locus-tag	class	description
EHW12_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EHW12_RS00010	COG0592	DNA-directed DNA polymerase activity
EHW12_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
EHW12_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EHW12_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
EHW12_RS00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
EHW12_RS00105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHW12_RS00110	COG0457	Tetratricopeptide repeat
EHW12_RS00110	COG0705	Rhomboid family
EHW12_RS00130	COG0277	FAD linked oxidase domain protein
EHW12_RS00150	COG3879	Bacterial protein of unknown function (DUF881)
EHW12_RS00160	COG0515	serine threonine protein kinase
EHW12_RS00160	COG2815	serine threonine protein kinase
EHW12_RS00165	COG0515	serine threonine protein kinase
EHW12_RS00170	COG0768	penicillin binding
EHW12_RS00185	COG1716	ATPase activity
EHW12_RS00215	COG0067	glutamate synthase
EHW12_RS00215	COG0069	glutamate synthase activity
EHW12_RS00215	COG0070	glutamate synthase
EHW12_RS00250	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
EHW12_RS00270	COG0025	NhaP-type Na H and K H
EHW12_RS00280	COG0601	transmembrane transport
EHW12_RS00285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS00290	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS00305	COG2199	diguanylate cyclase activity
EHW12_RS00315	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EHW12_RS00315	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHW12_RS00320	COG2501	S4 domain
EHW12_RS00325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW12_RS00345	COG2365	Tyrosine phosphatase family
EHW12_RS00390	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS00405	COG4716	Myosin-crossreactive antigen
EHW12_RS00420	COG2271	Major facilitator Superfamily
EHW12_RS00435	COG0506	proline dehydrogenase activity
EHW12_RS00460	COG2197	response regulator
EHW12_RS00475	COG1136	(ABC) transporter
EHW12_RS00475	COG0577	efflux transmembrane transporter activity
EHW12_RS00525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS00530	COG1120	ATPase activity
EHW12_RS00565	COG2318	DinB family
EHW12_RS00570	COG1288	antiporter activity
EHW12_RS00595	COG3119	arylsulfatase activity
EHW12_RS00605	COG0175	sulfate reduction
EHW12_RS00610	COG4424	Sulfotransferase
EHW12_RS00645	COG5001	Diguanylate cyclase
EHW12_RS00665	COG1403	HNH endonuclease
EHW12_RS00680	COG0183	Belongs to the thiolase family
EHW12_RS00695	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS00700	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS00705	COG0154	amidase activity
EHW12_RS00730	COG0154	amidase activity
EHW12_RS00740	COG2271	Major facilitator Superfamily
EHW12_RS00750	COG2119	membrane
EHW12_RS00770	COG0628	permease
EHW12_RS00780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EHW12_RS00790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHW12_RS00800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS00830	COG1528	Iron-storage protein
EHW12_RS00865	COG1528	Iron-storage protein
EHW12_RS00875	COG1316	TRANSCRIPTIONal
EHW12_RS00960	COG0204	Acyl-transferase
EHW12_RS00975	COG0561	phosphatase activity
EHW12_RS00985	COG2385	sporulation resulting in formation of a cellular spore
EHW12_RS00995	COG1113	amino acid transport
EHW12_RS01000	COG0183	Belongs to the thiolase family
EHW12_RS01005	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS01010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS01020	COG1216	Glycosyl transferase, family 2
EHW12_RS01030	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EHW12_RS01035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHW12_RS01040	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS01045	COG5479	isomerase activity
EHW12_RS01045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS01055	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EHW12_RS01065	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS01070	COG3321	synthase
EHW12_RS01070	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EHW12_RS01070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW12_RS01075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHW12_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS01140	COG0277	FAD linked oxidase domain protein
EHW12_RS01175	COG0183	Belongs to the thiolase family
EHW12_RS01180	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS01190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW12_RS01195	COG1215	transferase activity, transferring glycosyl groups
EHW12_RS01210	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
EHW12_RS01215	COG1088	dTDP-glucose 4,6-dehydratase activity
EHW12_RS01225	COG0463	Glycosyl transferase, family 2
EHW12_RS01240	COG1216	Glycosyl transferase, family 2
EHW12_RS01250	COG1162	GTPase activity
EHW12_RS01255	COG1216	Glycosyl transferase, family 2
EHW12_RS01410	COG0831	urea catabolic process
EHW12_RS01420	COG0804	urea catabolic process
EHW12_RS01425	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EHW12_RS01435	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EHW12_RS01445	COG4413	Urea transporter
EHW12_RS01450	COG3265	gluconokinase activity
EHW12_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS01460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHW12_RS01470	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHW12_RS01475	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHW12_RS01485	COG0477	Major facilitator Superfamily
EHW12_RS01490	COG4221	oxidoreductase activity
EHW12_RS01495	COG1063	alcohol dehydrogenase
EHW12_RS01500	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EHW12_RS01505	COG0436	Aminotransferase
EHW12_RS01520	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS01530	COG0737	Belongs to the 5'-nucleotidase family
EHW12_RS01535	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHW12_RS01555	COG4977	sequence-specific DNA binding
EHW12_RS01565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS01570	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS01575	COG1120	ATPase activity
EHW12_RS01615	COG0270	DNA (cytosine-5-)-methyltransferase activity
EHW12_RS01625	COG0287	Prephenate dehydrogenase
EHW12_RS01635	COG0590	tRNA wobble adenosine to inosine editing
EHW12_RS01660	COG2149	membrane
EHW12_RS01680	COG3706	GGDEF domain
EHW12_RS01690	COG2409	Drug exporters of the RND superfamily
EHW12_RS01710	COG2814	Major facilitator Superfamily
EHW12_RS01740	COG3384	dioxygenase
EHW12_RS01745	COG0596	Alpha beta hydrolase
EHW12_RS01745	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS01750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EHW12_RS01760	COG1116	anion transmembrane transporter activity
EHW12_RS01775	COG0492	ferredoxin-NADP+ reductase activity
EHW12_RS01785	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS01785	COG0596	Alpha beta hydrolase
EHW12_RS01790	COG1414	Transcriptional regulator
EHW12_RS01805	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS01815	COG1024	Enoyl-CoA hydratase
EHW12_RS01820	COG0343	queuine tRNA-ribosyltransferase activity
EHW12_RS01850	COG3300	MHYT domain
EHW12_RS01850	COG5001	Diguanylate cyclase
EHW12_RS01855	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW12_RS01860	COG3226	Transcriptional regulator
EHW12_RS01890	COG0745	RESPONSE REGULATOR receiver
EHW12_RS01905	COG1357	PFAM Pentapeptide repeats (8 copies)
EHW12_RS01925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS01940	COG0583	DNA-binding transcription factor activity
EHW12_RS01945	COG2855	membrane
EHW12_RS01960	COG2175	clavaminate synthase activity
EHW12_RS01965	COG3246	L-lysine catabolic process to acetate
EHW12_RS01970	COG2814	Major facilitator Superfamily
EHW12_RS01980	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS02010	COG2132	Multicopper oxidase
EHW12_RS02015	COG0183	Belongs to the thiolase family
EHW12_RS02030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW12_RS02060	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW12_RS02065	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EHW12_RS02070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EHW12_RS02075	COG1309	transcriptional regulator
EHW12_RS02080	COG2814	Major facilitator Superfamily
EHW12_RS02085	COG1309	transcriptional regulator
EHW12_RS02105	COG0183	Belongs to the thiolase family
EHW12_RS02120	COG0183	Belongs to the thiolase family
EHW12_RS02125	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS02130	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS02135	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS02155	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHW12_RS02160	COG0697	spore germination
EHW12_RS02165	COG0583	DNA-binding transcription factor activity
EHW12_RS02175	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW12_RS02235	COG2132	Multicopper oxidase
EHW12_RS02240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS02245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW12_RS02270	COG4566	intracellular signal transduction
EHW12_RS02305	COG0546	phosphoglycolate phosphatase activity
EHW12_RS02310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS02315	COG2205	protein histidine kinase activity
EHW12_RS02355	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS02380	COG1408	metallophosphoesterase
EHW12_RS02415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS02435	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
EHW12_RS02445	COG0477	Major facilitator Superfamily
EHW12_RS02450	COG0583	DNA-binding transcription factor activity
EHW12_RS02460	COG1309	transcriptional regulator
EHW12_RS02490	COG0494	nUDIX hydrolase
EHW12_RS02500	COG0596	Alpha beta hydrolase
EHW12_RS02510	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHW12_RS02515	COG0477	Major facilitator Superfamily
EHW12_RS02550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHW12_RS02555	COG0747	negative chemotaxis
EHW12_RS02560	COG0601	transmembrane transport
EHW12_RS02565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS02570	COG4172	Belongs to the ABC transporter superfamily
EHW12_RS02620	COG1205	dead DEAH box helicase
EHW12_RS02620	COG1111	helicase
EHW12_RS02625	COG1278	Cold shock
EHW12_RS02635	COG1754	DNA topoisomerase type I activity
EHW12_RS02635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
EHW12_RS02640	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
EHW12_RS02650	COG1714	RDD family
EHW12_RS02685	COG3836	Belongs to the HpcH HpaI aldolase family
EHW12_RS02690	COG0667	Aldo Keto reductase
EHW12_RS02695	COG4608	Belongs to the ABC transporter superfamily
EHW12_RS02700	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS02705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS02710	COG0601	transmembrane transport
EHW12_RS02715	COG0747	negative chemotaxis
EHW12_RS02725	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EHW12_RS02730	COG1349	DNA-binding transcription factor activity
EHW12_RS02750	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS02755	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW12_RS02775	COG5001	Diguanylate cyclase
EHW12_RS02775	COG3300	MHYT domain
EHW12_RS02780	COG1802	Transcriptional regulator
EHW12_RS02790	COG2268	Band 7 protein
EHW12_RS02825	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS02900	COG0477	Major facilitator Superfamily
EHW12_RS02940	COG1937	Protein conserved in bacteria
EHW12_RS02960	COG2226	methyltransferase
EHW12_RS02970	COG1396	sequence-specific DNA binding
EHW12_RS02975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW12_RS03005	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW12_RS03010	COG0442	prolyl-tRNA aminoacylation
EHW12_RS03020	COG1309	transcriptional regulator
EHW12_RS03030	COG1285	pathogenesis
EHW12_RS03075	COG1358	cellular component organization or biogenesis
EHW12_RS03090	COG2755	lipolytic protein G-D-S-L family
EHW12_RS03150	COG0561	phosphatase activity
EHW12_RS03180	COG1309	transcriptional regulator
EHW12_RS03200	COG1316	TRANSCRIPTIONal
EHW12_RS03220	COG2027	D-alanyl-D-alanine carboxypeptidase
EHW12_RS03230	COG0037	tRNA processing
EHW12_RS03260	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS03270	COG2186	Transcriptional regulator
EHW12_RS03275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHW12_RS03280	COG0302	gtp cyclohydrolase
EHW12_RS03315	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EHW12_RS03320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
EHW12_RS03325	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EHW12_RS03355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EHW12_RS03390	COG1024	Enoyl-CoA hydratase
EHW12_RS03400	COG1309	transcriptional regulator
EHW12_RS03420	COG4585	Histidine kinase
EHW12_RS03425	COG2197	response regulator
EHW12_RS03495	COG1194	a g-specific adenine glycosylase
EHW12_RS03535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS03545	COG0288	reversible hydration of carbon dioxide
EHW12_RS03555	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
EHW12_RS03565	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
EHW12_RS03575	COG1329	Transcriptional regulator
EHW12_RS03580	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EHW12_RS03585	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EHW12_RS03590	COG0215	cysteine-tRNA ligase activity
EHW12_RS03595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW12_RS03600	COG1132	(ABC) transporter
EHW12_RS03605	COG1132	(ABC) transporter
EHW12_RS03615	COG2207	Transcriptional regulator
EHW12_RS03635	COG1984	allophanate hydrolase subunit 2
EHW12_RS03640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
EHW12_RS03645	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
EHW12_RS03650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW12_RS03655	COG1121	(ABC) transporter
EHW12_RS03660	COG0803	Belongs to the bacterial solute-binding protein 9 family
EHW12_RS03665	COG1609	Transcriptional regulator
EHW12_RS03675	COG1309	transcriptional regulator
EHW12_RS03680	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS03685	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS03690	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS03705	COG0183	Belongs to the thiolase family
EHW12_RS03715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW12_RS03765	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW12_RS03780	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EHW12_RS03790	COG1136	(ABC) transporter
EHW12_RS03805	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EHW12_RS03830	COG2030	dehydratase
EHW12_RS03845	COG3971	2-oxopent-4-enoate hydratase activity
EHW12_RS03850	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EHW12_RS03855	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW12_RS03880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW12_RS03920	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS03925	COG2267	carboxylic ester hydrolase activity
EHW12_RS03930	COG0346	lactoylglutathione lyase activity
EHW12_RS03935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW12_RS03950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHW12_RS03960	COG2814	Major facilitator Superfamily
EHW12_RS03970	COG4689	acetoacetate decarboxylase
EHW12_RS03975	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS03980	COG2124	cytochrome p450
EHW12_RS04020	COG1116	anion transmembrane transporter activity
EHW12_RS04030	COG1074	ATP-dependent DNA helicase activity
EHW12_RS04050	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
EHW12_RS04060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHW12_RS04080	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
EHW12_RS04105	COG0656	L-ascorbic acid biosynthetic process
EHW12_RS04110	COG0686	Belongs to the AlaDH PNT family
EHW12_RS04130	COG0346	lactoylglutathione lyase activity
EHW12_RS04140	COG0561	phosphatase activity
