locus-tag	class	description
REQ_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
REQ_RS00010	COG0592	DNA-directed DNA polymerase activity
REQ_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
REQ_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
REQ_RS00045	COG0187	DNA topoisomerase II activity
REQ_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
REQ_RS00070	COG3631	Ketosteroid isomerase-related protein
REQ_RS00075	COG1309	transcriptional regulator
REQ_RS00090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
REQ_RS00095	COG0705	Rhomboid family
REQ_RS00095	COG0457	Tetratricopeptide repeat
REQ_RS00120	COG2815	serine threonine protein kinase
REQ_RS00120	COG0515	serine threonine protein kinase
REQ_RS00125	COG0515	serine threonine protein kinase
REQ_RS00130	COG0768	penicillin binding
REQ_RS00145	COG1716	ATPase activity
REQ_RS00150	COG1716	ATPase activity
REQ_RS00180	COG1733	regulation of RNA biosynthetic process
REQ_RS00205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
REQ_RS00220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
REQ_RS00230	COG0069	glutamate synthase activity
REQ_RS00230	COG0067	glutamate synthase
REQ_RS00230	COG0070	glutamate synthase
REQ_RS00250	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
REQ_RS00265	COG0300	oxidoreductase activity
REQ_RS00270	COG3573	Dehydrogenase
REQ_RS00285	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
REQ_RS00305	COG2501	S4 domain
REQ_RS00330	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS00350	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
REQ_RS00360	COG0154	amidase activity
REQ_RS00375	COG2267	carboxylic ester hydrolase activity
REQ_RS00390	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
REQ_RS00400	COG1309	transcriptional regulator
REQ_RS00430	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS00445	COG0604	alcohol dehydrogenase
REQ_RS00445	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS00445	COG3321	synthase
REQ_RS00450	COG1960	acyl-CoA dehydrogenase activity
REQ_RS00470	COG3559	Exporter of polyketide antibiotics
REQ_RS00475	COG1131	(ABC) transporter
REQ_RS00480	COG1309	transcriptional regulator
REQ_RS00495	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS00515	COG2272	Belongs to the type-B carboxylesterase lipase family
REQ_RS00520	COG0477	Major facilitator Superfamily
REQ_RS00660	COG2197	response regulator
REQ_RS00665	COG4585	Histidine kinase
REQ_RS00685	COG0154	amidase activity
REQ_RS00690	COG1309	transcriptional regulator
REQ_RS00695	COG0346	lactoylglutathione lyase activity
REQ_RS00700	COG1960	acyl-CoA dehydrogenase activity
REQ_RS00720	COG4044	May play a role in the intracellular transport of hydrophobic ligands
REQ_RS00725	COG2119	membrane
REQ_RS00765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
REQ_RS00800	COG1528	Iron-storage protein
REQ_RS00805	COG1528	Iron-storage protein
REQ_RS00810	COG1316	TRANSCRIPTIONal
REQ_RS00820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
REQ_RS00840	COG0077	Prephenate dehydratase
REQ_RS00845	COG0406	alpha-ribazole phosphatase activity
REQ_RS00925	COG0561	phosphatase activity
REQ_RS00935	COG2385	sporulation resulting in formation of a cellular spore
REQ_RS00940	COG0789	Transcriptional regulator
REQ_RS00950	COG1216	Glycosyl transferase, family 2
REQ_RS00955	COG0671	phosphoesterase, PA-phosphatase related
REQ_RS00960	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
REQ_RS00965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
REQ_RS00975	COG5479	isomerase activity
REQ_RS00975	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
REQ_RS00985	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
REQ_RS00995	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS01000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
REQ_RS01000	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
REQ_RS01000	COG3321	synthase
REQ_RS01005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
REQ_RS01035	COG0640	Transcriptional regulator
REQ_RS01050	COG0277	FAD linked oxidase domain protein
REQ_RS01050	COG0247	lactate metabolic process
REQ_RS01105	COG1218	3'(2'),5'-bisphosphate nucleotidase
REQ_RS01110	COG0175	sulfate reduction
REQ_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS01150	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS01155	COG0277	FAD linked oxidase domain protein
REQ_RS01175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
REQ_RS01180	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
REQ_RS01185	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
REQ_RS01190	COG0477	Major facilitator Superfamily
REQ_RS01205	COG0463	Glycosyl transferase, family 2
REQ_RS01230	COG1216	Glycosyl transferase, family 2
REQ_RS01255	COG0604	alcohol dehydrogenase
REQ_RS01270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
REQ_RS01275	COG5479	isomerase activity
REQ_RS01275	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
REQ_RS01280	COG3629	intracellular signal transduction
REQ_RS01285	COG0596	Alpha beta hydrolase
REQ_RS01290	COG0737	Belongs to the 5'-nucleotidase family
REQ_RS01295	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
REQ_RS01335	COG1560	Kdo2-lipid A biosynthetic process
REQ_RS01355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
REQ_RS01360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
REQ_RS01365	COG2080	2 iron, 2 sulfur cluster binding
REQ_RS01370	COG1253	flavin adenine dinucleotide binding
REQ_RS01380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
REQ_RS01385	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS01420	COG2197	response regulator
REQ_RS01435	COG0270	DNA (cytosine-5-)-methyltransferase activity
REQ_RS01445	COG0542	response to heat
REQ_RS01460	COG0154	amidase activity
REQ_RS01465	COG0287	Prephenate dehydrogenase
REQ_RS01475	COG0590	tRNA wobble adenosine to inosine editing
REQ_RS01490	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS01500	COG3193	protein, possibly involved in utilization of glycolate and propanediol
REQ_RS01510	COG1396	sequence-specific DNA binding
REQ_RS01520	COG0546	phosphoglycolate phosphatase activity
REQ_RS01525	COG1216	Glycosyl transferase, family 2
REQ_RS01530	COG1295	ribonuclease BN
REQ_RS01590	COG4106	trans-aconitate 2-methyltransferase activity
REQ_RS01600	COG2409	Drug exporters of the RND superfamily
REQ_RS01615	COG1960	acyl-CoA dehydrogenase activity
REQ_RS01630	COG0330	HflC and HflK could
REQ_RS01660	COG0343	queuine tRNA-ribosyltransferase activity
REQ_RS01665	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
REQ_RS01675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
REQ_RS01680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
REQ_RS01700	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS01710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
REQ_RS01715	COG4592	Periplasmic binding protein
REQ_RS01770	COG1231	oxidoreductase activity
REQ_RS01835	COG0393	Putative heavy-metal-binding
REQ_RS01845	COG4585	Histidine kinase
REQ_RS01850	COG2197	response regulator
REQ_RS01855	COG0154	amidase activity
REQ_RS01860	COG0183	Belongs to the thiolase family
REQ_RS01865	COG1024	Enoyl-CoA hydratase
REQ_RS01865	COG1250	3-hydroxyacyl-CoA dehydrogenase
REQ_RS01870	COG2267	carboxylic ester hydrolase activity
REQ_RS01885	COG1414	Transcriptional regulator
REQ_RS01890	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
REQ_RS01900	COG0747	negative chemotaxis
REQ_RS01915	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
REQ_RS01920	COG0583	DNA-binding transcription factor activity
REQ_RS01940	COG0583	DNA-binding transcription factor activity
REQ_RS01955	COG1960	acyl-CoA dehydrogenase activity
REQ_RS01990	COG1024	Enoyl-CoA hydratase
REQ_RS02000	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
REQ_RS02005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
REQ_RS02055	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
REQ_RS02070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
REQ_RS02075	COG1140	nitrate reductase beta subunit
REQ_RS02110	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
REQ_RS02170	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
REQ_RS02175	COG0251	oxidation-reduction process
REQ_RS02220	COG2132	Multicopper oxidase
REQ_RS02225	COG0640	Transcriptional regulator
REQ_RS02230	COG0798	PFAM Bile acid sodium symporter
REQ_RS02235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
REQ_RS02255	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
REQ_RS02255	COG1473	amidohydrolase
REQ_RS02260	COG0367	asparagine synthase
REQ_RS02270	COG1473	amidohydrolase
REQ_RS02270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
REQ_RS02285	COG0596	Alpha beta hydrolase
REQ_RS02290	COG1414	Transcriptional regulator
REQ_RS02300	COG1309	transcriptional regulator
REQ_RS02370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
REQ_RS02385	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
REQ_RS02395	COG0583	DNA-binding transcription factor activity
REQ_RS02405	COG1408	metallophosphoesterase
REQ_RS02420	COG0693	protein deglycase activity
REQ_RS02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
REQ_RS02445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
REQ_RS02470	COG1917	Cupin 2, conserved barrel domain protein
REQ_RS02480	COG0477	Major facilitator Superfamily
REQ_RS02485	COG0583	DNA-binding transcription factor activity
REQ_RS02505	COG0833	amino acid
REQ_RS02520	COG3118	belongs to the thioredoxin family
REQ_RS02525	COG0494	nUDIX hydrolase
REQ_RS02535	COG0596	Alpha beta hydrolase
REQ_RS02545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
REQ_RS02550	COG0477	Major facilitator Superfamily
REQ_RS02570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
REQ_RS02580	COG0601	transmembrane transport
REQ_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
REQ_RS02640	COG1111	helicase
REQ_RS02640	COG1205	dead DEAH box helicase
REQ_RS02645	COG1278	Cold shock
REQ_RS02655	COG1754	DNA topoisomerase type I activity
REQ_RS02655	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
REQ_RS02690	COG2186	Transcriptional regulator
REQ_RS02695	COG1119	ATPase activity
REQ_RS02725	COG4941	Belongs to the sigma-70 factor family
REQ_RS02755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
REQ_RS02760	COG0442	prolyl-tRNA aminoacylation
REQ_RS02785	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
REQ_RS02800	COG1595	DNA-templated transcription, initiation
REQ_RS02810	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
REQ_RS02820	COG2027	D-alanyl-D-alanine carboxypeptidase
REQ_RS02830	COG0037	tRNA processing
REQ_RS02840	COG0515	serine threonine protein kinase
REQ_RS02840	COG2815	serine threonine protein kinase
REQ_RS02850	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
REQ_RS02855	COG0302	gtp cyclohydrolase
REQ_RS02860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
REQ_RS02890	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
REQ_RS02895	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
REQ_RS02900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
REQ_RS02915	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
REQ_RS02950	COG0477	Major facilitator Superfamily
REQ_RS03000	COG4585	Histidine kinase
REQ_RS03005	COG2197	response regulator
REQ_RS03010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
REQ_RS03040	COG1194	a g-specific adenine glycosylase
REQ_RS03045	COG0288	reversible hydration of carbon dioxide
REQ_RS03055	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
REQ_RS03065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
