locus-tag	class	description
ALSL_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ALSL_RS00020	COG0187	DNA topoisomerase II activity
ALSL_RS00060	COG2091	lysine biosynthetic process via aminoadipic acid
ALSL_RS00065	COG2198	Histidine kinase
ALSL_RS00065	COG0784	Response regulator, receiver
ALSL_RS00065	COG2205	protein histidine kinase activity
ALSL_RS00085	COG0477	Major facilitator Superfamily
ALSL_RS00095	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALSL_RS00120	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALSL_RS00125	COG3186	Phenylalanine-4-hydroxylase
ALSL_RS00130	COG1522	sequence-specific DNA binding
ALSL_RS00150	COG3546	catalase activity
ALSL_RS00155	COG1881	PFAM PEBP family protein
ALSL_RS00185	COG1968	undecaprenyl-diphosphatase activity
ALSL_RS00190	COG0174	glutamine synthetase
ALSL_RS00210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ALSL_RS00210	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ALSL_RS00220	COG4771	TonB-dependent receptor
ALSL_RS00230	COG3852	Histidine kinase
ALSL_RS00235	COG2204	response regulator
ALSL_RS00250	COG0183	Belongs to the thiolase family
ALSL_RS00260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_RS00285	COG1166	arginine decarboxylase activity
ALSL_RS00290	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS00300	COG4221	oxidoreductase activity
ALSL_RS00310	COG0018	arginyl-trna synthetase
ALSL_RS00315	COG2003	Belongs to the UPF0758 family
ALSL_RS00320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ALSL_RS00325	COG0756	dUTP diphosphatase activity
ALSL_RS00345	COG0708	Exodeoxyribonuclease III
ALSL_RS00350	COG2223	nitrite transmembrane transporter activity
ALSL_RS00365	COG0739	heme binding
ALSL_RS00370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ALSL_RS00415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ALSL_RS00420	COG1984	allophanate hydrolase subunit 2
ALSL_RS00425	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ALSL_RS00430	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_RS00430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALSL_RS00435	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALSL_RS00440	COG0752	glycyl-tRNA synthetase alpha subunit
ALSL_RS00455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ALSL_RS00460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ALSL_RS00465	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
ALSL_RS00470	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ALSL_RS00475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ALSL_RS00480	COG0210	DNA helicase
ALSL_RS00485	COG1435	thymidine kinase activity
ALSL_RS00500	COG3549	Plasmid maintenance system killer
ALSL_RS00505	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ALSL_RS00510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ALSL_RS00530	COG1131	(ABC) transporter
ALSL_RS00540	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALSL_RS00540	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ALSL_RS00545	COG1506	peptidase
ALSL_RS00545	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_RS00565	COG1201	RNA secondary structure unwinding
ALSL_RS00575	COG0697	spore germination
ALSL_RS00580	COG1187	pseudouridine synthase activity
ALSL_RS00590	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_RS00595	COG0667	Aldo Keto reductase
ALSL_RS00610	COG0531	amino acid
ALSL_RS00615	COG1063	alcohol dehydrogenase
ALSL_RS00620	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ALSL_RS00625	COG0511	ligase activity, forming carbon-carbon bonds
ALSL_RS00630	COG0439	Biotin carboxylase
ALSL_RS00635	COG2264	protein methyltransferase activity
ALSL_RS00690	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS00700	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ALSL_RS00710	COG0210	DNA helicase
ALSL_RS00715	COG0436	Aminotransferase
ALSL_RS00725	COG0668	transmembrane transport
ALSL_RS00745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALSL_RS00750	COG1490	D-aminoacyl-tRNA deacylase activity
ALSL_RS00770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ALSL_RS00790	COG1215	transferase activity, transferring glycosyl groups
ALSL_RS00805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALSL_RS00805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ALSL_RS00820	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ALSL_RS00825	COG0242	peptide deformylase activity
ALSL_RS00835	COG0758	DNA mediated transformation
ALSL_RS00845	COG0009	L-threonylcarbamoyladenylate synthase
ALSL_RS00855	COG0151	Belongs to the GarS family
ALSL_RS00870	COG2816	NAD+ diphosphatase activity
ALSL_RS00875	COG0316	Belongs to the HesB IscA family
ALSL_RS00890	COG1051	belongs to the nudix hydrolase family
ALSL_RS00900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ALSL_RS00905	COG0166	Belongs to the GPI family
ALSL_RS00910	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ALSL_RS00915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ALSL_RS00920	COG0720	synthase
ALSL_RS00930	COG1538	Outer membrane efflux protein
ALSL_RS00935	COG1566	PFAM secretion protein HlyD family protein
ALSL_RS00940	COG2814	Major facilitator Superfamily
ALSL_RS00945	COG0662	Cupin 2, conserved barrel domain protein
ALSL_RS00945	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ALSL_RS00970	COG0626	cystathionine gamma-synthase activity
ALSL_RS00990	COG0438	transferase activity, transferring glycosyl groups
ALSL_RS00990	COG1216	Glycosyl transferase, family 2
ALSL_RS01015	COG2086	electron transfer activity
ALSL_RS01035	COG0154	amidase activity
ALSL_RS01055	COG1127	ABC transporter
ALSL_RS01060	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALSL_RS01065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ALSL_RS01070	COG0509	glycine decarboxylation via glycine cleavage system
ALSL_RS01075	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
ALSL_RS01095	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ALSL_RS01100	COG0463	Glycosyl transferase, family 2
ALSL_RS01105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALSL_RS01110	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ALSL_RS01125	COG1309	transcriptional regulator
ALSL_RS01140	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ALSL_RS01145	COG1518	maintenance of DNA repeat elements
ALSL_RS01145	COG1468	defense response to virus
ALSL_RS01180	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
ALSL_RS01185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALSL_RS01190	COG0626	cystathionine gamma-synthase activity
ALSL_RS01195	COG0460	homoserine dehydrogenase
ALSL_RS01195	COG0527	aspartate kinase activity
ALSL_RS01200	COG0531	amino acid
ALSL_RS01220	COG1760	l-serine dehydratase
ALSL_RS01235	COG3038	cytochrome b561
ALSL_RS01250	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALSL_RS01260	COG0795	lipopolysaccharide-transporting ATPase activity
ALSL_RS01285	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ALSL_RS01295	COG0583	DNA-binding transcription factor activity
ALSL_RS01300	COG0308	aminopeptidase N
ALSL_RS01310	COG1214	PFAM Peptidase M22, glycoprotease
ALSL_RS01315	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALSL_RS01320	COG2059	Chromate
ALSL_RS01330	COG2259	Doxx family
ALSL_RS01340	COG1199	ATP-dependent helicase activity
ALSL_RS01355	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ALSL_RS01370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALSL_RS01380	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
ALSL_RS01385	COG0792	nuclease activity
ALSL_RS01390	COG3107	peptidoglycan biosynthetic process
ALSL_RS01395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ALSL_RS01425	COG4772	TonB-dependent receptor
ALSL_RS01430	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_RS01435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
ALSL_RS01445	COG5006	permease, DMT superfamily
ALSL_RS01450	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_RS01455	COG0697	spore germination
ALSL_RS01465	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALSL_RS01470	COG0308	aminopeptidase N
ALSL_RS01495	COG4625	pathogenesis
ALSL_RS01495	COG3240	lipase activity
ALSL_RS01515	COG1040	competence protein
ALSL_RS01520	COG0840	transmembrane signaling receptor activity
ALSL_RS01575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ALSL_RS01580	COG0440	acetolactate synthase activity
ALSL_RS01585	COG0028	Belongs to the TPP enzyme family