EHW12_RS04160	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04165	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04170	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04175	COG1024	Enoyl-CoA hydratase
EHW12_RS04180	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS04185	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS04195	COG1309	transcriptional regulator
EHW12_RS04200	COG0183	Belongs to the thiolase family
EHW12_RS04240	COG0494	nUDIX hydrolase
EHW12_RS04290	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS04305	COG3214	Protein conserved in bacteria
EHW12_RS04325	COG1414	Transcriptional regulator
EHW12_RS04345	COG1024	Enoyl-CoA hydratase
EHW12_RS04350	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS04370	COG0183	Belongs to the thiolase family
EHW12_RS04375	COG2124	cytochrome p450
EHW12_RS04395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHW12_RS04400	COG0183	Belongs to the thiolase family
EHW12_RS04410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS04430	COG2070	2-Nitropropane dioxygenase
EHW12_RS04435	COG2186	Transcriptional regulator
EHW12_RS04440	COG4608	Belongs to the ABC transporter superfamily
EHW12_RS04445	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS04450	COG0601	transmembrane transport
EHW12_RS04455	COG0747	negative chemotaxis
EHW12_RS04465	COG0673	inositol 2-dehydrogenase activity
EHW12_RS04470	COG0673	inositol 2-dehydrogenase activity
EHW12_RS04475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW12_RS04480	COG1940	carbohydrate kinase activity
EHW12_RS04495	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHW12_RS04505	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS04510	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04515	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS04535	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS04560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW12_RS04580	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
EHW12_RS04585	COG1132	(ABC) transporter
EHW12_RS04590	COG1132	(ABC) transporter
EHW12_RS04605	COG1937	Protein conserved in bacteria
EHW12_RS04630	COG3486	L-lysine 6-monooxygenase (NADPH) activity
EHW12_RS04660	COG2076	Multidrug Resistance protein
EHW12_RS04675	COG0745	RESPONSE REGULATOR receiver
EHW12_RS04680	COG2205	protein histidine kinase activity
EHW12_RS04700	COG2271	Major facilitator Superfamily
EHW12_RS04705	COG3483	tryptophan 2,3-dioxygenase activity
EHW12_RS04720	COG4948	Mandelate Racemase Muconate Lactonizing
EHW12_RS04740	COG0537	adenosine 5'-monophosphoramidase activity
EHW12_RS04760	COG1124	(ABC) transporter
EHW12_RS04765	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS04770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS04775	COG0601	transmembrane transport
EHW12_RS04815	COG0671	phosphoesterase, PA-phosphatase related
EHW12_RS04820	COG0745	RESPONSE REGULATOR receiver
EHW12_RS04825	COG2205	protein histidine kinase activity
EHW12_RS04845	COG0436	Aminotransferase
EHW12_RS04855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHW12_RS04870	COG2382	esterase
EHW12_RS04875	COG4592	Periplasmic binding protein
EHW12_RS04880	COG4585	Histidine kinase
EHW12_RS04885	COG2197	response regulator
EHW12_RS04890	COG2365	Tyrosine phosphatase family
EHW12_RS04900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EHW12_RS04910	COG4565	transcriptional regulatory protein
EHW12_RS04915	COG3290	protein histidine kinase activity
EHW12_RS04920	COG1301	dicarboxylic acid transport
EHW12_RS04940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS04945	COG0386	Belongs to the glutathione peroxidase family
EHW12_RS04965	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EHW12_RS04970	COG0047	phosphoribosylformylglycinamidine synthase activity
EHW12_RS04980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS05000	COG2205	protein histidine kinase activity
EHW12_RS05005	COG0745	RESPONSE REGULATOR receiver
EHW12_RS05015	COG2217	Heavy metal translocating P-type atpase
EHW12_RS05030	COG0488	(ABC) transporter
EHW12_RS05055	COG3104	oligopeptide transport
EHW12_RS05070	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW12_RS05095	COG4585	Histidine kinase
EHW12_RS05100	COG2197	response regulator
EHW12_RS05120	COG1309	transcriptional regulator
EHW12_RS05130	COG2409	Drug exporters of the RND superfamily
EHW12_RS05140	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EHW12_RS05160	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EHW12_RS05170	COG1045	serine acetyltransferase
EHW12_RS05195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS05200	COG1120	ATPase activity
EHW12_RS05230	COG1940	carbohydrate kinase activity
EHW12_RS05235	COG0500	methyltransferase
EHW12_RS05290	COG1472	Belongs to the glycosyl hydrolase 3 family
EHW12_RS05295	COG1309	transcriptional regulator
EHW12_RS05300	COG2030	dehydratase
EHW12_RS05305	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS05310	COG0183	Belongs to the thiolase family
EHW12_RS05320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS05330	COG1476	TRANSCRIPTIONal
EHW12_RS05355	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS05370	COG1136	(ABC) transporter
EHW12_RS05370	COG0577	efflux transmembrane transporter activity
EHW12_RS05375	COG4585	Histidine kinase
EHW12_RS05380	COG2197	response regulator
EHW12_RS05405	COG2267	carboxylic ester hydrolase activity
EHW12_RS05435	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EHW12_RS05450	COG0009	L-threonylcarbamoyladenylate synthase
EHW12_RS05455	COG0789	Transcriptional regulator
EHW12_RS05460	COG0659	secondary active sulfate transmembrane transporter activity
EHW12_RS05485	COG0582	viral genome integration into host DNA
EHW12_RS05575	COG2837	iron assimilation
EHW12_RS05610	COG0501	Belongs to the peptidase M48B family
EHW12_RS05620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EHW12_RS05630	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EHW12_RS05660	COG3707	response regulator
EHW12_RS05665	COG0596	Alpha beta hydrolase
EHW12_RS05720	COG1120	ATPase activity
EHW12_RS05725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS05730	COG2226	methyltransferase
EHW12_RS05745	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS05765	COG0628	permease
EHW12_RS05790	COG0183	Belongs to the thiolase family
EHW12_RS05820	COG2015	COG2015, Alkyl sulfatase and related hydrolases
EHW12_RS05830	COG0477	Major facilitator Superfamily
EHW12_RS05835	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EHW12_RS05840	COG1737	Transcriptional regulator
EHW12_RS05845	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EHW12_RS05860	COG2815	serine threonine protein kinase
EHW12_RS05860	COG0515	serine threonine protein kinase
EHW12_RS05875	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EHW12_RS05895	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW12_RS05930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW12_RS05955	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHW12_RS05965	COG0156	8-amino-7-oxononanoate synthase activity
EHW12_RS06010	COG1053	succinate dehydrogenase
EHW12_RS06015	COG0739	heme binding
EHW12_RS06035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW12_RS06090	COG1131	(ABC) transporter
EHW12_RS06095	COG2188	Transcriptional regulator
EHW12_RS06105	COG0717	Belongs to the dCTP deaminase family
EHW12_RS06175	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW12_RS06190	COG1278	Cold shock
EHW12_RS06240	COG0783	Belongs to the Dps family
EHW12_RS06245	COG0789	Transcriptional regulator
EHW12_RS06285	COG1595	DNA-templated transcription, initiation
EHW12_RS06290	COG1302	Protein conserved in bacteria
EHW12_RS06355	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW12_RS06370	COG1215	transferase activity, transferring glycosyl groups
EHW12_RS06400	COG0297	glycogen (starch) synthase activity
EHW12_RS06420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EHW12_RS06425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW12_RS06430	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EHW12_RS06435	COG0489	protein tyrosine kinase activity
EHW12_RS06470	COG0297	glycogen (starch) synthase activity
EHW12_RS06475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
EHW12_RS06480	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EHW12_RS06485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW12_RS06490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EHW12_RS06495	COG0489	protein tyrosine kinase activity
EHW12_RS06500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHW12_RS06505	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
EHW12_RS06510	COG0443	Heat shock 70 kDa protein
EHW12_RS06525	COG4946	Tricorn protease homolog
EHW12_RS06525	COG0823	Involved in the tonB-independent uptake of proteins
EHW12_RS06525	COG1506	peptidase
EHW12_RS06595	COG0477	Major facilitator Superfamily
EHW12_RS06600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EHW12_RS06620	COG0443	Heat shock 70 kDa protein
EHW12_RS06625	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHW12_RS06630	COG0484	heat shock protein binding
EHW12_RS06635	COG0789	Transcriptional regulator
EHW12_RS06680	COG2072	flavoprotein involved in K transport
EHW12_RS06705	COG3976	FMN-binding domain protein
EHW12_RS06705	COG1053	succinate dehydrogenase
EHW12_RS06735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EHW12_RS06755	COG3631	Ketosteroid isomerase-related protein
EHW12_RS06760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW12_RS06770	COG1414	Transcriptional regulator
EHW12_RS06795	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS06805	COG3290	protein histidine kinase activity
EHW12_RS06815	COG2851	Citrate transporter
EHW12_RS06840	COG0542	response to heat
EHW12_RS06865	COG2814	Major facilitator Superfamily
EHW12_RS06875	COG1309	transcriptional regulator
EHW12_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS06915	COG0596	Alpha beta hydrolase
EHW12_RS06925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS06930	COG0523	cobalamin synthesis protein
EHW12_RS06935	COG0586	Pfam SNARE associated Golgi protein
EHW12_RS06960	COG4129	membrane
EHW12_RS06980	COG2354	Protein conserved in bacteria
EHW12_RS06985	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW12_RS06990	COG0183	Belongs to the thiolase family
EHW12_RS07015	COG1994	Peptidase M50
EHW12_RS07025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHW12_RS07040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS07050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS07070	COG3706	GGDEF domain
EHW12_RS07075	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
EHW12_RS07100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EHW12_RS07135	COG0681	Belongs to the peptidase S26 family
EHW12_RS07165	COG1126	abc transporter atp-binding protein
EHW12_RS07170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW12_RS07185	COG0747	negative chemotaxis
EHW12_RS07195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS07200	COG4172	Belongs to the ABC transporter superfamily
EHW12_RS07205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS07220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS07225	COG0037	tRNA processing
EHW12_RS07225	COG0590	tRNA wobble adenosine to inosine editing
EHW12_RS07245	COG2149	membrane
EHW12_RS07250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS07260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EHW12_RS07270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW12_RS07285	COG0352	thiamine-phosphate diphosphorylase activity
EHW12_RS07290	COG2022	thiamine diphosphate biosynthetic process
EHW12_RS07290	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHW12_RS07300	COG2022	thiamine diphosphate biosynthetic process
EHW12_RS07305	COG1131	(ABC) transporter
EHW12_RS07315	COG2234	aminopeptidase activity
EHW12_RS07325	COG0351	phosphomethylpyrimidine kinase
EHW12_RS07340	COG0456	acetyltransferase
EHW12_RS07340	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW12_RS07365	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EHW12_RS07375	COG1320	monovalent cation:proton antiporter activity
EHW12_RS07385	COG1863	multisubunit Na H antiporter MnhE subunit
EHW12_RS07390	COG0651	ATP synthesis coupled electron transport
EHW12_RS07395	COG1006	Multisubunit Na H antiporter MnhC subunit
EHW12_RS07400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EHW12_RS07400	COG2111	Na H antiporter
EHW12_RS07430	COG2124	cytochrome p450
EHW12_RS07460	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EHW12_RS07465	COG1183	phosphatidylcholine synthase activity
EHW12_RS07470	COG0688	phosphatidylethanolamine metabolic process
EHW12_RS07495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EHW12_RS07515	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
EHW12_RS07515	COG2508	Transcriptional regulator
EHW12_RS07530	COG0459	protein refolding
EHW12_RS07550	COG2326	polyphosphate kinase activity
EHW12_RS07555	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHW12_RS07560	COG1505	serine-type exopeptidase activity
EHW12_RS07590	COG1733	regulation of RNA biosynthetic process
EHW12_RS07595	COG0702	epimerase
EHW12_RS07615	COG1802	Transcriptional regulator
EHW12_RS07625	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS07635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS07665	COG1802	Transcriptional regulator
EHW12_RS07695	COG1309	transcriptional regulator
EHW12_RS07705	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS07725	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS07765	COG2224	Isocitrate lyase
EHW12_RS07775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW12_RS07780	COG1064	alcohol dehydrogenase
EHW12_RS07805	COG0297	glycogen (starch) synthase activity
EHW12_RS07825	COG2326	polyphosphate kinase activity
EHW12_RS07835	COG2733	membrane
EHW12_RS07855	COG0596	Alpha beta hydrolase
EHW12_RS07865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
EHW12_RS07905	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EHW12_RS07950	COG0583	DNA-binding transcription factor activity
EHW12_RS07965	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHW12_RS07980	COG0438	transferase activity, transferring glycosyl groups
EHW12_RS07990	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS08000	COG5002	protein histidine kinase activity
EHW12_RS08005	COG0745	RESPONSE REGULATOR receiver
EHW12_RS08095	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
EHW12_RS08100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EHW12_RS08105	COG0181	hydroxymethylbilane synthase activity
EHW12_RS08110	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHW12_RS08110	COG1587	Uroporphyrinogen-III synthase
EHW12_RS08140	COG1937	Protein conserved in bacteria
EHW12_RS08150	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHW12_RS08155	COG0175	sulfate reduction
EHW12_RS08170	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS08215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EHW12_RS08220	COG0406	alpha-ribazole phosphatase activity
EHW12_RS08230	COG0785	Cytochrome C biogenesis protein
EHW12_RS08240	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW12_RS08285	COG0542	response to heat
EHW12_RS08290	COG1950	PFAM Membrane protein of
EHW12_RS08350	COG0559	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS08360	COG0410	ABC transporter
EHW12_RS08385	COG4948	Mandelate Racemase Muconate Lactonizing
EHW12_RS08405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
EHW12_RS08415	COG0438	transferase activity, transferring glycosyl groups
EHW12_RS08430	COG0142	geranyltranstransferase activity
EHW12_RS08435	COG0501	Belongs to the peptidase M48B family
EHW12_RS08440	COG1666	GTP binding
EHW12_RS08460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EHW12_RS08465	COG2030	dehydratase