REQ_RS03080	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
REQ_RS03085	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
REQ_RS03100	COG1984	allophanate hydrolase subunit 2
REQ_RS03110	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
REQ_RS03125	COG1396	sequence-specific DNA binding
REQ_RS03135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
REQ_RS03140	COG0456	acetyltransferase
REQ_RS03145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
REQ_RS03150	COG1121	(ABC) transporter
REQ_RS03160	COG1609	Transcriptional regulator
REQ_RS03165	COG3387	PFAM Glycoside hydrolase 15-related
REQ_RS03170	COG1309	transcriptional regulator
REQ_RS03175	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03180	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03185	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03190	COG2030	dehydratase
REQ_RS03205	COG0657	acetylesterase activity
REQ_RS03210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS03215	COG0667	Aldo Keto reductase
REQ_RS03220	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03240	COG1414	Transcriptional regulator
REQ_RS03255	COG0477	Major facilitator Superfamily
REQ_RS03260	COG2175	clavaminate synthase activity
REQ_RS03270	COG2149	membrane
REQ_RS03300	COG2030	dehydratase
REQ_RS03305	COG1053	succinate dehydrogenase
REQ_RS03320	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03325	COG2267	carboxylic ester hydrolase activity
REQ_RS03330	COG0346	lactoylglutathione lyase activity
REQ_RS03335	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
REQ_RS03360	COG2124	cytochrome p450
REQ_RS03385	COG0656	L-ascorbic acid biosynthetic process
REQ_RS03400	COG0561	phosphatase activity
REQ_RS03410	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03415	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03420	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03425	COG1024	Enoyl-CoA hydratase
REQ_RS03430	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS03435	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03440	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03445	COG1309	transcriptional regulator
REQ_RS03450	COG0183	Belongs to the thiolase family
REQ_RS03455	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
REQ_RS03510	COG1024	Enoyl-CoA hydratase
REQ_RS03515	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03520	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03535	COG0183	Belongs to the thiolase family
REQ_RS03540	COG2124	cytochrome p450
REQ_RS03555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
REQ_RS03560	COG0183	Belongs to the thiolase family
REQ_RS03570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS03580	COG0183	Belongs to the thiolase family
REQ_RS03590	COG1024	Enoyl-CoA hydratase
REQ_RS03600	COG2070	2-Nitropropane dioxygenase
REQ_RS03605	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS03610	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03615	COG1960	acyl-CoA dehydrogenase activity
REQ_RS03625	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
REQ_RS03660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
REQ_RS03680	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
REQ_RS03690	COG1132	(ABC) transporter
REQ_RS03700	COG2365	Tyrosine phosphatase family
REQ_RS03730	COG3486	L-lysine 6-monooxygenase (NADPH) activity
REQ_RS03780	COG0492	ferredoxin-NADP+ reductase activity
REQ_RS03785	COG1396	sequence-specific DNA binding
REQ_RS03805	COG0745	RESPONSE REGULATOR receiver
REQ_RS03810	COG2205	protein histidine kinase activity
REQ_RS03815	COG0537	adenosine 5'-monophosphoramidase activity
REQ_RS03830	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
REQ_RS03840	COG5285	phytanoyl-CoA dioxygenase
REQ_RS03850	COG0436	Aminotransferase
REQ_RS03855	COG3226	Transcriptional regulator
REQ_RS03860	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
REQ_RS03870	COG1846	Transcriptional regulator
REQ_RS03875	COG1132	(ABC) transporter
REQ_RS03880	COG1053	succinate dehydrogenase
REQ_RS03880	COG3976	FMN-binding domain protein
REQ_RS03900	COG2515	1-aminocyclopropane-1-carboxylate deaminase
REQ_RS03905	COG2076	Multidrug Resistance protein
REQ_RS03930	COG1120	ATPase activity
REQ_RS03935	COG4139	cobalamin transport
REQ_RS03950	COG0477	Major facilitator Superfamily
REQ_RS03965	COG3433	isochorismatase activity
REQ_RS03965	COG1535	isochorismatase
REQ_RS03970	COG1021	2,3-dihydroxybenzoate-AMP ligase
REQ_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS03985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
REQ_RS04000	COG1535	isochorismatase
REQ_RS04000	COG3433	isochorismatase activity
REQ_RS04015	COG0477	Major facilitator Superfamily
REQ_RS04020	COG0386	Belongs to the glutathione peroxidase family
REQ_RS04045	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
REQ_RS04050	COG0047	phosphoribosylformylglycinamidine synthase activity
REQ_RS04055	COG4565	transcriptional regulatory protein
REQ_RS04060	COG3290	protein histidine kinase activity
REQ_RS04065	COG1301	dicarboxylic acid transport
REQ_RS04085	COG1362	aminopeptidase activity
REQ_RS04090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
REQ_RS04105	COG3467	pyridoxamine 5'-phosphate
REQ_RS04120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
REQ_RS04130	COG2258	MOSC domain
REQ_RS04135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
REQ_RS04145	COG1271	oxidase subunit
REQ_RS04150	COG1294	oxidase, subunit
REQ_RS04155	COG4988	ABC transporter
REQ_RS04160	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
REQ_RS04170	COG4044	May play a role in the intracellular transport of hydrophobic ligands
REQ_RS04190	COG2897	thiosulfate sulfurtransferase activity
REQ_RS04200	COG4232	protein-disulfide reductase activity
REQ_RS04210	COG0745	RESPONSE REGULATOR receiver
REQ_RS04230	COG0581	inorganic phosphate transmembrane transporter activity
REQ_RS04235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
REQ_RS04275	COG0583	DNA-binding transcription factor activity
REQ_RS04280	COG2814	Major facilitator Superfamily
REQ_RS04340	COG1309	transcriptional regulator
REQ_RS04345	COG1960	acyl-CoA dehydrogenase activity
REQ_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS04365	COG0564	pseudouridine synthase activity
REQ_RS04370	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
REQ_RS04390	COG0542	response to heat
REQ_RS04395	COG1309	transcriptional regulator
REQ_RS04420	COG2135	peptidase activity
REQ_RS04440	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
REQ_RS04445	COG2079	MmgE PrpD family protein
REQ_RS04450	COG3800	Transcriptional regulator
REQ_RS04450	COG1396	sequence-specific DNA binding
REQ_RS04460	COG2084	Dehydrogenase
REQ_RS04465	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
REQ_RS04480	COG2124	cytochrome p450
REQ_RS04500	COG0640	Transcriptional regulator
REQ_RS04505	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
REQ_RS04515	COG0657	acetylesterase activity
REQ_RS04530	COG4251	negative regulation of phosphorylation
REQ_RS04535	COG0784	Response regulator, receiver
REQ_RS04565	COG1366	Belongs to the anti-sigma-factor antagonist family
REQ_RS04590	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
REQ_RS04595	COG1595	DNA-templated transcription, initiation
REQ_RS04610	COG0463	Glycosyl transferase, family 2
REQ_RS04625	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
REQ_RS04635	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
REQ_RS04710	COG0681	Belongs to the peptidase S26 family
REQ_RS04730	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
REQ_RS04735	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
REQ_RS04740	COG1278	Cold shock
REQ_RS04770	COG0671	phosphoesterase, PA-phosphatase related
REQ_RS04780	COG2252	PERMEase
REQ_RS04790	COG2814	Major facilitator Superfamily
REQ_RS04825	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
REQ_RS04835	COG0259	pyridoxamine-phosphate oxidase activity
REQ_RS04855	COG0545	Peptidyl-prolyl cis-trans isomerase
REQ_RS04885	COG0179	Fumarylacetoacetate (FAA) hydrolase
REQ_RS04895	COG0415	Belongs to the DNA photolyase family
REQ_RS04950	COG2130	NADP-dependent
REQ_RS04960	COG1309	transcriptional regulator
REQ_RS04970	COG1668	transmembrane transport
REQ_RS04975	COG4152	abc transporter atp-binding protein
REQ_RS04995	COG2847	Copper chaperone PCu(A)C
REQ_RS05000	COG2837	iron assimilation
REQ_RS05005	COG0488	(ABC) transporter
REQ_RS05020	COG1024	Enoyl-CoA hydratase
REQ_RS05030	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS05040	COG1053	succinate dehydrogenase
REQ_RS05050	COG0656	L-ascorbic acid biosynthetic process
REQ_RS05065	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
REQ_RS05110	COG1472	Belongs to the glycosyl hydrolase 3 family
REQ_RS05115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
REQ_RS05145	COG3275	phosphorelay sensor kinase activity
REQ_RS05150	COG3279	Response regulator of the LytR AlgR family
REQ_RS05160	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
REQ_RS05170	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
REQ_RS05180	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
REQ_RS05205	COG2271	Major facilitator Superfamily
REQ_RS05225	COG2175	clavaminate synthase activity
REQ_RS05230	COG3246	L-lysine catabolic process to acetate
REQ_RS05240	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS05255	COG1960	acyl-CoA dehydrogenase activity
REQ_RS05270	COG0789	Transcriptional regulator
REQ_RS05320	COG2837	iron assimilation
REQ_RS05325	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
REQ_RS05325	COG1017	nitric oxide dioxygenase activity
REQ_RS05330	COG1959	2 iron, 2 sulfur cluster binding
REQ_RS05340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS05350	COG1289	transmembrane transporter activity
REQ_RS05360	COG0772	Belongs to the SEDS family
REQ_RS05370	COG0326	Molecular chaperone. Has ATPase activity
REQ_RS05420	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
REQ_RS05430	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
REQ_RS05440	COG2272	Belongs to the type-B carboxylesterase lipase family
REQ_RS05445	COG2272	Belongs to the type-B carboxylesterase lipase family
REQ_RS05460	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS05475	COG2226	methyltransferase
REQ_RS05480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
REQ_RS05520	COG0166	Belongs to the GPI family
REQ_RS05540	COG0739	heme binding
REQ_RS05545	COG0045	succinate-CoA ligase (ADP-forming) activity
REQ_RS05555	COG1739	Uncharacterized protein family UPF0029
REQ_RS05590	COG1073	alpha beta
REQ_RS05595	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
REQ_RS05605	COG0346	lactoylglutathione lyase activity
REQ_RS05610	COG0640	Transcriptional regulator
REQ_RS05640	COG3119	arylsulfatase activity
REQ_RS05645	COG1120	ATPase activity
REQ_RS05660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
REQ_RS05665	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
REQ_RS05675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
REQ_RS05695	COG2860	membrane
REQ_RS05710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
REQ_RS05715	COG0521	Mo-molybdopterin cofactor biosynthetic process
REQ_RS05715	COG0315	cyclic pyranopterin monophosphate synthase activity
REQ_RS05720	COG1970	mechanosensitive ion channel activity
REQ_RS05735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
REQ_RS05740	COG1210	Utp--glucose-1-phosphate uridylyltransferase
REQ_RS05750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
REQ_RS05780	COG1136	(ABC) transporter
