locus-tag	class	description
D4A92_RS00015	COG1408	metallophosphoesterase
D4A92_RS00025	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D4A92_RS00025	COG0446	pyridine nucleotide-disulphide oxidoreductase
D4A92_RS00030	COG4311	Sarcosine oxidase, delta subunit
D4A92_RS00035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS00050	COG2197	response regulator
D4A92_RS00100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4A92_RS00110	COG0564	pseudouridine synthase activity
D4A92_RS00115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4A92_RS00125	COG1131	(ABC) transporter
D4A92_RS00135	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D4A92_RS00140	COG0697	spore germination
D4A92_RS00145	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D4A92_RS00165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS00170	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D4A92_RS00190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D4A92_RS00200	COG0346	lactoylglutathione lyase activity
D4A92_RS00210	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D4A92_RS00225	COG4948	Mandelate Racemase Muconate Lactonizing
D4A92_RS00230	COG0482	sulfurtransferase activity
D4A92_RS00310	COG3299	homolog of phage Mu protein gp47
D4A92_RS00380	COG4397	Mu-like prophage major head subunit gpT
D4A92_RS00405	COG4383	Mu-like prophage protein gp29
D4A92_RS00410	COG4373	Mu-like prophage FluMu protein gp28
D4A92_RS00515	COG2842	Transposition protein
D4A92_RS00520	COG2801	Transposase and inactivated derivatives
D4A92_RS00575	COG0673	inositol 2-dehydrogenase activity
D4A92_RS00595	COG1294	oxidase, subunit
D4A92_RS00600	COG1271	oxidase subunit
D4A92_RS00605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D4A92_RS00620	COG0840	transmembrane signaling receptor activity
D4A92_RS00625	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D4A92_RS00630	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D4A92_RS00645	COG0632	four-way junction helicase activity
D4A92_RS00660	COG2255	four-way junction helicase activity
D4A92_RS00670	COG0824	Thioesterase
D4A92_RS00680	COG0848	biopolymer transport protein
D4A92_RS00690	COG0823	Involved in the tonB-independent uptake of proteins
D4A92_RS00695	COG2885	chlorophyll binding
D4A92_RS00705	COG0037	tRNA processing
D4A92_RS00710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A92_RS00715	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D4A92_RS00720	COG0217	transcriptional regulatory protein
D4A92_RS00735	COG1692	metallophosphoesterase
D4A92_RS00740	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D4A92_RS00745	COG0840	transmembrane signaling receptor activity
D4A92_RS00745	COG2972	Histidine kinase
D4A92_RS00775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D4A92_RS00780	COG3263	regulation of cellular component size
D4A92_RS00785	COG0126	phosphoglycerate kinase activity
D4A92_RS00790	COG3588	fructose-bisphosphate aldolase
D4A92_RS00795	COG0384	phenazine biosynthesis protein PhzF
D4A92_RS00830	COG0254	rRNA binding
D4A92_RS00835	COG1132	(ABC) transporter
D4A92_RS00855	COG0483	inositol monophosphate 1-phosphatase activity
D4A92_RS00880	COG0640	Transcriptional regulator
D4A92_RS00895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D4A92_RS00900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D4A92_RS00905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D4A92_RS00910	COG0457	Tetratricopeptide repeat
D4A92_RS00915	COG0596	Alpha beta hydrolase
D4A92_RS00920	COG0469	pyruvate kinase activity
D4A92_RS00940	COG3750	Belongs to the UPF0335 family
D4A92_RS00950	COG2204	response regulator
D4A92_RS00960	COG0512	Glutamine amidotransferase of anthranilate synthase
D4A92_RS00960	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4A92_RS00975	COG4221	oxidoreductase activity
D4A92_RS00980	COG0583	DNA-binding transcription factor activity
D4A92_RS00990	COG5310	Homospermidine synthase
D4A92_RS01000	COG0737	Belongs to the 5'-nucleotidase family
D4A92_RS01005	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D4A92_RS01015	COG0840	transmembrane signaling receptor activity
D4A92_RS01015	COG2972	Histidine kinase
D4A92_RS01020	COG0330	HflC and HflK could
D4A92_RS01030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D4A92_RS01030	COG0517	IMP dehydrogenase activity
D4A92_RS01040	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D4A92_RS01045	COG2951	lytic endotransglycosylase activity
D4A92_RS01070	COG0067	glutamate synthase
D4A92_RS01070	COG0069	glutamate synthase activity
D4A92_RS01070	COG0070	glutamate synthase
D4A92_RS01085	COG3220	belongs to the UPF0276 family
D4A92_RS01100	COG0071	Belongs to the small heat shock protein (HSP20) family
D4A92_RS01145	COG0662	Cupin 2, conserved barrel domain protein
D4A92_RS01145	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D4A92_RS01155	COG2307	Protein conserved in bacteria
D4A92_RS01155	COG2308	Evidence 4 Homologs of previously reported genes of
D4A92_RS01175	COG0058	SHG alpha-glucan phosphorylase activity
D4A92_RS01180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D4A92_RS01185	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D4A92_RS01190	COG0297	glycogen (starch) synthase activity
D4A92_RS01195	COG0033	Phosphoglucomutase
D4A92_RS01210	COG0798	PFAM Bile acid sodium symporter
D4A92_RS01220	COG0431	NADPH-dependent FMN reductase
D4A92_RS01240	COG2337	Toxic component of a toxin-antitoxin (TA) module
D4A92_RS01255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D4A92_RS01255	COG0446	pyridine nucleotide-disulphide oxidoreductase
D4A92_RS01265	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS01270	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D4A92_RS01290	COG5001	Diguanylate cyclase
D4A92_RS01300	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D4A92_RS01305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D4A92_RS01315	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4A92_RS01320	COG1609	Transcriptional regulator
D4A92_RS01325	COG1846	Transcriptional regulator
D4A92_RS01335	COG0523	cobalamin synthesis protein
D4A92_RS01345	COG0840	transmembrane signaling receptor activity
D4A92_RS01360	COG3047	cAMP biosynthetic process
D4A92_RS01385	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D4A92_RS01405	COG0800	Aldolase
D4A92_RS01410	COG2954	triphosphatase activity
D4A92_RS01420	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS01425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS01430	COG0601	transmembrane transport
D4A92_RS01440	COG1054	Belongs to the UPF0176 family
D4A92_RS01450	COG5001	Diguanylate cyclase
D4A92_RS01460	COG1733	regulation of RNA biosynthetic process
D4A92_RS01470	COG0673	inositol 2-dehydrogenase activity
D4A92_RS01485	COG1879	ABC-type sugar transport system periplasmic component
D4A92_RS01490	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS01495	COG1129	ABC transporter
D4A92_RS01500	COG1609	Transcriptional regulator
D4A92_RS01505	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D4A92_RS01510	COG2115	Belongs to the xylose isomerase family
D4A92_RS01515	COG1070	Carbohydrate kinase
D4A92_RS01520	COG1609	Transcriptional regulator
D4A92_RS01535	COG1309	transcriptional regulator
D4A92_RS01540	COG1253	flavin adenine dinucleotide binding
D4A92_RS01545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D4A92_RS01550	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D4A92_RS01565	COG1121	(ABC) transporter
D4A92_RS01570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D4A92_RS01575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D4A92_RS01590	COG0583	DNA-binding transcription factor activity
D4A92_RS01595	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D4A92_RS01600	COG3842	ATPase activity
D4A92_RS01605	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS01610	COG1177	transmembrane transport
D4A92_RS01630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D4A92_RS01640	COG3668	Plasmid stabilization system
D4A92_RS01650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D4A92_RS01670	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4A92_RS01680	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS01685	COG1473	amidohydrolase
D4A92_RS01695	COG0601	transmembrane transport
D4A92_RS01700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS01705	COG0671	phosphoesterase, PA-phosphatase related
D4A92_RS01720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D4A92_RS01730	COG0154	amidase activity
D4A92_RS01735	COG3842	ATPase activity
D4A92_RS01740	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS01745	COG1177	transmembrane transport
D4A92_RS01760	COG1228	amidohydrolase
D4A92_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS01795	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D4A92_RS01810	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
D4A92_RS01825	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D4A92_RS01870	COG0784	Response regulator, receiver
D4A92_RS01890	COG3237	CsbD-like
D4A92_RS01910	COG0625	glutathione transferase activity
D4A92_RS01915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D4A92_RS01920	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D4A92_RS01935	COG1396	sequence-specific DNA binding
D4A92_RS01935	COG3800	Transcriptional regulator
D4A92_RS01940	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D4A92_RS01945	COG0625	glutathione transferase activity
D4A92_RS01970	COG4770	biotin carboxylase activity
D4A92_RS01985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D4A92_RS01985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D4A92_RS02000	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS02005	COG3842	ATPase activity
D4A92_RS02020	COG0583	DNA-binding transcription factor activity
D4A92_RS02040	COG3718	enzyme involved in inositol metabolism
D4A92_RS02055	COG3962	Belongs to the TPP enzyme family
D4A92_RS02060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A92_RS02070	COG0673	inositol 2-dehydrogenase activity
D4A92_RS02085	COG1609	Transcriptional regulator
D4A92_RS02105	COG5425	PFAM Usg family protein
D4A92_RS02110	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D4A92_RS02115	COG0459	protein refolding
D4A92_RS02120	COG2200	EAL domain
D4A92_RS02130	COG0745	RESPONSE REGULATOR receiver
D4A92_RS02165	COG2972	Histidine kinase
D4A92_RS02165	COG0840	transmembrane signaling receptor activity
D4A92_RS02170	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D4A92_RS02180	COG1486	melibiose metabolic process
D4A92_RS02185	COG1175	transmembrane transport
D4A92_RS02190	COG0395	ABC-type sugar transport system, permease component
D4A92_RS02195	COG3842	ATPase activity
D4A92_RS02210	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D4A92_RS02215	COG3002	Belongs to the UPF0753 family
D4A92_RS02220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A92_RS02240	COG1595	DNA-templated transcription, initiation
D4A92_RS02255	COG3485	protocatechuate 3,4-dioxygenase
D4A92_RS02260	COG3485	protocatechuate 3,4-dioxygenase
D4A92_RS02265	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D4A92_RS02270	COG2267	carboxylic ester hydrolase activity
D4A92_RS02275	COG0583	DNA-binding transcription factor activity
D4A92_RS02280	COG1414	Transcriptional regulator
D4A92_RS02290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D4A92_RS02305	COG5001	Diguanylate cyclase
D4A92_RS02305	COG3300	MHYT domain
D4A92_RS02310	COG3142	Participates in the control of copper homeostasis
D4A92_RS02330	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS02335	COG1737	Transcriptional regulator
D4A92_RS02380	COG3842	ATPase activity
D4A92_RS02390	COG0395	ABC-type sugar transport system, permease component
D4A92_RS02395	COG1175	transmembrane transport
D4A92_RS02400	COG0673	inositol 2-dehydrogenase activity
D4A92_RS02405	COG2188	Transcriptional regulator
D4A92_RS02410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D4A92_RS02415	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D4A92_RS02420	COG1940	carbohydrate kinase activity
D4A92_RS02440	COG0395	ABC-type sugar transport system, permease component
D4A92_RS02445	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS02455	COG3842	ATPase activity
D4A92_RS02465	COG2186	Transcriptional regulator
D4A92_RS02470	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS02475	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS02480	COG1129	ABC transporter
D4A92_RS02485	COG1879	ABC-type sugar transport system periplasmic component
D4A92_RS02530	COG1696	Membrane protein involved in D-alanine export
D4A92_RS02570	COG0835	chemotaxis
D4A92_RS02595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D4A92_RS02610	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D4A92_RS02620	COG1233	COG1233 Phytoene dehydrogenase and related
D4A92_RS02625	COG1562	ergosterol biosynthetic process
D4A92_RS02645	COG0142	geranyltranstransferase activity
D4A92_RS02650	COG0500	methyltransferase
D4A92_RS02655	COG1063	alcohol dehydrogenase
D4A92_RS02660	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D4A92_RS02665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D4A92_RS02670	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D4A92_RS02705	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D4A92_RS02710	COG0156	8-amino-7-oxononanoate synthase activity
D4A92_RS02720	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D4A92_RS02755	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D4A92_RS02760	COG1429	ligase activity, forming nitrogen-metal bonds
D4A92_RS02765	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D4A92_RS02770	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D4A92_RS02790	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D4A92_RS02795	COG2211	Major facilitator Superfamily
D4A92_RS02800	COG0644	oxidoreductase
D4A92_RS02810	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D4A92_RS02820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D4A92_RS02840	COG2188	Transcriptional regulator
D4A92_RS02850	COG4989	oxidoreductase activity
D4A92_RS02870	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D4A92_RS02875	COG2855	membrane
D4A92_RS02885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D4A92_RS02890	COG2218	PFAM glutamate synthase alpha subunit domain protein
D4A92_RS02895	COG0069	glutamate synthase activity
D4A92_RS02915	COG1175	transmembrane transport
D4A92_RS02930	COG0673	inositol 2-dehydrogenase activity
D4A92_RS02935	COG1609	Transcriptional regulator
D4A92_RS02965	COG3842	ATPase activity
D4A92_RS02970	COG1175	transmembrane transport
D4A92_RS02975	COG0395	ABC-type sugar transport system, permease component
D4A92_RS02990	COG4136	ATPase activity
D4A92_RS02995	COG4135	transport system, permease component
D4A92_RS03000	COG4134	Bacterial extracellular solute-binding protein
D4A92_RS03020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D4A92_RS03025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D4A92_RS03030	COG0583	DNA-binding transcription factor activity
D4A92_RS03050	COG0583	DNA-binding transcription factor activity
D4A92_RS03055	COG3485	protocatechuate 3,4-dioxygenase
D4A92_RS03085	COG4177	L-phenylalanine transmembrane transporter activity
D4A92_RS03095	COG3485	protocatechuate 3,4-dioxygenase
D4A92_RS03100	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
D4A92_RS03120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D4A92_RS03135	COG0601	transmembrane transport
D4A92_RS03145	COG0444	Belongs to the ABC transporter superfamily
D4A92_RS03150	COG1124	(ABC) transporter
D4A92_RS03160	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS03165	COG0183	Belongs to the thiolase family
D4A92_RS03200	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS03205	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D4A92_RS03215	COG2030	dehydratase
D4A92_RS03235	COG1178	ABC-type Fe3 transport system permease component
D4A92_RS03260	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D4A92_RS03270	COG2274	protein secretion by the type I secretion system