EHW12_RS08490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EHW12_RS08495	COG0081	regulation of translation
EHW12_RS08505	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EHW12_RS08520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS08525	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS08550	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EHW12_RS08575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EHW12_RS08585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS08605	COG0604	alcohol dehydrogenase
EHW12_RS08615	COG0604	alcohol dehydrogenase
EHW12_RS08625	COG0477	Major facilitator Superfamily
EHW12_RS08630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS08655	COG1024	Enoyl-CoA hydratase
EHW12_RS08670	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS08675	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHW12_RS08710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EHW12_RS08715	COG0049	tRNA binding
EHW12_RS08720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EHW12_RS08725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EHW12_RS08760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EHW12_RS08820	COG1454	alcohol dehydrogenase
EHW12_RS08825	COG4585	Histidine kinase
EHW12_RS08845	COG1131	(ABC) transporter
EHW12_RS08850	COG3559	Exporter of polyketide antibiotics
EHW12_RS08895	COG0535	radical SAM domain protein
EHW12_RS08910	COG1902	pentaerythritol trinitrate reductase activity
EHW12_RS08910	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW12_RS08920	COG1902	pentaerythritol trinitrate reductase activity
EHW12_RS08920	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW12_RS08960	COG0531	amino acid
EHW12_RS08965	COG4303	Ethanolamine ammonia lyase large subunit
EHW12_RS08990	COG0477	Major facilitator Superfamily
EHW12_RS08995	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS09005	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS09020	COG2409	Drug exporters of the RND superfamily
EHW12_RS09035	COG1216	Glycosyl transferase, family 2
EHW12_RS09045	COG1216	Glycosyl transferase, family 2
EHW12_RS09050	COG1301	dicarboxylic acid transport
EHW12_RS09060	COG2357	RelA SpoT domain protein
EHW12_RS09065	COG1309	transcriptional regulator
EHW12_RS09070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHW12_RS09080	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS09085	COG2030	dehydratase
EHW12_RS09110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW12_RS09120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW12_RS09125	COG0406	alpha-ribazole phosphatase activity
EHW12_RS09150	COG1442	glycosyl transferase family 8
EHW12_RS09150	COG1216	Glycosyl transferase, family 2
EHW12_RS09160	COG0287	Prephenate dehydrogenase
EHW12_RS09165	COG0512	Glutamine amidotransferase of anthranilate synthase
EHW12_RS09165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHW12_RS09170	COG1605	Chorismate mutase
EHW12_RS09180	COG0051	transcription antitermination factor activity, RNA binding
EHW12_RS09185	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EHW12_RS09190	COG0088	Forms part of the polypeptide exit tunnel
EHW12_RS09195	COG0089	rRNA binding
EHW12_RS09200	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EHW12_RS09205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EHW12_RS09210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EHW12_RS09215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EHW12_RS09220	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EHW12_RS09225	COG0255	Belongs to the universal ribosomal protein uL29 family
EHW12_RS09230	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EHW12_RS09235	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EHW12_RS09240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EHW12_RS09245	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EHW12_RS09250	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHW12_RS09255	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EHW12_RS09260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EHW12_RS09265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EHW12_RS09270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EHW12_RS09275	COG1841	ribosomal large subunit assembly
EHW12_RS09280	COG0200	Binds to the 23S rRNA
EHW12_RS09285	COG0201	protein transport
EHW12_RS09290	COG0563	adenylate kinase activity
EHW12_RS09300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EHW12_RS09305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EHW12_RS09310	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EHW12_RS09315	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EHW12_RS09320	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EHW12_RS09325	COG0202	RNA polymerase activity
EHW12_RS09335	COG0101	tRNA pseudouridine synthase activity
EHW12_RS09340	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS09365	COG1404	Belongs to the peptidase S8 family
EHW12_RS09460	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EHW12_RS09465	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EHW12_RS09470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHW12_RS09495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
EHW12_RS09510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EHW12_RS09530	COG0456	acetyltransferase
EHW12_RS09535	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EHW12_RS09555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EHW12_RS09560	COG0459	protein refolding
EHW12_RS09615	COG0516	GMP reductase activity
EHW12_RS09635	COG0519	Catalyzes the synthesis of GMP from XMP
EHW12_RS09635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHW12_RS09665	COG2271	Major facilitator Superfamily
EHW12_RS09670	COG2205	protein histidine kinase activity
EHW12_RS09675	COG0745	RESPONSE REGULATOR receiver
EHW12_RS09690	COG1733	regulation of RNA biosynthetic process
EHW12_RS09705	COG0515	serine threonine protein kinase
EHW12_RS09705	COG2815	serine threonine protein kinase
EHW12_RS09735	COG3119	arylsulfatase activity
EHW12_RS09740	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHW12_RS09795	COG2249	NAD(P)H dehydrogenase (quinone) activity
EHW12_RS09805	COG0583	DNA-binding transcription factor activity
EHW12_RS09815	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EHW12_RS09820	COG2271	Major facilitator Superfamily
EHW12_RS09840	COG4585	Histidine kinase
EHW12_RS09845	COG2197	response regulator
EHW12_RS09850	COG4221	oxidoreductase activity
EHW12_RS09875	COG1120	ATPase activity
EHW12_RS09890	COG0587	DNA-directed DNA polymerase activity
EHW12_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS09905	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS09905	COG0604	alcohol dehydrogenase
EHW12_RS09905	COG3321	synthase
EHW12_RS09945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW12_RS09955	COG0243	molybdopterin cofactor binding
EHW12_RS09960	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EHW12_RS09985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHW12_RS10000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW12_RS10005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EHW12_RS10010	COG2873	o-acetylhomoserine
EHW12_RS10020	COG2814	Major facilitator Superfamily
EHW12_RS10025	COG0708	Exodeoxyribonuclease III
EHW12_RS10040	COG0180	Tryptophanyl-tRNA synthetase
EHW12_RS10045	COG1295	ribonuclease BN
EHW12_RS10050	COG1686	Belongs to the peptidase S11 family
EHW12_RS10070	COG1082	Xylose isomerase domain protein TIM barrel
EHW12_RS10075	COG0673	inositol 2-dehydrogenase activity
EHW12_RS10085	COG3962	Belongs to the TPP enzyme family
EHW12_RS10105	COG2188	Transcriptional regulator
EHW12_RS10115	COG0477	Major facilitator Superfamily
EHW12_RS10120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EHW12_RS10140	COG3622	Belongs to the hyi family
EHW12_RS10145	COG0673	inositol 2-dehydrogenase activity
EHW12_RS10150	COG1609	Transcriptional regulator
EHW12_RS10160	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS10180	COG0673	inositol 2-dehydrogenase activity
EHW12_RS10185	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS10195	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EHW12_RS10200	COG1053	succinate dehydrogenase
EHW12_RS10210	COG2009	succinate dehydrogenase
EHW12_RS10245	COG0791	NLP P60 protein
EHW12_RS10245	COG0741	lytic transglycosylase activity
EHW12_RS10255	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHW12_RS10260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHW12_RS10280	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
EHW12_RS10280	COG1473	amidohydrolase
EHW12_RS10305	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EHW12_RS10310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
EHW12_RS10315	COG0583	DNA-binding transcription factor activity
EHW12_RS10320	COG0477	Major facilitator Superfamily
EHW12_RS10325	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHW12_RS10355	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS10360	COG0656	L-ascorbic acid biosynthetic process
EHW12_RS10380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHW12_RS10385	COG1201	RNA secondary structure unwinding
EHW12_RS10390	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
EHW12_RS10410	COG2233	PERMEase
EHW12_RS10415	COG3491	Belongs to the iron ascorbate-dependent oxidoreductase family
EHW12_RS10425	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS10435	COG1522	sequence-specific DNA binding
EHW12_RS10445	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHW12_RS10465	COG2351	hydroxyisourate hydrolase activity
EHW12_RS10495	COG4770	biotin carboxylase activity
EHW12_RS10525	COG0477	Major facilitator Superfamily
EHW12_RS10535	COG0424	maF-like protein
EHW12_RS10545	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EHW12_RS10550	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EHW12_RS10550	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EHW12_RS10565	COG0745	RESPONSE REGULATOR receiver
EHW12_RS10570	COG2205	protein histidine kinase activity
EHW12_RS10580	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EHW12_RS10595	COG4585	Histidine kinase
EHW12_RS10600	COG2197	response regulator
EHW12_RS10605	COG1136	(ABC) transporter
EHW12_RS10605	COG0577	efflux transmembrane transporter activity
EHW12_RS10620	COG1316	TRANSCRIPTIONal
EHW12_RS10635	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EHW12_RS10650	COG0778	Nitroreductase
EHW12_RS10650	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
EHW12_RS10675	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EHW12_RS10685	COG1482	cell wall glycoprotein biosynthetic process
EHW12_RS10695	COG0531	amino acid
EHW12_RS10700	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW12_RS10735	COG5002	protein histidine kinase activity
EHW12_RS10740	COG5401	PFAM Sporulation and spore germination
EHW12_RS10750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EHW12_RS10755	COG0653	protein targeting
EHW12_RS10795	COG1162	GTPase activity
EHW12_RS10800	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EHW12_RS10830	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EHW12_RS10845	COG1597	lipid kinase activity
EHW12_RS10860	COG0406	alpha-ribazole phosphatase activity
EHW12_RS10865	COG1192	Involved in chromosome partitioning
EHW12_RS10875	COG0513	Belongs to the DEAD box helicase family
EHW12_RS10910	COG2186	Transcriptional regulator
EHW12_RS10925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHW12_RS10925	COG2146	nitrite reductase [NAD(P)H] activity
EHW12_RS10930	COG2146	nitrite reductase [NAD(P)H] activity
EHW12_RS10930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EHW12_RS10975	COG0596	Alpha beta hydrolase
EHW12_RS10980	COG0210	DNA helicase
EHW12_RS11020	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EHW12_RS11035	COG3480	Lon protease (S16) C-terminal proteolytic domain
EHW12_RS11045	COG1615	UPF0182 protein
EHW12_RS11050	COG1388	LysM domain
EHW12_RS11075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS11095	COG0402	S-adenosylhomocysteine deaminase activity
EHW12_RS11100	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS11105	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS11115	COG3851	Histidine kinase
EHW12_RS11120	COG2197	response regulator
EHW12_RS11125	COG2132	Multicopper oxidase
EHW12_RS11130	COG0483	inositol monophosphate 1-phosphatase activity
EHW12_RS11140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
EHW12_RS11145	COG0668	transmembrane transport
EHW12_RS11155	COG2884	Cell division ATP-binding protein ftsE
EHW12_RS11160	COG2177	Part of the ABC transporter FtsEX involved in
EHW12_RS11165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EHW12_RS11180	COG0667	Aldo Keto reductase
EHW12_RS11195	COG0702	epimerase
EHW12_RS11205	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
EHW12_RS11235	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW12_RS11240	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW12_RS11250	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHW12_RS11255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EHW12_RS11260	COG0033	Phosphoglucomutase
EHW12_RS11285	COG1252	NADH dehydrogenase
EHW12_RS11290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW12_RS11305	COG0778	Nitroreductase
EHW12_RS11310	COG0513	Belongs to the DEAD box helicase family
EHW12_RS11320	COG0315	cyclic pyranopterin monophosphate synthase activity
EHW12_RS11320	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW12_RS11330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EHW12_RS11365	COG1309	transcriptional regulator
EHW12_RS11390	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EHW12_RS11420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS11425	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW12_RS11450	COG1119	ATPase activity
EHW12_RS11465	COG2226	methyltransferase
EHW12_RS11480	COG0110	maltose O-acetyltransferase activity
EHW12_RS11510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EHW12_RS11530	COG0482	sulfurtransferase activity
EHW12_RS11540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EHW12_RS11555	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHW12_RS11560	COG0154	amidase activity
EHW12_RS11575	COG4585	Histidine kinase
EHW12_RS11580	COG2197	response regulator
EHW12_RS11585	COG0205	6-phosphofructokinase activity
EHW12_RS11590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EHW12_RS11605	COG2259	Doxx family
EHW12_RS11610	COG0531	amino acid
EHW12_RS11615	COG0129	dihydroxy-acid dehydratase activity
EHW12_RS11630	COG0440	acetolactate synthase activity
EHW12_RS11635	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EHW12_RS11645	COG0473	3-isopropylmalate dehydrogenase activity
EHW12_RS11650	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHW12_RS11655	COG3239	Fatty acid desaturase
EHW12_RS11660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EHW12_RS11685	COG1414	Transcriptional regulator
EHW12_RS11690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EHW12_RS11695	COG0066	3-isopropylmalate dehydratase activity
EHW12_RS11710	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
EHW12_RS11715	COG1920	GTP binding
EHW12_RS11720	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHW12_RS11725	COG0626	cystathionine gamma-synthase activity
EHW12_RS11730	COG1181	Belongs to the D-alanine--D-alanine ligase family
EHW12_RS11750	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
EHW12_RS11760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHW12_RS11765	COG1461	Dihydroxyacetone kinase
EHW12_RS11770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHW12_RS11775	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
EHW12_RS11780	COG0742	ribosomal rna small subunit methyltransferase
EHW12_RS11785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EHW12_RS11800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EHW12_RS11805	COG0571	ribonuclease III activity