ALSL_RS01595	COG0129	dihydroxy-acid dehydratase activity
ALSL_RS01600	COG0473	3-isopropylmalate dehydrogenase activity
ALSL_RS01610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ALSL_RS01635	COG0527	aspartate kinase activity
ALSL_RS01635	COG0460	homoserine dehydrogenase
ALSL_RS01640	COG0737	Belongs to the 5'-nucleotidase family
ALSL_RS01655	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ALSL_RS01660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALSL_RS01675	COG3012	SEC-C Motif Domain Protein
ALSL_RS01720	COG3245	cytochrome
ALSL_RS01745	COG0837	glucose binding
ALSL_RS01750	COG2723	6-phospho-beta-galactosidase activity
ALSL_RS01755	COG3842	ATPase activity
ALSL_RS01760	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS01785	COG3100	YcgL domain-containing protein
ALSL_RS01795	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_RS01820	COG4772	TonB-dependent receptor
ALSL_RS01825	COG0584	glycerophosphoryl diester phosphodiesterase
ALSL_RS01845	COG1565	acr, cog1565
ALSL_RS01845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ALSL_RS01880	COG0109	protoheme IX farnesyltransferase activity
ALSL_RS01885	COG0745	RESPONSE REGULATOR receiver
ALSL_RS01890	COG0642	Histidine kinase
ALSL_RS01935	COG0586	Pfam SNARE associated Golgi protein
ALSL_RS01940	COG0358	DNA primase activity
ALSL_RS01960	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ALSL_RS01970	COG0302	gtp cyclohydrolase
ALSL_RS01975	COG1322	Protein conserved in bacteria
ALSL_RS01985	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALSL_RS01995	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ALSL_RS02005	COG0543	2 iron, 2 sulfur cluster binding
ALSL_RS02005	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ALSL_RS02025	COG0456	acetyltransferase
ALSL_RS02045	COG1162	GTPase activity
ALSL_RS02050	COG2226	methyltransferase
ALSL_RS02055	COG0280	phosphate acetyltransferase
ALSL_RS02055	COG0281	malic enzyme
ALSL_RS02060	COG0469	pyruvate kinase activity
ALSL_RS02080	COG0438	transferase activity, transferring glycosyl groups
ALSL_RS02130	COG1506	peptidase
ALSL_RS02130	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_RS02155	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ALSL_RS02165	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ALSL_RS02170	COG1605	Chorismate mutase
ALSL_RS02170	COG0077	Prephenate dehydratase
ALSL_RS02190	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
ALSL_RS02195	COG0322	excinuclease ABC activity
ALSL_RS02210	COG0582	viral genome integration into host DNA
ALSL_RS02260	COG1396	sequence-specific DNA binding
ALSL_RS02265	COG0583	DNA-binding transcription factor activity
ALSL_RS02305	COG2132	Multicopper oxidase
ALSL_RS02310	COG0745	RESPONSE REGULATOR receiver
ALSL_RS02315	COG5002	protein histidine kinase activity
ALSL_RS02325	COG0640	Transcriptional regulator
ALSL_RS02340	COG0798	PFAM Bile acid sodium symporter
ALSL_RS02350	COG1695	Transcriptional regulator
ALSL_RS02450	COG3039	Transposase
ALSL_RS02465	COG0789	Transcriptional regulator
ALSL_RS02475	COG0672	)-iron permease
ALSL_RS02485	COG0671	phosphoesterase, PA-phosphatase related
ALSL_RS02510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_RS02550	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALSL_RS02585	COG2132	Multicopper oxidase
ALSL_RS02690	COG3311	Transcriptional regulator
ALSL_RS02695	COG1569	PIN domain
ALSL_RS02700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALSL_RS02780	COG3039	Transposase
ALSL_RS02835	COG3039	Transposase
ALSL_RS02865	COG0789	Transcriptional regulator
ALSL_RS02910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ALSL_RS02920	COG0789	Transcriptional regulator
ALSL_RS02935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ALSL_RS02940	COG0629	single-stranded DNA binding
ALSL_RS03005	COG0457	Tetratricopeptide repeat
ALSL_RS03015	COG0779	Required for maturation of 30S ribosomal subunits
ALSL_RS03020	COG2251	uridine kinase activity
ALSL_RS03020	COG0195	Participates in both transcription termination and antitermination
ALSL_RS03040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ALSL_RS03045	COG1185	polyribonucleotide nucleotidyltransferase activity
ALSL_RS03055	COG3243	poly(R)-hydroxyalkanoic acid synthase
ALSL_RS03060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ALSL_RS03075	COG0071	Belongs to the small heat shock protein (HSP20) family
ALSL_RS03090	COG0604	alcohol dehydrogenase
ALSL_RS03120	COG2850	peptidyl-arginine hydroxylation
ALSL_RS03125	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ALSL_RS03130	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALSL_RS03135	COG0175	sulfate reduction
ALSL_RS03140	COG2046	Belongs to the sulfate adenylyltransferase family
ALSL_RS03140	COG0529	Catalyzes the synthesis of activated sulfate
ALSL_RS03150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ALSL_RS03150	COG1648	precorrin-2 dehydrogenase activity
ALSL_RS03180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ALSL_RS03185	COG1561	YicC-like family, N-terminal region
ALSL_RS03190	COG0194	GDP metabolic process
ALSL_RS03195	COG1127	ABC transporter
ALSL_RS03200	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
ALSL_RS03220	COG2853	Lipoprotein
ALSL_RS03225	COG1758	RNA polymerase activity
ALSL_RS03230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ALSL_RS03240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ALSL_RS03250	COG0254	rRNA binding
ALSL_RS03255	COG0372	Belongs to the citrate synthase family
ALSL_RS03275	COG2022	thiamine diphosphate biosynthetic process
ALSL_RS03305	COG2205	protein histidine kinase activity
ALSL_RS03310	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ALSL_RS03315	COG3278	Belongs to the heme-copper respiratory oxidase family
ALSL_RS03330	COG2010	Cytochrome c
ALSL_RS03350	COG2217	Heavy metal translocating P-type atpase
ALSL_RS03365	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ALSL_RS03375	COG0277	FAD linked oxidase domain protein
ALSL_RS03420	COG3483	tryptophan 2,3-dioxygenase activity
ALSL_RS03435	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
ALSL_RS03455	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
ALSL_RS03470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_RS03500	COG1677	Flagellar hook-basal body complex protein FliE
ALSL_RS03510	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ALSL_RS03555	COG1338	Plays a role in the flagellum-specific transport system
ALSL_RS03560	COG1987	bacterial-type flagellum assembly
ALSL_RS03575	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ALSL_RS03595	COG0745	RESPONSE REGULATOR receiver
ALSL_RS03600	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
ALSL_RS03605	COG0643	Histidine kinase
ALSL_RS03605	COG2198	Histidine kinase
ALSL_RS03605	COG0784	Response regulator, receiver
ALSL_RS03610	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ALSL_RS03615	COG1360	Flagellar Motor Protein
ALSL_RS03620	COG0835	chemotaxis
ALSL_RS03625	COG0842	Transport permease protein
ALSL_RS03630	COG0842	Transport permease protein
ALSL_RS03630	COG1129	ABC transporter
ALSL_RS03635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_RS03645	COG4993	Dehydrogenase
ALSL_RS03660	COG2814	Major facilitator Superfamily
ALSL_RS03685	COG4771	TonB-dependent receptor
ALSL_RS03700	COG0643	Histidine kinase
ALSL_RS03700	COG2198	Histidine kinase
ALSL_RS03705	COG0835	chemotaxis
ALSL_RS03710	COG0840	transmembrane signaling receptor activity
ALSL_RS03715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ALSL_RS03720	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ALSL_RS03725	COG2201	protein-glutamate methylesterase activity
ALSL_RS03750	COG2080	2 iron, 2 sulfur cluster binding
ALSL_RS03760	COG0527	aspartate kinase activity
ALSL_RS03770	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ALSL_RS03785	COG0729	surface antigen
ALSL_RS03795	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ALSL_RS03805	COG1368	sulfuric ester hydrolase activity
ALSL_RS03820	COG0783	Belongs to the Dps family
ALSL_RS03825	COG1643	Atp-dependent helicase
ALSL_RS03840	COG2855	membrane
ALSL_RS03845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ALSL_RS03925	COG1960	acyl-CoA dehydrogenase activity
ALSL_RS03940	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ALSL_RS03955	COG0693	protein deglycase activity
ALSL_RS03960	COG3590	peptidase
