locus-tag	class	description
A3857_RS00060	COG0662	Cupin 2, conserved barrel domain protein
A3857_RS00065	COG0604	alcohol dehydrogenase
A3857_RS00070	COG1309	transcriptional regulator
A3857_RS00075	COG0488	(ABC) transporter
A3857_RS00080	COG1120	ATPase activity
A3857_RS00090	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3857_RS00095	COG4774	siderophore transport
A3857_RS00100	COG1940	carbohydrate kinase activity
A3857_RS00110	COG1175	transmembrane transport
A3857_RS00115	COG0395	ABC-type sugar transport system, permease component
A3857_RS00125	COG2971	BadF BadG BcrA BcrD
A3857_RS00140	COG1349	DNA-binding transcription factor activity
A3857_RS00155	COG0601	transmembrane transport
A3857_RS00170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3857_RS00210	COG1519	Transferase
A3857_RS00215	COG1663	tetraacyldisaccharide 4'-kinase activity
A3857_RS00235	COG1194	a g-specific adenine glycosylase
A3857_RS00275	COG0019	diaminopimelate decarboxylase activity
A3857_RS00295	COG4172	Belongs to the ABC transporter superfamily
A3857_RS00300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS00305	COG0601	transmembrane transport
A3857_RS00310	COG4166	transmembrane transport
A3857_RS00330	COG1309	transcriptional regulator
A3857_RS00335	COG5507	3-demethylubiquinone-9 3-methyltransferase
A3857_RS00345	COG3118	belongs to the thioredoxin family
A3857_RS00360	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3857_RS00365	COG0154	amidase activity
A3857_RS00370	COG0436	Aminotransferase
A3857_RS00375	COG1674	ftsk spoiiie
A3857_RS00395	COG0405	Gamma-glutamyltransferase
A3857_RS00425	COG0564	pseudouridine synthase activity
A3857_RS00460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3857_RS00465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A3857_RS00485	COG0133	tryptophan synthase activity
A3857_RS00500	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
A3857_RS00510	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
A3857_RS00515	COG1999	signal sequence binding
A3857_RS00520	COG2205	protein histidine kinase activity
A3857_RS00525	COG2205	protein histidine kinase activity
A3857_RS00535	COG3178	'Phosphotransferase
A3857_RS00540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3857_RS00545	COG2887	Belongs to the helicase family. UvrD subfamily
A3857_RS00550	COG1074	ATP-dependent DNA helicase activity
A3857_RS00565	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3857_RS00570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A3857_RS00575	COG1696	Membrane protein involved in D-alanine export
A3857_RS00605	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3857_RS00610	COG0463	Glycosyl transferase, family 2
A3857_RS00620	COG0577	efflux transmembrane transporter activity
A3857_RS00625	COG1136	(ABC) transporter
A3857_RS00675	COG1414	Transcriptional regulator
A3857_RS00685	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
A3857_RS00690	COG3257	ureidoglycine aminohydrolase activity
A3857_RS00700	COG2351	hydroxyisourate hydrolase activity
A3857_RS00715	COG0538	isocitrate dehydrogenase activity
A3857_RS00725	COG0318	PFAM AMP-dependent synthetase and ligase
A3857_RS00730	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3857_RS00735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3857_RS00740	COG0628	permease
A3857_RS00760	COG0174	glutamine synthetase
A3857_RS00765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A3857_RS00770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3857_RS00795	COG3038	cytochrome b561
A3857_RS00800	COG0529	Catalyzes the synthesis of activated sulfate
A3857_RS00800	COG2046	Belongs to the sulfate adenylyltransferase family
A3857_RS00805	COG0492	ferredoxin-NADP+ reductase activity
A3857_RS00810	COG1522	sequence-specific DNA binding
A3857_RS00815	COG1496	oxidoreductase activity
A3857_RS00825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A3857_RS00840	COG0745	RESPONSE REGULATOR receiver
A3857_RS00850	COG0835	chemotaxis
A3857_RS00855	COG0835	chemotaxis
A3857_RS00865	COG2201	protein-glutamate methylesterase activity
A3857_RS00875	COG0435	Glutathione S-transferase
A3857_RS00880	COG2204	response regulator
A3857_RS00895	COG0281	malic enzyme
A3857_RS00895	COG0280	phosphate acetyltransferase
A3857_RS00900	COG0295	cytidine deaminase activity
A3857_RS00905	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3857_RS00910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A3857_RS00915	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
A3857_RS00920	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3857_RS00950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3857_RS00960	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3857_RS00965	COG2186	Transcriptional regulator
A3857_RS00970	COG1802	Transcriptional regulator
A3857_RS00975	COG1063	alcohol dehydrogenase
A3857_RS00980	COG0246	Mannitol dehydrogenase
A3857_RS00985	COG2721	sulfolactate sulfo-lyase activity
A3857_RS00990	COG4191	Histidine kinase
A3857_RS00995	COG2204	response regulator
A3857_RS01000	COG2358	TRAP transporter, solute receptor (TAXI family
A3857_RS01045	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A3857_RS01080	COG3920	Histidine kinase
A3857_RS01085	COG2197	response regulator
A3857_RS01170	COG0730	response to heat
A3857_RS01250	COG3750	Belongs to the UPF0335 family
A3857_RS01275	COG1609	Transcriptional regulator
A3857_RS01290	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A3857_RS01300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A3857_RS01310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3857_RS01325	COG0736	holo-[acyl-carrier-protein] synthase activity
A3857_RS01330	COG0681	Belongs to the peptidase S26 family
A3857_RS01340	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A3857_RS01350	COG1381	Involved in DNA repair and RecF pathway recombination
A3857_RS01365	COG0745	RESPONSE REGULATOR receiver
A3857_RS01370	COG2205	protein histidine kinase activity
A3857_RS01380	COG1660	Displays ATPase and GTPase activities
A3857_RS01390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3857_RS01400	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3857_RS01420	COG2096	Adenosyltransferase
A3857_RS01430	COG0300	oxidoreductase activity
A3857_RS01440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3857_RS01485	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A3857_RS01500	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3857_RS01505	COG0697	spore germination
A3857_RS01520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3857_RS01535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3857_RS01575	COG0255	Belongs to the universal ribosomal protein uL29 family
A3857_RS01635	COG0201	protein transport
A3857_RS01640	COG0563	adenylate kinase activity
A3857_RS01670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3857_RS01675	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3857_RS01685	COG0564	pseudouridine synthase activity
A3857_RS01695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3857_RS01700	COG4597	amino acid ABC transporter
A3857_RS01705	COG0765	amino acid transport
A3857_RS01710	COG1126	abc transporter atp-binding protein
A3857_RS01745	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A3857_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3857_RS01765	COG0072	phenylalanine-tRNA ligase activity
A3857_RS01765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3857_RS01795	COG0469	pyruvate kinase activity
A3857_RS01810	COG4948	Mandelate Racemase Muconate Lactonizing
A3857_RS01840	COG2133	pyrroloquinoline quinone binding
A3857_RS01865	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A3857_RS01900	COG1609	Transcriptional regulator
A3857_RS01905	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3857_RS01905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3857_RS01910	COG1105	Belongs to the carbohydrate kinase PfkB family
A3857_RS01915	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3857_RS01915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A3857_RS01920	COG1742	UPF0060 membrane protein
A3857_RS01925	COG0789	Transcriptional regulator
A3857_RS01930	COG2217	Heavy metal translocating P-type atpase
A3857_RS01935	COG0629	single-stranded DNA binding
A3857_RS01940	COG0741	lytic transglycosylase activity
A3857_RS01945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3857_RS01950	COG2032	superoxide dismutase activity
A3857_RS01955	COG1862	Preprotein translocase
A3857_RS01960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3857_RS01965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3857_RS01970	COG3737	Protein of unknown function (DUF498/DUF598)
A3857_RS01975	COG4133	protoheme IX ABC transporter activity
A3857_RS01980	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3857_RS01985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3857_RS01995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3857_RS02000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3857_RS02015	COG0180	Tryptophanyl-tRNA synthetase
A3857_RS02025	COG0728	peptidoglycan biosynthetic process
A3857_RS02030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A3857_RS02040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A3857_RS02045	COG0792	nuclease activity
A3857_RS02050	COG0189	ligase activity
A3857_RS02055	COG0606	chelatase, subunit chli
A3857_RS02065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A3857_RS02070	COG1918	ferrous iron import across plasma membrane
A3857_RS02080	COG3685	Protein conserved in bacteria
A3857_RS02085	COG0243	molybdopterin cofactor binding
A3857_RS02090	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A3857_RS02095	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3857_RS02105	COG0312	modulator of DNA gyrase
A3857_RS02145	COG0612	Peptidase, M16
A3857_RS02165	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3857_RS02170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3857_RS02175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3857_RS02190	COG2917	probably involved in intracellular septation
A3857_RS02200	COG0552	protein localization to endoplasmic reticulum
A3857_RS02210	COG1570	exodeoxyribonuclease VII activity
A3857_RS02220	COG0151	Belongs to the GarS family
A3857_RS02225	COG0469	pyruvate kinase activity
A3857_RS02230	COG0527	aspartate kinase activity
A3857_RS02250	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3857_RS02255	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3857_RS02265	COG0752	glycyl-tRNA synthetase alpha subunit
A3857_RS02275	COG0751	glycine-tRNA ligase activity
A3857_RS02280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3857_RS02280	COG0574	Belongs to the PEP-utilizing enzyme family
A3857_RS02290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A3857_RS02300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3857_RS02310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A3857_RS02315	COG1522	sequence-specific DNA binding
A3857_RS02320	COG1522	sequence-specific DNA binding
A3857_RS02345	COG1802	Transcriptional regulator
A3857_RS02360	COG0505	Belongs to the CarA family
A3857_RS02380	COG0321	lipoyl(octanoyl) transferase activity
A3857_RS02395	COG3842	ATPase activity
A3857_RS02405	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3857_RS02410	COG1177	transmembrane transport
A3857_RS02425	COG0670	Belongs to the BI1 family
A3857_RS02435	COG0583	DNA-binding transcription factor activity
A3857_RS02440	COG0604	alcohol dehydrogenase
A3857_RS02440	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS02440	COG3321	synthase
A3857_RS02455	COG3773	Cell wall hydrolase
A3857_RS02460	COG0668	transmembrane transport
A3857_RS02465	COG0402	S-adenosylhomocysteine deaminase activity
A3857_RS02470	COG2239	Acts as a magnesium transporter
A3857_RS02475	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3857_RS02525	COG4964	Belongs to the GSP D family
A3857_RS02545	COG0741	lytic transglycosylase activity
A3857_RS02570	COG0583	DNA-binding transcription factor activity
A3857_RS02600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A3857_RS02605	COG2258	MOSC domain
A3857_RS02620	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3857_RS02625	COG1268	BioY protein
