locus-tag	class	description
O5Y_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O5Y_RS00010	COG0592	DNA-directed DNA polymerase activity
O5Y_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
O5Y_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
O5Y_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
O5Y_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O5Y_RS00105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O5Y_RS00110	COG0705	Rhomboid family
O5Y_RS00110	COG0457	Tetratricopeptide repeat
O5Y_RS00130	COG0277	FAD linked oxidase domain protein
O5Y_RS00150	COG3879	Bacterial protein of unknown function (DUF881)
O5Y_RS00160	COG0515	serine threonine protein kinase
O5Y_RS00160	COG2815	serine threonine protein kinase
O5Y_RS00165	COG0515	serine threonine protein kinase
O5Y_RS00170	COG0768	penicillin binding
O5Y_RS00185	COG1716	ATPase activity
O5Y_RS00190	COG1716	ATPase activity
O5Y_RS00280	COG0070	glutamate synthase
O5Y_RS00280	COG0069	glutamate synthase activity
O5Y_RS00280	COG0067	glutamate synthase
O5Y_RS00290	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
O5Y_RS00330	COG0025	NhaP-type Na H and K H
O5Y_RS00340	COG0601	transmembrane transport
O5Y_RS00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS00350	COG0444	Belongs to the ABC transporter superfamily
O5Y_RS00365	COG2199	diguanylate cyclase activity
O5Y_RS00375	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O5Y_RS00375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O5Y_RS00380	COG2501	S4 domain
O5Y_RS00385	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
O5Y_RS00405	COG2365	Tyrosine phosphatase family
O5Y_RS00440	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS00455	COG4716	Myosin-crossreactive antigen
O5Y_RS00470	COG2271	Major facilitator Superfamily
O5Y_RS00510	COG2197	response regulator
O5Y_RS00525	COG1136	(ABC) transporter
O5Y_RS00525	COG0577	efflux transmembrane transporter activity
O5Y_RS00575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS00580	COG1120	ATPase activity
O5Y_RS00615	COG2318	DinB family
O5Y_RS00640	COG3119	arylsulfatase activity
O5Y_RS00650	COG0175	sulfate reduction
O5Y_RS00655	COG4424	Sulfotransferase
O5Y_RS00690	COG5001	Diguanylate cyclase
O5Y_RS00710	COG1403	HNH endonuclease
O5Y_RS00730	COG0183	Belongs to the thiolase family
O5Y_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS00750	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS00755	COG0154	amidase activity
O5Y_RS00785	COG0154	amidase activity
O5Y_RS00795	COG2271	Major facilitator Superfamily
O5Y_RS00805	COG2119	membrane
O5Y_RS00825	COG0628	permease
O5Y_RS00835	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O5Y_RS00845	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O5Y_RS00855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS00885	COG1528	Iron-storage protein
O5Y_RS00920	COG1528	Iron-storage protein
O5Y_RS00930	COG1316	TRANSCRIPTIONal
O5Y_RS01015	COG0204	Acyl-transferase
O5Y_RS01025	COG0561	phosphatase activity
O5Y_RS01035	COG2385	sporulation resulting in formation of a cellular spore
O5Y_RS01045	COG1113	amino acid transport
O5Y_RS01050	COG0183	Belongs to the thiolase family
O5Y_RS01055	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS01060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS01070	COG1216	Glycosyl transferase, family 2
O5Y_RS01080	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
O5Y_RS01085	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O5Y_RS01090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS01095	COG5479	isomerase activity
O5Y_RS01095	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS01105	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
O5Y_RS01115	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS01120	COG3321	synthase
O5Y_RS01120	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
O5Y_RS01120	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O5Y_RS01125	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5Y_RS01185	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS01190	COG0277	FAD linked oxidase domain protein
O5Y_RS01215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O5Y_RS01220	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
O5Y_RS01225	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
O5Y_RS01240	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
O5Y_RS01245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O5Y_RS01250	COG0673	inositol 2-dehydrogenase activity
O5Y_RS01260	COG1215	transferase activity, transferring glycosyl groups
O5Y_RS01265	COG1216	Glycosyl transferase, family 2
O5Y_RS01275	COG1162	GTPase activity
O5Y_RS01280	COG1216	Glycosyl transferase, family 2
O5Y_RS01430	COG0831	urea catabolic process
O5Y_RS01440	COG0804	urea catabolic process
O5Y_RS01445	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
O5Y_RS01455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O5Y_RS01465	COG4413	Urea transporter
O5Y_RS01470	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O5Y_RS01485	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS01495	COG0737	Belongs to the 5'-nucleotidase family
O5Y_RS01500	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O5Y_RS01520	COG4977	sequence-specific DNA binding
O5Y_RS01530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS01535	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS01540	COG1120	ATPase activity
O5Y_RS01575	COG0270	DNA (cytosine-5-)-methyltransferase activity
O5Y_RS01585	COG0287	Prephenate dehydrogenase
O5Y_RS01595	COG0590	tRNA wobble adenosine to inosine editing
O5Y_RS01620	COG2149	membrane
O5Y_RS01640	COG3706	GGDEF domain
O5Y_RS01650	COG2409	Drug exporters of the RND superfamily
O5Y_RS01670	COG0343	queuine tRNA-ribosyltransferase activity
O5Y_RS01680	COG5473	translation initiation factor activity
O5Y_RS01695	COG3300	MHYT domain
O5Y_RS01695	COG5001	Diguanylate cyclase
O5Y_RS01700	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O5Y_RS01705	COG3226	Transcriptional regulator
O5Y_RS01735	COG0745	RESPONSE REGULATOR receiver
O5Y_RS01745	COG1357	PFAM Pentapeptide repeats (8 copies)
O5Y_RS01770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS01785	COG0583	DNA-binding transcription factor activity
O5Y_RS01790	COG2855	membrane
O5Y_RS01805	COG2175	clavaminate synthase activity
O5Y_RS01810	COG3246	L-lysine catabolic process to acetate
O5Y_RS01815	COG2814	Major facilitator Superfamily
O5Y_RS01825	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS01855	COG2132	Multicopper oxidase
O5Y_RS01860	COG0183	Belongs to the thiolase family
O5Y_RS01875	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5Y_RS01900	COG0860	N-Acetylmuramoyl-L-alanine amidase
O5Y_RS01905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
O5Y_RS01910	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
O5Y_RS01915	COG1309	transcriptional regulator
O5Y_RS01920	COG2814	Major facilitator Superfamily
O5Y_RS01925	COG1309	transcriptional regulator
O5Y_RS01945	COG0183	Belongs to the thiolase family
O5Y_RS01960	COG0183	Belongs to the thiolase family
O5Y_RS01965	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS01970	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS01975	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS01990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O5Y_RS01995	COG0697	spore germination
O5Y_RS02000	COG0583	DNA-binding transcription factor activity
O5Y_RS02010	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O5Y_RS02070	COG2132	Multicopper oxidase
O5Y_RS02075	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS02080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O5Y_RS02095	COG4585	Histidine kinase
O5Y_RS02100	COG4566	intracellular signal transduction
O5Y_RS02135	COG0546	phosphoglycolate phosphatase activity
O5Y_RS02140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS02145	COG2205	protein histidine kinase activity
O5Y_RS02185	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS02210	COG1408	metallophosphoesterase
O5Y_RS02245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS02265	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
O5Y_RS02275	COG0477	Major facilitator Superfamily
O5Y_RS02280	COG0583	DNA-binding transcription factor activity
O5Y_RS02290	COG1309	transcriptional regulator
O5Y_RS02320	COG0494	nUDIX hydrolase
O5Y_RS02330	COG0596	Alpha beta hydrolase
O5Y_RS02340	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
O5Y_RS02345	COG0477	Major facilitator Superfamily
O5Y_RS02360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5Y_RS02380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O5Y_RS02390	COG0601	transmembrane transport
O5Y_RS02395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS02400	COG4172	Belongs to the ABC transporter superfamily
O5Y_RS02450	COG1111	helicase
O5Y_RS02450	COG1205	dead DEAH box helicase
O5Y_RS02455	COG1278	Cold shock
O5Y_RS02465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
O5Y_RS02465	COG1754	DNA topoisomerase type I activity
O5Y_RS02470	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
O5Y_RS02480	COG1714	RDD family
O5Y_RS02510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS02515	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O5Y_RS02540	COG1802	Transcriptional regulator
O5Y_RS02550	COG2268	Band 7 protein
O5Y_RS02590	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS02665	COG0477	Major facilitator Superfamily
O5Y_RS02705	COG1937	Protein conserved in bacteria
O5Y_RS02725	COG2226	methyltransferase
O5Y_RS02735	COG1396	sequence-specific DNA binding
O5Y_RS02740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5Y_RS02770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O5Y_RS02775	COG0442	prolyl-tRNA aminoacylation
O5Y_RS02785	COG1309	transcriptional regulator
O5Y_RS02795	COG1285	pathogenesis
O5Y_RS02840	COG1358	cellular component organization or biogenesis
O5Y_RS02855	COG2755	lipolytic protein G-D-S-L family
O5Y_RS02920	COG0561	phosphatase activity
O5Y_RS02950	COG1316	TRANSCRIPTIONal
O5Y_RS02965	COG2027	D-alanyl-D-alanine carboxypeptidase
O5Y_RS02975	COG0037	tRNA processing
O5Y_RS03000	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS03010	COG2186	Transcriptional regulator
O5Y_RS03015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O5Y_RS03020	COG0302	gtp cyclohydrolase
O5Y_RS03055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
O5Y_RS03060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
O5Y_RS03065	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
O5Y_RS03095	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
O5Y_RS03135	COG1024	Enoyl-CoA hydratase
O5Y_RS03145	COG1309	transcriptional regulator
O5Y_RS03165	COG4585	Histidine kinase
O5Y_RS03170	COG2197	response regulator
O5Y_RS03215	COG0596	Alpha beta hydrolase
O5Y_RS03240	COG1194	a g-specific adenine glycosylase
O5Y_RS03280	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS03290	COG0288	reversible hydration of carbon dioxide
O5Y_RS03300	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
O5Y_RS03310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
O5Y_RS03320	COG1329	Transcriptional regulator
O5Y_RS03325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
O5Y_RS03330	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
O5Y_RS03335	COG0215	cysteine-tRNA ligase activity
O5Y_RS03340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O5Y_RS03345	COG1132	(ABC) transporter
O5Y_RS03360	COG2207	Transcriptional regulator
O5Y_RS03380	COG1984	allophanate hydrolase subunit 2
O5Y_RS03385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
O5Y_RS03390	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
O5Y_RS03395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O5Y_RS03400	COG1121	(ABC) transporter
O5Y_RS03405	COG0803	Belongs to the bacterial solute-binding protein 9 family
O5Y_RS03410	COG1609	Transcriptional regulator
O5Y_RS03420	COG1309	transcriptional regulator
O5Y_RS03425	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03430	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03435	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03510	COG2890	protein-(glutamine-N5) methyltransferase activity
O5Y_RS03525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
O5Y_RS03535	COG1136	(ABC) transporter
O5Y_RS03550	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
O5Y_RS03575	COG2030	dehydratase
O5Y_RS03580	COG1053	succinate dehydrogenase
O5Y_RS03590	COG3971	2-oxopent-4-enoate hydratase activity
O5Y_RS03595	COG4569	acetaldehyde dehydrogenase (acetylating) activity
O5Y_RS03600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O5Y_RS03630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5Y_RS03670	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03675	COG2267	carboxylic ester hydrolase activity
O5Y_RS03680	COG0346	lactoylglutathione lyase activity
O5Y_RS03685	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O5Y_RS03700	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O5Y_RS03710	COG2814	Major facilitator Superfamily
O5Y_RS03720	COG4689	acetoacetate decarboxylase
O5Y_RS03725	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS03730	COG2124	cytochrome p450
O5Y_RS03760	COG1253	flavin adenine dinucleotide binding
O5Y_RS03780	COG1116	anion transmembrane transporter activity
O5Y_RS03790	COG1074	ATP-dependent DNA helicase activity
O5Y_RS03810	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
O5Y_RS03820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5Y_RS03840	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
O5Y_RS03865	COG0656	L-ascorbic acid biosynthetic process
O5Y_RS03870	COG0686	Belongs to the AlaDH PNT family
O5Y_RS03890	COG0346	lactoylglutathione lyase activity
O5Y_RS03900	COG0561	phosphatase activity
O5Y_RS03920	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03925	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03930	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03935	COG1024	Enoyl-CoA hydratase
O5Y_RS03940	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS03945	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS03950	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS03955	COG1309	transcriptional regulator
O5Y_RS03960	COG0183	Belongs to the thiolase family
O5Y_RS04050	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS04065	COG3214	Protein conserved in bacteria
O5Y_RS04075	COG1414	Transcriptional regulator
O5Y_RS04095	COG1024	Enoyl-CoA hydratase
O5Y_RS04100	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS04120	COG0183	Belongs to the thiolase family
O5Y_RS04125	COG2124	cytochrome p450
O5Y_RS04145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O5Y_RS04150	COG0183	Belongs to the thiolase family
O5Y_RS04160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS04180	COG2070	2-Nitropropane dioxygenase
O5Y_RS04185	COG2186	Transcriptional regulator
O5Y_RS04190	COG4608	Belongs to the ABC transporter superfamily