REQ_RS05795	COG2197	response regulator
REQ_RS05825	COG1725	Transcriptional regulator
REQ_RS05830	COG2259	Doxx family
REQ_RS05835	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
REQ_RS05855	COG2319	Wd-40 repeat
REQ_RS05855	COG4249	Peptidase C14 caspase catalytic subunit p20
REQ_RS05860	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
REQ_RS05875	COG0084	hydrolase, TatD family'
REQ_RS05885	COG3583	domain protein
REQ_RS05890	COG3583	domain protein
REQ_RS05895	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
REQ_RS05955	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
REQ_RS05960	COG0488	(ABC) transporter
REQ_RS06005	COG2814	Major facilitator Superfamily
REQ_RS06010	COG1846	Transcriptional regulator
REQ_RS06020	COG3201	nicotinamide mononucleotide transporter
REQ_RS06025	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
REQ_RS06030	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS06035	COG0709	Synthesizes selenophosphate from selenide and ATP
REQ_RS06045	COG1921	L-seryl-tRNASec selenium transferase activity
REQ_RS06060	COG0437	4 iron, 4 sulfur cluster binding
REQ_RS06065	COG3383	formate dehydrogenase (NAD+) activity
REQ_RS06065	COG0243	molybdopterin cofactor binding
REQ_RS06070	COG0243	molybdopterin cofactor binding
REQ_RS06070	COG3383	formate dehydrogenase (NAD+) activity
REQ_RS06085	COG1053	succinate dehydrogenase
REQ_RS06095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
REQ_RS06100	COG3572	ergothioneine biosynthetic process
REQ_RS06105	COG1262	PFAM Formylglycine-generating sulfatase enzyme
REQ_RS06110	COG0121	glutamine amidotransferase
REQ_RS06150	COG1309	transcriptional regulator
REQ_RS06160	COG3956	TIGRFAM MazG family protein
REQ_RS06165	COG0488	(ABC) transporter
REQ_RS06170	COG2837	iron assimilation
REQ_RS06180	COG0672	)-iron permease
REQ_RS06190	COG0148	phosphopyruvate hydratase activity
REQ_RS06225	COG1278	Cold shock
REQ_RS06235	COG1960	acyl-CoA dehydrogenase activity
REQ_RS06240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS06270	COG0183	Belongs to the thiolase family
REQ_RS06275	COG2755	lipolytic protein G-D-S-L family
REQ_RS06295	COG0653	protein targeting
REQ_RS06300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
REQ_RS06310	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
REQ_RS06320	COG1331	Highly conserved protein containing a thioredoxin domain
REQ_RS06345	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
REQ_RS06365	COG1072	(Pantothenic acid kinase))
REQ_RS06375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
REQ_RS06385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
REQ_RS06390	COG1053	succinate dehydrogenase
REQ_RS06400	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
REQ_RS06420	COG1722	exodeoxyribonuclease VII activity
REQ_RS06425	COG1570	exodeoxyribonuclease VII activity
REQ_RS06445	COG0420	3'-5' exonuclease activity
REQ_RS06450	COG0419	ATPase involved in DNA repair
REQ_RS06465	COG0069	glutamate synthase activity
REQ_RS06485	COG2226	methyltransferase
REQ_RS06495	COG0012	GTP binding
REQ_RS06515	COG0493	'glutamate synthase
REQ_RS06520	COG0564	pseudouridine synthase activity
REQ_RS06535	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
REQ_RS06540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
REQ_RS06545	COG1116	anion transmembrane transporter activity
REQ_RS06550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS06565	COG1690	Belongs to the RtcB family
REQ_RS06575	COG4221	oxidoreductase activity
REQ_RS06605	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
REQ_RS06605	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
REQ_RS06620	COG2072	flavoprotein involved in K transport
REQ_RS06645	COG0657	acetylesterase activity
REQ_RS06650	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS06660	COG0657	acetylesterase activity
REQ_RS06695	COG0028	Belongs to the TPP enzyme family
REQ_RS06700	COG1053	succinate dehydrogenase
REQ_RS06725	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS06785	COG1574	metal-dependent hydrolase with the TIM-barrel fold
REQ_RS06795	COG1309	transcriptional regulator
REQ_RS06800	COG1053	succinate dehydrogenase
REQ_RS06810	COG3757	hydrolase, family 25
REQ_RS06830	COG0477	Major facilitator Superfamily
REQ_RS06835	COG1846	Transcriptional regulator
REQ_RS06850	COG1051	belongs to the nudix hydrolase family
REQ_RS06855	COG2154	pterin-4-alpha-carbinolamine dehydratase
REQ_RS06870	COG1217	gtp-binding protein TYPA
REQ_RS06880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
REQ_RS06905	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
REQ_RS06910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
REQ_RS06915	COG0028	Belongs to the TPP enzyme family
REQ_RS06930	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS06935	COG0506	proline dehydrogenase activity
REQ_RS06940	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS06950	COG2130	NADP-dependent
REQ_RS06955	COG2175	clavaminate synthase activity
REQ_RS06975	COG1113	amino acid transport
REQ_RS06980	COG2171	N-acyltransferase activity
REQ_RS06985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
REQ_RS06990	COG1611	Belongs to the LOG family
REQ_RS06995	COG1611	Belongs to the LOG family
REQ_RS07000	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS07005	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
REQ_RS07010	COG0463	Glycosyl transferase, family 2
REQ_RS07020	COG0519	Catalyzes the synthesis of GMP from XMP
REQ_RS07030	COG0297	glycogen (starch) synthase activity
REQ_RS07035	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
REQ_RS07040	COG4122	O-methyltransferase activity
REQ_RS07045	COG1595	DNA-templated transcription, initiation
REQ_RS07050	COG5662	AntiSigma factor
REQ_RS07055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
REQ_RS07080	COG2239	Acts as a magnesium transporter
REQ_RS07085	COG2301	Belongs to the HpcH HpaI aldolase family
REQ_RS07095	COG2814	Major facilitator Superfamily
REQ_RS07105	COG0613	PHP domain protein
REQ_RS07130	COG1174	glycine betaine transport
REQ_RS07165	COG1309	transcriptional regulator
REQ_RS07170	COG0567	Dehydrogenase, E1 component
REQ_RS07170	COG0508	dehydrogenase complex catalyzes the overall conversion of
REQ_RS07175	COG1132	(ABC) transporter
REQ_RS07215	COG0435	Glutathione S-transferase
REQ_RS07230	COG0596	Alpha beta hydrolase
REQ_RS07235	COG1024	Enoyl-CoA hydratase
REQ_RS07240	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS07245	COG1024	Enoyl-CoA hydratase
REQ_RS07250	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
REQ_RS07265	COG0783	Belongs to the Dps family
REQ_RS07275	COG0477	Major facilitator Superfamily
REQ_RS07340	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
REQ_RS07355	COG1132	(ABC) transporter
REQ_RS07385	COG1136	(ABC) transporter
REQ_RS07390	COG0577	efflux transmembrane transporter activity
REQ_RS07390	COG1136	(ABC) transporter
REQ_RS07445	COG0574	Belongs to the PEP-utilizing enzyme family
REQ_RS07445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
REQ_RS07455	COG1960	acyl-CoA dehydrogenase activity
REQ_RS07475	COG3973	AAA domain
REQ_RS07480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
REQ_RS07485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
REQ_RS07490	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS07510	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
REQ_RS07540	COG1960	acyl-CoA dehydrogenase activity
REQ_RS07545	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS07550	COG1309	transcriptional regulator
REQ_RS07565	COG1414	Transcriptional regulator
REQ_RS07575	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS07580	COG1309	transcriptional regulator
REQ_RS07585	COG1024	Enoyl-CoA hydratase
REQ_RS07605	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS07640	COG1063	alcohol dehydrogenase
REQ_RS07680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
REQ_RS07710	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
REQ_RS07725	COG1053	succinate dehydrogenase
REQ_RS07740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
REQ_RS07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
REQ_RS07750	COG0351	phosphomethylpyrimidine kinase
REQ_RS07750	COG0352	thiamine-phosphate diphosphorylase activity
REQ_RS07750	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
REQ_RS07780	COG0577	efflux transmembrane transporter activity
REQ_RS07780	COG1136	(ABC) transporter
REQ_RS07790	COG2764	glyoxalase bleomycin resistance protein dioxygenase
REQ_RS07800	COG2197	response regulator
REQ_RS07825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
REQ_RS07830	COG1116	anion transmembrane transporter activity
REQ_RS07840	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS07845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS07855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
REQ_RS07875	COG1024	Enoyl-CoA hydratase
REQ_RS07890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
REQ_RS07950	COG1802	Transcriptional regulator
REQ_RS07955	COG1620	l-lactate permease
REQ_RS07960	COG0247	lactate metabolic process
REQ_RS07965	COG1139	Iron-sulfur cluster binding protein
REQ_RS07970	COG1556	Lactate utilization protein
REQ_RS08005	COG1074	ATP-dependent DNA helicase activity
REQ_RS08045	COG0330	HflC and HflK could
REQ_RS08070	COG0210	DNA helicase
REQ_RS08080	COG1201	RNA secondary structure unwinding
REQ_RS08095	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
REQ_RS08155	COG0277	FAD linked oxidase domain protein
REQ_RS08235	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS08240	COG3189	MarR family transcriptional regulator
REQ_RS08260	COG2223	nitrite transmembrane transporter activity
REQ_RS08265	COG0508	dehydrogenase complex catalyzes the overall conversion of
REQ_RS08270	COG0022	dehydrogenase e1 component
REQ_RS08280	COG1522	sequence-specific DNA binding
REQ_RS08300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
REQ_RS08315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
REQ_RS08320	COG4279	zinc finger
REQ_RS08365	COG3408	Glycogen debranching enzyme
REQ_RS08365	COG3119	arylsulfatase activity
REQ_RS08375	COG1960	acyl-CoA dehydrogenase activity
REQ_RS08380	COG1960	acyl-CoA dehydrogenase activity
REQ_RS08385	COG1024	Enoyl-CoA hydratase
REQ_RS08410	COG1846	Transcriptional regulator
REQ_RS08420	COG2814	Major facilitator Superfamily
REQ_RS08460	COG1218	3'(2'),5'-bisphosphate nucleotidase
REQ_RS08470	COG0640	Transcriptional regulator
REQ_RS08480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS08510	COG0019	diaminopimelate decarboxylase activity
REQ_RS08515	COG0460	homoserine dehydrogenase
REQ_RS08520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
REQ_RS08535	COG0254	rRNA binding
REQ_RS08540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
REQ_RS08550	COG2890	protein-(glutamine-N5) methyltransferase activity
REQ_RS08560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
REQ_RS08570	COG0356	it plays a direct role in the translocation of protons across the membrane
REQ_RS08575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
REQ_RS08580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
REQ_RS08585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
REQ_RS08590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
REQ_RS08605	COG0355	proton-transporting ATP synthase activity, rotational mechanism
REQ_RS08620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
REQ_RS08645	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
REQ_RS08655	COG0346	lactoylglutathione lyase activity
REQ_RS08660	COG0183	Belongs to the thiolase family
