locus-tag	class	description
B6K69_RS00005	COG3626	phosphonate metabolism
B6K69_RS00010	COG3627	carbon phosphorus lyase activity
B6K69_RS00015	COG4107	phosphonate C-P lyase system protein PhnK
B6K69_RS00025	COG4778	phosphonate C-P lyase system protein PhnL
B6K69_RS00035	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
B6K69_RS00040	COG3454	Phosphonate metabolism
B6K69_RS00050	COG0179	Fumarylacetoacetate (FAA) hydrolase
B6K69_RS00105	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B6K69_RS00110	COG2986	histidine ammonia-lyase
B6K69_RS00160	COG0626	cystathionine gamma-synthase activity
B6K69_RS00165	COG5621	secreted hydrolase
B6K69_RS00170	COG1233	COG1233 Phytoene dehydrogenase and related
B6K69_RS00175	COG0142	geranyltranstransferase activity
B6K69_RS00180	COG0500	methyltransferase
B6K69_RS00185	COG1063	alcohol dehydrogenase
B6K69_RS00190	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B6K69_RS00195	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS00200	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS00235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6K69_RS00245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6K69_RS00265	COG0354	folic acid binding
B6K69_RS00270	COG1132	(ABC) transporter
B6K69_RS00275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B6K69_RS00285	COG0440	acetolactate synthase activity
B6K69_RS00290	COG0028	Belongs to the TPP enzyme family
B6K69_RS00300	COG0625	glutathione transferase activity
B6K69_RS00305	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
B6K69_RS00315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6K69_RS00320	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B6K69_RS00325	COG0704	Plays a role in the regulation of phosphate uptake
B6K69_RS00330	COG0745	RESPONSE REGULATOR receiver
B6K69_RS00355	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6K69_RS00370	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B6K69_RS00380	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6K69_RS00385	COG0546	phosphoglycolate phosphatase activity
B6K69_RS00420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6K69_RS00425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6K69_RS00440	COG0052	Belongs to the universal ribosomal protein uS2 family
B6K69_RS00475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
B6K69_RS00495	COG0713	ATP synthesis coupled electron transport
B6K69_RS00525	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B6K69_RS00535	COG0513	Belongs to the DEAD box helicase family
B6K69_RS00545	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
B6K69_RS00550	COG1914	H( )-stimulated, divalent metal cation uptake system
B6K69_RS00560	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS00565	COG3842	ATPase activity
B6K69_RS00570	COG0800	Aldolase
B6K69_RS00575	COG0129	dihydroxy-acid dehydratase activity
B6K69_RS00590	COG0501	Belongs to the peptidase M48B family
B6K69_RS00605	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6K69_RS00615	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6K69_RS00630	COG0316	Belongs to the HesB IscA family
B6K69_RS00635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
B6K69_RS00645	COG2321	neutral zinc metallopeptidase
B6K69_RS00665	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B6K69_RS00680	COG0559	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS00700	COG0683	leucine binding
B6K69_RS00710	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
B6K69_RS00720	COG1561	YicC-like family, N-terminal region
B6K69_RS00725	COG0194	GDP metabolic process
B6K69_RS00745	COG3962	Belongs to the TPP enzyme family
B6K69_RS00755	COG3718	enzyme involved in inositol metabolism
B6K69_RS00770	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B6K69_RS00775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6K69_RS00780	COG0730	response to heat
B6K69_RS00795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B6K69_RS00800	COG4235	cytochrome complex assembly
B6K69_RS00805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS00815	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS00815	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6K69_RS00835	COG1611	Belongs to the LOG family
B6K69_RS00850	COG5265	(ABC) transporter
B6K69_RS00870	COG1160	GTP binding
B6K69_RS00885	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B6K69_RS00890	COG1862	Preprotein translocase
B6K69_RS00895	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6K69_RS00900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B6K69_RS00905	COG3737	Protein of unknown function (DUF498/DUF598)
B6K69_RS00910	COG0667	Aldo Keto reductase
B6K69_RS00915	COG4133	protoheme IX ABC transporter activity
B6K69_RS00920	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6K69_RS00925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B6K69_RS00935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6K69_RS00970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B6K69_RS00975	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B6K69_RS00990	COG4695	Portal protein
B6K69_RS01075	COG4589	Belongs to the CDS family
B6K69_RS01085	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6K69_RS01090	COG0022	dehydrogenase e1 component
B6K69_RS01090	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6K69_RS01095	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B6K69_RS01105	COG3588	fructose-bisphosphate aldolase
B6K69_RS01130	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B6K69_RS01135	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
B6K69_RS01150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B6K69_RS01170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
B6K69_RS01175	COG0271	Belongs to the BolA IbaG family
B6K69_RS01190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6K69_RS01195	COG0583	DNA-binding transcription factor activity
B6K69_RS01200	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B6K69_RS01225	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
B6K69_RS01250	COG1472	Belongs to the glycosyl hydrolase 3 family
B6K69_RS01255	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B6K69_RS01260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6K69_RS01270	COG0717	Belongs to the dCTP deaminase family
B6K69_RS01290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B6K69_RS01295	COG0416	fatty acid biosynthetic process
B6K69_RS01300	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B6K69_RS01315	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6K69_RS01325	COG0646	methionine synthase
B6K69_RS01325	COG1410	methionine synthase
B6K69_RS01330	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B6K69_RS01340	COG0248	Ppx GppA phosphatase
B6K69_RS01345	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
B6K69_RS01360	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6K69_RS01380	COG0433	COG0433 Predicted ATPase
B6K69_RS01385	COG4536	flavin adenine dinucleotide binding
B6K69_RS01390	COG4974	Belongs to the 'phage' integrase family
B6K69_RS01400	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B6K69_RS01415	COG2081	HI0933 family
B6K69_RS01420	COG1794	racemase activity, acting on amino acids and derivatives
B6K69_RS01425	COG2877	3-deoxy-8-phosphooctulonate synthase activity
B6K69_RS01460	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B6K69_RS01485	COG1177	transmembrane transport
B6K69_RS01500	COG2326	polyphosphate kinase activity
B6K69_RS01510	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B6K69_RS01525	COG0697	spore germination
B6K69_RS01530	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS01530	COG1902	pentaerythritol trinitrate reductase activity
B6K69_RS01535	COG1846	Transcriptional regulator
B6K69_RS01585	COG1129	ABC transporter
B6K69_RS01635	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B6K69_RS01640	COG0776	regulation of translation
B6K69_RS01660	COG0443	Heat shock 70 kDa protein
B6K69_RS01665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B6K69_RS01675	COG2249	NAD(P)H dehydrogenase (quinone) activity
B6K69_RS01695	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
B6K69_RS01715	COG0697	spore germination
B6K69_RS01725	COG0359	binds to the 23S rRNA
B6K69_RS01730	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B6K69_RS01735	COG0360	Binds together with S18 to 16S ribosomal RNA
B6K69_RS01740	COG2353	YceI-like domain
B6K69_RS01755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B6K69_RS01765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B6K69_RS01770	COG1957	nucleoside hydrolase
B6K69_RS01775	COG1840	ABC-type Fe3 transport system, periplasmic component
B6K69_RS01780	COG3956	TIGRFAM MazG family protein
B6K69_RS01785	COG1473	amidohydrolase
B6K69_RS01795	COG0010	Belongs to the arginase family
B6K69_RS01805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B6K69_RS01810	COG2890	protein-(glutamine-N5) methyltransferase activity
B6K69_RS01820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6K69_RS01825	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
B6K69_RS01830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6K69_RS01835	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
B6K69_RS01845	COG0795	lipopolysaccharide-transporting ATPase activity
B6K69_RS01850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6K69_RS01860	COG3577	Aspartyl protease
B6K69_RS01865	COG2095	MarC family integral membrane protein
B6K69_RS01870	COG0488	(ABC) transporter
B6K69_RS01875	COG0105	UTP biosynthetic process
B6K69_RS01900	COG1959	2 iron, 2 sulfur cluster binding
B6K69_RS01905	COG0058	SHG alpha-glucan phosphorylase activity
B6K69_RS01910	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B6K69_RS01915	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B6K69_RS01920	COG0297	glycogen (starch) synthase activity
B6K69_RS01930	COG0033	Phosphoglucomutase
B6K69_RS01935	COG5598	trimethylamine methyltransferase
B6K69_RS01940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B6K69_RS01945	COG1597	lipid kinase activity
B6K69_RS02000	COG2771	luxR family
B6K69_RS02020	COG2313	pseudouridylate synthase activity
B6K69_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS02040	COG4166	transmembrane transport
B6K69_RS02065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B6K69_RS02070	COG2814	Major facilitator Superfamily
B6K69_RS02075	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B6K69_RS02100	COG2084	Dehydrogenase
B6K69_RS02110	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B6K69_RS02115	COG1923	regulation of RNA biosynthetic process
B6K69_RS02120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6K69_RS02125	COG0569	domain protein
B6K69_RS02130	COG2204	response regulator