O5Y_RS04195	COG0444	Belongs to the ABC transporter superfamily
O5Y_RS04200	COG0601	transmembrane transport
O5Y_RS04205	COG0747	negative chemotaxis
O5Y_RS04215	COG0673	inositol 2-dehydrogenase activity
O5Y_RS04220	COG0673	inositol 2-dehydrogenase activity
O5Y_RS04225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O5Y_RS04230	COG1940	carbohydrate kinase activity
O5Y_RS04245	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O5Y_RS04255	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS04260	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS04265	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS04285	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS04310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O5Y_RS04330	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
O5Y_RS04335	COG1132	(ABC) transporter
O5Y_RS04340	COG1132	(ABC) transporter
O5Y_RS04355	COG1937	Protein conserved in bacteria
O5Y_RS04365	COG2409	Drug exporters of the RND superfamily
O5Y_RS04415	COG2076	Multidrug Resistance protein
O5Y_RS04430	COG0745	RESPONSE REGULATOR receiver
O5Y_RS04435	COG2205	protein histidine kinase activity
O5Y_RS04455	COG2271	Major facilitator Superfamily
O5Y_RS04460	COG3483	tryptophan 2,3-dioxygenase activity
O5Y_RS04475	COG4948	Mandelate Racemase Muconate Lactonizing
O5Y_RS04495	COG0537	adenosine 5'-monophosphoramidase activity
O5Y_RS04505	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O5Y_RS04525	COG0444	Belongs to the ABC transporter superfamily
O5Y_RS04530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS04535	COG0601	transmembrane transport
O5Y_RS04575	COG0671	phosphoesterase, PA-phosphatase related
O5Y_RS04580	COG0745	RESPONSE REGULATOR receiver
O5Y_RS04585	COG2205	protein histidine kinase activity
O5Y_RS04605	COG0436	Aminotransferase
O5Y_RS04615	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O5Y_RS04625	COG2382	esterase
O5Y_RS04630	COG4592	Periplasmic binding protein
O5Y_RS04635	COG4585	Histidine kinase
O5Y_RS04640	COG2197	response regulator
O5Y_RS04645	COG2365	Tyrosine phosphatase family
O5Y_RS04655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
O5Y_RS04665	COG4565	transcriptional regulatory protein
O5Y_RS04670	COG3290	protein histidine kinase activity
O5Y_RS04675	COG1301	dicarboxylic acid transport
O5Y_RS04695	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS04700	COG0386	Belongs to the glutathione peroxidase family
O5Y_RS04720	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O5Y_RS04725	COG0047	phosphoribosylformylglycinamidine synthase activity
O5Y_RS04735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS04755	COG2205	protein histidine kinase activity
O5Y_RS04760	COG0745	RESPONSE REGULATOR receiver
O5Y_RS04770	COG2217	Heavy metal translocating P-type atpase
O5Y_RS04785	COG0488	(ABC) transporter
O5Y_RS04810	COG3104	oligopeptide transport
O5Y_RS04825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O5Y_RS04850	COG4585	Histidine kinase
O5Y_RS04855	COG2197	response regulator
O5Y_RS04875	COG1309	transcriptional regulator
O5Y_RS04885	COG2409	Drug exporters of the RND superfamily
O5Y_RS04895	COG0220	tRNA (guanine-N7-)-methyltransferase activity
O5Y_RS04915	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
O5Y_RS04925	COG1045	serine acetyltransferase
O5Y_RS04930	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
O5Y_RS04950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS04955	COG1120	ATPase activity
O5Y_RS04985	COG1940	carbohydrate kinase activity
O5Y_RS04990	COG0500	methyltransferase
O5Y_RS05020	COG4981	capsule polysaccharide biosynthetic process
O5Y_RS05035	COG1472	Belongs to the glycosyl hydrolase 3 family
O5Y_RS05040	COG1309	transcriptional regulator
O5Y_RS05045	COG2030	dehydratase
O5Y_RS05050	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS05055	COG0183	Belongs to the thiolase family
O5Y_RS05065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS05075	COG1476	TRANSCRIPTIONal
O5Y_RS05100	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS05115	COG1136	(ABC) transporter
O5Y_RS05115	COG0577	efflux transmembrane transporter activity
O5Y_RS05120	COG4585	Histidine kinase
O5Y_RS05125	COG2197	response regulator
O5Y_RS05150	COG2267	carboxylic ester hydrolase activity
O5Y_RS05180	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O5Y_RS05195	COG0009	L-threonylcarbamoyladenylate synthase
O5Y_RS05205	COG0659	secondary active sulfate transmembrane transporter activity
O5Y_RS05270	COG2837	iron assimilation
O5Y_RS05305	COG0501	Belongs to the peptidase M48B family
O5Y_RS05320	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O5Y_RS05330	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
O5Y_RS05365	COG3707	response regulator
O5Y_RS05370	COG0596	Alpha beta hydrolase
O5Y_RS05420	COG1120	ATPase activity
O5Y_RS05425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS05430	COG2226	methyltransferase
O5Y_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS05465	COG0628	permease
O5Y_RS05490	COG0183	Belongs to the thiolase family
O5Y_RS05520	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O5Y_RS05530	COG0477	Major facilitator Superfamily
O5Y_RS05535	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
O5Y_RS05540	COG1737	Transcriptional regulator
O5Y_RS05545	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
O5Y_RS05580	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
O5Y_RS05595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O5Y_RS05625	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O5Y_RS05635	COG0833	amino acid
O5Y_RS05640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O5Y_RS05665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5Y_RS05675	COG0156	8-amino-7-oxononanoate synthase activity
O5Y_RS05700	COG0277	FAD linked oxidase domain protein
O5Y_RS05715	COG1053	succinate dehydrogenase
O5Y_RS05720	COG0739	heme binding
O5Y_RS05765	COG1131	(ABC) transporter
O5Y_RS05770	COG2188	Transcriptional regulator
O5Y_RS05790	COG0717	Belongs to the dCTP deaminase family
O5Y_RS05810	COG1414	Transcriptional regulator
O5Y_RS05860	COG2890	protein-(glutamine-N5) methyltransferase activity
O5Y_RS05875	COG1278	Cold shock
O5Y_RS05925	COG0783	Belongs to the Dps family
O5Y_RS05930	COG0789	Transcriptional regulator
O5Y_RS05965	COG1595	DNA-templated transcription, initiation
O5Y_RS05970	COG1302	Protein conserved in bacteria
O5Y_RS06035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O5Y_RS06050	COG1215	transferase activity, transferring glycosyl groups
O5Y_RS06080	COG0297	glycogen (starch) synthase activity
O5Y_RS06100	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
O5Y_RS06105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O5Y_RS06110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O5Y_RS06115	COG0489	protein tyrosine kinase activity
O5Y_RS06150	COG0297	glycogen (starch) synthase activity
O5Y_RS06155	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
O5Y_RS06160	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
O5Y_RS06165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O5Y_RS06170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O5Y_RS06175	COG0489	protein tyrosine kinase activity
O5Y_RS06180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O5Y_RS06185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
O5Y_RS06190	COG0443	Heat shock 70 kDa protein
O5Y_RS06205	COG1506	peptidase
O5Y_RS06205	COG4946	Tricorn protease homolog
O5Y_RS06205	COG0823	Involved in the tonB-independent uptake of proteins
O5Y_RS06225	COG0247	lactate metabolic process
O5Y_RS06225	COG2181	nitrate reductase activity
O5Y_RS06275	COG0477	Major facilitator Superfamily
O5Y_RS06280	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
O5Y_RS06295	COG0443	Heat shock 70 kDa protein
O5Y_RS06300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O5Y_RS06305	COG0484	heat shock protein binding
O5Y_RS06310	COG0789	Transcriptional regulator
O5Y_RS06355	COG2072	flavoprotein involved in K transport
O5Y_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS06380	COG1053	succinate dehydrogenase
O5Y_RS06380	COG3976	FMN-binding domain protein
O5Y_RS06415	COG3631	Ketosteroid isomerase-related protein
O5Y_RS06420	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O5Y_RS06430	COG1414	Transcriptional regulator
O5Y_RS06455	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS06465	COG3290	protein histidine kinase activity
O5Y_RS06475	COG2851	Citrate transporter
O5Y_RS06500	COG0542	response to heat
O5Y_RS06525	COG2814	Major facilitator Superfamily
O5Y_RS06535	COG1309	transcriptional regulator
O5Y_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS06575	COG0596	Alpha beta hydrolase
O5Y_RS06585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS06590	COG0523	cobalamin synthesis protein
O5Y_RS06595	COG0586	Pfam SNARE associated Golgi protein
O5Y_RS06620	COG4129	membrane
O5Y_RS06640	COG2354	Protein conserved in bacteria
O5Y_RS06645	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O5Y_RS06675	COG1994	Peptidase M50
O5Y_RS06685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O5Y_RS06700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS06710	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS06730	COG3706	GGDEF domain
O5Y_RS06735	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
O5Y_RS06760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
O5Y_RS06785	COG0681	Belongs to the peptidase S26 family
O5Y_RS06815	COG1126	abc transporter atp-binding protein
O5Y_RS06820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O5Y_RS06835	COG0747	negative chemotaxis
O5Y_RS06845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS06850	COG4172	Belongs to the ABC transporter superfamily
O5Y_RS06855	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS06870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS06875	COG0037	tRNA processing
O5Y_RS06875	COG0590	tRNA wobble adenosine to inosine editing
O5Y_RS06895	COG2149	membrane
O5Y_RS06900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS06910	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
O5Y_RS06920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O5Y_RS06935	COG0352	thiamine-phosphate diphosphorylase activity
O5Y_RS06940	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5Y_RS06940	COG2022	thiamine diphosphate biosynthetic process
O5Y_RS06950	COG2022	thiamine diphosphate biosynthetic process
O5Y_RS06955	COG1131	(ABC) transporter
O5Y_RS06965	COG2234	aminopeptidase activity
O5Y_RS06975	COG0351	phosphomethylpyrimidine kinase
O5Y_RS06980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
O5Y_RS06995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O5Y_RS06995	COG0456	acetyltransferase
O5Y_RS07020	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O5Y_RS07030	COG1320	monovalent cation:proton antiporter activity
O5Y_RS07040	COG1863	multisubunit Na H antiporter MnhE subunit
O5Y_RS07045	COG0651	ATP synthesis coupled electron transport
O5Y_RS07050	COG1006	Multisubunit Na H antiporter MnhC subunit
O5Y_RS07055	COG2111	Na H antiporter
O5Y_RS07055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
O5Y_RS07085	COG2124	cytochrome p450
O5Y_RS07110	COG1228	amidohydrolase
O5Y_RS07115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
O5Y_RS07120	COG1183	phosphatidylcholine synthase activity
O5Y_RS07125	COG0688	phosphatidylethanolamine metabolic process
O5Y_RS07150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
O5Y_RS07155	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
O5Y_RS07155	COG2508	Transcriptional regulator
O5Y_RS07170	COG0459	protein refolding
O5Y_RS07200	COG2326	polyphosphate kinase activity
O5Y_RS07205	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O5Y_RS07210	COG1505	serine-type exopeptidase activity
O5Y_RS07240	COG1733	regulation of RNA biosynthetic process
O5Y_RS07245	COG0702	epimerase
O5Y_RS07265	COG1802	Transcriptional regulator
O5Y_RS07275	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS07285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS07310	COG1802	Transcriptional regulator
O5Y_RS07340	COG1309	transcriptional regulator
O5Y_RS07350	COG1172	Belongs to the binding-protein-dependent transport system permease family
O5Y_RS07360	COG1137	ATPase activity
O5Y_RS07370	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS07405	COG2224	Isocitrate lyase
O5Y_RS07415	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O5Y_RS07420	COG1064	alcohol dehydrogenase
O5Y_RS07445	COG0297	glycogen (starch) synthase activity
O5Y_RS07465	COG2326	polyphosphate kinase activity
O5Y_RS07475	COG2733	membrane
O5Y_RS07495	COG0596	Alpha beta hydrolase
O5Y_RS07500	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5Y_RS07505	COG2271	Major facilitator Superfamily
O5Y_RS07525	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
O5Y_RS07565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
O5Y_RS07610	COG0583	DNA-binding transcription factor activity
O5Y_RS07625	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O5Y_RS07640	COG0438	transferase activity, transferring glycosyl groups
O5Y_RS07650	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS07660	COG5002	protein histidine kinase activity
O5Y_RS07665	COG0745	RESPONSE REGULATOR receiver
O5Y_RS07750	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
O5Y_RS07755	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
O5Y_RS07760	COG0181	hydroxymethylbilane synthase activity
O5Y_RS07765	COG1587	Uroporphyrinogen-III synthase
O5Y_RS07765	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O5Y_RS07795	COG1937	Protein conserved in bacteria
O5Y_RS07805	COG1218	3'(2'),5'-bisphosphate nucleotidase
O5Y_RS07810	COG0175	sulfate reduction
O5Y_RS07825	COG4221	oxidoreductase activity
O5Y_RS07840	COG0747	negative chemotaxis
O5Y_RS07845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS07870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
O5Y_RS07875	COG0406	alpha-ribazole phosphatase activity
O5Y_RS07885	COG0785	Cytochrome C biogenesis protein
O5Y_RS07895	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O5Y_RS07920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
O5Y_RS07940	COG0542	response to heat
O5Y_RS07945	COG1950	PFAM Membrane protein of
O5Y_RS08005	COG0559	Belongs to the binding-protein-dependent transport system permease family
O5Y_RS08015	COG0410	ABC transporter
O5Y_RS08040	COG4948	Mandelate Racemase Muconate Lactonizing
O5Y_RS08055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
O5Y_RS08060	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
O5Y_RS08070	COG0438	transferase activity, transferring glycosyl groups
O5Y_RS08080	COG0644	oxidoreductase
O5Y_RS08085	COG0142	geranyltranstransferase activity
O5Y_RS08090	COG0501	Belongs to the peptidase M48B family
O5Y_RS08095	COG1666	GTP binding
O5Y_RS08115	COG0267	Belongs to the bacterial ribosomal protein bL33 family