D4A92_RS03295	COG1032	radical SAM domain protein
D4A92_RS03325	COG2801	Transposase and inactivated derivatives
D4A92_RS03380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D4A92_RS03385	COG1309	transcriptional regulator
D4A92_RS03395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D4A92_RS03405	COG0789	Transcriptional regulator
D4A92_RS03410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D4A92_RS03420	COG0583	DNA-binding transcription factor activity
D4A92_RS03430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D4A92_RS03435	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D4A92_RS03440	COG1509	lysine 2,3-aminomutase activity
D4A92_RS03470	COG0546	phosphoglycolate phosphatase activity
D4A92_RS03470	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D4A92_RS03505	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D4A92_RS03515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D4A92_RS03530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS03535	COG1012	belongs to the aldehyde dehydrogenase family
D4A92_RS03550	COG0848	biopolymer transport protein
D4A92_RS03565	COG0307	riboflavin synthase, alpha
D4A92_RS03580	COG1285	pathogenesis
D4A92_RS03585	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS03605	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS03615	COG2373	Large extracellular alpha-helical protein
D4A92_RS03620	COG4953	penicillin-binding protein 1C
D4A92_RS03655	COG3932	Exopolysaccharide synthesis, ExoD
D4A92_RS03670	COG0670	Belongs to the BI1 family
D4A92_RS03675	COG4952	isomerase
D4A92_RS03685	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS03685	COG3347	Dehydrogenase
D4A92_RS03700	COG1129	ABC transporter
D4A92_RS03705	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS03710	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS03720	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D4A92_RS03725	COG0697	spore germination
D4A92_RS03730	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D4A92_RS03735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D4A92_RS03740	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
D4A92_RS03755	COG0277	FAD linked oxidase domain protein
D4A92_RS03760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A92_RS03765	COG2084	Dehydrogenase
D4A92_RS03770	COG0129	dihydroxy-acid dehydratase activity
D4A92_RS03780	COG0784	Response regulator, receiver
D4A92_RS03815	COG5002	protein histidine kinase activity
D4A92_RS03815	COG2176	DNA-directed DNA polymerase activity
D4A92_RS03825	COG0517	IMP dehydrogenase activity
D4A92_RS03830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D4A92_RS03850	COG0583	DNA-binding transcription factor activity
D4A92_RS03855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A92_RS03860	COG1116	anion transmembrane transporter activity
D4A92_RS03865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS03870	COG0402	S-adenosylhomocysteine deaminase activity
D4A92_RS03880	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4A92_RS03885	COG0251	oxidation-reduction process
D4A92_RS03930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D4A92_RS03945	COG1609	Transcriptional regulator
D4A92_RS03960	COG0673	inositol 2-dehydrogenase activity
D4A92_RS03970	COG1115	amino acid carrier protein
D4A92_RS03975	COG0471	metal ion transport
D4A92_RS03975	COG3273	potassium ion transport
D4A92_RS03985	COG4608	Belongs to the ABC transporter superfamily
D4A92_RS03990	COG0444	Belongs to the ABC transporter superfamily
D4A92_RS03995	COG0601	transmembrane transport
D4A92_RS04000	COG0747	negative chemotaxis
D4A92_RS04010	COG1388	LysM domain
D4A92_RS04010	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS04015	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D4A92_RS04020	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D4A92_RS04025	COG2080	2 iron, 2 sulfur cluster binding
D4A92_RS04085	COG0741	lytic transglycosylase activity
D4A92_RS04085	COG1196	nuclear chromosome segregation
D4A92_RS04085	COG0739	heme binding
D4A92_RS04090	COG0542	response to heat
D4A92_RS04100	COG2890	protein-(glutamine-N5) methyltransferase activity
D4A92_RS04105	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D4A92_RS04115	COG0527	aspartate kinase activity
D4A92_RS04120	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D4A92_RS04120	COG0392	lysyltransferase activity
D4A92_RS04130	COG4991	sh3 domain protein
D4A92_RS04135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D4A92_RS04155	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4A92_RS04160	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D4A92_RS04165	COG1040	competence protein
D4A92_RS04170	COG2226	methyltransferase
D4A92_RS04185	COG0494	nUDIX hydrolase
D4A92_RS04190	COG0456	acetyltransferase
D4A92_RS04195	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D4A92_RS04200	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D4A92_RS04205	COG0653	protein targeting
D4A92_RS04225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A92_RS04260	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D4A92_RS04270	COG0300	oxidoreductase activity
D4A92_RS04280	COG2096	Adenosyltransferase
D4A92_RS04290	COG2086	electron transfer activity
D4A92_RS04300	COG1250	3-hydroxyacyl-CoA dehydrogenase
D4A92_RS04310	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D4A92_RS04315	COG4208	sulfate ABC transporter
D4A92_RS04320	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D4A92_RS04325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A92_RS04330	COG0165	Argininosuccinate lyase
D4A92_RS04365	COG2884	Cell division ATP-binding protein ftsE
D4A92_RS04385	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D4A92_RS04395	COG0287	Prephenate dehydrogenase
D4A92_RS04400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D4A92_RS04405	COG2226	methyltransferase
D4A92_RS04410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A92_RS04435	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D4A92_RS04440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D4A92_RS04470	COG4536	flavin adenine dinucleotide binding
D4A92_RS04475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D4A92_RS04480	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D4A92_RS04490	COG4974	Belongs to the 'phage' integrase family
D4A92_RS04495	COG0825	malonyl-CoA metabolic process
D4A92_RS04500	COG3034	peptidoglycan biosynthetic process
D4A92_RS04505	COG0425	Belongs to the sulfur carrier protein TusA family
D4A92_RS04505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D4A92_RS04510	COG0523	cobalamin synthesis protein
D4A92_RS04515	COG1686	Belongs to the peptidase S11 family
D4A92_RS04520	COG1473	amidohydrolase
D4A92_RS04565	COG3685	Protein conserved in bacteria
D4A92_RS04580	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D4A92_RS04590	COG0156	8-amino-7-oxononanoate synthase activity
D4A92_RS04615	COG0729	surface antigen
D4A92_RS04630	COG0010	Belongs to the arginase family
D4A92_RS04640	COG0835	chemotaxis
D4A92_RS04645	COG0252	asparaginase activity
D4A92_RS04655	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D4A92_RS04660	COG3383	formate dehydrogenase (NAD+) activity
D4A92_RS04675	COG0583	DNA-binding transcription factor activity
D4A92_RS04680	COG0640	Transcriptional regulator
D4A92_RS04685	COG0039	L-malate dehydrogenase activity
D4A92_RS04695	COG1012	belongs to the aldehyde dehydrogenase family
D4A92_RS04700	COG4948	Mandelate Racemase Muconate Lactonizing
D4A92_RS04705	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D4A92_RS04710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D4A92_RS04715	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D4A92_RS04720	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D4A92_RS04725	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D4A92_RS04730	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D4A92_RS04750	COG4974	Belongs to the 'phage' integrase family
D4A92_RS04775	COG0300	oxidoreductase activity
D4A92_RS04790	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A92_RS04800	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D4A92_RS04805	COG0045	succinate-CoA ligase (ADP-forming) activity
D4A92_RS04810	COG0039	L-malate dehydrogenase activity
D4A92_RS04815	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
D4A92_RS04820	COG2845	Protein of unknown function (DUF459)
D4A92_RS04850	COG2264	protein methyltransferase activity
D4A92_RS04865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D4A92_RS04870	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D4A92_RS04875	COG0181	hydroxymethylbilane synthase activity
D4A92_RS04915	COG1872	DUF167
D4A92_RS04920	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D4A92_RS04930	COG1217	gtp-binding protein TYPA
D4A92_RS04935	COG0339	signal peptide processing
D4A92_RS04945	COG2814	Major facilitator Superfamily
D4A92_RS04950	COG0137	argininosuccinate synthase activity
D4A92_RS04960	COG3609	addiction module antidote protein, CC2985 family
D4A92_RS04965	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS04970	COG1280	lysine exporter protein (LysE YggA)
D4A92_RS04975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D4A92_RS04985	COG3339	Conserved Protein
D4A92_RS04990	COG2154	pterin-4-alpha-carbinolamine dehydratase
D4A92_RS04995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D4A92_RS05000	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D4A92_RS05010	COG4181	ATPase activity
D4A92_RS05020	COG0670	Belongs to the BI1 family
D4A92_RS05025	COG1329	Transcriptional regulator
D4A92_RS05030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
D4A92_RS05065	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS05075	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
D4A92_RS05085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D4A92_RS05090	COG0625	glutathione transferase activity
D4A92_RS05095	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D4A92_RS05100	COG0142	geranyltranstransferase activity
D4A92_RS05105	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D4A92_RS05115	COG2885	chlorophyll binding
D4A92_RS05120	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D4A92_RS05125	COG2223	nitrite transmembrane transporter activity
D4A92_RS05130	COG0697	spore germination
D4A92_RS05135	COG1473	amidohydrolase
D4A92_RS05140	COG1309	transcriptional regulator
D4A92_RS05145	COG3459	Glycosyltransferase 36 associated
D4A92_RS05150	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D4A92_RS05165	COG3046	protein related to deoxyribodipyrimidine photolyase
D4A92_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS05190	COG3842	ATPase activity
D4A92_RS05200	COG0395	ABC-type sugar transport system, permease component
D4A92_RS05205	COG1175	transmembrane transport
D4A92_RS05220	COG0246	Mannitol dehydrogenase
D4A92_RS05225	COG1802	Transcriptional regulator
D4A92_RS05230	COG2721	sulfolactate sulfo-lyase activity
D4A92_RS05245	COG1879	ABC-type sugar transport system periplasmic component
D4A92_RS05250	COG1129	ABC transporter
D4A92_RS05255	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS05260	COG1063	alcohol dehydrogenase
D4A92_RS05265	COG0400	carboxylic ester hydrolase activity
D4A92_RS05270	COG0346	lactoylglutathione lyase activity
D4A92_RS05280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D4A92_RS05280	COG0519	Catalyzes the synthesis of GMP from XMP
D4A92_RS05300	COG2188	Transcriptional regulator
D4A92_RS05305	COG3624	Phosphonate C-P lyase system protein PhnG
D4A92_RS05310	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
D4A92_RS05315	COG3626	phosphonate metabolism
D4A92_RS05320	COG3627	carbon phosphorus lyase activity
D4A92_RS05325	COG4107	phosphonate C-P lyase system protein PhnK
D4A92_RS05330	COG4778	phosphonate C-P lyase system protein PhnL
D4A92_RS05340	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
D4A92_RS05350	COG3639	organic phosphonate transmembrane transporter activity
D4A92_RS05355	COG3639	organic phosphonate transmembrane transporter activity
D4A92_RS05360	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D4A92_RS05365	COG3454	Phosphonate metabolism
D4A92_RS05370	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D4A92_RS05375	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D4A92_RS05380	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D4A92_RS05385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A92_RS05400	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D4A92_RS05405	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D4A92_RS05410	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D4A92_RS05415	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D4A92_RS05420	COG0799	negative regulation of ribosome biogenesis
D4A92_RS05425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D4A92_RS05435	COG0793	Belongs to the peptidase S41A family
D4A92_RS05445	COG0494	nUDIX hydrolase
D4A92_RS05475	COG0587	DNA-directed DNA polymerase activity
D4A92_RS05510	COG0488	(ABC) transporter
D4A92_RS05525	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
D4A92_RS05545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4A92_RS05550	COG0473	3-isopropylmalate dehydrogenase activity
D4A92_RS05555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D4A92_RS05560	COG0066	3-isopropylmalate dehydratase activity
D4A92_RS05580	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D4A92_RS05615	COG2835	tetraacyldisaccharide 4'-kinase activity
D4A92_RS05620	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D4A92_RS05625	COG1946	Acyl-CoA thioesterase
D4A92_RS05630	COG0347	Belongs to the P(II) protein family
D4A92_RS05635	COG0004	ammonium transporteR
D4A92_RS05640	COG1674	ftsk spoiiie
D4A92_RS05645	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D4A92_RS05660	COG0745	RESPONSE REGULATOR receiver
D4A92_RS05680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A92_RS05685	COG0765	amino acid transport
D4A92_RS05700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D4A92_RS05710	COG0335	large ribosomal subunit rRNA binding
D4A92_RS05720	COG0336	Belongs to the RNA methyltransferase TrmD family
D4A92_RS05725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D4A92_RS05730	COG0228	four-way junction DNA binding
D4A92_RS05735	COG0287	Prephenate dehydrogenase
D4A92_RS05735	COG1605	Chorismate mutase
D4A92_RS05740	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D4A92_RS05750	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D4A92_RS05765	COG2022	thiamine diphosphate biosynthetic process
D4A92_RS05775	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D4A92_RS05780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4A92_RS05785	COG0552	protein localization to endoplasmic reticulum
D4A92_RS05790	COG2917	probably involved in intracellular septation
D4A92_RS05810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4A92_RS05815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D4A92_RS05820	COG4133	protoheme IX ABC transporter activity
D4A92_RS05825	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D4A92_RS05835	COG0800	Aldolase
D4A92_RS05840	COG3734	2-keto-3-deoxy-galactonokinase
D4A92_RS05855	COG0129	dihydroxy-acid dehydratase activity
D4A92_RS05865	COG4214	carbohydrate transport
D4A92_RS05875	COG4213	ABC transporter substrate-binding protein
D4A92_RS05895	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D4A92_RS05905	COG0288	reversible hydration of carbon dioxide
D4A92_RS05920	COG2270	Major facilitator Superfamily
D4A92_RS05925	COG0138	bifunctional purine biosynthesis protein purh
D4A92_RS05935	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D4A92_RS05940	COG0501	Belongs to the peptidase M48B family
D4A92_RS05960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A92_RS05975	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D4A92_RS05980	COG0495	leucyl-tRNA aminoacylation
D4A92_RS06005	COG0357	Ribosomal RNA small subunit methyltransferase G
D4A92_RS06010	COG0445	tRNA wobble uridine modification