EHW12_RS11810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHW12_RS11825	COG1254	Belongs to the acylphosphatase family
EHW12_RS11830	COG1196	nuclear chromosome segregation
EHW12_RS11850	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
EHW12_RS11865	COG0228	four-way junction DNA binding
EHW12_RS11875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EHW12_RS11880	COG0336	Belongs to the RNA methyltransferase TrmD family
EHW12_RS11905	COG0463	Glycosyl transferase, family 2
EHW12_RS11910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EHW12_RS11930	COG0335	large ribosomal subunit rRNA binding
EHW12_RS11935	COG0681	Belongs to the peptidase S26 family
EHW12_RS11940	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EHW12_RS11950	COG1690	Belongs to the RtcB family
EHW12_RS11975	COG0792	nuclease activity
EHW12_RS12035	COG0484	heat shock protein binding
EHW12_RS12170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHW12_RS12390	COG1674	ftsk spoiiie
EHW12_RS12470	COG2814	Major facilitator Superfamily
EHW12_RS12490	COG0052	Belongs to the universal ribosomal protein uS2 family
EHW12_RS12495	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EHW12_RS12500	COG0528	UMP kinase activity
EHW12_RS12505	COG0233	cytoplasmic translational termination
EHW12_RS12510	COG0575	Belongs to the CDS family
EHW12_RS12515	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EHW12_RS12530	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EHW12_RS12540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EHW12_RS12545	COG0750	zinc metalloprotease
EHW12_RS12565	COG2197	response regulator
EHW12_RS12570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHW12_RS12605	COG2188	Transcriptional regulator
EHW12_RS12630	COG1760	l-serine dehydratase
EHW12_RS12660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EHW12_RS12700	COG2207	Transcriptional regulator
EHW12_RS12705	COG2076	Multidrug Resistance protein
EHW12_RS12725	COG1492	cobalamin metabolic process
EHW12_RS12745	COG0384	phenazine biosynthesis protein PhzF
EHW12_RS12750	COG3467	pyridoxamine 5'-phosphate
EHW12_RS12770	COG0579	oxidoreductase
EHW12_RS12800	COG1648	precorrin-2 dehydrogenase activity
EHW12_RS12800	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EHW12_RS12810	COG0517	IMP dehydrogenase activity
EHW12_RS12815	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EHW12_RS12820	COG3022	response to hydroperoxide
EHW12_RS12825	COG0442	prolyl-tRNA aminoacylation
EHW12_RS12830	COG4122	O-methyltransferase activity
EHW12_RS12860	COG0697	spore germination
EHW12_RS12865	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS12880	COG0477	Major facilitator Superfamily
EHW12_RS12895	COG0779	Required for maturation of 30S ribosomal subunits
EHW12_RS12910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EHW12_RS12910	COG0481	GTPase activity
EHW12_RS12920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EHW12_RS12925	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EHW12_RS12935	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHW12_RS12945	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EHW12_RS12965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EHW12_RS12970	COG1185	polyribonucleotide nucleotidyltransferase activity
EHW12_RS12990	COG0375	protein maturation
EHW12_RS13010	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
EHW12_RS13040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EHW12_RS13045	COG0298	carbon dioxide binding
EHW12_RS13050	COG0409	Hydrogenase expression formation protein
EHW12_RS13055	COG0309	Hydrogenase expression formation protein (HypE)
EHW12_RS13115	COG3835	regulator
EHW12_RS13135	COG2365	Tyrosine phosphatase family
EHW12_RS13155	COG0789	Transcriptional regulator
EHW12_RS13160	COG0095	Lipoate-protein ligase
EHW12_RS13190	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EHW12_RS13220	COG1535	isochorismatase
EHW12_RS13220	COG3433	isochorismatase activity
EHW12_RS13225	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS13230	COG1021	2,3-dihydroxybenzoate-AMP ligase
EHW12_RS13235	COG3433	isochorismatase activity
EHW12_RS13235	COG1535	isochorismatase
EHW12_RS13250	COG4592	Periplasmic binding protein
EHW12_RS13260	COG2375	cellular response to nickel ion
EHW12_RS13280	COG1131	(ABC) transporter
EHW12_RS13325	COG0713	ATP synthesis coupled electron transport
EHW12_RS13335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW12_RS13340	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EHW12_RS13360	COG0649	NAD binding
EHW12_RS13370	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EHW12_RS13405	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
EHW12_RS13435	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EHW12_RS13445	COG1058	Belongs to the CinA family
EHW12_RS13445	COG1546	Belongs to the CinA family
EHW12_RS13450	COG1396	sequence-specific DNA binding
EHW12_RS13455	COG1842	Phage shock protein A
EHW12_RS13465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
EHW12_RS13470	COG1122	ATPase activity
EHW12_RS13475	COG1268	BioY protein
EHW12_RS13505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EHW12_RS13510	COG2137	regulation of response to DNA damage stimulus
EHW12_RS13515	COG0765	amino acid transport
EHW12_RS13520	COG0765	amino acid transport
EHW12_RS13525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW12_RS13530	COG1126	abc transporter atp-binding protein
EHW12_RS13535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EHW12_RS13545	COG1196	nuclear chromosome segregation
EHW12_RS13555	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EHW12_RS13565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EHW12_RS13570	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EHW12_RS13580	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS13585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EHW12_RS13590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW12_RS13590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
EHW12_RS13590	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
EHW12_RS13600	COG1349	DNA-binding transcription factor activity
EHW12_RS13605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW12_RS13610	COG2233	PERMEase
EHW12_RS13615	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS13625	COG1388	LysM domain
EHW12_RS13630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EHW12_RS13635	COG1643	Atp-dependent helicase
EHW12_RS13670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW12_RS13675	COG0450	alkyl hydroperoxide reductase
EHW12_RS13685	COG0277	FAD linked oxidase domain protein
EHW12_RS13735	COG0123	including yeast histone deacetylase and acetoin utilization protein
EHW12_RS13740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW12_RS13740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EHW12_RS13750	COG2813	Specifically methylates the guanine in position
EHW12_RS13790	COG0475	glutathione-regulated potassium exporter activity
EHW12_RS13795	COG2365	Tyrosine phosphatase family
EHW12_RS13810	COG0483	inositol monophosphate 1-phosphatase activity
EHW12_RS13830	COG0756	dUTP diphosphatase activity
EHW12_RS13865	COG0569	domain protein
EHW12_RS13870	COG0531	amino acid
EHW12_RS13875	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EHW12_RS13885	COG0477	Major facilitator Superfamily
EHW12_RS13895	COG2066	Belongs to the glutaminase family
EHW12_RS13895	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
EHW12_RS13900	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EHW12_RS13905	COG0477	Major facilitator Superfamily
EHW12_RS13930	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHW12_RS13930	COG1024	Enoyl-CoA hydratase
EHW12_RS13935	COG0183	Belongs to the thiolase family
EHW12_RS13990	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EHW12_RS14020	COG2223	nitrite transmembrane transporter activity
EHW12_RS14025	COG2723	6-phospho-beta-galactosidase activity
EHW12_RS14070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EHW12_RS14085	COG1560	Kdo2-lipid A biosynthetic process
EHW12_RS14090	COG0438	transferase activity, transferring glycosyl groups
EHW12_RS14095	COG1051	belongs to the nudix hydrolase family
EHW12_RS14100	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
EHW12_RS14120	COG1946	Acyl-CoA thioesterase
EHW12_RS14130	COG1946	Acyl-CoA thioesterase
EHW12_RS14140	COG2197	response regulator
EHW12_RS14145	COG4585	Histidine kinase
EHW12_RS14165	COG2188	Transcriptional regulator
EHW12_RS14170	COG0217	transcriptional regulatory protein
EHW12_RS14175	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EHW12_RS14180	COG0632	four-way junction helicase activity
EHW12_RS14200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EHW12_RS14205	COG0747	negative chemotaxis
EHW12_RS14210	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EHW12_RS14215	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EHW12_RS14220	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHW12_RS14225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
EHW12_RS14235	COG0124	histidyl-tRNA synthetase
EHW12_RS14245	COG0039	L-malate dehydrogenase activity
EHW12_RS14270	COG1131	(ABC) transporter
EHW12_RS14290	COG1053	succinate dehydrogenase
EHW12_RS14295	COG0488	(ABC) transporter
EHW12_RS14305	COG1652	LysM domain
EHW12_RS14335	COG2184	nucleotidyltransferase activity
EHW12_RS14365	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EHW12_RS14370	COG4106	trans-aconitate 2-methyltransferase activity
EHW12_RS14395	COG0662	Cupin 2, conserved barrel domain protein
EHW12_RS14415	COG1309	transcriptional regulator
EHW12_RS14420	COG2824	Alkylphosphonate utilization operon protein PhnA
EHW12_RS14455	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EHW12_RS14480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EHW12_RS14485	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EHW12_RS14495	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW12_RS14510	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EHW12_RS14515	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EHW12_RS14520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EHW12_RS14540	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EHW12_RS14545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EHW12_RS14555	COG0540	Belongs to the ATCase OTCase family
EHW12_RS14570	COG0505	Belongs to the CarA family
EHW12_RS14580	COG0284	orotidine-5'-phosphate decarboxylase activity
EHW12_RS14585	COG1051	belongs to the nudix hydrolase family
EHW12_RS14595	COG0194	GDP metabolic process
EHW12_RS14600	COG1758	RNA polymerase activity
EHW12_RS14610	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EHW12_RS14640	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW12_RS14670	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHW12_RS14670	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
EHW12_RS14690	COG1660	Displays ATPase and GTPase activities
EHW12_RS14705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EHW12_RS14710	COG0126	phosphoglycerate kinase activity
EHW12_RS14715	COG0149	triose-phosphate isomerase activity
EHW12_RS14720	COG2365	Tyrosine phosphatase family
EHW12_RS14730	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EHW12_RS14735	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS14755	COG1129	ABC transporter
EHW12_RS14765	COG4221	oxidoreductase activity
EHW12_RS14785	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EHW12_RS14795	COG0109	protoheme IX farnesyltransferase activity
EHW12_RS14850	COG0396	ATPase activity
EHW12_RS14875	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
EHW12_RS14895	COG0488	(ABC) transporter
EHW12_RS14900	COG1309	transcriptional regulator
EHW12_RS14915	COG0791	NLP P60 protein
EHW12_RS14915	COG3883	PFAM NLP P60 protein
EHW12_RS14920	COG0714	Associated with various cellular activities
EHW12_RS14930	COG2304	oxidoreductase activity
EHW12_RS14945	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EHW12_RS14965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EHW12_RS14965	COG1024	Enoyl-CoA hydratase
EHW12_RS15020	COG0730	response to heat
EHW12_RS15045	COG1253	flavin adenine dinucleotide binding
EHW12_RS15050	COG1253	flavin adenine dinucleotide binding
EHW12_RS15065	COG0697	spore germination
EHW12_RS15075	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EHW12_RS15080	COG0513	Belongs to the DEAD box helicase family
EHW12_RS15095	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
EHW12_RS15100	COG1120	ATPase activity
EHW12_RS15105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS15110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS15125	COG1252	NADH dehydrogenase
EHW12_RS15130	COG0640	Transcriptional regulator
EHW12_RS15160	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EHW12_RS15170	COG3300	MHYT domain
EHW12_RS15170	COG5001	Diguanylate cyclase
EHW12_RS15235	COG2197	response regulator
EHW12_RS15240	COG4585	Histidine kinase
EHW12_RS15260	COG1090	epimerase
EHW12_RS15340	COG2205	protein histidine kinase activity
EHW12_RS15355	COG2241	protein methyltransferase activity
EHW12_RS15355	COG2242	protein methyltransferase activity
EHW12_RS15360	COG0300	oxidoreductase activity
EHW12_RS15395	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EHW12_RS15400	COG2378	regulation of single-species biofilm formation
EHW12_RS15410	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EHW12_RS15425	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
EHW12_RS15450	COG1222	aaa ATPase
EHW12_RS15465	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
EHW12_RS15475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EHW12_RS15480	COG0140	phosphoribosyl-ATP diphosphatase activity
EHW12_RS15490	COG1054	Belongs to the UPF0176 family
EHW12_RS15500	COG0646	methionine synthase
EHW12_RS15500	COG1410	methionine synthase
EHW12_RS15540	COG0215	cysteine-tRNA ligase activity
EHW12_RS15545	COG2409	Drug exporters of the RND superfamily
EHW12_RS15570	COG1968	undecaprenyl-diphosphatase activity
EHW12_RS15575	COG0667	Aldo Keto reductase
EHW12_RS15590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS15595	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHW12_RS15615	COG0167	dihydroorotate dehydrogenase activity
EHW12_RS15625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EHW12_RS15650	COG3268	Saccharopine dehydrogenase
EHW12_RS15655	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EHW12_RS15665	COG1408	metallophosphoesterase
EHW12_RS15690	COG1716	ATPase activity
EHW12_RS15735	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS15775	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS15780	COG4608	Belongs to the ABC transporter superfamily
EHW12_RS15785	COG0747	negative chemotaxis
EHW12_RS15795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EHW12_RS15805	COG3328	transposase activity
EHW12_RS15845	COG1160	GTP binding
EHW12_RS15850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
EHW12_RS15860	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EHW12_RS15865	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
EHW12_RS15880	COG0494	nUDIX hydrolase
EHW12_RS15885	COG0504	CTP synthase activity
EHW12_RS15905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EHW12_RS15920	COG0647	UMP catabolic process
EHW12_RS15950	COG2094	Belongs to the DNA glycosylase MPG family
EHW12_RS15955	COG1131	(ABC) transporter
EHW12_RS15970	COG2835	tetraacyldisaccharide 4'-kinase activity
EHW12_RS15980	COG0165	Argininosuccinate lyase
EHW12_RS15985	COG0137	argininosuccinate synthase activity
EHW12_RS15990	COG1438	arginine binding
EHW12_RS15995	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EHW12_RS16005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EHW12_RS16010	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EHW12_RS16025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EHW12_RS16030	COG0385	Bile acid