B6K69_RS02140	COG2204	response regulator
B6K69_RS02145	COG3852	Histidine kinase
B6K69_RS02150	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B6K69_RS02155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B6K69_RS02155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B6K69_RS02165	COG1546	Belongs to the CinA family
B6K69_RS02175	COG2867	negative regulation of translational initiation
B6K69_RS02180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
B6K69_RS02185	COG2010	Cytochrome c
B6K69_RS02245	COG0577	efflux transmembrane transporter activity
B6K69_RS02245	COG1136	(ABC) transporter
B6K69_RS02250	COG0577	efflux transmembrane transporter activity
B6K69_RS02250	COG1136	(ABC) transporter
B6K69_RS02260	COG3239	Fatty acid desaturase
B6K69_RS02265	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B6K69_RS02285	COG0148	phosphopyruvate hydratase activity
B6K69_RS02300	COG2962	Rard protein
B6K69_RS02305	COG2354	Protein conserved in bacteria
B6K69_RS02325	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B6K69_RS02335	COG0583	DNA-binding transcription factor activity
B6K69_RS02355	COG0121	glutamine amidotransferase
B6K69_RS02365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6K69_RS02370	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B6K69_RS02385	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B6K69_RS02385	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6K69_RS02405	COG3842	ATPase activity
B6K69_RS02410	COG0366	Alpha amylase catalytic
B6K69_RS02415	COG0395	ABC-type sugar transport system, permease component
B6K69_RS02420	COG1175	transmembrane transport
B6K69_RS02425	COG1653	transport
B6K69_RS02430	COG1609	Transcriptional regulator
B6K69_RS02435	COG2723	6-phospho-beta-galactosidase activity
B6K69_RS02440	COG0837	glucose binding
B6K69_RS02455	COG2814	Major facilitator Superfamily
B6K69_RS02465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6K69_RS02470	COG0215	cysteine-tRNA ligase activity
B6K69_RS02485	COG0076	glutamate decarboxylase activity
B6K69_RS02500	COG0488	(ABC) transporter
B6K69_RS02525	COG0251	oxidation-reduction process
B6K69_RS02540	COG0166	Belongs to the GPI family
B6K69_RS02550	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B6K69_RS02570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6K69_RS02585	COG0719	Fe-S assembly protein
B6K69_RS02590	COG0396	ATPase activity
B6K69_RS02600	COG0719	Fe-S assembly protein
B6K69_RS02615	COG2945	thiolester hydrolase activity
B6K69_RS02630	COG0538	isocitrate dehydrogenase activity
B6K69_RS02655	COG1217	gtp-binding protein TYPA
B6K69_RS02675	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B6K69_RS02685	COG0477	Major facilitator Superfamily
B6K69_RS02690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B6K69_RS02700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B6K69_RS02705	COG2833	Protein of unknown function (DUF455)
B6K69_RS02710	COG0739	heme binding
B6K69_RS02725	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
B6K69_RS02730	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
B6K69_RS02735	COG0860	N-Acetylmuramoyl-L-alanine amidase
B6K69_RS02740	COG0436	Aminotransferase
B6K69_RS02750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B6K69_RS02760	COG0156	8-amino-7-oxononanoate synthase activity
B6K69_RS02795	COG1741	Belongs to the pirin family
B6K69_RS02800	COG0024	Methionine aminopeptidase
B6K69_RS02805	COG1840	ABC-type Fe3 transport system, periplasmic component
B6K69_RS02815	COG3842	ATPase activity
B6K69_RS02820	COG0483	inositol monophosphate 1-phosphatase activity
B6K69_RS02825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6K69_RS02840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
B6K69_RS02845	COG4942	peptidase
B6K69_RS02850	COG1253	flavin adenine dinucleotide binding
B6K69_RS02860	COG0805	protein transport
B6K69_RS02870	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B6K69_RS02885	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
B6K69_RS02910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B6K69_RS02920	COG1177	transmembrane transport
B6K69_RS02930	COG3842	ATPase activity
B6K69_RS02945	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
B6K69_RS02965	COG3483	tryptophan 2,3-dioxygenase activity
B6K69_RS02970	COG1376	ErfK ybiS ycfS ynhG family protein
B6K69_RS02980	COG3759	membrane
B6K69_RS02985	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
B6K69_RS03000	COG3932	Exopolysaccharide synthesis, ExoD
B6K69_RS03010	COG1024	Enoyl-CoA hydratase
B6K69_RS03015	COG3088	subunit of a heme lyase
B6K69_RS03020	COG1138	Cytochrome C-type biogenesis protein
B6K69_RS03025	COG1509	lysine 2,3-aminomutase activity
B6K69_RS03030	COG5425	PFAM Usg family protein
B6K69_RS03035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6K69_RS03055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6K69_RS03070	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B6K69_RS03075	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B6K69_RS03080	COG0745	RESPONSE REGULATOR receiver
B6K69_RS03090	COG0482	sulfurtransferase activity
B6K69_RS03095	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6K69_RS03100	COG3494	Protein of unknown function (DUF1009)
B6K69_RS03105	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
B6K69_RS03120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6K69_RS03125	COG0750	zinc metalloprotease
B6K69_RS03130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B6K69_RS03140	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B6K69_RS03145	COG0233	cytoplasmic translational termination
B6K69_RS03170	COG0601	transmembrane transport
B6K69_RS03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS03185	COG1522	sequence-specific DNA binding
B6K69_RS03195	COG0741	lytic transglycosylase activity
B6K69_RS03200	COG0629	single-stranded DNA binding
B6K69_RS03210	COG2151	metal-sulfur cluster biosynthetic enzyme
B6K69_RS03225	COG0316	Belongs to the HesB IscA family
B6K69_RS03230	COG0149	triose-phosphate isomerase activity
B6K69_RS03240	COG2124	cytochrome p450
B6K69_RS03245	COG1522	sequence-specific DNA binding
B6K69_RS03250	COG1648	precorrin-2 dehydrogenase activity
B6K69_RS03250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6K69_RS03260	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B6K69_RS03265	COG0175	sulfate reduction
B6K69_RS03285	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B6K69_RS03295	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B6K69_RS03320	COG1960	acyl-CoA dehydrogenase activity
B6K69_RS03335	COG0418	dihydroorotase activity
B6K69_RS03345	COG0305	Participates in initiation and elongation during chromosome replication
B6K69_RS03360	COG1127	ABC transporter
B6K69_RS03370	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B6K69_RS03390	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B6K69_RS03405	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B6K69_RS03410	COG1562	ergosterol biosynthetic process
B6K69_RS03415	COG1233	COG1233 Phytoene dehydrogenase and related
B6K69_RS03425	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B6K69_RS03430	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
B6K69_RS03440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
B6K69_RS03445	COG0644	oxidoreductase
B6K69_RS03450	COG2211	Major facilitator Superfamily
B6K69_RS03455	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
B6K69_RS03460	COG1719	4-vinyl reductase, 4VR
B6K69_RS03465	COG1032	radical SAM domain protein
B6K69_RS03485	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS03490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS03495	COG1429	ligase activity, forming nitrogen-metal bonds
B6K69_RS03500	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
B6K69_RS03535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B6K69_RS03545	COG0156	8-amino-7-oxononanoate synthase activity
B6K69_RS03560	COG0437	4 iron, 4 sulfur cluster binding
B6K69_RS03565	COG0243	molybdopterin cofactor binding
B6K69_RS03570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B6K69_RS03580	COG0028	Belongs to the TPP enzyme family
B6K69_RS03585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6K69_RS03590	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B6K69_RS03595	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6K69_RS03605	COG2204	response regulator
B6K69_RS03615	COG0835	chemotaxis
B6K69_RS03620	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B6K69_RS03635	COG2201	protein-glutamate methylesterase activity
B6K69_RS03645	COG1959	2 iron, 2 sulfur cluster binding
B6K69_RS03655	COG0583	DNA-binding transcription factor activity
B6K69_RS03660	COG4149	molybdate abc transporter
B6K69_RS03665	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B6K69_RS03680	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
B6K69_RS03695	COG2205	protein histidine kinase activity
B6K69_RS03710	COG0745	RESPONSE REGULATOR receiver
B6K69_RS03740	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS03745	COG4372	Transposase
B6K69_RS03790	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B6K69_RS03795	COG0134	indole-3-glycerol-phosphate synthase activity
B6K69_RS03810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B6K69_RS03815	COG0658	competence protein
B6K69_RS03815	COG2333	competence protein COMEC
B6K69_RS03820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B6K69_RS03825	COG0372	Belongs to the citrate synthase family
B6K69_RS03845	COG1733	regulation of RNA biosynthetic process
B6K69_RS03850	COG5507	3-demethylubiquinone-9 3-methyltransferase
B6K69_RS03865	COG0525	valine-tRNA ligase activity
B6K69_RS03880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B6K69_RS03890	COG0308	aminopeptidase N
B6K69_RS03895	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B6K69_RS03900	COG2124	cytochrome p450
B6K69_RS03910	COG0785	Cytochrome C biogenesis protein
B6K69_RS03920	COG1530	ribonuclease E activity
B6K69_RS03925	COG2204	response regulator
B6K69_RS03935	COG0047	phosphoribosylformylglycinamidine synthase activity
B6K69_RS03940	COG0277	FAD linked oxidase domain protein
B6K69_RS03955	COG0497	DNA recombination
B6K69_RS03960	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6K69_RS03975	COG0849	cell division
B6K69_RS03980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B6K69_RS03985	COG1181	Belongs to the D-alanine--D-alanine ligase family
B6K69_RS03990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B6K69_RS04020	COG0039	L-malate dehydrogenase activity
B6K69_RS04035	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
B6K69_RS04040	COG0352	thiamine-phosphate diphosphorylase activity
B6K69_RS04045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B6K69_RS04045	COG1796	DNA polymerase