A3857_RS02635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3857_RS02640	COG0730	response to heat
A3857_RS02645	COG0305	Participates in initiation and elongation during chromosome replication
A3857_RS02650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3857_RS02655	COG0418	dihydroorotase activity
A3857_RS02680	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A3857_RS02690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A3857_RS02710	COG0175	sulfate reduction
A3857_RS02715	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3857_RS02725	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3857_RS02725	COG1648	precorrin-2 dehydrogenase activity
A3857_RS02730	COG1522	sequence-specific DNA binding
A3857_RS02740	COG0149	triose-phosphate isomerase activity
A3857_RS02750	COG2151	metal-sulfur cluster biosynthetic enzyme
A3857_RS02765	COG1278	Cold shock
A3857_RS02770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3857_RS02805	COG3436	PFAM IS66 Orf2 family protein
A3857_RS02855	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3857_RS02860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A3857_RS02865	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A3857_RS02875	COG2166	iron-sulfur cluster assembly
A3857_RS02885	COG0006	proline dipeptidase activity
A3857_RS02910	COG0484	heat shock protein binding
A3857_RS02920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
A3857_RS02930	COG0308	aminopeptidase N
A3857_RS02935	COG0204	Acyl-transferase
A3857_RS02940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3857_RS02950	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3857_RS02965	COG0525	valine-tRNA ligase activity
A3857_RS02995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3857_RS03000	COG2333	competence protein COMEC
A3857_RS03000	COG0658	competence protein
A3857_RS03005	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3857_RS03010	COG0303	'Molybdopterin
A3857_RS03020	COG0134	indole-3-glycerol-phosphate synthase activity
A3857_RS03025	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3857_RS03040	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3857_RS03060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3857_RS03065	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3857_RS03075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3857_RS03085	COG1643	Atp-dependent helicase
A3857_RS03095	COG1703	isobutyryl-CoA mutase activity
A3857_RS03135	COG1858	cytochrome C peroxidase
A3857_RS03150	COG1278	Cold shock
A3857_RS03165	COG0583	DNA-binding transcription factor activity
A3857_RS03180	COG3920	Histidine kinase
A3857_RS03180	COG2202	Pas domain
A3857_RS03370	COG4695	Portal protein
A3857_RS03440	COG3750	Belongs to the UPF0335 family
A3857_RS03475	COG0556	nucleotide-excision repair
A3857_RS03505	COG0481	GTPase activity
A3857_RS03515	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A3857_RS03520	COG0210	DNA helicase
A3857_RS03525	COG3135	benzoate transporter
A3857_RS03535	COG0489	protein tyrosine kinase activity
A3857_RS03545	COG0275	rRNA processing
A3857_RS03560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3857_RS03580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A3857_RS03600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A3857_RS03615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A3857_RS03625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3857_RS03630	COG0849	cell division
A3857_RS03635	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3857_RS03640	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A3857_RS03645	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3857_RS03660	COG0277	FAD linked oxidase domain protein
A3857_RS03675	COG5012	cobalamin binding
A3857_RS03685	COG0646	methionine synthase
A3857_RS03685	COG1410	methionine synthase
A3857_RS03695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3857_RS03700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3857_RS03705	COG0047	phosphoribosylformylglycinamidine synthase activity
A3857_RS03715	COG2204	response regulator
A3857_RS03730	COG0785	Cytochrome C biogenesis protein
A3857_RS03750	COG0114	fumarate hydratase activity
A3857_RS03770	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3857_RS03775	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3857_RS03780	COG0415	Belongs to the DNA photolyase family
A3857_RS03785	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3857_RS03795	COG0494	nUDIX hydrolase
A3857_RS03805	COG3264	Mechanosensitive ion channel
A3857_RS03805	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
A3857_RS03810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3857_RS03815	COG0463	Glycosyl transferase, family 2
A3857_RS03840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A3857_RS03845	COG1177	transmembrane transport
A3857_RS03860	COG3842	ATPase activity
A3857_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS03885	COG1522	sequence-specific DNA binding
A3857_RS03905	COG0483	inositol monophosphate 1-phosphatase activity
A3857_RS03910	COG0306	phosphate transporter
A3857_RS03915	COG0583	DNA-binding transcription factor activity
A3857_RS03925	COG1268	BioY protein
A3857_RS03930	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A3857_RS03935	COG1122	ATPase activity
A3857_RS03945	COG0758	DNA mediated transformation
A3857_RS03950	COG1754	DNA topoisomerase type I activity
A3857_RS03950	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3857_RS03970	COG1309	transcriptional regulator
A3857_RS03975	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS03980	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
A3857_RS03990	COG3800	Transcriptional regulator
A3857_RS03990	COG1396	sequence-specific DNA binding
A3857_RS04005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3857_RS04030	COG4770	biotin carboxylase activity
A3857_RS04040	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3857_RS04040	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3857_RS04045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3857_RS04050	COG0509	glycine decarboxylation via glycine cleavage system
A3857_RS04060	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3857_RS04060	COG1024	Enoyl-CoA hydratase
A3857_RS04065	COG0183	Belongs to the thiolase family
A3857_RS04075	COG1960	acyl-CoA dehydrogenase activity
A3857_RS04100	COG0534	Mate efflux family protein
A3857_RS04110	COG0730	response to heat
A3857_RS04115	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3857_RS04120	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3857_RS04125	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3857_RS04130	COG3845	ABC transporter
A3857_RS04135	COG1744	ABC transporter substrate-binding protein PnrA-like
A3857_RS04145	COG1214	PFAM Peptidase M22, glycoprotease
A3857_RS04150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A3857_RS04165	COG2514	catechol 2,3-dioxygenase activity
A3857_RS04170	COG1376	ErfK ybiS ycfS ynhG family protein
A3857_RS04190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3857_RS04195	COG3042	response to heat
A3857_RS04205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3857_RS04220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A3857_RS04250	COG1573	uracil-dna glycosylase
A3857_RS04275	COG2814	Major facilitator Superfamily
A3857_RS04290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A3857_RS04295	COG1832	CoA-binding protein
A3857_RS04300	COG0140	phosphoribosyl-ATP diphosphatase activity
A3857_RS04305	COG0107	imidazoleglycerol-phosphate synthase activity
A3857_RS04310	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3857_RS04320	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3857_RS04330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3857_RS04360	COG1132	(ABC) transporter
A3857_RS04365	COG0318	PFAM AMP-dependent synthetase and ligase
A3857_RS04370	COG1490	D-aminoacyl-tRNA deacylase activity
A3857_RS04380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3857_RS04385	COG1238	metal cluster binding
A3857_RS04430	COG1187	pseudouridine synthase activity
A3857_RS04440	COG0590	tRNA wobble adenosine to inosine editing
A3857_RS04445	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3857_RS04460	COG0154	amidase activity
A3857_RS04470	COG3023	N-Acetylmuramoyl-L-alanine amidase
A3857_RS04500	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3857_RS04515	COG1022	Amp-dependent synthetase and ligase
A3857_RS04545	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3857_RS04550	COG0287	Prephenate dehydrogenase
A3857_RS04565	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A3857_RS04595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3857_RS04615	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3857_RS04625	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A3857_RS04640	COG2983	Belongs to the UPF0260 family
A3857_RS04645	COG0196	riboflavin kinase activity
A3857_RS04650	COG2030	dehydratase
A3857_RS04660	COG1227	inorganic diphosphatase activity
A3857_RS04690	COG0656	L-ascorbic acid biosynthetic process
A3857_RS04700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS04710	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS04715	COG0174	glutamine synthetase
A3857_RS04720	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3857_RS04745	COG0772	Belongs to the SEDS family
A3857_RS04750	COG0768	penicillin binding
A3857_RS04775	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3857_RS04800	COG0655	NAD(P)H dehydrogenase (quinone) activity
A3857_RS04830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3857_RS04850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3857_RS04855	COG0259	pyridoxamine-phosphate oxidase activity
A3857_RS04965	COG2188	Transcriptional regulator
A3857_RS04970	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS04975	COG0235	Class ii aldolase
A3857_RS04985	COG1129	ABC transporter
A3857_RS04990	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS04995	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS05030	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
A3857_RS05035	COG0156	8-amino-7-oxononanoate synthase activity
A3857_RS05040	COG1063	alcohol dehydrogenase
A3857_RS05045	COG2124	cytochrome p450
A3857_RS05055	COG0753	catalase activity
A3857_RS05065	COG2094	Belongs to the DNA glycosylase MPG family
A3857_RS05125	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3857_RS05155	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A3857_RS05160	COG1177	transmembrane transport
A3857_RS05170	COG3842	ATPase activity
A3857_RS05190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3857_RS05195	COG1120	ATPase activity
A3857_RS05205	COG0784	Response regulator, receiver
A3857_RS05205	COG5002	protein histidine kinase activity
A3857_RS05215	COG0564	pseudouridine synthase activity
A3857_RS05235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3857_RS05235	COG1793	dna ligase
A3857_RS05245	COG2308	Evidence 4 Homologs of previously reported genes of
A3857_RS05290	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A3857_RS05295	COG1329	Transcriptional regulator
A3857_RS05300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3857_RS05305	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3857_RS05320	COG2968	Membrane
A3857_RS05325	COG2873	o-acetylhomoserine
A3857_RS05335	COG0745	RESPONSE REGULATOR receiver
A3857_RS05340	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3857_RS05355	COG0745	RESPONSE REGULATOR receiver
A3857_RS05365	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A3857_RS05370	COG0840	transmembrane signaling receptor activity
A3857_RS05380	COG0840	transmembrane signaling receptor activity
A3857_RS05385	COG0745	RESPONSE REGULATOR receiver
A3857_RS05395	COG0366	Alpha amylase catalytic
A3857_RS05405	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3857_RS05415	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A3857_RS05430	COG4221	oxidoreductase activity
A3857_RS05435	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3857_RS05455	COG1127	ABC transporter
