locus-tag	class	description
HFP48_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HFP48_RS00010	COG0592	DNA-directed DNA polymerase activity
HFP48_RS00020	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
HFP48_RS00040	COG0187	DNA topoisomerase II activity
HFP48_RS00050	COG2018	Roadblock/LC7 domain
HFP48_RS00075	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFP48_RS00100	COG0693	protein deglycase activity
HFP48_RS00105	COG1309	transcriptional regulator
HFP48_RS00130	COG2837	iron assimilation
HFP48_RS00135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFP48_RS00180	COG0705	Rhomboid family
HFP48_RS00180	COG0457	Tetratricopeptide repeat
HFP48_RS00205	COG0515	serine threonine protein kinase
HFP48_RS00205	COG2815	serine threonine protein kinase
HFP48_RS00210	COG0515	serine threonine protein kinase
HFP48_RS00215	COG0768	penicillin binding
HFP48_RS00230	COG1716	ATPase activity
HFP48_RS00235	COG1716	ATPase activity
HFP48_RS00260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS00270	COG0069	glutamate synthase activity
HFP48_RS00270	COG0067	glutamate synthase
HFP48_RS00270	COG0070	glutamate synthase
HFP48_RS00295	COG0789	Transcriptional regulator
HFP48_RS00310	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HFP48_RS00330	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HFP48_RS00330	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFP48_RS00345	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HFP48_RS00355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HFP48_RS00375	COG1609	Transcriptional regulator
HFP48_RS00380	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS00385	COG1063	alcohol dehydrogenase
HFP48_RS00390	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS00405	COG1609	Transcriptional regulator
HFP48_RS00420	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFP48_RS00445	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS00465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS00475	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS00520	COG2409	Drug exporters of the RND superfamily
HFP48_RS00560	COG0702	epimerase
HFP48_RS00570	COG0415	Belongs to the DNA photolyase family
HFP48_RS00575	COG2501	S4 domain
HFP48_RS00590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFP48_RS00655	COG0183	Belongs to the thiolase family
HFP48_RS00660	COG2030	dehydratase
HFP48_RS00660	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS00670	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS00675	COG1024	Enoyl-CoA hydratase
HFP48_RS00680	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS00685	COG0183	Belongs to the thiolase family
HFP48_RS00695	COG1309	transcriptional regulator
HFP48_RS00705	COG1396	sequence-specific DNA binding
HFP48_RS00755	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFP48_RS00765	COG3706	GGDEF domain
HFP48_RS00780	COG2072	flavoprotein involved in K transport
HFP48_RS00810	COG4770	biotin carboxylase activity
HFP48_RS00880	COG2508	Transcriptional regulator
HFP48_RS00890	COG2814	Major facilitator Superfamily
HFP48_RS00900	COG2119	membrane
HFP48_RS00910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HFP48_RS00920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFP48_RS00955	COG1316	TRANSCRIPTIONal
HFP48_RS00970	COG0628	permease
HFP48_RS01030	COG1024	Enoyl-CoA hydratase
HFP48_RS01035	COG3321	synthase
HFP48_RS01035	COG0604	alcohol dehydrogenase
HFP48_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS01045	COG0183	Belongs to the thiolase family
HFP48_RS01065	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS01105	COG1024	Enoyl-CoA hydratase
HFP48_RS01170	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFP48_RS01180	COG0121	glutamine amidotransferase
HFP48_RS01205	COG1597	lipid kinase activity
HFP48_RS01210	COG0477	Major facilitator Superfamily
HFP48_RS01215	COG0121	glutamine amidotransferase
HFP48_RS01245	COG1937	Protein conserved in bacteria
HFP48_RS01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS01260	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HFP48_RS01290	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HFP48_RS01300	COG1309	transcriptional regulator
HFP48_RS01315	COG0659	secondary active sulfate transmembrane transporter activity
HFP48_RS01320	COG0789	Transcriptional regulator
HFP48_RS01330	COG0477	Major facilitator Superfamily
HFP48_RS01365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS01395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HFP48_RS01420	COG2146	nitrite reductase [NAD(P)H] activity
HFP48_RS01420	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFP48_RS01425	COG0204	Acyl-transferase
HFP48_RS01430	COG0561	phosphatase activity
HFP48_RS01440	COG2385	sporulation resulting in formation of a cellular spore
HFP48_RS01445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS01475	COG1733	regulation of RNA biosynthetic process
HFP48_RS01480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFP48_RS01495	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS01505	COG0789	Transcriptional regulator
HFP48_RS01515	COG1216	Glycosyl transferase, family 2
HFP48_RS01525	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HFP48_RS01530	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HFP48_RS01540	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HFP48_RS01540	COG5479	isomerase activity
HFP48_RS01560	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS01570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFP48_RS01605	COG0247	lactate metabolic process
HFP48_RS01605	COG0277	FAD linked oxidase domain protein
HFP48_RS01620	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS01625	COG0277	FAD linked oxidase domain protein
HFP48_RS01640	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HFP48_RS01645	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HFP48_RS01650	COG1088	dTDP-glucose 4,6-dehydratase activity
HFP48_RS01660	COG0463	Glycosyl transferase, family 2
HFP48_RS01665	COG1215	transferase activity, transferring glycosyl groups
HFP48_RS01675	COG1216	Glycosyl transferase, family 2
HFP48_RS01690	COG1216	Glycosyl transferase, family 2
HFP48_RS01715	COG1063	alcohol dehydrogenase
HFP48_RS01735	COG5479	isomerase activity
HFP48_RS01735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HFP48_RS01745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFP48_RS01765	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP48_RS01765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS01770	COG0730	response to heat
HFP48_RS01780	COG0270	DNA (cytosine-5-)-methyltransferase activity
HFP48_RS01820	COG0154	amidase activity
HFP48_RS01825	COG0287	Prephenate dehydrogenase
HFP48_RS01835	COG0590	tRNA wobble adenosine to inosine editing
HFP48_RS01870	COG2409	Drug exporters of the RND superfamily
HFP48_RS01890	COG1472	Belongs to the glycosyl hydrolase 3 family
HFP48_RS01905	COG2072	flavoprotein involved in K transport
HFP48_RS01930	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS01950	COG2814	Major facilitator Superfamily
HFP48_RS01955	COG0343	queuine tRNA-ribosyltransferase activity
HFP48_RS01965	COG5473	translation initiation factor activity
HFP48_RS01975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFP48_RS01980	COG0583	DNA-binding transcription factor activity
HFP48_RS01990	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS01995	COG3226	Transcriptional regulator
HFP48_RS02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS02085	COG0477	Major facilitator Superfamily
HFP48_RS02115	COG0596	Alpha beta hydrolase
HFP48_RS02140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HFP48_RS02165	COG1024	Enoyl-CoA hydratase
HFP48_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02185	COG2030	dehydratase
HFP48_RS02195	COG1946	Acyl-CoA thioesterase
HFP48_RS02200	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02215	COG1024	Enoyl-CoA hydratase
HFP48_RS02220	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS02250	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02265	COG2271	Major facilitator Superfamily
HFP48_RS02280	COG0183	Belongs to the thiolase family
HFP48_RS02290	COG0300	oxidoreductase activity
HFP48_RS02300	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS02320	COG0583	DNA-binding transcription factor activity
HFP48_RS02325	COG0583	DNA-binding transcription factor activity
HFP48_RS02330	COG0791	NLP P60 protein
HFP48_RS02335	COG0657	acetylesterase activity
HFP48_RS02385	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02415	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS02460	COG0405	Gamma-glutamyltransferase
HFP48_RS02465	COG2146	nitrite reductase [NAD(P)H] activity
HFP48_RS02470	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS02505	COG3069	C4-dicarboxylate transmembrane transporter activity
HFP48_RS02520	COG2197	response regulator
HFP48_RS02525	COG0183	Belongs to the thiolase family
HFP48_RS02530	COG1024	Enoyl-CoA hydratase
HFP48_RS02530	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP48_RS02540	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFP48_RS02555	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFP48_RS02560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HFP48_RS02565	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HFP48_RS02570	COG1309	transcriptional regulator
HFP48_RS02590	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS02610	COG1309	transcriptional regulator
HFP48_RS02620	COG1024	Enoyl-CoA hydratase
HFP48_RS02635	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP48_RS02645	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFP48_RS02700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFP48_RS02720	COG1024	Enoyl-CoA hydratase
HFP48_RS02730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFP48_RS02765	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HFP48_RS02770	COG1522	sequence-specific DNA binding
HFP48_RS02775	COG0778	Nitroreductase
HFP48_RS02780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP48_RS02785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS02790	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFP48_RS02810	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS02810	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS02850	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02890	COG0471	metal ion transport
HFP48_RS02890	COG3273	potassium ion transport
HFP48_RS02915	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS02995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP48_RS02995	COG1877	trehalose-phosphatase activity
HFP48_RS03000	COG0640	Transcriptional regulator
HFP48_RS03005	COG0375	protein maturation
HFP48_RS03010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HFP48_RS03020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HFP48_RS03055	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HFP48_RS03075	COG0298	carbon dioxide binding
HFP48_RS03090	COG1122	ATPase activity
HFP48_RS03105	COG0310	cobalt ion transport
HFP48_RS03125	COG0384	phenazine biosynthesis protein PhzF
HFP48_RS03130	COG0477	Major facilitator Superfamily
HFP48_RS03135	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS03140	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS03215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFP48_RS03240	COG1408	metallophosphoesterase
HFP48_RS03280	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS03315	COG2267	carboxylic ester hydrolase activity
HFP48_RS03325	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFP48_RS03330	COG0477	Major facilitator Superfamily
HFP48_RS03335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP48_RS03385	COG1111	helicase
HFP48_RS03385	COG1205	dead DEAH box helicase
HFP48_RS03390	COG1278	Cold shock
HFP48_RS03400	COG1754	DNA topoisomerase type I activity
HFP48_RS03400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HFP48_RS03415	COG0470	DNA polymerase III
HFP48_RS03490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFP48_RS03495	COG0442	prolyl-tRNA aminoacylation
HFP48_RS03520	COG2027	D-alanyl-D-alanine carboxypeptidase
HFP48_RS03530	COG0037	tRNA processing
HFP48_RS03540	COG2815	serine threonine protein kinase
HFP48_RS03540	COG0515	serine threonine protein kinase
HFP48_RS03545	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFP48_RS03550	COG0302	gtp cyclohydrolase
HFP48_RS03555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFP48_RS03560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HFP48_RS03585	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HFP48_RS03590	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HFP48_RS03595	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HFP48_RS03605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HFP48_RS03615	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HFP48_RS03640	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS03660	COG4762	Protein conserved in bacteria
HFP48_RS03680	COG0288	reversible hydration of carbon dioxide
HFP48_RS03690	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HFP48_RS03700	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HFP48_RS03705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HFP48_RS03715	COG1329	Transcriptional regulator
HFP48_RS03720	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HFP48_RS03725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HFP48_RS03730	COG0215	cysteine-tRNA ligase activity
HFP48_RS03735	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HFP48_RS03745	COG1984	allophanate hydrolase subunit 2
HFP48_RS03765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFP48_RS03770	COG1121	(ABC) transporter
HFP48_RS03775	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFP48_RS03780	COG1609	Transcriptional regulator
HFP48_RS03785	COG3387	PFAM Glycoside hydrolase 15-related
HFP48_RS03790	COG1309	transcriptional regulator
HFP48_RS03795	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS03800	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS03805	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS03810	COG2030	dehydratase
HFP48_RS03830	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS03850	COG0471	metal ion transport
HFP48_RS03880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS03880	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HFP48_RS03920	COG1793	dna ligase
HFP48_RS03920	COG3285	dna ligase
HFP48_RS03925	COG0477	Major facilitator Superfamily
HFP48_RS03930	COG1414	Transcriptional regulator
HFP48_RS03940	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HFP48_RS03955	COG2030	dehydratase
HFP48_RS03960	COG1053	succinate dehydrogenase
HFP48_RS03965	COG3971	2-oxopent-4-enoate hydratase activity
HFP48_RS03970	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HFP48_RS03975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFP48_RS03990	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFP48_RS03995	COG2197	response regulator
HFP48_RS04000	COG4585	Histidine kinase
HFP48_RS04015	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HFP48_RS04055	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04060	COG2267	carboxylic ester hydrolase activity
HFP48_RS04065	COG0346	lactoylglutathione lyase activity
HFP48_RS04070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS04090	COG0656	L-ascorbic acid biosynthetic process
