locus-tag	class	description
G4H71_RS00005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4H71_RS00010	COG2094	Belongs to the DNA glycosylase MPG family
G4H71_RS00030	COG2835	tetraacyldisaccharide 4'-kinase activity
G4H71_RS00040	COG0165	Argininosuccinate lyase
G4H71_RS00045	COG0137	argininosuccinate synthase activity
G4H71_RS00050	COG1438	arginine binding
G4H71_RS00055	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4H71_RS00070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4H71_RS00075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
G4H71_RS00090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS00095	COG4521	taurine ABC transporter
G4H71_RS00105	COG2175	clavaminate synthase activity
G4H71_RS00115	COG0701	Predicted permease
G4H71_RS00125	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4H71_RS00140	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4H71_RS00150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4H71_RS00155	COG1121	(ABC) transporter
G4H71_RS00170	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4H71_RS00180	COG0072	phenylalanine-tRNA ligase activity
G4H71_RS00180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4H71_RS00185	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4H71_RS00230	COG0326	Molecular chaperone. Has ATPase activity
G4H71_RS00250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4H71_RS00280	COG0237	dephospho-CoA kinase activity
G4H71_RS00280	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
G4H71_RS00290	COG0539	negative regulation of cytoplasmic translation
G4H71_RS00295	COG2226	methyltransferase
G4H71_RS00315	COG0473	3-isopropylmalate dehydrogenase activity
G4H71_RS00330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4H71_RS00340	COG1172	Belongs to the binding-protein-dependent transport system permease family
G4H71_RS00390	COG3639	organic phosphonate transmembrane transporter activity
G4H71_RS00395	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4H71_RS00445	COG1946	Acyl-CoA thioesterase
G4H71_RS00460	COG0069	glutamate synthase activity
G4H71_RS00460	COG0070	glutamate synthase
G4H71_RS00460	COG0067	glutamate synthase
G4H71_RS00470	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4H71_RS00475	COG0159	tryptophan synthase activity
G4H71_RS00485	COG0134	indole-3-glycerol-phosphate synthase activity
G4H71_RS00505	COG3384	dioxygenase
G4H71_RS00520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4H71_RS00525	COG0107	imidazoleglycerol-phosphate synthase activity
G4H71_RS00530	COG0483	inositol monophosphate 1-phosphatase activity
G4H71_RS00535	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G4H71_RS00545	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4H71_RS00570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4H71_RS00600	COG0583	DNA-binding transcription factor activity
G4H71_RS00615	COG2015	COG2015, Alkyl sulfatase and related hydrolases
G4H71_RS00640	COG0157	Belongs to the NadC ModD family
G4H71_RS00670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4H71_RS00690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
G4H71_RS00695	COG0156	8-amino-7-oxononanoate synthase activity
G4H71_RS00700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4H71_RS00745	COG0028	Belongs to the TPP enzyme family
G4H71_RS00775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4H71_RS00800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4H71_RS00810	COG3599	regulation of cell shape
G4H71_RS00820	COG1799	cell septum assembly
G4H71_RS00835	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4H71_RS00840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
G4H71_RS00845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4H71_RS00860	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4H71_RS00880	COG0768	penicillin binding
G4H71_RS00890	COG0275	rRNA processing
G4H71_RS00930	COG0142	geranyltranstransferase activity
G4H71_RS00960	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G4H71_RS00980	COG1940	carbohydrate kinase activity
G4H71_RS00990	COG0003	Pfam Anion-transporting ATPase
G4H71_RS01040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4H71_RS01050	COG1845	cytochrome c oxidase, subunit III
G4H71_RS01075	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
G4H71_RS01085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4H71_RS01105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G4H71_RS01110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G4H71_RS01115	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4H71_RS01120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
G4H71_RS01125	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G4H71_RS01140	COG1090	epimerase
G4H71_RS01145	COG0321	lipoyl(octanoyl) transferase activity
G4H71_RS01150	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
G4H71_RS01165	COG0174	glutamine synthetase
G4H71_RS01180	COG1174	glycine betaine transport
G4H71_RS01190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4H71_RS01195	COG0174	glutamine synthetase
G4H71_RS01205	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4H71_RS01295	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
G4H71_RS01310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4H71_RS01315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4H71_RS01365	COG1832	CoA-binding protein
G4H71_RS01380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4H71_RS01390	COG0747	negative chemotaxis
G4H71_RS01465	COG0358	DNA primase activity
G4H71_RS01475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4H71_RS01490	COG0423	glycine-tRNA ligase activity
G4H71_RS01515	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4H71_RS01520	COG1381	Involved in DNA repair and RecF pathway recombination
G4H71_RS01530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS01540	COG0596	Alpha beta hydrolase
G4H71_RS01590	COG0484	heat shock protein binding
G4H71_RS01635	COG0589	response to stress
G4H71_RS01650	COG4208	sulfate ABC transporter
G4H71_RS01660	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
G4H71_RS01675	COG2070	2-Nitropropane dioxygenase
G4H71_RS01680	COG0481	GTPase activity
G4H71_RS01700	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
G4H71_RS01705	COG1305	Transglutaminase-like
G4H71_RS01715	COG2308	Evidence 4 Homologs of previously reported genes of
G4H71_RS01720	COG0268	Binds directly to 16S ribosomal RNA
G4H71_RS01765	COG2755	lipolytic protein G-D-S-L family
G4H71_RS01770	COG0406	alpha-ribazole phosphatase activity
G4H71_RS01775	COG0799	negative regulation of ribosome biogenesis
G4H71_RS01780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4H71_RS01790	COG0542	response to heat
G4H71_RS01795	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4H71_RS01800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4H71_RS01805	COG0514	ATP-dependent DNA helicase (RecQ)
G4H71_RS01810	COG0456	acetyltransferase
G4H71_RS01815	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4H71_RS01820	COG1917	Cupin 2, conserved barrel domain protein
G4H71_RS01825	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4H71_RS01840	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4H71_RS01845	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4H71_RS01855	COG1530	ribonuclease E activity
G4H71_RS01855	COG1530	ribonuclease E activity
G4H71_RS01860	COG0105	UTP biosynthetic process
G4H71_RS01870	COG0285	dihydrofolate synthase activity
G4H71_RS01875	COG0525	valine-tRNA ligase activity
G4H71_RS01890	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G4H71_RS01900	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G4H71_RS01910	COG0740	serine-type endopeptidase activity
G4H71_RS01915	COG0740	serine-type endopeptidase activity
G4H71_RS01920	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4H71_RS01945	COG0477	Major facilitator Superfamily
G4H71_RS01970	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G4H71_RS01985	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G4H71_RS01995	COG0640	Transcriptional regulator
G4H71_RS02010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G4H71_RS02030	COG0366	Alpha amylase catalytic
G4H71_RS02045	COG2902	Dehydrogenase
G4H71_RS02060	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4H71_RS02070	COG3336	cytochrome c oxidase
G4H71_RS02080	COG2130	NADP-dependent
G4H71_RS02085	COG0702	epimerase
G4H71_RS02090	COG2207	Transcriptional regulator
G4H71_RS02095	COG1309	transcriptional regulator
G4H71_RS02100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
G4H71_RS02130	COG2207	Transcriptional regulator
G4H71_RS02140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4H71_RS02165	COG0596	Alpha beta hydrolase
G4H71_RS02170	COG2270	Major facilitator Superfamily
G4H71_RS02175	COG1695	Transcriptional regulator
G4H71_RS02180	COG1902	pentaerythritol trinitrate reductase activity
G4H71_RS02180	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS02185	COG0300	oxidoreductase activity
G4H71_RS02190	COG0433	COG0433 Predicted ATPase
G4H71_RS02195	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
G4H71_RS02210	COG1131	(ABC) transporter
G4H71_RS02220	COG1309	transcriptional regulator
G4H71_RS02225	COG1376	ErfK ybiS ycfS ynhG family protein
G4H71_RS02265	COG0736	holo-[acyl-carrier-protein] synthase activity
G4H71_RS02295	COG1566	PFAM secretion protein HlyD family protein
G4H71_RS02305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4H71_RS02310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4H71_RS02315	COG1234	tRNA 3'-trailer cleavage
G4H71_RS02355	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
G4H71_RS02360	COG1335	isochorismatase
G4H71_RS02370	COG1131	(ABC) transporter
G4H71_RS02375	COG3559	Exporter of polyketide antibiotics
G4H71_RS02380	COG0058	SHG alpha-glucan phosphorylase activity
G4H71_RS02385	COG0366	Alpha amylase catalytic
G4H71_RS02390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
G4H71_RS02410	COG0183	Belongs to the thiolase family
G4H71_RS02415	COG0346	lactoylglutathione lyase activity
G4H71_RS02465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4H71_RS02485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4H71_RS02490	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4H71_RS02500	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4H71_RS02505	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4H71_RS02510	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4H71_RS02515	COG0356	it plays a direct role in the translocation of protons across the membrane
G4H71_RS02525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4H71_RS02535	COG2890	protein-(glutamine-N5) methyltransferase activity
G4H71_RS02540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4H71_RS02545	COG0254	rRNA binding
G4H71_RS02560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G4H71_RS02565	COG0460	homoserine dehydrogenase
G4H71_RS02570	COG0019	diaminopimelate decarboxylase activity
G4H71_RS02590	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