EHW12_RS16035	COG2072	flavoprotein involved in K transport
EHW12_RS16045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EHW12_RS16045	COG0072	phenylalanine-tRNA ligase activity
EHW12_RS16050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EHW12_RS16060	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EHW12_RS16065	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EHW12_RS16100	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS16145	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
EHW12_RS16145	COG0237	dephospho-CoA kinase activity
EHW12_RS16155	COG0539	negative regulation of cytoplasmic translation
EHW12_RS16160	COG2226	methyltransferase
EHW12_RS16160	COG1073	alpha beta
EHW12_RS16175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EHW12_RS16180	COG0473	3-isopropylmalate dehydrogenase activity
EHW12_RS16200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EHW12_RS16210	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS16250	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EHW12_RS16260	COG1946	Acyl-CoA thioesterase
EHW12_RS16275	COG0069	glutamate synthase activity
EHW12_RS16275	COG0070	glutamate synthase
EHW12_RS16275	COG0067	glutamate synthase
EHW12_RS16290	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EHW12_RS16295	COG0159	tryptophan synthase activity
EHW12_RS16305	COG0134	indole-3-glycerol-phosphate synthase activity
EHW12_RS16315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
EHW12_RS16325	COG3384	dioxygenase
EHW12_RS16335	COG1053	succinate dehydrogenase
EHW12_RS16385	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EHW12_RS16395	COG2124	cytochrome p450
EHW12_RS16440	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS16465	COG1053	succinate dehydrogenase
EHW12_RS16495	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
EHW12_RS16495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EHW12_RS16500	COG3328	transposase activity
EHW12_RS16515	COG2080	2 iron, 2 sulfur cluster binding
EHW12_RS16515	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHW12_RS16530	COG2132	Multicopper oxidase
EHW12_RS16545	COG0640	Transcriptional regulator
EHW12_RS16550	COG0748	coenzyme F420 binding
EHW12_RS16570	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EHW12_RS16580	COG2072	flavoprotein involved in K transport
EHW12_RS16590	COG0107	imidazoleglycerol-phosphate synthase activity
EHW12_RS16595	COG0483	inositol monophosphate 1-phosphatase activity
EHW12_RS16600	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EHW12_RS16610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EHW12_RS16620	COG0131	Imidazoleglycerol-phosphate dehydratase
EHW12_RS16630	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHW12_RS16690	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EHW12_RS16725	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS16730	COG1510	regulation of RNA biosynthetic process
EHW12_RS16740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
EHW12_RS16755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW12_RS16795	COG4221	oxidoreductase activity
EHW12_RS16810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
EHW12_RS16875	COG2199	diguanylate cyclase activity
EHW12_RS16880	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
EHW12_RS16890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
EHW12_RS16905	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS16910	COG3321	synthase
EHW12_RS16910	COG0604	alcohol dehydrogenase
EHW12_RS16910	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS16920	COG1309	transcriptional regulator
EHW12_RS16925	COG5006	permease, DMT superfamily
EHW12_RS16950	COG0477	Major facilitator Superfamily
EHW12_RS16960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHW12_RS16965	COG0798	PFAM Bile acid sodium symporter
EHW12_RS16970	COG0640	Transcriptional regulator
EHW12_RS16990	COG0477	Major facilitator Superfamily
EHW12_RS17005	COG0028	Belongs to the TPP enzyme family
EHW12_RS17040	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHW12_RS17075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EHW12_RS17085	COG3599	regulation of cell shape
EHW12_RS17100	COG1799	cell septum assembly
EHW12_RS17110	COG1496	oxidoreductase activity
EHW12_RS17115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EHW12_RS17120	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EHW12_RS17125	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EHW12_RS17130	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EHW12_RS17140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EHW12_RS17160	COG0768	penicillin binding
EHW12_RS17170	COG0275	rRNA processing
EHW12_RS17175	COG2001	Belongs to the MraZ family
EHW12_RS17215	COG0142	geranyltranstransferase activity
EHW12_RS17250	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
EHW12_RS17265	COG1940	carbohydrate kinase activity
EHW12_RS17275	COG0003	Pfam Anion-transporting ATPase
EHW12_RS17285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW12_RS17310	COG0791	NLP P60 protein
EHW12_RS17325	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EHW12_RS17335	COG1845	cytochrome c oxidase, subunit III
EHW12_RS17355	COG2329	Antibiotic biosynthesis monooxygenase
EHW12_RS17370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
EHW12_RS17380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW12_RS17400	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
EHW12_RS17410	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EHW12_RS17425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
EHW12_RS17430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EHW12_RS17435	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EHW12_RS17455	COG0321	lipoyl(octanoyl) transferase activity
EHW12_RS17460	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHW12_RS17475	COG0174	glutamine synthetase
EHW12_RS17480	COG0582	viral genome integration into host DNA
EHW12_RS17555	COG0305	Participates in initiation and elongation during chromosome replication
EHW12_RS17580	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EHW12_RS17620	COG0740	serine-type endopeptidase activity
EHW12_RS17700	COG5479	isomerase activity
EHW12_RS17700	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS17860	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
EHW12_RS17900	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EHW12_RS17905	COG0174	glutamine synthetase
EHW12_RS17915	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EHW12_RS17950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
EHW12_RS17990	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EHW12_RS18040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW12_RS18045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EHW12_RS18075	COG2197	response regulator
EHW12_RS18080	COG4585	Histidine kinase
EHW12_RS18085	COG2409	Drug exporters of the RND superfamily
EHW12_RS18090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW12_RS18095	COG3842	ATPase activity
EHW12_RS18100	COG0395	ABC-type sugar transport system, permease component
EHW12_RS18120	COG1063	alcohol dehydrogenase
EHW12_RS18170	COG0546	phosphoglycolate phosphatase activity
EHW12_RS18195	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EHW12_RS18210	COG0463	Glycosyl transferase, family 2
EHW12_RS18235	COG0423	glycine-tRNA ligase activity
EHW12_RS18255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHW12_RS18260	COG1381	Involved in DNA repair and RecF pathway recombination
EHW12_RS18285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS18290	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EHW12_RS18315	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EHW12_RS18320	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EHW12_RS18355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EHW12_RS18370	COG0477	Major facilitator Superfamily
EHW12_RS18380	COG1376	ErfK ybiS ycfS ynhG family protein
EHW12_RS18390	COG0484	heat shock protein binding
EHW12_RS18395	COG1420	regulation of RNA biosynthetic process
EHW12_RS18425	COG0175	sulfate reduction
EHW12_RS18455	COG3842	ATPase activity
EHW12_RS18460	COG4208	sulfate ABC transporter
EHW12_RS18480	COG3387	PFAM Glycoside hydrolase 15-related
EHW12_RS18485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS18490	COG2070	2-Nitropropane dioxygenase
EHW12_RS18505	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
EHW12_RS18510	COG1305	Transglutaminase-like
EHW12_RS18525	COG0268	Binds directly to 16S ribosomal RNA
EHW12_RS18550	COG2755	lipolytic protein G-D-S-L family
EHW12_RS18555	COG0406	alpha-ribazole phosphatase activity
EHW12_RS18565	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EHW12_RS18575	COG0542	response to heat
EHW12_RS18580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EHW12_RS18585	COG1902	pentaerythritol trinitrate reductase activity
EHW12_RS18595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EHW12_RS18605	COG0514	ATP-dependent DNA helicase (RecQ)
EHW12_RS18610	COG0456	acetyltransferase
EHW12_RS18615	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EHW12_RS18620	COG1917	Cupin 2, conserved barrel domain protein
EHW12_RS18645	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EHW12_RS18650	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EHW12_RS18655	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EHW12_RS18660	COG1530	ribonuclease E activity
EHW12_RS18660	COG1530	ribonuclease E activity
EHW12_RS18665	COG0105	UTP biosynthetic process
EHW12_RS18675	COG0285	dihydrofolate synthase activity
EHW12_RS18680	COG0525	valine-tRNA ligase activity
EHW12_RS18690	COG1506	peptidase
EHW12_RS18690	COG4946	Tricorn protease homolog
EHW12_RS18690	COG0823	Involved in the tonB-independent uptake of proteins
EHW12_RS18710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EHW12_RS18720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW12_RS18725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EHW12_RS18730	COG1309	transcriptional regulator
EHW12_RS18740	COG0477	Major facilitator Superfamily
EHW12_RS18745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EHW12_RS18750	COG0740	serine-type endopeptidase activity
EHW12_RS18755	COG0740	serine-type endopeptidase activity
EHW12_RS18760	COG0544	peptidyl-prolyl cis-trans isomerase activity
EHW12_RS18795	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
EHW12_RS18810	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
EHW12_RS18850	COG2902	Dehydrogenase
EHW12_RS18865	COG2814	Major facilitator Superfamily
EHW12_RS18890	COG1414	Transcriptional regulator
EHW12_RS18900	COG1309	transcriptional regulator
EHW12_RS18920	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS18925	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS18945	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS18950	COG1053	succinate dehydrogenase
EHW12_RS18955	COG1132	(ABC) transporter
EHW12_RS18960	COG1846	Transcriptional regulator
EHW12_RS18970	COG3336	cytochrome c oxidase
EHW12_RS18985	COG3764	Sortase (surface protein transpeptidase)
EHW12_RS19005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EHW12_RS19035	COG0596	Alpha beta hydrolase
EHW12_RS19055	COG0446	pyridine nucleotide-disulphide oxidoreductase
EHW12_RS19055	COG1902	pentaerythritol trinitrate reductase activity
EHW12_RS19060	COG0300	oxidoreductase activity
EHW12_RS19075	COG0433	COG0433 Predicted ATPase
EHW12_RS19080	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EHW12_RS19090	COG0789	Transcriptional regulator
EHW12_RS19100	COG1376	ErfK ybiS ycfS ynhG family protein
EHW12_RS19140	COG0736	holo-[acyl-carrier-protein] synthase activity
EHW12_RS19175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EHW12_RS19180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
EHW12_RS19185	COG1234	tRNA 3'-trailer cleavage
EHW12_RS19195	COG3191	aminopeptidase activity
EHW12_RS19205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EHW12_RS19210	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EHW12_RS19215	COG1335	isochorismatase
EHW12_RS19225	COG0058	SHG alpha-glucan phosphorylase activity
EHW12_RS19230	COG0366	Alpha amylase catalytic
EHW12_RS19235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
EHW12_RS19255	COG0183	Belongs to the thiolase family
EHW12_RS19275	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
EHW12_RS19305	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EHW12_RS19320	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EHW12_RS19325	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EHW12_RS19330	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EHW12_RS19335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EHW12_RS19340	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHW12_RS19345	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EHW12_RS19350	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EHW12_RS19355	COG0356	it plays a direct role in the translocation of protons across the membrane
EHW12_RS19365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EHW12_RS19370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHW12_RS19380	COG2890	protein-(glutamine-N5) methyltransferase activity
EHW12_RS19385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EHW12_RS19390	COG0254	rRNA binding
EHW12_RS19400	COG0083	homoserine kinase activity
EHW12_RS19405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
EHW12_RS19410	COG0460	homoserine dehydrogenase
EHW12_RS19415	COG0019	diaminopimelate decarboxylase activity
EHW12_RS19420	COG0018	arginyl-trna synthetase
EHW12_RS19435	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
EHW12_RS19450	COG0477	Major facilitator Superfamily
EHW12_RS19470	COG0686	Belongs to the AlaDH PNT family
EHW12_RS19480	COG1218	3'(2'),5'-bisphosphate nucleotidase
EHW12_RS19515	COG0596	Alpha beta hydrolase
EHW12_RS19540	COG2814	Major facilitator Superfamily
EHW12_RS19565	COG1024	Enoyl-CoA hydratase
EHW12_RS19570	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS19585	COG0363	glucosamine-6-phosphate deaminase activity
EHW12_RS19590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EHW12_RS19595	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EHW12_RS19605	COG1263	PTS System
EHW12_RS19610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
EHW12_RS19615	COG2190	(PTS) system
EHW12_RS19620	COG2188	Transcriptional regulator
EHW12_RS19625	COG4279	zinc finger
EHW12_RS19630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW12_RS19635	COG0604	alcohol dehydrogenase
EHW12_RS19635	COG3321	synthase
EHW12_RS19645	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHW12_RS19675	COG0582	viral genome integration into host DNA
EHW12_RS19700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW12_RS19715	COG1280	lysine exporter protein (LysE YggA)
EHW12_RS19725	COG3135	benzoate transporter
EHW12_RS19745	COG0022	dehydrogenase e1 component
EHW12_RS19750	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS19755	COG2223	nitrite transmembrane transporter activity
EHW12_RS19785	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS19820	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
EHW12_RS19820	COG0352	thiamine-phosphate diphosphorylase activity
EHW12_RS19820	COG0351	phosphomethylpyrimidine kinase
EHW12_RS19825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW12_RS19830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS19860	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
EHW12_RS19870	COG1522	sequence-specific DNA binding
EHW12_RS19890	COG3328	transposase activity
EHW12_RS19930	COG1063	alcohol dehydrogenase
EHW12_RS19955	COG1022	Amp-dependent synthetase and ligase
EHW12_RS19965	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHW12_RS20035	COG0210	DNA helicase