A3857_RS05460	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3857_RS05465	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3857_RS05480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3857_RS05485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3857_RS05500	COG4695	Portal protein
A3857_RS05580	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3857_RS05585	COG0022	dehydrogenase e1 component
A3857_RS05585	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3857_RS05590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A3857_RS05595	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A3857_RS05600	COG1830	Aldolase
A3857_RS05605	COG0126	phosphoglycerate kinase activity
A3857_RS05620	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A3857_RS05625	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
A3857_RS05645	COG0697	spore germination
A3857_RS05655	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3857_RS05685	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3857_RS05690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3857_RS05695	COG0546	phosphoglycolate phosphatase activity
A3857_RS05705	COG1960	acyl-CoA dehydrogenase activity
A3857_RS05710	COG3047	cAMP biosynthetic process
A3857_RS05715	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3857_RS05720	COG4770	biotin carboxylase activity
A3857_RS05730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A3857_RS05750	COG0649	NAD binding
A3857_RS05785	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3857_RS05820	COG1007	ATP synthesis coupled electron transport
A3857_RS05845	COG0513	Belongs to the DEAD box helicase family
A3857_RS05855	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS05860	COG3842	ATPase activity
A3857_RS05865	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3857_RS05875	COG0805	protein transport
A3857_RS05885	COG0739	heme binding
A3857_RS05885	COG1388	LysM domain
A3857_RS05895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3857_RS05915	COG2273	Hydrolase Family 16
A3857_RS05920	COG1215	transferase activity, transferring glycosyl groups
A3857_RS05925	COG1215	transferase activity, transferring glycosyl groups
A3857_RS05960	COG1132	(ABC) transporter
A3857_RS05970	COG0489	protein tyrosine kinase activity
A3857_RS05970	COG3206	protein involved in exopolysaccharide biosynthesis
A3857_RS05980	COG1215	transferase activity, transferring glycosyl groups
A3857_RS05985	COG0438	transferase activity, transferring glycosyl groups
A3857_RS05995	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3857_RS06010	COG0693	protein deglycase activity
A3857_RS06015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A3857_RS06035	COG3791	Glutathione-dependent formaldehyde-activating
A3857_RS06040	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
A3857_RS06060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3857_RS06090	COG1131	(ABC) transporter
A3857_RS06125	COG0784	Response regulator, receiver
A3857_RS06125	COG2198	Histidine kinase
A3857_RS06125	COG2205	protein histidine kinase activity
A3857_RS06140	COG1116	anion transmembrane transporter activity
A3857_RS06150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS06155	COG0745	RESPONSE REGULATOR receiver
A3857_RS06165	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3857_RS06170	COG0581	inorganic phosphate transmembrane transporter activity
A3857_RS06175	COG0573	inorganic phosphate transmembrane transporter activity
A3857_RS06205	COG0717	Belongs to the dCTP deaminase family
A3857_RS06225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3857_RS06250	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3857_RS06260	COG0482	sulfurtransferase activity
A3857_RS06270	COG0745	RESPONSE REGULATOR receiver
A3857_RS06275	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3857_RS06280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3857_RS06295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3857_RS06300	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3857_RS06305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A3857_RS06310	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A3857_RS06315	COG5425	PFAM Usg family protein
A3857_RS06325	COG1138	Cytochrome C-type biogenesis protein
A3857_RS06330	COG3088	subunit of a heme lyase
A3857_RS06335	COG1024	Enoyl-CoA hydratase
A3857_RS06340	COG0440	acetolactate synthase activity
A3857_RS06345	COG0028	Belongs to the TPP enzyme family
A3857_RS06355	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A3857_RS06375	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A3857_RS06385	COG0800	Aldolase
A3857_RS06390	COG0129	dihydroxy-acid dehydratase activity
A3857_RS06445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3857_RS06470	COG1295	ribonuclease BN
A3857_RS06475	COG1454	alcohol dehydrogenase
A3857_RS06480	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A3857_RS06495	COG0395	ABC-type sugar transport system, permease component
A3857_RS06505	COG3842	ATPase activity
A3857_RS06510	COG3842	ATPase activity
A3857_RS06580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3857_RS06595	COG4235	cytochrome complex assembly
A3857_RS06600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS06615	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3857_RS06615	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3857_RS06625	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3857_RS06625	COG2755	lipolytic protein G-D-S-L family
A3857_RS06635	COG1611	Belongs to the LOG family
A3857_RS06645	COG5265	(ABC) transporter
A3857_RS06670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS06675	COG0601	transmembrane transport
A3857_RS06685	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A3857_RS06690	COG0528	UMP kinase activity
A3857_RS06695	COG0233	cytoplasmic translational termination
A3857_RS06700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3857_RS06705	COG0575	Belongs to the CDS family
A3857_RS06710	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A3857_RS06715	COG0750	zinc metalloprotease
A3857_RS06725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3857_RS06740	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3857_RS06745	COG3494	Protein of unknown function (DUF1009)
A3857_RS06750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3857_RS06755	COG0488	(ABC) transporter
A3857_RS06780	COG0215	cysteine-tRNA ligase activity
A3857_RS06785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3857_RS06800	COG2814	Major facilitator Superfamily
A3857_RS06805	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3857_RS06830	COG0431	NADPH-dependent FMN reductase
A3857_RS06840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A3857_RS06850	COG0166	Belongs to the GPI family
A3857_RS06855	COG0251	oxidation-reduction process
A3857_RS06860	COG2897	thiosulfate sulfurtransferase activity
A3857_RS06865	COG2391	methyltransferase activity
A3857_RS06900	COG0438	transferase activity, transferring glycosyl groups
A3857_RS06920	COG0582	viral genome integration into host DNA
A3857_RS07040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A3857_RS07050	COG0248	Ppx GppA phosphatase
A3857_RS07055	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A3857_RS07060	COG3108	Peptidase M15
A3857_RS07070	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A3857_RS07090	COG0753	catalase activity
A3857_RS07115	COG2010	Cytochrome c
A3857_RS07120	COG3909	cytochrome
A3857_RS07125	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A3857_RS07130	COG2867	negative regulation of translational initiation
A3857_RS07140	COG2801	Transposase and inactivated derivatives
A3857_RS07170	COG2313	pseudouridylate synthase activity
A3857_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS07180	COG4166	transmembrane transport
A3857_RS07210	COG2814	Major facilitator Superfamily
A3857_RS07215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A3857_RS07235	COG2084	Dehydrogenase
A3857_RS07250	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3857_RS07265	COG0569	domain protein
A3857_RS07270	COG2204	response regulator
A3857_RS07275	COG5000	phosphorelay sensor kinase activity
A3857_RS07280	COG2204	response regulator
A3857_RS07285	COG3852	Histidine kinase
A3857_RS07290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A3857_RS07295	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A3857_RS07310	COG1058	Belongs to the CinA family
A3857_RS07310	COG1546	Belongs to the CinA family
A3857_RS07315	COG2081	HI0933 family
A3857_RS07370	COG2099	Precorrin-6x reductase
A3857_RS07385	COG2875	Belongs to the precorrin methyltransferase family
A3857_RS07390	COG1648	precorrin-2 dehydrogenase activity
A3857_RS07390	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A3857_RS07405	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3857_RS07410	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3857_RS07425	COG4974	Belongs to the 'phage' integrase family
A3857_RS07430	COG4536	flavin adenine dinucleotide binding
A3857_RS07445	COG5598	trimethylamine methyltransferase
A3857_RS07460	COG1127	ABC transporter
A3857_RS07465	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A3857_RS07485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3857_RS07490	COG1902	pentaerythritol trinitrate reductase activity
A3857_RS07495	COG0343	queuine tRNA-ribosyltransferase activity
A3857_RS07500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3857_RS07530	COG0459	protein refolding
A3857_RS07535	COG2151	metal-sulfur cluster biosynthetic enzyme
A3857_RS07535	COG0489	protein tyrosine kinase activity
A3857_RS07555	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A3857_RS07590	COG0516	GMP reductase activity
A3857_RS07590	COG0517	IMP dehydrogenase activity
A3857_RS07605	COG3842	ATPase activity
A3857_RS07610	COG0395	ABC-type sugar transport system, permease component
A3857_RS07615	COG1175	transmembrane transport
A3857_RS07620	COG1653	transport
A3857_RS07630	COG2723	6-phospho-beta-galactosidase activity
A3857_RS07635	COG0837	glucose binding
A3857_RS07660	COG2205	protein histidine kinase activity
A3857_RS07660	COG2198	Histidine kinase
A3857_RS07660	COG0784	Response regulator, receiver
A3857_RS07675	COG0033	Phosphoglucomutase
A3857_RS07685	COG0297	glycogen (starch) synthase activity
A3857_RS07695	COG0058	SHG alpha-glucan phosphorylase activity
A3857_RS07700	COG1959	2 iron, 2 sulfur cluster binding
A3857_RS07730	COG0488	(ABC) transporter
A3857_RS07735	COG2095	MarC family integral membrane protein
A3857_RS07740	COG3577	Aspartyl protease
A3857_RS07750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3857_RS07755	COG0795	lipopolysaccharide-transporting ATPase activity
A3857_RS07770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3857_RS07775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3857_RS07780	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3857_RS07790	COG2890	protein-(glutamine-N5) methyltransferase activity
A3857_RS07795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3857_RS07810	COG0010	Belongs to the arginase family
A3857_RS07815	COG1473	amidohydrolase
A3857_RS07820	COG3956	TIGRFAM MazG family protein
A3857_RS07825	COG1840	ABC-type Fe3 transport system, periplasmic component
A3857_RS07835	COG5002	protein histidine kinase activity
A3857_RS07845	COG0626	cystathionine gamma-synthase activity
A3857_RS07855	COG0194	GDP metabolic process
A3857_RS07860	COG1561	YicC-like family, N-terminal region
A3857_RS07870	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A3857_RS07895	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3857_RS07925	COG2188	Transcriptional regulator
A3857_RS07935	COG1228	amidohydrolase
A3857_RS07940	COG2986	histidine ammonia-lyase
A3857_RS07945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A3857_RS07950	COG1796	DNA polymerase
A3857_RS07950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A3857_RS07955	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
A3857_RS07970	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A3857_RS07975	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A3857_RS07990	COG0018	arginyl-trna synthetase
A3857_RS08010	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A3857_RS08015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A3857_RS08025	COG0583	DNA-binding transcription factor activity