G4H71_RS02600	COG2357	RelA SpoT domain protein
G4H71_RS02605	COG1218	3'(2'),5'-bisphosphate nucleotidase
G4H71_RS02645	COG2855	membrane
G4H71_RS02675	COG1024	Enoyl-CoA hydratase
G4H71_RS02680	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS02695	COG4279	zinc finger
G4H71_RS02700	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4H71_RS02715	COG1132	(ABC) transporter
G4H71_RS02715	COG2375	cellular response to nickel ion
G4H71_RS02755	COG3189	MarR family transcriptional regulator
G4H71_RS02775	COG2272	Belongs to the type-B carboxylesterase lipase family
G4H71_RS02780	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
G4H71_RS02780	COG0351	phosphomethylpyrimidine kinase
G4H71_RS02780	COG0352	thiamine-phosphate diphosphorylase activity
G4H71_RS02785	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4H71_RS02790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS02800	COG0657	acetylesterase activity
G4H71_RS02840	COG1053	succinate dehydrogenase
G4H71_RS02850	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS02855	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS02900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4H71_RS02920	COG0247	lactate metabolic process
G4H71_RS02920	COG0277	FAD linked oxidase domain protein
G4H71_RS02925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
G4H71_RS02950	COG2318	DinB family
G4H71_RS02955	COG0067	glutamate synthase
G4H71_RS02955	COG0069	glutamate synthase activity
G4H71_RS02955	COG0070	glutamate synthase
G4H71_RS02960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4H71_RS02980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
G4H71_RS03015	COG2814	Major facilitator Superfamily
G4H71_RS03025	COG3835	regulator
G4H71_RS03055	COG0601	transmembrane transport
G4H71_RS03060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4H71_RS03065	COG4172	Belongs to the ABC transporter superfamily
G4H71_RS03070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS03110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS03115	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS03120	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS03160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4H71_RS03205	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4H71_RS03205	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4H71_RS03215	COG1823	symporter activity
G4H71_RS03240	COG1609	Transcriptional regulator
G4H71_RS03250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS03285	COG0431	NADPH-dependent FMN reductase
G4H71_RS03300	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4H71_RS03330	COG0183	Belongs to the thiolase family
G4H71_RS03335	COG0667	Aldo Keto reductase
G4H71_RS03345	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G4H71_RS03365	COG1022	Amp-dependent synthetase and ligase
G4H71_RS03385	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS03390	COG1136	(ABC) transporter
G4H71_RS03390	COG0577	efflux transmembrane transporter activity
G4H71_RS03395	COG0577	efflux transmembrane transporter activity
G4H71_RS03395	COG1136	(ABC) transporter
G4H71_RS03400	COG3012	SEC-C Motif Domain Protein
G4H71_RS03410	COG1132	(ABC) transporter
G4H71_RS03430	COG0628	permease
G4H71_RS03470	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
G4H71_RS03475	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS03480	COG1024	Enoyl-CoA hydratase
G4H71_RS03500	COG0435	Glutathione S-transferase
G4H71_RS03530	COG1132	(ABC) transporter
G4H71_RS03535	COG0508	dehydrogenase complex catalyzes the overall conversion of
G4H71_RS03535	COG0567	Dehydrogenase, E1 component
G4H71_RS03575	COG1125	glycine betaine transport
G4H71_RS03575	COG0517	IMP dehydrogenase activity
G4H71_RS03580	COG1174	glycine betaine transport
G4H71_RS03600	COG2095	MarC family integral membrane protein
G4H71_RS03605	COG0613	PHP domain protein
G4H71_RS03620	COG0477	Major facilitator Superfamily
G4H71_RS03630	COG2301	Belongs to the HpcH HpaI aldolase family
G4H71_RS03635	COG2239	Acts as a magnesium transporter
G4H71_RS03665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4H71_RS03670	COG5662	AntiSigma factor
G4H71_RS03690	COG0297	glycogen (starch) synthase activity
G4H71_RS03705	COG2226	methyltransferase
G4H71_RS03715	COG0519	Catalyzes the synthesis of GMP from XMP
G4H71_RS03725	COG0463	Glycosyl transferase, family 2
G4H71_RS03730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4H71_RS03735	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS03740	COG1611	Belongs to the LOG family
G4H71_RS03745	COG1611	Belongs to the LOG family
G4H71_RS03750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4H71_RS03755	COG2171	N-acyltransferase activity
G4H71_RS03760	COG1113	amino acid transport
G4H71_RS03770	COG2130	NADP-dependent
G4H71_RS03775	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS03790	COG0506	proline dehydrogenase activity
G4H71_RS03795	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS03820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4H71_RS03870	COG0747	negative chemotaxis
G4H71_RS03875	COG1217	gtp-binding protein TYPA
G4H71_RS03885	COG2154	pterin-4-alpha-carbinolamine dehydratase
G4H71_RS03890	COG1051	belongs to the nudix hydrolase family
G4H71_RS03910	COG3757	hydrolase, family 25
G4H71_RS03930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4H71_RS03930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4H71_RS03940	COG3663	DNA glycosylase
G4H71_RS03970	COG2814	Major facilitator Superfamily
G4H71_RS03990	COG4115	mRNA cleavage
G4H71_RS03995	COG2161	toxin-antitoxin pair type II binding
G4H71_RS04005	COG0012	GTP binding
G4H71_RS04020	COG0419	ATPase involved in DNA repair
G4H71_RS04025	COG0420	3'-5' exonuclease activity
G4H71_RS04045	COG1570	exodeoxyribonuclease VII activity
G4H71_RS04065	COG2197	response regulator
G4H71_RS04115	COG1216	Glycosyl transferase, family 2
G4H71_RS04145	COG1216	Glycosyl transferase, family 2
G4H71_RS04155	COG1215	transferase activity, transferring glycosyl groups
G4H71_RS04165	COG0477	Major facilitator Superfamily
G4H71_RS04180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4H71_RS04190	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G4H71_RS04195	COG1535	isochorismatase
G4H71_RS04195	COG3433	isochorismatase activity
G4H71_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS04205	COG1021	2,3-dihydroxybenzoate-AMP ligase
G4H71_RS04215	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
G4H71_RS04220	COG2226	methyltransferase
G4H71_RS04230	COG1309	transcriptional regulator
G4H71_RS04235	COG2072	flavoprotein involved in K transport
G4H71_RS04240	COG4221	oxidoreductase activity
G4H71_RS04245	COG4689	acetoacetate decarboxylase
G4H71_RS04250	COG1902	pentaerythritol trinitrate reductase activity
G4H71_RS04250	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS04255	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4H71_RS04265	COG1072	(Pantothenic acid kinase))
G4H71_RS04270	COG2391	methyltransferase activity
G4H71_RS04275	COG2897	thiosulfate sulfurtransferase activity
G4H71_RS04280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G4H71_RS04295	COG1131	(ABC) transporter
G4H71_RS04300	COG3559	Exporter of polyketide antibiotics
G4H71_RS04305	COG1331	Highly conserved protein containing a thioredoxin domain
G4H71_RS04315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4H71_RS04325	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4H71_RS04330	COG3883	PFAM NLP P60 protein
G4H71_RS04330	COG0791	NLP P60 protein
G4H71_RS04345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G4H71_RS04365	COG2755	lipolytic protein G-D-S-L family
G4H71_RS04370	COG0183	Belongs to the thiolase family
G4H71_RS04395	COG0753	catalase activity
G4H71_RS04440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS04470	COG0300	oxidoreductase activity
G4H71_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS04485	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS04490	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS04515	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS04535	COG2030	dehydratase
G4H71_RS04540	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS04545	COG0183	Belongs to the thiolase family
G4H71_RS04550	COG1309	transcriptional regulator
G4H71_RS04555	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS04575	COG0346	lactoylglutathione lyase activity
G4H71_RS04585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4H71_RS04590	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G4H71_RS04595	COG3971	2-oxopent-4-enoate hydratase activity
G4H71_RS04605	COG1414	Transcriptional regulator
G4H71_RS04610	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS04620	COG0477	Major facilitator Superfamily
G4H71_RS04630	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS04635	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS04635	COG1902	pentaerythritol trinitrate reductase activity
G4H71_RS04640	COG0604	alcohol dehydrogenase
G4H71_RS04650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS04690	COG0148	phosphopyruvate hydratase activity
G4H71_RS04705	COG3956	TIGRFAM MazG family protein
G4H71_RS04715	COG1309	transcriptional regulator
G4H71_RS04745	COG1115	amino acid carrier protein
G4H71_RS04770	COG2133	pyrroloquinoline quinone binding
G4H71_RS04775	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
G4H71_RS04780	COG0121	glutamine amidotransferase
G4H71_RS04785	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4H71_RS04795	COG0438	transferase activity, transferring glycosyl groups
G4H71_RS04800	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4H71_RS04815	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4H71_RS04820	COG0644	oxidoreductase
G4H71_RS04835	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS04840	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
G4H71_RS04860	COG3550	peptidyl-serine autophosphorylation
G4H71_RS04870	COG0488	(ABC) transporter
G4H71_RS04875	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4H71_RS04900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4H71_RS04905	COG3583	domain protein
G4H71_RS04910	COG3583	domain protein
G4H71_RS04915	COG0765	amino acid transport
G4H71_RS04920	COG1126	abc transporter atp-binding protein
G4H71_RS04930	COG0084	hydrolase, TatD family'
G4H71_RS04975	COG1725	Transcriptional regulator
G4H71_RS04990	COG2235	arginine
G4H71_RS04995	COG0789	Transcriptional regulator
G4H71_RS05010	COG2365	Tyrosine phosphatase family
G4H71_RS05030	COG2132	Multicopper oxidase
G4H71_RS05045	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4H71_RS05065	COG1132	(ABC) transporter
G4H71_RS05100	COG0477	Major facilitator Superfamily
G4H71_RS05160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4H71_RS05170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4H71_RS05175	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4H71_RS05190	COG1970	mechanosensitive ion channel activity