REQ_RS08665	COG2409	Drug exporters of the RND superfamily
REQ_RS08680	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
REQ_RS08685	COG0366	Alpha amylase catalytic
REQ_RS08690	COG0058	SHG alpha-glucan phosphorylase activity
REQ_RS08700	COG3559	Exporter of polyketide antibiotics
REQ_RS08705	COG1131	(ABC) transporter
REQ_RS08725	COG1335	isochorismatase
REQ_RS08730	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
REQ_RS08755	COG1234	tRNA 3'-trailer cleavage
REQ_RS08760	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
REQ_RS08765	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
REQ_RS08780	COG0228	four-way junction DNA binding
REQ_RS08790	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
REQ_RS08795	COG0336	Belongs to the RNA methyltransferase TrmD family
REQ_RS08800	COG1231	oxidoreductase activity
REQ_RS08810	COG2183	response to ionizing radiation
REQ_RS08820	COG1262	PFAM Formylglycine-generating sulfatase enzyme
REQ_RS08840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
REQ_RS08850	COG0792	nuclease activity
REQ_RS08865	COG2030	dehydratase
REQ_RS08880	COG2814	Major facilitator Superfamily
REQ_RS08900	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
REQ_RS08905	COG0528	UMP kinase activity
REQ_RS08910	COG0233	cytoplasmic translational termination
REQ_RS08915	COG0575	Belongs to the CDS family
REQ_RS08920	COG2226	methyltransferase
REQ_RS08950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
REQ_RS08955	COG0750	zinc metalloprotease
REQ_RS09025	COG2197	response regulator
REQ_RS09030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
REQ_RS09070	COG2188	Transcriptional regulator
REQ_RS09115	COG0659	secondary active sulfate transmembrane transporter activity
REQ_RS09125	COG1464	Belongs to the NlpA lipoprotein family
REQ_RS09130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
REQ_RS09135	COG2011	ABC-type metal ion transport system permease component
REQ_RS09155	COG0579	oxidoreductase
REQ_RS09180	COG1648	precorrin-2 dehydrogenase activity
REQ_RS09180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
REQ_RS09190	COG0697	spore germination
REQ_RS09195	COG3022	response to hydroperoxide
REQ_RS09210	COG0442	prolyl-tRNA aminoacylation
REQ_RS09215	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS09220	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS09225	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS09270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
REQ_RS09275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
REQ_RS09280	COG0649	NAD binding
REQ_RS09290	COG1034	ATP synthesis coupled electron transport
REQ_RS09295	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
REQ_RS09300	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
REQ_RS09310	COG0713	ATP synthesis coupled electron transport
REQ_RS09335	COG0477	Major facilitator Superfamily
REQ_RS09370	COG1550	Protein conserved in bacteria
REQ_RS09375	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
REQ_RS09380	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
REQ_RS09390	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
REQ_RS09400	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
REQ_RS09420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
REQ_RS09425	COG1185	polyribonucleotide nucleotidyltransferase activity
REQ_RS09430	COG0612	Peptidase, M16
REQ_RS09435	COG3119	arylsulfatase activity
REQ_RS09440	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
REQ_RS09445	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
REQ_RS09475	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS09485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
REQ_RS09490	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
REQ_RS09525	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
REQ_RS09540	COG1396	sequence-specific DNA binding
REQ_RS09545	COG1842	Phage shock protein A
REQ_RS09560	COG1122	ATPase activity
REQ_RS09565	COG1268	BioY protein
REQ_RS09580	COG2814	Major facilitator Superfamily
REQ_RS09585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
REQ_RS09595	COG0277	FAD linked oxidase domain protein
REQ_RS09610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS09625	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
REQ_RS09630	COG2137	regulation of response to DNA damage stimulus
REQ_RS09640	COG0765	amino acid transport
REQ_RS09645	COG0765	amino acid transport
REQ_RS09650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
REQ_RS09655	COG1126	abc transporter atp-binding protein
REQ_RS09660	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
REQ_RS09670	COG1196	nuclear chromosome segregation
REQ_RS09680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
REQ_RS09690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
REQ_RS09705	COG2233	PERMEase
REQ_RS09710	COG1960	acyl-CoA dehydrogenase activity
REQ_RS09730	COG1643	Atp-dependent helicase
REQ_RS09735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
REQ_RS09740	COG1609	Transcriptional regulator
REQ_RS09745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
REQ_RS09750	COG1129	ABC transporter
REQ_RS09770	COG1388	LysM domain
REQ_RS09780	COG0583	DNA-binding transcription factor activity
REQ_RS09805	COG4581	dead DEAH box helicase
REQ_RS09840	COG0123	including yeast histone deacetylase and acetoin utilization protein
REQ_RS09845	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
REQ_RS09845	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
REQ_RS09855	COG2890	protein-(glutamine-N5) methyltransferase activity
REQ_RS09895	COG0475	glutathione-regulated potassium exporter activity
REQ_RS09930	COG0756	dUTP diphosphatase activity
REQ_RS09960	COG0569	domain protein
REQ_RS09965	COG0531	amino acid
REQ_RS09970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
REQ_RS09980	COG0477	Major facilitator Superfamily
REQ_RS09995	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
REQ_RS09995	COG2066	Belongs to the glutaminase family
REQ_RS10000	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
REQ_RS10005	COG4716	Myosin-crossreactive antigen
REQ_RS10010	COG1357	PFAM Pentapeptide repeats (8 copies)
REQ_RS10015	COG0477	Major facilitator Superfamily
REQ_RS10025	COG1250	3-hydroxyacyl-CoA dehydrogenase
REQ_RS10025	COG1024	Enoyl-CoA hydratase
REQ_RS10030	COG0183	Belongs to the thiolase family
REQ_RS10050	COG0657	acetylesterase activity
REQ_RS10070	COG3253	May function as heme-dependent peroxidase
REQ_RS10090	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
REQ_RS10120	COG2223	nitrite transmembrane transporter activity
REQ_RS10125	COG2723	6-phospho-beta-galactosidase activity
REQ_RS10170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
REQ_RS10185	COG1560	Kdo2-lipid A biosynthetic process
REQ_RS10190	COG0438	transferase activity, transferring glycosyl groups
REQ_RS10200	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
REQ_RS10205	COG1946	Acyl-CoA thioesterase
REQ_RS10210	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
REQ_RS10230	COG0632	four-way junction helicase activity
REQ_RS10235	COG2255	four-way junction helicase activity
REQ_RS10250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
REQ_RS10255	COG0747	negative chemotaxis
REQ_RS10260	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
REQ_RS10265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
REQ_RS10270	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
REQ_RS10275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
REQ_RS10285	COG0124	histidyl-tRNA synthetase
REQ_RS10300	COG0039	L-malate dehydrogenase activity
REQ_RS10335	COG1984	allophanate hydrolase subunit 2
REQ_RS10340	COG2814	Major facilitator Superfamily
REQ_RS10345	COG1309	transcriptional regulator
REQ_RS10370	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS10410	COG2132	Multicopper oxidase
REQ_RS10430	COG0739	heme binding
REQ_RS10445	COG0183	Belongs to the thiolase family
REQ_RS10485	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
REQ_RS10495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
REQ_RS10505	COG0747	negative chemotaxis
REQ_RS10520	COG2175	clavaminate synthase activity
REQ_RS10525	COG1309	transcriptional regulator
REQ_RS10535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
REQ_RS10540	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
REQ_RS10545	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
REQ_RS10550	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
REQ_RS10555	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
REQ_RS10560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
REQ_RS10580	COG0006	proline dipeptidase activity
REQ_RS10585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
REQ_RS10595	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
REQ_RS10600	COG0540	Belongs to the ATCase OTCase family
REQ_RS10615	COG0505	Belongs to the CarA family
REQ_RS10620	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
REQ_RS10625	COG0284	orotidine-5'-phosphate decarboxylase activity
REQ_RS10635	COG0194	GDP metabolic process
REQ_RS10640	COG1758	RNA polymerase activity
REQ_RS10650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
REQ_RS10665	COG0598	Magnesium transport protein CorA
REQ_RS10720	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
REQ_RS10750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
REQ_RS10750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
REQ_RS10765	COG0322	excinuclease ABC activity
REQ_RS10770	COG1660	Displays ATPase and GTPase activities
REQ_RS10780	COG1481	regulation of sporulation
REQ_RS10785	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
REQ_RS10790	COG0126	phosphoglycerate kinase activity
REQ_RS10795	COG0149	triose-phosphate isomerase activity
REQ_RS10800	COG2365	Tyrosine phosphatase family
REQ_RS10805	COG2365	Tyrosine phosphatase family
REQ_RS10820	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
REQ_RS10855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
REQ_RS10865	COG0109	protoheme IX farnesyltransferase activity
REQ_RS10895	COG1131	(ABC) transporter
REQ_RS10920	COG0396	ATPase activity
REQ_RS10930	COG0822	iron-sulfur transferase activity
REQ_RS10935	COG2151	metal-sulfur cluster biosynthetic enzyme
REQ_RS10940	COG4762	Protein conserved in bacteria
REQ_RS10945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
REQ_RS10950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
REQ_RS10960	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS10965	COG0488	(ABC) transporter
REQ_RS10985	COG1309	transcriptional regulator
REQ_RS10990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
REQ_RS11000	COG0791	NLP P60 protein
REQ_RS11000	COG3883	PFAM NLP P60 protein
REQ_RS11005	COG0714	Associated with various cellular activities
REQ_RS11015	COG2304	oxidoreductase activity
REQ_RS11030	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
REQ_RS11140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
REQ_RS11145	COG2318	DinB family
REQ_RS11155	COG3268	Saccharopine dehydrogenase
REQ_RS11175	COG1404	Belongs to the peptidase S8 family
REQ_RS11185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
REQ_RS11205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
REQ_RS11210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
REQ_RS11225	COG0667	Aldo Keto reductase
REQ_RS11230	COG1968	undecaprenyl-diphosphatase activity
REQ_RS11255	COG2409	Drug exporters of the RND superfamily
REQ_RS11260	COG0215	cysteine-tRNA ligase activity
REQ_RS11265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