ALSL_RS03980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALSL_RS04005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ALSL_RS04005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ALSL_RS04010	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ALSL_RS04025	COG0010	Belongs to the arginase family
ALSL_RS04030	COG2211	Major facilitator Superfamily
ALSL_RS04035	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ALSL_RS04045	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ALSL_RS04050	COG0071	Belongs to the small heat shock protein (HSP20) family
ALSL_RS04055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ALSL_RS04060	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ALSL_RS04075	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ALSL_RS04090	COG1137	ATPase activity
ALSL_RS04105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
ALSL_RS04120	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ALSL_RS04135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ALSL_RS04150	COG0628	permease
ALSL_RS04160	COG0508	dehydrogenase complex catalyzes the overall conversion of
ALSL_RS04165	COG3264	Mechanosensitive ion channel
ALSL_RS04165	COG1196	nuclear chromosome segregation
ALSL_RS04170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALSL_RS04175	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALSL_RS04190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ALSL_RS04215	COG1131	(ABC) transporter
ALSL_RS04220	COG2186	Transcriptional regulator
ALSL_RS04230	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ALSL_RS04245	COG2879	small protein
ALSL_RS04250	COG1966	Carbon starvation protein
ALSL_RS04260	COG1309	transcriptional regulator
ALSL_RS04290	COG4638	Rieske (2fe-2S)
ALSL_RS04295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ALSL_RS04295	COG4221	oxidoreductase activity
ALSL_RS04295	COG3321	synthase
ALSL_RS04295	COG0604	alcohol dehydrogenase
ALSL_RS04300	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS04330	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALSL_RS04350	COG1802	Transcriptional regulator
ALSL_RS04355	COG4638	Rieske (2fe-2S)
ALSL_RS04360	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ALSL_RS04365	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS04370	COG0163	prenyltransferase activity
ALSL_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_RS04455	COG0242	peptide deformylase activity
ALSL_RS04460	COG0284	orotidine-5'-phosphate decarboxylase activity
ALSL_RS04465	COG0488	(ABC) transporter
ALSL_RS04475	COG0483	inositol monophosphate 1-phosphatase activity
ALSL_RS04480	COG0494	nUDIX hydrolase
ALSL_RS04490	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALSL_RS04490	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ALSL_RS04525	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
ALSL_RS04550	COG0252	asparaginase activity
ALSL_RS04555	COG1960	acyl-CoA dehydrogenase activity
ALSL_RS04560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_RS04575	COG1295	ribonuclease BN
ALSL_RS04580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_RS04585	COG1254	Belongs to the acylphosphatase family
ALSL_RS04590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ALSL_RS04605	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
ALSL_RS04610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ALSL_RS04620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ALSL_RS04625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ALSL_RS04630	COG0193	aminoacyl-tRNA hydrolase activity
ALSL_RS04635	COG0012	GTP binding
ALSL_RS04640	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
ALSL_RS04650	COG1946	Acyl-CoA thioesterase
ALSL_RS04665	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ALSL_RS04665	COG0116	Belongs to the methyltransferase superfamily
ALSL_RS04675	COG0537	adenosine 5'-monophosphoramidase activity
ALSL_RS04690	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ALSL_RS04695	COG0386	Belongs to the glutathione peroxidase family
ALSL_RS04700	COG1047	Peptidyl-prolyl cis-trans
ALSL_RS04740	COG0714	Associated with various cellular activities
ALSL_RS04755	COG1399	metal-binding, possibly nucleic acid-binding protein
ALSL_RS04760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ALSL_RS04765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ALSL_RS04785	COG1530	ribonuclease E activity
ALSL_RS04790	COG0564	pseudouridine synthase activity
ALSL_RS04795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ALSL_RS04805	COG3028	Belongs to the UPF0307 family
ALSL_RS04810	COG0312	modulator of DNA gyrase
ALSL_RS04820	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ALSL_RS04825	COG0539	negative regulation of cytoplasmic translation
ALSL_RS04830	COG0776	regulation of translation
ALSL_RS04835	COG1131	(ABC) transporter
ALSL_RS04855	COG1999	signal sequence binding
ALSL_RS04860	COG2363	Small membrane protein
ALSL_RS04885	COG0159	tryptophan synthase activity
ALSL_RS04890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ALSL_RS04910	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALSL_RS04920	COG0735	belongs to the Fur family
ALSL_RS04930	COG1230	cation diffusion facilitator family transporter
ALSL_RS04950	COG2204	response regulator
ALSL_RS04980	COG3685	Protein conserved in bacteria
ALSL_RS04995	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_RS05000	COG0741	lytic transglycosylase activity
ALSL_RS05000	COG1388	LysM domain
ALSL_RS05005	COG0688	phosphatidylethanolamine metabolic process
ALSL_RS05010	COG2890	protein-(glutamine-N5) methyltransferase activity
ALSL_RS05020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ALSL_RS05025	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ALSL_RS05050	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ALSL_RS05060	COG0557	exoribonuclease II activity
ALSL_RS05065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ALSL_RS05075	COG0704	Plays a role in the regulation of phosphate uptake
ALSL_RS05090	COG0573	inorganic phosphate transmembrane transporter activity
ALSL_RS05095	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ALSL_RS05100	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALSL_RS05110	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ALSL_RS05115	COG2878	Part of a membrane complex involved in electron transport
ALSL_RS05125	COG2223	nitrite transmembrane transporter activity
ALSL_RS05130	COG1011	Hydrolase
ALSL_RS05135	COG1349	DNA-binding transcription factor activity
ALSL_RS05155	COG1555	photosystem II stabilization
ALSL_RS05170	COG0791	NLP P60 protein
ALSL_RS05180	COG1113	amino acid transport
ALSL_RS05185	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
ALSL_RS05210	COG4774	siderophore transport
ALSL_RS05220	COG3590	peptidase
ALSL_RS05230	COG1183	phosphatidylcholine synthase activity
ALSL_RS05255	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ALSL_RS05265	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_RS05270	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALSL_RS05275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_RS05285	COG0750	zinc metalloprotease
ALSL_RS05290	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ALSL_RS05295	COG0575	Belongs to the CDS family
ALSL_RS05300	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ALSL_RS05320	COG0052	Belongs to the universal ribosomal protein uS2 family
ALSL_RS05325	COG0024	Methionine aminopeptidase
ALSL_RS05330	COG1802	Transcriptional regulator
ALSL_RS05335	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ALSL_RS05340	COG0346	lactoylglutathione lyase activity
ALSL_RS05345	COG0625	glutathione transferase activity
ALSL_RS05355	COG4569	acetaldehyde dehydrogenase (acetylating) activity
ALSL_RS05395	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS05415	COG4638	Rieske (2fe-2S)
ALSL_RS05420	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
ALSL_RS05425	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_RS05430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_RS05435	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALSL_RS05440	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS05470	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
ALSL_RS05475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
ALSL_RS05480	COG2171	N-acyltransferase activity
ALSL_RS05485	COG1393	Belongs to the ArsC family