HFP48_RS04095	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04100	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04105	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04110	COG1024	Enoyl-CoA hydratase
HFP48_RS04115	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS04120	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04130	COG1309	transcriptional regulator
HFP48_RS04135	COG0183	Belongs to the thiolase family
HFP48_RS04165	COG2072	flavoprotein involved in K transport
HFP48_RS04170	COG2272	Belongs to the type-B carboxylesterase lipase family
HFP48_RS04175	COG0702	epimerase
HFP48_RS04195	COG1024	Enoyl-CoA hydratase
HFP48_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS04205	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HFP48_RS04215	COG0183	Belongs to the thiolase family
HFP48_RS04220	COG2124	cytochrome p450
HFP48_RS04225	COG1053	succinate dehydrogenase
HFP48_RS04265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS04285	COG2070	2-Nitropropane dioxygenase
HFP48_RS04295	COG0789	Transcriptional regulator
HFP48_RS04305	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS04310	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04315	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04325	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS04335	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP48_RS04360	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HFP48_RS04380	COG0784	Response regulator, receiver
HFP48_RS04385	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HFP48_RS04400	COG1132	(ABC) transporter
HFP48_RS04415	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS04425	COG0477	Major facilitator Superfamily
HFP48_RS04430	COG3959	Transketolase, thiamine diphosphate binding domain
HFP48_RS04435	COG3958	Transketolase
HFP48_RS04450	COG0673	inositol 2-dehydrogenase activity
HFP48_RS04460	COG3962	Belongs to the TPP enzyme family
HFP48_RS04465	COG3718	enzyme involved in inositol metabolism
HFP48_RS04475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP48_RS04480	COG2188	Transcriptional regulator
HFP48_RS04485	COG0183	Belongs to the thiolase family
HFP48_RS04520	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04525	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS04530	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS04535	COG1946	Acyl-CoA thioesterase
HFP48_RS04560	COG2130	NADP-dependent
HFP48_RS04590	COG0582	viral genome integration into host DNA
HFP48_RS04920	COG3795	YCII-related domain
HFP48_RS04925	COG4941	Belongs to the sigma-70 factor family
HFP48_RS04950	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS04975	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS05020	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS05035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS05040	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS05065	COG2030	dehydratase
HFP48_RS05065	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS05070	COG0183	Belongs to the thiolase family
HFP48_RS05080	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS05085	COG0183	Belongs to the thiolase family
HFP48_RS05090	COG1024	Enoyl-CoA hydratase
HFP48_RS05100	COG1309	transcriptional regulator
HFP48_RS05125	COG0515	serine threonine protein kinase
HFP48_RS05125	COG2815	serine threonine protein kinase
HFP48_RS05160	COG0745	RESPONSE REGULATOR receiver
HFP48_RS05165	COG2205	protein histidine kinase activity
HFP48_RS05190	COG0436	Aminotransferase
HFP48_RS05200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HFP48_RS05230	COG0477	Major facilitator Superfamily
HFP48_RS05235	COG1846	Transcriptional regulator
HFP48_RS05255	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFP48_RS05265	COG2072	flavoprotein involved in K transport
HFP48_RS05275	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS05285	COG3290	protein histidine kinase activity
HFP48_RS05305	COG0589	response to stress
HFP48_RS05330	COG1132	(ABC) transporter
HFP48_RS05335	COG3433	isochorismatase activity
HFP48_RS05335	COG1535	isochorismatase
HFP48_RS05340	COG1021	2,3-dihydroxybenzoate-AMP ligase
HFP48_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS05355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFP48_RS05360	COG1522	sequence-specific DNA binding
HFP48_RS05385	COG1535	isochorismatase
HFP48_RS05385	COG3433	isochorismatase activity
HFP48_RS05400	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS05425	COG2226	methyltransferase
HFP48_RS05435	COG0640	Transcriptional regulator
HFP48_RS05470	COG2357	RelA SpoT domain protein
HFP48_RS05475	COG2375	cellular response to nickel ion
HFP48_RS05480	COG0477	Major facilitator Superfamily
HFP48_RS05485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HFP48_RS05495	COG4565	transcriptional regulatory protein
HFP48_RS05500	COG3290	protein histidine kinase activity
HFP48_RS05505	COG1301	dicarboxylic acid transport
HFP48_RS05520	COG0583	DNA-binding transcription factor activity
HFP48_RS05525	COG3634	alkyl hydroperoxide reductase activity
HFP48_RS05535	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS05570	COG0697	spore germination
HFP48_RS05595	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS05600	COG0477	Major facilitator Superfamily
HFP48_RS05610	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS05620	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS05650	COG2197	response regulator
HFP48_RS05660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS05680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS05685	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HFP48_RS05730	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HFP48_RS05745	COG2132	Multicopper oxidase
HFP48_RS05765	COG0386	Belongs to the glutathione peroxidase family
HFP48_RS05770	COG0778	Nitroreductase
HFP48_RS05825	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFP48_RS05830	COG0047	phosphoribosylformylglycinamidine synthase activity
HFP48_RS05835	COG2205	protein histidine kinase activity
HFP48_RS05840	COG0745	RESPONSE REGULATOR receiver
HFP48_RS05860	COG2217	Heavy metal translocating P-type atpase
HFP48_RS05875	COG1362	aminopeptidase activity
HFP48_RS05885	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HFP48_RS05910	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HFP48_RS05940	COG1271	oxidase subunit
HFP48_RS05945	COG1294	oxidase, subunit
HFP48_RS05950	COG4988	ABC transporter
HFP48_RS05955	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HFP48_RS05960	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HFP48_RS05975	COG2897	thiosulfate sulfurtransferase activity
HFP48_RS05995	COG0745	RESPONSE REGULATOR receiver
HFP48_RS06015	COG0581	inorganic phosphate transmembrane transporter activity
HFP48_RS06020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HFP48_RS06090	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS06100	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS06105	COG2226	methyltransferase
HFP48_RS06155	COG1024	Enoyl-CoA hydratase
HFP48_RS06165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS06175	COG2814	Major facilitator Superfamily
HFP48_RS06180	COG0243	molybdopterin cofactor binding
HFP48_RS06185	COG3383	formate dehydrogenase (NAD+) activity
HFP48_RS06195	COG0493	'glutamate synthase
HFP48_RS06195	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFP48_RS06205	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS06210	COG0477	Major facilitator Superfamily
HFP48_RS06215	COG0243	molybdopterin cofactor binding
HFP48_RS06230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS06260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS06280	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS06320	COG2814	Major facilitator Superfamily
HFP48_RS06330	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS06345	COG2124	cytochrome p450
HFP48_RS06350	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS06355	COG4638	Rieske (2fe-2S)
HFP48_RS06360	COG0454	-acetyltransferase
HFP48_RS06360	COG0456	acetyltransferase
HFP48_RS06385	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS06395	COG2814	Major facilitator Superfamily
HFP48_RS06405	COG1024	Enoyl-CoA hydratase
HFP48_RS06420	COG2124	cytochrome p450
HFP48_RS06435	COG4221	oxidoreductase activity
HFP48_RS06465	COG1053	succinate dehydrogenase
HFP48_RS06465	COG3976	FMN-binding domain protein
HFP48_RS06475	COG1309	transcriptional regulator
HFP48_RS06490	COG0733	neurotransmitter:sodium symporter activity
HFP48_RS06520	COG0589	response to stress
HFP48_RS06550	COG0564	pseudouridine synthase activity
HFP48_RS06585	COG1953	Uracil, thiamine, allantoin
HFP48_RS06605	COG0569	domain protein
HFP48_RS06610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HFP48_RS06630	COG1764	response to oxidative stress
HFP48_RS06635	COG1846	Transcriptional regulator
HFP48_RS06640	COG0542	response to heat
HFP48_RS06655	COG1755	Isoprenylcysteine carboxyl methyltransferase
HFP48_RS06660	COG0492	ferredoxin-NADP+ reductase activity
HFP48_RS06675	COG0366	Alpha amylase catalytic
HFP48_RS06680	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HFP48_RS06685	COG1216	Glycosyl transferase, family 2
HFP48_RS06690	COG5285	phytanoyl-CoA dioxygenase
HFP48_RS06695	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HFP48_RS06730	COG1595	DNA-templated transcription, initiation
HFP48_RS06750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS06785	COG2851	Citrate transporter
HFP48_RS06790	COG3290	protein histidine kinase activity
HFP48_RS06795	COG4565	transcriptional regulatory protein
HFP48_RS06815	COG1652	LysM domain
HFP48_RS06830	COG1278	Cold shock
HFP48_RS06840	COG2814	Major facilitator Superfamily
HFP48_RS06860	COG0671	phosphoesterase, PA-phosphatase related
HFP48_RS06870	COG2252	PERMEase
HFP48_RS06875	COG1846	Transcriptional regulator
HFP48_RS06910	COG0259	pyridoxamine-phosphate oxidase activity
HFP48_RS06915	COG0477	Major facilitator Superfamily
HFP48_RS06930	COG0583	DNA-binding transcription factor activity
HFP48_RS06940	COG2017	converts alpha-aldose to the beta-anomer
HFP48_RS06950	COG0545	Peptidyl-prolyl cis-trans isomerase
HFP48_RS06960	COG2205	protein histidine kinase activity
HFP48_RS06970	COG1309	transcriptional regulator
HFP48_RS06975	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS06995	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS07010	COG1295	ribonuclease BN
HFP48_RS07030	COG1668	transmembrane transport
HFP48_RS07035	COG4152	abc transporter atp-binding protein
HFP48_RS07055	COG0488	(ABC) transporter
HFP48_RS07060	COG0656	L-ascorbic acid biosynthetic process
HFP48_RS07070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFP48_RS07075	COG2072	flavoprotein involved in K transport
HFP48_RS07110	COG0583	DNA-binding transcription factor activity
HFP48_RS07120	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS07150	COG1024	Enoyl-CoA hydratase
HFP48_RS07165	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS07175	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS07180	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HFP48_RS07190	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP48_RS07195	COG2814	Major facilitator Superfamily
HFP48_RS07200	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS07205	COG0025	NhaP-type Na H and K H
HFP48_RS07210	COG1966	Carbon starvation protein
HFP48_RS07225	COG3275	phosphorelay sensor kinase activity
HFP48_RS07230	COG3279	Response regulator of the LytR AlgR family
HFP48_RS07240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP48_RS07250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP48_RS07265	COG2020	methyltransferase activity
HFP48_RS07270	COG1742	UPF0060 membrane protein
HFP48_RS07300	COG1937	Protein conserved in bacteria
HFP48_RS07340	COG0739	heme binding
HFP48_RS07355	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP48_RS07355	COG1017	nitric oxide dioxygenase activity
HFP48_RS07360	COG1959	2 iron, 2 sulfur cluster binding
HFP48_RS07365	COG2239	Acts as a magnesium transporter
HFP48_RS07375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS07435	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFP48_RS07440	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HFP48_RS07455	COG2272	Belongs to the type-B carboxylesterase lipase family
HFP48_RS07465	COG1309	transcriptional regulator
HFP48_RS07470	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS07480	COG0166	Belongs to the GPI family
HFP48_RS07500	COG0739	heme binding
HFP48_RS07510	COG0045	succinate-CoA ligase (ADP-forming) activity
HFP48_RS07520	COG1739	Uncharacterized protein family UPF0029
HFP48_RS07560	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HFP48_RS07580	COG0679	Auxin Efflux Carrier
HFP48_RS07590	COG2188	Transcriptional regulator
HFP48_RS07605	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HFP48_RS07610	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HFP48_RS07615	COG3639	organic phosphonate transmembrane transporter activity
HFP48_RS07630	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFP48_RS07635	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFP48_RS07640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HFP48_RS07645	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFP48_RS07675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFP48_RS07680	COG0315	cyclic pyranopterin monophosphate synthase activity
HFP48_RS07680	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFP48_RS07695	COG1970	mechanosensitive ion channel activity
HFP48_RS07710	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HFP48_RS07715	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFP48_RS07725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP48_RS07735	COG2226	methyltransferase
HFP48_RS07760	COG1136	(ABC) transporter
HFP48_RS07775	COG2197	response regulator
HFP48_RS07780	COG4044	May play a role in the intracellular transport of hydrophobic ligands
HFP48_RS07800	COG1970	mechanosensitive ion channel activity
HFP48_RS07805	COG1725	Transcriptional regulator
HFP48_RS07810	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HFP48_RS07830	COG1115	amino acid carrier protein
HFP48_RS07835	COG4249	Peptidase C14 caspase catalytic subunit p20
HFP48_RS07835	COG2319	Wd-40 repeat
HFP48_RS07845	COG1595	DNA-templated transcription, initiation
HFP48_RS07865	COG0084	hydrolase, TatD family'
HFP48_RS07880	COG0346	lactoylglutathione lyase activity
HFP48_RS07885	COG2259	Doxx family
HFP48_RS07890	COG1126	abc transporter atp-binding protein
HFP48_RS07895	COG0765	amino acid transport
HFP48_RS07900	COG3583	domain protein
HFP48_RS07905	COG3583	domain protein
HFP48_RS07910	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HFP48_RS07915	COG1278	Cold shock
HFP48_RS07920	COG1278	Cold shock
HFP48_RS07930	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HFP48_RS07935	COG0488	(ABC) transporter
HFP48_RS07950	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS07955	COG1024	Enoyl-CoA hydratase
HFP48_RS07990	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HFP48_RS07995	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS08000	COG0193	aminoacyl-tRNA hydrolase activity
HFP48_RS08010	COG3976	FMN-binding domain protein