A3857_RS08035	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3857_RS08045	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A3857_RS08060	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A3857_RS08070	COG2354	Protein conserved in bacteria
A3857_RS08115	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A3857_RS08125	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3857_RS08135	COG2814	Major facilitator Superfamily
A3857_RS08140	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A3857_RS08150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3857_RS08155	COG0739	heme binding
A3857_RS08155	COG0741	lytic transglycosylase activity
A3857_RS08155	COG1196	nuclear chromosome segregation
A3857_RS08170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A3857_RS08175	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A3857_RS08180	COG0860	N-Acetylmuramoyl-L-alanine amidase
A3857_RS08185	COG0436	Aminotransferase
A3857_RS08195	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A3857_RS08205	COG0156	8-amino-7-oxononanoate synthase activity
A3857_RS08385	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3857_RS08430	COG2326	polyphosphate kinase activity
A3857_RS08440	COG3842	ATPase activity
A3857_RS08450	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3857_RS08455	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3857_RS08485	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A3857_RS08490	COG0673	inositol 2-dehydrogenase activity
A3857_RS08505	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS08510	COG0427	acetyl-CoA hydrolase
A3857_RS08515	COG5001	Diguanylate cyclase
A3857_RS08605	COG0643	Histidine kinase
A3857_RS08605	COG2198	Histidine kinase
A3857_RS08610	COG2201	protein-glutamate methylesterase activity
A3857_RS08615	COG0840	transmembrane signaling receptor activity
A3857_RS08620	COG1192	Involved in chromosome partitioning
A3857_RS08625	COG0835	chemotaxis
A3857_RS08630	COG2201	protein-glutamate methylesterase activity
A3857_RS08640	COG0643	Histidine kinase
A3857_RS08640	COG2198	Histidine kinase
A3857_RS08655	COG1677	Flagellar hook-basal body complex protein FliE
A3857_RS08720	COG1684	flagellar biosynthetic protein fliR
A3857_RS08725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3857_RS08750	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A3857_RS08750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A3857_RS08780	COG1706	bacterial-type flagellum-dependent cell motility
A3857_RS08790	COG4786	Flagellar basal body rod
A3857_RS08795	COG4786	Flagellar basal body rod
A3857_RS08800	COG1749	Flagellar hook protein flgE
A3857_RS08805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A3857_RS08810	COG1558	bacterial-type flagellum-dependent cell motility
A3857_RS08815	COG1815	bacterial-type flagellum-dependent cell motility
A3857_RS08840	COG3685	Protein conserved in bacteria
A3857_RS08845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3857_RS08850	COG2390	Transcriptional regulator
A3857_RS08860	COG1175	transmembrane transport
A3857_RS08890	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3857_RS08895	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3857_RS08905	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3857_RS08915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3857_RS08915	COG0649	NAD binding
A3857_RS08930	COG1034	ATP synthesis coupled electron transport
A3857_RS08940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3857_RS08945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3857_RS08955	COG0713	ATP synthesis coupled electron transport
A3857_RS08970	COG1007	ATP synthesis coupled electron transport
A3857_RS08975	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3857_RS08985	COG2863	cytochrome
A3857_RS08995	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3857_RS09000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A3857_RS09000	COG2010	Cytochrome c
A3857_RS09005	COG0671	phosphoesterase, PA-phosphatase related
A3857_RS09030	COG3916	Acyl-homoserine-lactone synthase
A3857_RS09040	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3857_RS09050	COG2943	transferase activity, transferring hexosyl groups
A3857_RS09065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3857_RS09070	COG2011	ABC-type metal ion transport system permease component
A3857_RS09075	COG1464	Belongs to the NlpA lipoprotein family
A3857_RS09080	COG1757	Na H antiporter
A3857_RS09145	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3857_RS09145	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3857_RS09165	COG3920	Histidine kinase
A3857_RS09170	COG0784	Response regulator, receiver
A3857_RS09175	COG2205	protein histidine kinase activity
A3857_RS09225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3857_RS09230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3857_RS09250	COG3750	Belongs to the UPF0335 family
A3857_RS09280	COG5002	protein histidine kinase activity
A3857_RS09290	COG0745	RESPONSE REGULATOR receiver
A3857_RS09295	COG1396	sequence-specific DNA binding
A3857_RS09295	COG3800	Transcriptional regulator
A3857_RS09305	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS09310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3857_RS09315	COG0129	dihydroxy-acid dehydratase activity
A3857_RS09320	COG0277	FAD linked oxidase domain protein
A3857_RS09325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3857_RS09330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS09335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS09355	COG1309	transcriptional regulator
A3857_RS09360	COG1309	transcriptional regulator
A3857_RS09385	COG0439	Biotin carboxylase
A3857_RS09390	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A3857_RS09410	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A3857_RS09430	COG4135	transport system, permease component
A3857_RS09435	COG4136	ATPase activity
A3857_RS09440	COG2340	Cysteine-rich secretory protein family
A3857_RS09595	COG1755	Isoprenylcysteine carboxyl methyltransferase
A3857_RS09630	COG0840	transmembrane signaling receptor activity
A3857_RS09645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3857_RS09665	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
A3857_RS09685	COG1376	ErfK ybiS ycfS ynhG family protein
A3857_RS09690	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3857_RS09700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3857_RS09715	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A3857_RS09735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3857_RS09740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS09745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A3857_RS09785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS09790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS09795	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
A3857_RS09800	COG1063	alcohol dehydrogenase
A3857_RS09805	COG0500	methyltransferase
A3857_RS09810	COG0142	geranyltranstransferase activity
A3857_RS09815	COG1233	COG1233 Phytoene dehydrogenase and related
A3857_RS09820	COG5621	secreted hydrolase
A3857_RS09830	COG1562	ergosterol biosynthetic process
A3857_RS09835	COG1233	COG1233 Phytoene dehydrogenase and related
A3857_RS09845	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A3857_RS09850	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
A3857_RS09865	COG0644	oxidoreductase
A3857_RS09870	COG2211	Major facilitator Superfamily
A3857_RS09875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3857_RS09880	COG1719	4-vinyl reductase, 4VR
A3857_RS09885	COG1032	radical SAM domain protein
A3857_RS09905	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS09910	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS09915	COG1429	ligase activity, forming nitrogen-metal bonds
A3857_RS09955	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A3857_RS09965	COG3474	cytochrome
A3857_RS09980	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS09995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
A3857_RS10000	COG0830	nickel cation binding
A3857_RS10005	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
A3857_RS10015	COG0804	urea catabolic process
A3857_RS10040	COG0829	nickel cation binding
A3857_RS10070	COG2814	Major facilitator Superfamily
A3857_RS10075	COG2197	response regulator
A3857_RS10080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3857_RS10105	COG0714	Associated with various cellular activities
A3857_RS10110	COG3256	nitric oxide reductase
A3857_RS10115	COG2010	Cytochrome c
A3857_RS10185	COG2264	protein methyltransferase activity
A3857_RS10195	COG0402	S-adenosylhomocysteine deaminase activity
A3857_RS10200	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3857_RS10205	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3857_RS10210	COG3845	ABC transporter
A3857_RS10235	COG3842	ATPase activity
A3857_RS10255	COG0587	DNA-directed DNA polymerase activity
A3857_RS10270	COG0330	HflC and HflK could
A3857_RS10275	COG0330	HflC and HflK could
A3857_RS10285	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3857_RS10295	COG1760	l-serine dehydratase
A3857_RS10300	COG0697	spore germination
A3857_RS10320	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3857_RS10335	COG0504	CTP synthase activity
A3857_RS10365	COG4160	amino acid transport
A3857_RS10370	COG0174	glutamine synthetase
A3857_RS10375	COG0519	Catalyzes the synthesis of GMP from XMP
A3857_RS10380	COG0174	glutamine synthetase
A3857_RS10385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS10390	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3857_RS10405	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3857_RS10420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3857_RS10425	COG1278	Cold shock
A3857_RS10445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A3857_RS10455	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3857_RS10455	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3857_RS10470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A3857_RS10475	COG0358	DNA primase activity
A3857_RS10480	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3857_RS10525	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A3857_RS10535	COG3706	GGDEF domain
A3857_RS10540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3857_RS10565	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A3857_RS10570	COG0546	phosphoglycolate phosphatase activity
A3857_RS10580	COG3706	GGDEF domain
A3857_RS10630	COG0667	Aldo Keto reductase
A3857_RS10640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3857_RS10670	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3857_RS10675	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3857_RS10690	COG0719	Fe-S assembly protein
A3857_RS10695	COG0396	ATPase activity
A3857_RS10705	COG0719	Fe-S assembly protein
A3857_RS10720	COG2945	thiolester hydrolase activity
A3857_RS10730	COG0538	isocitrate dehydrogenase activity
A3857_RS10745	COG1217	gtp-binding protein TYPA
A3857_RS10750	COG0121	glutamine amidotransferase
A3857_RS10760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3857_RS10780	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3857_RS10780	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3857_RS10795	COG5642	Protein of unknown function (DUF2384)
A3857_RS10815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3857_RS10825	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3857_RS10830	COG0826	peptidase U32
A3857_RS10835	COG0826	peptidase U32
A3857_RS10845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A3857_RS10855	COG0579	oxidoreductase
A3857_RS10875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A3857_RS10880	COG3909	cytochrome
A3857_RS10890	COG0235	Class ii aldolase
A3857_RS10915	COG0246	Mannitol dehydrogenase
A3857_RS10920	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS10930	COG1917	Cupin 2, conserved barrel domain protein
A3857_RS10945	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3857_RS10950	COG1904	glucuronate isomerase
A3857_RS10955	COG1802	Transcriptional regulator