O5Y_RS08120	COG2030	dehydratase
O5Y_RS08145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
O5Y_RS08150	COG0081	regulation of translation
O5Y_RS08175	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS08180	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS08205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O5Y_RS08225	COG0085	RNA polymerase activity
O5Y_RS08230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
O5Y_RS08240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS08260	COG0604	alcohol dehydrogenase
O5Y_RS08270	COG0604	alcohol dehydrogenase
O5Y_RS08280	COG0477	Major facilitator Superfamily
O5Y_RS08285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS08305	COG5006	permease, DMT superfamily
O5Y_RS08310	COG1024	Enoyl-CoA hydratase
O5Y_RS08325	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS08330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5Y_RS08365	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
O5Y_RS08370	COG0049	tRNA binding
O5Y_RS08375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
O5Y_RS08380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
O5Y_RS08475	COG1454	alcohol dehydrogenase
O5Y_RS08480	COG4585	Histidine kinase
O5Y_RS08500	COG1131	(ABC) transporter
O5Y_RS08505	COG3559	Exporter of polyketide antibiotics
O5Y_RS08545	COG0535	radical SAM domain protein
O5Y_RS08560	COG1902	pentaerythritol trinitrate reductase activity
O5Y_RS08560	COG0446	pyridine nucleotide-disulphide oxidoreductase
O5Y_RS08570	COG0446	pyridine nucleotide-disulphide oxidoreductase
O5Y_RS08570	COG1902	pentaerythritol trinitrate reductase activity
O5Y_RS08610	COG0531	amino acid
O5Y_RS08615	COG4303	Ethanolamine ammonia lyase large subunit
O5Y_RS08635	COG0477	Major facilitator Superfamily
O5Y_RS08640	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS08645	COG3284	Transcriptional regulator
O5Y_RS08650	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS08665	COG2409	Drug exporters of the RND superfamily
O5Y_RS08680	COG1216	Glycosyl transferase, family 2
O5Y_RS08685	COG1301	dicarboxylic acid transport
O5Y_RS08695	COG2357	RelA SpoT domain protein
O5Y_RS08700	COG1309	transcriptional regulator
O5Y_RS08705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5Y_RS08715	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS08720	COG2030	dehydratase
O5Y_RS08750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O5Y_RS08760	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS08760	COG5479	isomerase activity
O5Y_RS08780	COG1215	transferase activity, transferring glycosyl groups
O5Y_RS08790	COG0287	Prephenate dehydrogenase
O5Y_RS08795	COG0512	Glutamine amidotransferase of anthranilate synthase
O5Y_RS08795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O5Y_RS08800	COG1605	Chorismate mutase
O5Y_RS08810	COG0051	transcription antitermination factor activity, RNA binding
O5Y_RS08815	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
O5Y_RS08820	COG0088	Forms part of the polypeptide exit tunnel
O5Y_RS08825	COG0089	rRNA binding
O5Y_RS08830	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
O5Y_RS08835	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
O5Y_RS08840	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
O5Y_RS08845	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
O5Y_RS08850	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
O5Y_RS08855	COG0255	Belongs to the universal ribosomal protein uL29 family
O5Y_RS08860	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
O5Y_RS08865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
O5Y_RS08870	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
O5Y_RS08875	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
O5Y_RS08880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O5Y_RS08890	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
O5Y_RS08895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
O5Y_RS08900	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
O5Y_RS08905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
O5Y_RS08910	COG1841	ribosomal large subunit assembly
O5Y_RS08915	COG0200	Binds to the 23S rRNA
O5Y_RS08920	COG0201	protein transport
O5Y_RS08925	COG0563	adenylate kinase activity
O5Y_RS08935	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
O5Y_RS08945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
O5Y_RS08950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
O5Y_RS08955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
O5Y_RS08960	COG0202	RNA polymerase activity
O5Y_RS08965	COG0203	ribosomal protein L17
O5Y_RS08970	COG0101	tRNA pseudouridine synthase activity
O5Y_RS08975	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS09000	COG1404	Belongs to the peptidase S8 family
O5Y_RS09010	COG1674	ftsk spoiiie
O5Y_RS09030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
O5Y_RS09035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
O5Y_RS09040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O5Y_RS09065	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
O5Y_RS09080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
O5Y_RS09100	COG0456	acetyltransferase
O5Y_RS09105	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
O5Y_RS09125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
O5Y_RS09130	COG0459	protein refolding
O5Y_RS09180	COG0516	GMP reductase activity
O5Y_RS09200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
O5Y_RS09200	COG0519	Catalyzes the synthesis of GMP from XMP
O5Y_RS09230	COG2271	Major facilitator Superfamily
O5Y_RS09235	COG2205	protein histidine kinase activity
O5Y_RS09240	COG0745	RESPONSE REGULATOR receiver
O5Y_RS09255	COG1733	regulation of RNA biosynthetic process
O5Y_RS09270	COG0515	serine threonine protein kinase
O5Y_RS09270	COG2815	serine threonine protein kinase
O5Y_RS09300	COG3119	arylsulfatase activity
O5Y_RS09305	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O5Y_RS09345	COG2249	NAD(P)H dehydrogenase (quinone) activity
O5Y_RS09355	COG0583	DNA-binding transcription factor activity
O5Y_RS09360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O5Y_RS09365	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O5Y_RS09370	COG2271	Major facilitator Superfamily
O5Y_RS09385	COG4585	Histidine kinase
O5Y_RS09390	COG2197	response regulator
O5Y_RS09395	COG4221	oxidoreductase activity
O5Y_RS09410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS09430	COG0587	DNA-directed DNA polymerase activity
O5Y_RS09440	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS09445	COG0604	alcohol dehydrogenase
O5Y_RS09445	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS09445	COG3321	synthase
O5Y_RS09485	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O5Y_RS09495	COG0243	molybdopterin cofactor binding
O5Y_RS09500	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
O5Y_RS09525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O5Y_RS09540	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O5Y_RS09545	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
O5Y_RS09550	COG2873	o-acetylhomoserine
O5Y_RS09560	COG2814	Major facilitator Superfamily
O5Y_RS09565	COG0708	Exodeoxyribonuclease III
O5Y_RS09580	COG0180	Tryptophanyl-tRNA synthetase
O5Y_RS09585	COG1295	ribonuclease BN
O5Y_RS09590	COG1686	Belongs to the peptidase S11 family
O5Y_RS09605	COG1082	Xylose isomerase domain protein TIM barrel
O5Y_RS09610	COG0673	inositol 2-dehydrogenase activity
O5Y_RS09620	COG3962	Belongs to the TPP enzyme family
O5Y_RS09625	COG3718	enzyme involved in inositol metabolism
O5Y_RS09640	COG2188	Transcriptional regulator
O5Y_RS09650	COG2814	Major facilitator Superfamily
O5Y_RS09655	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
O5Y_RS09660	COG0242	peptide deformylase activity
O5Y_RS09675	COG0673	inositol 2-dehydrogenase activity
O5Y_RS09680	COG0673	inositol 2-dehydrogenase activity
O5Y_RS09685	COG3622	Belongs to the hyi family
O5Y_RS09690	COG0673	inositol 2-dehydrogenase activity
O5Y_RS09695	COG1609	Transcriptional regulator
O5Y_RS09705	COG1172	Belongs to the binding-protein-dependent transport system permease family
O5Y_RS09725	COG0673	inositol 2-dehydrogenase activity
O5Y_RS09730	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS09740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
O5Y_RS09745	COG1053	succinate dehydrogenase
O5Y_RS09755	COG2009	succinate dehydrogenase
O5Y_RS09790	COG0741	lytic transglycosylase activity
O5Y_RS09790	COG0791	NLP P60 protein
O5Y_RS09800	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O5Y_RS09805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O5Y_RS09825	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
O5Y_RS09825	COG1473	amidohydrolase
O5Y_RS09845	COG0436	Aminotransferase
O5Y_RS09850	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
O5Y_RS09855	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
O5Y_RS09860	COG0583	DNA-binding transcription factor activity
O5Y_RS09865	COG0477	Major facilitator Superfamily
O5Y_RS09870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O5Y_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS09935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O5Y_RS09940	COG1201	RNA secondary structure unwinding
O5Y_RS09945	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
O5Y_RS09965	COG2233	PERMEase
O5Y_RS09980	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS09990	COG1522	sequence-specific DNA binding
O5Y_RS10000	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O5Y_RS10020	COG2351	hydroxyisourate hydrolase activity
O5Y_RS10050	COG4770	biotin carboxylase activity
O5Y_RS10080	COG0477	Major facilitator Superfamily
O5Y_RS10090	COG0424	maF-like protein
O5Y_RS10100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
O5Y_RS10105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
O5Y_RS10105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
O5Y_RS10120	COG0745	RESPONSE REGULATOR receiver
O5Y_RS10125	COG2205	protein histidine kinase activity
O5Y_RS10135	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
O5Y_RS10150	COG4585	Histidine kinase
O5Y_RS10155	COG2197	response regulator
O5Y_RS10160	COG1136	(ABC) transporter
O5Y_RS10160	COG0577	efflux transmembrane transporter activity
O5Y_RS10175	COG1316	TRANSCRIPTIONal
O5Y_RS10190	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
O5Y_RS10205	COG0778	Nitroreductase
O5Y_RS10205	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
O5Y_RS10230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
O5Y_RS10240	COG1482	cell wall glycoprotein biosynthetic process
O5Y_RS10250	COG0531	amino acid
O5Y_RS10255	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5Y_RS10285	COG5002	protein histidine kinase activity
O5Y_RS10290	COG5401	PFAM Sporulation and spore germination
O5Y_RS10300	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
O5Y_RS10305	COG0653	protein targeting
O5Y_RS10345	COG1162	GTPase activity
O5Y_RS10350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
O5Y_RS10380	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O5Y_RS10395	COG1597	lipid kinase activity
O5Y_RS10410	COG0406	alpha-ribazole phosphatase activity
O5Y_RS10415	COG1192	Involved in chromosome partitioning
O5Y_RS10425	COG0513	Belongs to the DEAD box helicase family
O5Y_RS10460	COG2186	Transcriptional regulator
O5Y_RS10475	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O5Y_RS10475	COG2146	nitrite reductase [NAD(P)H] activity
O5Y_RS10480	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
O5Y_RS10480	COG2146	nitrite reductase [NAD(P)H] activity
O5Y_RS10515	COG0746	molybdenum cofactor guanylyltransferase activity
O5Y_RS10525	COG0596	Alpha beta hydrolase
O5Y_RS10530	COG0210	DNA helicase
O5Y_RS10570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
O5Y_RS10585	COG3480	Lon protease (S16) C-terminal proteolytic domain
O5Y_RS10595	COG1615	UPF0182 protein
O5Y_RS10600	COG1388	LysM domain
O5Y_RS10625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS10645	COG0402	S-adenosylhomocysteine deaminase activity
O5Y_RS10650	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS10655	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS10665	COG3851	Histidine kinase
O5Y_RS10670	COG2197	response regulator
O5Y_RS10675	COG2132	Multicopper oxidase
O5Y_RS10680	COG0483	inositol monophosphate 1-phosphatase activity
O5Y_RS10690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
O5Y_RS10695	COG0668	transmembrane transport
O5Y_RS10705	COG2884	Cell division ATP-binding protein ftsE
O5Y_RS10710	COG2177	Part of the ABC transporter FtsEX involved in
O5Y_RS10715	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
O5Y_RS10735	COG0702	epimerase
O5Y_RS10740	COG3119	arylsulfatase activity
O5Y_RS10770	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5Y_RS10775	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5Y_RS10785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O5Y_RS10790	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
O5Y_RS10825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O5Y_RS10840	COG0778	Nitroreductase
O5Y_RS10845	COG0513	Belongs to the DEAD box helicase family
O5Y_RS10855	COG0521	Mo-molybdopterin cofactor biosynthetic process
O5Y_RS10855	COG0315	cyclic pyranopterin monophosphate synthase activity
O5Y_RS10865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
O5Y_RS10880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
O5Y_RS10895	COG1309	transcriptional regulator
O5Y_RS10915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
O5Y_RS10945	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS10950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O5Y_RS10975	COG1119	ATPase activity
O5Y_RS10990	COG2226	methyltransferase
O5Y_RS11005	COG0110	maltose O-acetyltransferase activity
O5Y_RS11025	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O5Y_RS11035	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
O5Y_RS11055	COG0482	sulfurtransferase activity
O5Y_RS11065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
O5Y_RS11080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O5Y_RS11085	COG0154	amidase activity
O5Y_RS11100	COG4585	Histidine kinase
O5Y_RS11105	COG2197	response regulator
O5Y_RS11110	COG0205	6-phosphofructokinase activity
O5Y_RS11115	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
O5Y_RS11130	COG2259	Doxx family
O5Y_RS11135	COG0531	amino acid
O5Y_RS11140	COG0129	dihydroxy-acid dehydratase activity
O5Y_RS11155	COG0440	acetolactate synthase activity
O5Y_RS11160	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
O5Y_RS11170	COG0473	3-isopropylmalate dehydrogenase activity
O5Y_RS11175	COG0179	Fumarylacetoacetate (FAA) hydrolase
O5Y_RS11180	COG3239	Fatty acid desaturase
O5Y_RS11185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
O5Y_RS11210	COG1414	Transcriptional regulator
O5Y_RS11215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
O5Y_RS11220	COG0066	3-isopropylmalate dehydratase activity