REQ_RS11270	COG0590	tRNA wobble adenosine to inosine editing
REQ_RS11275	COG3224	Antibiotic biosynthesis monooxygenase
REQ_RS11320	COG0646	methionine synthase
REQ_RS11320	COG1410	methionine synthase
REQ_RS11325	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
REQ_RS11330	COG1054	Belongs to the UPF0176 family
REQ_RS11335	COG0564	pseudouridine synthase activity
REQ_RS11380	COG0789	Transcriptional regulator
REQ_RS11405	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
REQ_RS11420	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
REQ_RS11430	COG2378	regulation of single-species biofilm formation
REQ_RS11435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
REQ_RS11480	COG0300	oxidoreductase activity
REQ_RS11500	COG4221	oxidoreductase activity
REQ_RS11565	COG1716	ATPase activity
REQ_RS11565	COG0842	Transport permease protein
REQ_RS11565	COG1131	(ABC) transporter
REQ_RS11600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS11605	COG3012	SEC-C Motif Domain Protein
REQ_RS11675	COG0287	Prephenate dehydrogenase
REQ_RS11680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
REQ_RS11680	COG0512	Glutamine amidotransferase of anthranilate synthase
REQ_RS11685	COG1605	Chorismate mutase
REQ_RS11755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
REQ_RS11765	COG4974	Belongs to the 'phage' integrase family
REQ_RS11775	COG1252	NADH dehydrogenase
REQ_RS11790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
REQ_RS11795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
REQ_RS11800	COG1120	ATPase activity
REQ_RS11805	COG2015	COG2015, Alkyl sulfatase and related hydrolases
REQ_RS11810	COG1660	Displays ATPase and GTPase activities
REQ_RS11835	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
REQ_RS11840	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
REQ_RS11855	COG0513	Belongs to the DEAD box helicase family
REQ_RS11860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
REQ_RS11870	COG0513	Belongs to the DEAD box helicase family
REQ_RS11890	COG1253	flavin adenine dinucleotide binding
REQ_RS11895	COG1253	flavin adenine dinucleotide binding
REQ_RS11920	COG0346	lactoylglutathione lyase activity
REQ_RS11925	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
REQ_RS11935	COG1408	metallophosphoesterase
REQ_RS11940	COG2197	response regulator
REQ_RS11950	COG2226	methyltransferase
REQ_RS11975	COG1716	ATPase activity
REQ_RS12035	COG1160	GTP binding
REQ_RS12050	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
REQ_RS12070	COG0494	nUDIX hydrolase
REQ_RS12075	COG0504	CTP synthase activity
REQ_RS12110	COG0647	UMP catabolic process
REQ_RS12140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
REQ_RS12145	COG2094	Belongs to the DNA glycosylase MPG family
REQ_RS12150	COG1131	(ABC) transporter
REQ_RS12155	COG0842	Transport permease protein
REQ_RS12160	COG1309	transcriptional regulator
REQ_RS12165	COG2835	tetraacyldisaccharide 4'-kinase activity
REQ_RS12175	COG0165	Argininosuccinate lyase
REQ_RS12180	COG0137	argininosuccinate synthase activity
REQ_RS12185	COG1438	arginine binding
REQ_RS12195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
REQ_RS12200	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
REQ_RS12205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
REQ_RS12225	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
REQ_RS12225	COG0072	phenylalanine-tRNA ligase activity
REQ_RS12230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
REQ_RS12265	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
REQ_RS12285	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS12320	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
REQ_RS12320	COG0237	dephospho-CoA kinase activity
REQ_RS12330	COG0539	negative regulation of cytoplasmic translation
REQ_RS12335	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
REQ_RS12350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
REQ_RS12355	COG0473	3-isopropylmalate dehydrogenase activity
REQ_RS12365	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
REQ_RS12395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
REQ_RS12400	COG1335	isochorismatase
REQ_RS12405	COG1652	LysM domain
REQ_RS12415	COG1946	Acyl-CoA thioesterase
REQ_RS12430	COG0070	glutamate synthase
REQ_RS12430	COG0069	glutamate synthase activity
REQ_RS12430	COG0067	glutamate synthase
REQ_RS12440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
REQ_RS12445	COG0159	tryptophan synthase activity
REQ_RS12475	COG3384	dioxygenase
REQ_RS12500	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS12570	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS12575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
REQ_RS12575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
REQ_RS12580	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
REQ_RS12595	COG1309	transcriptional regulator
REQ_RS12600	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS12615	COG2814	Major facilitator Superfamily
REQ_RS12625	COG0667	Aldo Keto reductase
REQ_RS12630	COG1733	regulation of RNA biosynthetic process
REQ_RS12685	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
REQ_RS12695	COG0596	Alpha beta hydrolase
REQ_RS12760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
REQ_RS12765	COG2192	nodulation
REQ_RS12770	COG0546	phosphoglycolate phosphatase activity
REQ_RS12805	COG1058	Belongs to the CinA family
REQ_RS12805	COG1546	Belongs to the CinA family
REQ_RS12825	COG2890	protein-(glutamine-N5) methyltransferase activity
REQ_RS12885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS12890	COG3546	catalase activity
REQ_RS12900	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS12920	COG0723	plastoquinol--plastocyanin reductase activity
REQ_RS12920	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
REQ_RS12925	COG1982	Orn Lys Arg decarboxylase major
REQ_RS12955	COG1309	transcriptional regulator
REQ_RS12960	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
REQ_RS12970	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS13075	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
REQ_RS13080	COG0107	imidazoleglycerol-phosphate synthase activity
REQ_RS13085	COG0483	inositol monophosphate 1-phosphatase activity
REQ_RS13090	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
REQ_RS13100	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
REQ_RS13115	COG0131	Imidazoleglycerol-phosphate dehydratase
REQ_RS13120	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
REQ_RS13125	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
REQ_RS13135	COG2723	6-phospho-beta-galactosidase activity
REQ_RS13140	COG1280	lysine exporter protein (LysE YggA)
REQ_RS13200	COG2249	NAD(P)H dehydrogenase (quinone) activity
REQ_RS13215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
REQ_RS13250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
REQ_RS13300	COG1053	succinate dehydrogenase
REQ_RS13325	COG3634	alkyl hydroperoxide reductase activity
REQ_RS13335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
REQ_RS13340	COG0156	8-amino-7-oxononanoate synthase activity
REQ_RS13345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
REQ_RS13350	COG2755	lipolytic protein G-D-S-L family
REQ_RS13350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
REQ_RS13355	COG2124	cytochrome p450
REQ_RS13425	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS13445	COG3764	Sortase (surface protein transpeptidase)
REQ_RS13460	COG0477	Major facilitator Superfamily
REQ_RS13475	COG0028	Belongs to the TPP enzyme family
REQ_RS13525	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
REQ_RS13550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
REQ_RS13560	COG3599	regulation of cell shape
REQ_RS13575	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
REQ_RS13585	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
REQ_RS13590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
REQ_RS13595	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
REQ_RS13610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
REQ_RS13630	COG0768	penicillin binding
REQ_RS13645	COG2001	Belongs to the MraZ family
REQ_RS13690	COG0142	geranyltranstransferase activity
REQ_RS13720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
REQ_RS13730	COG5650	phosphatidylinositol metabolic process
REQ_RS13755	COG1940	carbohydrate kinase activity
REQ_RS13765	COG0003	Pfam Anion-transporting ATPase
REQ_RS13800	COG0791	NLP P60 protein
REQ_RS13815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
REQ_RS13825	COG1845	cytochrome c oxidase, subunit III
REQ_RS13855	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
REQ_RS13865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
REQ_RS13890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
REQ_RS13895	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
REQ_RS13900	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
REQ_RS13905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
REQ_RS13910	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
REQ_RS13930	COG0321	lipoyl(octanoyl) transferase activity
REQ_RS13935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
REQ_RS13950	COG0174	glutamine synthetase
REQ_RS13955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
REQ_RS13975	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
REQ_RS13985	COG2186	Transcriptional regulator
REQ_RS13990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
REQ_RS13995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
REQ_RS14000	COG1120	ATPase activity
REQ_RS14020	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
REQ_RS14025	COG0174	glutamine synthetase
REQ_RS14035	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
REQ_RS14070	COG1823	symporter activity
REQ_RS14120	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
REQ_RS14130	COG3766	membrane
REQ_RS14175	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
REQ_RS14190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
REQ_RS14255	COG0232	Belongs to the dGTPase family. Type 2 subfamily
REQ_RS14270	COG0423	glycine-tRNA ligase activity
REQ_RS14315	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
REQ_RS14320	COG1381	Involved in DNA repair and RecF pathway recombination
REQ_RS14365	COG0477	Major facilitator Superfamily
REQ_RS14380	COG0484	heat shock protein binding
REQ_RS14445	COG3842	ATPase activity
REQ_RS14450	COG4208	sulfate ABC transporter
REQ_RS14475	COG3387	PFAM Glycoside hydrolase 15-related
REQ_RS14485	COG2070	2-Nitropropane dioxygenase
REQ_RS14490	COG0481	GTPase activity
REQ_RS14500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
REQ_RS14505	COG0268	Binds directly to 16S ribosomal RNA
REQ_RS14515	COG0658	competence protein
REQ_RS14515	COG2333	competence protein COMEC
REQ_RS14530	COG2755	lipolytic protein G-D-S-L family
REQ_RS14535	COG0406	alpha-ribazole phosphatase activity
REQ_RS14540	COG0799	negative regulation of ribosome biogenesis
REQ_RS14545	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
REQ_RS14555	COG0542	response to heat
REQ_RS14560	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
REQ_RS14565	COG1113	amino acid transport
REQ_RS14570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
REQ_RS14575	COG1247	-acetyltransferase
REQ_RS14580	COG0514	ATP-dependent DNA helicase (RecQ)
REQ_RS14585	COG0456	acetyltransferase
REQ_RS14590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
REQ_RS14595	COG1917	Cupin 2, conserved barrel domain protein
REQ_RS14620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
REQ_RS14625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