D4A92_RS06015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D4A92_RS06020	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D4A92_RS06025	COG1981	membrane
D4A92_RS06030	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D4A92_RS06035	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D4A92_RS06040	COG0424	maF-like protein
D4A92_RS06045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D4A92_RS06050	COG0237	dephospho-CoA kinase activity
D4A92_RS06060	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
D4A92_RS06085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D4A92_RS06115	COG0135	phosphoribosylanthranilate isomerase activity
D4A92_RS06120	COG0133	tryptophan synthase activity
D4A92_RS06125	COG0159	tryptophan synthase activity
D4A92_RS06130	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D4A92_RS06155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D4A92_RS06160	COG3178	'Phosphotransferase
D4A92_RS06165	COG2205	protein histidine kinase activity
D4A92_RS06170	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D4A92_RS06175	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A92_RS06180	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A92_RS06180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D4A92_RS06190	COG0642	Histidine kinase
D4A92_RS06195	COG0745	RESPONSE REGULATOR receiver
D4A92_RS06200	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D4A92_RS06215	COG1072	(Pantothenic acid kinase))
D4A92_RS06220	COG0140	phosphoribosyl-ATP diphosphatase activity
D4A92_RS06225	COG0107	imidazoleglycerol-phosphate synthase activity
D4A92_RS06230	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D4A92_RS06235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D4A92_RS06240	COG0131	Imidazoleglycerol-phosphate dehydratase
D4A92_RS06245	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D4A92_RS06250	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D4A92_RS06260	COG2124	cytochrome p450
D4A92_RS06270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D4A92_RS06275	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS06285	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
D4A92_RS06295	COG1643	Atp-dependent helicase
D4A92_RS06300	COG2423	ornithine cyclodeaminase activity
D4A92_RS06350	COG0517	IMP dehydrogenase activity
D4A92_RS06355	COG4974	Belongs to the 'phage' integrase family
D4A92_RS06380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A92_RS06385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A92_RS06390	COG4467	Involved in initiation control of chromosome replication
D4A92_RS06395	COG0517	IMP dehydrogenase activity
D4A92_RS06400	COG4974	Belongs to the 'phage' integrase family
D4A92_RS06405	COG4467	Involved in initiation control of chromosome replication
D4A92_RS06410	COG4467	Involved in initiation control of chromosome replication
D4A92_RS06415	COG0517	IMP dehydrogenase activity
D4A92_RS06420	COG4974	Belongs to the 'phage' integrase family
D4A92_RS06430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D4A92_RS06480	COG2610	gluconate transmembrane transporter activity
D4A92_RS06515	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS06525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS06540	COG4644	lycopene metabolic process
D4A92_RS06545	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS06555	COG0651	ATP synthesis coupled electron transport
D4A92_RS06560	COG0651	ATP synthesis coupled electron transport
D4A92_RS06565	COG0651	ATP synthesis coupled electron transport
D4A92_RS06580	COG1320	monovalent cation:proton antiporter activity
D4A92_RS06600	COG1285	pathogenesis
D4A92_RS06605	COG3932	Exopolysaccharide synthesis, ExoD
D4A92_RS06610	COG2801	Transposase and inactivated derivatives
D4A92_RS06615	COG0246	Mannitol dehydrogenase
D4A92_RS06620	COG1312	Catalyzes the dehydration of D-mannonate
D4A92_RS06625	COG1063	alcohol dehydrogenase
D4A92_RS06630	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D4A92_RS06640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D4A92_RS06645	COG2186	Transcriptional regulator
D4A92_RS06660	COG1454	alcohol dehydrogenase
D4A92_RS06665	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D4A92_RS06680	COG0747	negative chemotaxis
D4A92_RS06690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS06695	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS06700	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A92_RS06710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A92_RS06715	COG3842	ATPase activity
D4A92_RS06725	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS06745	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D4A92_RS06745	COG1648	precorrin-2 dehydrogenase activity
D4A92_RS06750	COG0243	molybdopterin cofactor binding
D4A92_RS06760	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D4A92_RS06765	COG1116	anion transmembrane transporter activity
D4A92_RS06770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS06775	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A92_RS06780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A92_RS06785	COG3707	response regulator
D4A92_RS06790	COG0477	Major facilitator Superfamily
D4A92_RS06795	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D4A92_RS06800	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D4A92_RS06805	COG1845	cytochrome c oxidase, subunit III
D4A92_RS06810	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D4A92_RS06840	COG2188	Transcriptional regulator
D4A92_RS06850	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D4A92_RS06860	COG2986	histidine ammonia-lyase
D4A92_RS06865	COG1228	amidohydrolase
D4A92_RS06870	COG2986	histidine ammonia-lyase
D4A92_RS06875	COG0402	S-adenosylhomocysteine deaminase activity
D4A92_RS06880	COG1069	ribulokinase activity
D4A92_RS06885	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A92_RS06905	COG0395	ABC-type sugar transport system, permease component
D4A92_RS06910	COG1175	transmembrane transport
D4A92_RS06920	COG2390	Transcriptional regulator
D4A92_RS06930	COG1252	NADH dehydrogenase
D4A92_RS06935	COG1120	ATPase activity
D4A92_RS06945	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS06960	COG3842	ATPase activity
D4A92_RS06965	COG3842	ATPase activity
D4A92_RS06975	COG0395	ABC-type sugar transport system, permease component
D4A92_RS06995	COG1793	dna ligase
D4A92_RS07010	COG3806	Anti-sigma factor
D4A92_RS07015	COG1595	DNA-templated transcription, initiation
D4A92_RS07020	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D4A92_RS07030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D4A92_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS07040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D4A92_RS07045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A92_RS07070	COG0539	negative regulation of cytoplasmic translation
D4A92_RS07075	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D4A92_RS07105	COG2860	membrane
D4A92_RS07115	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D4A92_RS07125	COG2197	response regulator
D4A92_RS07140	COG1185	polyribonucleotide nucleotidyltransferase activity
D4A92_RS07145	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D4A92_RS07150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D4A92_RS07155	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D4A92_RS07165	COG3064	Membrane
D4A92_RS07165	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D4A92_RS07175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D4A92_RS07175	COG0195	Participates in both transcription termination and antitermination
D4A92_RS07180	COG0779	Required for maturation of 30S ribosomal subunits
D4A92_RS07185	COG2814	Major facilitator Superfamily
D4A92_RS07195	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D4A92_RS07200	COG2258	MOSC domain
D4A92_RS07210	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D4A92_RS07215	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D4A92_RS07230	COG2816	NAD+ diphosphatase activity
D4A92_RS07235	COG0077	Prephenate dehydratase
D4A92_RS07235	COG1605	Chorismate mutase
D4A92_RS07240	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D4A92_RS07245	COG3474	cytochrome
D4A92_RS07255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A92_RS07280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D4A92_RS07290	COG2900	Belongs to the SlyX family
D4A92_RS07305	COG0484	heat shock protein binding
D4A92_RS07315	COG0443	Heat shock 70 kDa protein
D4A92_RS07320	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D4A92_RS07325	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D4A92_RS07340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A92_RS07340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D4A92_RS07350	COG0588	phosphoglycerate mutase activity
D4A92_RS07355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D4A92_RS07360	COG1132	(ABC) transporter
D4A92_RS07365	COG0837	glucose binding
D4A92_RS07370	COG1803	Methylglyoxal synthase
D4A92_RS07375	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
D4A92_RS07380	COG4166	transmembrane transport
D4A92_RS07385	COG4174	ABC transporter (Permease)
D4A92_RS07390	COG4239	(ABC) transporter, permease
D4A92_RS07405	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS07420	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D4A92_RS07460	COG4964	Belongs to the GSP D family
D4A92_RS07495	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D4A92_RS07500	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D4A92_RS07505	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D4A92_RS07515	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D4A92_RS07520	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D4A92_RS07535	COG1079	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS07540	COG1079	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS07545	COG3845	ABC transporter
D4A92_RS07550	COG1744	ABC transporter substrate-binding protein PnrA-like
D4A92_RS07555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4A92_RS07595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D4A92_RS07605	COG0583	DNA-binding transcription factor activity
D4A92_RS07630	COG1569	PIN domain
D4A92_RS07635	COG3311	Transcriptional regulator
D4A92_RS07640	COG0210	DNA helicase
D4A92_RS07715	COG3622	Belongs to the hyi family
D4A92_RS07720	COG0668	transmembrane transport
D4A92_RS07725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D4A92_RS07725	COG0574	Belongs to the PEP-utilizing enzyme family
D4A92_RS07730	COG1309	transcriptional regulator
D4A92_RS07735	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D4A92_RS07740	COG1082	Xylose isomerase domain protein TIM barrel
D4A92_RS07740	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D4A92_RS07750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D4A92_RS07760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
D4A92_RS07765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A92_RS07780	COG1126	abc transporter atp-binding protein
D4A92_RS07785	COG0765	amino acid transport
D4A92_RS07810	COG1363	Peptidase, m42
D4A92_RS07835	COG0367	asparagine synthase
D4A92_RS07840	COG2918	glutathione biosynthetic process
D4A92_RS07840	COG0189	ligase activity
D4A92_RS07875	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D4A92_RS07885	COG0791	NLP P60 protein
D4A92_RS07945	COG3422	double-strand break repair
D4A92_RS07970	COG0481	GTPase activity
D4A92_RS07975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4A92_RS08000	COG4529	Protein conserved in bacteria
D4A92_RS08010	COG1063	alcohol dehydrogenase
D4A92_RS08015	COG0156	8-amino-7-oxononanoate synthase activity
D4A92_RS08050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D4A92_RS08075	COG2271	Major facilitator Superfamily
D4A92_RS08090	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D4A92_RS08095	COG4191	Histidine kinase
D4A92_RS08100	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D4A92_RS08105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D4A92_RS08115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D4A92_RS08125	COG0072	phenylalanine-tRNA ligase activity
D4A92_RS08125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4A92_RS08135	COG1162	GTPase activity
D4A92_RS08150	COG1120	ATPase activity
D4A92_RS08155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS08165	COG1725	Transcriptional regulator
D4A92_RS08170	COG0697	spore germination
D4A92_RS08175	COG0667	Aldo Keto reductase
D4A92_RS08180	COG0667	Aldo Keto reductase
D4A92_RS08185	COG4977	sequence-specific DNA binding
D4A92_RS08215	COG1570	exodeoxyribonuclease VII activity
D4A92_RS08220	COG2249	NAD(P)H dehydrogenase (quinone) activity
D4A92_RS08225	COG1278	Cold shock
D4A92_RS08250	COG2309	aminopeptidase activity
D4A92_RS08255	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D4A92_RS08260	COG1393	Belongs to the ArsC family
D4A92_RS08265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D4A92_RS08270	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D4A92_RS08270	COG0519	Catalyzes the synthesis of GMP from XMP
D4A92_RS08320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D4A92_RS08330	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D4A92_RS08340	COG1968	undecaprenyl-diphosphatase activity
D4A92_RS08360	COG0284	orotidine-5'-phosphate decarboxylase activity
D4A92_RS08370	COG3963	phosphatidate phosphatase activity
D4A92_RS08380	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D4A92_RS08385	COG0792	nuclease activity
D4A92_RS08395	COG1175	transmembrane transport
D4A92_RS08400	COG0395	ABC-type sugar transport system, permease component
D4A92_RS08405	COG3842	ATPase activity
D4A92_RS08410	COG0189	ligase activity
D4A92_RS08420	COG3920	Histidine kinase
D4A92_RS08435	COG1280	lysine exporter protein (LysE YggA)
D4A92_RS08445	COG0756	dUTP diphosphatase activity
D4A92_RS08450	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D4A92_RS08455	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A92_RS08460	COG0351	phosphomethylpyrimidine kinase
D4A92_RS08470	COG1741	Belongs to the pirin family
D4A92_RS08485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D4A92_RS08490	COG3920	Histidine kinase
D4A92_RS08495	COG3437	response regulator, receiver
D4A92_RS08500	COG5002	protein histidine kinase activity
D4A92_RS08500	COG0784	Response regulator, receiver
D4A92_RS08500	COG2198	Histidine kinase
D4A92_RS08505	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D4A92_RS08510	COG2226	methyltransferase
D4A92_RS08515	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D4A92_RS08520	COG1024	Enoyl-CoA hydratase
D4A92_RS08525	COG0268	Binds directly to 16S ribosomal RNA
D4A92_RS08530	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D4A92_RS08535	COG2226	methyltransferase
D4A92_RS08540	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4A92_RS08545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D4A92_RS08555	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D4A92_RS08560	COG1420	regulation of RNA biosynthetic process
D4A92_RS08565	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D4A92_RS08570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D4A92_RS08575	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D4A92_RS08585	COG1137	ATPase activity
D4A92_RS08590	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
D4A92_RS08600	COG0776	regulation of translation
D4A92_RS08610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D4A92_RS08610	COG0116	Belongs to the methyltransferase superfamily
D4A92_RS08615	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4A92_RS08620	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D4A92_RS08635	COG0281	malic enzyme
D4A92_RS08635	COG0280	phosphate acetyltransferase
D4A92_RS08640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D4A92_RS08645	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D4A92_RS08665	COG0180	Tryptophanyl-tRNA synthetase
D4A92_RS08675	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D4A92_RS08700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D4A92_RS08705	COG1702	phosphate starvation-inducible protein PhoH