A3857_RS10995	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A3857_RS11045	COG0375	protein maturation
A3857_RS11080	COG2197	response regulator
A3857_RS11085	COG4191	Histidine kinase
A3857_RS11095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3857_RS11120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3857_RS11135	COG0673	inositol 2-dehydrogenase activity
A3857_RS11140	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A3857_RS11150	COG1272	protein, Hemolysin III
A3857_RS11220	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS11225	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
A3857_RS11255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3857_RS11280	COG1686	Belongs to the peptidase S11 family
A3857_RS11295	COG2076	Multidrug Resistance protein
A3857_RS11305	COG0501	Belongs to the peptidase M48B family
A3857_RS11330	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A3857_RS11350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A3857_RS11360	COG1183	phosphatidylcholine synthase activity
A3857_RS11370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3857_RS11380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A3857_RS11385	COG3768	UPF0283 membrane protein
A3857_RS11390	COG3106	COG3106 Predicted ATPase
A3857_RS11395	COG0101	tRNA pseudouridine synthase activity
A3857_RS11400	COG5002	protein histidine kinase activity
A3857_RS11400	COG2176	DNA-directed DNA polymerase activity
A3857_RS11405	COG0745	RESPONSE REGULATOR receiver
A3857_RS11415	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A3857_RS11420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3857_RS11435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A3857_RS11440	COG0659	secondary active sulfate transmembrane transporter activity
A3857_RS11460	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3857_RS11465	COG1764	response to oxidative stress
A3857_RS11475	COG0488	(ABC) transporter
A3857_RS11500	COG1278	Cold shock
A3857_RS11510	COG3119	arylsulfatase activity
A3857_RS11525	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3857_RS11530	COG0756	dUTP diphosphatase activity
A3857_RS11535	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A3857_RS11565	COG1203	CRISPR-associated helicase, Cas3
A3857_RS11570	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3857_RS11575	COG1595	DNA-templated transcription, initiation
A3857_RS11590	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS11595	COG1733	regulation of RNA biosynthetic process
A3857_RS11645	COG0514	ATP-dependent DNA helicase (RecQ)
A3857_RS11655	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A3857_RS11660	COG1530	ribonuclease E activity
A3857_RS11665	COG0424	maF-like protein
A3857_RS11675	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3857_RS11675	COG3153	acetyltransferase
A3857_RS11690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3857_RS11695	COG5328	Belongs to the UPF0262 family
A3857_RS11700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A3857_RS11710	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A3857_RS11745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS11760	COG1396	sequence-specific DNA binding
A3857_RS11775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS11780	COG1116	anion transmembrane transporter activity
A3857_RS11785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3857_RS11790	COG0351	phosphomethylpyrimidine kinase
A3857_RS11795	COG0352	thiamine-phosphate diphosphorylase activity
A3857_RS11800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3857_RS11805	COG0741	lytic transglycosylase activity
A3857_RS11805	COG0739	heme binding
A3857_RS11805	COG1196	nuclear chromosome segregation
A3857_RS11815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A3857_RS11820	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3857_RS11830	COG0217	transcriptional regulatory protein
A3857_RS11835	COG3273	potassium ion transport
A3857_RS11835	COG0471	metal ion transport
A3857_RS11840	COG1692	metallophosphoesterase
A3857_RS11845	COG1201	RNA secondary structure unwinding
A3857_RS11860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A3857_RS11880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3857_RS11885	COG0037	tRNA processing
A3857_RS11895	COG2885	chlorophyll binding
A3857_RS11910	COG0848	biopolymer transport protein
A3857_RS11920	COG0824	Thioesterase
A3857_RS11935	COG0084	hydrolase, TatD family'
A3857_RS11960	COG0181	hydroxymethylbilane synthase activity
A3857_RS11965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A3857_RS11975	COG0408	coproporphyrinogen oxidase activity
A3857_RS11985	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS11995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A3857_RS12005	COG1686	Belongs to the peptidase S11 family
A3857_RS12025	COG0348	domain, Protein
A3857_RS12030	COG2010	Cytochrome c
A3857_RS12055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3857_RS12060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3857_RS12065	COG0438	transferase activity, transferring glycosyl groups
A3857_RS12070	COG4172	Belongs to the ABC transporter superfamily
A3857_RS12075	COG4239	(ABC) transporter, permease
A3857_RS12080	COG4174	ABC transporter (Permease)
A3857_RS12125	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A3857_RS12165	COG0688	phosphatidylethanolamine metabolic process
A3857_RS12170	COG1183	phosphatidylcholine synthase activity
A3857_RS12180	COG1522	sequence-specific DNA binding
A3857_RS12185	COG0686	Belongs to the AlaDH PNT family
A3857_RS12190	COG1970	mechanosensitive ion channel activity
A3857_RS12195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A3857_RS12200	COG0165	Argininosuccinate lyase
A3857_RS12220	COG0019	diaminopimelate decarboxylase activity
A3857_RS12235	COG2884	Cell division ATP-binding protein ftsE
A3857_RS12255	COG1763	Mo-molybdopterin cofactor biosynthetic process
A3857_RS12260	COG0746	molybdenum cofactor guanylyltransferase activity
A3857_RS12290	COG1960	acyl-CoA dehydrogenase activity
A3857_RS12295	COG0009	L-threonylcarbamoyladenylate synthase
A3857_RS12300	COG2818	Glycosylase
A3857_RS12330	COG0142	geranyltranstransferase activity
A3857_RS12370	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3857_RS12375	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3857_RS12380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3857_RS12380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3857_RS12400	COG1596	polysaccharide export
A3857_RS12405	COG1846	Transcriptional regulator
A3857_RS12425	COG0534	Mate efflux family protein
A3857_RS12435	COG2326	polyphosphate kinase activity
A3857_RS12450	COG0187	DNA topoisomerase II activity
A3857_RS12455	COG1312	Catalyzes the dehydration of D-mannonate
A3857_RS12470	COG1136	(ABC) transporter
A3857_RS12475	COG4591	ABC-type transport system involved in lipoprotein release permease component
A3857_RS12480	COG0442	prolyl-tRNA aminoacylation
A3857_RS12485	COG0628	permease
A3857_RS12495	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A3857_RS12500	COG0248	Ppx GppA phosphatase
A3857_RS12510	COG1247	-acetyltransferase
A3857_RS12515	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A3857_RS12540	COG0535	radical SAM domain protein
A3857_RS12550	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
A3857_RS12555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3857_RS12575	COG1492	cobalamin metabolic process
A3857_RS12585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3857_RS12595	COG1234	tRNA 3'-trailer cleavage
A3857_RS12600	COG1872	DUF167
A3857_RS12615	COG4608	Belongs to the ABC transporter superfamily
A3857_RS12620	COG0444	Belongs to the ABC transporter superfamily
A3857_RS12625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS12630	COG0601	transmembrane transport
A3857_RS12635	COG0747	negative chemotaxis
A3857_RS12655	COG0346	lactoylglutathione lyase activity
A3857_RS12685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A3857_RS12695	COG0513	Belongs to the DEAD box helicase family
A3857_RS12710	COG0596	Alpha beta hydrolase
A3857_RS12720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3857_RS12725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3857_RS12730	COG0193	aminoacyl-tRNA hydrolase activity
A3857_RS12755	COG0617	tRNA 3'-terminal CCA addition
A3857_RS12755	COG3620	sequence-specific DNA binding
A3857_RS12755	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A3857_RS12765	COG0012	GTP binding
A3857_RS12770	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
A3857_RS12770	COG0662	Cupin 2, conserved barrel domain protein
A3857_RS12805	COG0495	leucyl-tRNA aminoacylation
A3857_RS12840	COG0745	RESPONSE REGULATOR receiver
A3857_RS12865	COG0679	Auxin Efflux Carrier
A3857_RS12870	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
A3857_RS12875	COG1671	Belongs to the UPF0178 family
A3857_RS12880	COG2423	ornithine cyclodeaminase activity
A3857_RS12900	COG4106	trans-aconitate 2-methyltransferase activity
A3857_RS12910	COG0697	spore germination
A3857_RS12915	COG0473	3-isopropylmalate dehydrogenase activity
A3857_RS12940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3857_RS12955	COG0799	negative regulation of ribosome biogenesis
A3857_RS12960	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A3857_RS12985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A3857_RS12990	COG0242	peptide deformylase activity
A3857_RS12995	COG0242	peptide deformylase activity
A3857_RS13000	COG0242	peptide deformylase activity
A3857_RS13005	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A3857_RS13025	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS13025	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A3857_RS13035	COG0741	lytic transglycosylase activity
A3857_RS13040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3857_RS13050	COG2897	thiosulfate sulfurtransferase activity
A3857_RS13060	COG0004	ammonium transporteR
A3857_RS13065	COG0347	Belongs to the P(II) protein family
A3857_RS13080	COG2853	Lipoprotein
A3857_RS13090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3857_RS13115	COG2154	pterin-4-alpha-carbinolamine dehydratase
A3857_RS13120	COG0678	peroxiredoxin activity
A3857_RS13130	COG0742	ribosomal rna small subunit methyltransferase
A3857_RS13135	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3857_RS13145	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3857_RS13150	COG1121	(ABC) transporter
A3857_RS13155	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3857_RS13160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3857_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS13205	COG0312	modulator of DNA gyrase
A3857_RS13220	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS13235	COG0848	biopolymer transport protein
A3857_RS13245	COG0024	Methionine aminopeptidase
A3857_RS13250	COG1058	Belongs to the CinA family
A3857_RS13250	COG1546	Belongs to the CinA family
A3857_RS13265	COG0583	DNA-binding transcription factor activity
A3857_RS13280	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A3857_RS13285	COG0285	dihydrofolate synthase activity
A3857_RS13295	COG0793	Belongs to the peptidase S41A family
A3857_RS13305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3857_RS13310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3857_RS13315	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A3857_RS13345	COG1116	anion transmembrane transporter activity
A3857_RS13355	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3857_RS13385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
A3857_RS13390	COG1877	trehalose-phosphatase activity
A3857_RS13395	COG4187	Peptidase family M20/M25/M40
A3857_RS13420	COG0737	Belongs to the 5'-nucleotidase family
A3857_RS13430	COG0167	dihydroorotate dehydrogenase activity
A3857_RS13445	COG0604	alcohol dehydrogenase
A3857_RS13450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3857_RS13450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3857_RS13465	COG0508	dehydrogenase complex catalyzes the overall conversion of
A3857_RS13470	COG0567	Dehydrogenase, E1 component
A3857_RS13495	COG2301	Belongs to the HpcH HpaI aldolase family
A3857_RS13510	COG2030	dehydratase
