locus-tag	class	description
EXZ61_RS00020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
EXZ61_RS00035	COG1408	metallophosphoesterase
EXZ61_RS00040	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
EXZ61_RS00045	COG2894	cell division
EXZ61_RS00050	COG0850	regulation of cytokinetic process
EXZ61_RS00095	COG2974	May be involved in recombination
EXZ61_RS00125	COG0789	Transcriptional regulator
EXZ61_RS00140	COG2217	Heavy metal translocating P-type atpase
EXZ61_RS00145	COG0124	histidyl-tRNA synthetase
EXZ61_RS00150	COG0840	transmembrane signaling receptor activity
EXZ61_RS00160	COG0840	transmembrane signaling receptor activity
EXZ61_RS00165	COG0625	glutathione transferase activity
EXZ61_RS00180	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS00190	COG0445	tRNA wobble uridine modification
EXZ61_RS00195	COG0357	Ribosomal RNA small subunit methyltransferase G
EXZ61_RS00205	COG1192	Involved in chromosome partitioning
EXZ61_RS00215	COG1475	DNA binding
EXZ61_RS00225	COG3437	response regulator, receiver
EXZ61_RS00235	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXZ61_RS00260	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXZ61_RS00265	COG1802	Transcriptional regulator
EXZ61_RS00285	COG0784	Response regulator, receiver
EXZ61_RS00285	COG5002	protein histidine kinase activity
EXZ61_RS00315	COG3501	Rhs element vgr protein
EXZ61_RS00340	COG0277	FAD linked oxidase domain protein
EXZ61_RS00350	COG2096	Adenosyltransferase
EXZ61_RS00360	COG2050	protein possibly involved in aromatic compounds catabolism
EXZ61_RS00365	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
EXZ61_RS00370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXZ61_RS00375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXZ61_RS00380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXZ61_RS00445	COG1231	oxidoreductase activity
EXZ61_RS00455	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
EXZ61_RS00460	COG4208	sulfate ABC transporter
EXZ61_RS00470	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
EXZ61_RS00480	COG1959	2 iron, 2 sulfur cluster binding
EXZ61_RS00490	COG0697	spore germination
EXZ61_RS00535	COG1174	glycine betaine transport
EXZ61_RS00540	COG1125	glycine betaine transport
EXZ61_RS00545	COG1174	glycine betaine transport
EXZ61_RS00550	COG1732	Glycine betaine
EXZ61_RS00575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXZ61_RS00585	COG4804	nuclease activity
EXZ61_RS00595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXZ61_RS00615	COG1879	ABC-type sugar transport system periplasmic component
EXZ61_RS00645	COG0861	Integral membrane protein TerC family
EXZ61_RS00665	COG2130	NADP-dependent
EXZ61_RS00685	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
EXZ61_RS00710	COG1744	ABC transporter substrate-binding protein PnrA-like
EXZ61_RS00725	COG0167	dihydroorotate dehydrogenase activity
EXZ61_RS00730	COG0493	'glutamate synthase
EXZ61_RS00770	COG4682	membrane
EXZ61_RS00805	COG3842	ATPase activity
EXZ61_RS00830	COG0583	DNA-binding transcription factor activity
EXZ61_RS00845	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXZ61_RS00855	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS00865	COG1802	Transcriptional regulator
EXZ61_RS00870	COG1840	ABC-type Fe3 transport system, periplasmic component
EXZ61_RS00875	COG3842	ATPase activity
EXZ61_RS00885	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
EXZ61_RS00900	COG0174	glutamine synthetase
EXZ61_RS00915	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
EXZ61_RS00920	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS00930	COG2188	Transcriptional regulator
EXZ61_RS00940	COG2205	protein histidine kinase activity
EXZ61_RS00960	COG1175	transmembrane transport
EXZ61_RS00965	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS00970	COG3842	ATPase activity
EXZ61_RS00975	COG2971	BadF BadG BcrA BcrD
EXZ61_RS01010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
EXZ61_RS01010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
EXZ61_RS01020	COG0642	Histidine kinase
EXZ61_RS01035	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
EXZ61_RS01040	COG2137	regulation of response to DNA damage stimulus
EXZ61_RS01045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
EXZ61_RS01050	COG0045	succinate-CoA ligase (ADP-forming) activity
EXZ61_RS01055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
EXZ61_RS01060	COG0861	Integral membrane protein TerC family
EXZ61_RS01065	COG2815	serine threonine protein kinase
EXZ61_RS01065	COG0515	serine threonine protein kinase
EXZ61_RS01070	COG0631	protein serine/threonine phosphatase activity
EXZ61_RS01085	COG1234	tRNA 3'-trailer cleavage
EXZ61_RS01090	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXZ61_RS01100	COG4783	chaperone-mediated protein folding
EXZ61_RS01105	COG1950	PFAM Membrane protein of