ALSL_RS05490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_RS05515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ALSL_RS05520	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
ALSL_RS05530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ALSL_RS05535	COG4572	Cation transport regulator
ALSL_RS05545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
ALSL_RS05550	COG2894	cell division
ALSL_RS05570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_RS05580	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
ALSL_RS05625	COG2867	negative regulation of translational initiation
ALSL_RS05630	COG2914	Belongs to the UPF0125 (RnfH) family
ALSL_RS05635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALSL_RS05640	COG0735	belongs to the Fur family
ALSL_RS05645	COG4585	Histidine kinase
ALSL_RS05650	COG2197	response regulator
ALSL_RS05660	COG1420	regulation of RNA biosynthetic process
ALSL_RS05665	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ALSL_RS05670	COG0443	Heat shock 70 kDa protein
ALSL_RS05695	COG0505	Belongs to the CarA family
ALSL_RS05700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ALSL_RS05705	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ALSL_RS05710	COG0481	GTPase activity
ALSL_RS05715	COG0681	Belongs to the peptidase S26 family
ALSL_RS05735	COG1381	Involved in DNA repair and RecF pathway recombination
ALSL_RS05755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ALSL_RS05760	COG2954	triphosphatase activity
ALSL_RS05765	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_RS05770	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ALSL_RS05775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ALSL_RS05780	COG1278	Cold shock
ALSL_RS05785	COG0475	glutathione-regulated potassium exporter activity
ALSL_RS05790	COG0477	Major facilitator Superfamily
ALSL_RS05795	COG4585	Histidine kinase
ALSL_RS05800	COG2197	response regulator
ALSL_RS05815	COG0544	peptidyl-prolyl cis-trans isomerase activity
ALSL_RS05820	COG0740	serine-type endopeptidase activity
ALSL_RS05825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ALSL_RS05835	COG0776	regulation of translation
ALSL_RS05850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALSL_RS05855	COG0791	NLP P60 protein
ALSL_RS05855	COG1388	LysM domain
ALSL_RS05870	COG0328	RNA-DNA hybrid ribonuclease activity
ALSL_RS05875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ALSL_RS05895	COG0477	Major facilitator Superfamily
ALSL_RS05910	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ALSL_RS05915	COG1472	Belongs to the glycosyl hydrolase 3 family
ALSL_RS05920	COG2166	iron-sulfur cluster assembly
ALSL_RS05940	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ALSL_RS05950	COG0137	argininosuccinate synthase activity
ALSL_RS05955	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ALSL_RS05960	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ALSL_RS05975	COG0165	Argininosuccinate lyase
ALSL_RS05985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ALSL_RS05990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALSL_RS05995	COG3844	kynureninase activity
ALSL_RS06010	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALSL_RS06030	COG2153	protein acetylation
ALSL_RS06040	COG1228	amidohydrolase
ALSL_RS06070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ALSL_RS06090	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
ALSL_RS06095	COG2132	Multicopper oxidase
ALSL_RS06100	COG3667	copper resistance
ALSL_RS06110	COG5001	Diguanylate cyclase
ALSL_RS06110	COG5002	protein histidine kinase activity
ALSL_RS06115	COG2982	Protein involved in outer membrane biogenesis
ALSL_RS06120	COG1764	response to oxidative stress
ALSL_RS06135	COG0384	phenazine biosynthesis protein PhzF
ALSL_RS06155	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ALSL_RS06160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ALSL_RS06185	COG1063	alcohol dehydrogenase
ALSL_RS06195	COG1923	regulation of RNA biosynthetic process
ALSL_RS06200	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ALSL_RS06215	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_RS06225	COG1012	belongs to the aldehyde dehydrogenase family
ALSL_RS06245	COG1196	nuclear chromosome segregation
ALSL_RS06245	COG3264	Mechanosensitive ion channel
ALSL_RS06250	COG1515	deoxyribonuclease V activity
ALSL_RS06285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALSL_RS06295	COG2813	Specifically methylates the guanine in position
ALSL_RS06300	COG1187	pseudouridine synthase activity
ALSL_RS06345	COG3039	Transposase
ALSL_RS06355	COG4191	Histidine kinase
ALSL_RS06355	COG0784	Response regulator, receiver
ALSL_RS06370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ALSL_RS06395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_RS06405	COG0142	geranyltranstransferase activity
ALSL_RS06410	COG1722	exodeoxyribonuclease VII activity
ALSL_RS06420	COG0825	malonyl-CoA metabolic process
ALSL_RS06425	COG1619	proteins homologs of microcin C7 resistance protein MccF
ALSL_RS06430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ALSL_RS06435	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ALSL_RS06445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ALSL_RS06450	COG0753	catalase activity
ALSL_RS06465	COG0824	Thioesterase
ALSL_RS06470	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ALSL_RS06480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ALSL_RS06485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ALSL_RS06500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ALSL_RS06505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_RS06510	COG3265	gluconokinase activity
ALSL_RS06520	COG2833	Protein of unknown function (DUF455)
ALSL_RS06535	COG2986	histidine ammonia-lyase
ALSL_RS06555	COG0406	alpha-ribazole phosphatase activity
ALSL_RS06560	COG0285	dihydrofolate synthase activity
ALSL_RS06585	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ALSL_RS06585	COG0316	Belongs to the HesB IscA family
ALSL_RS06605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_RS06610	COG2957	Belongs to the agmatine deiminase family
ALSL_RS06620	COG0488	(ABC) transporter
ALSL_RS06630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ALSL_RS06640	COG0367	asparagine synthase
ALSL_RS06660	COG2350	Protein conserved in bacteria
ALSL_RS06690	COG0305	Participates in initiation and elongation during chromosome replication
ALSL_RS06700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_RS06705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALSL_RS06715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
ALSL_RS06725	COG0745	RESPONSE REGULATOR receiver
ALSL_RS06730	COG4783	chaperone-mediated protein folding
ALSL_RS06735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ALSL_RS06745	COG0473	3-isopropylmalate dehydrogenase activity
ALSL_RS06755	COG0352	thiamine-phosphate diphosphorylase activity
ALSL_RS06755	COG0351	phosphomethylpyrimidine kinase
ALSL_RS06760	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ALSL_RS06765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALSL_RS06775	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ALSL_RS06785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
ALSL_RS06850	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ALSL_RS06855	COG0360	Binds together with S18 to 16S ribosomal RNA
ALSL_RS06860	COG0316	Belongs to the HesB IscA family
ALSL_RS06880	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS06885	COG0288	reversible hydration of carbon dioxide
ALSL_RS06895	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ALSL_RS06900	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALSL_RS06905	COG0791	NLP P60 protein
ALSL_RS06915	COG2814	Major facilitator Superfamily
ALSL_RS06930	COG4221	oxidoreductase activity
ALSL_RS06940	COG2895	sulfate adenylyltransferase (ATP) activity
ALSL_RS06940	COG0529	Catalyzes the synthesis of activated sulfate
ALSL_RS06945	COG0175	sulfate reduction
ALSL_RS06955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ALSL_RS06960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ALSL_RS06965	COG0719	Fe-S assembly protein
ALSL_RS06970	COG0396	ATPase activity
ALSL_RS06980	COG0719	Fe-S assembly protein
ALSL_RS06990	COG0347	Belongs to the P(II) protein family
ALSL_RS06995	COG0004	ammonium transporteR
ALSL_RS07000	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ALSL_RS07010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ALSL_RS07015	COG1360	Flagellar Motor Protein