B6K69_RS04055	COG4221	oxidoreductase activity
B6K69_RS04080	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
B6K69_RS04100	COG3750	Belongs to the UPF0335 family
B6K69_RS04150	COG0745	RESPONSE REGULATOR receiver
B6K69_RS04170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6K69_RS04175	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6K69_RS04180	COG1116	anion transmembrane transporter activity
B6K69_RS04185	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B6K69_RS04195	COG1309	transcriptional regulator
B6K69_RS04205	COG4702	Belongs to the UPF0303 family
B6K69_RS04210	COG1309	transcriptional regulator
B6K69_RS04230	COG0493	'glutamate synthase
B6K69_RS04235	COG0511	ligase activity, forming carbon-carbon bonds
B6K69_RS04240	COG0439	Biotin carboxylase
B6K69_RS04245	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
B6K69_RS04265	COG0251	oxidation-reduction process
B6K69_RS04285	COG4134	Bacterial extracellular solute-binding protein
B6K69_RS04290	COG4135	transport system, permease component
B6K69_RS04295	COG4136	ATPase activity
B6K69_RS04405	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B6K69_RS04405	COG1648	precorrin-2 dehydrogenase activity
B6K69_RS04410	COG2875	Belongs to the precorrin methyltransferase family
B6K69_RS04425	COG2099	Precorrin-6x reductase
B6K69_RS04465	COG1492	cobalamin metabolic process
B6K69_RS04470	COG0778	Nitroreductase
B6K69_RS04485	COG1473	amidohydrolase
B6K69_RS04495	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B6K69_RS04500	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS04505	COG4608	Belongs to the ABC transporter superfamily
B6K69_RS04515	COG0601	transmembrane transport
B6K69_RS04520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS04535	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B6K69_RS04575	COG0798	PFAM Bile acid sodium symporter
B6K69_RS04585	COG3386	PFAM SMP-30 Gluconolaconase
B6K69_RS04590	COG0800	Aldolase
B6K69_RS04595	COG3734	2-keto-3-deoxy-galactonokinase
B6K69_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS04605	COG1414	Transcriptional regulator
B6K69_RS04610	COG3721	Heme iron utilization protein
B6K69_RS04620	COG2943	transferase activity, transferring hexosyl groups
B6K69_RS04625	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
B6K69_RS04640	COG1396	sequence-specific DNA binding
B6K69_RS04645	COG0156	8-amino-7-oxononanoate synthase activity
B6K69_RS04650	COG1063	alcohol dehydrogenase
B6K69_RS04670	COG1278	Cold shock
B6K69_RS04675	COG0259	pyridoxamine-phosphate oxidase activity
B6K69_RS04680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6K69_RS04690	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
B6K69_RS04695	COG0436	Aminotransferase
B6K69_RS04705	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6K69_RS04715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6K69_RS04730	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B6K69_RS04730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B6K69_RS04745	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
B6K69_RS04745	COG1618	nucleotide phosphatase activity, acting on free nucleotides
B6K69_RS04765	COG0747	negative chemotaxis
B6K69_RS04770	COG0601	transmembrane transport
B6K69_RS04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS04780	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS04785	COG4608	Belongs to the ABC transporter superfamily
B6K69_RS04800	COG0826	peptidase U32
B6K69_RS04890	COG0375	protein maturation
B6K69_RS04935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6K69_RS04955	COG0006	proline dipeptidase activity
B6K69_RS04960	COG2166	iron-sulfur cluster assembly
B6K69_RS04970	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
B6K69_RS04975	COG1902	pentaerythritol trinitrate reductase activity
B6K69_RS04985	COG2832	Protein of unknown function (DUF454)
B6K69_RS04990	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B6K69_RS04995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B6K69_RS05070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6K69_RS05085	COG0583	DNA-binding transcription factor activity
B6K69_RS05110	COG1793	dna ligase
B6K69_RS05120	COG0456	acetyltransferase
B6K69_RS05140	COG1183	phosphatidylcholine synthase activity
B6K69_RS05145	COG0688	phosphatidylethanolamine metabolic process
B6K69_RS05160	COG0564	pseudouridine synthase activity
B6K69_RS05175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B6K69_RS05180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6K69_RS05205	COG3842	ATPase activity
B6K69_RS05215	COG1177	transmembrane transport
B6K69_RS05225	COG0154	amidase activity
B6K69_RS05240	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS05250	COG1519	Transferase
B6K69_RS05275	COG2089	acid synthase
B6K69_RS05285	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6K69_RS05290	COG0386	Belongs to the glutathione peroxidase family
B6K69_RS05305	COG1846	Transcriptional regulator
B6K69_RS05310	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
B6K69_RS05315	COG1396	sequence-specific DNA binding
B6K69_RS05330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B6K69_RS05355	COG0612	Peptidase, M16
B6K69_RS05365	COG3346	SURF1 family
B6K69_RS05375	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
B6K69_RS05395	COG0312	modulator of DNA gyrase
B6K69_RS05440	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
B6K69_RS05445	COG0384	phenazine biosynthesis protein PhzF
B6K69_RS05465	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6K69_RS05475	COG4215	(ABC) transporter
B6K69_RS05480	COG4160	amino acid transport
B6K69_RS05485	COG0174	glutamine synthetase
B6K69_RS05490	COG0519	Catalyzes the synthesis of GMP from XMP
B6K69_RS05495	COG0174	glutamine synthetase
B6K69_RS05500	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS05505	COG0358	DNA primase activity
B6K69_RS05510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B6K69_RS05515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6K69_RS05515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6K69_RS05525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6K69_RS05530	COG4770	biotin carboxylase activity
B6K69_RS05555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B6K69_RS05570	COG1396	sequence-specific DNA binding
B6K69_RS05570	COG3800	Transcriptional regulator
B6K69_RS05580	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
B6K69_RS05590	COG1309	transcriptional regulator
B6K69_RS05605	COG4175	Glycine betaine
B6K69_RS05610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B6K69_RS05610	COG1754	DNA topoisomerase type I activity
B6K69_RS05615	COG0758	DNA mediated transformation
B6K69_RS05620	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B6K69_RS05630	COG1122	ATPase activity
B6K69_RS05640	COG1268	BioY protein
B6K69_RS05660	COG0583	DNA-binding transcription factor activity
B6K69_RS05665	COG0488	(ABC) transporter
B6K69_RS05675	COG0483	inositol monophosphate 1-phosphatase activity
B6K69_RS05685	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B6K69_RS05685	COG0506	proline dehydrogenase activity
B6K69_RS05685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
B6K69_RS05690	COG1522	sequence-specific DNA binding
B6K69_RS05695	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6K69_RS05700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6K69_RS05715	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B6K69_RS05725	COG0741	lytic transglycosylase activity
B6K69_RS05745	COG4964	Belongs to the GSP D family
B6K69_RS05800	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B6K69_RS05805	COG2239	Acts as a magnesium transporter
B6K69_RS05810	COG0402	S-adenosylhomocysteine deaminase activity
B6K69_RS05840	COG0483	inositol monophosphate 1-phosphatase activity
B6K69_RS05855	COG0583	DNA-binding transcription factor activity
B6K69_RS05865	COG0670	Belongs to the BI1 family
B6K69_RS05885	COG3023	N-Acetylmuramoyl-L-alanine amidase
B6K69_RS05895	COG0154	amidase activity
B6K69_RS05915	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B6K69_RS05920	COG0590	tRNA wobble adenosine to inosine editing
B6K69_RS05925	COG1187	pseudouridine synthase activity
B6K69_RS05935	COG3853	Toxic anion resistance protein (TelA)
B6K69_RS05970	COG0481	GTPase activity
B6K69_RS05980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B6K69_RS06000	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B6K69_RS06005	COG0488	(ABC) transporter
B6K69_RS06010	COG1703	isobutyryl-CoA mutase activity
B6K69_RS06030	COG0815	Transfers the fatty acyl group on membrane lipoproteins
B6K69_RS06035	COG1253	flavin adenine dinucleotide binding
B6K69_RS06040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B6K69_RS06045	COG1643	Atp-dependent helicase
B6K69_RS06050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6K69_RS06080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B6K69_RS06095	COG1335	isochorismatase
B6K69_RS06100	COG2223	nitrite transmembrane transporter activity
B6K69_RS06110	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6K69_RS06115	COG1702	phosphate starvation-inducible protein PhoH
B6K69_RS06125	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B6K69_RS06135	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B6K69_RS06165	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
B6K69_RS06175	COG3604	Transcriptional regulator
B6K69_RS06180	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B6K69_RS06185	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
B6K69_RS06190	COG0644	oxidoreductase
B6K69_RS06195	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B6K69_RS06200	COG2086	electron transfer activity
B6K69_RS06260	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS06265	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
B6K69_RS06285	COG3781	membrane
B6K69_RS06310	COG1872	DUF167
B6K69_RS06370	COG0509	glycine decarboxylation via glycine cleavage system
B6K69_RS06375	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6K69_RS06395	COG1234	tRNA 3'-trailer cleavage
B6K69_RS06400	COG0655	NAD(P)H dehydrogenase (quinone) activity
B6K69_RS06410	COG1283	sodium-dependent phosphate transmembrane transporter activity
B6K69_RS06430	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B6K69_RS06450	COG1183	phosphatidylcholine synthase activity
B6K69_RS06460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6K69_RS06475	COG0583	DNA-binding transcription factor activity
B6K69_RS06485	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B6K69_RS06520	COG0133	tryptophan synthase activity
B6K69_RS06530	COG0778	Nitroreductase
B6K69_RS06535	COG0539	negative regulation of cytoplasmic translation