HFP48_RS08010	COG1053	succinate dehydrogenase
HFP48_RS08015	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HFP48_RS08025	COG3572	ergothioneine biosynthetic process
HFP48_RS08030	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HFP48_RS08035	COG0121	glutamine amidotransferase
HFP48_RS08040	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HFP48_RS08045	COG2814	Major facilitator Superfamily
HFP48_RS08050	COG0477	Major facilitator Superfamily
HFP48_RS08055	COG2226	methyltransferase
HFP48_RS08090	COG1309	transcriptional regulator
HFP48_RS08115	COG3956	TIGRFAM MazG family protein
HFP48_RS08130	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP48_RS08170	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS08190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HFP48_RS08205	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFP48_RS08240	COG2837	iron assimilation
HFP48_RS08250	COG0672	)-iron permease
HFP48_RS08260	COG0148	phosphopyruvate hydratase activity
HFP48_RS08360	COG2813	Specifically methylates the guanine in position
HFP48_RS08365	COG0670	Belongs to the BI1 family
HFP48_RS08370	COG2755	lipolytic protein G-D-S-L family
HFP48_RS08385	COG0791	NLP P60 protein
HFP48_RS08390	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HFP48_RS08400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFP48_RS08410	COG1331	Highly conserved protein containing a thioredoxin domain
HFP48_RS08415	COG0668	transmembrane transport
HFP48_RS08425	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFP48_RS08440	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HFP48_RS08445	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HFP48_RS08455	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
HFP48_RS08490	COG0477	Major facilitator Superfamily
HFP48_RS08495	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS08520	COG1722	exodeoxyribonuclease VII activity
HFP48_RS08525	COG1570	exodeoxyribonuclease VII activity
HFP48_RS08545	COG1322	Protein conserved in bacteria
HFP48_RS08555	COG0419	ATPase involved in DNA repair
HFP48_RS08570	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFP48_RS08575	COG0012	GTP binding
HFP48_RS08610	COG0277	FAD linked oxidase domain protein
HFP48_RS08630	COG0640	Transcriptional regulator
HFP48_RS08640	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HFP48_RS08645	COG1074	ATP-dependent DNA helicase activity
HFP48_RS08650	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HFP48_RS08660	COG3654	unkown
HFP48_RS08665	COG2072	flavoprotein involved in K transport
HFP48_RS08675	COG0390	transport system, permease component
HFP48_RS08680	COG0740	serine-type endopeptidase activity
HFP48_RS08685	COG0740	serine-type endopeptidase activity
HFP48_RS08690	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS08695	COG1396	sequence-specific DNA binding
HFP48_RS08710	COG1793	dna ligase
HFP48_RS08715	COG3842	ATPase activity
HFP48_RS08720	COG0395	ABC-type sugar transport system, permease component
HFP48_RS08725	COG1175	transmembrane transport
HFP48_RS08740	COG1063	alcohol dehydrogenase
HFP48_RS08745	COG0246	Mannitol dehydrogenase
HFP48_RS08755	COG1070	Carbohydrate kinase
HFP48_RS08770	COG0477	Major facilitator Superfamily
HFP48_RS08785	COG1414	Transcriptional regulator
HFP48_RS08790	COG3971	2-oxopent-4-enoate hydratase activity
HFP48_RS08800	COG1942	4-Oxalocrotonate Tautomerase
HFP48_RS08860	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HFP48_RS08870	COG1595	DNA-templated transcription, initiation
HFP48_RS08890	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HFP48_RS08890	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HFP48_RS08930	COG3757	hydrolase, family 25
HFP48_RS08935	COG2814	Major facilitator Superfamily
HFP48_RS08950	COG1051	belongs to the nudix hydrolase family
HFP48_RS08955	COG2154	pterin-4-alpha-carbinolamine dehydratase
HFP48_RS08975	COG0747	negative chemotaxis
HFP48_RS08980	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFP48_RS09015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HFP48_RS09035	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS09040	COG0506	proline dehydrogenase activity
HFP48_RS09065	COG1113	amino acid transport
HFP48_RS09070	COG2171	N-acyltransferase activity
HFP48_RS09075	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFP48_RS09080	COG1611	Belongs to the LOG family
HFP48_RS09085	COG1611	Belongs to the LOG family
HFP48_RS09090	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS09095	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HFP48_RS09100	COG0463	Glycosyl transferase, family 2
HFP48_RS09110	COG0519	Catalyzes the synthesis of GMP from XMP
HFP48_RS09125	COG0297	glycogen (starch) synthase activity
HFP48_RS09130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HFP48_RS09135	COG4122	O-methyltransferase activity
HFP48_RS09140	COG1595	DNA-templated transcription, initiation
HFP48_RS09145	COG5662	AntiSigma factor
HFP48_RS09150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HFP48_RS09180	COG2239	Acts as a magnesium transporter
HFP48_RS09185	COG2301	Belongs to the HpcH HpaI aldolase family
HFP48_RS09235	COG0514	ATP-dependent DNA helicase (RecQ)
HFP48_RS09255	COG0598	Magnesium transport protein CorA
HFP48_RS09260	COG0613	PHP domain protein
HFP48_RS09290	COG2072	flavoprotein involved in K transport
HFP48_RS09295	COG1309	transcriptional regulator
HFP48_RS09300	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP48_RS09300	COG0567	Dehydrogenase, E1 component
HFP48_RS09305	COG1132	(ABC) transporter
HFP48_RS09320	COG0596	Alpha beta hydrolase
HFP48_RS09340	COG0435	Glutathione S-transferase
HFP48_RS09360	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS09365	COG1024	Enoyl-CoA hydratase
HFP48_RS09370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
HFP48_RS09415	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HFP48_RS09440	COG2318	DinB family
HFP48_RS09445	COG1132	(ABC) transporter
HFP48_RS09450	COG3467	pyridoxamine 5'-phosphate
HFP48_RS09460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HFP48_RS09465	COG0577	efflux transmembrane transporter activity
HFP48_RS09465	COG1136	(ABC) transporter
HFP48_RS09470	COG0577	efflux transmembrane transporter activity
HFP48_RS09470	COG1136	(ABC) transporter
HFP48_RS09490	COG0596	Alpha beta hydrolase
HFP48_RS09500	COG2936	dipeptidyl-peptidase activity
HFP48_RS09510	COG1929	Belongs to the glycerate kinase type-1 family
HFP48_RS09515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HFP48_RS09520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS09535	COG3550	peptidyl-serine autophosphorylation
HFP48_RS09560	COG0583	DNA-binding transcription factor activity
HFP48_RS09565	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS09570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS09580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS09590	COG0477	Major facilitator Superfamily
HFP48_RS09600	COG0477	Major facilitator Superfamily
HFP48_RS09635	COG0519	Catalyzes the synthesis of GMP from XMP
HFP48_RS09635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFP48_RS09640	COG0579	oxidoreductase
HFP48_RS09645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS09650	COG2814	Major facilitator Superfamily
HFP48_RS09655	COG1414	Transcriptional regulator
HFP48_RS09665	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFP48_RS09680	COG1063	alcohol dehydrogenase
HFP48_RS09685	COG1335	isochorismatase
HFP48_RS09725	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS09735	COG2267	carboxylic ester hydrolase activity
HFP48_RS09745	COG0583	DNA-binding transcription factor activity
HFP48_RS09765	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFP48_RS09770	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS09775	COG0439	Biotin carboxylase
HFP48_RS09810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP48_RS09845	COG2313	pseudouridylate synthase activity
HFP48_RS09865	COG0505	Belongs to the CarA family
HFP48_RS09870	COG0492	ferredoxin-NADP+ reductase activity
HFP48_RS09895	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
HFP48_RS09915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS09940	COG1832	CoA-binding protein
HFP48_RS09950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HFP48_RS09955	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS09975	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS09980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS09985	COG1414	Transcriptional regulator
HFP48_RS09995	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFP48_RS09995	COG2508	Transcriptional regulator
HFP48_RS10010	COG0346	lactoylglutathione lyase activity
HFP48_RS10020	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
HFP48_RS10045	COG3971	2-oxopent-4-enoate hydratase activity
HFP48_RS10050	COG1414	Transcriptional regulator
HFP48_RS10085	COG2301	Belongs to the HpcH HpaI aldolase family
HFP48_RS10090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS10180	COG1100	Small GTP-binding protein
HFP48_RS10225	COG1609	Transcriptional regulator
HFP48_RS10230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS10240	COG0154	amidase activity
HFP48_RS10245	COG2814	Major facilitator Superfamily
HFP48_RS10250	COG1335	isochorismatase
HFP48_RS10265	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP48_RS10270	COG0431	NADPH-dependent FMN reductase
HFP48_RS10280	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS10280	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS10315	COG4552	Acetyltransferase involved in intracellular survival and related
HFP48_RS10335	COG2326	polyphosphate kinase activity
HFP48_RS10380	COG0183	Belongs to the thiolase family
HFP48_RS10400	COG1022	Amp-dependent synthetase and ligase
HFP48_RS10410	COG2197	response regulator
HFP48_RS10430	COG0657	acetylesterase activity
HFP48_RS10440	COG1116	anion transmembrane transporter activity
HFP48_RS10445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFP48_RS10450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFP48_RS10455	COG0351	phosphomethylpyrimidine kinase
HFP48_RS10455	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HFP48_RS10455	COG0352	thiamine-phosphate diphosphorylase activity
HFP48_RS10460	COG2272	Belongs to the type-B carboxylesterase lipase family
HFP48_RS10495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFP48_RS10535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HFP48_RS10545	COG3189	MarR family transcriptional regulator
HFP48_RS10550	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFP48_RS10575	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP48_RS10580	COG0022	dehydrogenase e1 component
HFP48_RS10595	COG0183	Belongs to the thiolase family
HFP48_RS10605	COG3135	benzoate transporter
HFP48_RS10615	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFP48_RS10630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HFP48_RS10650	COG1024	Enoyl-CoA hydratase
HFP48_RS10670	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFP48_RS10705	COG1218	3'(2'),5'-bisphosphate nucleotidase
HFP48_RS10730	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HFP48_RS10745	COG0018	arginyl-trna synthetase
HFP48_RS10750	COG0019	diaminopimelate decarboxylase activity
HFP48_RS10755	COG0460	homoserine dehydrogenase
HFP48_RS10760	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HFP48_RS10775	COG0254	rRNA binding
HFP48_RS10780	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HFP48_RS10790	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP48_RS10800	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HFP48_RS10810	COG0356	it plays a direct role in the translocation of protons across the membrane
HFP48_RS10815	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFP48_RS10820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HFP48_RS10825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HFP48_RS10830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HFP48_RS10835	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HFP48_RS10840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HFP48_RS10860	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HFP48_RS10885	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
HFP48_RS10900	COG0346	lactoylglutathione lyase activity
HFP48_RS10905	COG0183	Belongs to the thiolase family
HFP48_RS10910	COG2409	Drug exporters of the RND superfamily
HFP48_RS10925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HFP48_RS10930	COG0366	Alpha amylase catalytic
HFP48_RS10935	COG0058	SHG alpha-glucan phosphorylase activity
HFP48_RS10945	COG0596	Alpha beta hydrolase
HFP48_RS10985	COG1335	isochorismatase
HFP48_RS10990	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HFP48_RS10995	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HFP48_RS11020	COG1234	tRNA 3'-trailer cleavage
HFP48_RS11025	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HFP48_RS11030	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HFP48_RS11055	COG0736	holo-[acyl-carrier-protein] synthase activity
HFP48_RS11065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFP48_RS11085	COG1376	ErfK ybiS ycfS ynhG family protein
HFP48_RS11120	COG1376	ErfK ybiS ycfS ynhG family protein
HFP48_RS11135	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
HFP48_RS11140	COG0433	COG0433 Predicted ATPase
HFP48_RS11145	COG0300	oxidoreductase activity
HFP48_RS11150	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS11150	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS11180	COG0596	Alpha beta hydrolase
HFP48_RS11185	COG1309	transcriptional regulator
HFP48_RS11205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFP48_RS11215	COG1620	l-lactate permease
HFP48_RS11220	COG0277	FAD linked oxidase domain protein
HFP48_RS11305	COG3336	cytochrome c oxidase
HFP48_RS11340	COG2902	Dehydrogenase
HFP48_RS11345	COG0824	Thioesterase
HFP48_RS11360	COG0366	Alpha amylase catalytic
HFP48_RS11380	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HFP48_RS11395	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HFP48_RS11430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS11435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP48_RS11465	COG0544	peptidyl-prolyl cis-trans isomerase activity
HFP48_RS11470	COG0740	serine-type endopeptidase activity
HFP48_RS11475	COG0740	serine-type endopeptidase activity
HFP48_RS11485	COG0477	Major facilitator Superfamily
HFP48_RS11490	COG1309	transcriptional regulator
HFP48_RS11495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFP48_RS11510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFP48_RS11530	COG0069	glutamate synthase activity
HFP48_RS11535	COG2218	PFAM glutamate synthase alpha subunit domain protein
HFP48_RS11540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HFP48_RS11560	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP48_RS11585	COG0697	spore germination
HFP48_RS11625	COG0823	Involved in the tonB-independent uptake of proteins
HFP48_RS11625	COG4946	Tricorn protease homolog
HFP48_RS11625	COG1506	peptidase
HFP48_RS11635	COG0525	valine-tRNA ligase activity
HFP48_RS11640	COG0285	dihydrofolate synthase activity
HFP48_RS11655	COG1530	ribonuclease E activity