REQ_RS14635	COG1530	ribonuclease E activity
REQ_RS14635	COG1530	ribonuclease E activity
REQ_RS14650	COG0285	dihydrofolate synthase activity
REQ_RS14655	COG0525	valine-tRNA ligase activity
REQ_RS14665	COG1506	peptidase
REQ_RS14665	COG0823	Involved in the tonB-independent uptake of proteins
REQ_RS14665	COG4946	Tricorn protease homolog
REQ_RS14675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
REQ_RS14685	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
REQ_RS14710	COG0740	serine-type endopeptidase activity
REQ_RS14715	COG0740	serine-type endopeptidase activity
REQ_RS14720	COG0544	peptidyl-prolyl cis-trans isomerase activity
REQ_RS14735	COG2070	2-Nitropropane dioxygenase
REQ_RS14740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
REQ_RS14760	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
REQ_RS14775	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
REQ_RS14795	COG0366	Alpha amylase catalytic
REQ_RS14815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
REQ_RS14840	COG2030	dehydratase
REQ_RS14855	COG2902	Dehydrogenase
REQ_RS14875	COG0629	single-stranded DNA binding
REQ_RS14880	COG3336	cytochrome c oxidase
REQ_RS14895	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
REQ_RS14950	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
REQ_RS14970	COG1309	transcriptional regulator
REQ_RS14975	COG0596	Alpha beta hydrolase
REQ_RS14990	COG2270	Major facilitator Superfamily
REQ_RS15010	COG0446	pyridine nucleotide-disulphide oxidoreductase
REQ_RS15010	COG1902	pentaerythritol trinitrate reductase activity
REQ_RS15015	COG0300	oxidoreductase activity
REQ_RS15030	COG0433	COG0433 Predicted ATPase
REQ_RS15035	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
REQ_RS15050	COG1376	ErfK ybiS ycfS ynhG family protein
REQ_RS15085	COG1309	transcriptional regulator
REQ_RS15105	COG0736	holo-[acyl-carrier-protein] synthase activity
REQ_RS15130	COG0706	membrane insertase activity
REQ_RS15155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
REQ_RS15175	COG0386	Belongs to the glutathione peroxidase family
REQ_RS15185	COG1254	Belongs to the acylphosphatase family
REQ_RS15205	COG1115	amino acid carrier protein
REQ_RS15220	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
REQ_RS15225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
REQ_RS15230	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
REQ_RS15240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
REQ_RS15245	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
REQ_RS15250	COG0571	ribonuclease III activity
REQ_RS15265	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
REQ_RS15270	COG0742	ribosomal rna small subunit methyltransferase
REQ_RS15275	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
REQ_RS15280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
REQ_RS15285	COG1461	Dihydroxyacetone kinase
REQ_RS15290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
REQ_RS15295	COG1024	Enoyl-CoA hydratase
REQ_RS15305	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
REQ_RS15335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
REQ_RS15345	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
REQ_RS15350	COG0406	alpha-ribazole phosphatase activity
REQ_RS15350	COG0494	nUDIX hydrolase
REQ_RS15355	COG0776	regulation of translation
REQ_RS15360	COG0066	3-isopropylmalate dehydratase activity
REQ_RS15365	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
REQ_RS15370	COG1414	Transcriptional regulator
REQ_RS15395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
REQ_RS15400	COG0179	Fumarylacetoacetate (FAA) hydrolase
REQ_RS15405	COG2271	Major facilitator Superfamily
REQ_RS15410	COG0473	3-isopropylmalate dehydrogenase activity
REQ_RS15420	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
REQ_RS15440	COG0129	dihydroxy-acid dehydratase activity
REQ_RS15460	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
REQ_RS15465	COG0205	6-phosphofructokinase activity
REQ_RS15470	COG2197	response regulator
REQ_RS15475	COG4585	Histidine kinase
REQ_RS15495	COG0154	amidase activity
REQ_RS15500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
REQ_RS15530	COG0482	sulfurtransferase activity
REQ_RS15550	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
REQ_RS15560	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
REQ_RS15575	COG0110	maltose O-acetyltransferase activity
REQ_RS15585	COG0686	Belongs to the AlaDH PNT family
REQ_RS15600	COG2226	methyltransferase
REQ_RS15615	COG1119	ATPase activity
REQ_RS15630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
REQ_RS15685	COG0431	NADPH-dependent FMN reductase
REQ_RS15690	COG1309	transcriptional regulator
REQ_RS15735	COG2233	PERMEase
REQ_RS15745	COG3608	succinylglutamate desuccinylase aspartoacylase
REQ_RS15745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
REQ_RS15750	COG0154	amidase activity
REQ_RS15785	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
REQ_RS15795	COG0521	Mo-molybdopterin cofactor biosynthetic process
REQ_RS15795	COG0315	cyclic pyranopterin monophosphate synthase activity
REQ_RS15800	COG0314	molybdopterin synthase activity
REQ_RS15805	COG0513	Belongs to the DEAD box helicase family
REQ_RS15810	COG0778	Nitroreductase
REQ_RS15830	COG2329	Antibiotic biosynthesis monooxygenase
REQ_RS15865	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
REQ_RS15870	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
REQ_RS15885	COG2267	carboxylic ester hydrolase activity
REQ_RS15900	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
REQ_RS15905	COG2177	Part of the ABC transporter FtsEX involved in
REQ_RS15910	COG2884	Cell division ATP-binding protein ftsE
REQ_RS15920	COG0668	transmembrane transport
REQ_RS15930	COG0483	inositol monophosphate 1-phosphatase activity
REQ_RS15950	COG0745	RESPONSE REGULATOR receiver
REQ_RS15955	COG1960	acyl-CoA dehydrogenase activity
REQ_RS15960	COG1960	acyl-CoA dehydrogenase activity
REQ_RS15980	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS15990	COG1388	LysM domain
REQ_RS15995	COG1615	UPF0182 protein
REQ_RS16005	COG3480	Lon protease (S16) C-terminal proteolytic domain
REQ_RS16025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
REQ_RS16065	COG1074	ATP-dependent DNA helicase activity
REQ_RS16070	COG0596	Alpha beta hydrolase
REQ_RS16090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
REQ_RS16090	COG5479	isomerase activity
REQ_RS16095	COG1162	GTPase activity
REQ_RS16110	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
REQ_RS16135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
REQ_RS16135	COG2146	nitrite reductase [NAD(P)H] activity
REQ_RS16140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
REQ_RS16145	COG0243	molybdopterin cofactor binding
REQ_RS16155	COG2807	transmembrane transport
REQ_RS16160	COG2186	Transcriptional regulator
REQ_RS16200	COG0513	Belongs to the DEAD box helicase family
REQ_RS16210	COG1192	Involved in chromosome partitioning
REQ_RS16215	COG0406	alpha-ribazole phosphatase activity
REQ_RS16230	COG1597	lipid kinase activity
REQ_RS16245	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
REQ_RS16265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS16275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
REQ_RS16280	COG1162	GTPase activity
REQ_RS16320	COG1011	Hydrolase
REQ_RS16335	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
REQ_RS16350	COG5002	protein histidine kinase activity
REQ_RS16355	COG0745	RESPONSE REGULATOR receiver
REQ_RS16365	COG1228	amidohydrolase
REQ_RS16370	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
REQ_RS16390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
REQ_RS16395	COG0531	amino acid
REQ_RS16400	COG1482	cell wall glycoprotein biosynthetic process
REQ_RS16430	COG0391	Required for morphogenesis under gluconeogenic growth conditions
REQ_RS16435	COG0778	Nitroreductase
REQ_RS16435	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
REQ_RS16455	COG3485	protocatechuate 3,4-dioxygenase
REQ_RS16460	COG3485	protocatechuate 3,4-dioxygenase
REQ_RS16470	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
REQ_RS16475	COG1414	Transcriptional regulator
REQ_RS16495	COG1414	Transcriptional regulator
REQ_RS16505	COG2755	lipolytic protein G-D-S-L family
REQ_RS16510	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
REQ_RS16525	COG1316	TRANSCRIPTIONal
REQ_RS16535	COG4591	ABC-type transport system involved in lipoprotein release permease component
REQ_RS16540	COG1136	(ABC) transporter
REQ_RS16545	COG2197	response regulator
REQ_RS16550	COG4585	Histidine kinase
REQ_RS16570	COG5002	protein histidine kinase activity
REQ_RS16575	COG0745	RESPONSE REGULATOR receiver
REQ_RS16600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
REQ_RS16635	COG4770	biotin carboxylase activity
REQ_RS16660	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
REQ_RS16660	COG2146	nitrite reductase [NAD(P)H] activity
REQ_RS16675	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS16680	COG0300	oxidoreductase activity
REQ_RS16685	COG2072	flavoprotein involved in K transport
REQ_RS16705	COG1201	RNA secondary structure unwinding
REQ_RS16710	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
REQ_RS16730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
REQ_RS16735	COG2161	toxin-antitoxin pair type II binding
REQ_RS16740	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
REQ_RS16755	COG1473	amidohydrolase
REQ_RS16755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
REQ_RS16775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
REQ_RS16790	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
REQ_RS16800	COG0791	NLP P60 protein
REQ_RS16825	COG2009	succinate dehydrogenase
REQ_RS16835	COG1053	succinate dehydrogenase
REQ_RS16840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
REQ_RS16845	COG1686	Belongs to the peptidase S11 family
REQ_RS16850	COG1295	ribonuclease BN
REQ_RS16855	COG0180	Tryptophanyl-tRNA synthetase
REQ_RS16870	COG0708	Exodeoxyribonuclease III
REQ_RS16875	COG2814	Major facilitator Superfamily
REQ_RS16890	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
REQ_RS16900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
REQ_RS16955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
REQ_RS16965	COG2855	membrane
REQ_RS16990	COG1937	Protein conserved in bacteria
REQ_RS16995	COG2409	Drug exporters of the RND superfamily
REQ_RS17005	COG0446	pyridine nucleotide-disulphide oxidoreductase
REQ_RS17010	COG0587	DNA-directed DNA polymerase activity
REQ_RS17035	COG4221	oxidoreductase activity
REQ_RS17065	COG2217	Heavy metal translocating P-type atpase
REQ_RS17080	COG0515	serine threonine protein kinase
REQ_RS17080	COG2815	serine threonine protein kinase
REQ_RS17090	COG4585	Histidine kinase
REQ_RS17095	COG1983	PspC domain protein
REQ_RS17105	COG0519	Catalyzes the synthesis of GMP from XMP
REQ_RS17105	COG0518	GMP synthase (glutamine-hydrolyzing) activity
REQ_RS17115	COG0516	GMP reductase activity
REQ_RS17165	COG0459	protein refolding
REQ_RS17170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
REQ_RS17180	COG0604	alcohol dehydrogenase
REQ_RS17190	COG2146	nitrite reductase [NAD(P)H] activity
REQ_RS17205	COG2267	carboxylic ester hydrolase activity
REQ_RS17215	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS17225	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
REQ_RS17250	COG0596	Alpha beta hydrolase
REQ_RS17250	COG0508	dehydrogenase complex catalyzes the overall conversion of
REQ_RS17255	COG3384	dioxygenase
REQ_RS17260	COG1414	Transcriptional regulator
REQ_RS17285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