B6K69_RS06540	COG0776	regulation of translation
B6K69_RS06555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B6K69_RS06560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B6K69_RS06595	COG1960	acyl-CoA dehydrogenase activity
B6K69_RS06600	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6K69_RS06600	COG0824	Thioesterase
B6K69_RS06610	COG3246	L-lysine catabolic process to acetate
B6K69_RS06625	COG0765	amino acid transport
B6K69_RS06630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6K69_RS06635	COG3384	dioxygenase
B6K69_RS06640	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B6K69_RS06650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B6K69_RS06680	COG0606	chelatase, subunit chli
B6K69_RS06695	COG0792	nuclease activity
B6K69_RS06700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B6K69_RS06710	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
B6K69_RS06725	COG0180	Tryptophanyl-tRNA synthetase
B6K69_RS06740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6K69_RS06785	COG2390	Transcriptional regulator
B6K69_RS06790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6K69_RS06795	COG1024	Enoyl-CoA hydratase
B6K69_RS06795	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6K69_RS06810	COG0183	Belongs to the thiolase family
B6K69_RS06825	COG1960	acyl-CoA dehydrogenase activity
B6K69_RS06860	COG4214	carbohydrate transport
B6K69_RS06875	COG0129	dihydroxy-acid dehydratase activity
B6K69_RS06890	COG1879	ABC-type sugar transport system periplasmic component
B6K69_RS06895	COG1129	ABC transporter
B6K69_RS06900	COG1172	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS06915	COG0534	Mate efflux family protein
B6K69_RS06925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6K69_RS06940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B6K69_RS06955	COG1744	ABC transporter substrate-binding protein PnrA-like
B6K69_RS06960	COG3845	ABC transporter
B6K69_RS06965	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS06970	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS06980	COG0730	response to heat
B6K69_RS06990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6K69_RS06995	COG1737	Transcriptional regulator
B6K69_RS07015	COG0174	glutamine synthetase
B6K69_RS07035	COG0861	Integral membrane protein TerC family
B6K69_RS07040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B6K69_RS07065	COG1309	transcriptional regulator
B6K69_RS07085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B6K69_RS07100	COG3768	UPF0283 membrane protein
B6K69_RS07105	COG3106	COG3106 Predicted ATPase
B6K69_RS07110	COG0101	tRNA pseudouridine synthase activity
B6K69_RS07120	COG0745	RESPONSE REGULATOR receiver
B6K69_RS07135	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B6K69_RS07140	COG0659	secondary active sulfate transmembrane transporter activity
B6K69_RS07155	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
B6K69_RS07165	COG2027	D-alanyl-D-alanine carboxypeptidase
B6K69_RS07175	COG0488	(ABC) transporter
B6K69_RS07185	COG1278	Cold shock
B6K69_RS07195	COG0235	Class ii aldolase
B6K69_RS07210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS07230	COG3119	arylsulfatase activity
B6K69_RS07235	COG0490	domain, Protein
B6K69_RS07235	COG0471	metal ion transport
B6K69_RS07255	COG0747	negative chemotaxis
B6K69_RS07260	COG0601	transmembrane transport
B6K69_RS07265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS07295	COG0698	ribose 5-phosphate isomerase
B6K69_RS07305	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B6K69_RS07310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B6K69_RS07325	COG3180	Ammonia monooxygenase
B6K69_RS07340	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B6K69_RS07350	COG3845	ABC transporter
B6K69_RS07355	COG4603	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS07360	COG1079	Belongs to the binding-protein-dependent transport system permease family
B6K69_RS07370	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS07375	COG0583	DNA-binding transcription factor activity
B6K69_RS07380	COG1850	ribulose-bisphosphate carboxylase activity
B6K69_RS07405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6K69_RS07425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6K69_RS07445	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B6K69_RS07450	COG1121	(ABC) transporter
B6K69_RS07455	COG0735	belongs to the Fur family
B6K69_RS07465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B6K69_RS07470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B6K69_RS07475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B6K69_RS07485	COG2226	methyltransferase
B6K69_RS07495	COG0737	Belongs to the 5'-nucleotidase family
B6K69_RS07505	COG0167	dihydroorotate dehydrogenase activity
B6K69_RS07525	COG0604	alcohol dehydrogenase
B6K69_RS07530	COG2937	Belongs to the GPAT DAPAT family
B6K69_RS07535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6K69_RS07535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
B6K69_RS07555	COG0813	purine-nucleoside phosphorylase activity
B6K69_RS07560	COG0583	DNA-binding transcription factor activity
B6K69_RS07565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6K69_RS07620	COG2030	dehydratase
B6K69_RS07640	COG3237	CsbD-like
B6K69_RS07650	COG0039	L-malate dehydrogenase activity
B6K69_RS07655	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B6K69_RS07660	COG2195	Cleaves the N-terminal amino acid of tripeptides
B6K69_RS07675	COG0045	succinate-CoA ligase (ADP-forming) activity
B6K69_RS07680	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B6K69_RS07720	COG1741	Belongs to the pirin family
B6K69_RS07725	COG1802	Transcriptional regulator
B6K69_RS07745	COG0583	DNA-binding transcription factor activity
B6K69_RS07830	COG0776	regulation of translation
B6K69_RS08040	COG5000	phosphorelay sensor kinase activity
B6K69_RS08060	COG0594	ribonuclease P activity
B6K69_RS08065	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B6K69_RS08085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6K69_RS08090	COG4597	amino acid ABC transporter
B6K69_RS08100	COG1126	abc transporter atp-binding protein
B6K69_RS08120	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
B6K69_RS08125	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS08135	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B6K69_RS08150	COG2202	Pas domain
B6K69_RS08150	COG2199	diguanylate cyclase activity
B6K69_RS08150	COG2200	EAL domain
B6K69_RS08155	COG0037	tRNA processing
B6K69_RS08160	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B6K69_RS08165	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B6K69_RS08180	COG0203	ribosomal protein L17
B6K69_RS08185	COG0202	RNA polymerase activity
B6K69_RS08190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B6K69_RS08195	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B6K69_RS08200	COG0563	adenylate kinase activity
B6K69_RS08205	COG0201	protein transport
B6K69_RS08210	COG0200	Binds to the 23S rRNA
B6K69_RS08215	COG1686	Belongs to the peptidase S11 family
B6K69_RS08240	COG0348	domain, Protein
B6K69_RS08245	COG2010	Cytochrome c
B6K69_RS08275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6K69_RS08280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6K69_RS08285	COG0438	transferase activity, transferring glycosyl groups
B6K69_RS08290	COG4172	Belongs to the ABC transporter superfamily
B6K69_RS08295	COG4239	(ABC) transporter, permease
B6K69_RS08300	COG4174	ABC transporter (Permease)
B6K69_RS08305	COG4166	transmembrane transport
B6K69_RS08325	COG2816	NAD+ diphosphatase activity
B6K69_RS08330	COG0737	Belongs to the 5'-nucleotidase family
B6K69_RS08335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6K69_RS08340	COG0741	lytic transglycosylase activity
B6K69_RS08345	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6K69_RS08370	COG2897	thiosulfate sulfurtransferase activity
B6K69_RS08380	COG0004	ammonium transporteR
B6K69_RS08385	COG0347	Belongs to the P(II) protein family
B6K69_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS08420	COG0768	penicillin binding
B6K69_RS08425	COG0772	Belongs to the SEDS family
B6K69_RS08435	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B6K69_RS08445	COG1496	oxidoreductase activity
B6K69_RS08450	COG1522	sequence-specific DNA binding
B6K69_RS08455	COG0492	ferredoxin-NADP+ reductase activity
B6K69_RS08465	COG0529	Catalyzes the synthesis of activated sulfate
B6K69_RS08465	COG2046	Belongs to the sulfate adenylyltransferase family
B6K69_RS08470	COG3038	cytochrome b561
B6K69_RS08480	COG0071	Belongs to the small heat shock protein (HSP20) family
B6K69_RS08490	COG3047	cAMP biosynthetic process
B6K69_RS08505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B6K69_RS08520	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6K69_RS08530	COG0459	protein refolding
B6K69_RS08555	COG2853	Lipoprotein
B6K69_RS08560	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
B6K69_RS08565	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6K69_RS08590	COG2154	pterin-4-alpha-carbinolamine dehydratase
B6K69_RS08595	COG0678	peroxiredoxin activity
B6K69_RS08605	COG0742	ribosomal rna small subunit methyltransferase
B6K69_RS08610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B6K69_RS08615	COG1902	pentaerythritol trinitrate reductase activity
B6K69_RS08615	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS08620	COG0583	DNA-binding transcription factor activity
B6K69_RS08635	COG1546	Belongs to the CinA family
B6K69_RS08635	COG1058	Belongs to the CinA family
B6K69_RS08640	COG0024	Methionine aminopeptidase
B6K69_RS08645	COG0427	acetyl-CoA hydrolase
B6K69_RS08675	COG0129	dihydroxy-acid dehydratase activity
B6K69_RS08680	COG0072	phenylalanine-tRNA ligase activity
B6K69_RS08680	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6K69_RS08765	COG3191	aminopeptidase activity
B6K69_RS08770	COG0314	molybdopterin synthase activity
B6K69_RS08780	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B6K69_RS08790	COG0322	excinuclease ABC activity
B6K69_RS08835	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B6K69_RS08845	COG0612	Peptidase, M16
B6K69_RS08850	COG0612	Peptidase, M16
B6K69_RS08890	COG3806	Anti-sigma factor
B6K69_RS08895	COG1595	DNA-templated transcription, initiation
B6K69_RS08900	COG0730	response to heat
B6K69_RS08905	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
B6K69_RS08925	COG0300	oxidoreductase activity
B6K69_RS08950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B6K69_RS08955	COG3698	Phosphodiester glycosidase
B6K69_RS08960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B6K69_RS08985	COG1185	polyribonucleotide nucleotidyltransferase activity
B6K69_RS08995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS09000	COG0523	cobalamin synthesis protein