G4H71_RS05230	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4H71_RS05235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4H71_RS05240	COG2205	protein histidine kinase activity
G4H71_RS05250	COG2860	membrane
G4H71_RS05260	COG0254	rRNA binding
G4H71_RS05270	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4H71_RS05280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G4H71_RS05285	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4H71_RS05295	COG1320	monovalent cation:proton antiporter activity
G4H71_RS05310	COG0651	ATP synthesis coupled electron transport
G4H71_RS05320	COG0651	ATP synthesis coupled electron transport
G4H71_RS05350	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4H71_RS05360	COG3409	Peptidoglycan-binding domain 1 protein
G4H71_RS05360	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4H71_RS05395	COG1739	Uncharacterized protein family UPF0029
G4H71_RS05415	COG0739	heme binding
G4H71_RS05435	COG0166	Belongs to the GPI family
G4H71_RS05445	COG1252	NADH dehydrogenase
G4H71_RS05455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4H71_RS05460	COG2272	Belongs to the type-B carboxylesterase lipase family
G4H71_RS05470	COG1024	Enoyl-CoA hydratase
G4H71_RS05475	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4H71_RS05480	COG0154	amidase activity
G4H71_RS05535	COG2267	carboxylic ester hydrolase activity
G4H71_RS05540	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
G4H71_RS05595	COG2066	Belongs to the glutaminase family
G4H71_RS05605	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS05630	COG1113	amino acid transport
G4H71_RS05635	COG2030	dehydratase
G4H71_RS05645	COG1131	(ABC) transporter
G4H71_RS05720	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4H71_RS05730	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G4H71_RS05740	COG3279	Response regulator of the LytR AlgR family
G4H71_RS05745	COG3275	phosphorelay sensor kinase activity
G4H71_RS05770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4H71_RS05795	COG2409	Drug exporters of the RND superfamily
G4H71_RS05800	COG0656	L-ascorbic acid biosynthetic process
G4H71_RS05805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4H71_RS05810	COG0488	(ABC) transporter
G4H71_RS05830	COG4152	abc transporter atp-binding protein
G4H71_RS05835	COG1668	transmembrane transport
G4H71_RS05845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4H71_RS05850	COG0640	Transcriptional regulator
G4H71_RS05855	COG0798	PFAM Bile acid sodium symporter
G4H71_RS05860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4H71_RS05870	COG0640	Transcriptional regulator
G4H71_RS05905	COG0415	Belongs to the DNA photolyase family
G4H71_RS05910	COG0668	transmembrane transport
G4H71_RS05925	COG0545	Peptidyl-prolyl cis-trans isomerase
G4H71_RS05935	COG2017	converts alpha-aldose to the beta-anomer
G4H71_RS05940	COG0477	Major facilitator Superfamily
G4H71_RS05945	COG0259	pyridoxamine-phosphate oxidase activity
G4H71_RS05955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G4H71_RS05990	COG2814	Major facilitator Superfamily
G4H71_RS06000	COG2252	PERMEase
G4H71_RS06030	COG2814	Major facilitator Superfamily
G4H71_RS06040	COG1278	Cold shock
G4H71_RS06055	COG1652	LysM domain
G4H71_RS06075	COG1132	(ABC) transporter
G4H71_RS06080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS06085	COG1116	anion transmembrane transporter activity
G4H71_RS06105	COG1061	Type III restriction enzyme res subunit
G4H71_RS06110	COG4565	transcriptional regulatory protein
G4H71_RS06115	COG3290	protein histidine kinase activity
G4H71_RS06120	COG2851	Citrate transporter
G4H71_RS06130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS06135	COG2814	Major facilitator Superfamily
G4H71_RS06140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS06145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS06160	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4H71_RS06165	COG1595	DNA-templated transcription, initiation
G4H71_RS06205	COG5285	phytanoyl-CoA dioxygenase
G4H71_RS06235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
G4H71_RS06240	COG2764	glyoxalase bleomycin resistance protein dioxygenase
G4H71_RS06250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4H71_RS06255	COG1120	ATPase activity
G4H71_RS06260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4H71_RS06265	COG0542	response to heat
G4H71_RS06275	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4H71_RS06285	COG1595	DNA-templated transcription, initiation
G4H71_RS06295	COG1846	Transcriptional regulator
G4H71_RS06300	COG1764	response to oxidative stress
G4H71_RS06305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS06320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS06325	COG0564	pseudouridine synthase activity
G4H71_RS06345	COG1309	transcriptional regulator
G4H71_RS06350	COG2409	Drug exporters of the RND superfamily
G4H71_RS06355	COG1309	transcriptional regulator
G4H71_RS06420	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4H71_RS06425	COG0581	inorganic phosphate transmembrane transporter activity
G4H71_RS06445	COG0745	RESPONSE REGULATOR receiver
G4H71_RS06465	COG2897	thiosulfate sulfurtransferase activity
G4H71_RS06480	COG4044	May play a role in the intracellular transport of hydrophobic ligands
G4H71_RS06485	COG1660	Displays ATPase and GTPase activities
G4H71_RS06490	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
G4H71_RS06495	COG4988	ABC transporter
G4H71_RS06500	COG1294	oxidase, subunit
G4H71_RS06505	COG1271	oxidase subunit
G4H71_RS06535	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G4H71_RS06575	COG2249	NAD(P)H dehydrogenase (quinone) activity
G4H71_RS06580	COG1464	Belongs to the NlpA lipoprotein family
G4H71_RS06590	COG2011	ABC-type metal ion transport system permease component
G4H71_RS06595	COG0477	Major facilitator Superfamily
G4H71_RS06600	COG1362	aminopeptidase activity
G4H71_RS06615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4H71_RS06640	COG0047	phosphoribosylformylglycinamidine synthase activity
G4H71_RS06645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4H71_RS06655	COG0500	methyltransferase
G4H71_RS06680	COG0789	Transcriptional regulator
G4H71_RS06705	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS06730	COG3226	Transcriptional regulator
G4H71_RS06740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4H71_RS06745	COG0386	Belongs to the glutathione peroxidase family
G4H71_RS06770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G4H71_RS06775	COG0477	Major facilitator Superfamily
G4H71_RS06790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4H71_RS06800	COG0436	Aminotransferase
G4H71_RS06825	COG5000	phosphorelay sensor kinase activity
G4H71_RS06825	COG5002	protein histidine kinase activity
G4H71_RS06830	COG0745	RESPONSE REGULATOR receiver
G4H71_RS06875	COG3486	L-lysine 6-monooxygenase (NADPH) activity
G4H71_RS06895	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
G4H71_RS06925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4H71_RS06950	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS06955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS06960	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS06970	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS06975	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS06980	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS06985	COG2070	2-Nitropropane dioxygenase
G4H71_RS06995	COG1024	Enoyl-CoA hydratase
G4H71_RS07010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS07045	COG2124	cytochrome p450
G4H71_RS07050	COG0183	Belongs to the thiolase family
G4H71_RS07100	COG0028	Belongs to the TPP enzyme family
G4H71_RS07110	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS07140	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS07145	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
G4H71_RS07150	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4H71_RS07165	COG1116	anion transmembrane transporter activity
G4H71_RS07165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4H71_RS07170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS07185	COG1846	Transcriptional regulator
G4H71_RS07200	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS07205	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS07210	COG1024	Enoyl-CoA hydratase
G4H71_RS07230	COG1309	transcriptional regulator
G4H71_RS07275	COG0183	Belongs to the thiolase family
G4H71_RS07280	COG1309	transcriptional regulator
G4H71_RS07285	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS07290	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07295	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS07300	COG1024	Enoyl-CoA hydratase
G4H71_RS07305	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07315	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07320	COG4941	Belongs to the sigma-70 factor family
G4H71_RS07325	COG3795	YCII-related domain
G4H71_RS07345	COG0561	phosphatase activity
G4H71_RS07350	COG0656	L-ascorbic acid biosynthetic process
G4H71_RS07355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G4H71_RS07360	COG1074	ATP-dependent DNA helicase activity
G4H71_RS07380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4H71_RS07385	COG0346	lactoylglutathione lyase activity
G4H71_RS07390	COG2267	carboxylic ester hydrolase activity
G4H71_RS07395	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4H71_RS07420	COG4569	acetaldehyde dehydrogenase (acetylating) activity
G4H71_RS07425	COG3971	2-oxopent-4-enoate hydratase activity
G4H71_RS07435	COG1053	succinate dehydrogenase
G4H71_RS07440	COG2030	dehydratase
G4H71_RS07475	COG4266	Belongs to the allantoicase family
G4H71_RS07485	COG1802	Transcriptional regulator
G4H71_RS07510	COG1953	Uracil, thiamine, allantoin
G4H71_RS07520	COG0402	S-adenosylhomocysteine deaminase activity
G4H71_RS07530	COG2351	hydroxyisourate hydrolase activity
G4H71_RS07550	COG2080	2 iron, 2 sulfur cluster binding
G4H71_RS07550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
G4H71_RS07585	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07590	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07595	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS07600	COG1309	transcriptional regulator
G4H71_RS07605	COG0561	phosphatase activity
G4H71_RS07605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4H71_RS07615	COG1609	Transcriptional regulator
G4H71_RS07625	COG1121	(ABC) transporter
G4H71_RS07630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4H71_RS07640	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
G4H71_RS07645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
G4H71_RS07650	COG1984	allophanate hydrolase subunit 2
G4H71_RS07665	COG3328	transposase activity
G4H71_RS07705	COG0215	cysteine-tRNA ligase activity
G4H71_RS07715	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4H71_RS07720	COG1329	Transcriptional regulator
G4H71_RS07730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4H71_RS07740	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
G4H71_RS07750	COG0288	reversible hydration of carbon dioxide