EXZ61_RS01110	COG0861	Integral membrane protein TerC family
EXZ61_RS01130	COG0625	glutathione transferase activity
EXZ61_RS01135	COG0840	transmembrane signaling receptor activity
EXZ61_RS01140	COG3118	belongs to the thioredoxin family
EXZ61_RS01145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
EXZ61_RS01150	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
EXZ61_RS01155	COG0009	L-threonylcarbamoyladenylate synthase
EXZ61_RS01160	COG4095	Psort location CytoplasmicMembrane, score
EXZ61_RS01165	COG3706	GGDEF domain
EXZ61_RS01180	COG4969	Belongs to the N-Me-Phe pilin family
EXZ61_RS01210	COG2027	D-alanyl-D-alanine carboxypeptidase
EXZ61_RS01220	COG1214	PFAM Peptidase M22, glycoprotease
EXZ61_RS01235	COG0284	orotidine-5'-phosphate decarboxylase activity
EXZ61_RS01250	COG0625	glutathione transferase activity
EXZ61_RS01260	COG0840	transmembrane signaling receptor activity
EXZ61_RS01275	COG0277	FAD linked oxidase domain protein
EXZ61_RS01300	COG4804	nuclease activity
EXZ61_RS01325	COG3550	peptidyl-serine autophosphorylation
EXZ61_RS01355	COG0419	ATPase involved in DNA repair
EXZ61_RS01360	COG0420	3'-5' exonuclease activity
EXZ61_RS01385	COG1741	Belongs to the pirin family
EXZ61_RS01395	COG3046	protein related to deoxyribodipyrimidine photolyase
EXZ61_RS01405	COG0415	Belongs to the DNA photolyase family
EXZ61_RS01430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EXZ61_RS01435	COG1280	lysine exporter protein (LysE YggA)
EXZ61_RS01490	COG1573	uracil-dna glycosylase
EXZ61_RS01495	COG0583	DNA-binding transcription factor activity
EXZ61_RS01525	COG3145	DNA-N1-methyladenine dioxygenase activity
EXZ61_RS01530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXZ61_RS01530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
EXZ61_RS01560	COG3226	Transcriptional regulator
EXZ61_RS01565	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EXZ61_RS01570	COG1944	ATP diphosphatase activity
EXZ61_RS01600	COG5380	lipid catabolic process
EXZ61_RS01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
EXZ61_RS01635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
EXZ61_RS01640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
EXZ61_RS01645	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS01660	COG0826	peptidase U32
EXZ61_RS01680	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXZ61_RS01715	COG2205	protein histidine kinase activity
EXZ61_RS01720	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS01730	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXZ61_RS01735	COG0006	proline dipeptidase activity
EXZ61_RS01745	COG1252	NADH dehydrogenase
EXZ61_RS01770	COG0688	phosphatidylethanolamine metabolic process
EXZ61_RS01800	COG2095	MarC family integral membrane protein
EXZ61_RS01875	COG0343	queuine tRNA-ribosyltransferase activity
EXZ61_RS01895	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
EXZ61_RS01910	COG0697	spore germination
EXZ61_RS01920	COG3920	Histidine kinase
EXZ61_RS01935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
EXZ61_RS01945	COG0018	arginyl-trna synthetase
EXZ61_RS01955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
EXZ61_RS01965	COG1137	ATPase activity
EXZ61_RS01970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
EXZ61_RS01990	COG0069	glutamate synthase activity
EXZ61_RS01995	COG0653	protein targeting
EXZ61_RS02000	COG0583	DNA-binding transcription factor activity
EXZ61_RS02010	COG4191	Histidine kinase
EXZ61_RS02010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS02020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
EXZ61_RS02025	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
EXZ61_RS02040	COG2201	protein-glutamate methylesterase activity
EXZ61_RS02045	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EXZ61_RS02050	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXZ61_RS02055	COG0835	chemotaxis
EXZ61_RS02055	COG0784	Response regulator, receiver
EXZ61_RS02060	COG0840	transmembrane signaling receptor activity
EXZ61_RS02065	COG0835	chemotaxis
EXZ61_RS02070	COG0840	transmembrane signaling receptor activity
EXZ61_RS02085	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS02095	COG0126	phosphoglycerate kinase activity
EXZ61_RS02110	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
EXZ61_RS02115	COG0242	peptide deformylase activity
EXZ61_RS02125	COG0758	DNA mediated transformation
EXZ61_RS02130	COG2922	Belongs to the Smg family
EXZ61_RS02140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXZ61_RS02145	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
EXZ61_RS02150	COG1862	Preprotein translocase
EXZ61_RS02170	COG0835	chemotaxis
EXZ61_RS02170	COG0784	Response regulator, receiver
EXZ61_RS02175	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
EXZ61_RS02190	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
EXZ61_RS02195	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