HFP48_RS11665	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HFP48_RS11670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HFP48_RS11685	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HFP48_RS11690	COG1917	Cupin 2, conserved barrel domain protein
HFP48_RS11695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFP48_RS11700	COG0456	acetyltransferase
HFP48_RS11705	COG0514	ATP-dependent DNA helicase (RecQ)
HFP48_RS11730	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HFP48_RS11735	COG1024	Enoyl-CoA hydratase
HFP48_RS11740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HFP48_RS11745	COG1461	Dihydroxyacetone kinase
HFP48_RS11750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HFP48_RS11755	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFP48_RS11760	COG0742	ribosomal rna small subunit methyltransferase
HFP48_RS11765	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HFP48_RS11780	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HFP48_RS11785	COG0571	ribonuclease III activity
HFP48_RS11790	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFP48_RS11800	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFP48_RS11830	COG1131	(ABC) transporter
HFP48_RS11845	COG1131	(ABC) transporter
HFP48_RS11850	COG1309	transcriptional regulator
HFP48_RS11860	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS11865	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS11870	COG0583	DNA-binding transcription factor activity
HFP48_RS11885	COG1254	Belongs to the acylphosphatase family
HFP48_RS11910	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HFP48_RS11930	COG0228	four-way junction DNA binding
HFP48_RS11940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HFP48_RS11945	COG0336	Belongs to the RNA methyltransferase TrmD family
HFP48_RS11970	COG0681	Belongs to the peptidase S26 family
HFP48_RS11985	COG0792	nuclease activity
HFP48_RS12010	COG2814	Major facilitator Superfamily
HFP48_RS12015	COG4974	Belongs to the 'phage' integrase family
HFP48_RS12035	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HFP48_RS12040	COG0528	UMP kinase activity
HFP48_RS12045	COG0233	cytoplasmic translational termination
HFP48_RS12050	COG0575	Belongs to the CDS family
HFP48_RS12060	COG2301	Belongs to the HpcH HpaI aldolase family
HFP48_RS12070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HFP48_RS12080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HFP48_RS12100	COG0768	penicillin binding
HFP48_RS12105	COG2197	response regulator
HFP48_RS12110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP48_RS12135	COG0579	oxidoreductase
HFP48_RS12140	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS12145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFP48_RS12145	COG1648	precorrin-2 dehydrogenase activity
HFP48_RS12160	COG3022	response to hydroperoxide
HFP48_RS12165	COG0442	prolyl-tRNA aminoacylation
HFP48_RS12170	COG4122	O-methyltransferase activity
HFP48_RS12200	COG0481	GTPase activity
HFP48_RS12200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HFP48_RS12210	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HFP48_RS12215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HFP48_RS12235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HFP48_RS12245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HFP48_RS12250	COG1121	(ABC) transporter
HFP48_RS12255	COG0803	Belongs to the bacterial solute-binding protein 9 family
HFP48_RS12270	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HFP48_RS12305	COG1140	nitrate reductase beta subunit
HFP48_RS12320	COG0612	Peptidase, M16
HFP48_RS12325	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HFP48_RS12350	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HFP48_RS12360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HFP48_RS12370	COG1674	ftsk spoiiie
HFP48_RS12385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HFP48_RS12395	COG1058	Belongs to the CinA family
HFP48_RS12395	COG1546	Belongs to the CinA family
HFP48_RS12400	COG1396	sequence-specific DNA binding
HFP48_RS12415	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HFP48_RS12420	COG1122	ATPase activity
HFP48_RS12425	COG1268	BioY protein
HFP48_RS12435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HFP48_RS12440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HFP48_RS12490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HFP48_RS12495	COG2137	regulation of response to DNA damage stimulus
HFP48_RS12500	COG0765	amino acid transport
HFP48_RS12505	COG0765	amino acid transport
HFP48_RS12510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP48_RS12515	COG1126	abc transporter atp-binding protein
HFP48_RS12520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HFP48_RS12530	COG1196	nuclear chromosome segregation
HFP48_RS12540	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HFP48_RS12550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HFP48_RS12565	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HFP48_RS12565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP48_RS12565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HFP48_RS12575	COG1349	DNA-binding transcription factor activity
HFP48_RS12580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HFP48_RS12585	COG2233	PERMEase
HFP48_RS12590	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS12610	COG1643	Atp-dependent helicase
HFP48_RS12615	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFP48_RS12655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFP48_RS12660	COG4581	dead DEAH box helicase
HFP48_RS12695	COG0123	including yeast histone deacetylase and acetoin utilization protein
HFP48_RS12700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HFP48_RS12700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HFP48_RS12710	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP48_RS12750	COG0475	glutathione-regulated potassium exporter activity
HFP48_RS12785	COG0756	dUTP diphosphatase activity
HFP48_RS12815	COG0569	domain protein
HFP48_RS12820	COG0531	amino acid
HFP48_RS12825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HFP48_RS12830	COG1846	Transcriptional regulator
HFP48_RS12835	COG0477	Major facilitator Superfamily
HFP48_RS12850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HFP48_RS12855	COG0477	Major facilitator Superfamily
HFP48_RS12860	COG1024	Enoyl-CoA hydratase
HFP48_RS12860	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP48_RS12865	COG0183	Belongs to the thiolase family
HFP48_RS12890	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HFP48_RS12905	COG0039	L-malate dehydrogenase activity
HFP48_RS12925	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HFP48_RS12990	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HFP48_RS13010	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS13015	COG1051	belongs to the nudix hydrolase family
HFP48_RS13020	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HFP48_RS13030	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HFP48_RS13040	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HFP48_RS13045	COG0632	four-way junction helicase activity
HFP48_RS13050	COG2255	four-way junction helicase activity
HFP48_RS13065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HFP48_RS13070	COG0747	negative chemotaxis
HFP48_RS13075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HFP48_RS13080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HFP48_RS13110	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HFP48_RS13125	COG0124	histidyl-tRNA synthetase
HFP48_RS13145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFP48_RS13160	COG0484	heat shock protein binding
HFP48_RS13165	COG1473	amidohydrolase
HFP48_RS13165	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS13175	COG0367	asparagine synthase
HFP48_RS13180	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS13180	COG2308	Evidence 4 Homologs of previously reported genes of
HFP48_RS13215	COG1984	allophanate hydrolase subunit 2
HFP48_RS13230	COG1113	amino acid transport
HFP48_RS13240	COG1366	Belongs to the anti-sigma-factor antagonist family
HFP48_RS13250	COG2208	phosphoserine phosphatase activity
HFP48_RS13255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HFP48_RS13255	COG4124	Belongs to the glycosyl hydrolase 26 family
HFP48_RS13260	COG2072	flavoprotein involved in K transport
HFP48_RS13290	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HFP48_RS13350	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HFP48_RS13395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HFP48_RS13400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HFP48_RS13410	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFP48_RS13430	COG4941	Belongs to the sigma-70 factor family
HFP48_RS13445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HFP48_RS13450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HFP48_RS13470	COG0640	Transcriptional regulator
HFP48_RS13495	COG0006	proline dipeptidase activity
HFP48_RS13500	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HFP48_RS13505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HFP48_RS13510	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HFP48_RS13515	COG0540	Belongs to the ATCase OTCase family
HFP48_RS13530	COG0505	Belongs to the CarA family
HFP48_RS13540	COG0284	orotidine-5'-phosphate decarboxylase activity
HFP48_RS13550	COG0194	GDP metabolic process
HFP48_RS13555	COG1758	RNA polymerase activity
HFP48_RS13565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HFP48_RS13620	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS13620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS13635	COG0322	excinuclease ABC activity
HFP48_RS13640	COG1660	Displays ATPase and GTPase activities
HFP48_RS13650	COG1481	regulation of sporulation
HFP48_RS13655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HFP48_RS13660	COG0126	phosphoglycerate kinase activity
HFP48_RS13665	COG0149	triose-phosphate isomerase activity
HFP48_RS13675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HFP48_RS13685	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HFP48_RS13720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HFP48_RS13730	COG0109	protoheme IX farnesyltransferase activity
HFP48_RS13755	COG1131	(ABC) transporter
HFP48_RS13780	COG0396	ATPase activity
HFP48_RS13805	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HFP48_RS13830	COG1309	transcriptional regulator
HFP48_RS13835	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HFP48_RS13845	COG0791	NLP P60 protein
HFP48_RS13845	COG3883	PFAM NLP P60 protein
HFP48_RS13850	COG0714	Associated with various cellular activities
HFP48_RS13860	COG2304	oxidoreductase activity
HFP48_RS13865	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS13930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS13935	COG0730	response to heat
HFP48_RS13940	COG3268	Saccharopine dehydrogenase
HFP48_RS13975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HFP48_RS14005	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HFP48_RS14010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS14020	COG5398	heme oxygenase
HFP48_RS14025	COG0667	Aldo Keto reductase
HFP48_RS14030	COG1968	undecaprenyl-diphosphatase activity
HFP48_RS14050	COG0215	cysteine-tRNA ligase activity
HFP48_RS14100	COG1201	RNA secondary structure unwinding
HFP48_RS14160	COG2146	nitrite reductase [NAD(P)H] activity
HFP48_RS14165	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP48_RS14170	COG2814	Major facilitator Superfamily
HFP48_RS14180	COG0646	methionine synthase
HFP48_RS14180	COG1410	methionine synthase
HFP48_RS14185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HFP48_RS14195	COG0564	pseudouridine synthase activity
HFP48_RS14200	COG0140	phosphoribosyl-ATP diphosphatase activity
HFP48_RS14260	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HFP48_RS14270	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
HFP48_RS14280	COG2378	regulation of single-species biofilm formation
HFP48_RS14285	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HFP48_RS14320	COG0300	oxidoreductase activity
HFP48_RS14325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFP48_RS14340	COG3842	ATPase activity
HFP48_RS14350	COG1609	Transcriptional regulator
HFP48_RS14365	COG0395	ABC-type sugar transport system, permease component
HFP48_RS14370	COG0366	Alpha amylase catalytic
HFP48_RS14395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFP48_RS14405	COG0463	Glycosyl transferase, family 2
HFP48_RS14425	COG0287	Prephenate dehydrogenase
HFP48_RS14430	COG0512	Glutamine amidotransferase of anthranilate synthase
HFP48_RS14430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFP48_RS14435	COG1605	Chorismate mutase
HFP48_RS14460	COG0346	lactoylglutathione lyase activity
HFP48_RS14475	COG0183	Belongs to the thiolase family
HFP48_RS14490	COG1252	NADH dehydrogenase
HFP48_RS14505	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS14510	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS14515	COG1120	ATPase activity
HFP48_RS14530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HFP48_RS14535	COG0697	spore germination
HFP48_RS14545	COG1253	flavin adenine dinucleotide binding
HFP48_RS14550	COG1253	flavin adenine dinucleotide binding
HFP48_RS14565	COG0277	FAD linked oxidase domain protein
HFP48_RS14580	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HFP48_RS14590	COG1408	metallophosphoesterase
HFP48_RS14615	COG1716	ATPase activity
HFP48_RS14645	COG0494	nUDIX hydrolase
HFP48_RS14675	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS14675	COG1454	alcohol dehydrogenase
HFP48_RS14685	COG1160	GTP binding
HFP48_RS14690	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HFP48_RS14700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HFP48_RS14745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HFP48_RS14760	COG0647	UMP catabolic process
HFP48_RS14785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HFP48_RS14790	COG2094	Belongs to the DNA glycosylase MPG family
HFP48_RS14805	COG0165	Argininosuccinate lyase
HFP48_RS14815	COG1438	arginine binding
HFP48_RS14820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HFP48_RS14830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HFP48_RS14835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HFP48_RS14840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HFP48_RS14850	COG0072	phenylalanine-tRNA ligase activity
HFP48_RS14850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HFP48_RS14855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HFP48_RS14865	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HFP48_RS14885	COG0469	pyruvate kinase activity
HFP48_RS14915	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS14925	COG0589	response to stress
HFP48_RS14935	COG2267	carboxylic ester hydrolase activity
HFP48_RS14980	COG3540	Alkaline phosphatase
HFP48_RS15005	COG0713	ATP synthesis coupled electron transport
HFP48_RS15015	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP48_RS15015	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFP48_RS15020	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HFP48_RS15025	COG1034	ATP synthesis coupled electron transport
HFP48_RS15040	COG0649	NAD binding
HFP48_RS15045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP48_RS15050	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HFP48_RS15065	COG0659	secondary active sulfate transmembrane transporter activity