G4H71_RS07755	COG1194	a g-specific adenine glycosylase
G4H71_RS07830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4H71_RS07845	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4H71_RS07850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G4H71_RS07855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4H71_RS07890	COG0302	gtp cyclohydrolase
G4H71_RS07905	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
G4H71_RS07920	COG2027	D-alanyl-D-alanine carboxypeptidase
G4H71_RS07940	COG1024	Enoyl-CoA hydratase
G4H71_RS07950	COG1309	transcriptional regulator
G4H71_RS07960	COG0442	prolyl-tRNA aminoacylation
G4H71_RS07965	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4H71_RS07980	COG4941	Belongs to the sigma-70 factor family
G4H71_RS07995	COG0308	aminopeptidase N
G4H71_RS08010	COG1126	abc transporter atp-binding protein
G4H71_RS08015	COG0765	amino acid transport
G4H71_RS08020	COG0765	amino acid transport
G4H71_RS08065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4H71_RS08065	COG1754	DNA topoisomerase type I activity
G4H71_RS08075	COG1278	Cold shock
G4H71_RS08080	COG1111	helicase
G4H71_RS08080	COG1205	dead DEAH box helicase
G4H71_RS08085	COG2239	Acts as a magnesium transporter
G4H71_RS08145	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4H71_RS08155	COG0477	Major facilitator Superfamily
G4H71_RS08170	COG1863	multisubunit Na H antiporter MnhE subunit
G4H71_RS08175	COG0651	ATP synthesis coupled electron transport
G4H71_RS08185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4H71_RS08185	COG2111	Na H antiporter
G4H71_RS08195	COG0596	Alpha beta hydrolase
G4H71_RS08230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4H71_RS08270	COG1408	metallophosphoesterase
G4H71_RS08305	COG0546	phosphoglycolate phosphatase activity
G4H71_RS08395	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS08415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G4H71_RS08440	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4H71_RS08450	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4H71_RS08505	COG0640	Transcriptional regulator
G4H71_RS08515	COG2814	Major facilitator Superfamily
G4H71_RS08520	COG1309	transcriptional regulator
G4H71_RS08525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4H71_RS08530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4H71_RS08545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4H71_RS08560	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4H71_RS08560	COG1024	Enoyl-CoA hydratase
G4H71_RS08565	COG0183	Belongs to the thiolase family
G4H71_RS08585	COG4592	Periplasmic binding protein
G4H71_RS08590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS08635	COG3226	Transcriptional regulator
G4H71_RS08640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4H71_RS08665	COG0343	queuine tRNA-ribosyltransferase activity
G4H71_RS08675	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
G4H71_RS08680	COG1253	flavin adenine dinucleotide binding
G4H71_RS08685	COG3119	arylsulfatase activity
G4H71_RS08690	COG1262	PFAM Formylglycine-generating sulfatase enzyme
G4H71_RS08705	COG4424	Sulfotransferase
G4H71_RS08720	COG2409	Drug exporters of the RND superfamily
G4H71_RS08760	COG0251	oxidation-reduction process
G4H71_RS08790	COG3237	CsbD-like
G4H71_RS08795	COG0590	tRNA wobble adenosine to inosine editing
G4H71_RS08805	COG0287	Prephenate dehydrogenase
G4H71_RS08810	COG2326	polyphosphate kinase activity
G4H71_RS08825	COG0270	DNA (cytosine-5-)-methyltransferase activity
G4H71_RS08870	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4H71_RS08875	COG5479	isomerase activity
G4H71_RS08875	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS08890	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS08890	COG3321	synthase
G4H71_RS08890	COG0604	alcohol dehydrogenase
G4H71_RS08915	COG1216	Glycosyl transferase, family 2
G4H71_RS08920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS08925	COG0697	spore germination
G4H71_RS08980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
G4H71_RS08985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
G4H71_RS08995	COG1215	transferase activity, transferring glycosyl groups
G4H71_RS09000	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS09025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4H71_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS09100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4H71_RS09105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4H71_RS09105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G4H71_RS09105	COG3321	synthase
G4H71_RS09110	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS09120	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G4H71_RS09130	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS09130	COG5479	isomerase activity
G4H71_RS09135	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS09145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4H71_RS09150	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4H71_RS09155	COG0671	phosphoesterase, PA-phosphatase related
G4H71_RS09160	COG1216	Glycosyl transferase, family 2
G4H71_RS09175	COG0438	transferase activity, transferring glycosyl groups
G4H71_RS09180	COG2385	sporulation resulting in formation of a cellular spore
G4H71_RS09190	COG0561	phosphatase activity
G4H71_RS09200	COG0204	Acyl-transferase
G4H71_RS09210	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4H71_RS09210	COG2146	nitrite reductase [NAD(P)H] activity
G4H71_RS09220	COG2193	ferroxidase activity
G4H71_RS09230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4H71_RS09300	COG1316	TRANSCRIPTIONal
G4H71_RS09305	COG1528	Iron-storage protein
G4H71_RS09345	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4H71_RS09370	COG2119	membrane
G4H71_RS09460	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4H71_RS09475	COG2197	response regulator
G4H71_RS09480	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS09485	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4H71_RS09500	COG1024	Enoyl-CoA hydratase
G4H71_RS09510	COG0702	epimerase
G4H71_RS09515	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
G4H71_RS09520	COG0596	Alpha beta hydrolase
G4H71_RS09525	COG1733	regulation of RNA biosynthetic process
G4H71_RS09535	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4H71_RS09540	COG2501	S4 domain
G4H71_RS09565	COG0154	amidase activity
G4H71_RS09595	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
G4H71_RS09625	COG0067	glutamate synthase
G4H71_RS09625	COG0069	glutamate synthase activity
G4H71_RS09625	COG0070	glutamate synthase
G4H71_RS09700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS09705	COG2217	Heavy metal translocating P-type atpase
G4H71_RS09710	COG4308	Limonene-1,2-epoxide hydrolase catalytic domain
G4H71_RS09730	COG2066	Belongs to the glutaminase family
G4H71_RS09765	COG2375	cellular response to nickel ion
G4H71_RS09765	COG1132	(ABC) transporter
G4H71_RS09770	COG1132	(ABC) transporter
G4H71_RS09805	COG3328	transposase activity
G4H71_RS09815	COG1716	ATPase activity
G4H71_RS09820	COG1716	ATPase activity
G4H71_RS09835	COG0768	penicillin binding
G4H71_RS09845	COG2815	serine threonine protein kinase
G4H71_RS09845	COG0515	serine threonine protein kinase
G4H71_RS09870	COG0705	Rhomboid family
G4H71_RS09870	COG0457	Tetratricopeptide repeat
G4H71_RS09910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4H71_RS09915	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4H71_RS09920	COG0649	NAD binding
G4H71_RS09930	COG1034	ATP synthesis coupled electron transport
G4H71_RS09935	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4H71_RS09940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4H71_RS09950	COG0713	ATP synthesis coupled electron transport
G4H71_RS10015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
G4H71_RS10035	COG2018	Roadblock/LC7 domain
G4H71_RS10040	COG2205	protein histidine kinase activity
G4H71_RS10065	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
G4H71_RS10070	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
G4H71_RS10075	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
G4H71_RS10080	COG0592	DNA-directed DNA polymerase activity
G4H71_RS10090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4H71_RS10100	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4H71_RS10105	COG0706	membrane insertase activity
G4H71_RS10125	COG0357	Ribosomal RNA small subunit methyltransferase G
G4H71_RS10130	COG1192	Involved in chromosome partitioning
G4H71_RS10145	COG0860	N-Acetylmuramoyl-L-alanine amidase
G4H71_RS10145	COG3409	Peptidoglycan-binding domain 1 protein
G4H71_RS10170	COG1595	DNA-templated transcription, initiation
G4H71_RS10190	COG0617	tRNA 3'-terminal CCA addition
G4H71_RS10200	COG0243	molybdopterin cofactor binding
G4H71_RS10210	COG3585	molybdate ion transport
G4H71_RS10260	COG1678	Uncharacterized ACR, COG1678
G4H71_RS10295	COG0495	leucyl-tRNA aminoacylation
G4H71_RS10315	COG3631	Ketosteroid isomerase-related protein
G4H71_RS10325	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS10335	COG1247	-acetyltransferase
G4H71_RS10375	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10380	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10400	COG0702	epimerase
G4H71_RS10430	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4H71_RS10435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4H71_RS10445	COG1595	DNA-templated transcription, initiation
G4H71_RS10450	COG5343	regulation of RNA biosynthetic process
G4H71_RS10485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4H71_RS10485	COG1796	DNA polymerase
G4H71_RS10510	COG0183	Belongs to the thiolase family
G4H71_RS10520	COG0183	Belongs to the thiolase family
G4H71_RS10525	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10530	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10535	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10545	COG2186	Transcriptional regulator
G4H71_RS10555	COG0477	Major facilitator Superfamily
G4H71_RS10585	COG2271	Major facilitator Superfamily
G4H71_RS10590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4H71_RS10595	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10630	COG1253	flavin adenine dinucleotide binding
G4H71_RS10645	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS10645	COG0604	alcohol dehydrogenase
G4H71_RS10645	COG3321	synthase
G4H71_RS10665	COG1309	transcriptional regulator
G4H71_RS10670	COG1902	pentaerythritol trinitrate reductase activity
G4H71_RS10670	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS10690	COG1937	Protein conserved in bacteria
G4H71_RS10710	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
G4H71_RS10725	COG1053	succinate dehydrogenase
G4H71_RS10750	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10765	COG1024	Enoyl-CoA hydratase
G4H71_RS10770	COG1126	abc transporter atp-binding protein
G4H71_RS10775	COG0765	amino acid transport
G4H71_RS10780	COG1309	transcriptional regulator