O5Y_RS11235	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
O5Y_RS11240	COG1920	GTP binding
O5Y_RS11245	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O5Y_RS11250	COG0626	cystathionine gamma-synthase activity
O5Y_RS11255	COG1181	Belongs to the D-alanine--D-alanine ligase family
O5Y_RS11275	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
O5Y_RS11285	COG1461	Dihydroxyacetone kinase
O5Y_RS11290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
O5Y_RS11295	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O5Y_RS11300	COG0742	ribosomal rna small subunit methyltransferase
O5Y_RS11305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
O5Y_RS11320	COG0571	ribonuclease III activity
O5Y_RS11325	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O5Y_RS11340	COG1254	Belongs to the acylphosphatase family
O5Y_RS11345	COG1196	nuclear chromosome segregation
O5Y_RS11365	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
O5Y_RS11380	COG0228	four-way junction DNA binding
O5Y_RS11390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
O5Y_RS11395	COG0336	Belongs to the RNA methyltransferase TrmD family
O5Y_RS11420	COG0463	Glycosyl transferase, family 2
O5Y_RS11425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
O5Y_RS11445	COG0335	large ribosomal subunit rRNA binding
O5Y_RS11455	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
O5Y_RS11465	COG1690	Belongs to the RtcB family
O5Y_RS11490	COG0792	nuclease activity
O5Y_RS11515	COG2814	Major facilitator Superfamily
O5Y_RS11535	COG0052	Belongs to the universal ribosomal protein uS2 family
O5Y_RS11540	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
O5Y_RS11545	COG0528	UMP kinase activity
O5Y_RS11550	COG0233	cytoplasmic translational termination
O5Y_RS11555	COG0575	Belongs to the CDS family
O5Y_RS11560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
O5Y_RS11575	COG0820	rRNA (adenine-C2-)-methyltransferase activity
O5Y_RS11585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
O5Y_RS11590	COG0750	zinc metalloprotease
O5Y_RS11610	COG2197	response regulator
O5Y_RS11615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O5Y_RS11650	COG2188	Transcriptional regulator
O5Y_RS11655	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS11680	COG1760	l-serine dehydratase
O5Y_RS11710	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O5Y_RS11750	COG2207	Transcriptional regulator
O5Y_RS11755	COG2076	Multidrug Resistance protein
O5Y_RS11775	COG1492	cobalamin metabolic process
O5Y_RS11795	COG0384	phenazine biosynthesis protein PhzF
O5Y_RS11800	COG3467	pyridoxamine 5'-phosphate
O5Y_RS11810	COG1024	Enoyl-CoA hydratase
O5Y_RS11845	COG0579	oxidoreductase
O5Y_RS11875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
O5Y_RS11875	COG1648	precorrin-2 dehydrogenase activity
O5Y_RS11885	COG0517	IMP dehydrogenase activity
O5Y_RS11890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
O5Y_RS11895	COG3022	response to hydroperoxide
O5Y_RS11900	COG0442	prolyl-tRNA aminoacylation
O5Y_RS11905	COG4122	O-methyltransferase activity
O5Y_RS11935	COG0697	spore germination
O5Y_RS11940	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS11955	COG0477	Major facilitator Superfamily
O5Y_RS11970	COG0779	Required for maturation of 30S ribosomal subunits
O5Y_RS11980	COG0481	GTPase activity
O5Y_RS11980	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
O5Y_RS11990	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
O5Y_RS11995	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
O5Y_RS12005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O5Y_RS12015	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
O5Y_RS12035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
O5Y_RS12040	COG1185	polyribonucleotide nucleotidyltransferase activity
O5Y_RS12060	COG0375	protein maturation
O5Y_RS12080	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
O5Y_RS12115	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
O5Y_RS12120	COG0298	carbon dioxide binding
O5Y_RS12125	COG0409	Hydrogenase expression formation protein
O5Y_RS12130	COG0309	Hydrogenase expression formation protein (HypE)
O5Y_RS12150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O5Y_RS12170	COG0657	acetylesterase activity
O5Y_RS12175	COG2365	Tyrosine phosphatase family
O5Y_RS12200	COG0789	Transcriptional regulator
O5Y_RS12205	COG0095	Lipoate-protein ligase
O5Y_RS12235	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
O5Y_RS12265	COG1535	isochorismatase
O5Y_RS12265	COG3433	isochorismatase activity
O5Y_RS12270	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS12275	COG1021	2,3-dihydroxybenzoate-AMP ligase
O5Y_RS12280	COG3433	isochorismatase activity
O5Y_RS12280	COG1535	isochorismatase
O5Y_RS12290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O5Y_RS12295	COG4592	Periplasmic binding protein
O5Y_RS12305	COG2375	cellular response to nickel ion
O5Y_RS12320	COG1131	(ABC) transporter
O5Y_RS12365	COG0713	ATP synthesis coupled electron transport
O5Y_RS12375	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O5Y_RS12380	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
O5Y_RS12385	COG1034	ATP synthesis coupled electron transport
O5Y_RS12400	COG0649	NAD binding
O5Y_RS12410	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
O5Y_RS12445	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
O5Y_RS12470	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
O5Y_RS12480	COG1546	Belongs to the CinA family
O5Y_RS12480	COG1058	Belongs to the CinA family
O5Y_RS12485	COG1396	sequence-specific DNA binding
O5Y_RS12490	COG1842	Phage shock protein A
O5Y_RS12500	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
O5Y_RS12505	COG1122	ATPase activity
O5Y_RS12510	COG1268	BioY protein
O5Y_RS12545	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
O5Y_RS12550	COG2137	regulation of response to DNA damage stimulus
O5Y_RS12555	COG0765	amino acid transport
O5Y_RS12560	COG0765	amino acid transport
O5Y_RS12565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O5Y_RS12570	COG1126	abc transporter atp-binding protein
O5Y_RS12575	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
O5Y_RS12585	COG1196	nuclear chromosome segregation
O5Y_RS12595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
O5Y_RS12605	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
O5Y_RS12610	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
O5Y_RS12620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS12625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
O5Y_RS12630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O5Y_RS12630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
O5Y_RS12630	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
O5Y_RS12635	COG1105	Belongs to the carbohydrate kinase PfkB family
O5Y_RS12640	COG1349	DNA-binding transcription factor activity
O5Y_RS12645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O5Y_RS12650	COG2233	PERMEase
O5Y_RS12655	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS12665	COG1388	LysM domain
O5Y_RS12670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
O5Y_RS12675	COG1643	Atp-dependent helicase
O5Y_RS12710	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O5Y_RS12715	COG0450	alkyl hydroperoxide reductase
O5Y_RS12725	COG0277	FAD linked oxidase domain protein
O5Y_RS12790	COG0123	including yeast histone deacetylase and acetoin utilization protein
O5Y_RS12795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
O5Y_RS12795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O5Y_RS12805	COG2813	Specifically methylates the guanine in position
O5Y_RS12845	COG0475	glutathione-regulated potassium exporter activity
O5Y_RS12850	COG2365	Tyrosine phosphatase family
O5Y_RS12865	COG0483	inositol monophosphate 1-phosphatase activity
O5Y_RS12885	COG0756	dUTP diphosphatase activity
O5Y_RS12920	COG0569	domain protein
O5Y_RS12925	COG0531	amino acid
O5Y_RS12940	COG0477	Major facilitator Superfamily
O5Y_RS12950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
O5Y_RS12950	COG2066	Belongs to the glutaminase family
O5Y_RS12955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
O5Y_RS12960	COG0477	Major facilitator Superfamily
O5Y_RS12985	COG1250	3-hydroxyacyl-CoA dehydrogenase
O5Y_RS12985	COG1024	Enoyl-CoA hydratase
O5Y_RS12990	COG0183	Belongs to the thiolase family
O5Y_RS13010	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
O5Y_RS13045	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
O5Y_RS13065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O5Y_RS13075	COG2223	nitrite transmembrane transporter activity
O5Y_RS13080	COG2723	6-phospho-beta-galactosidase activity
O5Y_RS13125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
O5Y_RS13140	COG1560	Kdo2-lipid A biosynthetic process
O5Y_RS13145	COG0438	transferase activity, transferring glycosyl groups
O5Y_RS13150	COG1051	belongs to the nudix hydrolase family
O5Y_RS13155	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
O5Y_RS13175	COG1946	Acyl-CoA thioesterase
O5Y_RS13185	COG1946	Acyl-CoA thioesterase
O5Y_RS13195	COG2197	response regulator
O5Y_RS13200	COG4585	Histidine kinase
O5Y_RS13220	COG2188	Transcriptional regulator
O5Y_RS13225	COG0217	transcriptional regulatory protein
O5Y_RS13230	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
O5Y_RS13235	COG0632	four-way junction helicase activity
O5Y_RS13240	COG2255	four-way junction helicase activity
O5Y_RS13255	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
O5Y_RS13260	COG0747	negative chemotaxis
O5Y_RS13265	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
O5Y_RS13270	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
O5Y_RS13275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O5Y_RS13280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
O5Y_RS13290	COG0124	histidyl-tRNA synthetase
O5Y_RS13300	COG0039	L-malate dehydrogenase activity
O5Y_RS13330	COG1131	(ABC) transporter
O5Y_RS13350	COG1053	succinate dehydrogenase
O5Y_RS13395	COG2184	nucleotidyltransferase activity
O5Y_RS13425	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
O5Y_RS13455	COG0662	Cupin 2, conserved barrel domain protein
O5Y_RS13475	COG1309	transcriptional regulator
O5Y_RS13480	COG2824	Alkylphosphonate utilization operon protein PhnA
O5Y_RS13515	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
O5Y_RS13540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
O5Y_RS13545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
O5Y_RS13555	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O5Y_RS13570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
O5Y_RS13575	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
O5Y_RS13580	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O5Y_RS13600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
O5Y_RS13605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
O5Y_RS13610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
O5Y_RS13615	COG0540	Belongs to the ATCase OTCase family
O5Y_RS13630	COG0505	Belongs to the CarA family
O5Y_RS13640	COG0284	orotidine-5'-phosphate decarboxylase activity
O5Y_RS13645	COG1051	belongs to the nudix hydrolase family
O5Y_RS13655	COG0194	GDP metabolic process
O5Y_RS13660	COG1758	RNA polymerase activity
O5Y_RS13670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
O5Y_RS13695	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O5Y_RS13725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O5Y_RS13725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
O5Y_RS13740	COG0322	excinuclease ABC activity
O5Y_RS13745	COG1660	Displays ATPase and GTPase activities
O5Y_RS13760	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
O5Y_RS13765	COG0126	phosphoglycerate kinase activity
O5Y_RS13770	COG0149	triose-phosphate isomerase activity
O5Y_RS13775	COG2365	Tyrosine phosphatase family
O5Y_RS13785	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
O5Y_RS13790	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS13805	COG1129	ABC transporter
O5Y_RS13815	COG4221	oxidoreductase activity
O5Y_RS13835	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
O5Y_RS13845	COG0109	protoheme IX farnesyltransferase activity
O5Y_RS13900	COG0396	ATPase activity
O5Y_RS13910	COG0822	iron-sulfur transferase activity
O5Y_RS13925	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
O5Y_RS13940	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS13945	COG0488	(ABC) transporter
O5Y_RS13950	COG1309	transcriptional regulator
O5Y_RS13955	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
O5Y_RS13965	COG3883	PFAM NLP P60 protein
O5Y_RS13965	COG0791	NLP P60 protein
O5Y_RS13970	COG0714	Associated with various cellular activities
O5Y_RS13980	COG2304	oxidoreductase activity
O5Y_RS13995	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
O5Y_RS14015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
O5Y_RS14015	COG1024	Enoyl-CoA hydratase
O5Y_RS14070	COG0730	response to heat
O5Y_RS14095	COG1253	flavin adenine dinucleotide binding
O5Y_RS14100	COG1253	flavin adenine dinucleotide binding
O5Y_RS14110	COG0697	spore germination
O5Y_RS14115	COG0513	Belongs to the DEAD box helicase family
O5Y_RS14120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
O5Y_RS14125	COG0513	Belongs to the DEAD box helicase family
O5Y_RS14140	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O5Y_RS14145	COG1120	ATPase activity
O5Y_RS14150	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS14155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS14170	COG1252	NADH dehydrogenase
O5Y_RS14175	COG0640	Transcriptional regulator
O5Y_RS14215	COG3300	MHYT domain
O5Y_RS14215	COG5001	Diguanylate cyclase
O5Y_RS14280	COG2197	response regulator
O5Y_RS14285	COG4585	Histidine kinase
O5Y_RS14305	COG1090	epimerase
O5Y_RS14380	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
O5Y_RS14385	COG4762	Protein conserved in bacteria
O5Y_RS14400	COG2205	protein histidine kinase activity
O5Y_RS14415	COG2241	protein methyltransferase activity
O5Y_RS14415	COG2242	protein methyltransferase activity
O5Y_RS14420	COG0300	oxidoreductase activity
O5Y_RS14455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
O5Y_RS14460	COG2378	regulation of single-species biofilm formation
O5Y_RS14470	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O5Y_RS14485	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
O5Y_RS14510	COG1222	aaa ATPase
O5Y_RS14525	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
O5Y_RS14535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
O5Y_RS14540	COG0140	phosphoribosyl-ATP diphosphatase activity
O5Y_RS14550	COG1054	Belongs to the UPF0176 family
O5Y_RS14560	COG0646	methionine synthase
O5Y_RS14560	COG1410	methionine synthase
O5Y_RS14595	COG0215	cysteine-tRNA ligase activity
O5Y_RS14600	COG2409	Drug exporters of the RND superfamily
O5Y_RS14625	COG1968	undecaprenyl-diphosphatase activity
O5Y_RS14630	COG0667	Aldo Keto reductase