EHW12_RS20065	COG2176	DNA-directed DNA polymerase activity
EHW12_RS20100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EHW12_RS20110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS20115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS20125	COG0531	amino acid
EHW12_RS20160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS20165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS20170	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHW12_RS20175	COG1823	symporter activity
EHW12_RS20190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EHW12_RS20240	COG0439	Biotin carboxylase
EHW12_RS20260	COG0667	Aldo Keto reductase
EHW12_RS20285	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS20295	COG0577	efflux transmembrane transporter activity
EHW12_RS20300	COG1136	(ABC) transporter
EHW12_RS20300	COG0577	efflux transmembrane transporter activity
EHW12_RS20310	COG3012	SEC-C Motif Domain Protein
EHW12_RS20320	COG1132	(ABC) transporter
EHW12_RS20330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW12_RS20355	COG0277	FAD linked oxidase domain protein
EHW12_RS20365	COG1335	isochorismatase
EHW12_RS20370	COG2267	carboxylic ester hydrolase activity
EHW12_RS20395	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EHW12_RS20400	COG1024	Enoyl-CoA hydratase
EHW12_RS20405	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS20415	COG0277	FAD linked oxidase domain protein
EHW12_RS20435	COG0435	Glutathione S-transferase
EHW12_RS20450	COG1131	(ABC) transporter
EHW12_RS20460	COG1132	(ABC) transporter
EHW12_RS20465	COG0567	Dehydrogenase, E1 component
EHW12_RS20465	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS20470	COG1309	transcriptional regulator
EHW12_RS20500	COG1125	glycine betaine transport
EHW12_RS20500	COG0517	IMP dehydrogenase activity
EHW12_RS20505	COG1174	glycine betaine transport
EHW12_RS20525	COG2095	MarC family integral membrane protein
EHW12_RS20535	COG0598	Magnesium transport protein CorA
EHW12_RS20600	COG2301	Belongs to the HpcH HpaI aldolase family
EHW12_RS20605	COG2239	Acts as a magnesium transporter
EHW12_RS20635	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW12_RS20640	COG5662	AntiSigma factor
EHW12_RS20655	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
EHW12_RS20660	COG0297	glycogen (starch) synthase activity
EHW12_RS20665	COG2226	methyltransferase
EHW12_RS20675	COG0519	Catalyzes the synthesis of GMP from XMP
EHW12_RS20685	COG0463	Glycosyl transferase, family 2
EHW12_RS20690	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
EHW12_RS20695	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS20700	COG1611	Belongs to the LOG family
EHW12_RS20705	COG1611	Belongs to the LOG family
EHW12_RS20715	COG2171	N-acyltransferase activity
EHW12_RS20720	COG1113	amino acid transport
EHW12_RS20730	COG1131	(ABC) transporter
EHW12_RS20745	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS20770	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
EHW12_RS20800	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHW12_RS20805	COG0747	negative chemotaxis
EHW12_RS20820	COG2154	pterin-4-alpha-carbinolamine dehydratase
EHW12_RS20840	COG2814	Major facilitator Superfamily
EHW12_RS20850	COG3757	hydrolase, family 25
EHW12_RS20865	COG0402	S-adenosylhomocysteine deaminase activity
EHW12_RS20900	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW12_RS20900	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
EHW12_RS20945	COG0584	glycerophosphoryl diester phosphodiesterase
EHW12_RS20960	COG0012	GTP binding
EHW12_RS20970	COG0069	glutamate synthase activity
EHW12_RS20975	COG1966	Carbon starvation protein
EHW12_RS20995	COG0419	ATPase involved in DNA repair
EHW12_RS21000	COG0420	3'-5' exonuclease activity
EHW12_RS21010	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EHW12_RS21020	COG1570	exodeoxyribonuclease VII activity
EHW12_RS21060	COG0477	Major facilitator Superfamily
EHW12_RS21070	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
EHW12_RS21080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EHW12_RS21085	COG2197	response regulator
EHW12_RS21095	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EHW12_RS21105	COG1072	(Pantothenic acid kinase))
EHW12_RS21110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
EHW12_RS21120	COG1331	Highly conserved protein containing a thioredoxin domain
EHW12_RS21130	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
EHW12_RS21140	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EHW12_RS21145	COG0791	NLP P60 protein
EHW12_RS21145	COG3883	PFAM NLP P60 protein
EHW12_RS21160	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EHW12_RS21175	COG2755	lipolytic protein G-D-S-L family
EHW12_RS21180	COG0183	Belongs to the thiolase family
EHW12_RS21185	COG1024	Enoyl-CoA hydratase
EHW12_RS21195	COG2813	Specifically methylates the guanine in position
EHW12_RS21210	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS21260	COG0148	phosphopyruvate hydratase activity
EHW12_RS21270	COG0672	)-iron permease
EHW12_RS21280	COG2837	iron assimilation
EHW12_RS21340	COG3956	TIGRFAM MazG family protein
EHW12_RS21360	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EHW12_RS21370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EHW12_RS21375	COG0736	holo-[acyl-carrier-protein] synthase activity
EHW12_RS21385	COG1309	transcriptional regulator
EHW12_RS21410	COG0490	domain, Protein
EHW12_RS21410	COG0471	metal ion transport
EHW12_RS21420	COG2133	pyrroloquinoline quinone binding
EHW12_RS21445	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHW12_RS21480	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EHW12_RS21485	COG0193	aminoacyl-tRNA hydrolase activity
EHW12_RS21490	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS21495	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EHW12_RS21525	COG1132	(ABC) transporter
EHW12_RS21540	COG2814	Major facilitator Superfamily
EHW12_RS21560	COG1120	ATPase activity
EHW12_RS21565	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS21570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS21590	COG2207	Transcriptional regulator
EHW12_RS21610	COG0488	(ABC) transporter
EHW12_RS21615	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EHW12_RS21625	COG1131	(ABC) transporter
EHW12_RS21640	COG2608	mercury ion transmembrane transporter activity
EHW12_RS21655	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EHW12_RS21660	COG3583	domain protein
EHW12_RS21665	COG3583	domain protein
EHW12_RS21670	COG0765	amino acid transport
EHW12_RS21675	COG1126	abc transporter atp-binding protein
EHW12_RS21690	COG0084	hydrolase, TatD family'
EHW12_RS21715	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
EHW12_RS21720	COG2259	Doxx family
EHW12_RS21735	COG1393	Belongs to the ArsC family
EHW12_RS21740	COG2235	arginine
EHW12_RS21745	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EHW12_RS21800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW12_RS21810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
EHW12_RS21815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EHW12_RS21830	COG1970	mechanosensitive ion channel activity
EHW12_RS21835	COG0521	Mo-molybdopterin cofactor biosynthetic process
EHW12_RS21835	COG0315	cyclic pyranopterin monophosphate synthase activity
EHW12_RS21840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW12_RS21855	COG2860	membrane
EHW12_RS21865	COG0254	rRNA binding
EHW12_RS21875	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EHW12_RS21885	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EHW12_RS21890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHW12_RS21935	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW12_RS21940	COG2957	Belongs to the agmatine deiminase family
EHW12_RS21950	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EHW12_RS21995	COG1739	Uncharacterized protein family UPF0029
EHW12_RS22005	COG0045	succinate-CoA ligase (ADP-forming) activity
EHW12_RS22015	COG0739	heme binding
EHW12_RS22055	COG1131	(ABC) transporter
EHW12_RS22070	COG1252	NADH dehydrogenase
EHW12_RS22080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW12_RS22085	COG2272	Belongs to the type-B carboxylesterase lipase family
EHW12_RS22090	COG2272	Belongs to the type-B carboxylesterase lipase family
EHW12_RS22100	COG1396	sequence-specific DNA binding
EHW12_RS22110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EHW12_RS22135	COG2814	Major facilitator Superfamily
EHW12_RS22140	COG0583	DNA-binding transcription factor activity
EHW12_RS22145	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EHW12_RS22150	COG3706	GGDEF domain
EHW12_RS22165	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EHW12_RS22200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS22220	COG1113	amino acid transport
EHW12_RS22230	COG1070	Carbohydrate kinase
EHW12_RS22245	COG1846	Transcriptional regulator
EHW12_RS22245	COG1940	carbohydrate kinase activity
EHW12_RS22250	COG0477	Major facilitator Superfamily
EHW12_RS22255	COG1024	Enoyl-CoA hydratase
EHW12_RS22270	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS22330	COG0183	Belongs to the thiolase family
EHW12_RS22335	COG0183	Belongs to the thiolase family
EHW12_RS22340	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS22370	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EHW12_RS22375	COG2175	clavaminate synthase activity
EHW12_RS22385	COG3119	arylsulfatase activity
EHW12_RS22395	COG0642	Histidine kinase
EHW12_RS22395	COG3850	Histidine kinase
EHW12_RS22430	COG0477	Major facilitator Superfamily
EHW12_RS22460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHW12_RS22470	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EHW12_RS22480	COG3279	Response regulator of the LytR AlgR family
EHW12_RS22485	COG3275	phosphorelay sensor kinase activity
EHW12_RS22500	COG0025	NhaP-type Na H and K H
EHW12_RS22515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EHW12_RS22530	COG2072	flavoprotein involved in K transport
EHW12_RS22535	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EHW12_RS22550	COG2018	Roadblock/LC7 domain
EHW12_RS22585	COG3634	alkyl hydroperoxide reductase activity
EHW12_RS22595	COG1846	Transcriptional regulator
EHW12_RS22600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW12_RS22610	COG0656	L-ascorbic acid biosynthetic process
EHW12_RS22620	COG0488	(ABC) transporter
EHW12_RS22625	COG0656	L-ascorbic acid biosynthetic process
EHW12_RS22635	COG0346	lactoylglutathione lyase activity
EHW12_RS22655	COG4152	abc transporter atp-binding protein
EHW12_RS22660	COG1668	transmembrane transport
EHW12_RS22705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EHW12_RS22715	COG2814	Major facilitator Superfamily
EHW12_RS22730	COG0415	Belongs to the DNA photolyase family
EHW12_RS22765	COG0659	secondary active sulfate transmembrane transporter activity
EHW12_RS22770	COG0667	Aldo Keto reductase
EHW12_RS22805	COG3284	Transcriptional regulator
EHW12_RS22810	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW12_RS22815	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS22820	COG0022	dehydrogenase e1 component
EHW12_RS22825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EHW12_RS22850	COG0745	RESPONSE REGULATOR receiver
EHW12_RS22855	COG2205	protein histidine kinase activity
EHW12_RS22860	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EHW12_RS22865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EHW12_RS22905	COG2017	converts alpha-aldose to the beta-anomer
EHW12_RS22925	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EHW12_RS22945	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EHW12_RS22970	COG2252	PERMEase
EHW12_RS22980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
EHW12_RS23005	COG2814	Major facilitator Superfamily
EHW12_RS23015	COG1278	Cold shock
EHW12_RS23070	COG1063	alcohol dehydrogenase
EHW12_RS23075	COG1061	Type III restriction enzyme res subunit
EHW12_RS23090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS23100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS23120	COG1595	DNA-templated transcription, initiation
EHW12_RS23125	COG1289	transmembrane transporter activity
EHW12_RS23135	COG1309	transcriptional regulator
EHW12_RS23170	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS23220	COG1522	sequence-specific DNA binding
EHW12_RS23225	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
EHW12_RS23235	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
EHW12_RS23275	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS23280	COG1024	Enoyl-CoA hydratase
EHW12_RS23290	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS23295	COG0583	DNA-binding transcription factor activity
EHW12_RS23300	COG0477	Major facilitator Superfamily
EHW12_RS23305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
EHW12_RS23320	COG0673	inositol 2-dehydrogenase activity
EHW12_RS23335	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EHW12_RS23355	COG4335	DNA alkylation repair
EHW12_RS23370	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS23375	COG0506	proline dehydrogenase activity
EHW12_RS23380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS23395	COG1131	(ABC) transporter
EHW12_RS23405	COG4585	Histidine kinase
EHW12_RS23410	COG2197	response regulator
EHW12_RS23420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW12_RS23430	COG1309	transcriptional regulator
EHW12_RS23460	COG0542	response to heat
EHW12_RS23475	COG2084	Dehydrogenase
EHW12_RS23495	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EHW12_RS23515	COG2197	response regulator
EHW12_RS23555	COG1846	Transcriptional regulator
EHW12_RS23560	COG1764	response to oxidative stress
EHW12_RS23565	COG2130	NADP-dependent
EHW12_RS23610	COG1953	Uracil, thiamine, allantoin
EHW12_RS23620	COG2814	Major facilitator Superfamily
EHW12_RS23625	COG0640	Transcriptional regulator
EHW12_RS23645	COG2072	flavoprotein involved in K transport
EHW12_RS23665	COG4266	Belongs to the allantoicase family
EHW12_RS23680	COG0564	pseudouridine synthase activity
EHW12_RS23690	COG0589	response to stress
EHW12_RS23700	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS23705	COG1309	transcriptional regulator
EHW12_RS23715	COG0477	Major facilitator Superfamily
EHW12_RS23720	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS23760	COG0477	Major facilitator Superfamily
EHW12_RS23780	COG1309	transcriptional regulator
EHW12_RS23820	COG2814	Major facilitator Superfamily
EHW12_RS23825	COG0583	DNA-binding transcription factor activity
EHW12_RS23855	COG0829	nickel cation binding
EHW12_RS23860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EHW12_RS23870	COG0804	urea catabolic process
EHW12_RS23875	COG0832	Belongs to the urease beta subunit family
EHW12_RS23880	COG0831	urea catabolic process
EHW12_RS23885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EHW12_RS23890	COG0581	inorganic phosphate transmembrane transporter activity
EHW12_RS23905	COG0456	acetyltransferase
EHW12_RS23905	COG0454	-acetyltransferase
EHW12_RS23910	COG0745	RESPONSE REGULATOR receiver
EHW12_RS23930	COG2897	thiosulfate sulfurtransferase activity
EHW12_RS23940	COG4044	May play a role in the intracellular transport of hydrophobic ligands
EHW12_RS23950	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
EHW12_RS23960	COG1294	oxidase, subunit
EHW12_RS23965	COG1271	oxidase subunit
EHW12_RS23995	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EHW12_RS24040	COG2837	iron assimilation
EHW12_RS24045	COG1362	aminopeptidase activity
EHW12_RS24065	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS24070	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EHW12_RS24075	COG0135	phosphoribosylanthranilate isomerase activity
EHW12_RS24085	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS24100	COG2130	NADP-dependent
EHW12_RS24115	COG1609	Transcriptional regulator