ALSL_RS07030	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ALSL_RS07035	COG1862	Preprotein translocase
ALSL_RS07050	COG2835	tetraacyldisaccharide 4'-kinase activity
ALSL_RS07075	COG2814	Major facilitator Superfamily
ALSL_RS07080	COG0579	oxidoreductase
ALSL_RS07085	COG2969	positive regulation of protein catabolic process
ALSL_RS07090	COG0625	glutathione transferase activity
ALSL_RS07095	COG2857	Cytochrome c1
ALSL_RS07100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ALSL_RS07105	COG0723	plastoquinol--plastocyanin reductase activity
ALSL_RS07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_RS07120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALSL_RS07120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ALSL_RS07135	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ALSL_RS07140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ALSL_RS07150	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ALSL_RS07165	COG0643	Histidine kinase
ALSL_RS07165	COG0784	Response regulator, receiver
ALSL_RS07165	COG2198	Histidine kinase
ALSL_RS07165	COG0643	Histidine kinase
ALSL_RS07165	COG0784	Response regulator, receiver
ALSL_RS07165	COG2198	Histidine kinase
ALSL_RS07170	COG0840	transmembrane signaling receptor activity
ALSL_RS07190	COG0189	ligase activity
ALSL_RS07210	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ALSL_RS07245	COG0762	integral membrane protein
ALSL_RS07250	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
ALSL_RS07260	COG0732	type I restriction modification DNA specificity domain
ALSL_RS07270	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ALSL_RS07280	COG0432	Pfam Uncharacterised protein family UPF0047
ALSL_RS07290	COG0572	uridine kinase
ALSL_RS07300	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ALSL_RS07310	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_RS07320	COG1914	H( )-stimulated, divalent metal cation uptake system
ALSL_RS07330	COG0343	queuine tRNA-ribosyltransferase activity
ALSL_RS07335	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ALSL_RS07340	COG2197	response regulator
ALSL_RS07345	COG4585	Histidine kinase
ALSL_RS07355	COG1131	(ABC) transporter
ALSL_RS07360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALSL_RS07365	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ALSL_RS07380	COG0277	FAD linked oxidase domain protein
ALSL_RS07385	COG0415	Belongs to the DNA photolyase family
ALSL_RS07390	COG3300	MHYT domain
ALSL_RS07390	COG5001	Diguanylate cyclase
ALSL_RS07400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALSL_RS07415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_RS07435	COG3023	N-Acetylmuramoyl-L-alanine amidase
ALSL_RS07445	COG0471	metal ion transport
ALSL_RS07445	COG3273	potassium ion transport
ALSL_RS07460	COG2169	Transcriptional regulator
ALSL_RS07460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ALSL_RS07485	COG2132	Multicopper oxidase
ALSL_RS07520	COG2031	fatty acid transporter
ALSL_RS07550	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ALSL_RS07550	COG0519	Catalyzes the synthesis of GMP from XMP
ALSL_RS07560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ALSL_RS07570	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ALSL_RS07580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ALSL_RS07605	COG0105	UTP biosynthetic process
ALSL_RS07615	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALSL_RS07615	COG1024	Enoyl-CoA hydratase
ALSL_RS07620	COG0183	Belongs to the thiolase family
ALSL_RS07635	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ALSL_RS07645	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ALSL_RS07710	COG0582	viral genome integration into host DNA
ALSL_RS07720	COG1286	toxin biosynthetic process
ALSL_RS07730	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ALSL_RS07735	COG0489	protein tyrosine kinase activity
ALSL_RS07745	COG4535	Mg2 and Co2 transporter CorC
ALSL_RS07755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALSL_RS07765	COG1702	phosphate starvation-inducible protein PhoH
ALSL_RS07770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ALSL_RS07800	COG2076	Multidrug Resistance protein
ALSL_RS07825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALSL_RS07830	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ALSL_RS07850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ALSL_RS07855	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ALSL_RS07865	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ALSL_RS07880	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS07925	COG0625	glutathione transferase activity
ALSL_RS07935	COG1960	acyl-CoA dehydrogenase activity
ALSL_RS07940	COG0697	spore germination
ALSL_RS07955	COG0028	Belongs to the TPP enzyme family
ALSL_RS07965	COG0477	Major facilitator Superfamily
ALSL_RS07990	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ALSL_RS08010	COG0717	Belongs to the dCTP deaminase family
ALSL_RS08015	COG1674	ftsk spoiiie
ALSL_RS08020	COG0686	Belongs to the AlaDH PNT family
ALSL_RS08025	COG0492	ferredoxin-NADP+ reductase activity
ALSL_RS08035	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
ALSL_RS08075	COG3706	GGDEF domain
ALSL_RS08095	COG4191	Histidine kinase
ALSL_RS08095	COG0784	Response regulator, receiver
ALSL_RS08105	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS08115	COG0039	L-malate dehydrogenase activity
ALSL_RS08125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ALSL_RS08145	COG0784	Response regulator, receiver
ALSL_RS08145	COG2205	protein histidine kinase activity
ALSL_RS08145	COG2198	Histidine kinase
ALSL_RS08155	COG4771	TonB-dependent receptor
ALSL_RS08160	COG2610	gluconate transmembrane transporter activity
ALSL_RS08170	COG1609	Transcriptional regulator
ALSL_RS08185	COG0667	Aldo Keto reductase
ALSL_RS08190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ALSL_RS08200	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ALSL_RS08220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ALSL_RS08225	COG1546	Belongs to the CinA family
ALSL_RS08240	COG0861	Integral membrane protein TerC family
ALSL_RS08250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ALSL_RS08265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_RS08275	COG3384	dioxygenase
ALSL_RS08285	COG1297	OPT oligopeptide transporter protein
ALSL_RS08290	COG1132	(ABC) transporter
ALSL_RS08305	COG1640	4-alpha-glucanotransferase
ALSL_RS08310	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ALSL_RS08320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ALSL_RS08325	COG0366	Alpha amylase catalytic
ALSL_RS08330	COG0366	Alpha amylase catalytic
ALSL_RS08345	COG0167	dihydroorotate dehydrogenase activity
ALSL_RS08350	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ALSL_RS08370	COG0577	efflux transmembrane transporter activity
ALSL_RS08375	COG1136	(ABC) transporter
ALSL_RS08380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_RS08385	COG0179	Fumarylacetoacetate (FAA) hydrolase
ALSL_RS08390	COG1970	mechanosensitive ion channel activity
ALSL_RS08425	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ALSL_RS08430	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ALSL_RS08440	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ALSL_RS08445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ALSL_RS08455	COG1981	membrane
ALSL_RS08470	COG0556	nucleotide-excision repair
ALSL_RS08485	COG1611	Belongs to the LOG family
ALSL_RS08500	COG2095	MarC family integral membrane protein
ALSL_RS08525	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ALSL_RS08530	COG0237	dephospho-CoA kinase activity
ALSL_RS08535	COG5000	phosphorelay sensor kinase activity
ALSL_RS08535	COG5002	protein histidine kinase activity
ALSL_RS08540	COG0745	RESPONSE REGULATOR receiver
ALSL_RS08550	COG4181	ATPase activity
ALSL_RS08560	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ALSL_RS08570	COG3956	TIGRFAM MazG family protein
ALSL_RS08575	COG0442	prolyl-tRNA aminoacylation
ALSL_RS08595	COG0330	HflC and HflK could
ALSL_RS08600	COG0366	Alpha amylase catalytic
ALSL_RS08630	COG0047	phosphoribosylformylglycinamidine synthase activity
ALSL_RS08630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ALSL_RS08635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ALSL_RS08640	COG4974	Belongs to the 'phage' integrase family