D4A92_RS08710	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D4A92_RS08720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D4A92_RS08725	COG1396	sequence-specific DNA binding
D4A92_RS08730	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D4A92_RS08735	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D4A92_RS08745	COG0071	Belongs to the small heat shock protein (HSP20) family
D4A92_RS08755	COG0840	transmembrane signaling receptor activity
D4A92_RS08760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A92_RS08770	COG0840	transmembrane signaling receptor activity
D4A92_RS08775	COG0840	transmembrane signaling receptor activity
D4A92_RS08780	COG0242	peptide deformylase activity
D4A92_RS08785	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D4A92_RS08790	COG0101	tRNA pseudouridine synthase activity
D4A92_RS08800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D4A92_RS08810	COG2171	N-acyltransferase activity
D4A92_RS08835	COG0477	Major facilitator Superfamily
D4A92_RS08840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D4A92_RS08855	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D4A92_RS08860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D4A92_RS08870	COG0706	membrane insertase activity
D4A92_RS08875	COG0594	ribonuclease P activity
D4A92_RS08880	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D4A92_RS08885	COG5002	protein histidine kinase activity
D4A92_RS08895	COG3938	Belongs to the proline racemase family
D4A92_RS08900	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D4A92_RS08930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D4A92_RS08955	COG0418	dihydroorotase activity
D4A92_RS08965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D4A92_RS08985	COG0166	Belongs to the GPI family
D4A92_RS08990	COG0318	PFAM AMP-dependent synthetase and ligase
D4A92_RS09020	COG2326	polyphosphate kinase activity
D4A92_RS09025	COG5002	protein histidine kinase activity
D4A92_RS09035	COG0573	inorganic phosphate transmembrane transporter activity
D4A92_RS09045	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D4A92_RS09050	COG0704	Plays a role in the regulation of phosphate uptake
D4A92_RS09055	COG0745	RESPONSE REGULATOR receiver
D4A92_RS09065	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D4A92_RS09070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D4A92_RS09075	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D4A92_RS09085	COG2967	ApaG domain
D4A92_RS09095	COG0717	Belongs to the dCTP deaminase family
D4A92_RS09150	COG0167	dihydroorotate dehydrogenase activity
D4A92_RS09155	COG0534	Mate efflux family protein
D4A92_RS09180	COG1201	RNA secondary structure unwinding
D4A92_RS09195	COG0730	response to heat
D4A92_RS09205	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS09210	COG0183	Belongs to the thiolase family
D4A92_RS09215	COG1250	3-hydroxyacyl-CoA dehydrogenase
D4A92_RS09215	COG1024	Enoyl-CoA hydratase
D4A92_RS09220	COG0584	glycerophosphoryl diester phosphodiesterase
D4A92_RS09235	COG2198	Histidine kinase
D4A92_RS09235	COG2205	protein histidine kinase activity
D4A92_RS09235	COG0784	Response regulator, receiver
D4A92_RS09240	COG1970	mechanosensitive ion channel activity
D4A92_RS09245	COG0436	Aminotransferase
D4A92_RS09255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D4A92_RS09260	COG1129	ABC transporter
D4A92_RS09260	COG0842	Transport permease protein
D4A92_RS09265	COG0842	Transport permease protein
D4A92_RS09270	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D4A92_RS09350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D4A92_RS09360	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D4A92_RS09365	COG5328	Belongs to the UPF0262 family
D4A92_RS09375	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D4A92_RS09380	COG0424	maF-like protein
D4A92_RS09385	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
D4A92_RS09425	COG3299	homolog of phage Mu protein gp47
D4A92_RS09500	COG4397	Mu-like prophage major head subunit gpT
D4A92_RS09525	COG4383	Mu-like prophage protein gp29
D4A92_RS09530	COG4373	Mu-like prophage FluMu protein gp28
D4A92_RS09610	COG3750	Belongs to the UPF0335 family
D4A92_RS09640	COG2842	Transposition protein
D4A92_RS09705	COG0747	negative chemotaxis
D4A92_RS09710	COG0601	transmembrane transport
D4A92_RS09715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS09720	COG0444	Belongs to the ABC transporter superfamily
D4A92_RS09725	COG4608	Belongs to the ABC transporter superfamily
D4A92_RS09735	COG1448	Aminotransferase
D4A92_RS09750	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS09755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A92_RS09775	COG1733	regulation of RNA biosynthetic process
D4A92_RS09795	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS09800	COG1129	ABC transporter
D4A92_RS09805	COG1879	ABC-type sugar transport system periplasmic component
D4A92_RS09810	COG4585	Histidine kinase
D4A92_RS09820	COG2137	regulation of response to DNA damage stimulus
D4A92_RS09845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D4A92_RS09850	COG3618	amidohydrolase
D4A92_RS09855	COG4948	Mandelate Racemase Muconate Lactonizing
D4A92_RS09860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A92_RS09865	COG2186	Transcriptional regulator
D4A92_RS09870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D4A92_RS09885	COG2274	protein secretion by the type I secretion system
D4A92_RS09915	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A92_RS09915	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A92_RS09925	COG0297	glycogen (starch) synthase activity
D4A92_RS09940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4A92_RS09975	COG1012	belongs to the aldehyde dehydrogenase family
D4A92_RS09990	COG1024	Enoyl-CoA hydratase
D4A92_RS10000	COG4770	biotin carboxylase activity
D4A92_RS10005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D4A92_RS10010	COG4336	lyase activity
D4A92_RS10015	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D4A92_RS10020	COG1914	H( )-stimulated, divalent metal cation uptake system
D4A92_RS10025	COG1802	Transcriptional regulator
D4A92_RS10030	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS10035	COG1607	acyl-coa hydrolase
D4A92_RS10055	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D4A92_RS10100	COG0297	glycogen (starch) synthase activity
D4A92_RS10110	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D4A92_RS10125	COG0840	transmembrane signaling receptor activity
D4A92_RS10135	COG0745	RESPONSE REGULATOR receiver
D4A92_RS10140	COG2198	Histidine kinase
D4A92_RS10140	COG0643	Histidine kinase
D4A92_RS10145	COG0835	chemotaxis
D4A92_RS10150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D4A92_RS10155	COG2201	protein-glutamate methylesterase activity
D4A92_RS10160	COG0745	RESPONSE REGULATOR receiver
D4A92_RS10165	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D4A92_RS10175	COG1766	The M ring may be actively involved in energy transduction
D4A92_RS10180	COG2771	luxR family
D4A92_RS10195	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4A92_RS10200	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A92_RS10205	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A92_RS10210	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A92_RS10215	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D4A92_RS10220	COG4786	Flagellar basal body rod
D4A92_RS10225	COG1157	protein secretion by the type III secretion system
D4A92_RS10235	COG1815	bacterial-type flagellum-dependent cell motility
D4A92_RS10240	COG1558	bacterial-type flagellum-dependent cell motility
D4A92_RS10245	COG1677	Flagellar hook-basal body complex protein FliE
D4A92_RS10250	COG4786	Flagellar basal body rod
D4A92_RS10255	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
D4A92_RS10260	COG1706	bacterial-type flagellum-dependent cell motility
D4A92_RS10270	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
D4A92_RS10280	COG1338	Plays a role in the flagellum-specific transport system
D4A92_RS10295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A92_RS10300	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A92_RS10310	COG1360	Flagellar Motor Protein
D4A92_RS10335	COG1749	Flagellar hook protein flgE
D4A92_RS10340	COG4786	Flagellar basal body rod
D4A92_RS10340	COG1256	bacterial-type flagellum assembly
D4A92_RS10355	COG5443	negative regulation of bacterial-type flagellum assembly
D4A92_RS10360	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D4A92_RS10365	COG4794	Type iii secretion
D4A92_RS10370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D4A92_RS10405	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D4A92_RS10410	COG1609	Transcriptional regulator
D4A92_RS10415	COG1653	transport
D4A92_RS10420	COG1175	transmembrane transport
D4A92_RS10425	COG0395	ABC-type sugar transport system, permease component
D4A92_RS10430	COG0366	Alpha amylase catalytic
D4A92_RS10435	COG3842	ATPase activity
D4A92_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS10465	COG1595	DNA-templated transcription, initiation
D4A92_RS10480	COG0129	dihydroxy-acid dehydratase activity
D4A92_RS10485	COG0363	glucosamine-6-phosphate deaminase activity
D4A92_RS10490	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D4A92_RS10500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS10510	COG2081	HI0933 family
D4A92_RS10520	COG0840	transmembrane signaling receptor activity
D4A92_RS10520	COG2972	Histidine kinase
D4A92_RS10540	COG2224	Isocitrate lyase
D4A92_RS10550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D4A92_RS10555	COG3842	ATPase activity
D4A92_RS10560	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS10565	COG1177	transmembrane transport
D4A92_RS10580	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D4A92_RS10585	COG1178	ABC-type Fe3 transport system permease component
D4A92_RS10595	COG2205	protein histidine kinase activity
D4A92_RS10615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A92_RS10630	COG1959	2 iron, 2 sulfur cluster binding
D4A92_RS10650	COG4269	membrane
D4A92_RS10660	COG1840	ABC-type Fe3 transport system, periplasmic component
D4A92_RS10665	COG1959	2 iron, 2 sulfur cluster binding
D4A92_RS10675	COG3265	gluconokinase activity
D4A92_RS10685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS10690	COG0174	glutamine synthetase
D4A92_RS10695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS10700	COG2832	Protein of unknown function (DUF454)
D4A92_RS10705	COG5001	Diguanylate cyclase
D4A92_RS10730	COG1120	ATPase activity
D4A92_RS10735	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS10740	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS10745	COG4592	Periplasmic binding protein
D4A92_RS10750	COG4774	siderophore transport
D4A92_RS10765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D4A92_RS10780	COG1609	Transcriptional regulator
D4A92_RS10790	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS10795	COG3833	ABC-type maltose transport systems, permease component
D4A92_RS10800	COG3842	ATPase activity
D4A92_RS10810	COG0483	inositol monophosphate 1-phosphatase activity
D4A92_RS10815	COG3842	ATPase activity
D4A92_RS10820	COG0395	ABC-type sugar transport system, permease component
D4A92_RS10825	COG1175	transmembrane transport
D4A92_RS10830	COG1653	transport
D4A92_RS10850	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A92_RS10850	COG2111	Na H antiporter
D4A92_RS10855	COG1006	Multisubunit Na H antiporter MnhC subunit
D4A92_RS10860	COG0651	ATP synthesis coupled electron transport
D4A92_RS10865	COG1863	multisubunit Na H antiporter MnhE subunit
D4A92_RS10870	COG2212	antiporter activity
D4A92_RS10875	COG1320	monovalent cation:proton antiporter activity
D4A92_RS10895	COG4771	TonB-dependent receptor
D4A92_RS10900	COG2204	response regulator
D4A92_RS10905	COG4191	Histidine kinase
D4A92_RS10910	COG1320	monovalent cation:proton antiporter activity
D4A92_RS10925	COG0651	ATP synthesis coupled electron transport
D4A92_RS10930	COG1006	Multisubunit Na H antiporter MnhC subunit
D4A92_RS10935	COG2111	Na H antiporter
D4A92_RS10940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A92_RS10940	COG2111	Na H antiporter
D4A92_RS10955	COG4191	Histidine kinase
D4A92_RS10955	COG0784	Response regulator, receiver
D4A92_RS10965	COG3685	Protein conserved in bacteria
D4A92_RS10970	COG0753	catalase activity
D4A92_RS10995	COG0628	permease
D4A92_RS11010	COG1840	ABC-type Fe3 transport system, periplasmic component
D4A92_RS11015	COG1840	ABC-type Fe3 transport system, periplasmic component
D4A92_RS11025	COG3842	ATPase activity
D4A92_RS11035	COG3550	peptidyl-serine autophosphorylation
D4A92_RS11040	COG1396	sequence-specific DNA binding
D4A92_RS11070	COG0438	transferase activity, transferring glycosyl groups
D4A92_RS11090	COG4191	Histidine kinase
D4A92_RS11090	COG0784	Response regulator, receiver
D4A92_RS11095	COG3920	Histidine kinase
D4A92_RS11125	COG0668	transmembrane transport
D4A92_RS11135	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A92_RS11165	COG2205	protein histidine kinase activity
D4A92_RS11170	COG0745	RESPONSE REGULATOR receiver
D4A92_RS11180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D4A92_RS11190	COG1959	2 iron, 2 sulfur cluster binding
D4A92_RS11195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D4A92_RS11200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS11210	COG1116	anion transmembrane transporter activity
D4A92_RS11220	COG0248	Ppx GppA phosphatase
D4A92_RS11225	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D4A92_RS11235	COG0477	Major facilitator Superfamily
D4A92_RS11265	COG0412	Dienelactone hydrolase
D4A92_RS11290	COG0583	DNA-binding transcription factor activity
D4A92_RS11300	COG0840	transmembrane signaling receptor activity
D4A92_RS11300	COG0840	transmembrane signaling receptor activity
D4A92_RS11320	COG0306	phosphate transporter
D4A92_RS11330	COG0561	phosphatase activity
D4A92_RS11335	COG0438	transferase activity, transferring glycosyl groups
D4A92_RS11345	COG1139	Iron-sulfur cluster binding protein
D4A92_RS11350	COG0247	lactate metabolic process
D4A92_RS11355	COG2186	Transcriptional regulator
D4A92_RS11370	COG0583	DNA-binding transcription factor activity
D4A92_RS11375	COG0277	FAD linked oxidase domain protein
D4A92_RS11380	COG0277	FAD linked oxidase domain protein
D4A92_RS11390	COG0247	lactate metabolic process
D4A92_RS11400	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS11405	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS11410	COG2818	Glycosylase
D4A92_RS11445	COG0124	histidyl-tRNA synthetase
D4A92_RS11450	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D4A92_RS11455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D4A92_RS11460	COG2259	Doxx family
D4A92_RS11465	COG0625	glutathione transferase activity
D4A92_RS11480	COG0459	protein refolding
D4A92_RS11485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D4A92_RS11500	COG0196	riboflavin kinase activity
D4A92_RS11525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D4A92_RS11535	COG0456	acetyltransferase
D4A92_RS11545	COG0590	tRNA wobble adenosine to inosine editing
D4A92_RS11550	COG1187	pseudouridine synthase activity
D4A92_RS11555	COG0742	ribosomal rna small subunit methyltransferase
D4A92_RS11565	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D4A92_RS11565	COG0475	glutathione-regulated potassium exporter activity
D4A92_RS11570	COG0312	modulator of DNA gyrase
D4A92_RS11585	COG1519	Transferase
D4A92_RS11595	COG1663	tetraacyldisaccharide 4'-kinase activity
D4A92_RS11605	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D4A92_RS11610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A92_RS11610	COG2205	protein histidine kinase activity
D4A92_RS11615	COG3300	MHYT domain
D4A92_RS11615	COG5001	Diguanylate cyclase
D4A92_RS11620	COG0583	DNA-binding transcription factor activity
D4A92_RS11625	COG5598	trimethylamine methyltransferase
D4A92_RS11630	COG0446	pyridine nucleotide-disulphide oxidoreductase