HFP48_RS15120	COG0237	dephospho-CoA kinase activity
HFP48_RS15120	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HFP48_RS15130	COG0539	negative regulation of cytoplasmic translation
HFP48_RS15135	COG2226	methyltransferase
HFP48_RS15140	COG3548	integral membrane protein
HFP48_RS15145	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP48_RS15170	COG0473	3-isopropylmalate dehydrogenase activity
HFP48_RS15180	COG4977	sequence-specific DNA binding
HFP48_RS15185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HFP48_RS15195	COG1172	Belongs to the binding-protein-dependent transport system permease family
HFP48_RS15245	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS15275	COG0022	dehydrogenase e1 component
HFP48_RS15275	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP48_RS15280	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFP48_RS15285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP48_RS15300	COG0604	alcohol dehydrogenase
HFP48_RS15310	COG1946	Acyl-CoA thioesterase
HFP48_RS15320	COG0789	Transcriptional regulator
HFP48_RS15325	COG0783	Belongs to the Dps family
HFP48_RS15350	COG0070	glutamate synthase
HFP48_RS15350	COG0069	glutamate synthase activity
HFP48_RS15350	COG0067	glutamate synthase
HFP48_RS15360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HFP48_RS15365	COG0159	tryptophan synthase activity
HFP48_RS15375	COG0134	indole-3-glycerol-phosphate synthase activity
HFP48_RS15385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HFP48_RS15395	COG3384	dioxygenase
HFP48_RS15430	COG0107	imidazoleglycerol-phosphate synthase activity
HFP48_RS15435	COG0483	inositol monophosphate 1-phosphatase activity
HFP48_RS15440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HFP48_RS15450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HFP48_RS15465	COG0131	Imidazoleglycerol-phosphate dehydratase
HFP48_RS15475	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HFP48_RS15485	COG3243	poly(R)-hydroxyalkanoic acid synthase
HFP48_RS15500	COG2723	6-phospho-beta-galactosidase activity
HFP48_RS15505	COG1280	lysine exporter protein (LysE YggA)
HFP48_RS15530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HFP48_RS15555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HFP48_RS15570	COG1053	succinate dehydrogenase
HFP48_RS15605	COG2208	phosphoserine phosphatase activity
HFP48_RS15605	COG2770	Histidine kinase
HFP48_RS15610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HFP48_RS15615	COG0156	8-amino-7-oxononanoate synthase activity
HFP48_RS15620	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HFP48_RS15690	COG3012	SEC-C Motif Domain Protein
HFP48_RS15725	COG0477	Major facilitator Superfamily
HFP48_RS15745	COG0028	Belongs to the TPP enzyme family
HFP48_RS15755	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HFP48_RS15760	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HFP48_RS15765	COG2124	cytochrome p450
HFP48_RS15770	COG2409	Drug exporters of the RND superfamily
HFP48_RS15780	COG2197	response regulator
HFP48_RS15825	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HFP48_RS15845	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HFP48_RS15855	COG3599	regulation of cell shape
HFP48_RS15865	COG1799	cell septum assembly
HFP48_RS15880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HFP48_RS15885	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HFP48_RS15890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HFP48_RS15905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HFP48_RS15925	COG0768	penicillin binding
HFP48_RS15935	COG0275	rRNA processing
HFP48_RS15940	COG2001	Belongs to the MraZ family
HFP48_RS15975	COG0463	Glycosyl transferase, family 2
HFP48_RS16015	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HFP48_RS16030	COG1940	carbohydrate kinase activity
HFP48_RS16040	COG0003	Pfam Anion-transporting ATPase
HFP48_RS16055	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS16070	COG0791	NLP P60 protein
HFP48_RS16085	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HFP48_RS16095	COG1845	cytochrome c oxidase, subunit III
HFP48_RS16120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HFP48_RS16130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HFP48_RS16150	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HFP48_RS16155	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HFP48_RS16160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HFP48_RS16165	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HFP48_RS16170	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HFP48_RS16185	COG0321	lipoyl(octanoyl) transferase activity
HFP48_RS16190	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFP48_RS16205	COG0174	glutamine synthetase
HFP48_RS16225	COG0531	amino acid
HFP48_RS16250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HFP48_RS16255	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HFP48_RS16260	COG0174	glutamine synthetase
HFP48_RS16270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HFP48_RS16290	COG0557	exoribonuclease II activity
HFP48_RS16400	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HFP48_RS16415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HFP48_RS16450	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HFP48_RS16460	COG1595	DNA-templated transcription, initiation
HFP48_RS16470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFP48_RS16495	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HFP48_RS16510	COG0423	glycine-tRNA ligase activity
HFP48_RS16535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HFP48_RS16540	COG1381	Involved in DNA repair and RecF pathway recombination
HFP48_RS16545	COG3069	C4-dicarboxylate transmembrane transporter activity
HFP48_RS16550	COG1335	isochorismatase
HFP48_RS16600	COG0477	Major facilitator Superfamily
HFP48_RS16620	COG0484	heat shock protein binding
HFP48_RS16625	COG1420	regulation of RNA biosynthetic process
HFP48_RS16665	COG0589	response to stress
HFP48_RS16670	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HFP48_RS16680	COG3387	PFAM Glycoside hydrolase 15-related
HFP48_RS16685	COG2070	2-Nitropropane dioxygenase
HFP48_RS16690	COG0481	GTPase activity
HFP48_RS16700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HFP48_RS16705	COG1305	Transglutaminase-like
HFP48_RS16720	COG0268	Binds directly to 16S ribosomal RNA
HFP48_RS16745	COG2755	lipolytic protein G-D-S-L family
HFP48_RS16750	COG0406	alpha-ribazole phosphatase activity
HFP48_RS16755	COG0799	negative regulation of ribosome biogenesis
HFP48_RS16760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HFP48_RS16770	COG0542	response to heat
HFP48_RS16775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HFP48_RS16780	COG1181	Belongs to the D-alanine--D-alanine ligase family
HFP48_RS16785	COG0626	cystathionine gamma-synthase activity
HFP48_RS16790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFP48_RS16795	COG1920	GTP binding
HFP48_RS16800	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HFP48_RS16815	COG0066	3-isopropylmalate dehydratase activity
HFP48_RS16820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HFP48_RS16825	COG1414	Transcriptional regulator
HFP48_RS16855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HFP48_RS16860	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFP48_RS16865	COG2271	Major facilitator Superfamily
HFP48_RS16885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HFP48_RS16890	COG0440	acetolactate synthase activity
HFP48_RS16905	COG0129	dihydroxy-acid dehydratase activity
HFP48_RS16930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFP48_RS16940	COG2197	response regulator
HFP48_RS16945	COG4585	Histidine kinase
HFP48_RS16960	COG0154	amidase activity
HFP48_RS16965	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HFP48_RS16975	COG0456	acetyltransferase
HFP48_RS16980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HFP48_RS16990	COG0482	sulfurtransferase activity
HFP48_RS17010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HFP48_RS17020	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HFP48_RS17040	COG0110	maltose O-acetyltransferase activity
HFP48_RS17045	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HFP48_RS17050	COG0346	lactoylglutathione lyase activity
HFP48_RS17055	COG0640	Transcriptional regulator
HFP48_RS17065	COG2226	methyltransferase
HFP48_RS17080	COG1119	ATPase activity
HFP48_RS17095	COG3830	Belongs to the UPF0237 family
HFP48_RS17095	COG0560	Phosphoserine phosphatase
HFP48_RS17100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFP48_RS17130	COG1780	Probably involved in ribonucleotide reductase function
HFP48_RS17140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFP48_RS17145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HFP48_RS17150	COG2080	2 iron, 2 sulfur cluster binding
HFP48_RS17160	COG1309	transcriptional regulator
HFP48_RS17190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HFP48_RS17200	COG0521	Mo-molybdopterin cofactor biosynthetic process
HFP48_RS17200	COG0315	cyclic pyranopterin monophosphate synthase activity
HFP48_RS17205	COG0314	molybdopterin synthase activity
HFP48_RS17210	COG0513	Belongs to the DEAD box helicase family
HFP48_RS17215	COG0523	cobalamin synthesis protein
HFP48_RS17235	COG3265	gluconokinase activity
HFP48_RS17240	COG2197	response regulator
HFP48_RS17245	COG2271	Major facilitator Superfamily
HFP48_RS17265	COG2124	cytochrome p450
HFP48_RS17270	COG1414	Transcriptional regulator
HFP48_RS17315	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFP48_RS17320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HFP48_RS17335	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HFP48_RS17340	COG2177	Part of the ABC transporter FtsEX involved in
HFP48_RS17345	COG2884	Cell division ATP-binding protein ftsE
HFP48_RS17355	COG0668	transmembrane transport
HFP48_RS17360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HFP48_RS17365	COG0483	inositol monophosphate 1-phosphatase activity
HFP48_RS17375	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS17385	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS17405	COG3480	Lon protease (S16) C-terminal proteolytic domain
HFP48_RS17425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HFP48_RS17445	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS17490	COG0596	Alpha beta hydrolase
HFP48_RS17495	COG3695	enzyme binding
HFP48_RS17500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS17505	COG0746	molybdenum cofactor guanylyltransferase activity
HFP48_RS17510	COG1289	transmembrane transporter activity
HFP48_RS17530	COG2146	nitrite reductase [NAD(P)H] activity
HFP48_RS17530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP48_RS17545	COG2186	Transcriptional regulator
HFP48_RS17580	COG0513	Belongs to the DEAD box helicase family
HFP48_RS17605	COG1597	lipid kinase activity
HFP48_RS17620	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFP48_RS17635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HFP48_RS17645	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HFP48_RS17650	COG1162	GTPase activity
HFP48_RS17680	COG1011	Hydrolase
HFP48_RS17695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HFP48_RS17705	COG5401	PFAM Sporulation and spore germination
HFP48_RS17710	COG5002	protein histidine kinase activity
HFP48_RS17715	COG0745	RESPONSE REGULATOR receiver
HFP48_RS17735	COG0531	amino acid
HFP48_RS17740	COG1482	cell wall glycoprotein biosynthetic process
HFP48_RS17750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFP48_RS17770	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HFP48_RS17775	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HFP48_RS17775	COG0778	Nitroreductase
HFP48_RS17785	COG2755	lipolytic protein G-D-S-L family
HFP48_RS17790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFP48_RS17805	COG1316	TRANSCRIPTIONal
HFP48_RS17820	COG0577	efflux transmembrane transporter activity
HFP48_RS17820	COG1136	(ABC) transporter
HFP48_RS17825	COG1136	(ABC) transporter
HFP48_RS17830	COG2197	response regulator
HFP48_RS17835	COG4585	Histidine kinase
HFP48_RS17845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HFP48_RS17855	COG2205	protein histidine kinase activity
HFP48_RS17860	COG0745	RESPONSE REGULATOR receiver
HFP48_RS17870	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HFP48_RS17870	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HFP48_RS17875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFP48_RS17890	COG2226	methyltransferase
HFP48_RS17920	COG4770	biotin carboxylase activity
HFP48_RS17960	COG1522	sequence-specific DNA binding
HFP48_RS17965	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS17990	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS17995	COG0277	FAD linked oxidase domain protein
HFP48_RS18005	COG1201	RNA secondary structure unwinding
HFP48_RS18010	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HFP48_RS18035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HFP48_RS18040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS18065	COG3842	ATPase activity
HFP48_RS18075	COG1840	ABC-type Fe3 transport system, periplasmic component
HFP48_RS18080	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS18080	COG1473	amidohydrolase
HFP48_RS18100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HFP48_RS18110	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HFP48_RS18115	COG1174	glycine betaine transport
HFP48_RS18125	COG1174	glycine betaine transport
HFP48_RS18150	COG0791	NLP P60 protein
HFP48_RS18170	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS18195	COG2009	succinate dehydrogenase
HFP48_RS18210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HFP48_RS18215	COG1064	alcohol dehydrogenase
HFP48_RS18220	COG2130	NADP-dependent
HFP48_RS18225	COG1309	transcriptional regulator
HFP48_RS18230	COG1295	ribonuclease BN
HFP48_RS18235	COG0180	Tryptophanyl-tRNA synthetase
HFP48_RS18240	COG0708	Exodeoxyribonuclease III
HFP48_RS18250	COG2873	o-acetylhomoserine
HFP48_RS18255	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFP48_RS18265	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HFP48_RS18270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HFP48_RS18275	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HFP48_RS18280	COG1595	DNA-templated transcription, initiation
HFP48_RS18305	COG0587	DNA-directed DNA polymerase activity
HFP48_RS18310	COG1595	DNA-templated transcription, initiation
HFP48_RS18325	COG0640	Transcriptional regulator
HFP48_RS18345	COG1131	(ABC) transporter
HFP48_RS18350	COG3559	Exporter of polyketide antibiotics
HFP48_RS18360	COG4221	oxidoreductase activity
HFP48_RS18415	COG0789	Transcriptional regulator
HFP48_RS18430	COG1983	PspC domain protein
HFP48_RS18440	COG0519	Catalyzes the synthesis of GMP from XMP
HFP48_RS18440	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HFP48_RS18450	COG0516	GMP reductase activity
HFP48_RS18485	COG0459	protein refolding
HFP48_RS18490	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HFP48_RS18500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HFP48_RS18505	COG0456	acetyltransferase
HFP48_RS18520	COG2267	carboxylic ester hydrolase activity