B6K69_RS09015	COG0450	alkyl hydroperoxide reductase
B6K69_RS09025	COG1902	pentaerythritol trinitrate reductase activity
B6K69_RS09025	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS09035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS09035	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
B6K69_RS09045	COG0656	L-ascorbic acid biosynthetic process
B6K69_RS09065	COG2271	Major facilitator Superfamily
B6K69_RS09070	COG0366	Alpha amylase catalytic
B6K69_RS09080	COG0793	Belongs to the peptidase S41A family
B6K69_RS09090	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B6K69_RS09095	COG0697	spore germination
B6K69_RS09100	COG0697	spore germination
B6K69_RS09145	COG3842	ATPase activity
B6K69_RS09150	COG3842	ATPase activity
B6K69_RS09160	COG0395	ABC-type sugar transport system, permease component
B6K69_RS09180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B6K69_RS09185	COG1454	alcohol dehydrogenase
B6K69_RS09200	COG1609	Transcriptional regulator
B6K69_RS09210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B6K69_RS09215	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B6K69_RS09245	COG4650	regulator
B6K69_RS09255	COG0583	DNA-binding transcription factor activity
B6K69_RS09265	COG0747	negative chemotaxis
B6K69_RS09270	COG0601	transmembrane transport
B6K69_RS09275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS09280	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS09285	COG4608	Belongs to the ABC transporter superfamily
B6K69_RS09295	COG0765	amino acid transport
B6K69_RS09305	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B6K69_RS09325	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6K69_RS09325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6K69_RS09335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B6K69_RS09335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
B6K69_RS09340	COG1477	protein flavinylation
B6K69_RS09370	COG0642	Histidine kinase
B6K69_RS09395	COG0019	diaminopimelate decarboxylase activity
B6K69_RS09420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6K69_RS09430	COG3474	cytochrome
B6K69_RS09510	COG1850	ribulose-bisphosphate carboxylase activity
B6K69_RS09575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
B6K69_RS09595	COG0667	Aldo Keto reductase
B6K69_RS09600	COG1295	ribonuclease BN
B6K69_RS09605	COG2115	Belongs to the xylose isomerase family
B6K69_RS09610	COG1070	Carbohydrate kinase
B6K69_RS09620	COG4214	carbohydrate transport
B6K69_RS09625	COG1879	ABC-type sugar transport system periplasmic component
B6K69_RS09630	COG1940	carbohydrate kinase activity
B6K69_RS09640	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B6K69_RS09665	COG2985	domain, Protein
B6K69_RS09665	COG0569	domain protein
B6K69_RS09685	COG2884	Cell division ATP-binding protein ftsE
B6K69_RS09700	COG0019	diaminopimelate decarboxylase activity
B6K69_RS09720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B6K69_RS09735	COG0745	RESPONSE REGULATOR receiver
B6K69_RS09755	COG0825	malonyl-CoA metabolic process
B6K69_RS09760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B6K69_RS09760	COG0617	tRNA 3'-terminal CCA addition
B6K69_RS09760	COG0517	IMP dehydrogenase activity
B6K69_RS09765	COG2301	Belongs to the HpcH HpaI aldolase family
B6K69_RS09775	COG4948	Mandelate Racemase Muconate Lactonizing
B6K69_RS09805	COG0469	pyruvate kinase activity
B6K69_RS09820	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B6K69_RS09825	COG1115	amino acid carrier protein
B6K69_RS09835	COG2081	HI0933 family
B6K69_RS09855	COG0312	modulator of DNA gyrase
B6K69_RS09860	COG1218	3'(2'),5'-bisphosphate nucleotidase
B6K69_RS09875	COG0861	Integral membrane protein TerC family
B6K69_RS09880	COG4143	(ABC) transporter
B6K69_RS09890	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
B6K69_RS09910	COG0625	glutathione transferase activity
B6K69_RS09930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B6K69_RS09945	COG1566	PFAM secretion protein HlyD family protein
B6K69_RS09950	COG2814	Major facilitator Superfamily
B6K69_RS09970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B6K69_RS09995	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B6K69_RS10010	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B6K69_RS10030	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B6K69_RS10040	COG5443	negative regulation of bacterial-type flagellum assembly
B6K69_RS10060	COG1558	bacterial-type flagellum-dependent cell motility
B6K69_RS10065	COG1677	Flagellar hook-basal body complex protein FliE
B6K69_RS10070	COG1987	bacterial-type flagellum assembly
B6K69_RS10075	COG4786	Flagellar basal body rod
B6K69_RS10080	COG4786	Flagellar basal body rod
B6K69_RS10090	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
B6K69_RS10110	COG1684	flagellar biosynthetic protein fliR
B6K69_RS10115	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B6K69_RS10130	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B6K69_RS10150	COG1766	The M ring may be actively involved in energy transduction
B6K69_RS10160	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B6K69_RS10165	COG1338	Plays a role in the flagellum-specific transport system
B6K69_RS10180	COG0673	inositol 2-dehydrogenase activity
B6K69_RS10185	COG0395	ABC-type sugar transport system, permease component
B6K69_RS10190	COG1175	transmembrane transport
B6K69_RS10200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B6K69_RS10205	COG2971	BadF BadG BcrA BcrD
B6K69_RS10210	COG2188	Transcriptional regulator
B6K69_RS10215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B6K69_RS10220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B6K69_RS10240	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
B6K69_RS10260	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS10285	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B6K69_RS10295	COG1074	ATP-dependent DNA helicase activity
B6K69_RS10310	COG3178	'Phosphotransferase
B6K69_RS10330	COG1999	signal sequence binding
B6K69_RS10335	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
B6K69_RS10345	COG0583	DNA-binding transcription factor activity
B6K69_RS10350	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
B6K69_RS10360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
B6K69_RS10375	COG2223	nitrite transmembrane transporter activity
B6K69_RS10390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B6K69_RS10395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B6K69_RS10435	COG2818	Glycosylase
B6K69_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS10480	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B6K69_RS10490	COG2308	Evidence 4 Homologs of previously reported genes of
B6K69_RS10500	COG1305	Transglutaminase-like
B6K69_RS10510	COG0829	nickel cation binding
B6K69_RS10515	COG0831	urea catabolic process
B6K69_RS10520	COG0832	Belongs to the urease beta subunit family
B6K69_RS10525	COG0804	urea catabolic process
B6K69_RS10530	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
B6K69_RS10535	COG0830	nickel cation binding
B6K69_RS10555	COG0022	dehydrogenase e1 component
B6K69_RS10565	COG1012	belongs to the aldehyde dehydrogenase family
B6K69_RS10570	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B6K69_RS10590	COG0848	biopolymer transport protein
B6K69_RS10615	COG0495	leucyl-tRNA aminoacylation
B6K69_RS10650	COG0653	protein targeting
B6K69_RS10655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B6K69_RS10660	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
B6K69_RS10665	COG0494	nUDIX hydrolase
B6K69_RS10670	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B6K69_RS10685	COG0779	Required for maturation of 30S ribosomal subunits
B6K69_RS10700	COG2911	Protein conserved in bacteria
B6K69_RS10725	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B6K69_RS10730	COG1086	Polysaccharide biosynthesis protein
B6K69_RS10750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B6K69_RS10755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B6K69_RS10800	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B6K69_RS10805	COG1132	(ABC) transporter
B6K69_RS10810	COG1132	(ABC) transporter
B6K69_RS10815	COG0617	tRNA 3'-terminal CCA addition
B6K69_RS10830	COG0494	nUDIX hydrolase
B6K69_RS10835	COG0745	RESPONSE REGULATOR receiver
B6K69_RS10845	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B6K69_RS10850	COG0137	argininosuccinate synthase activity
B6K69_RS10865	COG0280	phosphate acetyltransferase
B6K69_RS10865	COG0281	malic enzyme
B6K69_RS10870	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B6K69_RS10875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B6K69_RS10880	COG1420	regulation of RNA biosynthetic process
B6K69_RS10890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B6K69_RS10895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B6K69_RS10910	COG0357	Ribosomal RNA small subunit methyltransferase G
B6K69_RS10915	COG0445	tRNA wobble uridine modification
B6K69_RS10920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B6K69_RS10925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B6K69_RS10930	COG1981	membrane
B6K69_RS10935	COG0424	maF-like protein
B6K69_RS10945	COG0237	dephospho-CoA kinase activity
B6K69_RS10950	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6K69_RS10955	COG1360	Flagellar Motor Protein
B6K69_RS10960	COG1749	Flagellar hook protein flgE
B6K69_RS10975	COG1706	bacterial-type flagellum-dependent cell motility
B6K69_RS10980	COG2003	Belongs to the UPF0758 family
B6K69_RS10990	COG0443	Heat shock 70 kDa protein
B6K69_RS11015	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
B6K69_RS11045	COG2111	Na H antiporter
B6K69_RS11045	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6K69_RS11050	COG1006	Multisubunit Na H antiporter MnhC subunit
B6K69_RS11055	COG0651	ATP synthesis coupled electron transport
B6K69_RS11060	COG1863	multisubunit Na H antiporter MnhE subunit
B6K69_RS11065	COG2212	antiporter activity
B6K69_RS11070	COG1320	monovalent cation:proton antiporter activity
B6K69_RS11075	COG1522	sequence-specific DNA binding
B6K69_RS11080	COG0010	Belongs to the arginase family
B6K69_RS11105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B6K69_RS11120	COG0765	amino acid transport
B6K69_RS11125	COG0765	amino acid transport
B6K69_RS11135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS11140	COG3938	Belongs to the proline racemase family
B6K69_RS11150	COG3938	Belongs to the proline racemase family
B6K69_RS11165	COG4608	Belongs to the ABC transporter superfamily
B6K69_RS11170	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS11175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS11180	COG0601	transmembrane transport