D4A92_RS11630	COG1902	pentaerythritol trinitrate reductase activity
D4A92_RS11640	COG3386	PFAM SMP-30 Gluconolaconase
D4A92_RS11645	COG2197	response regulator
D4A92_RS11650	COG0489	protein tyrosine kinase activity
D4A92_RS11655	COG0598	Magnesium transport protein CorA
D4A92_RS11660	COG3158	transport of potassium into the cell
D4A92_RS11680	COG0356	it plays a direct role in the translocation of protons across the membrane
D4A92_RS11690	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D4A92_RS11695	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D4A92_RS11700	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D4A92_RS11715	COG0521	Mo-molybdopterin cofactor biosynthetic process
D4A92_RS11720	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D4A92_RS11730	COG0142	geranyltranstransferase activity
D4A92_RS11760	COG0752	glycyl-tRNA synthetase alpha subunit
D4A92_RS11770	COG2205	protein histidine kinase activity
D4A92_RS11770	COG2202	Pas domain
D4A92_RS11775	COG1704	LemA family
D4A92_RS11780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D4A92_RS11800	COG0751	glycine-tRNA ligase activity
D4A92_RS11815	COG1683	Conserved Protein
D4A92_RS11820	COG0840	transmembrane signaling receptor activity
D4A92_RS11830	COG0151	Belongs to the GarS family
D4A92_RS11835	COG2183	response to ionizing radiation
D4A92_RS11840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D4A92_RS11850	COG2514	catechol 2,3-dioxygenase activity
D4A92_RS11865	COG3909	cytochrome
D4A92_RS11870	COG2010	Cytochrome c
D4A92_RS11880	COG0693	protein deglycase activity
D4A92_RS11895	COG0789	Transcriptional regulator
D4A92_RS11915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D4A92_RS11920	COG3713	MltA-interacting MipA family protein
D4A92_RS11940	COG0725	ABC transporter, periplasmic molybdate-binding protein
D4A92_RS11945	COG4149	molybdate abc transporter
D4A92_RS11950	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
D4A92_RS11955	COG3585	molybdate ion transport
D4A92_RS11955	COG2005	Transcriptional regulator
D4A92_RS11965	COG0009	L-threonylcarbamoyladenylate synthase
D4A92_RS11980	COG4638	Rieske (2fe-2S)
D4A92_RS12000	COG0850	regulation of cytokinetic process
D4A92_RS12005	COG2894	cell division
D4A92_RS12010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D4A92_RS12020	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS12045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D4A92_RS12055	COG0840	transmembrane signaling receptor activity
D4A92_RS12065	COG0123	including yeast histone deacetylase and acetoin utilization protein
D4A92_RS12070	COG1722	exodeoxyribonuclease VII activity
D4A92_RS12080	COG2040	homocysteine
D4A92_RS12095	COG4215	(ABC) transporter
D4A92_RS12110	COG1522	sequence-specific DNA binding
D4A92_RS12115	COG2358	TRAP transporter, solute receptor (TAXI family
D4A92_RS12135	COG2610	gluconate transmembrane transporter activity
D4A92_RS12140	COG1741	Belongs to the pirin family
D4A92_RS12145	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D4A92_RS12175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D4A92_RS12200	COG1268	BioY protein
D4A92_RS12205	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D4A92_RS12210	COG1122	ATPase activity
D4A92_RS12215	COG3214	Protein conserved in bacteria
D4A92_RS12235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4A92_RS12235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D4A92_RS12240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D4A92_RS12260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D4A92_RS12270	COG0484	heat shock protein binding
D4A92_RS12280	COG0259	pyridoxamine-phosphate oxidase activity
D4A92_RS12290	COG2814	Major facilitator Superfamily
D4A92_RS12295	COG0789	Transcriptional regulator
D4A92_RS12300	COG1686	Belongs to the peptidase S11 family
D4A92_RS12315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A92_RS12320	COG0312	modulator of DNA gyrase
D4A92_RS12335	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D4A92_RS12340	COG0109	protoheme IX farnesyltransferase activity
D4A92_RS12345	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
D4A92_RS12360	COG3346	SURF1 family
D4A92_RS12370	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D4A92_RS12380	COG2203	Gaf domain
D4A92_RS12380	COG4251	negative regulation of phosphorylation
D4A92_RS12380	COG5001	Diguanylate cyclase
D4A92_RS12380	COG3706	GGDEF domain
D4A92_RS12385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D4A92_RS12390	COG0328	RNA-DNA hybrid ribonuclease activity
D4A92_RS12400	COG0678	peroxiredoxin activity
D4A92_RS12400	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D4A92_RS12410	COG1678	Uncharacterized ACR, COG1678
D4A92_RS12415	COG5001	Diguanylate cyclase
D4A92_RS12420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A92_RS12425	COG0612	Peptidase, M16
D4A92_RS12455	COG1597	lipid kinase activity
D4A92_RS12460	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A92_RS12505	COG1268	BioY protein
D4A92_RS12525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D4A92_RS12530	COG1396	sequence-specific DNA binding
D4A92_RS12535	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D4A92_RS12545	COG1194	a g-specific adenine glycosylase
D4A92_RS12555	COG0659	secondary active sulfate transmembrane transporter activity
D4A92_RS12590	COG1196	nuclear chromosome segregation
D4A92_RS12605	COG0738	Major facilitator superfamily
D4A92_RS12615	COG2514	catechol 2,3-dioxygenase activity
D4A92_RS12620	COG0574	Belongs to the PEP-utilizing enzyme family
D4A92_RS12620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D4A92_RS12665	COG0693	protein deglycase activity
D4A92_RS12675	COG1132	(ABC) transporter
D4A92_RS12680	COG4604	ABC transporter, ATP-binding protein
D4A92_RS12685	COG4605	iron ion homeostasis
D4A92_RS12690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS12710	COG1595	DNA-templated transcription, initiation
D4A92_RS12740	COG1609	Transcriptional regulator
D4A92_RS12755	COG2895	sulfate adenylyltransferase (ATP) activity
D4A92_RS12760	COG0175	sulfate reduction
D4A92_RS12765	COG0175	sulfate reduction
D4A92_RS12770	COG1959	2 iron, 2 sulfur cluster binding
D4A92_RS12800	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D4A92_RS12805	COG0659	secondary active sulfate transmembrane transporter activity
D4A92_RS12870	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
D4A92_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
D4A92_RS12890	COG1309	transcriptional regulator
D4A92_RS12895	COG4943	cyclic-guanylate-specific phosphodiesterase activity
D4A92_RS12905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D4A92_RS12995	COG0477	Major facilitator Superfamily
D4A92_RS13000	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS13005	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS13030	COG1846	Transcriptional regulator
D4A92_RS13035	COG1764	response to oxidative stress
D4A92_RS13070	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D4A92_RS13075	COG1278	Cold shock
D4A92_RS13090	COG3239	Fatty acid desaturase
D4A92_RS13105	COG0456	acetyltransferase
D4A92_RS13120	COG1742	UPF0060 membrane protein
D4A92_RS13130	COG0433	COG0433 Predicted ATPase
D4A92_RS13155	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS13160	COG3920	Histidine kinase
D4A92_RS13170	COG2323	membrane
D4A92_RS13185	COG1238	metal cluster binding
D4A92_RS13200	COG4106	trans-aconitate 2-methyltransferase activity
D4A92_RS13225	COG1879	ABC-type sugar transport system periplasmic component
D4A92_RS13230	COG4214	carbohydrate transport
D4A92_RS13235	COG1129	ABC transporter
D4A92_RS13240	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D4A92_RS13250	COG0840	transmembrane signaling receptor activity
D4A92_RS13250	COG2972	Histidine kinase
D4A92_RS13255	COG3788	relative of glutathione S-transferase, MAPEG superfamily
D4A92_RS13260	COG1272	protein, Hemolysin III
D4A92_RS13280	COG2130	NADP-dependent
D4A92_RS13305	COG0514	ATP-dependent DNA helicase (RecQ)
D4A92_RS13330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D4A92_RS13335	COG2111	Na H antiporter
D4A92_RS13335	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D4A92_RS13340	COG2111	Na H antiporter
D4A92_RS13345	COG1006	Multisubunit Na H antiporter MnhC subunit
D4A92_RS13350	COG0651	ATP synthesis coupled electron transport
D4A92_RS13355	COG1863	multisubunit Na H antiporter MnhE subunit
D4A92_RS13360	COG2212	antiporter activity
D4A92_RS13365	COG1320	monovalent cation:proton antiporter activity
D4A92_RS13370	COG4957	zinc ion binding
D4A92_RS13385	COG2166	iron-sulfur cluster assembly
D4A92_RS13405	COG2205	protein histidine kinase activity
D4A92_RS13515	COG2264	protein methyltransferase activity
D4A92_RS13545	COG5001	Diguanylate cyclase
D4A92_RS13545	COG3300	MHYT domain
D4A92_RS13550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D4A92_RS13555	COG2983	Belongs to the UPF0260 family
D4A92_RS13565	COG0789	Transcriptional regulator
D4A92_RS13575	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D4A92_RS13595	COG2852	Protein conserved in bacteria
D4A92_RS13600	COG3179	chitinase
D4A92_RS13615	COG4695	Portal protein
D4A92_RS13775	COG4235	cytochrome complex assembly
D4A92_RS13780	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
D4A92_RS13785	COG1138	Cytochrome C-type biogenesis protein
D4A92_RS13790	COG3088	subunit of a heme lyase
D4A92_RS13805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D4A92_RS13810	COG0745	RESPONSE REGULATOR receiver
D4A92_RS13815	COG2205	protein histidine kinase activity
D4A92_RS13820	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D4A92_RS13825	COG2205	protein histidine kinase activity
D4A92_RS13825	COG2202	Pas domain
D4A92_RS13830	COG0308	aminopeptidase N
D4A92_RS13835	COG0840	transmembrane signaling receptor activity
D4A92_RS13835	COG3290	protein histidine kinase activity
D4A92_RS13870	COG0443	Heat shock 70 kDa protein
D4A92_RS13890	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS13900	COG2084	Dehydrogenase
D4A92_RS13915	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS13920	COG1733	regulation of RNA biosynthetic process
D4A92_RS13930	COG1522	sequence-specific DNA binding
D4A92_RS13940	COG2814	Major facilitator Superfamily
D4A92_RS13950	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS13955	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS13960	COG0601	transmembrane transport
D4A92_RS13970	COG0174	glutamine synthetase
D4A92_RS14015	COG0667	Aldo Keto reductase
D4A92_RS14020	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D4A92_RS14040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D4A92_RS14065	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D4A92_RS14075	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
D4A92_RS14085	COG0741	lytic transglycosylase activity
D4A92_RS14090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A92_RS14105	COG2801	Transposase and inactivated derivatives
D4A92_RS14125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D4A92_RS14140	COG1758	RNA polymerase activity
D4A92_RS14160	COG0736	holo-[acyl-carrier-protein] synthase activity
D4A92_RS14165	COG0681	Belongs to the peptidase S26 family
D4A92_RS14170	COG0571	ribonuclease III activity
D4A92_RS14175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D4A92_RS14180	COG3180	Ammonia monooxygenase
D4A92_RS14190	COG1381	Involved in DNA repair and RecF pathway recombination
D4A92_RS14210	COG1418	mRNA catabolic process
D4A92_RS14220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D4A92_RS14225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D4A92_RS14240	COG0668	transmembrane transport
D4A92_RS14255	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D4A92_RS14260	COG0354	folic acid binding
D4A92_RS14295	COG1183	phosphatidylcholine synthase activity
D4A92_RS14300	COG0688	phosphatidylethanolamine metabolic process
D4A92_RS14305	COG3706	GGDEF domain
D4A92_RS14310	COG5265	(ABC) transporter
D4A92_RS14325	COG2962	Rard protein
D4A92_RS14330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D4A92_RS14350	COG2852	Protein conserved in bacteria
D4A92_RS14355	COG0215	cysteine-tRNA ligase activity
D4A92_RS14360	COG3706	GGDEF domain
D4A92_RS14365	COG0697	spore germination
D4A92_RS14370	COG4221	oxidoreductase activity
D4A92_RS14375	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D4A92_RS14380	COG1286	toxin biosynthetic process
D4A92_RS14400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D4A92_RS14420	COG0305	Participates in initiation and elongation during chromosome replication
D4A92_RS14425	COG0359	binds to the 23S rRNA
D4A92_RS14435	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D4A92_RS14440	COG0360	Binds together with S18 to 16S ribosomal RNA
D4A92_RS14455	COG0667	Aldo Keto reductase
D4A92_RS14460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D4A92_RS14470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D4A92_RS14475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D4A92_RS14480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D4A92_RS14485	COG1561	YicC-like family, N-terminal region
D4A92_RS14490	COG0194	GDP metabolic process
D4A92_RS14495	COG3119	arylsulfatase activity
D4A92_RS14510	COG0840	transmembrane signaling receptor activity
D4A92_RS14515	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D4A92_RS14520	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D4A92_RS14530	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
D4A92_RS14545	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D4A92_RS14555	COG1505	serine-type exopeptidase activity
D4A92_RS14560	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
D4A92_RS14570	COG0488	(ABC) transporter
D4A92_RS14600	COG0105	UTP biosynthetic process
D4A92_RS14605	COG0314	molybdopterin synthase activity
D4A92_RS14615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D4A92_RS14620	COG0322	excinuclease ABC activity
D4A92_RS14625	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS14645	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
D4A92_RS14650	COG0243	molybdopterin cofactor binding
D4A92_RS14655	COG0494	nUDIX hydrolase
D4A92_RS14665	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D4A92_RS14670	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D4A92_RS14675	COG0628	permease
D4A92_RS14685	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D4A92_RS14690	COG0248	Ppx GppA phosphatase
D4A92_RS14720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
D4A92_RS14735	COG2816	NAD+ diphosphatase activity
D4A92_RS14760	COG1309	transcriptional regulator
D4A92_RS14770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D4A92_RS14780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4A92_RS14790	COG5001	Diguanylate cyclase
D4A92_RS14790	COG3300	MHYT domain
D4A92_RS14800	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D4A92_RS14810	COG0113	porphobilinogen synthase activity
D4A92_RS14835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D4A92_RS14840	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D4A92_RS14845	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A92_RS14845	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D4A92_RS14855	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D4A92_RS14860	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D4A92_RS14865	COG2814	Major facilitator Superfamily
D4A92_RS14870	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D4A92_RS14890	COG0416	fatty acid biosynthetic process
D4A92_RS14895	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D4A92_RS14900	COG0776	regulation of translation
D4A92_RS14945	COG0297	glycogen (starch) synthase activity
D4A92_RS14970	COG1612	heme a metabolic process
D4A92_RS14975	COG3384	dioxygenase
D4A92_RS14980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D4A92_RS14985	COG0010	Belongs to the arginase family
D4A92_RS14990	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D4A92_RS14995	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D4A92_RS15015	COG1832	CoA-binding protein