REQ_RS17290	COG0456	acetyltransferase
REQ_RS17310	COG2267	carboxylic ester hydrolase activity
REQ_RS17315	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
REQ_RS17335	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
REQ_RS17370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
REQ_RS17390	COG1674	ftsk spoiiie
REQ_RS17400	COG1404	Belongs to the peptidase S8 family
REQ_RS17405	COG3266	domain, Protein
REQ_RS17415	COG0431	NADPH-dependent FMN reductase
REQ_RS17425	COG1960	acyl-CoA dehydrogenase activity
REQ_RS17430	COG0101	tRNA pseudouridine synthase activity
REQ_RS17435	COG0203	ribosomal protein L17
REQ_RS17440	COG0202	RNA polymerase activity
REQ_RS17460	COG0257	Belongs to the bacterial ribosomal protein bL36 family
REQ_RS17465	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
REQ_RS17480	COG0563	adenylate kinase activity
REQ_RS17505	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
REQ_RS17510	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
REQ_RS17525	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
REQ_RS17530	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
REQ_RS17535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
REQ_RS17565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
REQ_RS17570	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
REQ_RS17580	COG0088	Forms part of the polypeptide exit tunnel
REQ_RS17590	COG0051	transcription antitermination factor activity, RNA binding
REQ_RS17600	COG1802	Transcriptional regulator
REQ_RS17650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
REQ_RS17660	COG2030	dehydratase
REQ_RS17665	COG1960	acyl-CoA dehydrogenase activity
REQ_RS17675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
REQ_RS17695	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS17700	COG3284	Transcriptional regulator
REQ_RS17705	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS17710	COG0477	Major facilitator Superfamily
REQ_RS17770	COG0446	pyridine nucleotide-disulphide oxidoreductase
REQ_RS17770	COG1902	pentaerythritol trinitrate reductase activity
REQ_RS17795	COG0535	radical SAM domain protein
REQ_RS17830	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
REQ_RS17835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
REQ_RS17840	COG1302	Protein conserved in bacteria
REQ_RS17875	COG0583	DNA-binding transcription factor activity
REQ_RS17880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
REQ_RS17890	COG0049	tRNA binding
REQ_RS17895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
REQ_RS17910	COG1309	transcriptional regulator
REQ_RS17920	COG1024	Enoyl-CoA hydratase
REQ_RS17935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
REQ_RS17940	COG1960	acyl-CoA dehydrogenase activity
REQ_RS17960	COG0477	Major facilitator Superfamily
REQ_RS17970	COG3321	synthase
REQ_RS17970	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS17970	COG0604	alcohol dehydrogenase
REQ_RS18015	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
REQ_RS18040	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
REQ_RS18045	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
REQ_RS18065	COG0081	regulation of translation
REQ_RS18080	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
REQ_RS18090	COG2030	dehydratase
REQ_RS18095	COG2030	dehydratase
REQ_RS18100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
REQ_RS18125	COG1666	GTP binding
REQ_RS18130	COG0501	Belongs to the peptidase M48B family
REQ_RS18135	COG0142	geranyltranstransferase activity
REQ_RS18145	COG2226	methyltransferase
REQ_RS18150	COG0671	phosphoesterase, PA-phosphatase related
REQ_RS18160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
REQ_RS18165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
REQ_RS18180	COG4948	Mandelate Racemase Muconate Lactonizing
REQ_RS18195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
REQ_RS18195	COG2755	lipolytic protein G-D-S-L family
REQ_RS18205	COG0514	ATP-dependent DNA helicase (RecQ)
REQ_RS18300	COG1950	PFAM Membrane protein of
REQ_RS18340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
REQ_RS18370	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
REQ_RS18375	COG1333	cytochrome c biogenesis protein
REQ_RS18380	COG0785	Cytochrome C biogenesis protein
REQ_RS18390	COG0406	alpha-ribazole phosphatase activity
REQ_RS18395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
REQ_RS18405	COG2890	protein-(glutamine-N5) methyltransferase activity
REQ_RS18410	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
REQ_RS18415	COG2133	pyrroloquinoline quinone binding
REQ_RS18435	COG2608	mercury ion transmembrane transporter activity
REQ_RS18440	COG1937	Protein conserved in bacteria
REQ_RS18475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
REQ_RS18475	COG1587	Uroporphyrinogen-III synthase
REQ_RS18480	COG0181	hydroxymethylbilane synthase activity
REQ_RS18485	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
REQ_RS18490	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
REQ_RS18565	COG0745	RESPONSE REGULATOR receiver
REQ_RS18570	COG5002	protein histidine kinase activity
REQ_RS18575	COG0588	phosphoglycerate mutase activity
REQ_RS18585	COG1388	LysM domain
REQ_RS18595	COG0438	transferase activity, transferring glycosyl groups
REQ_RS18610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
REQ_RS18680	COG0812	UDP-N-acetylmuramate dehydrogenase activity
REQ_RS18715	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
REQ_RS18725	COG0788	formyltetrahydrofolate deformylase activity
REQ_RS18730	COG0596	Alpha beta hydrolase
REQ_RS18735	COG0789	Transcriptional regulator
REQ_RS18760	COG2733	membrane
REQ_RS18775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
REQ_RS18780	COG2326	polyphosphate kinase activity
REQ_RS18800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
REQ_RS18810	COG2224	Isocitrate lyase
REQ_RS18855	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS18865	COG1137	ATPase activity
REQ_RS18875	COG1172	Belongs to the binding-protein-dependent transport system permease family
REQ_RS18900	COG2357	RelA SpoT domain protein
REQ_RS18910	COG0702	epimerase
REQ_RS18915	COG1733	regulation of RNA biosynthetic process
REQ_RS18935	COG1522	sequence-specific DNA binding
REQ_RS18940	COG1505	serine-type exopeptidase activity
REQ_RS18970	COG0647	UMP catabolic process
REQ_RS18980	COG0688	phosphatidylethanolamine metabolic process
REQ_RS18995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
REQ_RS19020	COG0494	nUDIX hydrolase
REQ_RS19025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
REQ_RS19025	COG2111	Na H antiporter
REQ_RS19030	COG1006	Multisubunit Na H antiporter MnhC subunit
REQ_RS19035	COG0651	ATP synthesis coupled electron transport
REQ_RS19060	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
REQ_RS19120	COG0351	phosphomethylpyrimidine kinase
REQ_RS19135	COG2234	aminopeptidase activity
REQ_RS19155	COG1131	(ABC) transporter
REQ_RS19165	COG2022	thiamine diphosphate biosynthetic process
REQ_RS19180	COG0352	thiamine-phosphate diphosphorylase activity
REQ_RS19190	COG1051	belongs to the nudix hydrolase family
REQ_RS19225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
REQ_RS19230	COG0515	serine threonine protein kinase
REQ_RS19240	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
REQ_RS19245	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
REQ_RS19265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS19305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
REQ_RS19330	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
REQ_RS19340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
REQ_RS19350	COG1804	L-carnitine dehydratase bile acid-inducible protein F
REQ_RS19365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
REQ_RS19375	COG2197	response regulator
REQ_RS19395	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
REQ_RS19400	COG2218	PFAM glutamate synthase alpha subunit domain protein
REQ_RS19405	COG0069	glutamate synthase activity
REQ_RS19450	COG1994	Peptidase M50
REQ_RS19460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
REQ_RS19475	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS19485	COG4129	membrane
REQ_RS19510	COG0586	Pfam SNARE associated Golgi protein
REQ_RS19530	COG0300	oxidoreductase activity
REQ_RS19560	COG1846	Transcriptional regulator
REQ_RS19565	COG2814	Major facilitator Superfamily
REQ_RS19580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
REQ_RS19615	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
REQ_RS19620	COG2072	flavoprotein involved in K transport
REQ_RS19630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
REQ_RS19635	COG0542	response to heat
REQ_RS19670	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS19675	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS19680	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS19685	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS19700	COG0346	lactoylglutathione lyase activity
REQ_RS19705	COG1414	Transcriptional regulator
REQ_RS19720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS19735	COG1137	ATPase activity
REQ_RS19755	COG0789	Transcriptional regulator
REQ_RS19760	COG0484	heat shock protein binding
REQ_RS19765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
REQ_RS19770	COG0443	Heat shock 70 kDa protein
REQ_RS19795	COG0583	DNA-binding transcription factor activity
REQ_RS19820	COG0443	Heat shock 70 kDa protein
REQ_RS19845	COG2181	nitrate reductase activity
REQ_RS19845	COG0247	lactate metabolic process
REQ_RS19855	COG4946	Tricorn protease homolog
REQ_RS19855	COG1506	peptidase
REQ_RS19855	COG0823	Involved in the tonB-independent uptake of proteins
REQ_RS19910	COG1216	Glycosyl transferase, family 2
REQ_RS19915	COG2244	polysaccharide biosynthetic process
REQ_RS19925	COG0438	transferase activity, transferring glycosyl groups
REQ_RS19935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
REQ_RS19995	COG1116	anion transmembrane transporter activity
REQ_RS20000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
REQ_RS20005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
REQ_RS20025	COG0667	Aldo Keto reductase
REQ_RS20050	COG1960	acyl-CoA dehydrogenase activity
REQ_RS20060	COG4133	protoheme IX ABC transporter activity
REQ_RS20075	COG0183	Belongs to the thiolase family
REQ_RS20080	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS20085	COG2030	dehydratase
REQ_RS20090	COG0789	Transcriptional regulator
REQ_RS20105	COG1309	transcriptional regulator
REQ_RS20110	COG1472	Belongs to the glycosyl hydrolase 3 family
REQ_RS20115	COG0589	response to stress
REQ_RS20125	COG4981	capsule polysaccharide biosynthetic process
REQ_RS20150	COG0438	transferase activity, transferring glycosyl groups
REQ_RS20175	COG0531	amino acid
REQ_RS20190	COG1045	serine acetyltransferase
REQ_RS20200	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
REQ_RS20220	COG0220	tRNA (guanine-N7-)-methyltransferase activity
REQ_RS20255	COG1802	Transcriptional regulator
REQ_RS20260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
REQ_RS20270	COG2353	YceI-like domain
REQ_RS20275	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
REQ_RS20290	COG3104	oligopeptide transport
REQ_RS20310	COG1960	acyl-CoA dehydrogenase activity
REQ_RS20315	COG0501	Belongs to the peptidase M48B family
REQ_RS20320	COG1309	transcriptional regulator
REQ_RS20345	COG0488	(ABC) transporter
REQ_RS20370	COG1122	ATPase activity
REQ_RS20400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
REQ_RS20410	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