EXZ61_RS02205	COG0625	glutathione transferase activity
EXZ61_RS02215	COG1309	transcriptional regulator
EXZ61_RS02250	COG2814	Major facilitator Superfamily
EXZ61_RS02255	COG0629	single-stranded DNA binding
EXZ61_RS02315	COG0457	Tetratricopeptide repeat
EXZ61_RS02320	COG1215	transferase activity, transferring glycosyl groups
EXZ61_RS02340	COG0482	sulfurtransferase activity
EXZ61_RS02360	COG0318	PFAM AMP-dependent synthetase and ligase
EXZ61_RS02365	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXZ61_RS02370	COG0598	Magnesium transport protein CorA
EXZ61_RS02375	COG2814	Major facilitator Superfamily
EXZ61_RS02475	COG2842	Transposition protein
EXZ61_RS02490	COG4396	Host-nuclease inhibitor protein Gam
EXZ61_RS02555	COG4386	tail sheath protein
EXZ61_RS02590	COG4381	Mu-like prophage protein gp46
EXZ61_RS02640	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
EXZ61_RS02650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
EXZ61_RS02655	COG0735	belongs to the Fur family
EXZ61_RS02660	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EXZ61_RS02665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
EXZ61_RS02680	COG0495	leucyl-tRNA aminoacylation
EXZ61_RS02690	COG1737	Transcriptional regulator
EXZ61_RS02715	COG4160	amino acid transport
EXZ61_RS02745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
EXZ61_RS02745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
EXZ61_RS02790	COG4221	oxidoreductase activity
EXZ61_RS02805	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
EXZ61_RS02815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
EXZ61_RS02840	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
EXZ61_RS02845	COG3706	GGDEF domain
EXZ61_RS02855	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS02860	COG2205	protein histidine kinase activity
EXZ61_RS02865	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
EXZ61_RS02870	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
EXZ61_RS02875	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
EXZ61_RS02885	COG3158	transport of potassium into the cell
EXZ61_RS02890	COG3135	benzoate transporter
EXZ61_RS02895	COG0189	ligase activity
EXZ61_RS02910	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXZ61_RS02920	COG0121	glutamine amidotransferase
EXZ61_RS02925	COG1942	4-Oxalocrotonate Tautomerase
EXZ61_RS02955	COG1764	response to oxidative stress
EXZ61_RS02960	COG1846	Transcriptional regulator
EXZ61_RS02990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EXZ61_RS03000	COG0842	Transport permease protein
EXZ61_RS03005	COG1131	(ABC) transporter
EXZ61_RS03010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
EXZ61_RS03030	COG2954	triphosphatase activity
EXZ61_RS03055	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
EXZ61_RS03120	COG2072	flavoprotein involved in K transport
EXZ61_RS03125	COG0300	oxidoreductase activity
EXZ61_RS03130	COG1414	Transcriptional regulator
EXZ61_RS03155	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EXZ61_RS03170	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
EXZ61_RS03180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXZ61_RS03200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
EXZ61_RS03205	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
EXZ61_RS03210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
EXZ61_RS03215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
EXZ61_RS03220	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
EXZ61_RS03225	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
EXZ61_RS03230	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
EXZ61_RS03235	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
EXZ61_RS03240	COG1841	ribosomal large subunit assembly
EXZ61_RS03245	COG0200	Binds to the 23S rRNA
EXZ61_RS03250	COG0201	protein transport
EXZ61_RS03255	COG0257	Belongs to the bacterial ribosomal protein bL36 family
EXZ61_RS03260	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
EXZ61_RS03265	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
EXZ61_RS03270	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
EXZ61_RS03275	COG0202	RNA polymerase activity
EXZ61_RS03280	COG0203	ribosomal protein L17
EXZ61_RS03305	COG0400	carboxylic ester hydrolase activity
EXZ61_RS03315	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EXZ61_RS03320	COG0830	nickel cation binding
EXZ61_RS03325	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
EXZ61_RS03330	COG0804	urea catabolic process
EXZ61_RS03335	COG0832	Belongs to the urease beta subunit family
EXZ61_RS03345	COG0831	urea catabolic process
EXZ61_RS03370	COG2353	YceI-like domain
EXZ61_RS03375	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
EXZ61_RS03380	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXZ61_RS03385	COG0473	3-isopropylmalate dehydrogenase activity
EXZ61_RS03390	COG0583	DNA-binding transcription factor activity