D4A92_RS15050	COG2124	cytochrome p450
D4A92_RS15055	COG2199	diguanylate cyclase activity
D4A92_RS15060	COG0740	serine-type endopeptidase activity
D4A92_RS15065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D4A92_RS15070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D4A92_RS15080	COG0697	spore germination
D4A92_RS15090	COG0667	Aldo Keto reductase
D4A92_RS15105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D4A92_RS15110	COG2186	Transcriptional regulator
D4A92_RS15115	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D4A92_RS15145	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A92_RS15150	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A92_RS15155	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A92_RS15160	COG0649	NAD binding
D4A92_RS15170	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D4A92_RS15175	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D4A92_RS15180	COG3743	rRNA binding
D4A92_RS15180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D4A92_RS15190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D4A92_RS15195	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D4A92_RS15220	COG1007	ATP synthesis coupled electron transport
D4A92_RS15235	COG0346	lactoylglutathione lyase activity
D4A92_RS15245	COG0442	prolyl-tRNA aminoacylation
D4A92_RS15255	COG1136	(ABC) transporter
D4A92_RS15275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D4A92_RS15290	COG0784	Response regulator, receiver
D4A92_RS15300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D4A92_RS15305	COG0477	Major facilitator Superfamily
D4A92_RS15320	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D4A92_RS15320	COG1754	DNA topoisomerase type I activity
D4A92_RS15330	COG0758	DNA mediated transformation
D4A92_RS15335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D4A92_RS15340	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D4A92_RS15345	COG0540	Belongs to the ATCase OTCase family
D4A92_RS15350	COG1960	acyl-CoA dehydrogenase activity
D4A92_RS15370	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D4A92_RS15375	COG2824	Alkylphosphonate utilization operon protein PhnA
D4A92_RS15380	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D4A92_RS15385	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D4A92_RS15390	COG0154	amidase activity
D4A92_RS15410	COG3811	Belongs to the UPF0386 family
D4A92_RS15415	COG0454	-acetyltransferase
D4A92_RS15425	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D4A92_RS15470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D4A92_RS15475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D4A92_RS15475	COG2010	Cytochrome c
D4A92_RS15495	COG0243	molybdopterin cofactor binding
D4A92_RS15500	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A92_RS15520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D4A92_RS15530	COG0511	ligase activity, forming carbon-carbon bonds
D4A92_RS15535	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D4A92_RS15545	COG0436	Aminotransferase
D4A92_RS15555	COG1530	ribonuclease E activity
D4A92_RS15560	COG1388	LysM domain
D4A92_RS15560	COG0860	N-Acetylmuramoyl-L-alanine amidase
D4A92_RS15585	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D4A92_RS15600	COG1215	transferase activity, transferring glycosyl groups
D4A92_RS15605	COG3769	mannosylglycerate metabolic process
D4A92_RS15610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D4A92_RS15625	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D4A92_RS15650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4A92_RS15660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D4A92_RS15665	COG0081	regulation of translation
D4A92_RS15670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D4A92_RS15675	COG0222	ribosome binding
D4A92_RS15680	COG0085	RNA polymerase activity
D4A92_RS15685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D4A92_RS15695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D4A92_RS15700	COG0049	tRNA binding
D4A92_RS15705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D4A92_RS15710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D4A92_RS15715	COG0051	transcription antitermination factor activity, RNA binding
D4A92_RS15720	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D4A92_RS15725	COG0088	Forms part of the polypeptide exit tunnel
D4A92_RS15730	COG0089	rRNA binding
D4A92_RS15735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D4A92_RS15740	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D4A92_RS15745	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D4A92_RS15750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D4A92_RS15755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D4A92_RS15760	COG0255	Belongs to the universal ribosomal protein uL29 family
D4A92_RS15765	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D4A92_RS15770	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D4A92_RS15775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D4A92_RS15780	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D4A92_RS15785	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D4A92_RS15790	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D4A92_RS15795	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D4A92_RS15800	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D4A92_RS15805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D4A92_RS15810	COG1841	ribosomal large subunit assembly
D4A92_RS15815	COG0200	Binds to the 23S rRNA
D4A92_RS15825	COG0563	adenylate kinase activity
D4A92_RS15830	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D4A92_RS15835	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D4A92_RS15840	COG0202	RNA polymerase activity
D4A92_RS15845	COG0203	ribosomal protein L17
D4A92_RS15855	COG4941	Belongs to the sigma-70 factor family
D4A92_RS15865	COG3795	YCII-related domain
D4A92_RS15870	COG3739	integral membrane protein
D4A92_RS15880	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D4A92_RS15885	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D4A92_RS15895	COG0129	dihydroxy-acid dehydratase activity
D4A92_RS15905	COG0235	Class ii aldolase
D4A92_RS15925	COG1017	nitric oxide dioxygenase activity
D4A92_RS15925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D4A92_RS15945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D4A92_RS15970	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D4A92_RS15980	COG0840	transmembrane signaling receptor activity
D4A92_RS15985	COG0702	epimerase
D4A92_RS16015	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D4A92_RS16025	COG1058	Belongs to the CinA family
D4A92_RS16025	COG1546	Belongs to the CinA family
D4A92_RS16030	COG0655	NAD(P)H dehydrogenase (quinone) activity
D4A92_RS16045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A92_RS16055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS16065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D4A92_RS16070	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D4A92_RS16085	COG3300	MHYT domain
D4A92_RS16085	COG5001	Diguanylate cyclase
D4A92_RS16090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D4A92_RS16095	COG0583	DNA-binding transcription factor activity
D4A92_RS16100	COG0737	Belongs to the 5'-nucleotidase family
D4A92_RS16115	COG1522	sequence-specific DNA binding
D4A92_RS16120	COG0686	Belongs to the AlaDH PNT family
D4A92_RS16140	COG2897	thiosulfate sulfurtransferase activity
D4A92_RS16150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D4A92_RS16170	COG0415	Belongs to the DNA photolyase family
D4A92_RS16200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D4A92_RS16210	COG0525	valine-tRNA ligase activity
D4A92_RS16235	COG0316	Belongs to the HesB IscA family
D4A92_RS16240	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D4A92_RS16245	COG0018	arginyl-trna synthetase
D4A92_RS16255	COG1472	Belongs to the glycosyl hydrolase 3 family
D4A92_RS16265	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D4A92_RS16275	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D4A92_RS16280	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D4A92_RS16285	COG0805	protein transport
D4A92_RS16290	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D4A92_RS16295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D4A92_RS16300	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D4A92_RS16315	COG1862	Preprotein translocase
D4A92_RS16340	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D4A92_RS16350	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D4A92_RS16355	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D4A92_RS16375	COG2945	thiolester hydrolase activity
D4A92_RS16385	COG0719	Fe-S assembly protein
D4A92_RS16390	COG0396	ATPase activity
D4A92_RS16395	COG0719	Fe-S assembly protein
D4A92_RS16400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D4A92_RS16405	COG2151	metal-sulfur cluster biosynthetic enzyme
D4A92_RS16410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D4A92_RS16415	COG2267	carboxylic ester hydrolase activity
D4A92_RS16420	COG0251	oxidation-reduction process
D4A92_RS16425	COG1335	isochorismatase
D4A92_RS16430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D4A92_RS16435	COG0316	Belongs to the HesB IscA family
D4A92_RS16475	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D4A92_RS16475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D4A92_RS16480	COG0509	glycine decarboxylation via glycine cleavage system
D4A92_RS16485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D4A92_RS16510	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D4A92_RS16515	COG0564	pseudouridine synthase activity
D4A92_RS16520	COG0546	phosphoglycolate phosphatase activity
D4A92_RS16565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D4A92_RS16595	COG2875	Belongs to the precorrin methyltransferase family
D4A92_RS16630	COG0544	peptidyl-prolyl cis-trans isomerase activity
D4A92_RS16635	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D4A92_RS16650	COG2003	Belongs to the UPF0758 family
D4A92_RS16655	COG0024	Methionine aminopeptidase
D4A92_RS16660	COG1489	DNA binding
D4A92_RS16665	COG1733	regulation of RNA biosynthetic process
D4A92_RS16675	COG3243	poly(R)-hydroxyalkanoic acid synthase
D4A92_RS16685	COG0436	Aminotransferase
D4A92_RS16700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D4A92_RS16700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D4A92_RS16730	COG1278	Cold shock
D4A92_RS16760	COG1126	abc transporter atp-binding protein
D4A92_RS16765	COG0765	amino acid transport
D4A92_RS16770	COG4597	amino acid ABC transporter
D4A92_RS16775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A92_RS16780	COG0626	cystathionine gamma-synthase activity
D4A92_RS16800	COG1024	Enoyl-CoA hydratase
D4A92_RS16820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D4A92_RS16845	COG0537	adenosine 5'-monophosphoramidase activity
D4A92_RS16870	COG0052	Belongs to the universal ribosomal protein uS2 family
D4A92_RS16875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D4A92_RS16880	COG0528	UMP kinase activity
D4A92_RS16885	COG0233	cytoplasmic translational termination
D4A92_RS16890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D4A92_RS16900	COG0750	zinc metalloprotease
D4A92_RS16905	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4A92_RS16910	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4A92_RS16915	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D4A92_RS16920	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4A92_RS16925	COG3494	Protein of unknown function (DUF1009)
D4A92_RS16930	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D4A92_RS16935	COG0523	cobalamin synthesis protein
D4A92_RS16945	COG1121	(ABC) transporter
D4A92_RS16950	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D4A92_RS16970	COG1686	Belongs to the peptidase S11 family
D4A92_RS17000	COG1752	Esterase of the alpha-beta hydrolase superfamily
D4A92_RS17005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D4A92_RS17010	COG0302	gtp cyclohydrolase
D4A92_RS17020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D4A92_RS17030	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D4A92_RS17065	COG0628	permease
D4A92_RS17070	COG0187	DNA topoisomerase II activity
D4A92_RS17080	COG0149	triose-phosphate isomerase activity
D4A92_RS17085	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D4A92_RS17090	COG0504	CTP synthase activity
D4A92_RS17100	COG0303	'Molybdopterin
D4A92_RS17105	COG0315	cyclic pyranopterin monophosphate synthase activity
D4A92_RS17110	COG0134	indole-3-glycerol-phosphate synthase activity
D4A92_RS17115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D4A92_RS17125	COG0372	Belongs to the citrate synthase family
D4A92_RS17135	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D4A92_RS17150	COG2877	3-deoxy-8-phosphooctulonate synthase activity
D4A92_RS17155	COG0148	phosphopyruvate hydratase activity
D4A92_RS17165	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D4A92_RS17170	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A92_RS17170	COG0022	dehydrogenase e1 component
D4A92_RS17175	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A92_RS17190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D4A92_RS17200	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D4A92_RS17220	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D4A92_RS17220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D4A92_RS17230	COG3852	Histidine kinase
D4A92_RS17235	COG2204	response regulator
D4A92_RS17240	COG5000	phosphorelay sensor kinase activity
D4A92_RS17245	COG2204	response regulator
D4A92_RS17250	COG0569	domain protein
D4A92_RS17260	COG1923	regulation of RNA biosynthetic process
D4A92_RS17265	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D4A92_RS17270	COG1032	radical SAM domain protein
D4A92_RS17275	COG1719	4-vinyl reductase, 4VR
D4A92_RS17280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D4A92_RS17285	COG3956	TIGRFAM MazG family protein
D4A92_RS17295	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D4A92_RS17295	COG1648	precorrin-2 dehydrogenase activity
D4A92_RS17320	COG1410	methionine synthase
D4A92_RS17320	COG0646	methionine synthase
D4A92_RS17325	COG0517	IMP dehydrogenase activity
D4A92_RS17325	COG4175	Glycine betaine
D4A92_RS17330	COG4176	ABC-type proline glycine betaine transport system permease component
D4A92_RS17355	COG1686	Belongs to the peptidase S11 family
D4A92_RS17360	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D4A92_RS17370	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4A92_RS17375	COG0084	hydrolase, TatD family'
D4A92_RS17380	COG1234	tRNA 3'-trailer cleavage
D4A92_RS17385	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D4A92_RS17400	COG0343	queuine tRNA-ribosyltransferase activity
D4A92_RS17405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D4A92_RS17420	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D4A92_RS17435	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D4A92_RS17440	COG2095	MarC family integral membrane protein
D4A92_RS17445	COG0629	single-stranded DNA binding
D4A92_RS17450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D4A92_RS17475	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D4A92_RS17475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D4A92_RS17480	COG0347	Belongs to the P(II) protein family
D4A92_RS17485	COG0174	glutamine synthetase
D4A92_RS17515	COG0697	spore germination
D4A92_RS17520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D4A92_RS17530	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D4A92_RS17540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D4A92_RS17545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D4A92_RS17550	COG2186	Transcriptional regulator
D4A92_RS17560	COG1079	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS17565	COG4603	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS17570	COG3845	ABC transporter
D4A92_RS17575	COG1183	phosphatidylcholine synthase activity