B6K69_RS11185	COG0747	negative chemotaxis
B6K69_RS11195	COG0583	DNA-binding transcription factor activity
B6K69_RS11200	COG0604	alcohol dehydrogenase
B6K69_RS11200	COG3321	synthase
B6K69_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS11215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6K69_RS11215	COG0475	glutathione-regulated potassium exporter activity
B6K69_RS11220	COG1522	sequence-specific DNA binding
B6K69_RS11225	COG0686	Belongs to the AlaDH PNT family
B6K69_RS11230	COG1970	mechanosensitive ion channel activity
B6K69_RS11235	COG0009	L-threonylcarbamoyladenylate synthase
B6K69_RS11240	COG1960	acyl-CoA dehydrogenase activity
B6K69_RS11290	COG2171	N-acyltransferase activity
B6K69_RS11310	COG2951	lytic endotransglycosylase activity
B6K69_RS11315	COG0557	exoribonuclease II activity
B6K69_RS11335	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
B6K69_RS11355	COG1054	Belongs to the UPF0176 family
B6K69_RS11360	COG1335	isochorismatase
B6K69_RS11365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B6K69_RS11370	COG0306	phosphate transporter
B6K69_RS11385	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B6K69_RS11395	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
B6K69_RS11415	COG0514	ATP-dependent DNA helicase (RecQ)
B6K69_RS11425	COG2205	protein histidine kinase activity
B6K69_RS11425	COG0784	Response regulator, receiver
B6K69_RS11425	COG5002	protein histidine kinase activity
B6K69_RS11430	COG2373	Large extracellular alpha-helical protein
B6K69_RS11440	COG0183	Belongs to the thiolase family
B6K69_RS11455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6K69_RS11460	COG0154	amidase activity
B6K69_RS11470	COG1674	ftsk spoiiie
B6K69_RS11495	COG1162	GTPase activity
B6K69_RS11510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B6K69_RS11515	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B6K69_RS11520	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B6K69_RS11525	COG0285	dihydrofolate synthase activity
B6K69_RS11535	COG4372	Transposase
B6K69_RS11540	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS11545	COG2963	transposase activity
B6K69_RS11555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B6K69_RS11565	COG0066	3-isopropylmalate dehydratase activity
B6K69_RS11580	COG0473	3-isopropylmalate dehydrogenase activity
B6K69_RS11585	COG0697	spore germination
B6K69_RS11600	COG1131	(ABC) transporter
B6K69_RS11605	COG0842	Transport permease protein
B6K69_RS11610	COG2423	ornithine cyclodeaminase activity
B6K69_RS11630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
B6K69_RS11635	COG0679	Auxin Efflux Carrier
B6K69_RS11650	COG0799	negative regulation of ribosome biogenesis
B6K69_RS11655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B6K69_RS11660	COG0235	Class ii aldolase
B6K69_RS11690	COG0405	Gamma-glutamyltransferase
B6K69_RS11710	COG3214	Protein conserved in bacteria
B6K69_RS11715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B6K69_RS11740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6K69_RS11750	COG0288	reversible hydration of carbon dioxide
B6K69_RS11760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B6K69_RS11765	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B6K69_RS11770	COG1137	ATPase activity
B6K69_RS11785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B6K69_RS11785	COG0517	IMP dehydrogenase activity
B6K69_RS11815	COG3383	formate dehydrogenase (NAD+) activity
B6K69_RS11820	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B6K69_RS11845	COG1968	undecaprenyl-diphosphatase activity
B6K69_RS11875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B6K69_RS11885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B6K69_RS11890	COG1846	Transcriptional regulator
B6K69_RS11895	COG1764	response to oxidative stress
B6K69_RS11900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B6K69_RS11905	COG1846	Transcriptional regulator
B6K69_RS11910	COG0745	RESPONSE REGULATOR receiver
B6K69_RS11915	COG0123	including yeast histone deacetylase and acetoin utilization protein
B6K69_RS11925	COG0142	geranyltranstransferase activity
B6K69_RS11930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B6K69_RS11935	COG1663	tetraacyldisaccharide 4'-kinase activity
B6K69_RS11940	COG1519	Transferase
B6K69_RS11955	COG0573	inorganic phosphate transmembrane transporter activity
B6K69_RS11965	COG0704	Plays a role in the regulation of phosphate uptake
B6K69_RS11970	COG0330	HflC and HflK could
B6K69_RS11985	COG0284	orotidine-5'-phosphate decarboxylase activity
B6K69_RS11990	COG1940	carbohydrate kinase activity
B6K69_RS11995	COG3142	Participates in the control of copper homeostasis
B6K69_RS12015	COG0628	permease
B6K69_RS12030	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
B6K69_RS12035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B6K69_RS12040	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
B6K69_RS12075	COG4372	Transposase
B6K69_RS12080	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS12090	COG3842	ATPase activity
B6K69_RS12135	COG1132	(ABC) transporter
B6K69_RS12140	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B6K69_RS12145	COG1088	dTDP-glucose 4,6-dehydratase activity
B6K69_RS12150	COG1091	dTDP-4-dehydrorhamnose reductase activity
B6K69_RS12165	COG1216	Glycosyl transferase, family 2
B6K69_RS12165	COG0438	transferase activity, transferring glycosyl groups
B6K69_RS12185	COG0556	nucleotide-excision repair
B6K69_RS12190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B6K69_RS12200	COG0454	-acetyltransferase
B6K69_RS12265	COG1518	maintenance of DNA repeat elements
B6K69_RS12270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
B6K69_RS12275	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B6K69_RS12280	COG4172	Belongs to the ABC transporter superfamily
B6K69_RS12295	COG0747	negative chemotaxis
B6K69_RS12300	COG2267	carboxylic ester hydrolase activity
B6K69_RS12305	COG1492	cobalamin metabolic process
B6K69_RS12310	COG1492	cobalamin metabolic process
B6K69_RS12315	COG1797	cobyrinic acid a,c-diamide synthase activity
B6K69_RS12330	COG2999	glutathione oxidoreductase activity
B6K69_RS12350	COG4948	Mandelate Racemase Muconate Lactonizing
B6K69_RS12355	COG1737	Transcriptional regulator
B6K69_RS12360	COG0747	negative chemotaxis
B6K69_RS12365	COG0601	transmembrane transport
B6K69_RS12370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS12375	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS12400	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B6K69_RS12410	COG0560	Phosphoserine phosphatase
B6K69_RS12435	COG0310	cobalt ion transport
B6K69_RS12455	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
B6K69_RS12465	COG0840	transmembrane signaling receptor activity
B6K69_RS12480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6K69_RS12495	COG2040	homocysteine
B6K69_RS12500	COG0564	pseudouridine synthase activity
B6K69_RS12510	COG2113	Glycine betaine
B6K69_RS12520	COG4176	ABC-type proline glycine betaine transport system permease component
B6K69_RS12580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
B6K69_RS12590	COG3034	peptidoglycan biosynthetic process
B6K69_RS12595	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B6K69_RS12600	COG0242	peptide deformylase activity
B6K69_RS12605	COG0242	peptide deformylase activity
B6K69_RS12610	COG0242	peptide deformylase activity
B6K69_RS12615	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B6K69_RS12630	COG2860	membrane
B6K69_RS12645	COG1280	lysine exporter protein (LysE YggA)
B6K69_RS12655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B6K69_RS12670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B6K69_RS12680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B6K69_RS12705	COG0736	holo-[acyl-carrier-protein] synthase activity
B6K69_RS12710	COG0681	Belongs to the peptidase S26 family
B6K69_RS12715	COG0571	ribonuclease III activity
B6K69_RS12720	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B6K69_RS12765	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B6K69_RS12770	COG0745	RESPONSE REGULATOR receiver
B6K69_RS12775	COG2205	protein histidine kinase activity
B6K69_RS12785	COG1660	Displays ATPase and GTPase activities
B6K69_RS12810	COG1250	3-hydroxyacyl-CoA dehydrogenase
B6K69_RS12825	COG2096	Adenosyltransferase
B6K69_RS12835	COG0300	oxidoreductase activity
B6K69_RS12845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B6K69_RS12860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6K69_RS12880	COG0250	Participates in transcription elongation, termination and antitermination
B6K69_RS12895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B6K69_RS12905	COG0085	RNA polymerase activity
B6K69_RS12910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B6K69_RS12915	COG2072	flavoprotein involved in K transport
B6K69_RS12920	COG0697	spore germination
B6K69_RS12940	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B6K69_RS12950	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B6K69_RS12955	COG0088	Forms part of the polypeptide exit tunnel
B6K69_RS12960	COG0089	rRNA binding
B6K69_RS12965	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B6K69_RS12975	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B6K69_RS12980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B6K69_RS13005	COG0255	Belongs to the universal ribosomal protein uL29 family
B6K69_RS13010	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B6K69_RS13025	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B6K69_RS13030	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B6K69_RS13035	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B6K69_RS13040	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B6K69_RS13045	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B6K69_RS13050	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B6K69_RS13070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B6K69_RS13075	COG0181	hydroxymethylbilane synthase activity
B6K69_RS13090	COG4181	ATPase activity
B6K69_RS13100	COG2353	YceI-like domain
B6K69_RS13105	COG0277	FAD linked oxidase domain protein
B6K69_RS13110	COG0673	inositol 2-dehydrogenase activity
B6K69_RS13130	COG0745	RESPONSE REGULATOR receiver
B6K69_RS13135	COG2205	protein histidine kinase activity
B6K69_RS13170	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
B6K69_RS13175	COG0709	Synthesizes selenophosphate from selenide and ATP
B6K69_RS13210	COG1414	Transcriptional regulator
B6K69_RS13225	COG1012	belongs to the aldehyde dehydrogenase family
B6K69_RS13230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B6K69_RS13240	COG1320	monovalent cation:proton antiporter activity
B6K69_RS13245	COG2212	antiporter activity