A3857_RS13550	COG1802	Transcriptional regulator
A3857_RS13575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A3857_RS13585	COG1072	(Pantothenic acid kinase))
A3857_RS13610	COG2111	Na H antiporter
A3857_RS13610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3857_RS13615	COG1006	Multisubunit Na H antiporter MnhC subunit
A3857_RS13620	COG0651	ATP synthesis coupled electron transport
A3857_RS13625	COG1863	multisubunit Na H antiporter MnhE subunit
A3857_RS13630	COG2212	antiporter activity
A3857_RS13635	COG1320	monovalent cation:proton antiporter activity
A3857_RS13645	COG1678	Uncharacterized ACR, COG1678
A3857_RS13655	COG1573	uracil-dna glycosylase
A3857_RS13690	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3857_RS13715	COG1253	flavin adenine dinucleotide binding
A3857_RS13725	COG2304	oxidoreductase activity
A3857_RS13730	COG0071	Belongs to the small heat shock protein (HSP20) family
A3857_RS13740	COG0247	lactate metabolic process
A3857_RS13745	COG0277	FAD linked oxidase domain protein
A3857_RS13750	COG0277	FAD linked oxidase domain protein
A3857_RS13775	COG0714	Associated with various cellular activities
A3857_RS13795	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3857_RS13795	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A3857_RS13805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3857_RS13810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3857_RS13815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3857_RS13820	COG2885	chlorophyll binding
A3857_RS13830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3857_RS13840	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A3857_RS13855	COG0640	Transcriptional regulator
A3857_RS13860	COG0318	PFAM AMP-dependent synthetase and ligase
A3857_RS13865	COG1192	Involved in chromosome partitioning
A3857_RS13880	COG0336	Belongs to the RNA methyltransferase TrmD family
A3857_RS13890	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A3857_RS13920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3857_RS13940	COG3852	Histidine kinase
A3857_RS13960	COG0594	ribonuclease P activity
A3857_RS13970	COG0037	tRNA processing
A3857_RS13980	COG0706	membrane insertase activity
A3857_RS13990	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3857_RS13995	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS14015	COG0314	molybdopterin synthase activity
A3857_RS14025	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3857_RS14030	COG0322	excinuclease ABC activity
A3857_RS14040	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS14050	COG0616	signal peptide processing
A3857_RS14050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A3857_RS14070	COG3383	formate dehydrogenase (NAD+) activity
A3857_RS14075	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A3857_RS14090	COG0297	glycogen (starch) synthase activity
A3857_RS14090	COG0438	transferase activity, transferring glycosyl groups
A3857_RS14095	COG0745	RESPONSE REGULATOR receiver
A3857_RS14120	COG4221	oxidoreductase activity
A3857_RS14145	COG1595	DNA-templated transcription, initiation
A3857_RS14150	COG3806	Anti-sigma factor
A3857_RS14160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A3857_RS14165	COG0612	Peptidase, M16
A3857_RS14170	COG0612	Peptidase, M16
A3857_RS14180	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A3857_RS14205	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A3857_RS14210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A3857_RS14220	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3857_RS14260	COG0438	transferase activity, transferring glycosyl groups
A3857_RS14295	COG0587	DNA-directed DNA polymerase activity
A3857_RS14300	COG2951	lytic endotransglycosylase activity
A3857_RS14305	COG0557	exoribonuclease II activity
A3857_RS14310	COG2153	protein acetylation
A3857_RS14315	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3857_RS14325	COG2323	membrane
A3857_RS14330	COG2171	N-acyltransferase activity
A3857_RS14345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A3857_RS14350	COG0142	geranyltranstransferase activity
A3857_RS14355	COG1722	exodeoxyribonuclease VII activity
A3857_RS14360	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3857_RS14365	COG0745	RESPONSE REGULATOR receiver
A3857_RS14370	COG1846	Transcriptional regulator
A3857_RS14375	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3857_RS14390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3857_RS14400	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A3857_RS14460	COG1137	ATPase activity
A3857_RS14465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A3857_RS14470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A3857_RS14480	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A3857_RS14485	COG1218	3'(2'),5'-bisphosphate nucleotidase
A3857_RS14490	COG0779	Required for maturation of 30S ribosomal subunits
A3857_RS14505	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3857_RS14515	COG0494	nUDIX hydrolase
A3857_RS14520	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A3857_RS14525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A3857_RS14530	COG0653	protein targeting
A3857_RS14540	COG2003	Belongs to the UPF0758 family
A3857_RS14545	COG0484	heat shock protein binding
A3857_RS14550	COG0443	Heat shock 70 kDa protein
A3857_RS14560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A3857_RS14565	COG2115	Belongs to the xylose isomerase family
A3857_RS14570	COG1070	Carbohydrate kinase
A3857_RS14575	COG1129	ABC transporter
A3857_RS14580	COG4214	carbohydrate transport
A3857_RS14585	COG4213	ABC transporter substrate-binding protein
A3857_RS14590	COG1940	carbohydrate kinase activity
A3857_RS14595	COG0729	surface antigen
A3857_RS14600	COG2911	Protein conserved in bacteria
A3857_RS14605	COG1295	ribonuclease BN
A3857_RS14620	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3857_RS14630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A3857_RS14645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A3857_RS14650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A3857_RS14655	COG1040	competence protein
A3857_RS14685	COG3034	peptidoglycan biosynthetic process
A3857_RS14690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3857_RS14695	COG1132	(ABC) transporter
A3857_RS14700	COG1132	(ABC) transporter
A3857_RS14705	COG0617	tRNA 3'-terminal CCA addition
A3857_RS14710	COG0494	nUDIX hydrolase
A3857_RS14725	COG0745	RESPONSE REGULATOR receiver
A3857_RS14765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3857_RS14765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3857_RS14770	COG0280	phosphate acetyltransferase
A3857_RS14770	COG0281	malic enzyme
A3857_RS14775	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3857_RS14780	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A3857_RS14785	COG1420	regulation of RNA biosynthetic process
A3857_RS14795	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3857_RS14800	COG0251	oxidation-reduction process
A3857_RS14805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3857_RS14810	COG2832	Protein of unknown function (DUF454)
A3857_RS14825	COG0357	Ribosomal RNA small subunit methyltransferase G
A3857_RS14830	COG0445	tRNA wobble uridine modification
A3857_RS14835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A3857_RS14840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A3857_RS14845	COG1981	membrane
A3857_RS14850	COG0424	maF-like protein
A3857_RS14855	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3857_RS14860	COG0237	dephospho-CoA kinase activity
A3857_RS14865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A3857_RS14890	COG2840	Smr protein MutS2
A3857_RS14900	COG1609	Transcriptional regulator
A3857_RS14910	COG0673	inositol 2-dehydrogenase activity
A3857_RS14915	COG1129	ABC transporter
A3857_RS14920	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS14925	COG1879	ABC-type sugar transport system periplasmic component
A3857_RS14955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A3857_RS14965	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3857_RS14970	COG3243	poly(R)-hydroxyalkanoic acid synthase
A3857_RS14975	COG2267	carboxylic ester hydrolase activity
A3857_RS14990	COG2200	EAL domain
A3857_RS15010	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
A3857_RS15020	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A3857_RS15025	COG2205	protein histidine kinase activity
A3857_RS15030	COG0745	RESPONSE REGULATOR receiver
A3857_RS15035	COG3237	CsbD-like
A3857_RS15055	COG0784	Response regulator, receiver
A3857_RS15065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3857_RS15080	COG0546	phosphoglycolate phosphatase activity
A3857_RS15115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A3857_RS15155	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS15165	COG0022	dehydrogenase e1 component
A3857_RS15170	COG1960	acyl-CoA dehydrogenase activity
A3857_RS15175	COG0583	DNA-binding transcription factor activity
A3857_RS15180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A3857_RS15210	COG1749	Flagellar hook protein flgE
A3857_RS15225	COG1706	bacterial-type flagellum-dependent cell motility
A3857_RS15230	COG4191	Histidine kinase
A3857_RS15230	COG0784	Response regulator, receiver
A3857_RS15240	COG1338	Plays a role in the flagellum-specific transport system
A3857_RS15245	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A3857_RS15255	COG1766	The M ring may be actively involved in energy transduction
A3857_RS15275	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A3857_RS15290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3857_RS15300	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A3857_RS15315	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
A3857_RS15325	COG4786	Flagellar basal body rod
A3857_RS15330	COG4786	Flagellar basal body rod
A3857_RS15335	COG1987	bacterial-type flagellum assembly
A3857_RS15340	COG1677	Flagellar hook-basal body complex protein FliE
A3857_RS15345	COG1558	bacterial-type flagellum-dependent cell motility
A3857_RS15350	COG1815	bacterial-type flagellum-dependent cell motility
A3857_RS15375	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A3857_RS15390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A3857_RS15415	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3857_RS15435	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
A3857_RS15440	COG0560	Phosphoserine phosphatase
A3857_RS15445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A3857_RS15450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3857_RS15460	COG0183	Belongs to the thiolase family
A3857_RS15465	COG4953	penicillin-binding protein 1C
A3857_RS15470	COG2373	Large extracellular alpha-helical protein
A3857_RS15475	COG2205	protein histidine kinase activity
A3857_RS15475	COG5002	protein histidine kinase activity
A3857_RS15475	COG0784	Response regulator, receiver
A3857_RS15480	COG3022	response to hydroperoxide
A3857_RS15485	COG0514	ATP-dependent DNA helicase (RecQ)
A3857_RS15505	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
A3857_RS15515	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A3857_RS15525	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A3857_RS15530	COG1335	isochorismatase
A3857_RS15535	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS15540	COG3734	2-keto-3-deoxy-galactonokinase
A3857_RS15545	COG0366	Alpha amylase catalytic
A3857_RS15550	COG2271	Major facilitator Superfamily
A3857_RS15560	COG0438	transferase activity, transferring glycosyl groups
A3857_RS15575	COG0288	reversible hydration of carbon dioxide
A3857_RS15585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A3857_RS15590	COG0791	NLP P60 protein
A3857_RS15595	COG3214	Protein conserved in bacteria
A3857_RS15620	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A3857_RS15650	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
A3857_RS15670	COG0625	glutathione transferase activity
A3857_RS15695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A3857_RS15715	COG0284	orotidine-5'-phosphate decarboxylase activity
A3857_RS15720	COG1940	carbohydrate kinase activity
A3857_RS15730	COG0542	response to heat
A3857_RS15735	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