HFP48_RS18525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HFP48_RS18535	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HFP48_RS18565	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HFP48_RS18590	COG1674	ftsk spoiiie
HFP48_RS18600	COG1404	Belongs to the peptidase S8 family
HFP48_RS18625	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS18640	COG0101	tRNA pseudouridine synthase activity
HFP48_RS18645	COG0203	ribosomal protein L17
HFP48_RS18650	COG0202	RNA polymerase activity
HFP48_RS18670	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HFP48_RS18675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HFP48_RS18690	COG0563	adenylate kinase activity
HFP48_RS18710	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HFP48_RS18715	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HFP48_RS18720	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HFP48_RS18725	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HFP48_RS18730	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HFP48_RS18735	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HFP48_RS18740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HFP48_RS18745	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HFP48_RS18750	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HFP48_RS18765	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HFP48_RS18775	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HFP48_RS18780	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HFP48_RS18785	COG0089	rRNA binding
HFP48_RS18790	COG0088	Forms part of the polypeptide exit tunnel
HFP48_RS18800	COG0051	transcription antitermination factor activity, RNA binding
HFP48_RS18805	COG0154	amidase activity
HFP48_RS18845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFP48_RS18855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HFP48_RS18875	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HFP48_RS18895	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS18905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFP48_RS18925	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS18935	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS18940	COG0477	Major facilitator Superfamily
HFP48_RS18960	COG4303	Ethanolamine ammonia lyase large subunit
HFP48_RS18965	COG0531	amino acid
HFP48_RS19035	COG3795	YCII-related domain
HFP48_RS19040	COG4941	Belongs to the sigma-70 factor family
HFP48_RS19045	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS19085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS19090	COG3135	benzoate transporter
HFP48_RS19095	COG0456	acetyltransferase
HFP48_RS19100	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
HFP48_RS19115	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS19115	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS19125	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS19125	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS19140	COG0535	radical SAM domain protein
HFP48_RS19160	COG3559	Exporter of polyketide antibiotics
HFP48_RS19165	COG1131	(ABC) transporter
HFP48_RS19175	COG1733	regulation of RNA biosynthetic process
HFP48_RS19190	COG2197	response regulator
HFP48_RS19200	COG1454	alcohol dehydrogenase
HFP48_RS19220	COG0542	response to heat
HFP48_RS19250	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HFP48_RS19260	COG1302	Protein conserved in bacteria
HFP48_RS19285	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HFP48_RS19295	COG0049	tRNA binding
HFP48_RS19300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HFP48_RS19320	COG1309	transcriptional regulator
HFP48_RS19325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS19330	COG1024	Enoyl-CoA hydratase
HFP48_RS19345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HFP48_RS19365	COG5006	permease, DMT superfamily
HFP48_RS19370	COG0477	Major facilitator Superfamily
HFP48_RS19375	COG0583	DNA-binding transcription factor activity
HFP48_RS19385	COG2226	methyltransferase
HFP48_RS19395	COG2149	membrane
HFP48_RS19400	COG0723	plastoquinol--plastocyanin reductase activity
HFP48_RS19420	COG0477	Major facilitator Superfamily
HFP48_RS19440	COG4607	ABC-type enterochelin transport system periplasmic component
HFP48_RS19445	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HFP48_RS19495	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP48_RS19500	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HFP48_RS19520	COG0081	regulation of translation
HFP48_RS19550	COG2030	dehydratase
HFP48_RS19575	COG1666	GTP binding
HFP48_RS19580	COG0501	Belongs to the peptidase M48B family
HFP48_RS19595	COG2226	methyltransferase
HFP48_RS19600	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS19615	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS19630	COG4948	Mandelate Racemase Muconate Lactonizing
HFP48_RS19710	COG1950	PFAM Membrane protein of
HFP48_RS19755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HFP48_RS19765	COG0785	Cytochrome C biogenesis protein
HFP48_RS19775	COG0406	alpha-ribazole phosphatase activity
HFP48_RS19780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HFP48_RS19795	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HFP48_RS19815	COG2133	pyrroloquinoline quinone binding
HFP48_RS19820	COG1937	Protein conserved in bacteria
HFP48_RS19840	COG1648	precorrin-2 dehydrogenase activity
HFP48_RS19840	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HFP48_RS19845	COG0181	hydroxymethylbilane synthase activity
HFP48_RS19850	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HFP48_RS19855	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HFP48_RS19910	COG1082	Xylose isomerase domain protein TIM barrel
HFP48_RS19930	COG0745	RESPONSE REGULATOR receiver
HFP48_RS19935	COG5002	protein histidine kinase activity
HFP48_RS19940	COG0588	phosphoglycerate mutase activity
HFP48_RS19950	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS19955	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS19970	COG1652	LysM domain
HFP48_RS19980	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS19985	COG1733	regulation of RNA biosynthetic process
HFP48_RS20005	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFP48_RS20045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HFP48_RS20075	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HFP48_RS20100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HFP48_RS20110	COG0788	formyltetrahydrofolate deformylase activity
HFP48_RS20120	COG2267	carboxylic ester hydrolase activity
HFP48_RS20145	COG2733	membrane
HFP48_RS20160	COG2326	polyphosphate kinase activity
HFP48_RS20175	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS20200	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP48_RS20230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HFP48_RS20230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HFP48_RS20245	COG0723	plastoquinol--plastocyanin reductase activity
HFP48_RS20250	COG0693	protein deglycase activity
HFP48_RS20255	COG3707	response regulator
HFP48_RS20315	COG1064	alcohol dehydrogenase
HFP48_RS20320	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HFP48_RS20330	COG2224	Isocitrate lyase
HFP48_RS20335	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP48_RS20335	COG1017	nitric oxide dioxygenase activity
HFP48_RS20375	COG1802	Transcriptional regulator
HFP48_RS20385	COG1802	Transcriptional regulator
HFP48_RS20405	COG0702	epimerase
HFP48_RS20445	COG1505	serine-type exopeptidase activity
HFP48_RS20450	COG2267	carboxylic ester hydrolase activity
HFP48_RS20495	COG0647	UMP catabolic process
HFP48_RS20500	COG0326	Molecular chaperone. Has ATPase activity
HFP48_RS20505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HFP48_RS20510	COG1228	amidohydrolase
HFP48_RS20520	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HFP48_RS20525	COG2986	histidine ammonia-lyase
HFP48_RS20545	COG0688	phosphatidylethanolamine metabolic process
HFP48_RS20555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFP48_RS20565	COG2816	NAD+ diphosphatase activity
HFP48_RS20570	COG2111	Na H antiporter
HFP48_RS20570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HFP48_RS20595	COG1320	monovalent cation:proton antiporter activity
HFP48_RS20605	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS20610	COG2032	superoxide dismutase activity
HFP48_RS20645	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HFP48_RS20650	COG0351	phosphomethylpyrimidine kinase
HFP48_RS20660	COG2234	aminopeptidase activity
HFP48_RS20670	COG1131	(ABC) transporter
HFP48_RS20675	COG1396	sequence-specific DNA binding
HFP48_RS20680	COG0235	Class ii aldolase
HFP48_RS20685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFP48_RS20690	COG2022	thiamine diphosphate biosynthetic process
HFP48_RS20705	COG0352	thiamine-phosphate diphosphorylase activity
HFP48_RS20720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HFP48_RS20735	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HFP48_RS20745	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS20755	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS20765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS20785	COG3284	Transcriptional regulator
HFP48_RS20800	COG0145	ligase activity
HFP48_RS20805	COG4647	ligase activity
HFP48_RS20810	COG0145	ligase activity
HFP48_RS20840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HFP48_RS20845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS20850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HFP48_RS20855	COG2354	Protein conserved in bacteria
HFP48_RS20865	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP48_RS20885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HFP48_RS20890	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HFP48_RS20905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS20915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS20920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFP48_RS20950	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS21020	COG1797	cobyrinic acid a,c-diamide synthase activity
HFP48_RS21025	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HFP48_RS21040	COG1492	cobalamin metabolic process
HFP48_RS21065	COG4129	membrane
HFP48_RS21090	COG0586	Pfam SNARE associated Golgi protein
HFP48_RS21095	COG0523	cobalamin synthesis protein
HFP48_RS21130	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HFP48_RS21165	COG0542	response to heat
HFP48_RS21175	COG2197	response regulator
HFP48_RS21185	COG1222	aaa ATPase
HFP48_RS21195	COG0791	NLP P60 protein
HFP48_RS21275	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS21285	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HFP48_RS21335	COG1053	succinate dehydrogenase
HFP48_RS21340	COG3631	Ketosteroid isomerase-related protein
HFP48_RS21345	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS21350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS21355	COG0789	Transcriptional regulator
HFP48_RS21360	COG0484	heat shock protein binding
HFP48_RS21365	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HFP48_RS21370	COG0443	Heat shock 70 kDa protein
HFP48_RS21400	COG0443	Heat shock 70 kDa protein
HFP48_RS21430	COG2181	nitrate reductase activity
HFP48_RS21430	COG0247	lactate metabolic process
HFP48_RS21440	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP48_RS21460	COG0745	RESPONSE REGULATOR receiver
HFP48_RS21465	COG4251	negative regulation of phosphorylation
HFP48_RS21470	COG0784	Response regulator, receiver
HFP48_RS21485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFP48_RS21490	COG0489	protein tyrosine kinase activity
HFP48_RS21510	COG2390	Transcriptional regulator
HFP48_RS21510	COG4584	PFAM Integrase catalytic
HFP48_RS21530	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HFP48_RS21530	COG2755	lipolytic protein G-D-S-L family
HFP48_RS21575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HFP48_RS21580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HFP48_RS21585	COG1482	cell wall glycoprotein biosynthetic process
HFP48_RS21590	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HFP48_RS21650	COG2814	Major facilitator Superfamily
HFP48_RS21655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS21670	COG0704	Plays a role in the regulation of phosphate uptake
HFP48_RS21700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS21720	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HFP48_RS21830	COG1414	Transcriptional regulator
HFP48_RS21835	COG1309	transcriptional regulator
HFP48_RS21850	COG3848	Pyruvate phosphate dikinase
HFP48_RS21850	COG0574	Belongs to the PEP-utilizing enzyme family
HFP48_RS21855	COG4221	oxidoreductase activity
HFP48_RS21930	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HFP48_RS21945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP48_RS21970	COG2124	cytochrome p450
HFP48_RS22020	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS22030	COG3387	PFAM Glycoside hydrolase 15-related
HFP48_RS22035	COG4608	Belongs to the ABC transporter superfamily
HFP48_RS22060	COG0747	negative chemotaxis
HFP48_RS22070	COG2267	carboxylic ester hydrolase activity
HFP48_RS22075	COG3467	pyridoxamine 5'-phosphate
HFP48_RS22080	COG1752	Esterase of the alpha-beta hydrolase superfamily
HFP48_RS22110	COG2855	membrane
HFP48_RS22135	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22145	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22155	COG2175	clavaminate synthase activity
HFP48_RS22160	COG3246	L-lysine catabolic process to acetate
HFP48_RS22165	COG2814	Major facilitator Superfamily
HFP48_RS22175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HFP48_RS22195	COG0640	Transcriptional regulator
HFP48_RS22200	COG2814	Major facilitator Superfamily
HFP48_RS22230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS22240	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22250	COG2072	flavoprotein involved in K transport
HFP48_RS22255	COG1309	transcriptional regulator
HFP48_RS22260	COG1309	transcriptional regulator
HFP48_RS22265	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22275	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HFP48_RS22290	COG1607	acyl-coa hydrolase
HFP48_RS22310	COG4948	Mandelate Racemase Muconate Lactonizing
HFP48_RS22320	COG2271	Major facilitator Superfamily
HFP48_RS22365	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22370	COG3231	kanamycin kinase activity
HFP48_RS22405	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22415	COG2902	Dehydrogenase
HFP48_RS22420	COG1053	succinate dehydrogenase
HFP48_RS22450	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS22470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HFP48_RS22475	COG2957	Belongs to the agmatine deiminase family
HFP48_RS22480	COG0174	glutamine synthetase
HFP48_RS22510	COG0183	Belongs to the thiolase family
HFP48_RS22520	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22530	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS22545	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22550	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS22550	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS22555	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS22560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFP48_RS22575	COG2030	dehydratase