B6K69_RS13255	COG0651	ATP synthesis coupled electron transport
B6K69_RS13260	COG1006	Multisubunit Na H antiporter MnhC subunit
B6K69_RS13265	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6K69_RS13265	COG2111	Na H antiporter
B6K69_RS13270	COG1072	(Pantothenic acid kinase))
B6K69_RS13290	COG1940	carbohydrate kinase activity
B6K69_RS13315	COG4638	Rieske (2fe-2S)
B6K69_RS13340	COG0174	glutamine synthetase
B6K69_RS13355	COG0012	GTP binding
B6K69_RS13365	COG0159	tryptophan synthase activity
B6K69_RS13395	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B6K69_RS13400	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B6K69_RS13430	COG1045	serine acetyltransferase
B6K69_RS13440	COG1116	anion transmembrane transporter activity
B6K69_RS13445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6K69_RS13455	COG2358	TRAP transporter, solute receptor (TAXI family
B6K69_RS13460	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B6K69_RS13480	COG0725	ABC transporter, periplasmic molybdate-binding protein
B6K69_RS13485	COG1007	ATP synthesis coupled electron transport
B6K69_RS13495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B6K69_RS13500	COG0713	ATP synthesis coupled electron transport
B6K69_RS13510	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6K69_RS13520	COG1034	ATP synthesis coupled electron transport
B6K69_RS13525	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
B6K69_RS13535	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6K69_RS13535	COG0649	NAD binding
B6K69_RS13545	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
B6K69_RS13555	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
B6K69_RS13590	COG3842	ATPase activity
B6K69_RS13600	COG4771	TonB-dependent receptor
B6K69_RS13615	COG1024	Enoyl-CoA hydratase
B6K69_RS13620	COG1012	belongs to the aldehyde dehydrogenase family
B6K69_RS13625	COG1653	transport
B6K69_RS13630	COG1175	transmembrane transport
B6K69_RS13635	COG0395	ABC-type sugar transport system, permease component
B6K69_RS13640	COG3842	ATPase activity
B6K69_RS13650	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS13670	COG1609	Transcriptional regulator
B6K69_RS13685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6K69_RS13720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B6K69_RS13740	COG0228	four-way junction DNA binding
B6K69_RS13745	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B6K69_RS13755	COG0336	Belongs to the RNA methyltransferase TrmD family
B6K69_RS13765	COG0254	rRNA binding
B6K69_RS13770	COG1192	Involved in chromosome partitioning
B6K69_RS13780	COG0318	PFAM AMP-dependent synthetase and ligase
B6K69_RS13790	COG2358	TRAP transporter, solute receptor (TAXI family
B6K69_RS13805	COG0356	it plays a direct role in the translocation of protons across the membrane
B6K69_RS13810	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B6K69_RS13820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B6K69_RS13830	COG1278	Cold shock
B6K69_RS13850	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
B6K69_RS13855	COG3257	ureidoglycine aminohydrolase activity
B6K69_RS13865	COG2351	hydroxyisourate hydrolase activity
B6K69_RS13915	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6K69_RS13915	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B6K69_RS13930	COG0789	Transcriptional regulator
B6K69_RS13935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B6K69_RS13940	COG3622	Belongs to the hyi family
B6K69_RS13950	COG0714	Associated with various cellular activities
B6K69_RS13975	COG0277	FAD linked oxidase domain protein
B6K69_RS13980	COG0277	FAD linked oxidase domain protein
B6K69_RS13985	COG0247	lactate metabolic process
B6K69_RS13995	COG0071	Belongs to the small heat shock protein (HSP20) family
B6K69_RS14000	COG2304	oxidoreductase activity
B6K69_RS14020	COG0625	glutathione transferase activity
B6K69_RS14075	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B6K69_RS14095	COG0540	Belongs to the ATCase OTCase family
B6K69_RS14105	COG1573	uracil-dna glycosylase
B6K69_RS14110	COG1280	lysine exporter protein (LysE YggA)
B6K69_RS14115	COG0521	Mo-molybdopterin cofactor biosynthetic process
B6K69_RS14125	COG1678	Uncharacterized ACR, COG1678
B6K69_RS14130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B6K69_RS14145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B6K69_RS14165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B6K69_RS14185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B6K69_RS14190	COG0842	Transport permease protein
B6K69_RS14190	COG1129	ABC transporter
B6K69_RS14195	COG0842	Transport permease protein
B6K69_RS14200	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B6K69_RS14205	COG3046	protein related to deoxyribodipyrimidine photolyase
B6K69_RS14215	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B6K69_RS14245	COG2255	four-way junction helicase activity
B6K69_RS14260	COG3045	CreA protein
B6K69_RS14265	COG0824	Thioesterase
B6K69_RS14290	COG2885	chlorophyll binding
B6K69_RS14300	COG0037	tRNA processing
B6K69_RS14305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B6K69_RS14320	COG2759	Belongs to the formate--tetrahydrofolate ligase family
B6K69_RS14325	COG0077	Prephenate dehydratase
B6K69_RS14325	COG1605	Chorismate mutase
B6K69_RS14330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B6K69_RS14345	COG1201	RNA secondary structure unwinding
B6K69_RS14350	COG1692	metallophosphoesterase
B6K69_RS14355	COG0471	metal ion transport
B6K69_RS14355	COG3273	potassium ion transport
B6K69_RS14360	COG0217	transcriptional regulatory protein
B6K69_RS14370	COG0583	DNA-binding transcription factor activity
B6K69_RS14390	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B6K69_RS14405	COG3754	Rhamnan synthesis protein F
B6K69_RS14445	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS14450	COG3585	molybdate ion transport
B6K69_RS14455	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6K69_RS14465	COG1490	D-aminoacyl-tRNA deacylase activity
B6K69_RS14475	COG0318	PFAM AMP-dependent synthetase and ligase
B6K69_RS14480	COG1132	(ABC) transporter
B6K69_RS14495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
B6K69_RS14510	COG4948	Mandelate Racemase Muconate Lactonizing
B6K69_RS14580	COG2267	carboxylic ester hydrolase activity
B6K69_RS14590	COG2983	Belongs to the UPF0260 family
B6K69_RS14595	COG0196	riboflavin kinase activity
B6K69_RS14600	COG2030	dehydratase
B6K69_RS14615	COG1227	inorganic diphosphatase activity
B6K69_RS14620	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B6K69_RS14635	COG3118	belongs to the thioredoxin family
B6K69_RS14645	COG4208	sulfate ABC transporter
B6K69_RS14660	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B6K69_RS14665	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B6K69_RS14670	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
B6K69_RS14675	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B6K69_RS14710	COG0183	Belongs to the thiolase family
B6K69_RS14715	COG0318	PFAM AMP-dependent synthetase and ligase
B6K69_RS14725	COG1309	transcriptional regulator
B6K69_RS14730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B6K69_RS14745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6K69_RS14765	COG3842	ATPase activity
B6K69_RS14770	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6K69_RS14775	COG1177	transmembrane transport
B6K69_RS14785	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
B6K69_RS14800	COG0596	Alpha beta hydrolase
B6K69_RS14810	COG3739	integral membrane protein
B6K69_RS14815	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B6K69_RS14820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B6K69_RS14835	COG0280	phosphate acetyltransferase
B6K69_RS14835	COG0281	malic enzyme
B6K69_RS14845	COG0295	cytidine deaminase activity
B6K69_RS14850	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B6K69_RS14855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B6K69_RS14860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
B6K69_RS14865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B6K69_RS14880	COG0318	PFAM AMP-dependent synthetase and ligase
B6K69_RS14890	COG1435	thymidine kinase activity
B6K69_RS14900	COG0513	Belongs to the DEAD box helicase family
B6K69_RS14905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B6K69_RS14910	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B6K69_RS14910	COG0512	Glutamine amidotransferase of anthranilate synthase
B6K69_RS14935	COG0745	RESPONSE REGULATOR receiver
B6K69_RS14940	COG0346	lactoylglutathione lyase activity
B6K69_RS14960	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B6K69_RS14975	COG1733	regulation of RNA biosynthetic process
B6K69_RS14980	COG0702	epimerase
B6K69_RS15000	COG0424	maF-like protein
B6K69_RS15010	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
B6K69_RS15025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B6K69_RS15035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B6K69_RS15040	COG0667	Aldo Keto reductase
B6K69_RS15085	COG3706	GGDEF domain
B6K69_RS15095	COG0546	phosphoglycolate phosphatase activity
B6K69_RS15120	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
B6K69_RS15125	COG2813	Specifically methylates the guanine in position
B6K69_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS15140	COG0408	coproporphyrinogen oxidase activity
B6K69_RS15180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B6K69_RS15190	COG0789	Transcriptional regulator
B6K69_RS15195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS15200	COG4311	Sarcosine oxidase, delta subunit
B6K69_RS15205	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B6K69_RS15205	COG0446	pyridine nucleotide-disulphide oxidoreductase
B6K69_RS15215	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6K69_RS15235	COG3243	poly(R)-hydroxyalkanoic acid synthase
B6K69_RS15245	COG2267	carboxylic ester hydrolase activity
B6K69_RS15260	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B6K69_RS15265	COG1278	Cold shock
B6K69_RS15285	COG1858	cytochrome C peroxidase
B6K69_RS15295	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B6K69_RS15305	COG1522	sequence-specific DNA binding
B6K69_RS15310	COG1959	2 iron, 2 sulfur cluster binding
B6K69_RS15320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
B6K69_RS15330	COG4208	sulfate ABC transporter
B6K69_RS15335	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
B6K69_RS15365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6K69_RS15380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B6K69_RS15385	COG0151	Belongs to the GarS family
B6K69_RS15390	COG1570	exodeoxyribonuclease VII activity
B6K69_RS15415	COG0552	protein localization to endoplasmic reticulum