EHW12_RS24130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS24135	COG0657	acetylesterase activity
EHW12_RS24150	COG2072	flavoprotein involved in K transport
EHW12_RS24185	COG4521	taurine ABC transporter
EHW12_RS24190	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS24210	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EHW12_RS24220	COG2304	oxidoreductase activity
EHW12_RS24225	COG3447	MASE1 domain protein
EHW12_RS24225	COG5002	protein histidine kinase activity
EHW12_RS24225	COG5001	Diguanylate cyclase
EHW12_RS24235	COG1846	Transcriptional regulator
EHW12_RS24265	COG2072	flavoprotein involved in K transport
EHW12_RS24300	COG1983	PspC domain protein
EHW12_RS24310	COG1733	regulation of RNA biosynthetic process
EHW12_RS24315	COG0778	Nitroreductase
EHW12_RS24320	COG1174	glycine betaine transport
EHW12_RS24330	COG1174	glycine betaine transport
EHW12_RS24340	COG4106	trans-aconitate 2-methyltransferase activity
EHW12_RS24360	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS24365	COG1309	transcriptional regulator
EHW12_RS24410	COG0681	Belongs to the peptidase S26 family
EHW12_RS24425	COG1574	metal-dependent hydrolase with the TIM-barrel fold
EHW12_RS24440	COG0488	(ABC) transporter
EHW12_RS24455	COG1053	succinate dehydrogenase
EHW12_RS24465	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS24505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
EHW12_RS24520	COG3590	peptidase
EHW12_RS24525	COG1742	UPF0060 membrane protein
EHW12_RS24530	COG3842	ATPase activity
EHW12_RS24545	COG1175	transmembrane transport
EHW12_RS24550	COG1376	ErfK ybiS ycfS ynhG family protein
EHW12_RS24565	COG3360	Dodecin
EHW12_RS24570	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHW12_RS24585	COG1793	dna ligase
EHW12_RS24595	COG0598	Magnesium transport protein CorA
EHW12_RS24605	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS24620	COG4166	transmembrane transport
EHW12_RS24630	COG0444	Belongs to the ABC transporter superfamily
EHW12_RS24655	COG4948	Mandelate Racemase Muconate Lactonizing
EHW12_RS24675	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS24710	COG1408	metallophosphoesterase
EHW12_RS24720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
EHW12_RS24730	COG0277	FAD linked oxidase domain protein
EHW12_RS24735	COG2318	DinB family
EHW12_RS24740	COG0326	Molecular chaperone. Has ATPase activity
EHW12_RS24745	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS24750	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS24765	COG1846	Transcriptional regulator
EHW12_RS24775	COG1309	transcriptional regulator
EHW12_RS24785	COG3634	alkyl hydroperoxide reductase activity
EHW12_RS24790	COG1846	Transcriptional regulator
EHW12_RS24795	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EHW12_RS24815	COG1063	alcohol dehydrogenase
EHW12_RS24820	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS24825	COG0022	dehydrogenase e1 component
EHW12_RS24830	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
EHW12_RS24840	COG0477	Major facilitator Superfamily
EHW12_RS24850	COG0477	Major facilitator Superfamily
EHW12_RS24860	COG0300	oxidoreductase activity
EHW12_RS24865	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
EHW12_RS24875	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
EHW12_RS24885	COG1396	sequence-specific DNA binding
EHW12_RS24885	COG3800	Transcriptional regulator
EHW12_RS24915	COG2271	Major facilitator Superfamily
EHW12_RS24920	COG0667	Aldo Keto reductase
EHW12_RS24945	COG0129	dihydroxy-acid dehydratase activity
EHW12_RS24960	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
EHW12_RS24970	COG0477	Major facilitator Superfamily
EHW12_RS24980	COG3185	4-Hydroxyphenylpyruvate dioxygenase
EHW12_RS24990	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EHW12_RS25005	COG0583	DNA-binding transcription factor activity
EHW12_RS25015	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25020	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25030	COG2030	dehydratase
EHW12_RS25035	COG0183	Belongs to the thiolase family
EHW12_RS25045	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25055	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25075	COG2011	ABC-type metal ion transport system permease component
EHW12_RS25115	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25120	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS25135	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
EHW12_RS25155	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25165	COG2030	dehydratase
EHW12_RS25170	COG0183	Belongs to the thiolase family
EHW12_RS25175	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25180	COG0183	Belongs to the thiolase family
EHW12_RS25185	COG1309	transcriptional regulator
EHW12_RS25215	COG0640	Transcriptional regulator
EHW12_RS25225	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25250	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25285	COG2902	Dehydrogenase
EHW12_RS25290	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25310	COG2986	histidine ammonia-lyase
EHW12_RS25315	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EHW12_RS25320	COG0277	FAD linked oxidase domain protein
EHW12_RS25325	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHW12_RS25330	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EHW12_RS25335	COG1228	amidohydrolase
EHW12_RS25360	COG0517	IMP dehydrogenase activity
EHW12_RS25360	COG1125	glycine betaine transport
EHW12_RS25365	COG2986	histidine ammonia-lyase
EHW12_RS25380	COG1309	transcriptional regulator
EHW12_RS25395	COG2175	clavaminate synthase activity
EHW12_RS25410	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25425	COG1309	transcriptional regulator
EHW12_RS25430	COG1309	transcriptional regulator
EHW12_RS25470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS25490	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25515	COG0604	alcohol dehydrogenase
EHW12_RS25540	COG0640	Transcriptional regulator
EHW12_RS25545	COG0183	Belongs to the thiolase family
EHW12_RS25555	COG2188	Transcriptional regulator
EHW12_RS25565	COG2301	Belongs to the HpcH HpaI aldolase family
EHW12_RS25575	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS25580	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25585	COG2271	Major facilitator Superfamily
EHW12_RS25590	COG0183	Belongs to the thiolase family
EHW12_RS25600	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25610	COG0583	DNA-binding transcription factor activity
EHW12_RS25615	COG0583	DNA-binding transcription factor activity
EHW12_RS25620	COG1024	Enoyl-CoA hydratase
EHW12_RS25625	COG1024	Enoyl-CoA hydratase
EHW12_RS25630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EHW12_RS25635	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25640	COG0583	DNA-binding transcription factor activity
EHW12_RS25645	COG0583	DNA-binding transcription factor activity
EHW12_RS25655	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25660	COG0183	Belongs to the thiolase family
EHW12_RS25665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS25675	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25680	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS25685	COG1024	Enoyl-CoA hydratase
EHW12_RS25695	COG0653	protein targeting
EHW12_RS25700	COG0653	protein targeting
EHW12_RS25710	COG0028	Belongs to the TPP enzyme family
EHW12_RS25745	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS25765	COG1846	Transcriptional regulator
EHW12_RS25785	COG2409	Drug exporters of the RND superfamily
EHW12_RS25795	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EHW12_RS25800	COG1595	DNA-templated transcription, initiation
EHW12_RS25805	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
EHW12_RS25815	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25825	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS25830	COG1132	(ABC) transporter
EHW12_RS25835	COG1309	transcriptional regulator
EHW12_RS25870	COG2365	Tyrosine phosphatase family
EHW12_RS25875	COG0697	spore germination
EHW12_RS25880	COG1309	transcriptional regulator
EHW12_RS25895	COG1454	alcohol dehydrogenase
EHW12_RS25910	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS25915	COG1879	ABC-type sugar transport system periplasmic component
EHW12_RS25940	COG1027	Aspartate ammonia-lyase
EHW12_RS25945	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EHW12_RS25950	COG0673	inositol 2-dehydrogenase activity
EHW12_RS25985	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS25990	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS26005	COG0277	FAD linked oxidase domain protein
EHW12_RS26010	COG4941	Belongs to the sigma-70 factor family
EHW12_RS26015	COG3795	YCII-related domain
EHW12_RS26030	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS26035	COG1556	Lactate utilization protein
EHW12_RS26040	COG1139	Iron-sulfur cluster binding protein
EHW12_RS26045	COG0247	lactate metabolic process
EHW12_RS26050	COG1802	Transcriptional regulator
EHW12_RS26075	COG1172	Belongs to the binding-protein-dependent transport system permease family
EHW12_RS26100	COG1609	Transcriptional regulator
EHW12_RS26125	COG3708	Transcriptional regulator
EHW12_RS26125	COG2207	Transcriptional regulator
EHW12_RS26140	COG3485	protocatechuate 3,4-dioxygenase
EHW12_RS26145	COG3485	protocatechuate 3,4-dioxygenase
EHW12_RS26150	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
EHW12_RS26155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EHW12_RS26160	COG1414	Transcriptional regulator
EHW12_RS26190	COG1278	Cold shock
EHW12_RS26225	COG0668	transmembrane transport
EHW12_RS26230	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
EHW12_RS26235	COG0590	tRNA wobble adenosine to inosine editing
EHW12_RS26260	COG2267	carboxylic ester hydrolase activity
EHW12_RS26270	COG1305	Transglutaminase-like
EHW12_RS26275	COG0657	acetylesterase activity
EHW12_RS26290	COG3265	gluconokinase activity
EHW12_RS26300	COG2186	Transcriptional regulator
EHW12_RS26305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EHW12_RS26310	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS26340	COG2030	dehydratase
EHW12_RS26350	COG2267	carboxylic ester hydrolase activity
EHW12_RS26405	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS26425	COG3119	arylsulfatase activity
EHW12_RS26435	COG0531	amino acid
EHW12_RS26440	COG0488	(ABC) transporter
EHW12_RS26465	COG2267	carboxylic ester hydrolase activity
EHW12_RS26485	COG1725	Transcriptional regulator
EHW12_RS26495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS26500	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EHW12_RS26505	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
EHW12_RS26525	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EHW12_RS26540	COG2132	Multicopper oxidase
EHW12_RS26565	COG1132	(ABC) transporter
EHW12_RS26580	COG2132	Multicopper oxidase
EHW12_RS26630	COG3467	pyridoxamine 5'-phosphate
EHW12_RS26665	COG1959	2 iron, 2 sulfur cluster binding
EHW12_RS26670	COG3706	GGDEF domain
EHW12_RS26680	COG1063	alcohol dehydrogenase
EHW12_RS26700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EHW12_RS26745	COG2807	transmembrane transport
EHW12_RS26750	COG3145	DNA-N1-methyladenine dioxygenase activity
EHW12_RS26755	COG0640	Transcriptional regulator
EHW12_RS26785	COG0477	Major facilitator Superfamily
EHW12_RS26800	COG3835	regulator
EHW12_RS26825	COG2197	response regulator
EHW12_RS26845	COG4829	muconolactone delta-isomerase
EHW12_RS26850	COG4948	Mandelate Racemase Muconate Lactonizing
EHW12_RS26855	COG3485	protocatechuate 3,4-dioxygenase
EHW12_RS26860	COG1414	Transcriptional regulator
EHW12_RS26895	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS26905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHW12_RS26910	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
EHW12_RS26915	COG0174	glutamine synthetase
EHW12_RS26950	COG2223	nitrite transmembrane transporter activity
EHW12_RS26955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS26985	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS26990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHW12_RS27020	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW12_RS27045	COG0833	amino acid
EHW12_RS27055	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EHW12_RS27060	COG1522	sequence-specific DNA binding
EHW12_RS27090	COG0519	Catalyzes the synthesis of GMP from XMP
EHW12_RS27090	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EHW12_RS27110	COG0640	Transcriptional regulator
EHW12_RS27135	COG0183	Belongs to the thiolase family
EHW12_RS27145	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS27150	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS27165	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS27175	COG1024	Enoyl-CoA hydratase
EHW12_RS27180	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS27195	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS27220	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS27235	COG1802	Transcriptional regulator
EHW12_RS27240	COG1119	ATPase activity
EHW12_RS27260	COG5001	Diguanylate cyclase
EHW12_RS27260	COG3300	MHYT domain
EHW12_RS27265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
EHW12_RS27280	COG1802	Transcriptional regulator
EHW12_RS27355	COG3835	regulator
EHW12_RS27365	COG2814	Major facilitator Superfamily
EHW12_RS27385	COG1053	succinate dehydrogenase
EHW12_RS27395	COG0471	metal ion transport
EHW12_RS27430	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
EHW12_RS27435	COG1959	2 iron, 2 sulfur cluster binding
EHW12_RS27440	COG1017	nitric oxide dioxygenase activity
EHW12_RS27440	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHW12_RS27455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EHW12_RS27460	COG2151	metal-sulfur cluster biosynthetic enzyme
EHW12_RS27465	COG3396	Phenylacetate-CoA oxygenase
EHW12_RS27470	COG3460	Phenylacetate-CoA oxygenase
EHW12_RS27475	COG3396	Phenylacetate-CoA oxygenase
EHW12_RS27480	COG1024	Enoyl-CoA hydratase
EHW12_RS27485	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHW12_RS27490	COG1024	Enoyl-CoA hydratase
EHW12_RS27500	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS27500	COG2030	dehydratase
EHW12_RS27510	COG2050	protein possibly involved in aromatic compounds catabolism
EHW12_RS27510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
EHW12_RS27515	COG3458	cephalosporin-C deacetylase activity
EHW12_RS27540	COG0596	Alpha beta hydrolase
EHW12_RS27550	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS27560	COG1113	amino acid transport
EHW12_RS27565	COG2199	diguanylate cyclase activity
EHW12_RS27570	COG5001	Diguanylate cyclase
EHW12_RS27575	COG0477	Major facilitator Superfamily
EHW12_RS27580	COG3552	Protein containing von Willebrand factor type A (VWA) domain
EHW12_RS27595	COG0714	Associated with various cellular activities
EHW12_RS27630	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS27665	COG1252	NADH dehydrogenase
EHW12_RS27670	COG0583	DNA-binding transcription factor activity
EHW12_RS27680	COG0477	Major facilitator Superfamily
EHW12_RS27690	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS27705	COG0657	acetylesterase activity
EHW12_RS27720	COG2124	cytochrome p450
EHW12_RS27725	COG2130	NADP-dependent
EHW12_RS27745	COG4221	oxidoreductase activity
EHW12_RS27760	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS27765	COG1024	Enoyl-CoA hydratase
EHW12_RS27775	COG1072	(Pantothenic acid kinase))
EHW12_RS27800	COG1609	Transcriptional regulator
EHW12_RS27815	COG0477	Major facilitator Superfamily
EHW12_RS27830	COG2186	Transcriptional regulator
EHW12_RS27835	COG2226	methyltransferase
EHW12_RS27840	COG1607	acyl-coa hydrolase
EHW12_RS27885	COG2376	Dihydroxyacetone kinase
EHW12_RS27905	COG0183	Belongs to the thiolase family
EHW12_RS27910	COG0515	serine threonine protein kinase
EHW12_RS27935	COG4221	oxidoreductase activity