G4H71_RS10790	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS10800	COG0778	Nitroreductase
G4H71_RS10815	COG1131	(ABC) transporter
G4H71_RS10830	COG2197	response regulator
G4H71_RS10835	COG1309	transcriptional regulator
G4H71_RS10870	COG3627	carbon phosphorus lyase activity
G4H71_RS10875	COG1126	abc transporter atp-binding protein
G4H71_RS10880	COG3454	Phosphonate metabolism
G4H71_RS10895	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G4H71_RS10900	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
G4H71_RS10905	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
G4H71_RS10910	COG3639	organic phosphonate transmembrane transporter activity
G4H71_RS10920	COG3842	ATPase activity
G4H71_RS10955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4H71_RS10960	COG1260	myo-inositol-1-phosphate synthase
G4H71_RS10965	COG1695	Transcriptional regulator
G4H71_RS10980	COG0477	Major facilitator Superfamily
G4H71_RS11005	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
G4H71_RS11025	COG0629	single-stranded DNA binding
G4H71_RS11030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4H71_RS11035	COG0359	binds to the 23S rRNA
G4H71_RS11040	COG0305	Participates in initiation and elongation during chromosome replication
G4H71_RS11065	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
G4H71_RS11065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4H71_RS11090	COG3973	AAA domain
G4H71_RS11115	COG2837	iron assimilation
G4H71_RS11160	COG2814	Major facilitator Superfamily
G4H71_RS11180	COG0693	protein deglycase activity
G4H71_RS11185	COG0477	Major facilitator Superfamily
G4H71_RS11210	COG0384	phenazine biosynthesis protein PhzF
G4H71_RS11220	COG1522	sequence-specific DNA binding
G4H71_RS11225	COG2409	Drug exporters of the RND superfamily
G4H71_RS11260	COG2813	Specifically methylates the guanine in position
G4H71_RS11265	COG1609	Transcriptional regulator
G4H71_RS11270	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS11290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4H71_RS11295	COG1126	abc transporter atp-binding protein
G4H71_RS11325	COG0559	Belongs to the binding-protein-dependent transport system permease family
G4H71_RS11365	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4H71_RS11370	COG1414	Transcriptional regulator
G4H71_RS11375	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4H71_RS11380	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
G4H71_RS11390	COG3226	Transcriptional regulator
G4H71_RS11395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4H71_RS11400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4H71_RS11405	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS11415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4H71_RS11420	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4H71_RS11455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS11465	COG2186	Transcriptional regulator
G4H71_RS11500	COG1937	Protein conserved in bacteria
G4H71_RS11510	COG1132	(ABC) transporter
G4H71_RS11515	COG1132	(ABC) transporter
G4H71_RS11540	COG1335	isochorismatase
G4H71_RS11575	COG0583	DNA-binding transcription factor activity
G4H71_RS11585	COG0402	S-adenosylhomocysteine deaminase activity
G4H71_RS11590	COG1741	Belongs to the pirin family
G4H71_RS11605	COG3835	regulator
G4H71_RS11615	COG0542	response to heat
G4H71_RS11650	COG0402	S-adenosylhomocysteine deaminase activity
G4H71_RS11655	COG1058	Belongs to the CinA family
G4H71_RS11655	COG1546	Belongs to the CinA family
G4H71_RS11670	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS11675	COG1053	succinate dehydrogenase
G4H71_RS11680	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
G4H71_RS11705	COG1309	transcriptional regulator
G4H71_RS11720	COG1309	transcriptional regulator
G4H71_RS11775	COG1309	transcriptional regulator
G4H71_RS11790	COG0346	lactoylglutathione lyase activity
G4H71_RS11820	COG3328	transposase activity
G4H71_RS11840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4H71_RS11855	COG0657	acetylesterase activity
G4H71_RS11870	COG2267	carboxylic ester hydrolase activity
G4H71_RS11875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4H71_RS11895	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4H71_RS11900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4H71_RS11905	COG2814	Major facilitator Superfamily
G4H71_RS11940	COG1940	carbohydrate kinase activity
G4H71_RS11945	COG1063	alcohol dehydrogenase
G4H71_RS11955	COG0596	Alpha beta hydrolase
G4H71_RS11985	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS11990	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS12010	COG3226	Transcriptional regulator
G4H71_RS12015	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12035	COG2409	Drug exporters of the RND superfamily
G4H71_RS12055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4H71_RS12070	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS12085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4H71_RS12090	COG0477	Major facilitator Superfamily
G4H71_RS12105	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS12110	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12115	COG2271	Major facilitator Superfamily
G4H71_RS12120	COG0183	Belongs to the thiolase family
G4H71_RS12130	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS12135	COG0583	DNA-binding transcription factor activity
G4H71_RS12145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4H71_RS12150	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS12160	COG1024	Enoyl-CoA hydratase
G4H71_RS12165	COG0183	Belongs to the thiolase family
G4H71_RS12170	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12180	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12200	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4H71_RS12220	COG2188	Transcriptional regulator
G4H71_RS12230	COG0183	Belongs to the thiolase family
G4H71_RS12235	COG1024	Enoyl-CoA hydratase
G4H71_RS12270	COG1024	Enoyl-CoA hydratase
G4H71_RS12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4H71_RS12280	COG0702	epimerase
G4H71_RS12290	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12295	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS12300	COG2030	dehydratase
G4H71_RS12310	COG0183	Belongs to the thiolase family
G4H71_RS12325	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS12330	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
G4H71_RS12335	COG0659	secondary active sulfate transmembrane transporter activity
G4H71_RS12345	COG0477	Major facilitator Superfamily
G4H71_RS12360	COG1309	transcriptional regulator
G4H71_RS12365	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
G4H71_RS12385	COG0129	dihydroxy-acid dehydratase activity
G4H71_RS12405	COG3655	Transcriptional regulator
G4H71_RS12410	COG0667	Aldo Keto reductase
G4H71_RS12460	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4H71_RS12485	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS12500	COG0598	Magnesium transport protein CorA
G4H71_RS12505	COG1793	dna ligase
G4H71_RS12525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
G4H71_RS12535	COG1376	ErfK ybiS ycfS ynhG family protein
G4H71_RS12555	COG3842	ATPase activity
G4H71_RS12560	COG3590	peptidase
G4H71_RS12590	COG0135	phosphoribosylanthranilate isomerase activity
G4H71_RS12595	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS12600	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12610	COG0488	(ABC) transporter
G4H71_RS12645	COG1309	transcriptional regulator
G4H71_RS12675	COG4585	Histidine kinase
G4H71_RS12680	COG2197	response regulator
G4H71_RS12720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G4H71_RS12740	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
G4H71_RS12750	COG1045	serine acetyltransferase
G4H71_RS12755	COG0406	alpha-ribazole phosphatase activity
G4H71_RS12760	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
G4H71_RS12765	COG1178	ABC-type Fe3 transport system permease component
G4H71_RS12780	COG1737	Transcriptional regulator
G4H71_RS12805	COG0500	methyltransferase
G4H71_RS12835	COG4981	capsule polysaccharide biosynthetic process
G4H71_RS12845	COG0589	response to stress
G4H71_RS12850	COG1472	Belongs to the glycosyl hydrolase 3 family
G4H71_RS12860	COG1309	transcriptional regulator
G4H71_RS12865	COG2030	dehydratase
G4H71_RS12870	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS12875	COG0183	Belongs to the thiolase family
G4H71_RS12880	COG2720	vancomycin resistance protein
G4H71_RS12885	COG0277	FAD linked oxidase domain protein
G4H71_RS12895	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS12960	COG1793	dna ligase
G4H71_RS12965	COG2197	response regulator
G4H71_RS12970	COG4585	Histidine kinase
G4H71_RS12990	COG3285	dna ligase
G4H71_RS12990	COG1793	dna ligase
G4H71_RS12995	COG2233	PERMEase
G4H71_RS13005	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS13005	COG5479	isomerase activity
G4H71_RS13010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
G4H71_RS13025	COG4585	Histidine kinase
G4H71_RS13115	COG0492	ferredoxin-NADP+ reductase activity
G4H71_RS13150	COG3795	YCII-related domain
G4H71_RS13155	COG4941	Belongs to the sigma-70 factor family
G4H71_RS13195	COG0583	DNA-binding transcription factor activity
G4H71_RS13200	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS13220	COG0628	permease
G4H71_RS13230	COG0659	secondary active sulfate transmembrane transporter activity
G4H71_RS13240	COG1115	amino acid carrier protein
G4H71_RS13245	COG1366	Belongs to the anti-sigma-factor antagonist family
G4H71_RS13335	COG3467	pyridoxamine 5'-phosphate
G4H71_RS13395	COG0439	Biotin carboxylase
G4H71_RS13400	COG0477	Major facilitator Superfamily
G4H71_RS13410	COG1554	hydrolase, family 65, central catalytic
G4H71_RS13505	COG5433	transposase activity
G4H71_RS13530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4H71_RS13535	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4H71_RS13540	COG0443	Heat shock 70 kDa protein
G4H71_RS13580	COG1506	peptidase
G4H71_RS13580	COG0823	Involved in the tonB-independent uptake of proteins
G4H71_RS13580	COG4946	Tricorn protease homolog
G4H71_RS13590	COG0247	lactate metabolic process
G4H71_RS13590	COG2181	nitrate reductase activity
G4H71_RS13630	COG2132	Multicopper oxidase
G4H71_RS13635	COG2318	DinB family
G4H71_RS13650	COG0443	Heat shock 70 kDa protein
G4H71_RS13655	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4H71_RS13660	COG0484	heat shock protein binding
G4H71_RS13665	COG0789	Transcriptional regulator
G4H71_RS13670	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4H71_RS13675	COG1121	(ABC) transporter
G4H71_RS13680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4H71_RS13685	COG2072	flavoprotein involved in K transport
G4H71_RS13700	COG0411	ABC transporter
G4H71_RS13740	COG3631	Ketosteroid isomerase-related protein
G4H71_RS13750	COG0657	acetylesterase activity
G4H71_RS13760	COG0346	lactoylglutathione lyase activity