D4A92_RS17580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D4A92_RS17585	COG0679	Auxin Efflux Carrier
D4A92_RS17590	COG0785	Cytochrome C biogenesis protein
D4A92_RS17605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D4A92_RS17610	COG1136	(ABC) transporter
D4A92_RS17610	COG0577	efflux transmembrane transporter activity
D4A92_RS17615	COG0577	efflux transmembrane transporter activity
D4A92_RS17615	COG1136	(ABC) transporter
D4A92_RS17625	COG3698	Phosphodiester glycosidase
D4A92_RS17635	COG5598	trimethylamine methyltransferase
D4A92_RS17640	COG5012	cobalamin binding
D4A92_RS17685	COG0646	methionine synthase
D4A92_RS17685	COG1410	methionine synthase
D4A92_RS17710	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D4A92_RS17715	COG1309	transcriptional regulator
D4A92_RS17730	COG0406	alpha-ribazole phosphatase activity
D4A92_RS17740	COG0583	DNA-binding transcription factor activity
D4A92_RS17765	COG0730	response to heat
D4A92_RS17775	COG0840	transmembrane signaling receptor activity
D4A92_RS17805	COG0556	nucleotide-excision repair
D4A92_RS17840	COG0484	heat shock protein binding
D4A92_RS17850	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D4A92_RS17860	COG1760	l-serine dehydratase
D4A92_RS17885	COG2239	Acts as a magnesium transporter
D4A92_RS17890	COG0242	peptide deformylase activity
D4A92_RS17905	COG0321	lipoyl(octanoyl) transferase activity
D4A92_RS17930	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D4A92_RS17945	COG1671	Belongs to the UPF0178 family
D4A92_RS17950	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
D4A92_RS17960	COG0667	Aldo Keto reductase
D4A92_RS17985	COG0395	ABC-type sugar transport system, permease component
D4A92_RS17990	COG1175	transmembrane transport
D4A92_RS18015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D4A92_RS18080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D4A92_RS18090	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D4A92_RS18095	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D4A92_RS18100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D4A92_RS18145	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D4A92_RS18150	COG2833	Protein of unknown function (DUF455)
D4A92_RS18155	COG0739	heme binding
D4A92_RS18160	COG0513	Belongs to the DEAD box helicase family
D4A92_RS18175	COG2068	MobA-Related Protein
D4A92_RS18180	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D4A92_RS18180	COG3608	succinylglutamate desuccinylase aspartoacylase
D4A92_RS18195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D4A92_RS18200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D4A92_RS18210	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS18230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D4A92_RS18255	COG5001	Diguanylate cyclase
D4A92_RS18265	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D4A92_RS18270	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D4A92_RS18280	COG0047	phosphoribosylformylglycinamidine synthase activity
D4A92_RS18295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A92_RS18300	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D4A92_RS18325	COG2814	Major facilitator Superfamily
D4A92_RS18330	COG0483	inositol monophosphate 1-phosphatase activity
D4A92_RS18350	COG0037	tRNA processing
D4A92_RS18355	COG2066	Belongs to the glutaminase family
D4A92_RS18360	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D4A92_RS18365	COG1686	Belongs to the peptidase S11 family
D4A92_RS18370	COG2195	Cleaves the N-terminal amino acid of tripeptides
D4A92_RS18390	COG1253	flavin adenine dinucleotide binding
D4A92_RS18395	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D4A92_RS18400	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D4A92_RS18415	COG0538	isocitrate dehydrogenase activity
D4A92_RS18425	COG0659	secondary active sulfate transmembrane transporter activity
D4A92_RS18435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D4A92_RS18440	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D4A92_RS18450	COG2313	pseudouridylate synthase activity
D4A92_RS18475	COG3106	COG3106 Predicted ATPase
D4A92_RS18480	COG3768	UPF0283 membrane protein
D4A92_RS18490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D4A92_RS18500	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D4A92_RS18510	COG0633	Ferredoxin
D4A92_RS18535	COG1127	ABC transporter
D4A92_RS18540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D4A92_RS18550	COG0281	malic enzyme
D4A92_RS18550	COG0280	phosphate acetyltransferase
D4A92_RS18570	COG0778	Nitroreductase
D4A92_RS18575	COG0823	Involved in the tonB-independent uptake of proteins
D4A92_RS18590	COG1368	sulfuric ester hydrolase activity
D4A92_RS18605	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D4A92_RS18625	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D4A92_RS18630	COG0546	phosphoglycolate phosphatase activity
D4A92_RS18640	COG0114	fumarate hydratase activity
D4A92_RS18650	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D4A92_RS18650	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D4A92_RS18655	COG3706	GGDEF domain
D4A92_RS18670	COG1846	Transcriptional regulator
D4A92_RS18680	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D4A92_RS18685	COG0840	transmembrane signaling receptor activity
D4A92_RS18700	COG0746	molybdenum cofactor guanylyltransferase activity
D4A92_RS18705	COG1763	Mo-molybdopterin cofactor biosynthetic process
D4A92_RS18710	COG2885	chlorophyll binding
D4A92_RS18730	COG5425	PFAM Usg family protein
D4A92_RS18750	COG2084	Dehydrogenase
D4A92_RS18760	COG1522	sequence-specific DNA binding
D4A92_RS18765	COG1573	uracil-dna glycosylase
D4A92_RS18775	COG2202	Pas domain
D4A92_RS18775	COG2205	protein histidine kinase activity
D4A92_RS18785	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D4A92_RS18790	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D4A92_RS18805	COG0842	Transport permease protein
D4A92_RS18810	COG1131	(ABC) transporter
D4A92_RS18820	COG0745	RESPONSE REGULATOR receiver
D4A92_RS18830	COG3264	Mechanosensitive ion channel
D4A92_RS18830	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D4A92_RS18845	COG4558	Periplasmic binding protein
D4A92_RS18850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D4A92_RS18855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
D4A92_RS18865	COG0384	phenazine biosynthesis protein PhzF
D4A92_RS18880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D4A92_RS18885	COG2203	Gaf domain
D4A92_RS18885	COG3706	GGDEF domain
D4A92_RS18885	COG5001	Diguanylate cyclase
D4A92_RS18885	COG4251	negative regulation of phosphorylation
D4A92_RS18890	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D4A92_RS18930	COG1522	sequence-specific DNA binding
D4A92_RS18935	COG1794	racemase activity, acting on amino acids and derivatives
D4A92_RS18940	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D4A92_RS18960	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D4A92_RS18985	COG0656	L-ascorbic acid biosynthetic process
D4A92_RS18990	COG0640	Transcriptional regulator
D4A92_RS18995	COG0440	acetolactate synthase activity
D4A92_RS19000	COG0028	Belongs to the TPP enzyme family
D4A92_RS19010	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D4A92_RS19015	COG0560	Phosphoserine phosphatase
D4A92_RS19015	COG3830	Belongs to the UPF0237 family
D4A92_RS19025	COG3300	MHYT domain
D4A92_RS19025	COG5001	Diguanylate cyclase
D4A92_RS19040	COG0330	HflC and HflK could
D4A92_RS19045	COG0330	HflC and HflK could
D4A92_RS19055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
D4A92_RS19085	COG0277	FAD linked oxidase domain protein
D4A92_RS19090	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D4A92_RS19110	COG1435	thymidine kinase activity
D4A92_RS19120	COG4993	Dehydrogenase
D4A92_RS19125	COG1335	isochorismatase
D4A92_RS19130	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D4A92_RS19135	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D4A92_RS19165	COG2264	protein methyltransferase activity
D4A92_RS19170	COG1999	signal sequence binding
D4A92_RS19185	COG2972	Histidine kinase
D4A92_RS19185	COG0840	transmembrane signaling receptor activity
D4A92_RS19190	COG0835	chemotaxis
D4A92_RS19230	COG2199	diguanylate cyclase activity
D4A92_RS19235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D4A92_RS19245	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D4A92_RS19255	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D4A92_RS19265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D4A92_RS19270	COG0849	cell division
D4A92_RS19275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D4A92_RS19280	COG1181	Belongs to the D-alanine--D-alanine ligase family
D4A92_RS19285	COG3706	GGDEF domain
D4A92_RS19290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D4A92_RS19295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D4A92_RS19300	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D4A92_RS19310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D4A92_RS19315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D4A92_RS19325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D4A92_RS19340	COG0275	rRNA processing
D4A92_RS19345	COG2001	Belongs to the MraZ family
D4A92_RS19365	COG3023	N-Acetylmuramoyl-L-alanine amidase
D4A92_RS19370	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D4A92_RS19395	COG5001	Diguanylate cyclase
D4A92_RS19395	COG3300	MHYT domain
D4A92_RS19430	COG0840	transmembrane signaling receptor activity
D4A92_RS19445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D4A92_RS19450	COG0028	Belongs to the TPP enzyme family
D4A92_RS19485	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS19505	COG0174	glutamine synthetase
D4A92_RS19510	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
D4A92_RS19550	COG3842	ATPase activity
D4A92_RS19575	COG2942	2-epimerase
D4A92_RS19580	COG2968	Membrane
D4A92_RS19600	COG4397	Mu-like prophage major head subunit gpT
D4A92_RS19755	COG4397	Mu-like prophage major head subunit gpT
D4A92_RS19775	COG4383	Mu-like prophage protein gp29
D4A92_RS19830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
D4A92_RS19890	COG2801	Transposase and inactivated derivatives
D4A92_RS19970	COG0432	Pfam Uncharacterised protein family UPF0047
D4A92_RS19975	COG4702	Belongs to the UPF0303 family
D4A92_RS19995	COG1473	amidohydrolase
D4A92_RS20015	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D4A92_RS20025	COG0358	DNA primase activity
D4A92_RS20045	COG0505	Belongs to the CarA family
D4A92_RS20050	COG0534	Mate efflux family protein
D4A92_RS20060	COG2321	neutral zinc metallopeptidase
D4A92_RS20070	COG1063	alcohol dehydrogenase
D4A92_RS20080	COG0840	transmembrane signaling receptor activity
D4A92_RS20090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D4A92_RS20115	COG0477	Major facilitator Superfamily
D4A92_RS20130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D4A92_RS20145	COG1522	sequence-specific DNA binding
D4A92_RS20150	COG0492	ferredoxin-NADP+ reductase activity
D4A92_RS20155	COG0583	DNA-binding transcription factor activity
D4A92_RS20165	COG1902	pentaerythritol trinitrate reductase activity
D4A92_RS20185	COG2133	pyrroloquinoline quinone binding
D4A92_RS20200	COG0436	Aminotransferase
D4A92_RS20210	COG2133	pyrroloquinoline quinone binding
D4A92_RS20215	COG1278	Cold shock
D4A92_RS20225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D4A92_RS20235	COG1846	Transcriptional regulator
D4A92_RS20240	COG0745	RESPONSE REGULATOR receiver
D4A92_RS20245	COG2205	protein histidine kinase activity
D4A92_RS20250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D4A92_RS20270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D4A92_RS20280	COG1496	oxidoreductase activity
D4A92_RS20285	COG0006	proline dipeptidase activity
D4A92_RS20295	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D4A92_RS20310	COG1012	belongs to the aldehyde dehydrogenase family
D4A92_RS20320	COG3300	MHYT domain
D4A92_RS20320	COG5001	Diguanylate cyclase
D4A92_RS20330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D4A92_RS20345	COG0193	aminoacyl-tRNA hydrolase activity
D4A92_RS20350	COG2890	protein-(glutamine-N5) methyltransferase activity
D4A92_RS20360	COG0251	oxidation-reduction process
D4A92_RS20370	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D4A92_RS20375	COG0012	GTP binding
D4A92_RS20400	COG0386	Belongs to the glutathione peroxidase family
D4A92_RS20410	COG1280	lysine exporter protein (LysE YggA)
D4A92_RS20415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D4A92_RS20420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D4A92_RS20420	COG2857	Cytochrome c1
D4A92_RS20435	COG1132	(ABC) transporter
D4A92_RS20465	COG1132	(ABC) transporter
D4A92_RS20470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D4A92_RS20490	COG0408	coproporphyrinogen oxidase activity
D4A92_RS20505	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D4A92_RS20510	COG0617	tRNA 3'-terminal CCA addition
D4A92_RS20525	COG0714	Associated with various cellular activities
D4A92_RS20545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D4A92_RS20560	COG0454	-acetyltransferase
D4A92_RS20570	COG0435	Glutathione S-transferase
D4A92_RS20585	COG0596	Alpha beta hydrolase
D4A92_RS20585	COG0508	dehydrogenase complex catalyzes the overall conversion of
D4A92_RS20590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D4A92_RS20610	COG3135	benzoate transporter
D4A92_RS20615	COG0019	diaminopimelate decarboxylase activity
D4A92_RS20635	COG0740	serine-type endopeptidase activity
D4A92_RS20640	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D4A92_RS20645	COG1522	sequence-specific DNA binding
D4A92_RS20690	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D4A92_RS20740	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D4A92_RS20745	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D4A92_RS20750	COG4774	siderophore transport
D4A92_RS20775	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D4A92_RS20775	COG0512	Glutamine amidotransferase of anthranilate synthase
D4A92_RS20785	COG4771	TonB-dependent receptor
D4A92_RS20785	COG1629	transport
D4A92_RS20790	COG2759	Belongs to the formate--tetrahydrofolate ligase family
D4A92_RS20795	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS20800	COG2207	Transcriptional regulator
D4A92_RS20805	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D4A92_RS20805	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
D4A92_RS20805	COG0506	proline dehydrogenase activity
D4A92_RS20815	COG2197	response regulator
D4A92_RS20870	COG4175	Glycine betaine
D4A92_RS20885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D4A92_RS20900	COG0628	permease
D4A92_RS20910	COG3011	Protein conserved in bacteria
D4A92_RS20930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D4A92_RS20945	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D4A92_RS20960	COG4115	mRNA cleavage
D4A92_RS20975	COG0366	Alpha amylase catalytic
D4A92_RS20980	COG0297	glycogen (starch) synthase activity
D4A92_RS20980	COG0438	transferase activity, transferring glycosyl groups
D4A92_RS20985	COG1160	GTP binding
D4A92_RS21010	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D4A92_RS21020	COG0024	Methionine aminopeptidase
D4A92_RS21030	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS21040	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D4A92_RS21065	COG0583	DNA-binding transcription factor activity
D4A92_RS21075	COG0402	S-adenosylhomocysteine deaminase activity
D4A92_RS21095	COG2351	hydroxyisourate hydrolase activity
D4A92_RS21100	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
D4A92_RS21115	COG0174	glutamine synthetase
D4A92_RS21125	COG4266	Belongs to the allantoicase family
D4A92_RS21130	COG3648	Uricase
D4A92_RS21130	COG3195	allantoin biosynthetic process
D4A92_RS21135	COG1064	alcohol dehydrogenase
D4A92_RS21155	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
D4A92_RS21160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS21160	COG2022	thiamine diphosphate biosynthetic process