A3857_RS15740	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A3857_RS15800	COG3609	addiction module antidote protein, CC2985 family
A3857_RS15865	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A3857_RS15870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A3857_RS15895	COG0352	thiamine-phosphate diphosphorylase activity
A3857_RS15910	COG1612	heme a metabolic process
A3857_RS15915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3857_RS15950	COG1228	amidohydrolase
A3857_RS16030	COG3246	L-lysine catabolic process to acetate
A3857_RS16040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3857_RS16045	COG1960	acyl-CoA dehydrogenase activity
A3857_RS16075	COG2249	NAD(P)H dehydrogenase (quinone) activity
A3857_RS16085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3857_RS16090	COG0348	domain, Protein
A3857_RS16095	COG0156	8-amino-7-oxononanoate synthase activity
A3857_RS16105	COG0601	transmembrane transport
A3857_RS16110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS16115	COG0444	Belongs to the ABC transporter superfamily
A3857_RS16130	COG2814	Major facilitator Superfamily
A3857_RS16145	COG1177	transmembrane transport
A3857_RS16160	COG3842	ATPase activity
A3857_RS16185	COG3005	denitrification pathway
A3857_RS16200	COG0303	'Molybdopterin
A3857_RS16220	COG0346	lactoylglutathione lyase activity
A3857_RS16225	COG0400	carboxylic ester hydrolase activity
A3857_RS16245	COG4175	Glycine betaine
A3857_RS16245	COG3448	diguanylate cyclase activity
A3857_RS16250	COG4176	ABC-type proline glycine betaine transport system permease component
A3857_RS16275	COG0318	PFAM AMP-dependent synthetase and ligase
A3857_RS16280	COG1349	DNA-binding transcription factor activity
A3857_RS16290	COG2223	nitrite transmembrane transporter activity
A3857_RS16305	COG0431	NADPH-dependent FMN reductase
A3857_RS16315	COG0702	epimerase
A3857_RS16335	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3857_RS16340	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
A3857_RS16345	COG3046	protein related to deoxyribodipyrimidine photolyase
A3857_RS16355	COG4607	ABC-type enterochelin transport system periplasmic component
A3857_RS16360	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A3857_RS16365	COG1132	(ABC) transporter
A3857_RS16375	COG0840	transmembrane signaling receptor activity
A3857_RS16385	COG2194	sulfuric ester hydrolase activity
A3857_RS16395	COG0642	Histidine kinase
A3857_RS16410	COG2824	Alkylphosphonate utilization operon protein PhnA
A3857_RS16425	COG0670	Belongs to the BI1 family
A3857_RS16435	COG1595	DNA-templated transcription, initiation
A3857_RS16445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3857_RS16450	COG2010	Cytochrome c
A3857_RS16450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A3857_RS16465	COG5001	Diguanylate cyclase
A3857_RS16475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A3857_RS16495	COG3920	Histidine kinase
A3857_RS16515	COG0840	transmembrane signaling receptor activity
A3857_RS16540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS16555	COG0628	permease
A3857_RS16565	COG3443	Belongs to the bacterial solute-binding protein 9 family
A3857_RS16590	COG0435	Glutathione S-transferase
A3857_RS16595	COG3384	dioxygenase
A3857_RS16610	COG0798	PFAM Bile acid sodium symporter
A3857_RS16630	COG3266	domain, Protein
A3857_RS16630	COG0515	serine threonine protein kinase
A3857_RS16635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3857_RS16650	COG1262	PFAM Formylglycine-generating sulfatase enzyme
A3857_RS16675	COG4529	Protein conserved in bacteria
A3857_RS16680	COG3386	PFAM SMP-30 Gluconolaconase
A3857_RS16700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3857_RS16710	COG2855	membrane
A3857_RS16725	COG1053	succinate dehydrogenase
A3857_RS16740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A3857_RS16755	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS16760	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
A3857_RS16765	COG0028	Belongs to the TPP enzyme family
A3857_RS16770	COG0583	DNA-binding transcription factor activity
A3857_RS16780	COG0842	Transport permease protein
A3857_RS16785	COG0842	Transport permease protein
A3857_RS16785	COG1129	ABC transporter
A3857_RS16790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3857_RS16795	COG0392	lysyltransferase activity
A3857_RS16825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A3857_RS16830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A3857_RS16830	COG1116	anion transmembrane transporter activity
A3857_RS16845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3857_RS16850	COG2084	Dehydrogenase
A3857_RS16855	COG0730	response to heat
A3857_RS16860	COG1953	Uracil, thiamine, allantoin
A3857_RS16870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3857_RS16880	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A3857_RS16895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
A3857_RS16900	COG1960	acyl-CoA dehydrogenase activity
A3857_RS16910	COG0183	Belongs to the thiolase family
A3857_RS16915	COG1797	cobyrinic acid a,c-diamide synthase activity
A3857_RS16930	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
A3857_RS16945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3857_RS16950	COG0633	Ferredoxin
A3857_RS16955	COG0426	domain, Protein
A3857_RS16965	COG2878	Part of a membrane complex involved in electron transport
A3857_RS16970	COG4656	Part of a membrane complex involved in electron transport
A3857_RS16980	COG4659	FMN binding
A3857_RS16990	COG2914	Belongs to the UPF0125 (RnfH) family
A3857_RS17000	COG0443	Heat shock 70 kDa protein
A3857_RS17005	COG0667	Aldo Keto reductase
A3857_RS17010	COG2207	Transcriptional regulator
A3857_RS17020	COG2080	2 iron, 2 sulfur cluster binding
A3857_RS17025	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A3857_RS17030	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A3857_RS17040	COG0310	cobalt ion transport
A3857_RS17060	COG1294	oxidase, subunit
A3857_RS17065	COG1271	oxidase subunit
A3857_RS17080	COG4717	serine-type aminopeptidase activity
A3857_RS17085	COG0420	3'-5' exonuclease activity
A3857_RS17090	COG0778	Nitroreductase
A3857_RS17105	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3857_RS17110	COG4605	iron ion homeostasis
A3857_RS17115	COG4604	ABC transporter, ATP-binding protein
A3857_RS17120	COG4771	TonB-dependent receptor
A3857_RS17130	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3857_RS17135	COG1509	lysine 2,3-aminomutase activity
A3857_RS17145	COG2951	lytic endotransglycosylase activity
A3857_RS17155	COG0747	negative chemotaxis
A3857_RS17160	COG0601	transmembrane transport
A3857_RS17165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS17170	COG0444	Belongs to the ABC transporter superfamily
A3857_RS17175	COG4608	Belongs to the ABC transporter superfamily
A3857_RS17215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A3857_RS17225	COG4172	Belongs to the ABC transporter superfamily
A3857_RS17230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS17235	COG0601	transmembrane transport
A3857_RS17250	COG0747	negative chemotaxis
A3857_RS17255	COG0601	transmembrane transport
A3857_RS17260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS17275	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3857_RS17290	COG2010	Cytochrome c
A3857_RS17330	COG1850	ribulose-bisphosphate carboxylase activity
A3857_RS17335	COG0405	Gamma-glutamyltransferase
A3857_RS17340	COG0842	Transport permease protein
A3857_RS17345	COG1131	(ABC) transporter
A3857_RS17350	COG0714	Associated with various cellular activities
A3857_RS17385	COG0673	inositol 2-dehydrogenase activity
A3857_RS17390	COG3962	Belongs to the TPP enzyme family
A3857_RS17400	COG3718	enzyme involved in inositol metabolism
A3857_RS17405	COG3842	ATPase activity
A3857_RS17410	COG0395	ABC-type sugar transport system, permease component
A3857_RS17415	COG1175	transmembrane transport
A3857_RS17420	COG1653	transport
A3857_RS17425	COG1283	sodium-dependent phosphate transmembrane transporter activity
A3857_RS17480	COG0800	Aldolase
A3857_RS17485	COG0745	RESPONSE REGULATOR receiver
A3857_RS17490	COG0840	transmembrane signaling receptor activity
A3857_RS17500	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
A3857_RS17520	COG0697	spore germination
A3857_RS17540	COG2801	Transposase and inactivated derivatives
A3857_RS17600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A3857_RS17605	COG3284	Transcriptional regulator
A3857_RS17615	COG2909	trisaccharide binding
A3857_RS17620	COG2244	polysaccharide biosynthetic process
A3857_RS17625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3857_RS17655	COG0471	metal ion transport
A3857_RS17655	COG3273	potassium ion transport
A3857_RS17665	COG1346	cytolysis
A3857_RS17695	COG3842	ATPase activity
A3857_RS17710	COG2962	Rard protein
A3857_RS17725	COG3706	GGDEF domain
A3857_RS17830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3857_RS17850	COG3706	GGDEF domain
A3857_RS17860	COG0154	amidase activity
A3857_RS17875	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
A3857_RS17880	COG1136	(ABC) transporter
A3857_RS17880	COG0577	efflux transmembrane transporter activity
A3857_RS17885	COG0577	efflux transmembrane transporter activity
A3857_RS17885	COG1136	(ABC) transporter
A3857_RS17895	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A3857_RS17935	COG4948	Mandelate Racemase Muconate Lactonizing
A3857_RS17940	COG0583	DNA-binding transcription factor activity
A3857_RS17960	COG0473	3-isopropylmalate dehydrogenase activity
A3857_RS17965	COG1120	ATPase activity
A3857_RS17970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3857_RS17980	COG1177	transmembrane transport
A3857_RS17985	COG1176	ABC-type spermidine putrescine transport system, permease component I
A3857_RS17990	COG3842	ATPase activity
A3857_RS17995	COG1840	ABC-type Fe3 transport system, periplasmic component
A3857_RS18000	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3857_RS18010	COG0583	DNA-binding transcription factor activity
A3857_RS18030	COG3395	kinase activity
A3857_RS18040	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A3857_RS18050	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3857_RS18070	COG1454	alcohol dehydrogenase
A3857_RS18075	COG1120	ATPase activity
A3857_RS18080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3857_RS18085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3857_RS18095	COG4774	siderophore transport
A3857_RS18115	COG0840	transmembrane signaling receptor activity
A3857_RS18130	COG0708	Exodeoxyribonuclease III
A3857_RS18145	COG0754	glutathionylspermidine amidase activity
A3857_RS18170	COG0642	Histidine kinase
A3857_RS18175	COG0840	transmembrane signaling receptor activity
A3857_RS18195	COG0583	DNA-binding transcription factor activity
A3857_RS18210	COG0436	Aminotransferase
A3857_RS18215	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS18220	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3857_RS18225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A3857_RS18235	COG0006	proline dipeptidase activity
A3857_RS18240	COG1802	Transcriptional regulator
A3857_RS18255	COG1802	Transcriptional regulator
A3857_RS18260	COG1984	allophanate hydrolase subunit 2
A3857_RS18265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3857_RS18280	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3857_RS18290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A3857_RS18310	COG0765	amino acid transport
A3857_RS18315	COG0765	amino acid transport
A3857_RS18340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3857_RS18470	COG0631	protein serine/threonine phosphatase activity
A3857_RS18515	COG3347	Dehydrogenase
A3857_RS18515	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS18530	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS18540	COG2390	Transcriptional regulator
A3857_RS18575	COG2205	protein histidine kinase activity
A3857_RS18585	COG3706	GGDEF domain
A3857_RS18600	COG3842	ATPase activity
A3857_RS18610	COG1177	transmembrane transport
A3857_RS18615	COG3938	Belongs to the proline racemase family