G4H71_RS13775	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4H71_RS13780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4H71_RS13785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4H71_RS13790	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS13795	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4H71_RS13795	COG1017	nitric oxide dioxygenase activity
G4H71_RS13815	COG2871	sodium ion transport
G4H71_RS13850	COG0542	response to heat
G4H71_RS13870	COG3842	ATPase activity
G4H71_RS13885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS13895	COG2814	Major facilitator Superfamily
G4H71_RS13900	COG0076	glutamate decarboxylase activity
G4H71_RS13945	COG0586	Pfam SNARE associated Golgi protein
G4H71_RS13970	COG4129	membrane
G4H71_RS13980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4H71_RS13995	COG0183	Belongs to the thiolase family
G4H71_RS14005	COG1994	Peptidase M50
G4H71_RS14015	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4H71_RS14030	COG0702	epimerase
G4H71_RS14040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4H71_RS14065	COG2197	response regulator
G4H71_RS14070	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4H71_RS14085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS14090	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4H71_RS14105	COG5433	transposase activity
G4H71_RS14130	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
G4H71_RS14150	COG2175	clavaminate synthase activity
G4H71_RS14160	COG1595	DNA-templated transcription, initiation
G4H71_RS14165	COG1302	Protein conserved in bacteria
G4H71_RS14200	COG0640	Transcriptional regulator
G4H71_RS14225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4H71_RS14230	COG0640	Transcriptional regulator
G4H71_RS14235	COG0798	PFAM Bile acid sodium symporter
G4H71_RS14240	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4H71_RS14245	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
G4H71_RS14250	COG2205	protein histidine kinase activity
G4H71_RS14255	COG0745	RESPONSE REGULATOR receiver
G4H71_RS14265	COG2132	Multicopper oxidase
G4H71_RS14275	COG2217	Heavy metal translocating P-type atpase
G4H71_RS14300	COG1937	Protein conserved in bacteria
G4H71_RS14305	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
G4H71_RS14310	COG1396	sequence-specific DNA binding
G4H71_RS14340	COG0492	ferredoxin-NADP+ reductase activity
G4H71_RS14350	COG2072	flavoprotein involved in K transport
G4H71_RS14395	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4H71_RS14400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4H71_RS14405	COG1120	ATPase activity
G4H71_RS14425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
G4H71_RS14495	COG0747	negative chemotaxis
G4H71_RS14505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4H71_RS14510	COG4172	Belongs to the ABC transporter superfamily
G4H71_RS14515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS14530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS14540	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS14545	COG0640	Transcriptional regulator
G4H71_RS14550	COG0346	lactoylglutathione lyase activity
G4H71_RS14565	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G4H71_RS14580	COG1309	transcriptional regulator
G4H71_RS14605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4H71_RS14610	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS14625	COG2409	Drug exporters of the RND superfamily
G4H71_RS14645	COG0515	serine threonine protein kinase
G4H71_RS14650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4H71_RS14665	COG0352	thiamine-phosphate diphosphorylase activity
G4H71_RS14670	COG2022	thiamine diphosphate biosynthetic process
G4H71_RS14670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G4H71_RS14680	COG2022	thiamine diphosphate biosynthetic process
G4H71_RS14685	COG1131	(ABC) transporter
G4H71_RS14695	COG2234	aminopeptidase activity
G4H71_RS14705	COG0351	phosphomethylpyrimidine kinase
G4H71_RS14725	COG2268	Band 7 protein
G4H71_RS14735	COG0454	-acetyltransferase
G4H71_RS14735	COG0456	acetyltransferase
G4H71_RS14755	COG2032	superoxide dismutase activity
G4H71_RS14760	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4H71_RS14780	COG0651	ATP synthesis coupled electron transport
G4H71_RS14790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4H71_RS14790	COG2111	Na H antiporter
G4H71_RS14795	COG0494	nUDIX hydrolase
G4H71_RS14815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4H71_RS14850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4H71_RS14870	COG0459	protein refolding
G4H71_RS14890	COG2801	Transposase and inactivated derivatives
G4H71_RS14895	COG5433	transposase activity
G4H71_RS14930	COG1505	serine-type exopeptidase activity
G4H71_RS14970	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS15040	COG0683	leucine binding
G4H71_RS15075	COG2224	Isocitrate lyase
G4H71_RS15085	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G4H71_RS15110	COG1064	alcohol dehydrogenase
G4H71_RS15125	COG0297	glycogen (starch) synthase activity
G4H71_RS15140	COG2326	polyphosphate kinase activity
G4H71_RS15155	COG2733	membrane
G4H71_RS15180	COG0789	Transcriptional regulator
G4H71_RS15185	COG2267	carboxylic ester hydrolase activity
G4H71_RS15195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4H71_RS15230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4H71_RS15295	COG5433	transposase activity
G4H71_RS15305	COG0328	RNA-DNA hybrid ribonuclease activity
G4H71_RS15315	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
G4H71_RS15350	COG1468	defense response to virus
G4H71_RS15350	COG1518	maintenance of DNA repeat elements
G4H71_RS15410	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4H71_RS15415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4H71_RS15475	COG0438	transferase activity, transferring glycosyl groups
G4H71_RS15485	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS15490	COG0789	Transcriptional regulator
G4H71_RS15495	COG0667	Aldo Keto reductase
G4H71_RS15500	COG1132	(ABC) transporter
G4H71_RS15505	COG4988	ABC transporter
G4H71_RS15535	COG1770	oligopeptidase
G4H71_RS15560	COG5002	protein histidine kinase activity
G4H71_RS15565	COG0745	RESPONSE REGULATOR receiver
G4H71_RS15645	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4H71_RS15650	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4H71_RS15655	COG0181	hydroxymethylbilane synthase activity
G4H71_RS15660	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4H71_RS15660	COG1587	Uroporphyrinogen-III synthase
G4H71_RS15700	COG0406	alpha-ribazole phosphatase activity
G4H71_RS15710	COG0785	Cytochrome C biogenesis protein
G4H71_RS15715	COG1333	cytochrome c biogenesis protein
G4H71_RS15720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4H71_RS15765	COG0542	response to heat
G4H71_RS15770	COG1950	PFAM Membrane protein of
G4H71_RS15880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4H71_RS15900	COG4948	Mandelate Racemase Muconate Lactonizing
G4H71_RS15915	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
G4H71_RS15925	COG0438	transferase activity, transferring glycosyl groups
G4H71_RS15945	COG0142	geranyltranstransferase activity
G4H71_RS15950	COG0501	Belongs to the peptidase M48B family
G4H71_RS15955	COG1666	GTP binding
G4H71_RS15980	COG2030	dehydratase
G4H71_RS15985	COG2030	dehydratase
G4H71_RS16010	COG0081	regulation of translation
G4H71_RS16030	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS16035	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS16060	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
G4H71_RS16080	COG0085	RNA polymerase activity
G4H71_RS16085	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4H71_RS16110	COG3321	synthase
G4H71_RS16110	COG0604	alcohol dehydrogenase
G4H71_RS16110	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS16135	COG1028	Short-chain dehydrogenase reductase Sdr
G4H71_RS16150	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS16155	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4H71_RS16170	COG1024	Enoyl-CoA hydratase
G4H71_RS16195	COG0049	tRNA binding
G4H71_RS16230	COG1302	Protein conserved in bacteria
G4H71_RS16240	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4H71_RS16250	COG2135	peptidase activity
G4H71_RS16270	COG1131	(ABC) transporter
G4H71_RS16275	COG3559	Exporter of polyketide antibiotics
G4H71_RS16290	COG0535	radical SAM domain protein
G4H71_RS16305	COG0446	pyridine nucleotide-disulphide oxidoreductase
G4H71_RS16305	COG1902	pentaerythritol trinitrate reductase activity
G4H71_RS16360	COG0531	amino acid
G4H71_RS16365	COG4303	Ethanolamine ammonia lyase large subunit
G4H71_RS16405	COG0277	FAD linked oxidase domain protein
G4H71_RS16425	COG0477	Major facilitator Superfamily
G4H71_RS16430	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS16440	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4H71_RS16450	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS16455	COG2030	dehydratase
G4H71_RS16465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4H71_RS16475	COG0287	Prephenate dehydrogenase
G4H71_RS16480	COG0512	Glutamine amidotransferase of anthranilate synthase
G4H71_RS16480	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4H71_RS16490	COG1309	transcriptional regulator
G4H71_RS16510	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS16530	COG0183	Belongs to the thiolase family
G4H71_RS16535	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4H71_RS16535	COG1024	Enoyl-CoA hydratase
G4H71_RS16605	COG1309	transcriptional regulator
G4H71_RS16610	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS16615	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4H71_RS16680	COG0051	transcription antitermination factor activity, RNA binding
G4H71_RS16690	COG0088	Forms part of the polypeptide exit tunnel
G4H71_RS16700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4H71_RS16705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4H71_RS16740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4H71_RS16745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4H71_RS16765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4H71_RS16790	COG0563	adenylate kinase activity
G4H71_RS16805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS16815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS16825	COG1490	D-aminoacyl-tRNA deacylase activity
G4H71_RS16835	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4H71_RS16840	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4H71_RS16845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4H71_RS16860	COG0202	RNA polymerase activity
G4H71_RS16870	COG0101	tRNA pseudouridine synthase activity
G4H71_RS16875	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS16905	COG1404	Belongs to the peptidase S8 family
G4H71_RS16915	COG1674	ftsk spoiiie
G4H71_RS16935	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4H71_RS16970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4H71_RS17000	COG0456	acetyltransferase
G4H71_RS17005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4H71_RS17020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4H71_RS17025	COG0459	protein refolding