ALSL_RS08660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ALSL_RS08665	COG0602	queuosine metabolic process
ALSL_RS08675	COG2885	chlorophyll binding
ALSL_RS08690	COG0848	biopolymer transport protein
ALSL_RS08700	COG0824	Thioesterase
ALSL_RS08705	COG2255	four-way junction helicase activity
ALSL_RS08720	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ALSL_RS08725	COG0402	S-adenosylhomocysteine deaminase activity
ALSL_RS08730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ALSL_RS08735	COG1509	lysine 2,3-aminomutase activity
ALSL_RS08755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ALSL_RS08760	COG1469	GTP cyclohydrolase I activity
ALSL_RS08785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ALSL_RS08800	COG0196	riboflavin kinase activity
ALSL_RS08805	COG0728	peptidoglycan biosynthetic process
ALSL_RS08815	COG1960	acyl-CoA dehydrogenase activity
ALSL_RS08830	COG1410	methionine synthase
ALSL_RS08830	COG0646	methionine synthase
ALSL_RS08835	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
ALSL_RS08835	COG3952	Lipid A Biosynthesis
ALSL_RS08860	COG4966	pilus assembly protein PilW
ALSL_RS08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ALSL_RS08885	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS08900	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ALSL_RS08905	COG1187	pseudouridine synthase activity
ALSL_RS08910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_RS08915	COG0436	Aminotransferase
ALSL_RS08945	COG3642	lipopolysaccharide core region biosynthetic process
ALSL_RS08950	COG0859	PFAM glycosyl transferase family 9
ALSL_RS08960	COG0477	Major facilitator Superfamily
ALSL_RS08965	COG3039	Transposase
ALSL_RS08980	COG0336	Belongs to the RNA methyltransferase TrmD family
ALSL_RS08985	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ALSL_RS08990	COG0228	four-way junction DNA binding
ALSL_RS08995	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ALSL_RS09000	COG4137	Cytochrome C assembly protein
ALSL_RS09025	COG0545	Peptidyl-prolyl cis-trans isomerase
ALSL_RS09030	COG1024	Enoyl-CoA hydratase
ALSL_RS09040	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ALSL_RS09050	COG0802	atpase or kinase
ALSL_RS09055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ALSL_RS09055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ALSL_RS09070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ALSL_RS09075	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ALSL_RS09080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
ALSL_RS09085	COG2925	Exonuclease
ALSL_RS09105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALSL_RS09105	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ALSL_RS09105	COG1703	isobutyryl-CoA mutase activity
ALSL_RS09125	COG1960	acyl-CoA dehydrogenase activity
ALSL_RS09130	COG0183	Belongs to the thiolase family
ALSL_RS09145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ALSL_RS09165	COG1024	Enoyl-CoA hydratase
ALSL_RS09215	COG4638	Rieske (2fe-2S)
ALSL_RS09220	COG1007	ATP synthesis coupled electron transport
ALSL_RS09235	COG0713	ATP synthesis coupled electron transport
ALSL_RS09240	COG0839	Belongs to the complex I subunit 6 family
ALSL_RS09255	COG1034	ATP synthesis coupled electron transport
ALSL_RS09260	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
ALSL_RS09265	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
ALSL_RS09270	COG0649	NAD binding
ALSL_RS09275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_RS09280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_RS09285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ALSL_RS09290	COG1215	transferase activity, transferring glycosyl groups
ALSL_RS09295	COG0326	Molecular chaperone. Has ATPase activity
ALSL_RS09300	COG0501	Belongs to the peptidase M48B family
ALSL_RS09305	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ALSL_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS09315	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ALSL_RS09320	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ALSL_RS09325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ALSL_RS09330	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ALSL_RS09335	COG0148	phosphopyruvate hydratase activity
ALSL_RS09345	COG2877	3-deoxy-8-phosphooctulonate synthase activity
ALSL_RS09365	COG0662	Cupin 2, conserved barrel domain protein
ALSL_RS09375	COG0531	amino acid
ALSL_RS09380	COG0531	amino acid
ALSL_RS09395	COG0235	Class ii aldolase
ALSL_RS09400	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ALSL_RS09405	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
ALSL_RS09415	COG0140	phosphoribosyl-ATP diphosphatase activity
ALSL_RS09415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ALSL_RS09425	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ALSL_RS09435	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
ALSL_RS09435	COG0131	Imidazoleglycerol-phosphate dehydratase
ALSL_RS09440	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ALSL_RS09445	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ALSL_RS09450	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ALSL_RS09460	COG1663	tetraacyldisaccharide 4'-kinase activity
ALSL_RS09465	COG1132	(ABC) transporter
ALSL_RS09475	COG0811	peptide transport
ALSL_RS09480	COG2333	competence protein COMEC
ALSL_RS09480	COG0658	competence protein
ALSL_RS09490	COG4591	ABC-type transport system involved in lipoprotein release permease component
ALSL_RS09505	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ALSL_RS09515	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
ALSL_RS09520	COG2009	succinate dehydrogenase
ALSL_RS09530	COG0354	folic acid binding
ALSL_RS09590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ALSL_RS09610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_RS09625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
ALSL_RS09640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
ALSL_RS09645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
ALSL_RS09655	COG0617	tRNA 3'-terminal CCA addition
ALSL_RS09665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ALSL_RS09670	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ALSL_RS09690	COG0300	oxidoreductase activity
ALSL_RS09695	COG0149	triose-phosphate isomerase activity
ALSL_RS09700	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALSL_RS09710	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ALSL_RS09720	COG1064	alcohol dehydrogenase
ALSL_RS09730	COG2366	antibiotic biosynthetic process
ALSL_RS09735	COG1024	Enoyl-CoA hydratase
ALSL_RS09735	COG1250	3-hydroxyacyl-CoA dehydrogenase
ALSL_RS09745	COG2900	Belongs to the SlyX family
ALSL_RS09755	COG0545	Peptidyl-prolyl cis-trans isomerase
ALSL_RS09760	COG4651	solute:proton antiporter activity
ALSL_RS09760	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ALSL_RS09800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ALSL_RS09805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ALSL_RS09820	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
ALSL_RS09860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ALSL_RS09865	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
ALSL_RS09870	COG1534	Rna-binding protein
ALSL_RS09890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALSL_RS09920	COG1902	pentaerythritol trinitrate reductase activity
ALSL_RS09925	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALSL_RS09925	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ALSL_RS09940	COG0330	HflC and HflK could
ALSL_RS09945	COG0330	HflC and HflK could
ALSL_RS09950	COG3788	relative of glutathione S-transferase, MAPEG superfamily
ALSL_RS09970	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ALSL_RS09980	COG2010	Cytochrome c
ALSL_RS09990	COG0154	amidase activity
ALSL_RS09995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
ALSL_RS10000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ALSL_RS10005	COG0203	ribosomal protein L17
ALSL_RS10010	COG0202	RNA polymerase activity
ALSL_RS10015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ALSL_RS10020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ALSL_RS10025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ALSL_RS10030	COG0201	protein transport
ALSL_RS10045	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ALSL_RS10050	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ALSL_RS10060	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ALSL_RS10065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ALSL_RS10070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ALSL_RS10075	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ALSL_RS10095	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ALSL_RS10100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ALSL_RS10105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ALSL_RS10110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ALSL_RS10115	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ALSL_RS10120	COG0089	rRNA binding
ALSL_RS10130	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ALSL_RS10135	COG0051	transcription antitermination factor activity, RNA binding
ALSL_RS10140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALSL_RS10150	COG0049	tRNA binding
ALSL_RS10155	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ALSL_RS10160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ALSL_RS10165	COG0085	RNA polymerase activity
ALSL_RS10170	COG0222	ribosome binding
ALSL_RS10175	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ALSL_RS10180	COG0081	regulation of translation
ALSL_RS10185	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ALSL_RS10190	COG0250	Participates in transcription elongation, termination and antitermination
ALSL_RS10195	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ALSL_RS10205	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ALSL_RS10250	COG3387	PFAM Glycoside hydrolase 15-related
ALSL_RS10255	COG3158	transport of potassium into the cell
ALSL_RS10260	COG0632	four-way junction helicase activity
ALSL_RS10280	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ALSL_RS10295	COG4206	TonB-dependent receptor
ALSL_RS10300	COG0542	response to heat
ALSL_RS10305	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
ALSL_RS10315	COG1355	regulation of microtubule-based process
ALSL_RS10320	COG2078	PFAM AMMECR1 domain protein
ALSL_RS10360	COG0531	amino acid
ALSL_RS10420	COG0352	thiamine-phosphate diphosphorylase activity
ALSL_RS10425	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ALSL_RS10440	COG0346	lactoylglutathione lyase activity
ALSL_RS10445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ALSL_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS10455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ALSL_RS10460	COG0563	adenylate kinase activity
ALSL_RS10470	COG0840	transmembrane signaling receptor activity
ALSL_RS10475	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
ALSL_RS10480	COG1505	serine-type exopeptidase activity
ALSL_RS10490	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
ALSL_RS10515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ALSL_RS10520	COG1538	Outer membrane efflux protein
ALSL_RS10525	COG1519	Transferase
ALSL_RS10575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ALSL_RS10595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ALSL_RS10635	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ALSL_RS10660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ALSL_RS10685	COG0494	nUDIX hydrolase
ALSL_RS10720	COG1704	LemA family
ALSL_RS10725	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ALSL_RS10740	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
ALSL_RS10755	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ALSL_RS10765	COG0542	response to heat
ALSL_RS10770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
ALSL_RS10780	COG0482	sulfurtransferase activity
ALSL_RS10785	COG2915	High frequency lysogenization protein hflD homolog
ALSL_RS10800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ALSL_RS10805	COG0667	Aldo Keto reductase
ALSL_RS10810	COG0312	modulator of DNA gyrase
ALSL_RS10845	COG2205	protein histidine kinase activity
ALSL_RS10850	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
ALSL_RS10860	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
ALSL_RS10865	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
ALSL_RS10880	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ALSL_RS10895	COG0495	leucyl-tRNA aminoacylation
ALSL_RS10905	COG3008	intermembrane lipid transfer
ALSL_RS10910	COG2995	paraquat-inducible protein a
ALSL_RS10915	COG2995	paraquat-inducible protein a
ALSL_RS10945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ALSL_RS10950	COG1074	ATP-dependent DNA helicase activity
ALSL_RS10955	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
ALSL_RS10960	COG3161	chorismate lyase activity
ALSL_RS10970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ALSL_RS10985	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ALSL_RS11000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ALSL_RS11025	COG1372	Participates in initiation and elongation during chromosome replication
ALSL_RS11025	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ALSL_RS11030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ALSL_RS11040	COG0546	phosphoglycolate phosphatase activity
ALSL_RS11045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ALSL_RS11055	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS11090	COG0493	'glutamate synthase
ALSL_RS11095	COG0070	glutamate synthase
ALSL_RS11095	COG0069	glutamate synthase activity
ALSL_RS11095	COG0067	glutamate synthase
ALSL_RS11100	COG4942	peptidase
ALSL_RS11105	COG0793	Belongs to the peptidase S41A family
ALSL_RS11120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ALSL_RS11130	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
ALSL_RS11135	COG0596	Alpha beta hydrolase
ALSL_RS11140	COG1668	transmembrane transport
ALSL_RS11145	COG4555	ABC transporter
ALSL_RS11160	COG3121	Chaperone
ALSL_RS11165	COG3188	usher protein
ALSL_RS11180	COG1131	(ABC) transporter
ALSL_RS11185	COG0842	Transport permease protein
ALSL_RS11190	COG0477	Major facilitator Superfamily
ALSL_RS11215	COG1643	Atp-dependent helicase
ALSL_RS11220	COG0793	Belongs to the peptidase S41A family
ALSL_RS11225	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ALSL_RS11230	COG0321	lipoyl(octanoyl) transferase activity
ALSL_RS11235	COG2921	Belongs to the UPF0250 family
ALSL_RS11240	COG1686	Belongs to the peptidase S11 family
ALSL_RS11250	COG2951	lytic endotransglycosylase activity
ALSL_RS11255	COG0772	Belongs to the SEDS family
ALSL_RS11260	COG0768	penicillin binding
ALSL_RS11270	COG1792	Involved in formation and maintenance of cell shape
ALSL_RS11275	COG1077	Cell shape determining protein MreB Mrl
ALSL_RS11280	COG0006	proline dipeptidase activity
ALSL_RS11295	COG1294	oxidase, subunit
ALSL_RS11305	COG0006	proline dipeptidase activity
ALSL_RS11330	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ALSL_RS11345	COG0025	NhaP-type Na H and K H
ALSL_RS11355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ALSL_RS11365	COG0247	lactate metabolic process
ALSL_RS11370	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
ALSL_RS11375	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ALSL_RS11380	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ALSL_RS11395	COG0134	indole-3-glycerol-phosphate synthase activity
ALSL_RS11400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ALSL_RS11410	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
ALSL_RS11425	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ALSL_RS11430	COG1877	trehalose-phosphatase activity
ALSL_RS11435	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
ALSL_RS11445	COG0564	pseudouridine synthase activity
ALSL_RS11455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ALSL_RS11455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ALSL_RS11460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ALSL_RS11485	COG0784	Response regulator, receiver
ALSL_RS11490	COG4251	negative regulation of phosphorylation
ALSL_RS11495	COG0629	single-stranded DNA binding
ALSL_RS11500	COG2814	Major facilitator Superfamily
ALSL_RS11505	COG0142	geranyltranstransferase activity
ALSL_RS11515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_RS11520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ALSL_RS11530	COG2096	Adenosyltransferase
ALSL_RS11540	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
ALSL_RS11545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ALSL_RS11550	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
ALSL_RS11555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ALSL_RS11560	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ALSL_RS11575	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
ALSL_RS11590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ALSL_RS11595	COG1181	Belongs to the D-alanine--D-alanine ligase family
ALSL_RS11615	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ALSL_RS11620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ALSL_RS11635	COG3116	cell division
ALSL_RS11640	COG0275	rRNA processing
ALSL_RS11655	COG0431	NADPH-dependent FMN reductase
ALSL_RS11660	COG1393	Belongs to the ArsC family
ALSL_RS11670	COG0037	tRNA processing
ALSL_RS11685	COG0612	Peptidase, M16
ALSL_RS11690	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ALSL_RS11700	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
ALSL_RS11705	COG0564	pseudouridine synthase activity
ALSL_RS11725	COG0583	DNA-binding transcription factor activity
ALSL_RS11730	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
ALSL_RS11735	COG2224	Isocitrate lyase
ALSL_RS11740	COG0606	chelatase, subunit chli
ALSL_RS11755	COG0588	phosphoglycerate mutase activity
ALSL_RS11760	COG3038	cytochrome b561
ALSL_RS11765	COG0408	coproporphyrinogen oxidase activity
ALSL_RS11790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ALSL_RS11795	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ALSL_RS11805	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ALSL_RS11815	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ALSL_RS11825	COG0356	it plays a direct role in the translocation of protons across the membrane
ALSL_RS11840	COG0730	response to heat
ALSL_RS11845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ALSL_RS11875	COG0625	glutathione transferase activity
ALSL_RS11880	COG0126	phosphoglycerate kinase activity
ALSL_RS11895	COG3588	fructose-bisphosphate aldolase
ALSL_RS11910	COG4786	Flagellar basal body rod
ALSL_RS11915	COG3951	Flagellar rod assembly protein muramidase FlgJ
ALSL_RS11915	COG1705	Flagellar rod assembly protein muramidase FlgJ
ALSL_RS11925	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
ALSL_RS11940	COG1749	Flagellar hook protein flgE
ALSL_RS11945	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ALSL_RS11955	COG1815	bacterial-type flagellum-dependent cell motility
ALSL_RS11990	COG0405	Gamma-glutamyltransferase
ALSL_RS11995	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
ALSL_RS12005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ALSL_RS12010	COG0742	ribosomal rna small subunit methyltransferase
ALSL_RS12015	COG0552	protein localization to endoplasmic reticulum
ALSL_RS12025	COG1194	a g-specific adenine glycosylase
ALSL_RS12030	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
ALSL_RS12055	COG2856	Zn peptidase
ALSL_RS12210	COG3609	addiction module antidote protein, CC2985 family
ALSL_RS12235	COG2856	Zn peptidase
ALSL_RS12520	COG3609	addiction module antidote protein, CC2985 family
ALSL_RS12540	COG1902	pentaerythritol trinitrate reductase activity
ALSL_RS12560	COG0514	ATP-dependent DNA helicase (RecQ)
ALSL_RS12580	COG1566	PFAM secretion protein HlyD family protein
ALSL_RS12600	COG0306	phosphate transporter
ALSL_RS12610	COG1253	flavin adenine dinucleotide binding
ALSL_RS12615	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
ALSL_RS12635	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ALSL_RS12650	COG1560	Kdo2-lipid A biosynthetic process
ALSL_RS12675	COG2353	YceI-like domain
ALSL_RS12690	COG1285	pathogenesis
ALSL_RS12700	COG1368	sulfuric ester hydrolase activity
ALSL_RS12715	COG1566	PFAM secretion protein HlyD family protein
ALSL_RS12735	COG1324	tolerance protein
ALSL_RS12740	COG4232	protein-disulfide reductase activity
ALSL_RS12745	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ALSL_RS12770	COG0625	glutathione transferase activity
ALSL_RS12785	COG0625	glutathione transferase activity
ALSL_RS12795	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS12805	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
ALSL_RS12810	COG2937	Belongs to the GPAT DAPAT family
ALSL_RS12820	COG2226	methyltransferase
ALSL_RS12830	COG0318	PFAM AMP-dependent synthetase and ligase
ALSL_RS12845	COG0457	Tetratricopeptide repeat
ALSL_RS12850	COG2188	Transcriptional regulator
ALSL_RS12855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ALSL_RS12860	COG0363	glucosamine-6-phosphate deaminase activity
ALSL_RS12865	COG0129	dihydroxy-acid dehydratase activity
ALSL_RS12870	COG0800	Aldolase
ALSL_RS12875	COG0084	hydrolase, TatD family'
ALSL_RS12880	COG3227	Zinc metalloprotease (Elastase)
ALSL_RS12890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ALSL_RS12895	COG1459	type II secretion system
ALSL_RS12900	COG2165	general secretion pathway protein
ALSL_RS12910	COG2165	general secretion pathway protein
ALSL_RS12920	COG3156	type II secretion system protein K
ALSL_RS12925	COG3166	PFAM Fimbrial assembly family protein
ALSL_RS12940	COG1450	Type ii and iii secretion system protein
ALSL_RS12945	COG1199	ATP-dependent helicase activity
ALSL_RS12950	COG5001	Diguanylate cyclase
ALSL_RS12950	COG3300	MHYT domain
ALSL_RS12975	COG3273	potassium ion transport
ALSL_RS12975	COG0471	metal ion transport
ALSL_RS12995	COG0181	hydroxymethylbilane synthase activity
ALSL_RS13005	COG3275	phosphorelay sensor kinase activity
ALSL_RS13015	COG0823	Involved in the tonB-independent uptake of proteins
ALSL_RS13015	COG4946	Tricorn protease homolog
ALSL_RS13015	COG1506	peptidase
ALSL_RS13025	COG0640	Transcriptional regulator
ALSL_RS13030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ALSL_RS13030	COG3453	Protein conserved in bacteria
ALSL_RS13060	COG1566	PFAM secretion protein HlyD family protein
ALSL_RS13065	COG2814	Major facilitator Superfamily
ALSL_RS13075	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
ALSL_RS13085	COG1028	Short-chain dehydrogenase reductase Sdr
ALSL_RS13095	COG0673	inositol 2-dehydrogenase activity
ALSL_RS13105	COG0616	signal peptide processing
ALSL_RS13110	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ALSL_RS13120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ALSL_RS13130	COG2205	protein histidine kinase activity
ALSL_RS13140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ALSL_RS13145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ALSL_RS13150	COG2201	protein-glutamate methylesterase activity
ALSL_RS13155	COG2177	Part of the ABC transporter FtsEX involved in
ALSL_RS13160	COG2884	Cell division ATP-binding protein ftsE
ALSL_RS13175	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ALSL_RS13190	COG0339	signal peptide processing
ALSL_RS13200	COG1956	GAF domain-containing protein
ALSL_RS13205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ALSL_RS13240	COG0741	lytic transglycosylase activity
ALSL_RS13250	COG0617	tRNA 3'-terminal CCA addition
ALSL_RS13285	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ALSL_RS13315	COG0395	ABC-type sugar transport system, permease component
ALSL_RS13320	COG1175	transmembrane transport
ALSL_RS13330	COG3664	PFAM glycoside hydrolase family 39
ALSL_RS13350	COG1609	Transcriptional regulator
ALSL_RS13360	COG0357	Ribosomal RNA small subunit methyltransferase G
ALSL_RS13370	COG1475	DNA binding
ALSL_RS13375	COG0463	Glycosyl transferase, family 2
ALSL_RS13380	COG3189	MarR family transcriptional regulator
ALSL_RS13390	COG3039	Transposase
ALSL_RS13410	COG0456	acetyltransferase
ALSL_RS13425	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ALSL_RS13440	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ALSL_RS13460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ALSL_RS13465	COG1869	D-ribose catabolic process
ALSL_RS13470	COG1129	ABC transporter
ALSL_RS13475	COG1172	Belongs to the binding-protein-dependent transport system permease family
ALSL_RS13480	COG1879	ABC-type sugar transport system periplasmic component
ALSL_RS13490	COG4214	carbohydrate transport
ALSL_RS13495	COG1129	ABC transporter
ALSL_RS13500	COG4213	ABC transporter substrate-binding protein
ALSL_RS13505	COG1070	Carbohydrate kinase
ALSL_RS13515	COG2207	Transcriptional regulator
ALSL_RS13515	COG1609	Transcriptional regulator
ALSL_RS13520	COG2017	converts alpha-aldose to the beta-anomer
ALSL_RS13525	COG2376	Dihydroxyacetone kinase
ALSL_RS13530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ALSL_RS13535	COG0706	membrane insertase activity
ALSL_RS13540	COG0594	ribonuclease P activity
ALSL_RS13545	COG0230	Belongs to the bacterial ribosomal protein bL34 family