HFP48_RS22580	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22585	COG0183	Belongs to the thiolase family
HFP48_RS22590	COG1309	transcriptional regulator
HFP48_RS22595	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS22700	COG0346	lactoylglutathione lyase activity
HFP48_RS22715	COG4569	acetaldehyde dehydrogenase (acetylating) activity
HFP48_RS22720	COG3971	2-oxopent-4-enoate hydratase activity
HFP48_RS22730	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS22760	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFP48_RS22765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HFP48_RS22775	COG4166	transmembrane transport
HFP48_RS22790	COG4948	Mandelate Racemase Muconate Lactonizing
HFP48_RS22795	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HFP48_RS22805	COG0151	Belongs to the GarS family
HFP48_RS22825	COG3284	Transcriptional regulator
HFP48_RS22835	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HFP48_RS22840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HFP48_RS22845	COG0508	dehydrogenase complex catalyzes the overall conversion of
HFP48_RS22850	COG0022	dehydrogenase e1 component
HFP48_RS22855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HFP48_RS22885	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS22890	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS22960	COG1357	PFAM Pentapeptide repeats (8 copies)
HFP48_RS23025	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS23055	COG0500	methyltransferase
HFP48_RS23060	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS23070	COG0183	Belongs to the thiolase family
HFP48_RS23075	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS23080	COG2030	dehydratase
HFP48_RS23095	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HFP48_RS23115	COG1309	transcriptional regulator
HFP48_RS23120	COG1472	Belongs to the glycosyl hydrolase 3 family
HFP48_RS23125	COG0589	response to stress
HFP48_RS23140	COG4981	capsule polysaccharide biosynthetic process
HFP48_RS23165	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS23180	COG0412	Dienelactone hydrolase
HFP48_RS23200	COG1045	serine acetyltransferase
HFP48_RS23225	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HFP48_RS23245	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HFP48_RS23265	COG2304	oxidoreductase activity
HFP48_RS23305	COG2353	YceI-like domain
HFP48_RS23315	COG3104	oligopeptide transport
HFP48_RS23330	COG0768	penicillin binding
HFP48_RS23335	COG0488	(ABC) transporter
HFP48_RS23340	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFP48_RS23365	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS23430	COG2267	carboxylic ester hydrolase activity
HFP48_RS23450	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HFP48_RS23465	COG2188	Transcriptional regulator
HFP48_RS23475	COG2301	Belongs to the HpcH HpaI aldolase family
HFP48_RS23480	COG2030	dehydratase
HFP48_RS23490	COG1024	Enoyl-CoA hydratase
HFP48_RS23500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFP48_RS23520	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HFP48_RS23540	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS23560	COG1024	Enoyl-CoA hydratase
HFP48_RS23600	COG2135	peptidase activity
HFP48_RS23605	COG0351	phosphomethylpyrimidine kinase
HFP48_RS23610	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS23660	COG3590	peptidase
HFP48_RS23670	COG2311	Membrane
HFP48_RS23705	COG0028	Belongs to the TPP enzyme family
HFP48_RS23710	COG0704	Plays a role in the regulation of phosphate uptake
HFP48_RS23720	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS23735	COG5002	protein histidine kinase activity
HFP48_RS23740	COG0745	RESPONSE REGULATOR receiver
HFP48_RS23745	COG3852	Histidine kinase
HFP48_RS23765	COG4638	Rieske (2fe-2S)
HFP48_RS23775	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS23785	COG4566	intracellular signal transduction
HFP48_RS23795	COG0154	amidase activity
HFP48_RS23815	COG0438	transferase activity, transferring glycosyl groups
HFP48_RS23835	COG3842	ATPase activity
HFP48_RS23840	COG1653	transport
HFP48_RS23855	COG1376	ErfK ybiS ycfS ynhG family protein
HFP48_RS23865	COG3360	Dodecin
HFP48_RS23885	COG1793	dna ligase
HFP48_RS23895	COG0598	Magnesium transport protein CorA
HFP48_RS23945	COG2217	Heavy metal translocating P-type atpase
HFP48_RS23955	COG2132	Multicopper oxidase
HFP48_RS23965	COG0745	RESPONSE REGULATOR receiver
HFP48_RS23970	COG5002	protein histidine kinase activity
HFP48_RS23980	COG2197	response regulator
HFP48_RS23985	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS24015	COG0667	Aldo Keto reductase
HFP48_RS24025	COG0129	dihydroxy-acid dehydratase activity
HFP48_RS24035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS24035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HFP48_RS24045	COG0425	Belongs to the sulfur carrier protein TusA family
HFP48_RS24055	COG0243	molybdopterin cofactor binding
HFP48_RS24075	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HFP48_RS24130	COG0183	Belongs to the thiolase family
HFP48_RS24150	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS24155	COG2508	Transcriptional regulator
HFP48_RS24155	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HFP48_RS24180	COG0450	alkyl hydroperoxide reductase
HFP48_RS24195	COG0302	gtp cyclohydrolase
HFP48_RS24225	COG4584	PFAM Integrase catalytic
HFP48_RS24225	COG2390	Transcriptional regulator
HFP48_RS24240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HFP48_RS24250	COG2873	o-acetylhomoserine
HFP48_RS24265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFP48_RS24270	COG0640	Transcriptional regulator
HFP48_RS24275	COG0798	PFAM Bile acid sodium symporter
HFP48_RS24280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFP48_RS24285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HFP48_RS24295	COG2072	flavoprotein involved in K transport
HFP48_RS24320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HFP48_RS24325	COG0167	dihydroorotate dehydrogenase activity
HFP48_RS24330	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFP48_RS24330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFP48_RS24330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFP48_RS24330	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFP48_RS24335	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HFP48_RS24335	COG0493	'glutamate synthase
HFP48_RS24345	COG0640	Transcriptional regulator
HFP48_RS24355	COG4604	ABC transporter, ATP-binding protein
HFP48_RS24360	COG4605	iron ion homeostasis
HFP48_RS24365	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HFP48_RS24370	COG4607	ABC-type enterochelin transport system periplasmic component
HFP48_RS24375	COG0604	alcohol dehydrogenase
HFP48_RS24380	COG0328	RNA-DNA hybrid ribonuclease activity
HFP48_RS24400	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS24405	COG1024	Enoyl-CoA hydratase
HFP48_RS24410	COG2267	carboxylic ester hydrolase activity
HFP48_RS24445	COG4208	sulfate ABC transporter
HFP48_RS24450	COG3842	ATPase activity
HFP48_RS24470	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS24485	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS24490	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS24500	COG2814	Major facilitator Superfamily
HFP48_RS24505	COG1024	Enoyl-CoA hydratase
HFP48_RS24515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS24525	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS24530	COG0183	Belongs to the thiolase family
HFP48_RS24550	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS24590	COG1309	transcriptional regulator
HFP48_RS24595	COG1250	3-hydroxyacyl-CoA dehydrogenase
HFP48_RS24610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HFP48_RS24630	COG2855	membrane
HFP48_RS24640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS24650	COG2175	clavaminate synthase activity
HFP48_RS24655	COG3246	L-lysine catabolic process to acetate
HFP48_RS24680	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS24745	COG2267	carboxylic ester hydrolase activity
HFP48_RS24760	COG1063	alcohol dehydrogenase
HFP48_RS24785	COG1309	transcriptional regulator
HFP48_RS24820	COG3185	4-Hydroxyphenylpyruvate dioxygenase
HFP48_RS24830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HFP48_RS24835	COG1113	amino acid transport
HFP48_RS24845	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS24850	COG0183	Belongs to the thiolase family
HFP48_RS24855	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS24910	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP48_RS24920	COG1846	Transcriptional regulator
HFP48_RS24930	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS24940	COG1556	Lactate utilization protein
HFP48_RS24945	COG1139	Iron-sulfur cluster binding protein
HFP48_RS24950	COG0247	lactate metabolic process
HFP48_RS24955	COG1620	l-lactate permease
HFP48_RS24965	COG2188	Transcriptional regulator
HFP48_RS24975	COG0628	permease
HFP48_RS25005	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS25010	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS25020	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFP48_RS25025	COG1414	Transcriptional regulator
HFP48_RS25030	COG0183	Belongs to the thiolase family
HFP48_RS25035	COG2271	Major facilitator Superfamily
HFP48_RS25040	COG0251	oxidation-reduction process
HFP48_RS25135	COG0583	DNA-binding transcription factor activity
HFP48_RS25140	COG2267	carboxylic ester hydrolase activity
HFP48_RS25145	COG3384	dioxygenase
HFP48_RS25150	COG0657	acetylesterase activity
HFP48_RS25160	COG4829	muconolactone delta-isomerase
HFP48_RS25165	COG4948	Mandelate Racemase Muconate Lactonizing
HFP48_RS25170	COG3485	protocatechuate 3,4-dioxygenase
HFP48_RS25175	COG1414	Transcriptional regulator
HFP48_RS25185	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS25215	COG4638	Rieske (2fe-2S)
HFP48_RS25235	COG2814	Major facilitator Superfamily
HFP48_RS25255	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HFP48_RS25285	COG0596	Alpha beta hydrolase
HFP48_RS25300	COG2175	clavaminate synthase activity
HFP48_RS25315	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS25325	COG0346	lactoylglutathione lyase activity
HFP48_RS25335	COG5650	phosphatidylinositol metabolic process
HFP48_RS25345	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HFP48_RS25355	COG0166	Belongs to the GPI family
HFP48_RS25360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS25365	COG2072	flavoprotein involved in K transport
HFP48_RS25390	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HFP48_RS25405	COG2186	Transcriptional regulator
HFP48_RS25410	COG1024	Enoyl-CoA hydratase
HFP48_RS25430	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS25435	COG2072	flavoprotein involved in K transport
HFP48_RS25450	COG2072	flavoprotein involved in K transport
HFP48_RS25455	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS25455	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS25465	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS25490	COG1013	pyruvate-flavodoxin oxidoreductase activity
HFP48_RS25495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HFP48_RS25495	COG0674	pyruvate-flavodoxin oxidoreductase activity
HFP48_RS25540	COG1053	succinate dehydrogenase
HFP48_RS25550	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS25555	COG2124	cytochrome p450
HFP48_RS25565	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS25570	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS25585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS25590	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS25595	COG2030	dehydratase
HFP48_RS25615	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS25635	COG0183	Belongs to the thiolase family
HFP48_RS25645	COG1024	Enoyl-CoA hydratase
HFP48_RS25685	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HFP48_RS25700	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HFP48_RS25740	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS25755	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS25760	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS25765	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS25770	COG0183	Belongs to the thiolase family
HFP48_RS25800	COG1309	transcriptional regulator
HFP48_RS25805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS25810	COG0183	Belongs to the thiolase family
HFP48_RS25815	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS25830	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS25850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HFP48_RS25860	COG2318	DinB family
HFP48_RS25875	COG0789	Transcriptional regulator
HFP48_RS25880	COG0667	Aldo Keto reductase
HFP48_RS25885	COG1609	Transcriptional regulator
HFP48_RS25890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HFP48_RS25935	COG1358	cellular component organization or biogenesis
HFP48_RS25970	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS26020	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS26035	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26090	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS26105	COG0667	Aldo Keto reductase
HFP48_RS26125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS26130	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26140	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26150	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26160	COG1024	Enoyl-CoA hydratase
HFP48_RS26185	COG0183	Belongs to the thiolase family
HFP48_RS26190	COG1024	Enoyl-CoA hydratase
HFP48_RS26200	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26225	COG4638	Rieske (2fe-2S)
HFP48_RS26245	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26250	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26260	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26270	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26275	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26300	COG0183	Belongs to the thiolase family
HFP48_RS26305	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS26325	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26335	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26340	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26355	COG0601	transmembrane transport
HFP48_RS26365	COG0444	Belongs to the ABC transporter superfamily
HFP48_RS26380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS26385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFP48_RS26390	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFP48_RS26390	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HFP48_RS26395	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HFP48_RS26415	COG0583	DNA-binding transcription factor activity
HFP48_RS26425	COG0183	Belongs to the thiolase family
HFP48_RS26435	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26450	COG0183	Belongs to the thiolase family
HFP48_RS26455	COG2271	Major facilitator Superfamily
HFP48_RS26460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS26465	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS26485	COG0673	inositol 2-dehydrogenase activity
HFP48_RS26490	COG0656	L-ascorbic acid biosynthetic process
HFP48_RS26500	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HFP48_RS26505	COG0477	Major facilitator Superfamily
HFP48_RS26510	COG0583	DNA-binding transcription factor activity