G4H71_RS17040	COG5433	transposase activity
G4H71_RS17075	COG0516	GMP reductase activity
G4H71_RS17085	COG0518	GMP synthase (glutamine-hydrolyzing) activity
G4H71_RS17085	COG0519	Catalyzes the synthesis of GMP from XMP
G4H71_RS17120	COG0477	Major facilitator Superfamily
G4H71_RS17150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4H71_RS17200	COG4221	oxidoreductase activity
G4H71_RS17215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4H71_RS17220	COG1120	ATPase activity
G4H71_RS17245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS17250	COG1396	sequence-specific DNA binding
G4H71_RS17250	COG3800	Transcriptional regulator
G4H71_RS17255	COG2079	MmgE PrpD family protein
G4H71_RS17260	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
G4H71_RS17275	COG1733	regulation of RNA biosynthetic process
G4H71_RS17305	COG2076	Multidrug Resistance protein
G4H71_RS17310	COG0587	DNA-directed DNA polymerase activity
G4H71_RS17330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G4H71_RS17345	COG0402	S-adenosylhomocysteine deaminase activity
G4H71_RS17350	COG1609	Transcriptional regulator
G4H71_RS17360	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4H71_RS17370	COG4335	DNA alkylation repair
G4H71_RS17385	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4H71_RS17390	COG2873	o-acetylhomoserine
G4H71_RS17405	COG2814	Major facilitator Superfamily
G4H71_RS17410	COG0708	Exodeoxyribonuclease III
G4H71_RS17415	COG0180	Tryptophanyl-tRNA synthetase
G4H71_RS17420	COG1295	ribonuclease BN
G4H71_RS17435	COG1686	Belongs to the peptidase S11 family
G4H71_RS17440	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G4H71_RS17445	COG1053	succinate dehydrogenase
G4H71_RS17455	COG2009	succinate dehydrogenase
G4H71_RS17490	COG0791	NLP P60 protein
G4H71_RS17500	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G4H71_RS17505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G4H71_RS17525	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4H71_RS17525	COG1473	amidohydrolase
G4H71_RS17530	COG2223	nitrite transmembrane transporter activity
G4H71_RS17545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS17550	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
G4H71_RS17565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4H71_RS17570	COG1201	RNA secondary structure unwinding
G4H71_RS17575	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS17585	COG1522	sequence-specific DNA binding
G4H71_RS17615	COG4770	biotin carboxylase activity
G4H71_RS17645	COG0477	Major facilitator Superfamily
G4H71_RS17660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
G4H71_RS17665	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G4H71_RS17665	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G4H71_RS17675	COG0745	RESPONSE REGULATOR receiver
G4H71_RS17680	COG2205	protein histidine kinase activity
G4H71_RS17690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
G4H71_RS17700	COG4585	Histidine kinase
G4H71_RS17705	COG2197	response regulator
G4H71_RS17710	COG0577	efflux transmembrane transporter activity
G4H71_RS17710	COG1136	(ABC) transporter
G4H71_RS17715	COG1136	(ABC) transporter
G4H71_RS17715	COG0577	efflux transmembrane transporter activity
G4H71_RS17725	COG1316	TRANSCRIPTIONal
G4H71_RS17730	COG1091	dTDP-4-dehydrorhamnose reductase activity
G4H71_RS17770	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4H71_RS17770	COG0778	Nitroreductase
G4H71_RS17800	COG1482	cell wall glycoprotein biosynthetic process
G4H71_RS17810	COG0531	amino acid
G4H71_RS17830	COG0745	RESPONSE REGULATOR receiver
G4H71_RS17835	COG5002	protein histidine kinase activity
G4H71_RS17840	COG5401	PFAM Sporulation and spore germination
G4H71_RS17850	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G4H71_RS17865	COG1011	Hydrolase
G4H71_RS17895	COG1162	GTPase activity
G4H71_RS17900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4H71_RS17905	COG2135	peptidase activity
G4H71_RS17910	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G4H71_RS17925	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
G4H71_RS17940	COG1597	lipid kinase activity
G4H71_RS17955	COG0406	alpha-ribazole phosphatase activity
G4H71_RS17960	COG1192	Involved in chromosome partitioning
G4H71_RS17970	COG0513	Belongs to the DEAD box helicase family
G4H71_RS18010	COG2186	Transcriptional regulator
G4H71_RS18025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4H71_RS18025	COG2146	nitrite reductase [NAD(P)H] activity
G4H71_RS18045	COG0746	molybdenum cofactor guanylyltransferase activity
G4H71_RS18050	COG1309	transcriptional regulator
G4H71_RS18060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
G4H71_RS18070	COG0596	Alpha beta hydrolase
G4H71_RS18075	COG0210	DNA helicase
G4H71_RS18090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4H71_RS18135	COG3480	Lon protease (S16) C-terminal proteolytic domain
G4H71_RS18155	COG1388	LysM domain
G4H71_RS18175	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS18200	COG2378	regulation of single-species biofilm formation
G4H71_RS18205	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS18220	COG0483	inositol monophosphate 1-phosphatase activity
G4H71_RS18235	COG0668	transmembrane transport
G4H71_RS18245	COG2884	Cell division ATP-binding protein ftsE
G4H71_RS18250	COG2177	Part of the ABC transporter FtsEX involved in
G4H71_RS18255	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4H71_RS18275	COG0492	ferredoxin-NADP+ reductase activity
G4H71_RS18275	COG3118	belongs to the thioredoxin family
G4H71_RS18365	COG0477	Major facilitator Superfamily
G4H71_RS18380	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4H71_RS18385	COG0805	protein transport
G4H71_RS18390	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4H71_RS18405	COG1309	transcriptional regulator
G4H71_RS18415	COG0318	PFAM AMP-dependent synthetase and ligase
G4H71_RS18420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4H71_RS18425	COG0523	cobalamin synthesis protein
G4H71_RS18430	COG0778	Nitroreductase
G4H71_RS18435	COG0513	Belongs to the DEAD box helicase family
G4H71_RS18445	COG0315	cyclic pyranopterin monophosphate synthase activity
G4H71_RS18445	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4H71_RS18485	COG1309	transcriptional regulator
G4H71_RS18500	COG0653	protein targeting
G4H71_RS18535	COG1780	Probably involved in ribonucleotide reductase function
G4H71_RS18540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G4H71_RS18555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4H71_RS18560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
G4H71_RS18565	COG3830	Belongs to the UPF0237 family
G4H71_RS18565	COG0560	Phosphoserine phosphatase
G4H71_RS18575	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
G4H71_RS18585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
G4H71_RS18595	COG1119	ATPase activity
G4H71_RS18610	COG2226	methyltransferase
G4H71_RS18620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4H71_RS18625	COG0110	maltose O-acetyltransferase activity
G4H71_RS18640	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
G4H71_RS18650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
G4H71_RS18680	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4H71_RS18700	COG0154	amidase activity
G4H71_RS18715	COG4585	Histidine kinase
G4H71_RS18720	COG2197	response regulator
G4H71_RS18725	COG0205	6-phosphofructokinase activity
G4H71_RS18730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4H71_RS18745	COG0129	dihydroxy-acid dehydratase activity
G4H71_RS18760	COG0440	acetolactate synthase activity
G4H71_RS18765	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4H71_RS18780	COG2271	Major facilitator Superfamily
G4H71_RS18785	COG0179	Fumarylacetoacetate (FAA) hydrolase
G4H71_RS18790	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4H71_RS18815	COG1414	Transcriptional regulator
G4H71_RS18820	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4H71_RS18825	COG0066	3-isopropylmalate dehydratase activity
G4H71_RS18835	COG0406	alpha-ribazole phosphatase activity
G4H71_RS18835	COG0494	nUDIX hydrolase
G4H71_RS18840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
G4H71_RS18845	COG1920	GTP binding
G4H71_RS18850	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4H71_RS18855	COG0626	cystathionine gamma-synthase activity
G4H71_RS18880	COG1024	Enoyl-CoA hydratase
G4H71_RS18885	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4H71_RS18890	COG1461	Dihydroxyacetone kinase
G4H71_RS18895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4H71_RS18905	COG0742	ribosomal rna small subunit methyltransferase
G4H71_RS18925	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4H71_RS18935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4H71_RS18955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
G4H71_RS19005	COG1254	Belongs to the acylphosphatase family
G4H71_RS19010	COG1196	nuclear chromosome segregation
G4H71_RS19030	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G4H71_RS19060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4H71_RS19065	COG0336	Belongs to the RNA methyltransferase TrmD family
G4H71_RS19095	COG0681	Belongs to the peptidase S26 family
G4H71_RS19100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4H71_RS19110	COG1309	transcriptional regulator
G4H71_RS19115	COG1132	(ABC) transporter
G4H71_RS19120	COG1316	TRANSCRIPTIONal
G4H71_RS19135	COG0792	nuclease activity
G4H71_RS19180	COG1752	Esterase of the alpha-beta hydrolase superfamily
G4H71_RS19200	COG0052	Belongs to the universal ribosomal protein uS2 family
G4H71_RS19205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4H71_RS19210	COG0528	UMP kinase activity
G4H71_RS19215	COG0233	cytoplasmic translational termination
G4H71_RS19220	COG0575	Belongs to the CDS family
G4H71_RS19225	COG2226	methyltransferase
G4H71_RS19230	COG2301	Belongs to the HpcH HpaI aldolase family
G4H71_RS19240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4H71_RS19255	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4H71_RS19280	COG2197	response regulator
G4H71_RS19285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4H71_RS19305	COG1131	(ABC) transporter
G4H71_RS19310	COG2188	Transcriptional regulator
G4H71_RS19330	COG0579	oxidoreductase
G4H71_RS19360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4H71_RS19360	COG1648	precorrin-2 dehydrogenase activity
G4H71_RS19370	COG1959	2 iron, 2 sulfur cluster binding
G4H71_RS19375	COG1017	nitric oxide dioxygenase activity
G4H71_RS19375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
G4H71_RS19385	COG3022	response to hydroperoxide
G4H71_RS19390	COG0442	prolyl-tRNA aminoacylation
G4H71_RS19395	COG4122	O-methyltransferase activity
G4H71_RS19425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4H71_RS19440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4H71_RS19450	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4H71_RS19460	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4H71_RS19485	COG1185	polyribonucleotide nucleotidyltransferase activity
G4H71_RS19490	COG2264	protein methyltransferase activity
G4H71_RS19505	COG1140	nitrate reductase beta subunit
G4H71_RS19535	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4H71_RS19550	COG3214	Protein conserved in bacteria
G4H71_RS19570	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G4H71_RS19580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G4H71_RS19595	COG1674	ftsk spoiiie
G4H71_RS19610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4H71_RS19625	COG1396	sequence-specific DNA binding
G4H71_RS19630	COG1842	Phage shock protein A
G4H71_RS19640	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
G4H71_RS19645	COG1122	ATPase activity
G4H71_RS19650	COG1268	BioY protein
G4H71_RS19660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
G4H71_RS19675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4H71_RS19680	COG2137	regulation of response to DNA damage stimulus
G4H71_RS19690	COG0765	amino acid transport
G4H71_RS19695	COG0765	amino acid transport
G4H71_RS19700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G4H71_RS19705	COG1126	abc transporter atp-binding protein
G4H71_RS19725	COG1196	nuclear chromosome segregation
G4H71_RS19735	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4H71_RS19750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
G4H71_RS19765	COG1012	belongs to the aldehyde dehydrogenase family
G4H71_RS19770	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G4H71_RS19780	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4H71_RS19780	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4H71_RS19780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
G4H71_RS19785	COG1105	Belongs to the carbohydrate kinase PfkB family
G4H71_RS19790	COG1349	DNA-binding transcription factor activity
G4H71_RS19795	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4H71_RS19800	COG2233	PERMEase
G4H71_RS19805	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS19815	COG0110	maltose O-acetyltransferase activity
G4H71_RS19830	COG1643	Atp-dependent helicase
G4H71_RS19865	COG1388	LysM domain
G4H71_RS19885	COG0450	alkyl hydroperoxide reductase
G4H71_RS19915	COG0410	ABC transporter
G4H71_RS19925	COG1022	Amp-dependent synthetase and ligase
G4H71_RS19975	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4H71_RS19990	COG2890	protein-(glutamine-N5) methyltransferase activity
G4H71_RS20030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
G4H71_RS20035	COG1960	acyl-CoA dehydrogenase activity
G4H71_RS20040	COG0477	Major facilitator Superfamily
G4H71_RS20045	COG0583	DNA-binding transcription factor activity
G4H71_RS20080	COG0756	dUTP diphosphatase activity
G4H71_RS20110	COG0569	domain protein
G4H71_RS20115	COG0531	amino acid
G4H71_RS20120	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4H71_RS20135	COG2066	Belongs to the glutaminase family
G4H71_RS20135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
G4H71_RS20140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4H71_RS20145	COG0477	Major facilitator Superfamily
G4H71_RS20150	COG4592	Periplasmic binding protein
G4H71_RS20180	COG0745	RESPONSE REGULATOR receiver
G4H71_RS20185	COG0642	Histidine kinase
G4H71_RS20190	COG0390	transport system, permease component
G4H71_RS20195	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4H71_RS20215	COG2826	transposase and inactivated derivatives, IS30 family
G4H71_RS20245	COG0009	L-threonylcarbamoyladenylate synthase
G4H71_RS20255	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G4H71_RS20260	COG3002	Belongs to the UPF0753 family
G4H71_RS20280	COG3328	transposase activity
G4H71_RS20300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G4H71_RS20355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4H71_RS20370	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
G4H71_RS20375	COG3209	COG3209 Rhs family protein
G4H71_RS20385	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
G4H71_RS20410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G4H71_RS20465	COG1250	3-hydroxyacyl-CoA dehydrogenase
G4H71_RS20465	COG1024	Enoyl-CoA hydratase
G4H71_RS20470	COG0183	Belongs to the thiolase family
G4H71_RS20475	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
G4H71_RS20485	COG0657	acetylesterase activity
G4H71_RS20495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G4H71_RS20505	COG3253	May function as heme-dependent peroxidase
G4H71_RS20520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
G4H71_RS20595	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4H71_RS20610	COG1560	Kdo2-lipid A biosynthetic process
G4H71_RS20615	COG0438	transferase activity, transferring glycosyl groups
G4H71_RS20620	COG1051	belongs to the nudix hydrolase family
G4H71_RS20625	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
G4H71_RS20630	COG1946	Acyl-CoA thioesterase
G4H71_RS20645	COG1946	Acyl-CoA thioesterase
G4H71_RS20650	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
G4H71_RS20680	COG2255	four-way junction helicase activity
G4H71_RS20695	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4H71_RS20700	COG0747	negative chemotaxis
G4H71_RS20710	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G4H71_RS20720	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G4H71_RS20750	COG1309	transcriptional regulator
G4H71_RS20780	COG1846	Transcriptional regulator
G4H71_RS20825	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4H71_RS20840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4H71_RS20855	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4H71_RS20870	COG0006	proline dipeptidase activity
G4H71_RS20875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4H71_RS20880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4H71_RS20890	COG0540	Belongs to the ATCase OTCase family
G4H71_RS20905	COG0505	Belongs to the CarA family
G4H71_RS20910	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4H71_RS20925	COG0194	GDP metabolic process
G4H71_RS20930	COG1758	RNA polymerase activity
G4H71_RS20940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4H71_RS20960	COG1305	Transglutaminase-like
G4H71_RS20975	COG0598	Magnesium transport protein CorA
G4H71_RS20995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4H71_RS20995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4H71_RS21010	COG0322	excinuclease ABC activity
G4H71_RS21030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4H71_RS21035	COG0126	phosphoglycerate kinase activity
G4H71_RS21040	COG0149	triose-phosphate isomerase activity
G4H71_RS21050	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
G4H71_RS21075	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4H71_RS21085	COG0109	protoheme IX farnesyltransferase activity
G4H71_RS21115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
G4H71_RS21150	COG0396	ATPase activity
G4H71_RS21160	COG0822	iron-sulfur transferase activity
G4H71_RS21165	COG2151	metal-sulfur cluster biosynthetic enzyme
G4H71_RS21180	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
G4H71_RS21190	COG0488	(ABC) transporter
G4H71_RS21200	COG1309	transcriptional regulator
G4H71_RS21205	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
G4H71_RS21215	COG0791	NLP P60 protein
G4H71_RS21215	COG3883	PFAM NLP P60 protein
G4H71_RS21220	COG0714	Associated with various cellular activities
G4H71_RS21230	COG2304	oxidoreductase activity
G4H71_RS21240	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G4H71_RS21245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G4H71_RS21315	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
G4H71_RS21340	COG1253	flavin adenine dinucleotide binding
G4H71_RS21345	COG1253	flavin adenine dinucleotide binding
G4H71_RS21355	COG0697	spore germination
G4H71_RS21360	COG0513	Belongs to the DEAD box helicase family
G4H71_RS21365	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
G4H71_RS21385	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
G4H71_RS21390	COG1120	ATPase activity
G4H71_RS21395	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4H71_RS21410	COG1252	NADH dehydrogenase
G4H71_RS21435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
G4H71_RS21440	COG4941	Belongs to the sigma-70 factor family
G4H71_RS21450	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4H71_RS21495	COG2267	carboxylic ester hydrolase activity
G4H71_RS21515	COG2319	Wd-40 repeat
G4H71_RS21515	COG4249	Peptidase C14 caspase catalytic subunit p20
G4H71_RS21540	COG0463	Glycosyl transferase, family 2
G4H71_RS21550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
G4H71_RS21565	COG2197	response regulator
G4H71_RS21575	COG4585	Histidine kinase
G4H71_RS21595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4H71_RS21630	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4H71_RS21660	COG0477	Major facilitator Superfamily
G4H71_RS21670	COG2890	protein-(glutamine-N5) methyltransferase activity
G4H71_RS21685	COG1309	transcriptional regulator
G4H71_RS21710	COG4592	Periplasmic binding protein
G4H71_RS21715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4H71_RS21715	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
G4H71_RS21735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
G4H71_RS21785	COG1357	PFAM Pentapeptide repeats (8 copies)
G4H71_RS21790	COG0366	Alpha amylase catalytic
G4H71_RS21795	COG3281	Trehalose synthase
G4H71_RS21835	COG2378	regulation of single-species biofilm formation
G4H71_RS21845	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G4H71_RS21855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
G4H71_RS21880	COG1222	aaa ATPase
G4H71_RS21900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4H71_RS21915	COG0564	pseudouridine synthase activity
G4H71_RS21920	COG1054	Belongs to the UPF0176 family
G4H71_RS21925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4H71_RS21930	COG1410	methionine synthase
G4H71_RS21930	COG0646	methionine synthase
G4H71_RS21985	COG1968	undecaprenyl-diphosphatase activity
G4H71_RS21990	COG0667	Aldo Keto reductase
G4H71_RS22020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G4H71_RS22045	COG3268	Saccharopine dehydrogenase
G4H71_RS22050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
G4H71_RS22060	COG1408	metallophosphoesterase
G4H71_RS22085	COG1716	ATPase activity
G4H71_RS22115	COG0494	nUDIX hydrolase
G4H71_RS22135	COG2072	flavoprotein involved in K transport
G4H71_RS22150	COG2207	Transcriptional regulator
G4H71_RS22170	COG3708	Transcriptional regulator
G4H71_RS22170	COG2207	Transcriptional regulator
G4H71_RS22175	COG0469	pyruvate kinase activity
G4H71_RS22210	COG2801	Transposase and inactivated derivatives
G4H71_RS22215	COG2963	transposase activity
G4H71_RS22240	COG1160	GTP binding
G4H71_RS22245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4H71_RS22250	COG1187	pseudouridine synthase activity
G4H71_RS22255	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4H71_RS22275	COG0494	nUDIX hydrolase
G4H71_RS22320	COG0647	UMP catabolic process