B6K69_RS15430	COG2917	probably involved in intracellular septation
B6K69_RS15445	COG1469	GTP cyclohydrolase I activity
B6K69_RS15450	COG3738	Protein conserved in bacteria
B6K69_RS15455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B6K69_RS15460	COG0475	glutathione-regulated potassium exporter activity
B6K69_RS15460	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B6K69_RS15470	COG2968	Membrane
B6K69_RS15485	COG2873	o-acetylhomoserine
B6K69_RS15510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B6K69_RS15515	COG1832	CoA-binding protein
B6K69_RS15520	COG0140	phosphoribosyl-ATP diphosphatase activity
B6K69_RS15525	COG0107	imidazoleglycerol-phosphate synthase activity
B6K69_RS15530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B6K69_RS15540	COG0697	spore germination
B6K69_RS15555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B6K69_RS15560	COG0131	Imidazoleglycerol-phosphate dehydratase
B6K69_RS15570	COG2824	Alkylphosphonate utilization operon protein PhnA
B6K69_RS15575	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B6K69_RS15585	COG0210	DNA helicase
B6K69_RS15590	COG3135	benzoate transporter
B6K69_RS15600	COG0489	protein tyrosine kinase activity
B6K69_RS15615	COG2001	Belongs to the MraZ family
B6K69_RS15635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B6K69_RS15650	COG2951	lytic endotransglycosylase activity
B6K69_RS15655	COG1612	heme a metabolic process
B6K69_RS15660	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B6K69_RS15670	COG1024	Enoyl-CoA hydratase
B6K69_RS15810	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS15815	COG4372	Transposase
B6K69_RS15835	COG1030	water channel activity
B6K69_RS15900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B6K69_RS15925	COG4372	Transposase
B6K69_RS15930	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS15975	COG4974	Belongs to the 'phage' integrase family
B6K69_RS15985	COG3842	ATPase activity
B6K69_RS16010	COG2885	chlorophyll binding
B6K69_RS16015	COG0662	Cupin 2, conserved barrel domain protein
B6K69_RS16050	COG3459	Glycosyltransferase 36 associated
B6K69_RS16070	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS16075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS16080	COG0601	transmembrane transport
B6K69_RS16095	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B6K69_RS16100	COG1518	maintenance of DNA repeat elements
B6K69_RS16115	COG1857	crispr-associated protein
B6K69_RS16140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B6K69_RS16160	COG1012	belongs to the aldehyde dehydrogenase family
B6K69_RS16165	COG1177	transmembrane transport
B6K69_RS16170	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6K69_RS16175	COG3842	ATPase activity
B6K69_RS16180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
B6K69_RS16205	COG1175	transmembrane transport
B6K69_RS16210	COG0395	ABC-type sugar transport system, permease component
B6K69_RS16220	COG3842	ATPase activity
B6K69_RS16225	COG3842	ATPase activity
B6K69_RS16240	COG0673	inositol 2-dehydrogenase activity
B6K69_RS16250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B6K69_RS16300	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
B6K69_RS16320	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B6K69_RS16330	COG0646	methionine synthase
B6K69_RS16330	COG1410	methionine synthase
B6K69_RS16340	COG5012	cobalamin binding
B6K69_RS16350	COG1063	alcohol dehydrogenase
B6K69_RS16370	COG0114	fumarate hydratase activity
B6K69_RS16375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B6K69_RS16395	COG0504	CTP synthase activity
B6K69_RS16425	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
B6K69_RS16430	COG1760	l-serine dehydratase
B6K69_RS16450	COG0330	HflC and HflK could
B6K69_RS16455	COG0330	HflC and HflK could
B6K69_RS16470	COG1418	mRNA catabolic process
B6K69_RS16490	COG0484	heat shock protein binding
B6K69_RS16495	COG1247	-acetyltransferase
B6K69_RS16505	COG0248	Ppx GppA phosphatase
B6K69_RS16510	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
B6K69_RS16520	COG0628	permease
B6K69_RS16540	COG0442	prolyl-tRNA aminoacylation
B6K69_RS16550	COG1858	cytochrome C peroxidase
B6K69_RS16555	COG1272	protein, Hemolysin III
B6K69_RS16570	COG1136	(ABC) transporter
B6K69_RS16585	COG0187	DNA topoisomerase II activity
B6K69_RS16590	COG0625	glutathione transferase activity
B6K69_RS16600	COG2326	polyphosphate kinase activity
B6K69_RS16615	COG0534	Mate efflux family protein
B6K69_RS16645	COG1329	Transcriptional regulator
B6K69_RS16650	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
B6K69_RS16655	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B6K69_RS16685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B6K69_RS16690	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B6K69_RS16700	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
B6K69_RS16705	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
B6K69_RS16715	COG0752	glycyl-tRNA synthetase alpha subunit
B6K69_RS16725	COG0751	glycine-tRNA ligase activity
B6K69_RS16730	COG0574	Belongs to the PEP-utilizing enzyme family
B6K69_RS16730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B6K69_RS16740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B6K69_RS16750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B6K69_RS16755	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B6K69_RS16765	COG4948	Mandelate Racemase Muconate Lactonizing
B6K69_RS16770	COG1522	sequence-specific DNA binding
B6K69_RS16785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B6K69_RS16800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B6K69_RS16815	COG1802	Transcriptional regulator
B6K69_RS16825	COG0505	Belongs to the CarA family
B6K69_RS16830	COG1610	YqeY-like protein
B6K69_RS16835	COG1742	UPF0060 membrane protein
B6K69_RS16850	COG3474	cytochrome
B6K69_RS16870	COG3842	ATPase activity
B6K69_RS16880	COG1176	ABC-type spermidine putrescine transport system, permease component I
B6K69_RS16885	COG1177	transmembrane transport
B6K69_RS16895	COG0321	lipoyl(octanoyl) transferase activity
B6K69_RS16895	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B6K69_RS16900	COG0084	hydrolase, TatD family'
B6K69_RS16910	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B6K69_RS16915	COG1686	Belongs to the peptidase S11 family
B6K69_RS16930	COG2207	Transcriptional regulator
B6K69_RS16945	COG0604	alcohol dehydrogenase
B6K69_RS16955	COG0415	Belongs to the DNA photolyase family
B6K69_RS16960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
B6K69_RS16970	COG0494	nUDIX hydrolase
B6K69_RS16995	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
B6K69_RS16995	COG3264	Mechanosensitive ion channel
B6K69_RS17000	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B6K69_RS17025	COG0310	cobalt ion transport
B6K69_RS17050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
B6K69_RS17060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6K69_RS17060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B6K69_RS17080	COG3585	molybdate ion transport
B6K69_RS17105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B6K69_RS17115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B6K69_RS17125	COG0469	pyruvate kinase activity
B6K69_RS17140	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B6K69_RS17160	COG1215	transferase activity, transferring glycosyl groups
B6K69_RS17170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B6K69_RS17175	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
B6K69_RS17180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B6K69_RS17185	COG4558	Periplasmic binding protein
B6K69_RS17190	COG3720	iron ion transport
B6K69_RS17220	COG1918	ferrous iron import across plasma membrane
B6K69_RS17235	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B6K69_RS17255	COG3639	organic phosphonate transmembrane transporter activity
B6K69_RS17265	COG2188	Transcriptional regulator
B6K69_RS17270	COG3624	Phosphonate C-P lyase system protein PhnG
B6K69_RS17275	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
B6K69_RS17280	COG0583	DNA-binding transcription factor activity
B6K69_RS17285	COG0022	dehydrogenase e1 component
B6K69_RS17290	COG0508	dehydrogenase complex catalyzes the overall conversion of
B6K69_RS17295	COG1028	Short-chain dehydrogenase reductase Sdr
B6K69_RS17325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B6K69_RS17345	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS17355	COG4372	Transposase
B6K69_RS17360	COG3436	PFAM IS66 Orf2 family protein
B6K69_RS17390	COG3831	ATPase activity
B6K69_RS17415	COG1401	restriction endodeoxyribonuclease activity
B6K69_RS17455	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
B6K69_RS17460	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B6K69_RS17475	COG0587	DNA-directed DNA polymerase activity
B6K69_RS17495	COG2336	PFAM SpoVT AbrB
B6K69_RS17500	COG2337	Toxic component of a toxin-antitoxin (TA) module
B6K69_RS17550	COG2255	four-way junction helicase activity
B6K69_RS17575	COG1074	ATP-dependent DNA helicase activity
B6K69_RS17600	COG3177	Filamentation induced by cAMP protein fic
B6K69_RS17605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B6K69_RS17645	COG1192	Involved in chromosome partitioning
B6K69_RS17650	COG1475	DNA binding
B6K69_RS17655	COG1414	Transcriptional regulator
B6K69_RS17670	COG1396	sequence-specific DNA binding
B6K69_RS17670	COG1917	Cupin 2, conserved barrel domain protein
B6K69_RS17675	COG0747	negative chemotaxis
B6K69_RS17680	COG0601	transmembrane transport
B6K69_RS17685	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B6K69_RS17690	COG0444	Belongs to the ABC transporter superfamily
B6K69_RS17695	COG4608	Belongs to the ABC transporter superfamily
B6K69_RS17710	COG1215	transferase activity, transferring glycosyl groups
B6K69_RS17730	COG2011	ABC-type metal ion transport system permease component
B6K69_RS17735	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B6K69_RS17740	COG1464	Belongs to the NlpA lipoprotein family
B6K69_RS17760	COG0246	Mannitol dehydrogenase
B6K69_RS17765	COG1312	Catalyzes the dehydration of D-mannonate
B6K69_RS17770	COG1063	alcohol dehydrogenase
B6K69_RS17775	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
B6K69_RS17785	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B6K69_RS17795	COG1283	sodium-dependent phosphate transmembrane transporter activity
B6K69_RS17800	COG0406	alpha-ribazole phosphatase activity
B6K69_RS17805	COG3842	ATPase activity
B6K69_RS17835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B6K69_RS17845	COG0438	transferase activity, transferring glycosyl groups
B6K69_RS17925	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B6K69_RS17935	COG1028	Short-chain dehydrogenase reductase Sdr