O5Y_RS14645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS14650	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O5Y_RS14670	COG0167	dihydroorotate dehydrogenase activity
O5Y_RS14680	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O5Y_RS14705	COG3268	Saccharopine dehydrogenase
O5Y_RS14710	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
O5Y_RS14720	COG1408	metallophosphoesterase
O5Y_RS14745	COG1716	ATPase activity
O5Y_RS14780	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
O5Y_RS14790	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS14800	COG0351	phosphomethylpyrimidine kinase
O5Y_RS14830	COG0444	Belongs to the ABC transporter superfamily
O5Y_RS14835	COG4608	Belongs to the ABC transporter superfamily
O5Y_RS14840	COG0747	negative chemotaxis
O5Y_RS14850	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS14890	COG1160	GTP binding
O5Y_RS14895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
O5Y_RS14905	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
O5Y_RS14910	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
O5Y_RS14925	COG0494	nUDIX hydrolase
O5Y_RS14930	COG0504	CTP synthase activity
O5Y_RS14950	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
O5Y_RS14965	COG0647	UMP catabolic process
O5Y_RS14995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
O5Y_RS15000	COG2094	Belongs to the DNA glycosylase MPG family
O5Y_RS15005	COG1131	(ABC) transporter
O5Y_RS15020	COG2835	tetraacyldisaccharide 4'-kinase activity
O5Y_RS15030	COG0165	Argininosuccinate lyase
O5Y_RS15035	COG0137	argininosuccinate synthase activity
O5Y_RS15040	COG1438	arginine binding
O5Y_RS15045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
O5Y_RS15050	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
O5Y_RS15055	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
O5Y_RS15060	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
O5Y_RS15065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
O5Y_RS15075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
O5Y_RS15080	COG0385	Bile acid
O5Y_RS15085	COG2072	flavoprotein involved in K transport
O5Y_RS15095	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
O5Y_RS15095	COG0072	phenylalanine-tRNA ligase activity
O5Y_RS15100	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
O5Y_RS15110	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
O5Y_RS15115	COG0291	Belongs to the bacterial ribosomal protein bL35 family
O5Y_RS15150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS15195	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
O5Y_RS15195	COG0237	dephospho-CoA kinase activity
O5Y_RS15200	COG0539	negative regulation of cytoplasmic translation
O5Y_RS15205	COG2226	methyltransferase
O5Y_RS15205	COG1073	alpha beta
O5Y_RS15220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
O5Y_RS15225	COG0473	3-isopropylmalate dehydrogenase activity
O5Y_RS15250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
O5Y_RS15260	COG1172	Belongs to the binding-protein-dependent transport system permease family
O5Y_RS15300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
O5Y_RS15310	COG1946	Acyl-CoA thioesterase
O5Y_RS15325	COG0069	glutamate synthase activity
O5Y_RS15325	COG0067	glutamate synthase
O5Y_RS15325	COG0070	glutamate synthase
O5Y_RS15340	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
O5Y_RS15345	COG0159	tryptophan synthase activity
O5Y_RS15355	COG0134	indole-3-glycerol-phosphate synthase activity
O5Y_RS15365	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
O5Y_RS15375	COG3384	dioxygenase
O5Y_RS15385	COG1053	succinate dehydrogenase
O5Y_RS15410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
O5Y_RS15435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS15440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
O5Y_RS15445	COG2124	cytochrome p450
O5Y_RS15490	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS15515	COG1053	succinate dehydrogenase
O5Y_RS15540	COG2080	2 iron, 2 sulfur cluster binding
O5Y_RS15540	COG1529	Aldehyde oxidase and xanthine dehydrogenase
O5Y_RS15555	COG2132	Multicopper oxidase
O5Y_RS15575	COG0640	Transcriptional regulator
O5Y_RS15600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
O5Y_RS15610	COG2072	flavoprotein involved in K transport
O5Y_RS15620	COG0107	imidazoleglycerol-phosphate synthase activity
O5Y_RS15625	COG0483	inositol monophosphate 1-phosphatase activity
O5Y_RS15630	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
O5Y_RS15640	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
O5Y_RS15655	COG0131	Imidazoleglycerol-phosphate dehydratase
O5Y_RS15665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
O5Y_RS15700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
O5Y_RS15710	COG1280	lysine exporter protein (LysE YggA)
O5Y_RS15725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
O5Y_RS15750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O5Y_RS15750	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
O5Y_RS15760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS15765	COG1510	regulation of RNA biosynthetic process
O5Y_RS15780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
O5Y_RS15795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O5Y_RS15835	COG4221	oxidoreductase activity
O5Y_RS15850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
O5Y_RS15920	COG2199	diguanylate cyclase activity
O5Y_RS15925	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
O5Y_RS15935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
O5Y_RS15950	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS15955	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS15955	COG3321	synthase
O5Y_RS15955	COG0604	alcohol dehydrogenase
O5Y_RS15965	COG1309	transcriptional regulator
O5Y_RS15970	COG5006	permease, DMT superfamily
O5Y_RS15995	COG0477	Major facilitator Superfamily
O5Y_RS16005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
O5Y_RS16010	COG0798	PFAM Bile acid sodium symporter
O5Y_RS16015	COG0640	Transcriptional regulator
O5Y_RS16035	COG0477	Major facilitator Superfamily
O5Y_RS16050	COG0028	Belongs to the TPP enzyme family
O5Y_RS16085	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
O5Y_RS16100	COG0076	glutamate decarboxylase activity
O5Y_RS16120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
O5Y_RS16130	COG3599	regulation of cell shape
O5Y_RS16145	COG1799	cell septum assembly
O5Y_RS16155	COG1496	oxidoreductase activity
O5Y_RS16160	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
O5Y_RS16165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
O5Y_RS16170	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
O5Y_RS16175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
O5Y_RS16185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
O5Y_RS16205	COG0768	penicillin binding
O5Y_RS16215	COG0275	rRNA processing
O5Y_RS16220	COG2001	Belongs to the MraZ family
O5Y_RS16255	COG0142	geranyltranstransferase activity
O5Y_RS16295	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
O5Y_RS16310	COG1940	carbohydrate kinase activity
O5Y_RS16320	COG0003	Pfam Anion-transporting ATPase
O5Y_RS16330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O5Y_RS16355	COG0791	NLP P60 protein
O5Y_RS16370	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
O5Y_RS16380	COG1845	cytochrome c oxidase, subunit III
O5Y_RS16415	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
O5Y_RS16425	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5Y_RS16445	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
O5Y_RS16450	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
O5Y_RS16455	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
O5Y_RS16470	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
O5Y_RS16475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
O5Y_RS16480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
O5Y_RS16500	COG0321	lipoyl(octanoyl) transferase activity
O5Y_RS16505	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
O5Y_RS16520	COG0174	glutamine synthetase
O5Y_RS16535	COG2267	carboxylic ester hydrolase activity
O5Y_RS16605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
O5Y_RS16645	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
O5Y_RS16660	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
O5Y_RS16690	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
O5Y_RS16705	COG3323	Protein of unknown function (DUF1653)
O5Y_RS16705	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
O5Y_RS16730	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
O5Y_RS16770	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
O5Y_RS16780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
O5Y_RS16785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O5Y_RS16790	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
O5Y_RS16825	COG4585	Histidine kinase
O5Y_RS16830	COG2409	Drug exporters of the RND superfamily
O5Y_RS16835	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5Y_RS16840	COG3842	ATPase activity
O5Y_RS16845	COG0395	ABC-type sugar transport system, permease component
O5Y_RS16865	COG1063	alcohol dehydrogenase
O5Y_RS16940	COG0232	Belongs to the dGTPase family. Type 2 subfamily
O5Y_RS16955	COG0463	Glycosyl transferase, family 2
O5Y_RS16980	COG0423	glycine-tRNA ligase activity
O5Y_RS17000	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O5Y_RS17005	COG1381	Involved in DNA repair and RecF pathway recombination
O5Y_RS17030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS17035	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
O5Y_RS17045	COG1063	alcohol dehydrogenase
O5Y_RS17060	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
O5Y_RS17065	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
O5Y_RS17070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
O5Y_RS17100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
O5Y_RS17115	COG0477	Major facilitator Superfamily
O5Y_RS17125	COG1376	ErfK ybiS ycfS ynhG family protein
O5Y_RS17135	COG0484	heat shock protein binding
O5Y_RS17140	COG1420	regulation of RNA biosynthetic process
O5Y_RS17170	COG0175	sulfate reduction
O5Y_RS17200	COG3842	ATPase activity
O5Y_RS17205	COG4208	sulfate ABC transporter
O5Y_RS17225	COG3387	PFAM Glycoside hydrolase 15-related
O5Y_RS17230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS17235	COG2070	2-Nitropropane dioxygenase
O5Y_RS17240	COG0481	GTPase activity
O5Y_RS17250	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
O5Y_RS17255	COG1305	Transglutaminase-like
O5Y_RS17270	COG0268	Binds directly to 16S ribosomal RNA
O5Y_RS17285	COG0658	competence protein
O5Y_RS17285	COG2333	competence protein COMEC
O5Y_RS17300	COG2755	lipolytic protein G-D-S-L family
O5Y_RS17305	COG0406	alpha-ribazole phosphatase activity
O5Y_RS17315	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
O5Y_RS17325	COG0542	response to heat
O5Y_RS17330	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
O5Y_RS17335	COG1902	pentaerythritol trinitrate reductase activity
O5Y_RS17345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
O5Y_RS17355	COG0514	ATP-dependent DNA helicase (RecQ)
O5Y_RS17360	COG0456	acetyltransferase
O5Y_RS17365	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O5Y_RS17370	COG1917	Cupin 2, conserved barrel domain protein
O5Y_RS17375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
O5Y_RS17395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
O5Y_RS17400	COG0211	Belongs to the bacterial ribosomal protein bL27 family
O5Y_RS17405	COG0261	This protein binds to 23S rRNA in the presence of protein L20
O5Y_RS17410	COG1530	ribonuclease E activity
O5Y_RS17410	COG1530	ribonuclease E activity
O5Y_RS17415	COG0105	UTP biosynthetic process
O5Y_RS17425	COG0285	dihydrofolate synthase activity
O5Y_RS17430	COG0525	valine-tRNA ligase activity
O5Y_RS17440	COG4946	Tricorn protease homolog
O5Y_RS17440	COG1506	peptidase
O5Y_RS17440	COG0823	Involved in the tonB-independent uptake of proteins
O5Y_RS17460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
O5Y_RS17465	COG1082	Xylose isomerase domain protein TIM barrel
O5Y_RS17465	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O5Y_RS17470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O5Y_RS17475	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
O5Y_RS17480	COG1309	transcriptional regulator
O5Y_RS17490	COG0477	Major facilitator Superfamily
O5Y_RS17495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
O5Y_RS17500	COG0740	serine-type endopeptidase activity
O5Y_RS17505	COG0740	serine-type endopeptidase activity
O5Y_RS17510	COG0544	peptidyl-prolyl cis-trans isomerase activity
O5Y_RS17545	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
O5Y_RS17560	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
O5Y_RS17600	COG2902	Dehydrogenase
O5Y_RS17620	COG1132	(ABC) transporter
O5Y_RS17625	COG1846	Transcriptional regulator
O5Y_RS17635	COG3336	cytochrome c oxidase
O5Y_RS17650	COG3764	Sortase (surface protein transpeptidase)
O5Y_RS17675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O5Y_RS17705	COG0596	Alpha beta hydrolase
O5Y_RS17725	COG0446	pyridine nucleotide-disulphide oxidoreductase
O5Y_RS17725	COG1902	pentaerythritol trinitrate reductase activity
O5Y_RS17730	COG0300	oxidoreductase activity
O5Y_RS17745	COG0433	COG0433 Predicted ATPase
O5Y_RS17750	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
O5Y_RS17760	COG0789	Transcriptional regulator
O5Y_RS17770	COG1376	ErfK ybiS ycfS ynhG family protein
O5Y_RS17810	COG0736	holo-[acyl-carrier-protein] synthase activity
O5Y_RS17845	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
O5Y_RS17850	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
O5Y_RS17855	COG1234	tRNA 3'-trailer cleavage
O5Y_RS17865	COG3191	aminopeptidase activity
O5Y_RS17875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
O5Y_RS17880	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
O5Y_RS17885	COG1335	isochorismatase
O5Y_RS17895	COG0058	SHG alpha-glucan phosphorylase activity
O5Y_RS17900	COG0366	Alpha amylase catalytic
O5Y_RS17905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
O5Y_RS17925	COG0183	Belongs to the thiolase family
O5Y_RS17930	COG0346	lactoylglutathione lyase activity
O5Y_RS17940	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
O5Y_RS17970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
O5Y_RS17985	COG0355	proton-transporting ATP synthase activity, rotational mechanism
O5Y_RS17990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
O5Y_RS17995	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
O5Y_RS18000	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
O5Y_RS18005	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O5Y_RS18010	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
O5Y_RS18015	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
O5Y_RS18020	COG0356	it plays a direct role in the translocation of protons across the membrane