D4A92_RS21165	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D4A92_RS21165	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D4A92_RS21170	COG0784	Response regulator, receiver
D4A92_RS21170	COG2205	protein histidine kinase activity
D4A92_RS21170	COG5002	protein histidine kinase activity
D4A92_RS21175	COG5598	trimethylamine methyltransferase
D4A92_RS21190	COG4335	DNA alkylation repair
D4A92_RS21200	COG0513	Belongs to the DEAD box helicase family
D4A92_RS21215	COG2308	Evidence 4 Homologs of previously reported genes of
D4A92_RS21245	COG0318	PFAM AMP-dependent synthetase and ligase
D4A92_RS21250	COG0385	Bile acid
D4A92_RS21285	COG0488	(ABC) transporter
D4A92_RS21290	COG2346	COG2346, Truncated hemoglobins
D4A92_RS21310	COG0493	'glutamate synthase
D4A92_RS21325	COG3932	Exopolysaccharide synthesis, ExoD
D4A92_RS21335	COG1309	transcriptional regulator
D4A92_RS21380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS21385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D4A92_RS21390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D4A92_RS21405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D4A92_RS21410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D4A92_RS21415	COG0830	nickel cation binding
D4A92_RS21420	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D4A92_RS21425	COG3706	GGDEF domain
D4A92_RS21435	COG0804	urea catabolic process
D4A92_RS21440	COG1442	glycosyl transferase family 8
D4A92_RS21445	COG3755	Protein conserved in bacteria
D4A92_RS21450	COG0832	Belongs to the urease beta subunit family
D4A92_RS21455	COG0831	urea catabolic process
D4A92_RS21460	COG0829	nickel cation binding
D4A92_RS21485	COG2801	Transposase and inactivated derivatives
D4A92_RS21490	COG2842	Transposition protein
D4A92_RS21555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A92_RS21555	COG2205	protein histidine kinase activity
D4A92_RS21565	COG0683	leucine binding
D4A92_RS21615	COG4172	Belongs to the ABC transporter superfamily
D4A92_RS21625	COG0747	negative chemotaxis
D4A92_RS21635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS21650	COG3550	peptidyl-serine autophosphorylation
D4A92_RS21655	COG3620	sequence-specific DNA binding
D4A92_RS21705	COG1802	Transcriptional regulator
D4A92_RS21715	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D4A92_RS21715	COG1082	Xylose isomerase domain protein TIM barrel
D4A92_RS21720	COG1473	amidohydrolase
D4A92_RS21740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS21745	COG0601	transmembrane transport
D4A92_RS21760	COG1487	ribonuclease activity
D4A92_RS21765	COG4691	Plasmid stability protein
D4A92_RS21785	COG1959	2 iron, 2 sulfur cluster binding
D4A92_RS21790	COG4221	oxidoreductase activity
D4A92_RS21800	COG4221	oxidoreductase activity
D4A92_RS21810	COG0300	oxidoreductase activity
D4A92_RS21830	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS21835	COG1309	transcriptional regulator
D4A92_RS21985	COG3384	dioxygenase
D4A92_RS22000	COG3246	L-lysine catabolic process to acetate
D4A92_RS22010	COG0402	S-adenosylhomocysteine deaminase activity
D4A92_RS22030	COG0657	acetylesterase activity
D4A92_RS22035	COG0583	DNA-binding transcription factor activity
D4A92_RS22065	COG2828	Protein conserved in bacteria
D4A92_RS22080	COG4774	siderophore transport
D4A92_RS22085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D4A92_RS22100	COG1120	ATPase activity
D4A92_RS22105	COG3177	Filamentation induced by cAMP protein fic
D4A92_RS22140	COG0318	PFAM AMP-dependent synthetase and ligase
D4A92_RS22155	COG4608	Belongs to the ABC transporter superfamily
D4A92_RS22165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D4A92_RS22170	COG0601	transmembrane transport
D4A92_RS22175	COG0747	negative chemotaxis
D4A92_RS22180	COG1802	Transcriptional regulator
D4A92_RS22220	COG0402	S-adenosylhomocysteine deaminase activity
D4A92_RS22225	COG1079	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS22235	COG3845	ABC transporter
D4A92_RS22250	COG2390	Transcriptional regulator
D4A92_RS22255	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS22255	COG3347	Dehydrogenase
D4A92_RS22265	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS22270	COG1129	ABC transporter
D4A92_RS22280	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D4A92_RS22285	COG3959	Transketolase, thiamine diphosphate binding domain
D4A92_RS22290	COG3958	Transketolase
D4A92_RS22295	COG1850	ribulose-bisphosphate carboxylase activity
D4A92_RS22330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D4A92_RS22385	COG0640	Transcriptional regulator
D4A92_RS22390	COG1475	DNA binding
D4A92_RS22395	COG1192	Involved in chromosome partitioning
D4A92_RS22405	COG4962	Type ii secretion system protein e
D4A92_RS22410	COG3838	Conjugal transfer protein Trbc
D4A92_RS22415	COG5268	conjugation
D4A92_RS22420	COG3451	type IV secretory pathway VirB4
D4A92_RS22425	COG5314	conjugation
D4A92_RS22430	COG3846	protein secretion by the type IV secretion system
D4A92_RS22435	COG3701	Conjugal transfer protein
D4A92_RS22440	COG3504	Conjugal transfer protein
D4A92_RS22450	COG2948	multi-organism process
D4A92_RS22465	COG0745	RESPONSE REGULATOR receiver
D4A92_RS22500	COG1653	transport
D4A92_RS22505	COG1175	transmembrane transport
D4A92_RS22510	COG0395	ABC-type sugar transport system, permease component
D4A92_RS22515	COG1063	alcohol dehydrogenase
D4A92_RS22520	COG3842	ATPase activity
D4A92_RS22555	COG3842	ATPase activity
D4A92_RS22560	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D4A92_RS22565	COG1176	ABC-type spermidine putrescine transport system, permease component I
D4A92_RS22580	COG0583	DNA-binding transcription factor activity
D4A92_RS22590	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS22595	COG4644	lycopene metabolic process
D4A92_RS22635	COG0662	Cupin 2, conserved barrel domain protein
D4A92_RS22635	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
D4A92_RS22640	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D4A92_RS22655	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D4A92_RS22710	COG4372	Transposase
D4A92_RS22720	COG2963	transposase activity
D4A92_RS22725	COG2801	Transposase and inactivated derivatives
D4A92_RS22740	COG0489	protein tyrosine kinase activity
D4A92_RS22790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D4A92_RS22795	COG1968	undecaprenyl-diphosphatase activity
D4A92_RS22815	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D4A92_RS22820	COG4959	Type IV secretory pathway protease TraF
D4A92_RS22825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D4A92_RS22840	COG3505	Type IV secretory pathway VirD4
D4A92_RS22845	COG3831	ATPase activity
D4A92_RS22850	COG1215	transferase activity, transferring glycosyl groups
D4A92_RS22870	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D4A92_RS22875	COG5489	Protein of unknown function (DUF736)
D4A92_RS22910	COG2801	Transposase and inactivated derivatives
D4A92_RS22920	COG1396	sequence-specific DNA binding
D4A92_RS22950	COG2963	transposase activity
D4A92_RS22970	COG3550	peptidyl-serine autophosphorylation
D4A92_RS22975	COG4227	nucleotidyltransferase activity
D4A92_RS22980	COG0420	3'-5' exonuclease activity
D4A92_RS22985	COG4717	serine-type aminopeptidase activity
D4A92_RS22995	COG2113	Glycine betaine
D4A92_RS23000	COG4175	Glycine betaine
D4A92_RS23000	COG3448	diguanylate cyclase activity
D4A92_RS23005	COG4176	ABC-type proline glycine betaine transport system permease component
D4A92_RS23035	COG0583	DNA-binding transcription factor activity
D4A92_RS23045	COG1609	Transcriptional regulator
D4A92_RS23055	COG1175	transmembrane transport
D4A92_RS23060	COG0395	ABC-type sugar transport system, permease component
D4A92_RS23070	COG3842	ATPase activity
D4A92_RS23075	COG3842	ATPase activity
D4A92_RS23100	COG2376	Dihydroxyacetone kinase
D4A92_RS23105	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS23110	COG1129	ABC transporter
D4A92_RS23135	COG0667	Aldo Keto reductase
D4A92_RS23140	COG4670	ketone body catabolic process
D4A92_RS23165	COG0235	Class ii aldolase
D4A92_RS23170	COG3395	kinase activity
D4A92_RS23175	COG1609	Transcriptional regulator
D4A92_RS23185	COG1129	ABC transporter
D4A92_RS23190	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS23195	COG1172	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS23200	COG2084	Dehydrogenase
D4A92_RS23205	COG3622	Belongs to the hyi family
D4A92_RS23220	COG1749	Flagellar hook protein flgE
D4A92_RS23240	COG3307	-O-antigen
D4A92_RS23250	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D4A92_RS23255	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D4A92_RS23280	COG2963	transposase activity
D4A92_RS23285	COG3436	PFAM IS66 Orf2 family protein
D4A92_RS23290	COG4372	Transposase
D4A92_RS23320	COG0438	transferase activity, transferring glycosyl groups
D4A92_RS23325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D4A92_RS23350	COG0583	DNA-binding transcription factor activity
D4A92_RS23360	COG0210	DNA helicase
D4A92_RS23385	COG3620	sequence-specific DNA binding
D4A92_RS23390	COG1278	Cold shock
D4A92_RS23400	COG2186	Transcriptional regulator
D4A92_RS23410	COG1653	transport
D4A92_RS23420	COG0395	ABC-type sugar transport system, permease component
D4A92_RS23425	COG3842	ATPase activity
D4A92_RS23455	COG2124	cytochrome p450
D4A92_RS23475	COG3685	Protein conserved in bacteria
D4A92_RS23480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D4A92_RS23485	COG4251	negative regulation of phosphorylation
D4A92_RS23485	COG3706	GGDEF domain
D4A92_RS23485	COG5001	Diguanylate cyclase
D4A92_RS23485	COG2203	Gaf domain
D4A92_RS23490	COG0840	transmembrane signaling receptor activity
D4A92_RS23510	COG3550	peptidyl-serine autophosphorylation
D4A92_RS23555	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D4A92_RS23560	COG3920	Histidine kinase
D4A92_RS23560	COG2202	Pas domain
D4A92_RS23580	COG0776	regulation of translation
D4A92_RS23595	COG4227	nucleotidyltransferase activity
D4A92_RS23605	COG3842	ATPase activity
D4A92_RS23610	COG1175	transmembrane transport
D4A92_RS23625	COG1609	Transcriptional regulator
D4A92_RS23660	COG0784	Response regulator, receiver
D4A92_RS23660	COG4191	Histidine kinase
D4A92_RS23665	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
D4A92_RS23670	COG0673	inositol 2-dehydrogenase activity
D4A92_RS23675	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D4A92_RS23695	COG1609	Transcriptional regulator
D4A92_RS23710	COG1129	ABC transporter
D4A92_RS23715	COG4211	Belongs to the binding-protein-dependent transport system permease family
D4A92_RS23725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D4A92_RS23750	COG1388	LysM domain
D4A92_RS23750	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS23755	COG0642	Histidine kinase
D4A92_RS23770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D4A92_RS23775	COG1388	LysM domain
D4A92_RS23775	COG1376	ErfK ybiS ycfS ynhG family protein
D4A92_RS23780	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D4A92_RS23780	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D4A92_RS23790	COG0165	Argininosuccinate lyase
D4A92_RS23795	COG0765	amino acid transport
D4A92_RS23800	COG1126	abc transporter atp-binding protein
D4A92_RS23805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D4A92_RS23810	COG0583	DNA-binding transcription factor activity
D4A92_RS23820	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS23830	COG0662	Cupin 2, conserved barrel domain protein
D4A92_RS23865	COG2194	sulfuric ester hydrolase activity
D4A92_RS23870	COG0583	DNA-binding transcription factor activity
D4A92_RS23875	COG0657	acetylesterase activity
D4A92_RS23890	COG3436	PFAM IS66 Orf2 family protein
D4A92_RS23905	COG0640	Transcriptional regulator
D4A92_RS23910	COG1475	DNA binding
D4A92_RS23915	COG1192	Involved in chromosome partitioning
D4A92_RS23970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D4A92_RS24025	COG0697	spore germination
D4A92_RS24050	COG1288	antiporter activity
D4A92_RS24055	COG2235	arginine
D4A92_RS24065	COG0549	Belongs to the carbamate kinase family
D4A92_RS24070	COG0563	adenylate kinase activity
D4A92_RS24080	COG2217	Heavy metal translocating P-type atpase
D4A92_RS24095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D4A92_RS24100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D4A92_RS24110	COG2132	Multicopper oxidase
D4A92_RS24155	COG3328	transposase activity
D4A92_RS24235	COG0596	Alpha beta hydrolase
D4A92_RS24240	COG5001	Diguanylate cyclase
D4A92_RS24245	COG3447	MASE1 domain protein
D4A92_RS24245	COG5001	Diguanylate cyclase
D4A92_RS24245	COG5002	protein histidine kinase activity
D4A92_RS24255	COG0840	transmembrane signaling receptor activity
D4A92_RS24260	COG2197	response regulator
D4A92_RS24265	COG3706	GGDEF domain
D4A92_RS24270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D4A92_RS24280	COG0640	Transcriptional regulator
D4A92_RS24285	COG0640	Transcriptional regulator
D4A92_RS24290	COG2203	Gaf domain
D4A92_RS24290	COG3706	GGDEF domain
D4A92_RS24290	COG4251	negative regulation of phosphorylation
D4A92_RS24290	COG5001	Diguanylate cyclase
D4A92_RS24295	COG2972	Histidine kinase
D4A92_RS24295	COG0840	transmembrane signaling receptor activity
D4A92_RS24305	COG1278	Cold shock
D4A92_RS24315	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS24350	COG2814	Major facilitator Superfamily
D4A92_RS24360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
D4A92_RS24400	COG0741	lytic transglycosylase activity
D4A92_RS24405	COG3838	Conjugal transfer protein Trbc
D4A92_RS24415	COG3451	type IV secretory pathway VirB4
D4A92_RS24420	COG0741	lytic transglycosylase activity
D4A92_RS24445	COG2948	multi-organism process
D4A92_RS24450	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
D4A92_RS24495	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS24535	COG4974	Belongs to the 'phage' integrase family
D4A92_RS24540	COG0517	IMP dehydrogenase activity
D4A92_RS24545	COG4467	Involved in initiation control of chromosome replication
D4A92_RS24565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS24575	COG0640	Transcriptional regulator
D4A92_RS24615	COG2203	Gaf domain
D4A92_RS24615	COG3706	GGDEF domain
D4A92_RS24615	COG4251	negative regulation of phosphorylation
D4A92_RS24615	COG5001	Diguanylate cyclase
D4A92_RS24630	COG5001	Diguanylate cyclase
D4A92_RS24630	COG4251	negative regulation of phosphorylation
D4A92_RS24630	COG3706	GGDEF domain
D4A92_RS24630	COG2203	Gaf domain
D4A92_RS24635	COG1278	Cold shock
D4A92_RS24645	COG0640	Transcriptional regulator
D4A92_RS24650	COG1475	DNA binding
D4A92_RS24655	COG1192	Involved in chromosome partitioning
D4A92_RS24660	COG3916	Acyl-homoserine-lactone synthase
D4A92_RS24665	COG4962	Type ii secretion system protein e
D4A92_RS24670	COG3838	Conjugal transfer protein Trbc
D4A92_RS24675	COG5268	conjugation
D4A92_RS24680	COG3451	type IV secretory pathway VirB4
D4A92_RS24685	COG5314	conjugation
D4A92_RS24695	COG3846	protein secretion by the type IV secretion system
D4A92_RS24710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D4A92_RS24725	COG1126	abc transporter atp-binding protein
D4A92_RS24735	COG1609	Transcriptional regulator
D4A92_RS24740	COG3284	Transcriptional regulator
D4A92_RS24745	COG1063	alcohol dehydrogenase
D4A92_RS24785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D4A92_RS24790	COG0736	holo-[acyl-carrier-protein] synthase activity
D4A92_RS24825	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D4A92_RS24870	COG1320	monovalent cation:proton antiporter activity
D4A92_RS24885	COG0651	ATP synthesis coupled electron transport
D4A92_RS24890	COG0651	ATP synthesis coupled electron transport
D4A92_RS24895	COG0651	ATP synthesis coupled electron transport
D4A92_RS24900	COG1028	Short-chain dehydrogenase reductase Sdr
D4A92_RS24910	COG2610	gluconate transmembrane transporter activity
D4A92_RS24960	COG4644	lycopene metabolic process
D4A92_RS24970	COG4644	lycopene metabolic process
D4A92_RS24975	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D4A92_RS25020	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD