locus-tag	class	description
BG454_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BG454_RS00030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG454_RS00045	COG0066	3-isopropylmalate dehydratase activity
BG454_RS00055	COG0799	negative regulation of ribosome biogenesis
BG454_RS00060	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BG454_RS00070	COG0583	DNA-binding transcription factor activity
BG454_RS00085	COG0746	molybdenum cofactor guanylyltransferase activity
BG454_RS00090	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BG454_RS00100	COG0542	response to heat
BG454_RS00110	COG0587	DNA-directed DNA polymerase activity
BG454_RS00115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BG454_RS00120	COG1047	Peptidyl-prolyl cis-trans
BG454_RS00130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BG454_RS00145	COG2050	protein possibly involved in aromatic compounds catabolism
BG454_RS00150	COG1024	Enoyl-CoA hydratase
BG454_RS00165	COG1703	isobutyryl-CoA mutase activity
BG454_RS00170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BG454_RS00250	COG0517	IMP dehydrogenase activity
BG454_RS00250	COG1994	Peptidase M50
BG454_RS00310	COG3264	Mechanosensitive ion channel
BG454_RS00310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG454_RS00330	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG454_RS00350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG454_RS00355	COG2181	nitrate reductase activity
BG454_RS00360	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BG454_RS00365	COG1140	nitrate reductase beta subunit
BG454_RS00370	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BG454_RS00395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG454_RS00420	COG1283	sodium-dependent phosphate transmembrane transporter activity
BG454_RS00425	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
BG454_RS00430	COG0395	ABC-type sugar transport system, permease component
BG454_RS00435	COG1175	transmembrane transport
BG454_RS00440	COG1653	transport
BG454_RS00450	COG1349	DNA-binding transcription factor activity
BG454_RS00475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG454_RS00480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG454_RS00485	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BG454_RS00500	COG1733	regulation of RNA biosynthetic process
BG454_RS00505	COG0402	S-adenosylhomocysteine deaminase activity
BG454_RS00530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG454_RS00560	COG0697	spore germination
BG454_RS00570	COG0251	oxidation-reduction process
BG454_RS00580	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS00585	COG0601	transmembrane transport
BG454_RS00630	COG1802	Transcriptional regulator
BG454_RS00635	COG3257	ureidoglycine aminohydrolase activity
BG454_RS00640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BG454_RS00645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS00695	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BG454_RS00795	COG3188	usher protein
BG454_RS00865	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG454_RS00890	COG0582	viral genome integration into host DNA
BG454_RS00965	COG1475	DNA binding
BG454_RS00970	COG1475	DNA binding
BG454_RS01175	COG2319	Wd-40 repeat
BG454_RS01175	COG4249	Peptidase C14 caspase catalytic subunit p20
BG454_RS01235	COG0287	Prephenate dehydrogenase
BG454_RS01240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BG454_RS01250	COG0354	folic acid binding
BG454_RS01255	COG1741	Belongs to the pirin family
BG454_RS01275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG454_RS01280	COG0791	NLP P60 protein
BG454_RS01285	COG1643	Atp-dependent helicase
BG454_RS01295	COG0651	ATP synthesis coupled electron transport
BG454_RS01300	COG0651	ATP synthesis coupled electron transport
BG454_RS01305	COG0651	ATP synthesis coupled electron transport
BG454_RS01320	COG1320	monovalent cation:proton antiporter activity
BG454_RS01350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG454_RS01350	COG0512	Glutamine amidotransferase of anthranilate synthase
BG454_RS01355	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG454_RS01365	COG0725	ABC transporter, periplasmic molybdate-binding protein
BG454_RS01370	COG4149	molybdate abc transporter
BG454_RS01375	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BG454_RS01385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BG454_RS01395	COG2264	protein methyltransferase activity
BG454_RS01425	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BG454_RS01425	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BG454_RS01435	COG2040	homocysteine
BG454_RS01440	COG0584	glycerophosphoryl diester phosphodiesterase
BG454_RS01460	COG1116	anion transmembrane transporter activity
BG454_RS01465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS01470	COG0438	transferase activity, transferring glycosyl groups
BG454_RS01485	COG2244	polysaccharide biosynthetic process
BG454_RS01490	COG1215	transferase activity, transferring glycosyl groups
BG454_RS01495	COG0438	transferase activity, transferring glycosyl groups
BG454_RS01500	COG1215	transferase activity, transferring glycosyl groups
BG454_RS01530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BG454_RS01535	COG2971	BadF BadG BcrA BcrD
BG454_RS01540	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
BG454_RS01550	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BG454_RS01555	COG4143	(ABC) transporter
BG454_RS01565	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
BG454_RS01575	COG1160	GTP binding
BG454_RS01595	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG454_RS01600	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG454_RS01620	COG0688	phosphatidylethanolamine metabolic process
BG454_RS01640	COG3030	protein affecting phage T7 exclusion by the F plasmid
BG454_RS01650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BG454_RS01655	COG0237	dephospho-CoA kinase activity
BG454_RS01660	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG454_RS01665	COG0424	maF-like protein
BG454_RS01670	COG1981	membrane
BG454_RS01675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BG454_RS01685	COG0445	tRNA wobble uridine modification
BG454_RS01705	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG454_RS01710	COG0251	oxidation-reduction process
BG454_RS01715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BG454_RS01725	COG1420	regulation of RNA biosynthetic process
BG454_RS01730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BG454_RS01740	COG0280	phosphate acetyltransferase
BG454_RS01740	COG0281	malic enzyme
BG454_RS01745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG454_RS01750	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG454_RS01765	COG4638	Rieske (2fe-2S)
BG454_RS01770	COG1902	pentaerythritol trinitrate reductase activity
BG454_RS01770	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS01860	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BG454_RS01865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BG454_RS01875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BG454_RS01880	COG1674	ftsk spoiiie
BG454_RS01885	COG1706	bacterial-type flagellum-dependent cell motility
BG454_RS01915	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS01915	COG2030	dehydratase
BG454_RS01925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BG454_RS01930	COG2151	metal-sulfur cluster biosynthetic enzyme
BG454_RS01935	COG3396	Phenylacetate-CoA oxygenase
BG454_RS01940	COG3460	Phenylacetate-CoA oxygenase
BG454_RS01945	COG3396	Phenylacetate-CoA oxygenase
BG454_RS01950	COG0183	Belongs to the thiolase family
BG454_RS01980	COG0489	protein tyrosine kinase activity
BG454_RS01985	COG0254	rRNA binding
BG454_RS01990	COG0335	large ribosomal subunit rRNA binding
BG454_RS01995	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BG454_RS02000	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BG454_RS02010	COG0469	pyruvate kinase activity
BG454_RS02040	COG0129	dihydroxy-acid dehydratase activity
BG454_RS02045	COG4948	Mandelate Racemase Muconate Lactonizing
BG454_RS02065	COG3845	ABC transporter
BG454_RS02070	COG4603	Belongs to the binding-protein-dependent transport system permease family
BG454_RS02075	COG1079	Belongs to the binding-protein-dependent transport system permease family
BG454_RS02085	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BG454_RS02090	COG0408	coproporphyrinogen oxidase activity
BG454_RS02095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BG454_RS02100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BG454_RS02135	COG0156	8-amino-7-oxononanoate synthase activity
BG454_RS02145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BG454_RS02155	COG1522	sequence-specific DNA binding
BG454_RS02165	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BG454_RS02190	COG0330	HflC and HflK could
BG454_RS02195	COG2814	Major facilitator Superfamily
BG454_RS02220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG454_RS02225	COG1177	transmembrane transport
BG454_RS02230	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG454_RS02235	COG3842	ATPase activity
BG454_RS02250	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BG454_RS02255	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS02265	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS02280	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS02285	COG0028	Belongs to the TPP enzyme family
BG454_RS02295	COG3454	Phosphonate metabolism
BG454_RS02300	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BG454_RS02305	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BG454_RS02310	COG4778	phosphonate C-P lyase system protein PhnL
BG454_RS02315	COG4107	phosphonate C-P lyase system protein PhnK
BG454_RS02320	COG3627	carbon phosphorus lyase activity
BG454_RS02325	COG3626	phosphonate metabolism
BG454_RS02330	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
BG454_RS02335	COG3624	Phosphonate C-P lyase system protein PhnG
BG454_RS02340	COG2188	Transcriptional regulator
BG454_RS02345	COG3454	Phosphonate metabolism
BG454_RS02365	COG3639	organic phosphonate transmembrane transporter activity
BG454_RS02370	COG3639	organic phosphonate transmembrane transporter activity
BG454_RS02375	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BG454_RS02380	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BG454_RS02385	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
BG454_RS02400	COG2197	response regulator
BG454_RS02430	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
BG454_RS02435	COG3639	organic phosphonate transmembrane transporter activity
BG454_RS02440	COG3639	organic phosphonate transmembrane transporter activity
BG454_RS02445	COG3181	Tripartite tricarboxylate transporter family receptor
BG454_RS02460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG454_RS02465	COG4948	Mandelate Racemase Muconate Lactonizing
BG454_RS02470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS02480	COG0649	NAD binding
BG454_RS02480	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS02490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BG454_RS02500	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BG454_RS02505	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS02510	COG0839	Belongs to the complex I subunit 6 family
BG454_RS02515	COG0713	ATP synthesis coupled electron transport
BG454_RS02520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BG454_RS02530	COG1007	ATP synthesis coupled electron transport
BG454_RS02555	COG0006	proline dipeptidase activity
BG454_RS02570	COG1879	ABC-type sugar transport system periplasmic component
BG454_RS02575	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS02580	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS02585	COG1129	ABC transporter
BG454_RS02595	COG0625	glutathione transferase activity
BG454_RS02600	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
BG454_RS02610	COG0179	Fumarylacetoacetate (FAA) hydrolase
BG454_RS02640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BG454_RS02670	COG0729	surface antigen
BG454_RS02675	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BG454_RS02680	COG1185	polyribonucleotide nucleotidyltransferase activity
BG454_RS02685	COG0745	RESPONSE REGULATOR receiver
BG454_RS02690	COG1846	Transcriptional regulator
BG454_RS02695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG454_RS02720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BG454_RS02750	COG0473	3-isopropylmalate dehydrogenase activity
BG454_RS02760	COG2877	3-deoxy-8-phosphooctulonate synthase activity
BG454_RS02765	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BG454_RS02790	COG0739	heme binding
BG454_RS02795	COG2833	Protein of unknown function (DUF455)
BG454_RS02800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BG454_RS02805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BG454_RS02810	COG0477	Major facilitator Superfamily
BG454_RS02820	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG454_RS02845	COG1024	Enoyl-CoA hydratase
BG454_RS02845	COG1250	3-hydroxyacyl-CoA dehydrogenase
BG454_RS02850	COG3474	cytochrome
BG454_RS02855	COG0156	8-amino-7-oxononanoate synthase activity
BG454_RS02865	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
BG454_RS02900	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BG454_RS02905	COG1429	ligase activity, forming nitrogen-metal bonds
BG454_RS02910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BG454_RS02935	COG1032	radical SAM domain protein
BG454_RS02940	COG1719	4-vinyl reductase, 4VR
BG454_RS02950	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BG454_RS02955	COG2211	Major facilitator Superfamily
BG454_RS02960	COG0644	oxidoreductase
BG454_RS02965	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
BG454_RS02975	COG1562	ergosterol biosynthetic process
BG454_RS02980	COG1233	COG1233 Phytoene dehydrogenase and related
BG454_RS02990	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BG454_RS02995	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
BG454_RS03005	COG5621	secreted hydrolase
BG454_RS03010	COG1233	COG1233 Phytoene dehydrogenase and related
BG454_RS03015	COG0142	geranyltranstransferase activity
BG454_RS03020	COG0500	methyltransferase
BG454_RS03025	COG1063	alcohol dehydrogenase
BG454_RS03030	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
BG454_RS03035	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BG454_RS03040	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
BG454_RS03075	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG454_RS03080	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG454_RS03080	COG3743	rRNA binding
BG454_RS03100	COG0072	phenylalanine-tRNA ligase activity
BG454_RS03100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BG454_RS03110	COG0148	phosphopyruvate hydratase activity
BG454_RS03150	COG1999	signal sequence binding
BG454_RS03155	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BG454_RS03175	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
BG454_RS03185	COG1686	Belongs to the peptidase S11 family
BG454_RS03190	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BG454_RS03195	COG0004	ammonium transporteR
BG454_RS03200	COG0347	Belongs to the P(II) protein family
BG454_RS03205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG454_RS03215	COG2884	Cell division ATP-binding protein ftsE
BG454_RS03250	COG2205	protein histidine kinase activity
BG454_RS03255	COG0402	S-adenosylhomocysteine deaminase activity
BG454_RS03260	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BG454_RS03260	COG3608	succinylglutamate desuccinylase aspartoacylase
BG454_RS03265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BG454_RS03270	COG2080	2 iron, 2 sulfur cluster binding
BG454_RS03275	COG0583	DNA-binding transcription factor activity
BG454_RS03280	COG3239	Fatty acid desaturase
BG454_RS03285	COG2115	Belongs to the xylose isomerase family
BG454_RS03290	COG1070	Carbohydrate kinase
BG454_RS03300	COG4214	carbohydrate transport
BG454_RS03305	COG4213	ABC transporter substrate-binding protein
BG454_RS03320	COG1858	cytochrome C peroxidase
BG454_RS03325	COG0438	transferase activity, transferring glycosyl groups
BG454_RS03340	COG0454	-acetyltransferase
BG454_RS03345	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS03360	COG0179	Fumarylacetoacetate (FAA) hydrolase
BG454_RS03365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS03370	COG0601	transmembrane transport
BG454_RS03380	COG4608	Belongs to the ABC transporter superfamily
BG454_RS03385	COG0444	Belongs to the ABC transporter superfamily
BG454_RS03390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS03400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS03435	COG2186	Transcriptional regulator
BG454_RS03440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG454_RS03445	COG1321	iron dependent repressor
BG454_RS03445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG454_RS03450	COG1121	(ABC) transporter
BG454_RS03455	COG0803	Belongs to the bacterial solute-binding protein 9 family
BG454_RS03460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BG454_RS03490	COG0484	heat shock protein binding
BG454_RS03505	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG454_RS03555	COG1238	metal cluster binding
BG454_RS03590	COG0789	Transcriptional regulator
BG454_RS03620	COG2217	Heavy metal translocating P-type atpase
BG454_RS03630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BG454_RS03700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BG454_RS03730	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG454_RS03750	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS03760	COG0270	DNA (cytosine-5-)-methyltransferase activity
BG454_RS03925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BG454_RS03935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BG454_RS03940	COG3806	Anti-sigma factor
BG454_RS03945	COG1595	DNA-templated transcription, initiation
BG454_RS03995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BG454_RS04000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG454_RS04005	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BG454_RS04040	COG0564	pseudouridine synthase activity
BG454_RS04055	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG454_RS04055	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG454_RS04070	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BG454_RS04085	COG0612	Peptidase, M16
BG454_RS04090	COG0612	Peptidase, M16
BG454_RS04120	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BG454_RS04125	COG1758	RNA polymerase activity
BG454_RS04130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BG454_RS04140	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BG454_RS04145	COG0736	holo-[acyl-carrier-protein] synthase activity
BG454_RS04155	COG0544	peptidyl-prolyl cis-trans isomerase activity
BG454_RS04165	COG0028	Belongs to the TPP enzyme family
BG454_RS04180	COG0187	DNA topoisomerase II activity
BG454_RS04190	COG0668	transmembrane transport
BG454_RS04200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BG454_RS04205	COG0242	peptide deformylase activity
BG454_RS04210	COG0242	peptide deformylase activity
BG454_RS04215	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BG454_RS04220	COG0435	Glutathione S-transferase
BG454_RS04235	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG454_RS04245	COG1030	water channel activity
BG454_RS04255	COG3180	Ammonia monooxygenase
BG454_RS04265	COG1671	Belongs to the UPF0178 family
BG454_RS04275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BG454_RS04330	COG2010	Cytochrome c
BG454_RS04340	COG0348	domain, Protein
BG454_RS04400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BG454_RS04405	COG0222	ribosome binding
BG454_RS04410	COG0085	RNA polymerase activity
BG454_RS04430	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BG454_RS04435	COG0049	tRNA binding
BG454_RS04440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BG454_RS04445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BG454_RS04450	COG0051	transcription antitermination factor activity, RNA binding
BG454_RS04455	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BG454_RS04460	COG0088	Forms part of the polypeptide exit tunnel
BG454_RS04465	COG0089	rRNA binding
BG454_RS04470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BG454_RS04475	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BG454_RS04480	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BG454_RS04485	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BG454_RS04490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BG454_RS04495	COG0255	Belongs to the universal ribosomal protein uL29 family
BG454_RS04510	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BG454_RS04515	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BG454_RS04520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BG454_RS04525	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BG454_RS04530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BG454_RS04535	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BG454_RS04545	COG1841	ribosomal large subunit assembly
BG454_RS04550	COG0200	Binds to the 23S rRNA
BG454_RS04555	COG0201	protein transport
BG454_RS04560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BG454_RS04565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BG454_RS04570	COG0202	RNA polymerase activity
BG454_RS04575	COG0203	ribosomal protein L17
BG454_RS04580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG454_RS04585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BG454_RS04595	COG0546	phosphoglycolate phosphatase activity
BG454_RS04615	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BG454_RS04620	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BG454_RS04630	COG0706	membrane insertase activity
BG454_RS04635	COG0037	tRNA processing
BG454_RS04640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BG454_RS04645	COG0594	ribonuclease P activity
BG454_RS04650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BG454_RS04660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BG454_RS04665	COG3852	Histidine kinase
BG454_RS04680	COG0556	nucleotide-excision repair
BG454_RS04685	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
BG454_RS04700	COG2135	peptidase activity
BG454_RS04810	COG0582	viral genome integration into host DNA
BG454_RS04830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BG454_RS04835	COG1802	Transcriptional regulator
BG454_RS04840	COG0179	Fumarylacetoacetate (FAA) hydrolase
BG454_RS04845	COG3181	Tripartite tricarboxylate transporter family receptor
BG454_RS04855	COG3119	arylsulfatase activity
BG454_RS04890	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BG454_RS04900	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BG454_RS04905	COG0596	Alpha beta hydrolase
BG454_RS04915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
BG454_RS04925	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BG454_RS04930	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BG454_RS04940	COG0305	Participates in initiation and elongation during chromosome replication
BG454_RS04950	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
BG454_RS04955	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BG454_RS04960	COG1968	undecaprenyl-diphosphatase activity
BG454_RS04975	COG0140	phosphoribosyl-ATP diphosphatase activity
BG454_RS04980	COG2239	Acts as a magnesium transporter
BG454_RS04990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BG454_RS05000	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BG454_RS05005	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS05010	COG3474	cytochrome
BG454_RS05025	COG0737	Belongs to the 5'-nucleotidase family
BG454_RS05030	COG3258	Cytochrome c
BG454_RS05055	COG0785	Cytochrome C biogenesis protein
BG454_RS05070	COG2391	methyltransferase activity
BG454_RS05080	COG0010	Belongs to the arginase family
BG454_RS05095	COG1166	arginine decarboxylase activity
BG454_RS05100	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS05110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG454_RS05120	COG1494	fructose-1,6-bisphosphatase
BG454_RS05125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BG454_RS05165	COG0471	metal ion transport
BG454_RS05165	COG0490	domain, Protein
BG454_RS05205	COG0732	type I restriction modification DNA specificity domain
BG454_RS05210	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BG454_RS05265	COG0798	PFAM Bile acid sodium symporter
BG454_RS05275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BG454_RS05290	COG4149	molybdate abc transporter
BG454_RS05300	COG3842	ATPase activity
BG454_RS05305	COG2201	protein-glutamate methylesterase activity
BG454_RS05335	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
BG454_RS05345	COG0804	urea catabolic process
BG454_RS05350	COG0832	Belongs to the urease beta subunit family
BG454_RS05355	COG0831	urea catabolic process
BG454_RS05360	COG0829	nickel cation binding
BG454_RS05385	COG1960	acyl-CoA dehydrogenase activity
BG454_RS05390	COG1024	Enoyl-CoA hydratase
BG454_RS05435	COG0730	response to heat
BG454_RS05455	COG3181	Tripartite tricarboxylate transporter family receptor
BG454_RS05460	COG0583	DNA-binding transcription factor activity
BG454_RS05475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG454_RS05480	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BG454_RS05490	COG0471	metal ion transport
BG454_RS05490	COG0490	domain, Protein
BG454_RS05505	COG4608	Belongs to the ABC transporter superfamily
BG454_RS05510	COG0444	Belongs to the ABC transporter superfamily
BG454_RS05515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS05570	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS05585	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG454_RS05595	COG0346	lactoylglutathione lyase activity
BG454_RS05600	COG1396	sequence-specific DNA binding
BG454_RS05600	COG3800	Transcriptional regulator
BG454_RS05605	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG454_RS05615	COG0045	succinate-CoA ligase (ADP-forming) activity
BG454_RS05620	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BG454_RS05625	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BG454_RS05630	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BG454_RS05640	COG2205	protein histidine kinase activity
BG454_RS05640	COG0784	Response regulator, receiver
BG454_RS05645	COG1278	Cold shock
BG454_RS05650	COG0697	spore germination
BG454_RS05655	COG3237	CsbD-like
BG454_RS05660	COG0628	permease
BG454_RS05665	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BG454_RS05680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BG454_RS05685	COG2010	Cytochrome c
BG454_RS05685	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BG454_RS05705	COG2205	protein histidine kinase activity
BG454_RS05705	COG0784	Response regulator, receiver
BG454_RS05735	COG2943	transferase activity, transferring hexosyl groups
BG454_RS05755	COG1017	nitric oxide dioxygenase activity
BG454_RS05755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BG454_RS05780	COG0784	Response regulator, receiver
BG454_RS05790	COG0071	Belongs to the small heat shock protein (HSP20) family
BG454_RS05805	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BG454_RS05810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BG454_RS05815	COG0322	excinuclease ABC activity
BG454_RS05830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BG454_RS05830	COG0616	signal peptide processing
BG454_RS05840	COG3474	cytochrome
BG454_RS05845	COG0351	phosphomethylpyrimidine kinase
BG454_RS05860	COG2022	thiamine diphosphate biosynthetic process
BG454_RS05870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG454_RS05875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG454_RS05880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BG454_RS05885	COG1116	anion transmembrane transporter activity
BG454_RS05890	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS05895	COG0513	Belongs to the DEAD box helicase family
BG454_RS05900	COG3243	poly(R)-hydroxyalkanoic acid synthase
BG454_RS05910	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS05910	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS05915	COG4311	Sarcosine oxidase, delta subunit
BG454_RS05920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS05925	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BG454_RS05930	COG0303	'Molybdopterin
BG454_RS05935	COG0315	cyclic pyranopterin monophosphate synthase activity
BG454_RS05945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BG454_RS05965	COG3034	peptidoglycan biosynthetic process
BG454_RS05985	COG1132	(ABC) transporter
BG454_RS05990	COG0617	tRNA 3'-terminal CCA addition
BG454_RS06015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BG454_RS06025	COG0733	neurotransmitter:sodium symporter activity
BG454_RS06030	COG0137	argininosuccinate synthase activity
BG454_RS06035	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
BG454_RS06045	COG0793	Belongs to the peptidase S41A family
BG454_RS06050	COG1051	belongs to the nudix hydrolase family
BG454_RS06060	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
BG454_RS06065	COG0181	hydroxymethylbilane synthase activity
BG454_RS06070	COG3106	COG3106 Predicted ATPase
BG454_RS06075	COG3768	UPF0283 membrane protein
BG454_RS06090	COG1546	Belongs to the CinA family
BG454_RS06090	COG1058	Belongs to the CinA family
BG454_RS06100	COG0431	NADPH-dependent FMN reductase
BG454_RS06105	COG0028	Belongs to the TPP enzyme family
BG454_RS06110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BG454_RS06115	COG0742	ribosomal rna small subunit methyltransferase
BG454_RS06125	COG0678	peroxiredoxin activity
BG454_RS06135	COG2154	pterin-4-alpha-carbinolamine dehydratase
BG454_RS06145	COG2423	ornithine cyclodeaminase activity
BG454_RS06150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BG454_RS06155	COG0679	Auxin Efflux Carrier
BG454_RS06170	COG0662	Cupin 2, conserved barrel domain protein
BG454_RS06175	COG0504	CTP synthase activity
BG454_RS06185	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BG454_RS06200	COG2962	Rard protein
BG454_RS06210	COG2610	gluconate transmembrane transporter activity
BG454_RS06220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG454_RS06250	COG4695	Portal protein
BG454_RS06330	COG0488	(ABC) transporter
BG454_RS06410	COG1487	ribonuclease activity
BG454_RS06415	COG1002	Type II restriction enzyme, methylase subunits
BG454_RS06430	COG1061	Type III restriction enzyme res subunit
BG454_RS06435	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BG454_RS06445	COG1401	restriction endodeoxyribonuclease activity
BG454_RS06555	COG1030	water channel activity
BG454_RS06630	COG1475	DNA binding
BG454_RS06635	COG1475	DNA binding
BG454_RS06735	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS06755	COG3604	Transcriptional regulator
BG454_RS06760	COG1116	anion transmembrane transporter activity
BG454_RS06760	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG454_RS06765	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS06770	COG1116	anion transmembrane transporter activity
BG454_RS06770	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG454_RS06775	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
BG454_RS06785	COG1741	Belongs to the pirin family
BG454_RS06790	COG0346	lactoylglutathione lyase activity
BG454_RS06800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BG454_RS06800	COG0475	glutathione-regulated potassium exporter activity
BG454_RS06805	COG0346	lactoylglutathione lyase activity
BG454_RS06810	COG0583	DNA-binding transcription factor activity
BG454_RS06880	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BG454_RS06890	COG0028	Belongs to the TPP enzyme family
BG454_RS06895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BG454_RS06900	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG454_RS06920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS06925	COG1414	Transcriptional regulator
BG454_RS06940	COG1858	cytochrome C peroxidase
BG454_RS06950	COG3901	Regulator of nitric oxide reductase transcription
BG454_RS06950	COG0348	domain, Protein
BG454_RS06960	COG1695	Transcriptional regulator
BG454_RS07040	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG454_RS07045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG454_RS07050	COG4558	Periplasmic binding protein
BG454_RS07055	COG3720	iron ion transport
BG454_RS07065	COG0811	peptide transport
BG454_RS07085	COG4206	TonB-dependent receptor
BG454_RS07100	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
BG454_RS07115	COG0848	biopolymer transport protein
BG454_RS07140	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BG454_RS07165	COG1091	dTDP-4-dehydrorhamnose reductase activity
BG454_RS07170	COG1088	dTDP-glucose 4,6-dehydratase activity
BG454_RS07175	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BG454_RS07180	COG0840	transmembrane signaling receptor activity
BG454_RS07185	COG0840	transmembrane signaling receptor activity
BG454_RS07200	COG2201	protein-glutamate methylesterase activity
BG454_RS07210	COG0745	RESPONSE REGULATOR receiver
BG454_RS07225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BG454_RS07230	COG0745	RESPONSE REGULATOR receiver
BG454_RS07240	COG4175	Glycine betaine
BG454_RS07240	COG0517	IMP dehydrogenase activity
BG454_RS07245	COG4176	ABC-type proline glycine betaine transport system permease component
BG454_RS07270	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS07275	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG454_RS07280	COG0583	DNA-binding transcription factor activity
BG454_RS07290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
BG454_RS07295	COG1024	Enoyl-CoA hydratase
BG454_RS07300	COG0574	Belongs to the PEP-utilizing enzyme family
BG454_RS07300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG454_RS07310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG454_RS07325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BG454_RS07330	COG0463	Glycosyl transferase, family 2
BG454_RS07335	COG2244	polysaccharide biosynthetic process
BG454_RS07350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS07355	COG1522	sequence-specific DNA binding
BG454_RS07390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BG454_RS07395	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
BG454_RS07405	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
BG454_RS07460	COG1024	Enoyl-CoA hydratase
BG454_RS07470	COG1960	acyl-CoA dehydrogenase activity
BG454_RS07475	COG0596	Alpha beta hydrolase
BG454_RS07480	COG0583	DNA-binding transcription factor activity
BG454_RS07490	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
BG454_RS07500	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BG454_RS07510	COG3485	protocatechuate 3,4-dioxygenase
BG454_RS07515	COG3485	protocatechuate 3,4-dioxygenase
BG454_RS07520	COG3246	L-lysine catabolic process to acetate
BG454_RS07525	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG454_RS07550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG454_RS07555	COG2268	Band 7 protein
BG454_RS07565	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS07580	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS07605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BG454_RS07610	COG0583	DNA-binding transcription factor activity
BG454_RS07650	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS07675	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS07680	COG0154	amidase activity
BG454_RS07695	COG1737	Transcriptional regulator
BG454_RS07700	COG2204	response regulator
BG454_RS07700	COG5564	TIM-barrel signal transduction protein
BG454_RS07740	COG5564	TIM-barrel signal transduction protein
BG454_RS07755	COG0673	inositol 2-dehydrogenase activity
BG454_RS07770	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BG454_RS07770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS07805	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BG454_RS07815	COG0826	peptidase U32
BG454_RS07820	COG0826	peptidase U32
BG454_RS07835	COG1522	sequence-specific DNA binding
BG454_RS07860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG454_RS07870	COG3257	ureidoglycine aminohydrolase activity
BG454_RS07875	COG2133	pyrroloquinoline quinone binding
BG454_RS07880	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BG454_RS07890	COG0228	four-way junction DNA binding
BG454_RS07895	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BG454_RS07910	COG1192	Involved in chromosome partitioning
BG454_RS07925	COG2308	Evidence 4 Homologs of previously reported genes of
BG454_RS07955	COG0356	it plays a direct role in the translocation of protons across the membrane
BG454_RS07960	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG454_RS07965	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG454_RS07970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BG454_RS07980	COG2885	chlorophyll binding
BG454_RS07985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BG454_RS07995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BG454_RS08005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BG454_RS08010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BG454_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS08040	COG0175	sulfate reduction
BG454_RS08075	COG0714	Associated with various cellular activities
BG454_RS08090	COG0840	transmembrane signaling receptor activity
BG454_RS08105	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BG454_RS08125	COG0626	cystathionine gamma-synthase activity
BG454_RS08130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG454_RS08145	COG0488	(ABC) transporter
BG454_RS08155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BG454_RS08160	COG3002	Belongs to the UPF0753 family
BG454_RS08170	COG5443	negative regulation of bacterial-type flagellum assembly
BG454_RS08180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BG454_RS08200	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BG454_RS08220	COG1278	Cold shock
BG454_RS08230	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
BG454_RS08235	COG1320	monovalent cation:proton antiporter activity
BG454_RS08240	COG2212	antiporter activity
BG454_RS08245	COG1863	multisubunit Na H antiporter MnhE subunit
BG454_RS08250	COG0651	ATP synthesis coupled electron transport
BG454_RS08255	COG1006	Multisubunit Na H antiporter MnhC subunit
BG454_RS08260	COG2111	Na H antiporter
BG454_RS08265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BG454_RS08265	COG2111	Na H antiporter
BG454_RS08290	COG2096	Adenosyltransferase
BG454_RS08300	COG0300	oxidoreductase activity
BG454_RS08305	COG2204	response regulator
BG454_RS08320	COG0281	malic enzyme
BG454_RS08320	COG0280	phosphate acetyltransferase
BG454_RS08325	COG0295	cytidine deaminase activity
BG454_RS08330	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
BG454_RS08335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
BG454_RS08340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BG454_RS08350	COG0483	inositol monophosphate 1-phosphatase activity
BG454_RS08360	COG0583	DNA-binding transcription factor activity
BG454_RS08365	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG454_RS08375	COG1469	GTP cyclohydrolase I activity
BG454_RS08380	COG1105	Belongs to the carbohydrate kinase PfkB family
BG454_RS08385	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG454_RS08390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BG454_RS08390	COG0519	Catalyzes the synthesis of GMP from XMP
BG454_RS08400	COG0752	glycyl-tRNA synthetase alpha subunit
BG454_RS08415	COG0574	Belongs to the PEP-utilizing enzyme family
BG454_RS08415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BG454_RS08420	COG3773	Cell wall hydrolase
BG454_RS08420	COG3409	Peptidoglycan-binding domain 1 protein
BG454_RS08425	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BG454_RS08435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG454_RS08445	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
BG454_RS08455	COG2351	hydroxyisourate hydrolase activity
BG454_RS08470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BG454_RS08475	COG0745	RESPONSE REGULATOR receiver
BG454_RS08480	COG2205	protein histidine kinase activity
BG454_RS08485	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
BG454_RS08490	COG1660	Displays ATPase and GTPase activities
BG454_RS08515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BG454_RS08550	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BG454_RS08555	COG2267	carboxylic ester hydrolase activity
BG454_RS08600	COG0427	acetyl-CoA hydrolase
BG454_RS08605	COG1250	3-hydroxyacyl-CoA dehydrogenase
BG454_RS08605	COG1024	Enoyl-CoA hydratase
BG454_RS08620	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG454_RS08645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BG454_RS08655	COG0330	HflC and HflK could
BG454_RS08660	COG0330	HflC and HflK could
BG454_RS08670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BG454_RS08675	COG2010	Cytochrome c
BG454_RS08680	COG1760	l-serine dehydratase
BG454_RS08695	COG0009	L-threonylcarbamoyladenylate synthase
BG454_RS08700	COG1960	acyl-CoA dehydrogenase activity
BG454_RS08705	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG454_RS08720	COG0564	pseudouridine synthase activity
BG454_RS08725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BG454_RS08730	COG3383	formate dehydrogenase (NAD+) activity
BG454_RS08735	COG0513	Belongs to the DEAD box helicase family
BG454_RS08745	COG1278	Cold shock
BG454_RS08750	COG1393	Belongs to the ArsC family
BG454_RS08755	COG1435	thymidine kinase activity
BG454_RS08780	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BG454_RS08785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BG454_RS08790	COG1329	Transcriptional regulator
BG454_RS08795	COG0217	transcriptional regulatory protein
BG454_RS08810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BG454_RS08810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BG454_RS08820	COG1024	Enoyl-CoA hydratase
BG454_RS08825	COG4175	Glycine betaine
BG454_RS08830	COG4176	ABC-type proline glycine betaine transport system permease component
BG454_RS08840	COG1309	transcriptional regulator
BG454_RS08850	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BG454_RS08855	COG1525	nuclease
BG454_RS08860	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BG454_RS08870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BG454_RS08880	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG454_RS08885	COG3842	ATPase activity
BG454_RS08890	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG454_RS08895	COG1177	transmembrane transport
BG454_RS08915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG454_RS08920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BG454_RS08925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG454_RS08955	COG1181	Belongs to the D-alanine--D-alanine ligase family
BG454_RS08960	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BG454_RS08965	COG0849	cell division
BG454_RS08980	COG3474	cytochrome
BG454_RS08985	COG0842	Transport permease protein
BG454_RS09000	COG0497	DNA recombination
BG454_RS09005	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG454_RS09025	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BG454_RS09035	COG0439	Biotin carboxylase
BG454_RS09050	COG0745	RESPONSE REGULATOR receiver
BG454_RS09060	COG5002	protein histidine kinase activity
BG454_RS09065	COG0493	'glutamate synthase
BG454_RS09075	COG1309	transcriptional regulator
BG454_RS09095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS09100	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS09105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG454_RS09110	COG0308	aminopeptidase N
BG454_RS09115	COG2340	Cysteine-rich secretory protein family
BG454_RS09125	COG0154	amidase activity
BG454_RS09135	COG3023	N-Acetylmuramoyl-L-alanine amidase
BG454_RS09150	COG0321	lipoyl(octanoyl) transferase activity
BG454_RS09165	COG3842	ATPase activity
BG454_RS09175	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG454_RS09180	COG1177	transmembrane transport
BG454_RS09185	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BG454_RS09205	COG1720	tRNA m6t6A37 methyltransferase activity
BG454_RS09210	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BG454_RS09215	COG0248	Ppx GppA phosphatase
BG454_RS09225	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BG454_RS09235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BG454_RS09240	COG0740	serine-type endopeptidase activity
BG454_RS09255	COG0129	dihydroxy-acid dehydratase activity
BG454_RS09260	COG0501	Belongs to the peptidase M48B family
BG454_RS09275	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BG454_RS09280	COG1127	ABC transporter
BG454_RS09305	COG5425	PFAM Usg family protein
BG454_RS09310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG454_RS09335	COG0006	proline dipeptidase activity
BG454_RS09340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG454_RS09350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BG454_RS09365	COG1558	bacterial-type flagellum-dependent cell motility
BG454_RS09370	COG1677	Flagellar hook-basal body complex protein FliE
BG454_RS09375	COG1987	bacterial-type flagellum assembly
BG454_RS09380	COG4786	Flagellar basal body rod
BG454_RS09385	COG4786	Flagellar basal body rod
BG454_RS09395	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BG454_RS09405	COG2309	aminopeptidase activity
BG454_RS09425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BG454_RS09455	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
BG454_RS09465	COG0596	Alpha beta hydrolase
BG454_RS09470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BG454_RS09490	COG2084	Dehydrogenase
BG454_RS09495	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BG454_RS09520	COG1802	Transcriptional regulator
BG454_RS09530	COG1610	YqeY-like protein
BG454_RS09535	COG0505	Belongs to the CarA family
BG454_RS09550	COG0039	L-malate dehydrogenase activity
BG454_RS09555	COG0045	succinate-CoA ligase (ADP-forming) activity
BG454_RS09575	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG454_RS09605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BG454_RS09610	COG0358	DNA primase activity
BG454_RS09615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG454_RS09625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BG454_RS09630	COG1309	transcriptional regulator
BG454_RS09645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
BG454_RS09650	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS09660	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BG454_RS09665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BG454_RS09665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BG454_RS09670	COG0590	tRNA wobble adenosine to inosine editing
BG454_RS09680	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BG454_RS09690	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BG454_RS09700	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BG454_RS09710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG454_RS09725	COG3842	ATPase activity
BG454_RS09745	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS09750	COG1064	alcohol dehydrogenase
BG454_RS09755	COG0047	phosphoribosylformylglycinamidine synthase activity
BG454_RS09765	COG2204	response regulator
BG454_RS09775	COG1530	ribonuclease E activity
BG454_RS09780	COG0785	Cytochrome C biogenesis protein
BG454_RS09790	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BG454_RS09795	COG1132	(ABC) transporter
BG454_RS09800	COG1216	Glycosyl transferase, family 2
BG454_RS09810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BG454_RS09810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BG454_RS09820	COG0277	FAD linked oxidase domain protein
BG454_RS09825	COG0277	FAD linked oxidase domain protein
BG454_RS09830	COG0247	lactate metabolic process
BG454_RS09845	COG1496	oxidoreductase activity
BG454_RS09855	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BG454_RS09870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BG454_RS09880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BG454_RS09885	COG1132	(ABC) transporter
BG454_RS09915	COG0250	Participates in transcription elongation, termination and antitermination
BG454_RS09920	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BG454_RS09925	COG0081	regulation of translation
BG454_RS09930	COG0314	molybdopterin synthase activity
BG454_RS09940	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG454_RS09945	COG2816	NAD+ diphosphatase activity
BG454_RS09955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS09960	COG0509	glycine decarboxylation via glycine cleavage system
BG454_RS09965	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BG454_RS09965	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BG454_RS09970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BG454_RS09980	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BG454_RS09985	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BG454_RS09990	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BG454_RS10000	COG0444	Belongs to the ABC transporter superfamily
BG454_RS10005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS10010	COG0601	transmembrane transport
BG454_RS10015	COG0747	negative chemotaxis
BG454_RS10030	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
BG454_RS10035	COG1917	Cupin 2, conserved barrel domain protein
BG454_RS10040	COG0527	aspartate kinase activity
BG454_RS10045	COG0539	negative regulation of cytoplasmic translation
BG454_RS10050	COG0776	regulation of translation
BG454_RS10060	COG0135	phosphoribosylanthranilate isomerase activity
BG454_RS10065	COG1959	2 iron, 2 sulfur cluster binding
BG454_RS10070	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS10085	COG0215	cysteine-tRNA ligase activity
BG454_RS10090	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BG454_RS10105	COG1862	Preprotein translocase
BG454_RS10110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG454_RS10115	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BG454_RS10120	COG3737	Protein of unknown function (DUF498/DUF598)
BG454_RS10125	COG4133	protoheme IX ABC transporter activity
BG454_RS10130	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG454_RS10135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BG454_RS10145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BG454_RS10215	COG2124	cytochrome p450
BG454_RS10225	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BG454_RS10235	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BG454_RS10245	COG0248	Ppx GppA phosphatase
BG454_RS10250	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BG454_RS10275	COG4166	transmembrane transport
BG454_RS10280	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS10295	COG2313	pseudouridylate synthase activity
BG454_RS10315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BG454_RS10325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BG454_RS10335	COG0101	tRNA pseudouridine synthase activity
BG454_RS10350	COG2326	polyphosphate kinase activity
BG454_RS10365	COG1609	Transcriptional regulator
BG454_RS10370	COG0525	valine-tRNA ligase activity
BG454_RS10395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
BG454_RS10410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BG454_RS10415	COG1217	gtp-binding protein TYPA
BG454_RS10435	COG2076	Multidrug Resistance protein
BG454_RS10445	COG2945	thiolester hydrolase activity
BG454_RS10450	COG1959	2 iron, 2 sulfur cluster binding
BG454_RS10460	COG0719	Fe-S assembly protein
BG454_RS10465	COG0396	ATPase activity
BG454_RS10470	COG0719	Fe-S assembly protein
BG454_RS10485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG454_RS10510	COG1136	(ABC) transporter
BG454_RS10530	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BG454_RS10535	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BG454_RS10555	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BG454_RS10555	COG3264	Mechanosensitive ion channel
BG454_RS10575	COG0784	Response regulator, receiver
BG454_RS10575	COG4191	Histidine kinase
BG454_RS10590	COG0559	Belongs to the binding-protein-dependent transport system permease family
BG454_RS10595	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS10620	COG0284	orotidine-5'-phosphate decarboxylase activity
BG454_RS10660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BG454_RS10665	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BG454_RS10670	COG1137	ATPase activity
BG454_RS10690	COG1272	protein, Hemolysin III
BG454_RS10695	COG0584	glycerophosphoryl diester phosphodiesterase
BG454_RS10705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
BG454_RS10730	COG0625	glutathione transferase activity
BG454_RS10735	COG2917	probably involved in intracellular septation
BG454_RS10745	COG2873	o-acetylhomoserine
BG454_RS10750	COG0457	Tetratricopeptide repeat
BG454_RS10755	COG2951	lytic endotransglycosylase activity
BG454_RS10760	COG2951	lytic endotransglycosylase activity
BG454_RS10770	COG0523	cobalamin synthesis protein
BG454_RS10775	COG1830	Aldolase
BG454_RS10835	COG0629	single-stranded DNA binding
BG454_RS10840	COG0741	lytic transglycosylase activity
BG454_RS10845	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BG454_RS10850	COG0415	Belongs to the DNA photolyase family
BG454_RS10855	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BG454_RS10865	COG0494	nUDIX hydrolase
BG454_RS10905	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BG454_RS10905	COG0519	Catalyzes the synthesis of GMP from XMP
BG454_RS10910	COG2379	hydroxypyruvate reductase
BG454_RS10925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BG454_RS10930	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BG454_RS10940	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BG454_RS10945	COG0418	dihydroorotase activity
BG454_RS10960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BG454_RS10965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BG454_RS10970	COG0482	sulfurtransferase activity
BG454_RS10985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BG454_RS10990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BG454_RS10995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BG454_RS11000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG454_RS11005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BG454_RS11015	COG0033	Phosphoglucomutase
BG454_RS11020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BG454_RS11030	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BG454_RS11035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BG454_RS11070	COG0133	tryptophan synthase activity
BG454_RS11155	COG0415	Belongs to the DNA photolyase family
BG454_RS11160	COG0183	Belongs to the thiolase family
BG454_RS11170	COG0557	exoribonuclease II activity
BG454_RS11180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BG454_RS11195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG454_RS11200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG454_RS11215	COG2358	TRAP transporter, solute receptor (TAXI family
BG454_RS11220	COG1473	amidohydrolase
BG454_RS11225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BG454_RS11230	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BG454_RS11260	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BG454_RS11270	COG1007	ATP synthesis coupled electron transport
BG454_RS11285	COG0713	ATP synthesis coupled electron transport
BG454_RS11295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS11300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BG454_RS11340	COG0649	NAD binding
BG454_RS11345	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS11350	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BG454_RS11360	COG1024	Enoyl-CoA hydratase
BG454_RS11360	COG1250	3-hydroxyacyl-CoA dehydrogenase
BG454_RS11375	COG4770	biotin carboxylase activity
BG454_RS11380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BG454_RS11390	COG1960	acyl-CoA dehydrogenase activity
BG454_RS11395	COG1957	nucleoside hydrolase
BG454_RS11405	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BG454_RS11415	COG0546	phosphoglycolate phosphatase activity
BG454_RS11440	COG0052	Belongs to the universal ribosomal protein uS2 family
BG454_RS11445	COG0813	purine-nucleoside phosphorylase activity
BG454_RS11450	COG0131	Imidazoleglycerol-phosphate dehydratase
BG454_RS11455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BG454_RS11460	COG1187	pseudouridine synthase activity
BG454_RS11470	COG3853	Toxic anion resistance protein (TelA)
BG454_RS11490	COG1490	D-aminoacyl-tRNA deacylase activity
BG454_RS11500	COG0667	Aldo Keto reductase
BG454_RS11515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG454_RS11520	COG2183	response to ionizing radiation
BG454_RS11525	COG0442	prolyl-tRNA aminoacylation
BG454_RS11540	COG0483	inositol monophosphate 1-phosphatase activity
BG454_RS11545	COG1396	sequence-specific DNA binding
BG454_RS11550	COG0604	alcohol dehydrogenase
BG454_RS11555	COG0670	Belongs to the BI1 family
BG454_RS11570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BG454_RS11575	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BG454_RS11590	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BG454_RS11595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BG454_RS11610	COG0180	Tryptophanyl-tRNA synthetase
BG454_RS11625	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
BG454_RS11635	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BG454_RS11640	COG0792	nuclease activity
BG454_RS11645	COG0189	ligase activity
BG454_RS11655	COG0606	chelatase, subunit chli
BG454_RS11670	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BG454_RS11680	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BG454_RS11685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BG454_RS11690	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BG454_RS11700	COG0646	methionine synthase
BG454_RS11700	COG1410	methionine synthase
BG454_RS11705	COG5012	cobalamin binding
BG454_RS11715	COG1522	sequence-specific DNA binding
BG454_RS11730	COG0010	Belongs to the arginase family
BG454_RS11735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS11745	COG1802	Transcriptional regulator
BG454_RS11750	COG1960	acyl-CoA dehydrogenase activity
BG454_RS11765	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BG454_RS11775	COG1268	BioY protein
BG454_RS11780	COG0360	Binds together with S18 to 16S ribosomal RNA
BG454_RS11785	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BG454_RS11790	COG0359	binds to the 23S rRNA
BG454_RS11810	COG5328	Belongs to the UPF0262 family
BG454_RS11830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BG454_RS11830	COG3153	acetyltransferase
BG454_RS11835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BG454_RS11840	COG0424	maF-like protein
BG454_RS11850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BG454_RS11860	COG0105	UTP biosynthetic process
BG454_RS11865	COG2937	Belongs to the GPAT DAPAT family
BG454_RS11870	COG0604	alcohol dehydrogenase
BG454_RS11895	COG0730	response to heat
BG454_RS11900	COG1079	Belongs to the binding-protein-dependent transport system permease family
BG454_RS11905	COG4603	Belongs to the binding-protein-dependent transport system permease family
BG454_RS11910	COG3845	ABC transporter
BG454_RS11915	COG1744	ABC transporter substrate-binding protein PnrA-like
BG454_RS11925	COG1214	PFAM Peptidase M22, glycoprotease
BG454_RS11930	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BG454_RS11950	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BG454_RS11955	COG0571	ribonuclease III activity
BG454_RS11960	COG0681	Belongs to the peptidase S26 family
BG454_RS11965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BG454_RS11985	COG0768	penicillin binding
BG454_RS11990	COG0772	Belongs to the SEDS family
BG454_RS12015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
BG454_RS12030	COG4221	oxidoreductase activity
BG454_RS12035	COG0824	Thioesterase
BG454_RS12045	COG0848	biopolymer transport protein
BG454_RS12055	COG0823	Involved in the tonB-independent uptake of proteins
BG454_RS12060	COG2885	chlorophyll binding
BG454_RS12070	COG0037	tRNA processing
BG454_RS12075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG454_RS12085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BG454_RS12115	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BG454_RS12125	COG0232	Belongs to the dGTPase family. Type 2 subfamily
BG454_RS12130	COG0316	Belongs to the HesB IscA family
BG454_RS12140	COG1132	(ABC) transporter
BG454_RS12145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS12150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BG454_RS12155	COG1121	(ABC) transporter
BG454_RS12170	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BG454_RS12180	COG0625	glutathione transferase activity
BG454_RS12185	COG0328	RNA-DNA hybrid ribonuclease activity
BG454_RS12190	COG2860	membrane
BG454_RS12200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BG454_RS12225	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BG454_RS12245	COG2897	thiosulfate sulfurtransferase activity
BG454_RS12250	COG2391	methyltransferase activity
BG454_RS12260	COG0166	Belongs to the GPI family
BG454_RS12270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BG454_RS12300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BG454_RS12305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BG454_RS12310	COG2350	Protein conserved in bacteria
BG454_RS12320	COG4172	Belongs to the ABC transporter superfamily
BG454_RS12325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS12330	COG0601	transmembrane transport
BG454_RS12345	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BG454_RS12350	COG4235	cytochrome complex assembly
BG454_RS12355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS12370	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BG454_RS12370	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS12385	COG3842	ATPase activity
BG454_RS12390	COG0395	ABC-type sugar transport system, permease component
BG454_RS12395	COG1175	transmembrane transport
BG454_RS12410	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS12415	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
BG454_RS12425	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
BG454_RS12430	COG2814	Major facilitator Superfamily
BG454_RS12435	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS12440	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BG454_RS12445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
BG454_RS12450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BG454_RS12455	COG0433	COG0433 Predicted ATPase
BG454_RS12485	COG1278	Cold shock
BG454_RS12490	COG0259	pyridoxamine-phosphate oxidase activity
BG454_RS12495	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BG454_RS12515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BG454_RS12540	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BG454_RS12540	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BG454_RS12555	COG4770	biotin carboxylase activity
BG454_RS12570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BG454_RS12580	COG1396	sequence-specific DNA binding
BG454_RS12580	COG3800	Transcriptional regulator
BG454_RS12595	COG0402	S-adenosylhomocysteine deaminase activity
BG454_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS12610	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
BG454_RS12620	COG0589	response to stress
BG454_RS12625	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BG454_RS12630	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG454_RS12630	COG0022	dehydrogenase e1 component
BG454_RS12635	COG0508	dehydrogenase complex catalyzes the overall conversion of
BG454_RS12660	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BG454_RS12665	COG0416	fatty acid biosynthetic process
BG454_RS12670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BG454_RS12675	COG0776	regulation of translation
BG454_RS12695	COG0717	Belongs to the dCTP deaminase family
BG454_RS12700	COG2095	MarC family integral membrane protein
BG454_RS12710	COG2890	protein-(glutamine-N5) methyltransferase activity
BG454_RS12715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BG454_RS12720	COG4536	flavin adenine dinucleotide binding
BG454_RS12725	COG1131	(ABC) transporter
BG454_RS12735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG454_RS12735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BG454_RS12740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BG454_RS12750	COG1215	transferase activity, transferring glycosyl groups
BG454_RS12755	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BG454_RS12760	COG0006	proline dipeptidase activity
BG454_RS12770	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BG454_RS12775	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BG454_RS12785	COG4974	Belongs to the 'phage' integrase family
BG454_RS12790	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG454_RS12795	COG3494	Protein of unknown function (DUF1009)
BG454_RS12800	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BG454_RS12805	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG454_RS12815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BG454_RS12820	COG0750	zinc metalloprotease
BG454_RS12835	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BG454_RS12840	COG0233	cytoplasmic translational termination
BG454_RS12880	COG1686	Belongs to the peptidase S11 family
BG454_RS12885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BG454_RS12895	COG0084	hydrolase, TatD family'
BG454_RS12900	COG0321	lipoyl(octanoyl) transferase activity
BG454_RS12900	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
BG454_RS12920	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BG454_RS12925	COG2166	iron-sulfur cluster assembly
BG454_RS12940	COG0018	arginyl-trna synthetase
BG454_RS12950	COG1472	Belongs to the glycosyl hydrolase 3 family
BG454_RS12995	COG3485	protocatechuate 3,4-dioxygenase
BG454_RS13020	COG1137	ATPase activity
BG454_RS13045	COG3485	protocatechuate 3,4-dioxygenase
BG454_RS13050	COG0583	DNA-binding transcription factor activity
BG454_RS13055	COG0490	domain, Protein
BG454_RS13055	COG0471	metal ion transport
BG454_RS13065	COG1136	(ABC) transporter
BG454_RS13065	COG0577	efflux transmembrane transporter activity
BG454_RS13080	COG4134	Bacterial extracellular solute-binding protein
BG454_RS13085	COG4135	transport system, permease component
BG454_RS13090	COG4136	ATPase activity
BG454_RS13095	COG2358	TRAP transporter, solute receptor (TAXI family
BG454_RS13115	COG1238	metal cluster binding
BG454_RS13125	COG0805	protein transport
BG454_RS13135	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BG454_RS13140	COG3706	GGDEF domain
BG454_RS13145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BG454_RS13150	COG1923	regulation of RNA biosynthetic process
BG454_RS13155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BG454_RS13160	COG0569	domain protein
BG454_RS13165	COG2204	response regulator
BG454_RS13170	COG5000	phosphorelay sensor kinase activity
BG454_RS13175	COG2204	response regulator
BG454_RS13180	COG3852	Histidine kinase
BG454_RS13185	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BG454_RS13190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BG454_RS13190	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BG454_RS13205	COG0175	sulfate reduction
BG454_RS13210	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BG454_RS13220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BG454_RS13220	COG1648	precorrin-2 dehydrogenase activity
BG454_RS13230	COG1116	anion transmembrane transporter activity
BG454_RS13235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BG454_RS13265	COG1201	RNA secondary structure unwinding
BG454_RS13280	COG2983	Belongs to the UPF0260 family
BG454_RS13295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BG454_RS13310	COG1522	sequence-specific DNA binding
BG454_RS13315	COG0686	Belongs to the AlaDH PNT family
BG454_RS13350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BG454_RS13355	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BG454_RS13365	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BG454_RS13370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BG454_RS13375	COG4942	peptidase
BG454_RS13380	COG0800	Aldolase
BG454_RS13385	COG1376	ErfK ybiS ycfS ynhG family protein
BG454_RS13390	COG2010	Cytochrome c
BG454_RS13405	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BG454_RS13410	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BG454_RS13410	COG3743	rRNA binding
BG454_RS13490	COG0114	fumarate hydratase activity
BG454_RS13505	COG1546	Belongs to the CinA family
BG454_RS13505	COG1058	Belongs to the CinA family
BG454_RS13510	COG2867	negative regulation of translational initiation
BG454_RS13515	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BG454_RS13525	COG2010	Cytochrome c
BG454_RS13530	COG0628	permease
BG454_RS13535	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
BG454_RS13540	COG0194	GDP metabolic process
BG454_RS13545	COG1561	YicC-like family, N-terminal region
BG454_RS13555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BG454_RS13570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BG454_RS13605	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BG454_RS13615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG454_RS13645	COG2030	dehydratase
BG454_RS13690	COG0481	GTPase activity
BG454_RS13705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BG454_RS13720	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BG454_RS13725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BG454_RS13730	COG3453	Protein conserved in bacteria
BG454_RS13730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG454_RS13740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG454_RS13745	COG4597	amino acid ABC transporter
BG454_RS13750	COG0765	amino acid transport
BG454_RS13755	COG1126	abc transporter atp-binding protein
BG454_RS13760	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BG454_RS13775	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BG454_RS13780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
BG454_RS13785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BG454_RS13800	COG0275	rRNA processing
BG454_RS13805	COG2001	Belongs to the MraZ family
BG454_RS13810	COG0489	protein tyrosine kinase activity
BG454_RS13825	COG0210	DNA helicase
BG454_RS13830	COG1304	FMN binding
BG454_RS13835	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BG454_RS13840	COG1338	Plays a role in the flagellum-specific transport system
BG454_RS13845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BG454_RS13855	COG1766	The M ring may be actively involved in energy transduction
BG454_RS13875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BG454_RS13885	COG2205	protein histidine kinase activity
BG454_RS13890	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BG454_RS13895	COG1612	heme a metabolic process
BG454_RS13935	COG1473	amidohydrolase
BG454_RS13940	COG0560	Phosphoserine phosphatase
BG454_RS13940	COG3830	Belongs to the UPF0237 family
BG454_RS13950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BG454_RS13955	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BG454_RS13960	COG0501	Belongs to the peptidase M48B family
BG454_RS13970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BG454_RS13975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BG454_RS13980	COG2264	protein methyltransferase activity
BG454_RS13990	COG0142	geranyltranstransferase activity
BG454_RS14010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BG454_RS14035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BG454_RS14040	COG0612	Peptidase, M16
BG454_RS14060	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
BG454_RS14070	COG0109	protoheme IX farnesyltransferase activity
BG454_RS14080	COG0312	modulator of DNA gyrase
BG454_RS14085	COG0758	DNA mediated transformation
BG454_RS14090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BG454_RS14090	COG1754	DNA topoisomerase type I activity
BG454_RS14095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BG454_RS14120	COG4964	Belongs to the GSP D family
BG454_RS14170	COG1522	sequence-specific DNA binding
BG454_RS14175	COG0492	ferredoxin-NADP+ reductase activity
BG454_RS14195	COG2255	four-way junction helicase activity
BG454_RS14200	COG0632	four-way junction helicase activity
BG454_RS14205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BG454_RS14220	COG2264	protein methyltransferase activity
BG454_RS14225	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BG454_RS14235	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BG454_RS14245	COG4974	Belongs to the 'phage' integrase family
BG454_RS14250	COG1183	phosphatidylcholine synthase activity
BG454_RS14255	COG1250	3-hydroxyacyl-CoA dehydrogenase
BG454_RS14260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BG454_RS14270	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BG454_RS14275	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BG454_RS14280	COG2897	thiosulfate sulfurtransferase activity
BG454_RS14295	COG1570	exodeoxyribonuclease VII activity
BG454_RS14310	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG454_RS14315	COG0552	protein localization to endoplasmic reticulum
BG454_RS14320	COG1678	Uncharacterized ACR, COG1678
BG454_RS14330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BG454_RS14340	COG0521	Mo-molybdopterin cofactor biosynthetic process
BG454_RS14345	COG1573	uracil-dna glycosylase
BG454_RS14350	COG0540	Belongs to the ATCase OTCase family
BG454_RS14365	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BG454_RS14375	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BG454_RS14385	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BG454_RS14390	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BG454_RS14405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BG454_RS14420	COG1380	Effector of murein hydrolase LrgA
BG454_RS14430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BG454_RS14460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BG454_RS14465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BG454_RS14480	COG2271	Major facilitator Superfamily
BG454_RS14485	COG2081	HI0933 family
BG454_RS14495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BG454_RS14500	COG1702	phosphate starvation-inducible protein PhoH
BG454_RS14505	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BG454_RS14510	COG1253	flavin adenine dinucleotide binding
BG454_RS14515	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BG454_RS14525	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS14540	COG1250	3-hydroxyacyl-CoA dehydrogenase
BG454_RS14540	COG1024	Enoyl-CoA hydratase
BG454_RS14545	COG0183	Belongs to the thiolase family
BG454_RS14550	COG0625	glutathione transferase activity
BG454_RS14560	COG1960	acyl-CoA dehydrogenase activity
BG454_RS14585	COG0534	Mate efflux family protein
BG454_RS14625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BG454_RS14645	COG2239	Acts as a magnesium transporter
BG454_RS14670	COG0483	inositol monophosphate 1-phosphatase activity
BG454_RS14675	COG0312	modulator of DNA gyrase
BG454_RS14685	COG3243	poly(R)-hydroxyalkanoic acid synthase
BG454_RS14700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BG454_RS14705	COG0174	glutamine synthetase
BG454_RS14710	COG0519	Catalyzes the synthesis of GMP from XMP
BG454_RS14710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BG454_RS14715	COG0174	glutamine synthetase
BG454_RS14740	COG0488	(ABC) transporter
BG454_RS14765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BG454_RS14770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BG454_RS14775	COG3046	protein related to deoxyribodipyrimidine photolyase
BG454_RS14780	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS14790	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BG454_RS14800	COG2171	N-acyltransferase activity
BG454_RS14815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BG454_RS14845	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BG454_RS14955	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BG454_RS14965	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS14985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS14990	COG2186	Transcriptional regulator
BG454_RS14995	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BG454_RS15000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BG454_RS15020	COG0438	transferase activity, transferring glycosyl groups
BG454_RS15025	COG2423	ornithine cyclodeaminase activity
BG454_RS15030	COG3616	Alanine racemase, N-terminal domain
BG454_RS15035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BG454_RS15040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BG454_RS15045	COG1414	Transcriptional regulator
BG454_RS15055	COG1442	glycosyl transferase family 8
BG454_RS15055	COG1216	Glycosyl transferase, family 2
BG454_RS15060	COG1215	transferase activity, transferring glycosyl groups
BG454_RS15100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BG454_RS15105	COG1138	Cytochrome C-type biogenesis protein
BG454_RS15110	COG3088	subunit of a heme lyase
BG454_RS15115	COG1024	Enoyl-CoA hydratase
BG454_RS15120	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
BG454_RS15130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BG454_RS15140	COG0583	DNA-binding transcription factor activity
BG454_RS15155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BG454_RS15160	COG0658	competence protein
BG454_RS15160	COG2333	competence protein COMEC
BG454_RS15165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BG454_RS15180	COG3956	TIGRFAM MazG family protein
BG454_RS15190	COG0425	Belongs to the sulfur carrier protein TusA family
BG454_RS15200	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BG454_RS15205	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BG454_RS15215	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS15225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG454_RS15230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BG454_RS15240	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BG454_RS15245	COG0471	metal ion transport
BG454_RS15245	COG3273	potassium ion transport
BG454_RS15255	COG1692	metallophosphoesterase
BG454_RS15260	COG1122	ATPase activity
BG454_RS15290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG454_RS15300	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
BG454_RS15305	COG2855	membrane
BG454_RS15320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BG454_RS15335	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS15340	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BG454_RS15345	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BG454_RS15355	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
BG454_RS15360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS15365	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BG454_RS15370	COG1609	Transcriptional regulator
BG454_RS15375	COG2207	Transcriptional regulator
BG454_RS15390	COG0573	inorganic phosphate transmembrane transporter activity
BG454_RS15405	COG0704	Plays a role in the regulation of phosphate uptake
BG454_RS15410	COG0745	RESPONSE REGULATOR receiver
BG454_RS15415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BG454_RS15420	COG2218	PFAM glutamate synthase alpha subunit domain protein
BG454_RS15425	COG0069	glutamate synthase activity
BG454_RS15430	COG0174	glutamine synthetase
BG454_RS15455	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS15465	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS15480	COG2200	EAL domain
BG454_RS15485	COG0165	Argininosuccinate lyase
BG454_RS15495	COG0019	diaminopimelate decarboxylase activity
BG454_RS15505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BG454_RS15515	COG2197	response regulator
BG454_RS15520	COG3852	Histidine kinase
BG454_RS15525	COG0024	Methionine aminopeptidase
BG454_RS15530	COG1295	ribonuclease BN
BG454_RS15550	COG0420	3'-5' exonuclease activity
BG454_RS15555	COG4717	serine-type aminopeptidase activity
BG454_RS15575	COG0825	malonyl-CoA metabolic process
BG454_RS15585	COG1132	(ABC) transporter
BG454_RS15610	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
BG454_RS15635	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BG454_RS15640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
BG454_RS15650	COG0457	Tetratricopeptide repeat
BG454_RS15650	COG0705	Rhomboid family
BG454_RS15655	COG0149	triose-phosphate isomerase activity
BG454_RS15665	COG0110	maltose O-acetyltransferase activity
BG454_RS15675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BG454_RS15680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BG454_RS15690	COG1074	ATP-dependent DNA helicase activity
BG454_RS15700	COG0802	atpase or kinase
BG454_RS15705	COG1858	cytochrome C peroxidase
BG454_RS15710	COG0709	Synthesizes selenophosphate from selenide and ATP
BG454_RS15715	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BG454_RS15725	COG1136	(ABC) transporter
BG454_RS15735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BG454_RS15765	COG0459	protein refolding
BG454_RS15775	COG1227	inorganic diphosphatase activity
BG454_RS15785	COG2030	dehydratase
BG454_RS15790	COG0196	riboflavin kinase activity
BG454_RS15810	COG0107	imidazoleglycerol-phosphate synthase activity
BG454_RS15815	COG0140	phosphoribosyl-ATP diphosphatase activity
BG454_RS15825	COG1832	CoA-binding protein
BG454_RS15855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BG454_RS15865	COG1442	glycosyl transferase family 8
BG454_RS15865	COG1216	Glycosyl transferase, family 2
BG454_RS15875	COG1596	polysaccharide export
BG454_RS15880	COG1215	transferase activity, transferring glycosyl groups
BG454_RS15885	COG1215	transferase activity, transferring glycosyl groups
BG454_RS15890	COG3307	-O-antigen
BG454_RS15895	COG2273	Hydrolase Family 16
BG454_RS15900	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BG454_RS15905	COG1215	transferase activity, transferring glycosyl groups
BG454_RS15910	COG0438	transferase activity, transferring glycosyl groups
BG454_RS15925	COG0589	response to stress
BG454_RS15930	COG1473	amidohydrolase
BG454_RS15945	COG0776	regulation of translation
BG454_RS15950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BG454_RS15955	COG0123	including yeast histone deacetylase and acetoin utilization protein
BG454_RS15960	COG1722	exodeoxyribonuclease VII activity
BG454_RS15965	COG0142	geranyltranstransferase activity
BG454_RS15970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BG454_RS15990	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BG454_RS16000	COG0318	PFAM AMP-dependent synthetase and ligase
BG454_RS16015	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS16025	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG454_RS16025	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS16030	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS16045	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG454_RS16050	COG1177	transmembrane transport
BG454_RS16060	COG3842	ATPase activity
BG454_RS16065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BG454_RS16085	COG4948	Mandelate Racemase Muconate Lactonizing
BG454_RS16100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BG454_RS16105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BG454_RS16110	COG0438	transferase activity, transferring glycosyl groups
BG454_RS16115	COG4172	Belongs to the ABC transporter superfamily
BG454_RS16120	COG4239	(ABC) transporter, permease
BG454_RS16125	COG4174	ABC transporter (Permease)
BG454_RS16130	COG4166	transmembrane transport
BG454_RS16140	COG1605	Chorismate mutase
BG454_RS16140	COG0077	Prephenate dehydratase
BG454_RS16145	COG0625	glutathione transferase activity
BG454_RS16195	COG0745	RESPONSE REGULATOR receiver
BG454_RS16205	COG3118	belongs to the thioredoxin family
BG454_RS16215	COG2835	tetraacyldisaccharide 4'-kinase activity
BG454_RS16220	COG0494	nUDIX hydrolase
BG454_RS16225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BG454_RS16230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BG454_RS16235	COG0653	protein targeting
BG454_RS16245	COG2003	Belongs to the UPF0758 family
BG454_RS16265	COG0443	Heat shock 70 kDa protein
BG454_RS16295	COG0604	alcohol dehydrogenase
BG454_RS16340	COG1129	ABC transporter
BG454_RS16355	COG0534	Mate efflux family protein
BG454_RS16360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BG454_RS16375	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
BG454_RS16380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BG454_RS16410	COG0012	GTP binding
BG454_RS16415	COG0159	tryptophan synthase activity
BG454_RS16440	COG1040	competence protein
BG454_RS16450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BG454_RS16485	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS16495	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BG454_RS16510	COG0747	negative chemotaxis
BG454_RS16520	COG0444	Belongs to the ABC transporter superfamily
BG454_RS16530	COG2186	Transcriptional regulator
BG454_RS16560	COG1126	abc transporter atp-binding protein
BG454_RS16565	COG0765	amino acid transport
BG454_RS16570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BG454_RS16610	COG3181	Tripartite tricarboxylate transporter family receptor
BG454_RS16615	COG0028	Belongs to the TPP enzyme family
BG454_RS16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BG454_RS16635	COG1053	succinate dehydrogenase
BG454_RS16660	COG0583	DNA-binding transcription factor activity
BG454_RS16665	COG0251	oxidation-reduction process
BG454_RS16685	COG1648	precorrin-2 dehydrogenase activity
BG454_RS16685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BG454_RS16690	COG1797	cobyrinic acid a,c-diamide synthase activity
BG454_RS16695	COG2875	Belongs to the precorrin methyltransferase family
BG454_RS16710	COG2099	Precorrin-6x reductase
BG454_RS16760	COG0778	Nitroreductase
BG454_RS16765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BG454_RS16775	COG1120	ATPase activity
BG454_RS16785	COG5002	protein histidine kinase activity
BG454_RS16790	COG0745	RESPONSE REGULATOR receiver
BG454_RS16810	COG2885	chlorophyll binding
BG454_RS16865	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BG454_RS16875	COG1609	Transcriptional regulator
BG454_RS16880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS16885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS16885	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG454_RS16890	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
BG454_RS16915	COG0673	inositol 2-dehydrogenase activity
BG454_RS16935	COG2311	Membrane
BG454_RS16970	COG1228	amidohydrolase
BG454_RS16975	COG0583	DNA-binding transcription factor activity
BG454_RS16980	COG2515	1-aminocyclopropane-1-carboxylate deaminase
BG454_RS16985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
BG454_RS16995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BG454_RS17020	COG2423	ornithine cyclodeaminase activity
BG454_RS17025	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BG454_RS17040	COG0628	permease
BG454_RS17050	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BG454_RS17075	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BG454_RS17080	COG0563	adenylate kinase activity
BG454_RS17090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BG454_RS17095	COG0516	GMP reductase activity
BG454_RS17095	COG0517	IMP dehydrogenase activity
BG454_RS17105	COG0745	RESPONSE REGULATOR receiver
BG454_RS17110	COG5002	protein histidine kinase activity
BG454_RS17110	COG2176	DNA-directed DNA polymerase activity
BG454_RS17120	COG1492	cobalamin metabolic process
BG454_RS17150	COG0513	Belongs to the DEAD box helicase family
BG454_RS17155	COG3842	ATPase activity
BG454_RS17160	COG0366	Alpha amylase catalytic
BG454_RS17165	COG0395	ABC-type sugar transport system, permease component
BG454_RS17170	COG1175	transmembrane transport
BG454_RS17175	COG1653	transport
BG454_RS17180	COG1609	Transcriptional regulator
BG454_RS17185	COG2723	6-phospho-beta-galactosidase activity
BG454_RS17190	COG0837	glucose binding
BG454_RS17210	COG0489	protein tyrosine kinase activity
BG454_RS17220	COG0437	4 iron, 4 sulfur cluster binding
BG454_RS17225	COG3383	formate dehydrogenase (NAD+) activity
BG454_RS17225	COG0243	molybdopterin cofactor binding
BG454_RS17270	COG1793	dna ligase
BG454_RS17285	COG3302	dmso reductase anchor subunit
BG454_RS17290	COG0437	4 iron, 4 sulfur cluster binding
BG454_RS17295	COG0243	molybdopterin cofactor binding
BG454_RS17315	COG1595	DNA-templated transcription, initiation
BG454_RS17340	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BG454_RS17345	COG0745	RESPONSE REGULATOR receiver
BG454_RS17350	COG0346	lactoylglutathione lyase activity
BG454_RS17365	COG0778	Nitroreductase
BG454_RS17375	COG3022	response to hydroperoxide
BG454_RS17385	COG0514	ATP-dependent DNA helicase (RecQ)
BG454_RS17415	COG0285	dihydrofolate synthase activity
BG454_RS17420	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BG454_RS17435	COG2223	nitrite transmembrane transporter activity
BG454_RS17445	COG2326	polyphosphate kinase activity
BG454_RS17455	COG0577	efflux transmembrane transporter activity
BG454_RS17460	COG0446	pyridine nucleotide-disulphide oxidoreductase
BG454_RS17460	COG1902	pentaerythritol trinitrate reductase activity
BG454_RS17475	COG1349	DNA-binding transcription factor activity
BG454_RS17485	COG0405	Gamma-glutamyltransferase
BG454_RS17495	COG0628	permease
BG454_RS17505	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BG454_RS17510	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BG454_RS17530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BG454_RS17540	COG3750	Belongs to the UPF0335 family
BG454_RS17565	COG2989	Protein conserved in bacteria
BG454_RS17580	COG2081	HI0933 family
BG454_RS17585	COG5265	(ABC) transporter
BG454_RS17590	COG2076	Multidrug Resistance protein
BG454_RS17600	COG1611	Belongs to the LOG family
BG454_RS17610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BG454_RS17635	COG1858	cytochrome C peroxidase
BG454_RS17650	COG1028	Short-chain dehydrogenase reductase Sdr
BG454_RS17665	COG1054	Belongs to the UPF0176 family
BG454_RS17710	COG1320	monovalent cation:proton antiporter activity
BG454_RS17725	COG0651	ATP synthesis coupled electron transport
BG454_RS17730	COG0651	ATP synthesis coupled electron transport
BG454_RS17735	COG0651	ATP synthesis coupled electron transport
BG454_RS17750	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BG454_RS17755	COG0523	cobalamin synthesis protein
BG454_RS17760	COG1072	(Pantothenic acid kinase))
BG454_RS17785	COG1175	transmembrane transport
BG454_RS17790	COG1653	transport
BG454_RS17795	COG1609	Transcriptional regulator
BG454_RS17800	COG0589	response to stress
BG454_RS17805	COG0659	secondary active sulfate transmembrane transporter activity
BG454_RS17825	COG1228	amidohydrolase
BG454_RS17830	COG2986	histidine ammonia-lyase
BG454_RS17840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BG454_RS17910	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS17915	COG0601	transmembrane transport
BG454_RS17925	COG4948	Mandelate Racemase Muconate Lactonizing
BG454_RS18005	COG0348	domain, Protein
BG454_RS18005	COG3901	Regulator of nitric oxide reductase transcription
BG454_RS18015	COG1959	2 iron, 2 sulfur cluster binding
BG454_RS18035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BG454_RS18040	COG4608	Belongs to the ABC transporter superfamily
BG454_RS18045	COG0444	Belongs to the ABC transporter superfamily
BG454_RS18050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BG454_RS18055	COG0601	transmembrane transport
BG454_RS18060	COG0747	negative chemotaxis
BG454_RS18070	COG0402	S-adenosylhomocysteine deaminase activity
BG454_RS18085	COG1396	sequence-specific DNA binding
BG454_RS18100	COG0842	Transport permease protein
BG454_RS18115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BG454_RS18130	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BG454_RS18135	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BG454_RS18155	COG0438	transferase activity, transferring glycosyl groups
BG454_RS18155	COG1216	Glycosyl transferase, family 2
BG454_RS18200	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BG454_RS18235	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
BG454_RS18295	COG0402	S-adenosylhomocysteine deaminase activity
BG454_RS18325	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BG454_RS18330	COG1349	DNA-binding transcription factor activity
BG454_RS18335	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BG454_RS18340	COG3842	ATPase activity
BG454_RS18345	COG1176	ABC-type spermidine putrescine transport system, permease component I
BG454_RS18350	COG1177	transmembrane transport
BG454_RS18355	COG1012	belongs to the aldehyde dehydrogenase family
BG454_RS18360	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BG454_RS18375	COG1609	Transcriptional regulator
BG454_RS18380	COG1129	ABC transporter
BG454_RS18385	COG1172	Belongs to the binding-protein-dependent transport system permease family
BG454_RS18420	COG0045	succinate-CoA ligase (ADP-forming) activity
BG454_RS18445	COG3181	Tripartite tricarboxylate transporter family receptor
BG454_RS18460	COG1522	sequence-specific DNA binding
BG454_RS18480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BG454_RS18530	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
BG454_RS18535	COG2270	Major facilitator Superfamily
BG454_RS18540	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
BG454_RS18545	COG0737	Belongs to the 5'-nucleotidase family
BG454_RS18550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BG454_RS18565	COG0306	phosphate transporter
BG454_RS18580	COG1968	undecaprenyl-diphosphatase activity
BG454_RS18585	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BG454_RS18595	COG0779	Required for maturation of 30S ribosomal subunits
BG454_RS18610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BG454_RS18625	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BG454_RS18630	COG2226	methyltransferase
BG454_RS18635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
BG454_RS18645	COG0268	Binds directly to 16S ribosomal RNA