL_RS26290	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS26710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS26710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS26725	COG1674	ftsk spoiiie
RL_RS26735	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RL_RS26775	COG4778	phosphonate C-P lyase system protein PhnL
RL_RS26815	COG1132	(ABC) transporter
RL_RS26955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RL_RS27410	COG2814	Major facilitator Superfamily
RL_RS27660	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RL_RS28040	COG1012	belongs to the aldehyde dehydrogenase family
RL_RS28080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RL_RS28130	COG2813	Specifically methylates the guanine in position
RL_RS28140	COG0596	Alpha beta hydrolase
RL_RS28185	COG2951	lytic endotransglycosylase activity
RL_RS28320	COG5001	Diguanylate cyclase
RL_RS28320	COG3300	MHYT domain
RL_RS28530	COG3845	ABC transporter
RL_RS28565	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RL_RS28585	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
RL_RS28590	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RL_RS28615	COG4964	Belongs to the GSP D family
RL_RS29650	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RL_RS29980	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RL_RS30005	COG1643	Atp-dependent helicase
RL_RS30080	COG3459	Glycosyltransferase 36 associated
RL_RS30310	COG0246	Mannitol dehydrogenase
RL_RS30365	COG0539	negative regulation of cytoplasmic translation
RL_RS30470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RL_RS30475	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RL_RS30660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS30660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS30665	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS30665	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RL_RS30740	COG4778	phosphonate C-P lyase system protein PhnL
RL_RS30800	COG1132	(ABC) transporter
RL_RS30895	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RL_RS31025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RL_RS31290	COG0667	Aldo Keto reductase
RL_RS31710	COG1957	nucleoside hydrolase
RL_RS31845	COG0784	Response regulator, receiver
RL_RS31845	COG2205	protein histidine kinase activity
RL_RS31850	COG3850	Histidine kinase
RL_RS31850	COG4999	Histidine kinase
RL_RS31850	COG2205	protein histidine kinase activity
RL_RS31850	COG3437	response regulator, receiver
RL_RS31930	COG0840	transmembrane signaling receptor activity
RL_RS33000	COG0435	Glutathione S-transferase
RL_RS33365	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS33370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RL_RS33605	COG0539	negative regulation of cytoplasmic translation
RL_RS33610	COG0539	negative regulation of cytoplasmic translation
RL_RS33740	COG2951	lytic endotransglycosylase activity
RL_RS33875	COG1674	ftsk spoiiie
RL_RS33985	COG4166	transmembrane transport
RL_RS34365	COG0072	phenylalanine-tRNA ligase activity
RL_RS34365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RL_RS34685	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RL_RS34765	COG2814	Major facilitator Superfamily
RL_RS35190	COG0706	membrane insertase activity
RL_RS35400	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RL_RS35410	COG0166	Belongs to the GPI family
RL_RS35490	COG2721	sulfolactate sulfo-lyase activity
RL_RS36110	COG1028	Short-chain dehydrogenase reductase Sdr
RL_RS36420	COG1706	bacterial-type flagellum-dependent cell motility
RL_RS36540	COG1653	transport
RL_RS36560	COG1175	transmembrane transport
RL_RS36905	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RL_RS36905	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RL_RS36970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family