HFP48_RS26515	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS26525	COG1414	Transcriptional regulator
HFP48_RS26550	COG2193	ferroxidase activity
HFP48_RS26555	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HFP48_RS26570	COG2890	protein-(glutamine-N5) methyltransferase activity
HFP48_RS26610	COG1595	DNA-templated transcription, initiation
HFP48_RS26615	COG0477	Major facilitator Superfamily
HFP48_RS26630	COG1940	carbohydrate kinase activity
HFP48_RS26630	COG1846	Transcriptional regulator
HFP48_RS26635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HFP48_RS26645	COG0800	Aldolase
HFP48_RS26660	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HFP48_RS26665	COG1116	anion transmembrane transporter activity
HFP48_RS26670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFP48_RS26675	COG2186	Transcriptional regulator
HFP48_RS26680	COG1940	carbohydrate kinase activity
HFP48_RS26685	COG0477	Major facilitator Superfamily
HFP48_RS26690	COG1940	carbohydrate kinase activity
HFP48_RS26700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HFP48_RS26705	COG4266	Belongs to the allantoicase family
HFP48_RS26755	COG1982	Orn Lys Arg decarboxylase major
HFP48_RS26780	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HFP48_RS26780	COG2080	2 iron, 2 sulfur cluster binding
HFP48_RS26795	COG3835	regulator
HFP48_RS26835	COG3387	PFAM Glycoside hydrolase 15-related
HFP48_RS26865	COG0431	NADPH-dependent FMN reductase
HFP48_RS26870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS26910	COG1017	nitric oxide dioxygenase activity
HFP48_RS26910	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP48_RS26925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HFP48_RS26930	COG0477	Major facilitator Superfamily
HFP48_RS26935	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS26940	COG1131	(ABC) transporter
HFP48_RS26940	COG1716	ATPase activity
HFP48_RS26940	COG0842	Transport permease protein
HFP48_RS26960	COG0069	glutamate synthase activity
HFP48_RS26975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HFP48_RS26975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HFP48_RS26995	COG0450	alkyl hydroperoxide reductase
HFP48_RS27005	COG0745	RESPONSE REGULATOR receiver
HFP48_RS27030	COG1464	Belongs to the NlpA lipoprotein family
HFP48_RS27035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HFP48_RS27040	COG2011	ABC-type metal ion transport system permease component
HFP48_RS27045	COG2855	membrane
HFP48_RS27050	COG0405	Gamma-glutamyltransferase
HFP48_RS27070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HFP48_RS27080	COG2814	Major facilitator Superfamily
HFP48_RS27090	COG0359	binds to the 23S rRNA
HFP48_RS27095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HFP48_RS27100	COG0629	single-stranded DNA binding
HFP48_RS27135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFP48_RS27160	COG1695	Transcriptional regulator
HFP48_RS27200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HFP48_RS27225	COG3842	ATPase activity
HFP48_RS27295	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS27300	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS27335	COG0765	amino acid transport
HFP48_RS27340	COG1126	abc transporter atp-binding protein
HFP48_RS27375	COG0183	Belongs to the thiolase family
HFP48_RS27390	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS27395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS27405	COG0583	DNA-binding transcription factor activity
HFP48_RS27420	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS27425	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS27430	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS27445	COG1802	Transcriptional regulator
HFP48_RS27450	COG2175	clavaminate synthase activity
HFP48_RS27455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HFP48_RS27470	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFP48_RS27490	COG2855	membrane
HFP48_RS27520	COG2130	NADP-dependent
HFP48_RS27525	COG2271	Major facilitator Superfamily
HFP48_RS27545	COG3835	regulator
HFP48_RS27560	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS27565	COG1113	amino acid transport
HFP48_RS27595	COG2026	Addiction module toxin, RelE StbE family
HFP48_RS27600	COG2161	toxin-antitoxin pair type II binding
HFP48_RS27615	COG1012	belongs to the aldehyde dehydrogenase family
HFP48_RS27620	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS27625	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HFP48_RS27630	COG2902	Dehydrogenase
HFP48_RS27640	COG0459	protein refolding
HFP48_RS27645	COG1064	alcohol dehydrogenase
HFP48_RS27670	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HFP48_RS27675	COG3350	monooxygenase activity
HFP48_RS27685	COG0753	catalase activity
HFP48_RS27700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HFP48_RS27735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HFP48_RS27745	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS27785	COG1796	DNA polymerase
HFP48_RS27785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HFP48_RS27795	COG0300	oxidoreductase activity
HFP48_RS27805	COG1253	flavin adenine dinucleotide binding
HFP48_RS27810	COG3631	Ketosteroid isomerase-related protein
HFP48_RS27815	COG1253	flavin adenine dinucleotide binding
HFP48_RS27825	COG2267	carboxylic ester hydrolase activity
HFP48_RS27830	COG0495	leucyl-tRNA aminoacylation
HFP48_RS27855	COG0076	glutamate decarboxylase activity
HFP48_RS27860	COG1678	Uncharacterized ACR, COG1678
HFP48_RS27910	COG0243	molybdopterin cofactor binding
HFP48_RS27915	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HFP48_RS27925	COG0617	tRNA 3'-terminal CCA addition
HFP48_RS27945	COG1595	DNA-templated transcription, initiation
HFP48_RS27955	COG1309	transcriptional regulator
HFP48_RS27960	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS27960	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS27980	COG3118	belongs to the thioredoxin family
HFP48_RS27980	COG0492	ferredoxin-NADP+ reductase activity
HFP48_RS27985	COG0860	N-Acetylmuramoyl-L-alanine amidase
HFP48_RS27985	COG3409	Peptidoglycan-binding domain 1 protein
HFP48_RS28000	COG1192	Involved in chromosome partitioning
HFP48_RS28005	COG0357	Ribosomal RNA small subunit methyltransferase G
HFP48_RS28015	COG0706	membrane insertase activity
HFP48_RS28020	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HFP48_RS28030	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HFP48_RS28110	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28115	COG0183	Belongs to the thiolase family
HFP48_RS28140	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28145	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28150	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28155	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS28160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS28165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HFP48_RS28205	COG0477	Major facilitator Superfamily
HFP48_RS28230	COG0412	Dienelactone hydrolase
HFP48_RS28235	COG2149	membrane
HFP48_RS28240	COG0477	Major facilitator Superfamily
HFP48_RS28245	COG1234	tRNA 3'-trailer cleavage
HFP48_RS28305	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28325	COG0183	Belongs to the thiolase family
HFP48_RS28335	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28355	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS28360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS28365	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28370	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28385	COG2124	cytochrome p450
HFP48_RS28395	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28400	COG2186	Transcriptional regulator
HFP48_RS28415	COG1058	Belongs to the CinA family
HFP48_RS28415	COG1546	Belongs to the CinA family
HFP48_RS28480	COG0477	Major facilitator Superfamily
HFP48_RS28485	COG1733	regulation of RNA biosynthetic process
HFP48_RS28545	COG1309	transcriptional regulator
HFP48_RS28555	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28560	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28565	COG0183	Belongs to the thiolase family
HFP48_RS28575	COG2814	Major facilitator Superfamily
HFP48_RS28595	COG2072	flavoprotein involved in K transport
HFP48_RS28615	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HFP48_RS28655	COG1024	Enoyl-CoA hydratase
HFP48_RS28705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS28740	COG3344	reverse transcriptase
HFP48_RS28750	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28795	COG1929	Belongs to the glycerate kinase type-1 family
HFP48_RS28840	COG1850	ribulose-bisphosphate carboxylase activity
HFP48_RS28845	COG1609	Transcriptional regulator
HFP48_RS28885	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS28890	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS28900	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS28905	COG0183	Belongs to the thiolase family
HFP48_RS28920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HFP48_RS28925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HFP48_RS28935	COG1309	transcriptional regulator
HFP48_RS28965	COG2072	flavoprotein involved in K transport
HFP48_RS28985	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS28990	COG2226	methyltransferase
HFP48_RS28990	COG0596	Alpha beta hydrolase
HFP48_RS28990	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFP48_RS29010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS29045	COG1063	alcohol dehydrogenase
HFP48_RS29055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS29055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HFP48_RS29065	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HFP48_RS29095	COG0778	Nitroreductase
HFP48_RS29120	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS29160	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HFP48_RS29165	COG0582	viral genome integration into host DNA
HFP48_RS29200	COG1309	transcriptional regulator
HFP48_RS29205	COG0183	Belongs to the thiolase family
HFP48_RS29210	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29235	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HFP48_RS29260	COG2826	transposase and inactivated derivatives, IS30 family
HFP48_RS29315	COG4608	Belongs to the ABC transporter superfamily
HFP48_RS29320	COG0444	Belongs to the ABC transporter superfamily
HFP48_RS29335	COG2271	Major facilitator Superfamily
HFP48_RS29340	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS29375	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29380	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29430	COG1024	Enoyl-CoA hydratase
HFP48_RS29445	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29490	COG2814	Major facilitator Superfamily
HFP48_RS29490	COG0477	Major facilitator Superfamily
HFP48_RS29495	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS29525	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29530	COG1024	Enoyl-CoA hydratase
HFP48_RS29535	COG2124	cytochrome p450
HFP48_RS29540	COG1024	Enoyl-CoA hydratase
HFP48_RS29555	COG1024	Enoyl-CoA hydratase
HFP48_RS29560	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29570	COG0183	Belongs to the thiolase family
HFP48_RS29575	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29580	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS29590	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29600	COG1024	Enoyl-CoA hydratase
HFP48_RS29605	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29610	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS29615	COG1024	Enoyl-CoA hydratase
HFP48_RS29620	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS29625	COG1309	transcriptional regulator
HFP48_RS29640	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29650	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29655	COG1946	Acyl-CoA thioesterase
HFP48_RS29660	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS29670	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29675	COG0183	Belongs to the thiolase family
HFP48_RS29690	COG0183	Belongs to the thiolase family
HFP48_RS29695	COG0302	gtp cyclohydrolase
HFP48_RS29700	COG0183	Belongs to the thiolase family
HFP48_RS29740	COG1396	sequence-specific DNA binding
HFP48_RS29780	COG1192	Involved in chromosome partitioning
HFP48_RS29825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HFP48_RS29845	COG0583	DNA-binding transcription factor activity
HFP48_RS29850	COG1024	Enoyl-CoA hydratase
HFP48_RS29855	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS29865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HFP48_RS29870	COG0463	Glycosyl transferase, family 2
HFP48_RS29920	COG2267	carboxylic ester hydrolase activity
HFP48_RS29965	COG2226	methyltransferase
HFP48_RS30020	COG0318	PFAM AMP-dependent synthetase and ligase
HFP48_RS30025	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS30035	COG1309	transcriptional regulator
HFP48_RS30065	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HFP48_RS30070	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HFP48_RS30075	COG0179	Fumarylacetoacetate (FAA) hydrolase
HFP48_RS30080	COG3384	dioxygenase
HFP48_RS30090	COG2124	cytochrome p450
HFP48_RS30130	COG0683	leucine binding
HFP48_RS30140	COG1129	ABC transporter
HFP48_RS30165	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS30185	COG5285	phytanoyl-CoA dioxygenase
HFP48_RS30200	COG0183	Belongs to the thiolase family
HFP48_RS30215	COG3328	transposase activity
HFP48_RS30225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS30235	COG2188	Transcriptional regulator
HFP48_RS30245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HFP48_RS30265	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS30280	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS30285	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS30290	COG1024	Enoyl-CoA hydratase
HFP48_RS30325	COG0446	pyridine nucleotide-disulphide oxidoreductase
HFP48_RS30325	COG1902	pentaerythritol trinitrate reductase activity
HFP48_RS30330	COG1960	acyl-CoA dehydrogenase activity
HFP48_RS30340	COG1028	Short-chain dehydrogenase reductase Sdr
HFP48_RS30355	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HFP48_RS30485	COG1396	sequence-specific DNA binding
HFP48_RS30575	COG0582	viral genome integration into host DNA
HFP48_RS30720	COG1132	(ABC) transporter
HFP48_RS30815	COG3547	Transposase (IS116 IS110 IS902 family)
HFP48_RS30825	COG0531	amino acid
HFP48_RS30835	COG2032	superoxide dismutase activity
HFP48_RS30875	COG2323	membrane
HFP48_RS30890	COG0784	Response regulator, receiver
HFP48_RS30905	COG1280	lysine exporter protein (LysE YggA)
HFP48_RS30955	COG2050	protein possibly involved in aromatic compounds catabolism
HFP48_RS30975	COG1335	isochorismatase
HFP48_RS30990	COG1024	Enoyl-CoA hydratase
HFP48_RS30995	COG1024	Enoyl-CoA hydratase
HFP48_RS31010	COG1278	Cold shock
HFP48_RS31045	COG3177	Filamentation induced by cAMP protein fic
HFP48_RS31065	COG2409	Drug exporters of the RND superfamily
HFP48_RS31080	COG1595	DNA-templated transcription, initiation
HFP48_RS31130	COG2337	Toxic component of a toxin-antitoxin (TA) module
HFP48_RS31155	COG2161	toxin-antitoxin pair type II binding
HFP48_RS31195	COG0154	amidase activity
HFP48_RS31210	COG5290	Psort location Cytoplasmic, score