EHW12_RS27955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EHW12_RS27965	COG1917	Cupin 2, conserved barrel domain protein
EHW12_RS27965	COG4977	sequence-specific DNA binding
EHW12_RS27975	COG2186	Transcriptional regulator
EHW12_RS27995	COG2909	trisaccharide binding
EHW12_RS28110	COG2267	carboxylic ester hydrolase activity
EHW12_RS28125	COG1309	transcriptional regulator
EHW12_RS28130	COG1250	3-hydroxyacyl-CoA dehydrogenase
EHW12_RS28145	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
EHW12_RS28155	COG1132	(ABC) transporter
EHW12_RS28160	COG1132	(ABC) transporter
EHW12_RS28165	COG0183	Belongs to the thiolase family
EHW12_RS28185	COG2207	Transcriptional regulator
EHW12_RS28190	COG2957	Belongs to the agmatine deiminase family
EHW12_RS28220	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS28230	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS28250	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
EHW12_RS28265	COG3511	phospholipase C
EHW12_RS28275	COG0657	acetylesterase activity
EHW12_RS28280	COG1733	regulation of RNA biosynthetic process
EHW12_RS28310	COG2146	nitrite reductase [NAD(P)H] activity
EHW12_RS28310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EHW12_RS28325	COG0596	Alpha beta hydrolase
EHW12_RS28330	COG3903	Transcriptional regulator
EHW12_RS28330	COG3629	intracellular signal transduction
EHW12_RS28335	COG2272	Belongs to the type-B carboxylesterase lipase family
EHW12_RS28350	COG0745	RESPONSE REGULATOR receiver
EHW12_RS28370	COG1597	lipid kinase activity
EHW12_RS28385	COG1309	transcriptional regulator
EHW12_RS28400	COG1309	transcriptional regulator
EHW12_RS28405	COG2267	carboxylic ester hydrolase activity
EHW12_RS28435	COG4941	Belongs to the sigma-70 factor family
EHW12_RS28470	COG0406	alpha-ribazole phosphatase activity
EHW12_RS28485	COG1120	ATPase activity
EHW12_RS28490	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS28495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EHW12_RS28500	COG4592	Periplasmic binding protein
EHW12_RS28530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EHW12_RS28560	COG1058	Belongs to the CinA family
EHW12_RS28560	COG1546	Belongs to the CinA family
EHW12_RS28595	COG3973	AAA domain
EHW12_RS28610	COG4569	acetaldehyde dehydrogenase (acetylating) activity
EHW12_RS28615	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EHW12_RS28630	COG2318	DinB family
EHW12_RS28650	COG0789	Transcriptional regulator
EHW12_RS28695	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS28710	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS28725	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS28755	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS28770	COG0477	Major facilitator Superfamily
EHW12_RS28775	COG0583	DNA-binding transcription factor activity
EHW12_RS28795	COG2226	methyltransferase
EHW12_RS28815	COG1846	Transcriptional regulator
EHW12_RS28820	COG0154	amidase activity
EHW12_RS28845	COG0583	DNA-binding transcription factor activity
EHW12_RS28855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS28875	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS28895	COG1309	transcriptional regulator
EHW12_RS28900	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS28905	COG2072	flavoprotein involved in K transport
EHW12_RS28910	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS28945	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EHW12_RS28955	COG1063	alcohol dehydrogenase
EHW12_RS28970	COG0443	Heat shock 70 kDa protein
EHW12_RS28975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHW12_RS28990	COG0542	response to heat
EHW12_RS29005	COG0492	ferredoxin-NADP+ reductase activity
EHW12_RS29030	COG0359	binds to the 23S rRNA
EHW12_RS29035	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EHW12_RS29045	COG0360	Binds together with S18 to 16S ribosomal RNA
EHW12_RS29070	COG4249	Peptidase C14 caspase catalytic subunit p20
EHW12_RS29070	COG2319	Wd-40 repeat
EHW12_RS29085	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHW12_RS29115	COG1260	myo-inositol-1-phosphate synthase
EHW12_RS29130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EHW12_RS29145	COG0330	HflC and HflK could
EHW12_RS29155	COG1414	Transcriptional regulator
EHW12_RS29165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS29170	COG1116	anion transmembrane transporter activity
EHW12_RS29180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS29185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS29195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW12_RS29205	COG0251	oxidation-reduction process
EHW12_RS29210	COG2267	carboxylic ester hydrolase activity
EHW12_RS29220	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW12_RS29225	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS29230	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EHW12_RS29235	COG1116	anion transmembrane transporter activity
EHW12_RS29235	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EHW12_RS29250	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
EHW12_RS29280	COG2233	PERMEase
EHW12_RS29300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EHW12_RS29305	COG2508	Transcriptional regulator
EHW12_RS29320	COG2233	PERMEase
EHW12_RS29330	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EHW12_RS29330	COG3608	succinylglutamate desuccinylase aspartoacylase
EHW12_RS29360	COG0154	amidase activity
EHW12_RS29380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EHW12_RS29405	COG3842	ATPase activity
EHW12_RS29425	COG0740	serine-type endopeptidase activity
EHW12_RS29430	COG0740	serine-type endopeptidase activity
EHW12_RS29440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS29445	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS29450	COG0477	Major facilitator Superfamily
EHW12_RS29455	COG0583	DNA-binding transcription factor activity
EHW12_RS29460	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS29470	COG1309	transcriptional regulator
EHW12_RS29520	COG0765	amino acid transport
EHW12_RS29525	COG1126	abc transporter atp-binding protein
EHW12_RS29530	COG4941	Belongs to the sigma-70 factor family
EHW12_RS29535	COG3795	YCII-related domain
EHW12_RS29540	COG2197	response regulator
EHW12_RS29555	COG1131	(ABC) transporter
EHW12_RS29580	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
EHW12_RS29600	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
EHW12_RS29600	COG1796	DNA polymerase
EHW12_RS29620	COG1108	ABC-type Mn2 Zn2 transport systems permease components
EHW12_RS29625	COG1121	(ABC) transporter
EHW12_RS29655	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EHW12_RS29660	COG0508	dehydrogenase complex catalyzes the overall conversion of
EHW12_RS29675	COG1522	sequence-specific DNA binding
EHW12_RS29680	COG3220	belongs to the UPF0276 family
EHW12_RS29695	COG2837	iron assimilation
EHW12_RS29705	COG2267	carboxylic ester hydrolase activity
EHW12_RS29710	COG3631	Ketosteroid isomerase-related protein
EHW12_RS29730	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EHW12_RS29735	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS29755	COG0477	Major facilitator Superfamily
EHW12_RS29760	COG0495	leucyl-tRNA aminoacylation
EHW12_RS29775	COG2186	Transcriptional regulator
EHW12_RS29780	COG2814	Major facilitator Superfamily
EHW12_RS29795	COG1678	Uncharacterized ACR, COG1678
EHW12_RS29815	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS29825	COG0617	tRNA 3'-terminal CCA addition
EHW12_RS29845	COG1595	DNA-templated transcription, initiation
EHW12_RS29875	COG0860	N-Acetylmuramoyl-L-alanine amidase
EHW12_RS29875	COG3409	Peptidoglycan-binding domain 1 protein
EHW12_RS29890	COG1192	Involved in chromosome partitioning
EHW12_RS29895	COG0357	Ribosomal RNA small subunit methyltransferase G
EHW12_RS29920	COG0706	membrane insertase activity
EHW12_RS29925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EHW12_RS29930	COG0594	ribonuclease P activity
EHW12_RS29935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EHW12_RS29990	COG4221	oxidoreductase activity
EHW12_RS30005	COG0477	Major facilitator Superfamily
EHW12_RS30135	COG2184	nucleotidyltransferase activity
EHW12_RS30155	COG0183	Belongs to the thiolase family
EHW12_RS30160	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS30165	COG1024	Enoyl-CoA hydratase
EHW12_RS30170	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS30175	COG1024	Enoyl-CoA hydratase
EHW12_RS30185	COG2030	dehydratase
EHW12_RS30190	COG0183	Belongs to the thiolase family
EHW12_RS30235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
EHW12_RS30390	COG3547	Transposase (IS116 IS110 IS902 family)
EHW12_RS30420	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHW12_RS30490	COG0739	heme binding
EHW12_RS30490	COG1196	nuclear chromosome segregation
EHW12_RS30490	COG0741	lytic transglycosylase activity
EHW12_RS30585	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
EHW12_RS30590	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
EHW12_RS30660	COG2135	peptidase activity
EHW12_RS30680	COG0582	viral genome integration into host DNA
EHW12_RS30745	COG2176	DNA-directed DNA polymerase activity
EHW12_RS30880	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
EHW12_RS30890	COG0419	ATPase involved in DNA repair
EHW12_RS30910	COG0433	COG0433 Predicted ATPase
EHW12_RS30930	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
EHW12_RS30940	COG0358	DNA primase activity
EHW12_RS31190	COG0714	Associated with various cellular activities
EHW12_RS31220	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EHW12_RS31475	COG1192	Involved in chromosome partitioning
EHW12_RS31565	COG3328	transposase activity
EHW12_RS31595	COG3328	transposase activity
EHW12_RS31610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHW12_RS31620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHW12_RS31625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EHW12_RS31630	COG0798	PFAM Bile acid sodium symporter
EHW12_RS31635	COG0640	Transcriptional regulator
EHW12_RS31655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHW12_RS31675	COG0456	acetyltransferase
EHW12_RS31690	COG2072	flavoprotein involved in K transport
EHW12_RS31705	COG2801	Transposase and inactivated derivatives
EHW12_RS31710	COG2826	transposase and inactivated derivatives, IS30 family
EHW12_RS31745	COG2205	protein histidine kinase activity
EHW12_RS31750	COG0745	RESPONSE REGULATOR receiver
EHW12_RS31775	COG2217	Heavy metal translocating P-type atpase
EHW12_RS31835	COG3328	transposase activity
EHW12_RS31860	COG0791	NLP P60 protein
EHW12_RS31860	COG3883	PFAM NLP P60 protein
EHW12_RS31875	COG0640	Transcriptional regulator
EHW12_RS31900	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EHW12_RS31910	COG0789	Transcriptional regulator
EHW12_RS31935	COG0785	Cytochrome C biogenesis protein
EHW12_RS31970	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHW12_RS31970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHW12_RS31990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
EHW12_RS32005	COG0739	heme binding
EHW12_RS32020	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EHW12_RS32180	COG2135	peptidase activity
EHW12_RS32190	COG0789	Transcriptional regulator
EHW12_RS32295	COG0175	sulfate reduction
EHW12_RS32305	COG0791	NLP P60 protein
EHW12_RS32305	COG3883	PFAM NLP P60 protein
EHW12_RS32350	COG0582	viral genome integration into host DNA
EHW12_RS32420	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EHW12_RS32450	COG2267	carboxylic ester hydrolase activity
EHW12_RS32525	COG3328	transposase activity
EHW12_RS32765	COG1192	Involved in chromosome partitioning
EHW12_RS32820	COG3328	transposase activity
EHW12_RS32825	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS32845	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS32850	COG1414	Transcriptional regulator
EHW12_RS32865	COG1942	4-Oxalocrotonate Tautomerase
EHW12_RS32895	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS32905	COG1063	alcohol dehydrogenase
EHW12_RS32915	COG3328	transposase activity
EHW12_RS32950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW12_RS32960	COG2072	flavoprotein involved in K transport
EHW12_RS32980	COG3328	transposase activity
EHW12_RS33035	COG0288	reversible hydration of carbon dioxide
EHW12_RS33040	COG1573	uracil-dna glycosylase
EHW12_RS33145	COG3328	transposase activity
EHW12_RS33150	COG2026	Addiction module toxin, RelE StbE family
EHW12_RS33155	COG2161	toxin-antitoxin pair type II binding
EHW12_RS33165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EHW12_RS33200	COG0310	cobalt ion transport
EHW12_RS33225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHW12_RS33245	COG2826	transposase and inactivated derivatives, IS30 family
EHW12_RS33250	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHW12_RS33265	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS33275	COG1024	Enoyl-CoA hydratase
EHW12_RS33280	COG4214	carbohydrate transport
EHW12_RS33290	COG1129	ABC transporter
EHW12_RS33295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EHW12_RS33300	COG1024	Enoyl-CoA hydratase
EHW12_RS33310	COG1028	Short-chain dehydrogenase reductase Sdr
EHW12_RS33320	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS33375	COG2826	transposase and inactivated derivatives, IS30 family
EHW12_RS33395	COG3328	transposase activity
EHW12_RS33465	COG1595	DNA-templated transcription, initiation
EHW12_RS33470	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EHW12_RS33495	COG3328	transposase activity
EHW12_RS33500	COG2826	transposase and inactivated derivatives, IS30 family
EHW12_RS33530	COG3328	transposase activity
EHW12_RS33545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EHW12_RS33545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EHW12_RS33570	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
EHW12_RS33585	COG0789	Transcriptional regulator
EHW12_RS33605	COG1295	ribonuclease BN
EHW12_RS33680	COG2337	Toxic component of a toxin-antitoxin (TA) module
EHW12_RS33725	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EHW12_RS33735	COG0443	Heat shock 70 kDa protein
EHW12_RS33740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EHW12_RS33755	COG0542	response to heat
EHW12_RS33765	COG3634	alkyl hydroperoxide reductase activity
EHW12_RS33875	COG3328	transposase activity
EHW12_RS33910	COG0789	Transcriptional regulator
EHW12_RS33995	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EHW12_RS34000	COG1024	Enoyl-CoA hydratase
EHW12_RS34055	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS34070	COG1024	Enoyl-CoA hydratase
EHW12_RS34075	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS34080	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS34085	COG0318	PFAM AMP-dependent synthetase and ligase
EHW12_RS34095	COG1309	transcriptional regulator
EHW12_RS34100	COG2072	flavoprotein involved in K transport
EHW12_RS34115	COG2801	Transposase and inactivated derivatives
EHW12_RS34120	COG2801	Transposase and inactivated derivatives
EHW12_RS34125	COG3547	Transposase (IS116 IS110 IS902 family)
EHW12_RS34135	COG3547	Transposase (IS116 IS110 IS902 family)
EHW12_RS34145	COG1335	isochorismatase
EHW12_RS34160	COG0477	Major facilitator Superfamily
EHW12_RS34175	COG3384	dioxygenase
EHW12_RS34215	COG0583	DNA-binding transcription factor activity
EHW12_RS34230	COG1012	belongs to the aldehyde dehydrogenase family
EHW12_RS34310	COG1278	Cold shock
EHW12_RS34365	COG0765	amino acid transport
EHW12_RS34370	COG1126	abc transporter atp-binding protein
EHW12_RS34375	COG1960	acyl-CoA dehydrogenase activity
EHW12_RS34390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EHW12_RS34405	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EHW12_RS34440	COG0179	Fumarylacetoacetate (FAA) hydrolase
EHW12_RS34450	COG1946	Acyl-CoA thioesterase
EHW12_RS34455	COG3483	tryptophan 2,3-dioxygenase activity
EHW12_RS34470	COG0686	Belongs to the AlaDH PNT family