A3857_RS18625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3857_RS18630	COG0601	transmembrane transport
A3857_RS18635	COG0747	negative chemotaxis
A3857_RS18640	COG0747	negative chemotaxis
A3857_RS18675	COG0318	PFAM AMP-dependent synthetase and ligase
A3857_RS18680	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS18685	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3857_RS18700	COG2130	NADP-dependent
A3857_RS18800	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3857_RS18815	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3857_RS18835	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3857_RS18840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3857_RS18845	COG1121	(ABC) transporter
A3857_RS18855	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
A3857_RS18870	COG2986	histidine ammonia-lyase
A3857_RS18945	COG0133	tryptophan synthase activity
A3857_RS18955	COG0135	phosphoribosylanthranilate isomerase activity
A3857_RS18965	COG0776	regulation of translation
A3857_RS18970	COG0539	negative regulation of cytoplasmic translation
A3857_RS18975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3857_RS18980	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A3857_RS18985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3857_RS19000	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A3857_RS19005	COG4535	Mg2 and Co2 transporter CorC
A3857_RS19010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A3857_RS19015	COG1702	phosphate starvation-inducible protein PhoH
A3857_RS19020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3857_RS19030	COG4181	ATPase activity
A3857_RS19035	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
A3857_RS19045	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A3857_RS19080	COG3750	Belongs to the UPF0335 family
A3857_RS19135	COG3459	Glycosyltransferase 36 associated
A3857_RS19150	COG0459	protein refolding
A3857_RS19210	COG1278	Cold shock
A3857_RS19215	COG1278	Cold shock
A3857_RS19330	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3857_RS19340	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A3857_RS19410	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3857_RS19420	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
A3857_RS19435	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3857_RS19440	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3857_RS19445	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A3857_RS19450	COG2186	Transcriptional regulator
A3857_RS19460	COG2197	response regulator
A3857_RS19490	COG1175	transmembrane transport
A3857_RS19505	COG1802	Transcriptional regulator
A3857_RS19510	COG3842	ATPase activity
A3857_RS19530	COG1902	pentaerythritol trinitrate reductase activity
A3857_RS19530	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3857_RS19565	COG1879	ABC-type sugar transport system periplasmic component
A3857_RS19575	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS19590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3857_RS19605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3857_RS19610	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3857_RS19625	COG4208	sulfate ABC transporter
A3857_RS19645	COG4214	carbohydrate transport
A3857_RS19665	COG1252	NADH dehydrogenase
A3857_RS19670	COG0840	transmembrane signaling receptor activity
A3857_RS19680	COG2212	antiporter activity
A3857_RS19685	COG1863	multisubunit Na H antiporter MnhE subunit
A3857_RS19690	COG0651	ATP synthesis coupled electron transport
A3857_RS19695	COG1006	Multisubunit Na H antiporter MnhC subunit
A3857_RS19700	COG2111	Na H antiporter
A3857_RS19700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3857_RS19755	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A3857_RS19760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A3857_RS19770	COG0625	glutathione transferase activity
A3857_RS19775	COG1349	DNA-binding transcription factor activity
A3857_RS19785	COG1129	ABC transporter
A3857_RS19790	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS19795	COG1172	Belongs to the binding-protein-dependent transport system permease family
A3857_RS19810	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A3857_RS19815	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS19820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3857_RS19830	COG0765	amino acid transport
A3857_RS19895	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3857_RS19965	COG0393	Putative heavy-metal-binding
A3857_RS20155	COG4974	Belongs to the 'phage' integrase family
A3857_RS20170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A3857_RS20185	COG2358	TRAP transporter, solute receptor (TAXI family
A3857_RS20205	COG0523	cobalamin synthesis protein
A3857_RS20235	COG1192	Involved in chromosome partitioning
A3857_RS20255	COG2801	Transposase and inactivated derivatives
A3857_RS20270	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3857_RS20355	COG3012	SEC-C Motif Domain Protein
A3857_RS20405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3857_RS20435	COG4372	Transposase
A3857_RS20480	COG2161	toxin-antitoxin pair type II binding
A3857_RS20505	COG0640	Transcriptional regulator
A3857_RS20515	COG1192	Involved in chromosome partitioning
A3857_RS20530	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3857_RS20570	COG0659	secondary active sulfate transmembrane transporter activity
A3857_RS20575	COG0589	response to stress
A3857_RS20580	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A3857_RS20590	COG0640	Transcriptional regulator
A3857_RS20595	COG0701	Predicted permease
A3857_RS20610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3857_RS20630	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A3857_RS20830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3857_RS21040	COG0336	Belongs to the RNA methyltransferase TrmD family
A3857_RS21070	COG1192	Involved in chromosome partitioning
A3857_RS21090	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A3857_RS21095	COG1088	dTDP-glucose 4,6-dehydratase activity
A3857_RS21100	COG1091	dTDP-4-dehydrorhamnose reductase activity
A3857_RS21120	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A3857_RS21165	COG1522	sequence-specific DNA binding
A3857_RS21170	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
A3857_RS21175	COG4208	sulfate ABC transporter
A3857_RS21185	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
A3857_RS21190	COG0583	DNA-binding transcription factor activity
A3857_RS21205	COG1959	2 iron, 2 sulfur cluster binding
A3857_RS21215	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A3857_RS21225	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A3857_RS21230	COG4149	molybdate abc transporter
A3857_RS21270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A3857_RS21280	COG5443	negative regulation of bacterial-type flagellum assembly
A3857_RS21290	COG4608	Belongs to the ABC transporter superfamily
A3857_RS21300	COG4948	Mandelate Racemase Muconate Lactonizing
A3857_RS21310	COG3608	succinylglutamate desuccinylase aspartoacylase
A3857_RS21315	COG4948	Mandelate Racemase Muconate Lactonizing
A3857_RS21320	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS21325	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS21340	COG0747	negative chemotaxis
A3857_RS21345	COG1802	Transcriptional regulator
A3857_RS21355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3857_RS21365	COG0659	secondary active sulfate transmembrane transporter activity
A3857_RS21370	COG0589	response to stress
A3857_RS21400	COG2267	carboxylic ester hydrolase activity
A3857_RS21415	COG1280	lysine exporter protein (LysE YggA)
A3857_RS21450	COG1120	ATPase activity
A3857_RS21465	COG4774	siderophore transport
A3857_RS21490	COG2207	Transcriptional regulator
A3857_RS21515	COG4372	Transposase
A3857_RS21565	COG2801	Transposase and inactivated derivatives
A3857_RS21590	COG0356	it plays a direct role in the translocation of protons across the membrane
A3857_RS21630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3857_RS21685	COG0765	amino acid transport
A3857_RS21695	COG1126	abc transporter atp-binding protein
A3857_RS21700	COG0252	asparaginase activity
A3857_RS21705	COG2188	Transcriptional regulator
A3857_RS21710	COG3842	ATPase activity
A3857_RS21715	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS21720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3857_RS21730	COG0395	ABC-type sugar transport system, permease component
A3857_RS21735	COG1175	transmembrane transport
A3857_RS21750	COG1609	Transcriptional regulator
A3857_RS21760	COG2801	Transposase and inactivated derivatives
A3857_RS21785	COG0395	ABC-type sugar transport system, permease component
A3857_RS21790	COG3842	ATPase activity
A3857_RS21795	COG1063	alcohol dehydrogenase
A3857_RS21805	COG0473	3-isopropylmalate dehydrogenase activity
A3857_RS21815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3857_RS21820	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3857_RS21830	COG3180	Ammonia monooxygenase
A3857_RS21840	COG2223	nitrite transmembrane transporter activity
A3857_RS21850	COG1192	Involved in chromosome partitioning
A3857_RS21855	COG1475	DNA binding
A3857_RS21860	COG1414	Transcriptional regulator
A3857_RS21870	COG0114	fumarate hydratase activity
A3857_RS21875	COG0583	DNA-binding transcription factor activity
A3857_RS21885	COG3706	GGDEF domain
A3857_RS21890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3857_RS21895	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A3857_RS21900	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3857_RS21900	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A3857_RS21905	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A3857_RS21905	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A3857_RS21915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3857_RS21920	COG0028	Belongs to the TPP enzyme family
A3857_RS21925	COG2855	membrane
A3857_RS21935	COG5598	trimethylamine methyltransferase
A3857_RS21940	COG4948	Mandelate Racemase Muconate Lactonizing
A3857_RS21945	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS21950	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS21960	COG1012	belongs to the aldehyde dehydrogenase family
A3857_RS21965	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3857_RS21975	COG3448	diguanylate cyclase activity
A3857_RS21975	COG4175	Glycine betaine
A3857_RS21980	COG4176	ABC-type proline glycine betaine transport system permease component
A3857_RS21985	COG2113	Glycine betaine
A3857_RS22015	COG2323	membrane
A3857_RS22060	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3857_RS22065	COG4251	negative regulation of phosphorylation
A3857_RS22070	COG3920	Histidine kinase
A3857_RS22090	COG4638	Rieske (2fe-2S)
A3857_RS22095	COG0583	DNA-binding transcription factor activity
A3857_RS22130	COG1028	Short-chain dehydrogenase reductase Sdr
A3857_RS22150	COG3246	L-lysine catabolic process to acetate
A3857_RS22160	COG0559	Belongs to the binding-protein-dependent transport system permease family
A3857_RS22165	COG4177	L-phenylalanine transmembrane transporter activity
A3857_RS22185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
A3857_RS22210	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3857_RS22245	COG4459	periplasmic nitrate reductase
A3857_RS22255	COG3062	negative regulation of establishment of protein localization
A3857_RS22325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A3857_RS22380	COG2801	Transposase and inactivated derivatives
A3857_RS22395	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3857_RS22440	COG3550	peptidyl-serine autophosphorylation
A3857_RS22445	COG2200	EAL domain
A3857_RS22585	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
A3857_RS22600	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3857_RS22630	COG0438	transferase activity, transferring glycosyl groups
A3857_RS22640	COG0110	maltose O-acetyltransferase activity
A3857_RS22685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3857_RS22690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3857_RS22750	COG1192	Involved in chromosome partitioning
A3857_RS22820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A3857_RS22825	COG0124	histidyl-tRNA synthetase