REQ_RS20445	COG0316	Belongs to the HesB IscA family
REQ_RS20445	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
REQ_RS20455	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
REQ_RS20460	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
REQ_RS20465	COG0375	protein maturation
REQ_RS20475	COG2175	clavaminate synthase activity
REQ_RS20480	COG0747	negative chemotaxis
REQ_RS20485	COG0640	Transcriptional regulator
REQ_RS20490	COG2267	carboxylic ester hydrolase activity
REQ_RS20505	COG2902	Dehydrogenase
REQ_RS20510	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
REQ_RS20535	COG2986	histidine ammonia-lyase
REQ_RS20540	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
REQ_RS20545	COG0277	FAD linked oxidase domain protein
REQ_RS20550	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
REQ_RS20555	COG1228	amidohydrolase
REQ_RS20560	COG0010	Belongs to the arginase family
REQ_RS20575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
REQ_RS20580	COG4569	acetaldehyde dehydrogenase (acetylating) activity
REQ_RS20585	COG3971	2-oxopent-4-enoate hydratase activity
REQ_RS20590	COG1414	Transcriptional regulator
REQ_RS20600	COG1473	amidohydrolase
REQ_RS20605	COG1960	acyl-CoA dehydrogenase activity
REQ_RS20615	COG1846	Transcriptional regulator
REQ_RS20635	COG4941	Belongs to the sigma-70 factor family
REQ_RS20640	COG3795	YCII-related domain
REQ_RS20645	COG2267	carboxylic ester hydrolase activity
REQ_RS20650	COG2267	carboxylic ester hydrolase activity
REQ_RS20680	COG2267	carboxylic ester hydrolase activity
REQ_RS20695	COG1802	Transcriptional regulator
REQ_RS20705	COG0235	Class ii aldolase
REQ_RS20715	COG1309	transcriptional regulator
REQ_RS20725	COG0477	Major facilitator Superfamily
REQ_RS20730	COG2197	response regulator
REQ_RS20760	COG3590	peptidase
REQ_RS20770	COG1742	UPF0060 membrane protein
REQ_RS20775	COG1376	ErfK ybiS ycfS ynhG family protein
REQ_RS20785	COG3360	Dodecin
REQ_RS20790	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
REQ_RS20800	COG1793	dna ligase
REQ_RS20810	COG0598	Magnesium transport protein CorA
REQ_RS20835	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS20845	COG1960	acyl-CoA dehydrogenase activity
REQ_RS20850	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS20865	COG0183	Belongs to the thiolase family
REQ_RS20935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
REQ_RS20945	COG0477	Major facilitator Superfamily
REQ_RS20960	COG0444	Belongs to the ABC transporter superfamily
REQ_RS20965	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
REQ_RS20970	COG0601	transmembrane transport
REQ_RS21005	COG1309	transcriptional regulator
REQ_RS21010	COG2072	flavoprotein involved in K transport
REQ_RS21015	COG0590	tRNA wobble adenosine to inosine editing
REQ_RS21030	COG0583	DNA-binding transcription factor activity
REQ_RS21035	COG0129	dihydroxy-acid dehydratase activity
REQ_RS21040	COG0477	Major facilitator Superfamily
REQ_RS21045	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS21060	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
REQ_RS21070	COG0477	Major facilitator Superfamily
REQ_RS21080	COG0444	Belongs to the ABC transporter superfamily
REQ_RS21090	COG0601	transmembrane transport
REQ_RS21100	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS21105	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS21110	COG0183	Belongs to the thiolase family
REQ_RS21155	COG1024	Enoyl-CoA hydratase
REQ_RS21165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
REQ_RS21180	COG1414	Transcriptional regulator
REQ_RS21195	COG0492	ferredoxin-NADP+ reductase activity
REQ_RS21210	COG1116	anion transmembrane transporter activity
REQ_RS21210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
REQ_RS21220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
REQ_RS21225	COG0508	dehydrogenase complex catalyzes the overall conversion of
REQ_RS21225	COG0596	Alpha beta hydrolase
REQ_RS21260	COG2814	Major facilitator Superfamily
REQ_RS21270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
REQ_RS21275	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS21285	COG2030	dehydratase
REQ_RS21290	COG0183	Belongs to the thiolase family
REQ_RS21300	COG1960	acyl-CoA dehydrogenase activity
REQ_RS21310	COG1960	acyl-CoA dehydrogenase activity
REQ_RS21320	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS21325	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS21335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS21350	COG0668	transmembrane transport
REQ_RS21360	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS21370	COG2030	dehydratase
REQ_RS21380	COG1960	acyl-CoA dehydrogenase activity
REQ_RS21385	COG0183	Belongs to the thiolase family
REQ_RS21390	COG1309	transcriptional regulator
REQ_RS21395	COG1960	acyl-CoA dehydrogenase activity
REQ_RS21435	COG0346	lactoylglutathione lyase activity
REQ_RS21445	COG1053	succinate dehydrogenase
REQ_RS21455	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
REQ_RS21465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS21550	COG1063	alcohol dehydrogenase
REQ_RS21580	COG1012	belongs to the aldehyde dehydrogenase family
REQ_RS21590	COG1309	transcriptional regulator
REQ_RS21605	COG1902	pentaerythritol trinitrate reductase activity
REQ_RS21605	COG0446	pyridine nucleotide-disulphide oxidoreductase
REQ_RS21625	COG2072	flavoprotein involved in K transport
REQ_RS21695	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
REQ_RS21705	COG1053	succinate dehydrogenase
REQ_RS21715	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS21735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
REQ_RS21740	COG0477	Major facilitator Superfamily
REQ_RS21745	COG0583	DNA-binding transcription factor activity
REQ_RS21760	COG2354	Protein conserved in bacteria
REQ_RS21770	COG1253	flavin adenine dinucleotide binding
REQ_RS21780	COG2409	Drug exporters of the RND superfamily
REQ_RS21800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
REQ_RS21820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
REQ_RS21820	COG2169	Transcriptional regulator
REQ_RS21865	COG3185	4-Hydroxyphenylpyruvate dioxygenase
REQ_RS21870	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS21895	COG0657	acetylesterase activity
REQ_RS21920	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
REQ_RS21950	COG0702	epimerase
REQ_RS21975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS21990	COG3794	PFAM blue (type 1) copper domain protein
REQ_RS21995	COG2132	Multicopper oxidase
REQ_RS22010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
REQ_RS22035	COG1174	glycine betaine transport
REQ_RS22045	COG1174	glycine betaine transport
REQ_RS22065	COG1309	transcriptional regulator
REQ_RS22075	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS22095	COG1316	TRANSCRIPTIONal
REQ_RS22120	COG0745	RESPONSE REGULATOR receiver
REQ_RS22125	COG2205	protein histidine kinase activity
REQ_RS22140	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS22145	COG2072	flavoprotein involved in K transport
REQ_RS22150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
REQ_RS22155	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS22170	COG2197	response regulator
REQ_RS22175	COG0477	Major facilitator Superfamily
REQ_RS22180	COG0829	nickel cation binding
REQ_RS22185	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
REQ_RS22190	COG0830	nickel cation binding
REQ_RS22195	COG0804	urea catabolic process
REQ_RS22205	COG0831	urea catabolic process
REQ_RS22215	COG0601	transmembrane transport
REQ_RS22220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
REQ_RS22230	COG4608	Belongs to the ABC transporter superfamily
REQ_RS22255	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
REQ_RS22260	COG1522	sequence-specific DNA binding
REQ_RS22265	COG3265	gluconokinase activity
REQ_RS22275	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS22290	COG2124	cytochrome p450
REQ_RS22315	COG0463	Glycosyl transferase, family 2
REQ_RS22330	COG0583	DNA-binding transcription factor activity
REQ_RS22335	COG0477	Major facilitator Superfamily
REQ_RS22340	COG1309	transcriptional regulator
REQ_RS22350	COG0318	PFAM AMP-dependent synthetase and ligase
REQ_RS22390	COG1902	pentaerythritol trinitrate reductase activity
REQ_RS22390	COG0446	pyridine nucleotide-disulphide oxidoreductase
REQ_RS22395	COG2271	Major facilitator Superfamily
REQ_RS22405	COG2301	Belongs to the HpcH HpaI aldolase family
REQ_RS22415	COG0390	transport system, permease component
REQ_RS22445	COG1024	Enoyl-CoA hydratase
REQ_RS22460	COG4303	Ethanolamine ammonia lyase large subunit
REQ_RS22480	COG2072	flavoprotein involved in K transport
REQ_RS22510	COG4941	Belongs to the sigma-70 factor family
REQ_RS22570	COG1959	2 iron, 2 sulfur cluster binding
REQ_RS22575	COG1309	transcriptional regulator
REQ_RS22655	COG0359	binds to the 23S rRNA
REQ_RS22660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
REQ_RS22690	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
REQ_RS22720	COG1695	Transcriptional regulator
REQ_RS22725	COG1260	myo-inositol-1-phosphate synthase
REQ_RS22730	COG0488	(ABC) transporter
REQ_RS22745	COG1960	acyl-CoA dehydrogenase activity
REQ_RS22760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
REQ_RS22765	COG1725	Transcriptional regulator
REQ_RS22770	COG1131	(ABC) transporter
REQ_RS22780	COG0477	Major facilitator Superfamily
REQ_RS22785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
REQ_RS22810	COG3842	ATPase activity
REQ_RS22825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
REQ_RS22830	COG0765	amino acid transport
REQ_RS22835	COG1126	abc transporter atp-binding protein
REQ_RS22875	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
REQ_RS22880	COG1796	DNA polymerase
REQ_RS22880	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
REQ_RS22885	COG1764	response to oxidative stress
REQ_RS22890	COG1846	Transcriptional regulator
REQ_RS22905	COG0300	oxidoreductase activity
REQ_RS22915	COG3631	Ketosteroid isomerase-related protein
REQ_RS22945	COG0495	leucyl-tRNA aminoacylation
REQ_RS22960	COG0583	DNA-binding transcription factor activity
REQ_RS22970	COG0076	glutamate decarboxylase activity
REQ_RS22980	COG1678	Uncharacterized ACR, COG1678
REQ_RS23040	COG0617	tRNA 3'-terminal CCA addition
REQ_RS23060	COG1595	DNA-templated transcription, initiation
REQ_RS23070	COG1309	transcriptional regulator
REQ_RS23080	COG0577	efflux transmembrane transporter activity
REQ_RS23080	COG1136	(ABC) transporter
REQ_RS23085	COG1309	transcriptional regulator
REQ_RS23095	COG0492	ferredoxin-NADP+ reductase activity
REQ_RS23095	COG3118	belongs to the thioredoxin family
REQ_RS23100	COG3409	Peptidoglycan-binding domain 1 protein
REQ_RS23100	COG0860	N-Acetylmuramoyl-L-alanine amidase
REQ_RS23115	COG1192	Involved in chromosome partitioning
REQ_RS23120	COG0357	Ribosomal RNA small subunit methyltransferase G
REQ_RS23130	COG0706	membrane insertase activity
REQ_RS23135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
REQ_RS23210	COG1388	LysM domain
REQ_RS23255	COG1053	succinate dehydrogenase
REQ_RS23300	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS23330	COG2030	dehydratase
REQ_RS23385	COG0583	DNA-binding transcription factor activity
REQ_RS23455	COG0667	Aldo Keto reductase
REQ_RS23470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
REQ_RS23515	COG0789	Transcriptional regulator
REQ_RS23560	COG0230	Belongs to the bacterial ribosomal protein bL34 family
REQ_RS23620	COG1028	Short-chain dehydrogenase reductase Sdr
REQ_RS23625	COG1028	Short-chain dehydrogenase reductase Sdr