O5Y_RS18030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O5Y_RS18035	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O5Y_RS18045	COG2890	protein-(glutamine-N5) methyltransferase activity
O5Y_RS18050	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
O5Y_RS18055	COG0254	rRNA binding
O5Y_RS18065	COG0083	homoserine kinase activity
O5Y_RS18070	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
O5Y_RS18075	COG0460	homoserine dehydrogenase
O5Y_RS18080	COG0019	diaminopimelate decarboxylase activity
O5Y_RS18085	COG0018	arginyl-trna synthetase
O5Y_RS18100	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
O5Y_RS18110	COG0583	DNA-binding transcription factor activity
O5Y_RS18115	COG0477	Major facilitator Superfamily
O5Y_RS18135	COG0686	Belongs to the AlaDH PNT family
O5Y_RS18145	COG1218	3'(2'),5'-bisphosphate nucleotidase
O5Y_RS18180	COG0596	Alpha beta hydrolase
O5Y_RS18210	COG2814	Major facilitator Superfamily
O5Y_RS18215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
O5Y_RS18235	COG1024	Enoyl-CoA hydratase
O5Y_RS18240	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS18250	COG3142	Participates in the control of copper homeostasis
O5Y_RS18255	COG0363	glucosamine-6-phosphate deaminase activity
O5Y_RS18260	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
O5Y_RS18265	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
O5Y_RS18275	COG1263	PTS System
O5Y_RS18280	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
O5Y_RS18285	COG2190	(PTS) system
O5Y_RS18290	COG2188	Transcriptional regulator
O5Y_RS18295	COG4279	zinc finger
O5Y_RS18300	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O5Y_RS18305	COG3321	synthase
O5Y_RS18305	COG0604	alcohol dehydrogenase
O5Y_RS18320	COG4974	Belongs to the 'phage' integrase family
O5Y_RS18350	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O5Y_RS18365	COG1280	lysine exporter protein (LysE YggA)
O5Y_RS18375	COG3135	benzoate transporter
O5Y_RS18395	COG0022	dehydrogenase e1 component
O5Y_RS18400	COG0508	dehydrogenase complex catalyzes the overall conversion of
O5Y_RS18405	COG2223	nitrite transmembrane transporter activity
O5Y_RS18430	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS18465	COG0352	thiamine-phosphate diphosphorylase activity
O5Y_RS18465	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
O5Y_RS18465	COG0351	phosphomethylpyrimidine kinase
O5Y_RS18470	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O5Y_RS18475	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS18505	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
O5Y_RS18510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
O5Y_RS18515	COG1522	sequence-specific DNA binding
O5Y_RS18560	COG1063	alcohol dehydrogenase
O5Y_RS18570	COG3976	FMN-binding domain protein
O5Y_RS18570	COG1053	succinate dehydrogenase
O5Y_RS18585	COG1022	Amp-dependent synthetase and ligase
O5Y_RS18600	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O5Y_RS18630	COG0513	Belongs to the DEAD box helicase family
O5Y_RS18640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O5Y_RS18655	COG1201	RNA secondary structure unwinding
O5Y_RS18660	COG0210	DNA helicase
O5Y_RS18690	COG2801	Transposase and inactivated derivatives
O5Y_RS18735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
O5Y_RS18745	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS18750	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS18760	COG0531	amino acid
O5Y_RS18765	COG3457	Alanine racemase
O5Y_RS18780	COG4172	Belongs to the ABC transporter superfamily
O5Y_RS18785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS18815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS18820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS18825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
O5Y_RS18830	COG1823	symporter activity
O5Y_RS18845	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
O5Y_RS18895	COG0439	Biotin carboxylase
O5Y_RS18915	COG0667	Aldo Keto reductase
O5Y_RS18940	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS18950	COG0577	efflux transmembrane transporter activity
O5Y_RS18955	COG1136	(ABC) transporter
O5Y_RS18955	COG0577	efflux transmembrane transporter activity
O5Y_RS18960	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS18965	COG3012	SEC-C Motif Domain Protein
O5Y_RS18975	COG1132	(ABC) transporter
O5Y_RS18985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5Y_RS19000	COG1022	Amp-dependent synthetase and ligase
O5Y_RS19010	COG0277	FAD linked oxidase domain protein
O5Y_RS19020	COG1335	isochorismatase
O5Y_RS19025	COG2267	carboxylic ester hydrolase activity
O5Y_RS19050	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
O5Y_RS19055	COG1024	Enoyl-CoA hydratase
O5Y_RS19060	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS19070	COG0277	FAD linked oxidase domain protein
O5Y_RS19090	COG0435	Glutathione S-transferase
O5Y_RS19105	COG1131	(ABC) transporter
O5Y_RS19115	COG1132	(ABC) transporter
O5Y_RS19120	COG0508	dehydrogenase complex catalyzes the overall conversion of
O5Y_RS19120	COG0567	Dehydrogenase, E1 component
O5Y_RS19125	COG1309	transcriptional regulator
O5Y_RS19155	COG1125	glycine betaine transport
O5Y_RS19155	COG0517	IMP dehydrogenase activity
O5Y_RS19160	COG1174	glycine betaine transport
O5Y_RS19180	COG2095	MarC family integral membrane protein
O5Y_RS19190	COG0598	Magnesium transport protein CorA
O5Y_RS19255	COG2301	Belongs to the HpcH HpaI aldolase family
O5Y_RS19260	COG2239	Acts as a magnesium transporter
O5Y_RS19290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O5Y_RS19295	COG5662	AntiSigma factor
O5Y_RS19310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
O5Y_RS19315	COG0297	glycogen (starch) synthase activity
O5Y_RS19320	COG2226	methyltransferase
O5Y_RS19325	COG0519	Catalyzes the synthesis of GMP from XMP
O5Y_RS19335	COG0463	Glycosyl transferase, family 2
O5Y_RS19340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
O5Y_RS19345	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS19350	COG1611	Belongs to the LOG family
O5Y_RS19355	COG1611	Belongs to the LOG family
O5Y_RS19365	COG2171	N-acyltransferase activity
O5Y_RS19370	COG1113	amino acid transport
O5Y_RS19380	COG1131	(ABC) transporter
O5Y_RS19395	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS19400	COG0457	Tetratricopeptide repeat
O5Y_RS19400	COG0705	Rhomboid family
O5Y_RS19420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
O5Y_RS19450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O5Y_RS19455	COG0747	negative chemotaxis
O5Y_RS19470	COG2154	pterin-4-alpha-carbinolamine dehydratase
O5Y_RS19490	COG2814	Major facilitator Superfamily
O5Y_RS19500	COG3757	hydrolase, family 25
O5Y_RS19515	COG0402	S-adenosylhomocysteine deaminase activity
O5Y_RS19550	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
O5Y_RS19550	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
O5Y_RS19595	COG0584	glycerophosphoryl diester phosphodiesterase
O5Y_RS19610	COG0012	GTP binding
O5Y_RS19620	COG0069	glutamate synthase activity
O5Y_RS19625	COG1966	Carbon starvation protein
O5Y_RS19645	COG0419	ATPase involved in DNA repair
O5Y_RS19650	COG0420	3'-5' exonuclease activity
O5Y_RS19660	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
O5Y_RS19670	COG1570	exodeoxyribonuclease VII activity
O5Y_RS19710	COG0477	Major facilitator Superfamily
O5Y_RS19720	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
O5Y_RS19730	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
O5Y_RS19735	COG2197	response regulator
O5Y_RS19745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
O5Y_RS19755	COG1072	(Pantothenic acid kinase))
O5Y_RS19760	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
O5Y_RS19770	COG1331	Highly conserved protein containing a thioredoxin domain
O5Y_RS19780	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
O5Y_RS19790	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
O5Y_RS19795	COG0791	NLP P60 protein
O5Y_RS19795	COG3883	PFAM NLP P60 protein
O5Y_RS19810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
O5Y_RS19825	COG2755	lipolytic protein G-D-S-L family
O5Y_RS19830	COG0183	Belongs to the thiolase family
O5Y_RS19835	COG1024	Enoyl-CoA hydratase
O5Y_RS19845	COG2813	Specifically methylates the guanine in position
O5Y_RS19860	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS19865	COG5001	Diguanylate cyclase
O5Y_RS19870	COG5001	Diguanylate cyclase
O5Y_RS19910	COG0148	phosphopyruvate hydratase activity
O5Y_RS19920	COG0672	)-iron permease
O5Y_RS19930	COG2837	iron assimilation
O5Y_RS19995	COG3956	TIGRFAM MazG family protein
O5Y_RS20015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
O5Y_RS20025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
O5Y_RS20030	COG0736	holo-[acyl-carrier-protein] synthase activity
O5Y_RS20040	COG1309	transcriptional regulator
O5Y_RS20065	COG0471	metal ion transport
O5Y_RS20065	COG0490	domain, Protein
O5Y_RS20075	COG2133	pyrroloquinoline quinone binding
O5Y_RS20080	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
O5Y_RS20090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5Y_RS20095	COG3572	ergothioneine biosynthetic process
O5Y_RS20110	COG3976	FMN-binding domain protein
O5Y_RS20110	COG1053	succinate dehydrogenase
O5Y_RS20120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
O5Y_RS20125	COG0193	aminoacyl-tRNA hydrolase activity
O5Y_RS20130	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS20135	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
O5Y_RS20150	COG0259	pyridoxamine-phosphate oxidase activity
O5Y_RS20165	COG1132	(ABC) transporter
O5Y_RS20180	COG2814	Major facilitator Superfamily
O5Y_RS20200	COG1120	ATPase activity
O5Y_RS20205	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS20210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS20230	COG2207	Transcriptional regulator
O5Y_RS20255	COG0488	(ABC) transporter
O5Y_RS20260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
O5Y_RS20285	COG2608	mercury ion transmembrane transporter activity
O5Y_RS20300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
O5Y_RS20305	COG3583	domain protein
O5Y_RS20310	COG3583	domain protein
O5Y_RS20315	COG0765	amino acid transport
O5Y_RS20320	COG1126	abc transporter atp-binding protein
O5Y_RS20330	COG0084	hydrolase, TatD family'
O5Y_RS20355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
O5Y_RS20360	COG2259	Doxx family
O5Y_RS20375	COG1393	Belongs to the ArsC family
O5Y_RS20380	COG2235	arginine
O5Y_RS20385	COG4044	May play a role in the intracellular transport of hydrophobic ligands
O5Y_RS20435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
O5Y_RS20445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
O5Y_RS20450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
O5Y_RS20465	COG1970	mechanosensitive ion channel activity
O5Y_RS20470	COG0521	Mo-molybdopterin cofactor biosynthetic process
O5Y_RS20470	COG0315	cyclic pyranopterin monophosphate synthase activity
O5Y_RS20475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
O5Y_RS20490	COG2860	membrane
O5Y_RS20500	COG0254	rRNA binding
O5Y_RS20510	COG0227	Belongs to the bacterial ribosomal protein bL28 family
O5Y_RS20520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
O5Y_RS20525	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O5Y_RS20570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
O5Y_RS20575	COG2957	Belongs to the agmatine deiminase family
O5Y_RS20585	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
O5Y_RS20630	COG1739	Uncharacterized protein family UPF0029
O5Y_RS20640	COG0045	succinate-CoA ligase (ADP-forming) activity
O5Y_RS20650	COG0739	heme binding
O5Y_RS20690	COG1131	(ABC) transporter
O5Y_RS20705	COG1252	NADH dehydrogenase
O5Y_RS20715	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O5Y_RS20720	COG2272	Belongs to the type-B carboxylesterase lipase family
O5Y_RS20725	COG2272	Belongs to the type-B carboxylesterase lipase family
O5Y_RS20735	COG1396	sequence-specific DNA binding
O5Y_RS20745	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
O5Y_RS20770	COG2814	Major facilitator Superfamily
O5Y_RS20775	COG0583	DNA-binding transcription factor activity
O5Y_RS20780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
O5Y_RS20785	COG3706	GGDEF domain
O5Y_RS20800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
O5Y_RS20835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS20855	COG1113	amino acid transport
O5Y_RS20865	COG1070	Carbohydrate kinase
O5Y_RS20880	COG1940	carbohydrate kinase activity
O5Y_RS20880	COG1846	Transcriptional regulator
O5Y_RS20885	COG0477	Major facilitator Superfamily
O5Y_RS20890	COG1024	Enoyl-CoA hydratase
O5Y_RS20905	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS20965	COG0183	Belongs to the thiolase family
O5Y_RS20970	COG0183	Belongs to the thiolase family
O5Y_RS20975	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS21065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
O5Y_RS21070	COG2175	clavaminate synthase activity
O5Y_RS21080	COG3119	arylsulfatase activity
O5Y_RS21090	COG2205	protein histidine kinase activity
O5Y_RS21125	COG0477	Major facilitator Superfamily
O5Y_RS21155	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O5Y_RS21165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
O5Y_RS21175	COG3279	Response regulator of the LytR AlgR family
O5Y_RS21180	COG3275	phosphorelay sensor kinase activity
O5Y_RS21195	COG0025	NhaP-type Na H and K H
O5Y_RS21210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
O5Y_RS21230	COG2072	flavoprotein involved in K transport
O5Y_RS21235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
O5Y_RS21250	COG2018	Roadblock/LC7 domain
O5Y_RS21285	COG3634	alkyl hydroperoxide reductase activity
O5Y_RS21295	COG1846	Transcriptional regulator
O5Y_RS21300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
O5Y_RS21310	COG0656	L-ascorbic acid biosynthetic process
O5Y_RS21320	COG0488	(ABC) transporter
O5Y_RS21325	COG0656	L-ascorbic acid biosynthetic process
O5Y_RS21335	COG0346	lactoylglutathione lyase activity
O5Y_RS21355	COG4152	abc transporter atp-binding protein
O5Y_RS21360	COG1668	transmembrane transport
O5Y_RS21410	COG2814	Major facilitator Superfamily
O5Y_RS21425	COG0415	Belongs to the DNA photolyase family
O5Y_RS21460	COG0659	secondary active sulfate transmembrane transporter activity
O5Y_RS21465	COG0667	Aldo Keto reductase
O5Y_RS21495	COG3284	Transcriptional regulator
O5Y_RS21500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O5Y_RS21505	COG0508	dehydrogenase complex catalyzes the overall conversion of
O5Y_RS21510	COG0022	dehydrogenase e1 component
O5Y_RS21515	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
O5Y_RS21540	COG0745	RESPONSE REGULATOR receiver
O5Y_RS21545	COG2205	protein histidine kinase activity
O5Y_RS21550	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
O5Y_RS21555	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
O5Y_RS21585	COG0545	Peptidyl-prolyl cis-trans isomerase
O5Y_RS21595	COG2017	converts alpha-aldose to the beta-anomer
O5Y_RS21605	COG0259	pyridoxamine-phosphate oxidase activity
O5Y_RS21615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
O5Y_RS21635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
O5Y_RS21660	COG2252	PERMEase
O5Y_RS21670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
O5Y_RS21695	COG2814	Major facilitator Superfamily
O5Y_RS21705	COG1278	Cold shock
O5Y_RS21725	COG1652	LysM domain
O5Y_RS21755	COG1063	alcohol dehydrogenase
O5Y_RS21760	COG1061	Type III restriction enzyme res subunit
O5Y_RS21775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS21785	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS21805	COG1595	DNA-templated transcription, initiation
O5Y_RS21810	COG1289	transmembrane transporter activity
O5Y_RS21820	COG1309	transcriptional regulator
O5Y_RS21830	COG2072	flavoprotein involved in K transport
O5Y_RS21855	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS21885	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O5Y_RS21905	COG1522	sequence-specific DNA binding
O5Y_RS21910	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
O5Y_RS21920	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
O5Y_RS21955	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS21960	COG1024	Enoyl-CoA hydratase
O5Y_RS21970	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS21975	COG0583	DNA-binding transcription factor activity
O5Y_RS21980	COG0477	Major facilitator Superfamily
O5Y_RS21985	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
O5Y_RS21995	COG0656	L-ascorbic acid biosynthetic process
O5Y_RS22000	COG0673	inositol 2-dehydrogenase activity
O5Y_RS22015	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
O5Y_RS22025	COG4335	DNA alkylation repair
O5Y_RS22040	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS22045	COG0506	proline dehydrogenase activity
O5Y_RS22050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS22075	COG4585	Histidine kinase
O5Y_RS22080	COG2197	response regulator
O5Y_RS22090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
O5Y_RS22100	COG1309	transcriptional regulator
O5Y_RS22130	COG0542	response to heat
O5Y_RS22140	COG2814	Major facilitator Superfamily
O5Y_RS22145	COG2084	Dehydrogenase
O5Y_RS22165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O5Y_RS22185	COG2197	response regulator
O5Y_RS22230	COG1846	Transcriptional regulator
O5Y_RS22235	COG1764	response to oxidative stress
O5Y_RS22240	COG2130	NADP-dependent
O5Y_RS22265	COG2814	Major facilitator Superfamily
O5Y_RS22305	COG1953	Uracil, thiamine, allantoin
O5Y_RS22315	COG2814	Major facilitator Superfamily
O5Y_RS22320	COG0640	Transcriptional regulator
O5Y_RS22340	COG4266	Belongs to the allantoicase family
O5Y_RS22355	COG0564	pseudouridine synthase activity
O5Y_RS22365	COG0589	response to stress
O5Y_RS22375	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS22380	COG1309	transcriptional regulator
O5Y_RS22390	COG0477	Major facilitator Superfamily
O5Y_RS22395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS22400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS22435	COG0477	Major facilitator Superfamily
O5Y_RS22460	COG1309	transcriptional regulator
O5Y_RS22500	COG2814	Major facilitator Superfamily
O5Y_RS22505	COG0583	DNA-binding transcription factor activity
O5Y_RS22535	COG0829	nickel cation binding
O5Y_RS22540	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O5Y_RS22550	COG0804	urea catabolic process
O5Y_RS22555	COG0832	Belongs to the urease beta subunit family
O5Y_RS22560	COG0831	urea catabolic process
O5Y_RS22565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
O5Y_RS22570	COG0581	inorganic phosphate transmembrane transporter activity
O5Y_RS22585	COG0456	acetyltransferase
O5Y_RS22585	COG0454	-acetyltransferase
O5Y_RS22590	COG0745	RESPONSE REGULATOR receiver
O5Y_RS22610	COG2897	thiosulfate sulfurtransferase activity
O5Y_RS22625	COG4044	May play a role in the intracellular transport of hydrophobic ligands
O5Y_RS22635	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
O5Y_RS22640	COG4988	ABC transporter
O5Y_RS22645	COG1294	oxidase, subunit
O5Y_RS22650	COG1271	oxidase subunit
O5Y_RS22660	COG0354	folic acid binding
O5Y_RS22675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
O5Y_RS22715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
O5Y_RS22720	COG2837	iron assimilation
O5Y_RS22725	COG1362	aminopeptidase activity
O5Y_RS22745	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS22750	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
O5Y_RS22755	COG0135	phosphoribosylanthranilate isomerase activity
O5Y_RS22765	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS22775	COG2267	carboxylic ester hydrolase activity
O5Y_RS22780	COG2130	NADP-dependent
O5Y_RS22790	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS22795	COG1609	Transcriptional regulator
O5Y_RS22810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS22815	COG0657	acetylesterase activity
O5Y_RS22830	COG2072	flavoprotein involved in K transport
O5Y_RS22835	COG0300	oxidoreductase activity
O5Y_RS22865	COG4521	taurine ABC transporter
O5Y_RS22870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS22890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
O5Y_RS22900	COG2304	oxidoreductase activity
O5Y_RS22905	COG3706	GGDEF domain
O5Y_RS22985	COG1983	PspC domain protein
O5Y_RS23005	COG1946	Acyl-CoA thioesterase
O5Y_RS23010	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS23015	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23020	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23025	COG1024	Enoyl-CoA hydratase
O5Y_RS23035	COG2814	Major facilitator Superfamily
O5Y_RS23045	COG2030	dehydratase
O5Y_RS23055	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23060	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23065	COG1309	transcriptional regulator
O5Y_RS23070	COG0778	Nitroreductase
O5Y_RS23075	COG1174	glycine betaine transport
O5Y_RS23085	COG1174	glycine betaine transport
O5Y_RS23095	COG4106	trans-aconitate 2-methyltransferase activity
O5Y_RS23105	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23110	COG1946	Acyl-CoA thioesterase
O5Y_RS23115	COG2814	Major facilitator Superfamily
O5Y_RS23120	COG0183	Belongs to the thiolase family
O5Y_RS23125	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23135	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS23145	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23150	COG0183	Belongs to the thiolase family
O5Y_RS23170	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23175	COG1802	Transcriptional regulator
O5Y_RS23180	COG1024	Enoyl-CoA hydratase
O5Y_RS23190	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23195	COG1309	transcriptional regulator
O5Y_RS23210	COG2175	clavaminate synthase activity
O5Y_RS23275	COG1574	metal-dependent hydrolase with the TIM-barrel fold
O5Y_RS23290	COG0488	(ABC) transporter
O5Y_RS23305	COG1053	succinate dehydrogenase
O5Y_RS23315	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23355	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
O5Y_RS23370	COG3590	peptidase
O5Y_RS23375	COG1742	UPF0060 membrane protein
O5Y_RS23380	COG3842	ATPase activity
O5Y_RS23395	COG1175	transmembrane transport
O5Y_RS23400	COG1376	ErfK ybiS ycfS ynhG family protein
O5Y_RS23415	COG3360	Dodecin
O5Y_RS23420	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O5Y_RS23435	COG1793	dna ligase
O5Y_RS23445	COG0598	Magnesium transport protein CorA
O5Y_RS23455	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23470	COG4166	transmembrane transport
O5Y_RS23505	COG4948	Mandelate Racemase Muconate Lactonizing
O5Y_RS23535	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23580	COG1408	metallophosphoesterase
O5Y_RS23600	COG0277	FAD linked oxidase domain protein
O5Y_RS23605	COG2318	DinB family
O5Y_RS23610	COG0326	Molecular chaperone. Has ATPase activity
O5Y_RS23615	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23620	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23640	COG1673	EVE domain
O5Y_RS23655	COG0492	ferredoxin-NADP+ reductase activity
O5Y_RS23670	COG0300	oxidoreductase activity
O5Y_RS23680	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
O5Y_RS23690	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
O5Y_RS23695	COG2079	MmgE PrpD family protein
O5Y_RS23700	COG3800	Transcriptional regulator
O5Y_RS23700	COG1396	sequence-specific DNA binding
O5Y_RS23715	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O5Y_RS23730	COG2271	Major facilitator Superfamily
O5Y_RS23735	COG0667	Aldo Keto reductase
O5Y_RS23760	COG0129	dihydroxy-acid dehydratase activity
O5Y_RS23775	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
O5Y_RS23785	COG0477	Major facilitator Superfamily
O5Y_RS23795	COG3185	4-Hydroxyphenylpyruvate dioxygenase
O5Y_RS23805	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
O5Y_RS23820	COG0583	DNA-binding transcription factor activity
O5Y_RS23830	COG4221	oxidoreductase activity
O5Y_RS23840	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23850	COG2030	dehydratase
O5Y_RS23855	COG0183	Belongs to the thiolase family
O5Y_RS23865	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23875	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS23895	COG2011	ABC-type metal ion transport system permease component
O5Y_RS23935	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23940	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS23950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS23955	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
O5Y_RS23980	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS23990	COG2030	dehydratase
O5Y_RS23995	COG0183	Belongs to the thiolase family
O5Y_RS24000	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24005	COG0183	Belongs to the thiolase family
O5Y_RS24010	COG1309	transcriptional regulator
O5Y_RS24020	COG2015	COG2015, Alkyl sulfatase and related hydrolases
O5Y_RS24045	COG0640	Transcriptional regulator
O5Y_RS24050	COG0174	glutamine synthetase
O5Y_RS24055	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24080	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS24115	COG2902	Dehydrogenase
O5Y_RS24120	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24140	COG2986	histidine ammonia-lyase
O5Y_RS24145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
O5Y_RS24150	COG0277	FAD linked oxidase domain protein
O5Y_RS24155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O5Y_RS24160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
O5Y_RS24165	COG1228	amidohydrolase
O5Y_RS24185	COG1309	transcriptional regulator
O5Y_RS24200	COG2175	clavaminate synthase activity
O5Y_RS24205	COG0789	Transcriptional regulator
O5Y_RS24215	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS24230	COG1309	transcriptional regulator
O5Y_RS24275	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS24290	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS24295	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS24320	COG0604	alcohol dehydrogenase
O5Y_RS24345	COG0640	Transcriptional regulator
O5Y_RS24350	COG0183	Belongs to the thiolase family
O5Y_RS24360	COG2188	Transcriptional regulator
O5Y_RS24370	COG2301	Belongs to the HpcH HpaI aldolase family
O5Y_RS24380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS24385	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24390	COG2271	Major facilitator Superfamily
O5Y_RS24395	COG0183	Belongs to the thiolase family
O5Y_RS24415	COG0583	DNA-binding transcription factor activity
O5Y_RS24420	COG0583	DNA-binding transcription factor activity
O5Y_RS24425	COG1024	Enoyl-CoA hydratase
O5Y_RS24430	COG1024	Enoyl-CoA hydratase
O5Y_RS24435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
O5Y_RS24445	COG0583	DNA-binding transcription factor activity
O5Y_RS24450	COG0583	DNA-binding transcription factor activity
O5Y_RS24460	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24465	COG0183	Belongs to the thiolase family
O5Y_RS24470	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS24480	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24485	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS24490	COG1024	Enoyl-CoA hydratase
O5Y_RS24495	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS24500	COG0653	protein targeting
O5Y_RS24505	COG0653	protein targeting
O5Y_RS24515	COG0028	Belongs to the TPP enzyme family
O5Y_RS24520	COG1024	Enoyl-CoA hydratase
O5Y_RS24555	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS24575	COG1846	Transcriptional regulator
O5Y_RS24585	COG1984	allophanate hydrolase subunit 2
O5Y_RS24595	COG2409	Drug exporters of the RND superfamily
O5Y_RS24605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O5Y_RS24610	COG1595	DNA-templated transcription, initiation
O5Y_RS24615	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
O5Y_RS24625	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS24635	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24640	COG1132	(ABC) transporter
O5Y_RS24645	COG1309	transcriptional regulator
O5Y_RS24650	COG2909	trisaccharide binding
O5Y_RS24680	COG2365	Tyrosine phosphatase family
O5Y_RS24685	COG0697	spore germination
O5Y_RS24690	COG1309	transcriptional regulator
O5Y_RS24695	COG4948	Mandelate Racemase Muconate Lactonizing
O5Y_RS24705	COG2195	Cleaves the N-terminal amino acid of tripeptides
O5Y_RS24715	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O5Y_RS24735	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
O5Y_RS24740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
O5Y_RS24745	COG0601	transmembrane transport
O5Y_RS24750	COG0747	negative chemotaxis
O5Y_RS24775	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS24780	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS24795	COG0277	FAD linked oxidase domain protein
O5Y_RS24800	COG4941	Belongs to the sigma-70 factor family
O5Y_RS24805	COG3795	YCII-related domain
O5Y_RS24820	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS24825	COG1556	Lactate utilization protein
O5Y_RS24830	COG1139	Iron-sulfur cluster binding protein
O5Y_RS24835	COG0247	lactate metabolic process
O5Y_RS24840	COG1802	Transcriptional regulator
O5Y_RS24865	COG1172	Belongs to the binding-protein-dependent transport system permease family
O5Y_RS24890	COG1609	Transcriptional regulator
O5Y_RS24895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
O5Y_RS24915	COG3708	Transcriptional regulator
O5Y_RS24915	COG2207	Transcriptional regulator
O5Y_RS24930	COG3485	protocatechuate 3,4-dioxygenase
O5Y_RS24935	COG3485	protocatechuate 3,4-dioxygenase
O5Y_RS24940	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
O5Y_RS24945	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
O5Y_RS24950	COG1414	Transcriptional regulator
O5Y_RS24980	COG1278	Cold shock
O5Y_RS25005	COG0668	transmembrane transport
O5Y_RS25010	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O5Y_RS25015	COG0590	tRNA wobble adenosine to inosine editing
O5Y_RS25040	COG2267	carboxylic ester hydrolase activity
O5Y_RS25050	COG1305	Transglutaminase-like
O5Y_RS25055	COG0657	acetylesterase activity
O5Y_RS25070	COG3265	gluconokinase activity
O5Y_RS25080	COG2186	Transcriptional regulator
O5Y_RS25085	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
O5Y_RS25090	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS25120	COG2030	dehydratase
O5Y_RS25130	COG2267	carboxylic ester hydrolase activity
O5Y_RS25185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS25205	COG3119	arylsulfatase activity
O5Y_RS25215	COG0531	amino acid
O5Y_RS25225	COG2267	carboxylic ester hydrolase activity
O5Y_RS25245	COG1725	Transcriptional regulator
O5Y_RS25255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS25260	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
O5Y_RS25265	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
O5Y_RS25285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
O5Y_RS25300	COG2132	Multicopper oxidase
O5Y_RS25325	COG1132	(ABC) transporter
O5Y_RS25340	COG2132	Multicopper oxidase
O5Y_RS25390	COG3467	pyridoxamine 5'-phosphate
O5Y_RS25425	COG1959	2 iron, 2 sulfur cluster binding
O5Y_RS25460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
O5Y_RS25470	COG0667	Aldo Keto reductase
O5Y_RS25510	COG3145	DNA-N1-methyladenine dioxygenase activity
O5Y_RS25515	COG0640	Transcriptional regulator
O5Y_RS25540	COG0477	Major facilitator Superfamily
O5Y_RS25555	COG3835	regulator
O5Y_RS25580	COG2197	response regulator
O5Y_RS25585	COG4829	muconolactone delta-isomerase
O5Y_RS25590	COG4948	Mandelate Racemase Muconate Lactonizing
O5Y_RS25595	COG3485	protocatechuate 3,4-dioxygenase
O5Y_RS25600	COG1414	Transcriptional regulator
O5Y_RS25625	COG2084	Dehydrogenase
O5Y_RS25635	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS25645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
O5Y_RS25650	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
O5Y_RS25655	COG0174	glutamine synthetase
O5Y_RS25695	COG2223	nitrite transmembrane transporter activity
O5Y_RS25700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS25710	COG1309	transcriptional regulator
O5Y_RS25715	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
O5Y_RS25720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O5Y_RS25725	COG2814	Major facilitator Superfamily
O5Y_RS25730	COG1063	alcohol dehydrogenase
O5Y_RS25735	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS25740	COG0604	alcohol dehydrogenase
O5Y_RS25760	COG1940	carbohydrate kinase activity
O5Y_RS25765	COG1063	alcohol dehydrogenase
O5Y_RS25785	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS25790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O5Y_RS25820	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
O5Y_RS25840	COG0412	Dienelactone hydrolase
O5Y_RS25845	COG0833	amino acid
O5Y_RS25855	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
O5Y_RS25860	COG1522	sequence-specific DNA binding
O5Y_RS25895	COG0505	Belongs to the CarA family
O5Y_RS25905	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
O5Y_RS25940	COG0183	Belongs to the thiolase family
O5Y_RS25950	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS25955	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS25970	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS25980	COG1024	Enoyl-CoA hydratase
O5Y_RS26000	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26025	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26040	COG1802	Transcriptional regulator
O5Y_RS26045	COG1119	ATPase activity
O5Y_RS26065	COG3706	GGDEF domain
O5Y_RS26070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
O5Y_RS26085	COG1802	Transcriptional regulator
O5Y_RS26110	COG1309	transcriptional regulator
O5Y_RS26155	COG3835	regulator
O5Y_RS26165	COG2814	Major facilitator Superfamily
O5Y_RS26185	COG1053	succinate dehydrogenase
O5Y_RS26195	COG0471	metal ion transport
O5Y_RS26200	COG1652	LysM domain
O5Y_RS26235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
O5Y_RS26240	COG1959	2 iron, 2 sulfur cluster binding
O5Y_RS26245	COG1017	nitric oxide dioxygenase activity
O5Y_RS26245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O5Y_RS26260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
O5Y_RS26265	COG2151	metal-sulfur cluster biosynthetic enzyme
O5Y_RS26270	COG3396	Phenylacetate-CoA oxygenase
O5Y_RS26275	COG3460	Phenylacetate-CoA oxygenase
O5Y_RS26280	COG3396	Phenylacetate-CoA oxygenase
O5Y_RS26285	COG1024	Enoyl-CoA hydratase
O5Y_RS26290	COG1250	3-hydroxyacyl-CoA dehydrogenase
O5Y_RS26295	COG1024	Enoyl-CoA hydratase
O5Y_RS26305	COG2030	dehydratase
O5Y_RS26305	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS26315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
O5Y_RS26315	COG2050	protein possibly involved in aromatic compounds catabolism
O5Y_RS26320	COG3458	cephalosporin-C deacetylase activity
O5Y_RS26345	COG0596	Alpha beta hydrolase
O5Y_RS26350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
O5Y_RS26355	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS26365	COG1113	amino acid transport
O5Y_RS26370	COG2199	diguanylate cyclase activity
O5Y_RS26375	COG5001	Diguanylate cyclase
O5Y_RS26380	COG0477	Major facilitator Superfamily
O5Y_RS26385	COG3552	Protein containing von Willebrand factor type A (VWA) domain
O5Y_RS26395	COG0714	Associated with various cellular activities
O5Y_RS26430	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26460	COG1414	Transcriptional regulator
O5Y_RS26465	COG1252	NADH dehydrogenase
O5Y_RS26470	COG0583	DNA-binding transcription factor activity
O5Y_RS26480	COG0477	Major facilitator Superfamily
O5Y_RS26495	COG0657	acetylesterase activity
O5Y_RS26515	COG4221	oxidoreductase activity
O5Y_RS26525	COG0183	Belongs to the thiolase family
O5Y_RS26535	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26540	COG2814	Major facilitator Superfamily
O5Y_RS26555	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26560	COG1024	Enoyl-CoA hydratase
O5Y_RS26570	COG1072	(Pantothenic acid kinase))
O5Y_RS26580	COG1609	Transcriptional regulator
O5Y_RS26585	COG0657	acetylesterase activity
O5Y_RS26595	COG0477	Major facilitator Superfamily
O5Y_RS26610	COG2186	Transcriptional regulator
O5Y_RS26615	COG2226	methyltransferase
O5Y_RS26620	COG1607	acyl-coa hydrolase
O5Y_RS26665	COG2376	Dihydroxyacetone kinase
O5Y_RS26685	COG0183	Belongs to the thiolase family
O5Y_RS26690	COG0515	serine threonine protein kinase
O5Y_RS26715	COG4221	oxidoreductase activity
O5Y_RS26735	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
O5Y_RS26745	COG4977	sequence-specific DNA binding
O5Y_RS26745	COG1917	Cupin 2, conserved barrel domain protein
O5Y_RS26755	COG2186	Transcriptional regulator
O5Y_RS26770	COG0252	asparaginase activity
O5Y_RS26775	COG2909	trisaccharide binding
O5Y_RS26885	COG2267	carboxylic ester hydrolase activity
O5Y_RS26900	COG1309	transcriptional regulator
O5Y_RS26905	COG1250	3-hydroxyacyl-CoA dehydrogenase
O5Y_RS26915	COG0067	glutamate synthase
O5Y_RS26915	COG0070	glutamate synthase
O5Y_RS26915	COG0069	glutamate synthase activity
O5Y_RS26920	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
O5Y_RS26930	COG1132	(ABC) transporter
O5Y_RS26935	COG1132	(ABC) transporter
O5Y_RS26950	COG2375	cellular response to nickel ion
O5Y_RS26980	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS26990	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS27010	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
O5Y_RS27025	COG3511	phospholipase C
O5Y_RS27035	COG0657	acetylesterase activity
O5Y_RS27040	COG1733	regulation of RNA biosynthetic process
O5Y_RS27070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
O5Y_RS27070	COG2146	nitrite reductase [NAD(P)H] activity
O5Y_RS27085	COG0596	Alpha beta hydrolase
O5Y_RS27095	COG2272	Belongs to the type-B carboxylesterase lipase family
O5Y_RS27100	COG1597	lipid kinase activity
O5Y_RS27115	COG1309	transcriptional regulator
O5Y_RS27130	COG1309	transcriptional regulator
O5Y_RS27135	COG0596	Alpha beta hydrolase
O5Y_RS27155	COG4941	Belongs to the sigma-70 factor family
O5Y_RS27190	COG0406	alpha-ribazole phosphatase activity
O5Y_RS27200	COG1012	belongs to the aldehyde dehydrogenase family
O5Y_RS27225	COG1120	ATPase activity
O5Y_RS27230	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS27235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
O5Y_RS27240	COG4592	Periplasmic binding protein
O5Y_RS27265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
O5Y_RS27290	COG1546	Belongs to the CinA family
O5Y_RS27290	COG1058	Belongs to the CinA family
O5Y_RS27325	COG3973	AAA domain
O5Y_RS27335	COG3971	2-oxopent-4-enoate hydratase activity
O5Y_RS27340	COG4569	acetaldehyde dehydrogenase (acetylating) activity
O5Y_RS27345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
O5Y_RS27355	COG2318	DinB family
O5Y_RS27380	COG0598	Magnesium transport protein CorA
O5Y_RS27425	COG0789	Transcriptional regulator
O5Y_RS27480	COG1028	Short-chain dehydrogenase reductase Sdr
O5Y_RS27490	COG2133	pyrroloquinoline quinone binding
O5Y_RS27510	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS27530	COG0477	Major facilitator Superfamily
O5Y_RS27535	COG0583	DNA-binding transcription factor activity
O5Y_RS27555	COG2226	methyltransferase
O5Y_RS27575	COG1846	Transcriptional regulator
O5Y_RS27580	COG0154	amidase activity
O5Y_RS27595	COG0477	Major facilitator Superfamily
O5Y_RS27625	COG0154	amidase activity
O5Y_RS27650	COG0583	DNA-binding transcription factor activity
O5Y_RS27660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS27680	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS27715	COG1309	transcriptional regulator
O5Y_RS27720	COG0318	PFAM AMP-dependent synthetase and ligase
O5Y_RS27725	COG2072	flavoprotein involved in K transport
O5Y_RS27730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS27765	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
O5Y_RS27800	COG0443	Heat shock 70 kDa protein
O5Y_RS27805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
O5Y_RS27820	COG0542	response to heat
O5Y_RS27830	COG0492	ferredoxin-NADP+ reductase activity
O5Y_RS27850	COG0305	Participates in initiation and elongation during chromosome replication
O5Y_RS27855	COG0359	binds to the 23S rRNA
O5Y_RS27860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
O5Y_RS27870	COG0360	Binds together with S18 to 16S ribosomal RNA
O5Y_RS27890	COG4249	Peptidase C14 caspase catalytic subunit p20
O5Y_RS27890	COG2319	Wd-40 repeat
O5Y_RS27905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O5Y_RS27930	COG1473	amidohydrolase
O5Y_RS27945	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
O5Y_RS27960	COG0251	oxidation-reduction process
O5Y_RS27965	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
O5Y_RS27970	COG1760	l-serine dehydratase
O5Y_RS27980	COG1260	myo-inositol-1-phosphate synthase
O5Y_RS27995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
O5Y_RS28010	COG0330	HflC and HflK could
O5Y_RS28020	COG1414	Transcriptional regulator
O5Y_RS28030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS28035	COG1116	anion transmembrane transporter activity
O5Y_RS28045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS28050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
O5Y_RS28060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O5Y_RS28070	COG0251	oxidation-reduction process
O5Y_RS28075	COG2267	carboxylic ester hydrolase activity
O5Y_RS28085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O5Y_RS28090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS28095	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
O5Y_RS28100	COG1116	anion transmembrane transporter activity
O5Y_RS28100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
O5Y_RS28115	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
O5Y_RS28145	COG2233	PERMEase
O5Y_RS28165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
O5Y_RS28170	COG2508	Transcriptional regulator
O5Y_RS28185	COG2233	PERMEase
O5Y_RS28195	COG3608	succinylglutamate desuccinylase aspartoacylase
O5Y_RS28195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
O5Y_RS28225	COG0154	amidase activity
O5Y_RS28245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
O5Y_RS28270	COG3842	ATPase activity
O5Y_RS28290	COG0740	serine-type endopeptidase activity
O5Y_RS28295	COG0740	serine-type endopeptidase activity
O5Y_RS28305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
O5Y_RS28310	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS28315	COG0477	Major facilitator Superfamily
O5Y_RS28320	COG0583	DNA-binding transcription factor activity
O5Y_RS28325	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS28335	COG1309	transcriptional regulator
O5Y_RS28385	COG0765	amino acid transport
O5Y_RS28390	COG1126	abc transporter atp-binding protein
O5Y_RS28395	COG4941	Belongs to the sigma-70 factor family
O5Y_RS28400	COG3795	YCII-related domain
O5Y_RS28405	COG2197	response regulator
O5Y_RS28420	COG1131	(ABC) transporter
O5Y_RS28445	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
O5Y_RS28465	COG1796	DNA polymerase
O5Y_RS28465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
O5Y_RS28485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
O5Y_RS28490	COG1121	(ABC) transporter
O5Y_RS28495	COG0803	Belongs to the bacterial solute-binding protein 9 family
O5Y_RS28525	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
O5Y_RS28530	COG0508	dehydrogenase complex catalyzes the overall conversion of
O5Y_RS28545	COG1522	sequence-specific DNA binding
O5Y_RS28550	COG3220	belongs to the UPF0276 family
O5Y_RS28565	COG2837	iron assimilation
O5Y_RS28575	COG2267	carboxylic ester hydrolase activity
O5Y_RS28580	COG3631	Ketosteroid isomerase-related protein
O5Y_RS28635	COG0477	Major facilitator Superfamily
O5Y_RS28650	COG0495	leucyl-tRNA aminoacylation
O5Y_RS28665	COG2186	Transcriptional regulator
O5Y_RS28670	COG2814	Major facilitator Superfamily
O5Y_RS28680	COG1678	Uncharacterized ACR, COG1678
O5Y_RS28695	COG0477	Major facilitator Superfamily
O5Y_RS28710	COG1960	acyl-CoA dehydrogenase activity
O5Y_RS28720	COG0617	tRNA 3'-terminal CCA addition
O5Y_RS28770	COG0860	N-Acetylmuramoyl-L-alanine amidase
O5Y_RS28770	COG3409	Peptidoglycan-binding domain 1 protein
O5Y_RS28785	COG1192	Involved in chromosome partitioning
O5Y_RS28790	COG0357	Ribosomal RNA small subunit methyltransferase G
O5Y_RS28815	COG0706	membrane insertase activity
O5Y_RS28820	COG0594	ribonuclease P activity
O5Y_RS28845	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
O5Y_RS28900	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O5Y_RS28905	COG1372	Participates in initiation and elongation during chromosome replication
O5Y_RS28905	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
O5Y_RS29030	COG0515	serine threonine protein kinase
O5Y_RS29400	COG2267	carboxylic ester hydrolase activity