EXZ61_RS03400	COG4133	protoheme IX ABC transporter activity
EXZ61_RS03455	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS03470	COG1476	TRANSCRIPTIONal
EXZ61_RS03480	COG2897	thiosulfate sulfurtransferase activity
EXZ61_RS03510	COG0829	nickel cation binding
EXZ61_RS03515	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
EXZ61_RS03525	COG2423	ornithine cyclodeaminase activity
EXZ61_RS03600	COG4191	Histidine kinase
EXZ61_RS03605	COG3275	phosphorelay sensor kinase activity
EXZ61_RS03620	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
EXZ61_RS03630	COG3300	MHYT domain
EXZ61_RS03630	COG5001	Diguanylate cyclase
EXZ61_RS03635	COG0515	serine threonine protein kinase
EXZ61_RS03635	COG2815	serine threonine protein kinase
EXZ61_RS03665	COG2268	Band 7 protein
EXZ61_RS03670	COG0583	DNA-binding transcription factor activity
EXZ61_RS03675	COG3960	tartronate-semialdehyde synthase activity
EXZ61_RS03680	COG3622	Belongs to the hyi family
EXZ61_RS03685	COG2084	Dehydrogenase
EXZ61_RS03690	COG0469	pyruvate kinase activity
EXZ61_RS03695	COG3291	Pkd domain containing protein
EXZ61_RS03695	COG4447	cellulose binding
EXZ61_RS03695	COG5520	Belongs to the glycosyl hydrolase 30 family
EXZ61_RS03710	COG2186	Transcriptional regulator
EXZ61_RS03720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXZ61_RS03725	COG0280	phosphate acetyltransferase
EXZ61_RS03725	COG0281	malic enzyme
EXZ61_RS03735	COG2814	Major facilitator Superfamily
EXZ61_RS03740	COG5002	protein histidine kinase activity
EXZ61_RS03745	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS03750	COG1595	DNA-templated transcription, initiation
EXZ61_RS03755	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
EXZ61_RS03760	COG0546	phosphoglycolate phosphatase activity
EXZ61_RS03775	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXZ61_RS03785	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
EXZ61_RS03790	COG2967	ApaG domain
EXZ61_RS03805	COG2866	Carboxypeptidase
EXZ61_RS03830	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
EXZ61_RS03845	COG0583	DNA-binding transcription factor activity
EXZ61_RS03850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXZ61_RS03860	COG0183	Belongs to the thiolase family
EXZ61_RS03865	COG0183	Belongs to the thiolase family
EXZ61_RS03875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXZ61_RS03885	COG0545	Peptidyl-prolyl cis-trans isomerase
EXZ61_RS03890	COG4608	Belongs to the ABC transporter superfamily
EXZ61_RS03895	COG0444	Belongs to the ABC transporter superfamily
EXZ61_RS03900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXZ61_RS03905	COG0601	transmembrane transport
EXZ61_RS03910	COG4166	transmembrane transport
EXZ61_RS03915	COG0326	Molecular chaperone. Has ATPase activity
EXZ61_RS03930	COG1187	pseudouridine synthase activity
EXZ61_RS03950	COG1216	Glycosyl transferase, family 2
EXZ61_RS03950	COG1442	glycosyl transferase family 8
EXZ61_RS03970	COG0489	protein tyrosine kinase activity
EXZ61_RS03980	COG1215	transferase activity, transferring glycosyl groups
EXZ61_RS04000	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS04090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXZ61_RS04095	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS04105	COG1309	transcriptional regulator
EXZ61_RS04115	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS04125	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXZ61_RS04125	COG1024	Enoyl-CoA hydratase
EXZ61_RS04135	COG0183	Belongs to the thiolase family
EXZ61_RS04150	COG1024	Enoyl-CoA hydratase
EXZ61_RS04190	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS04195	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS04205	COG0217	transcriptional regulatory protein
EXZ61_RS04215	COG3706	GGDEF domain
EXZ61_RS04225	COG1607	acyl-coa hydrolase
EXZ61_RS04280	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXZ61_RS04285	COG0559	Belongs to the binding-protein-dependent transport system permease family
EXZ61_RS04290	COG3447	MASE1 domain protein
EXZ61_RS04290	COG5002	protein histidine kinase activity
EXZ61_RS04290	COG5001	Diguanylate cyclase
EXZ61_RS04295	COG1607	acyl-coa hydrolase
EXZ61_RS04300	COG5265	(ABC) transporter
EXZ61_RS04310	COG0596	Alpha beta hydrolase
EXZ61_RS04325	COG3708	Transcriptional regulator
EXZ61_RS04325	COG2207	Transcriptional regulator
EXZ61_RS04360	COG1686	Belongs to the peptidase S11 family
EXZ61_RS04365	COG3284	Transcriptional regulator
EXZ61_RS04370	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS04380	COG0789	Transcriptional regulator
EXZ61_RS04395	COG0583	DNA-binding transcription factor activity
EXZ61_RS04405	COG0418	dihydroorotase activity
EXZ61_RS04415	COG0501	Belongs to the peptidase M48B family
EXZ61_RS04420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXZ61_RS04425	COG1116	anion transmembrane transporter activity
EXZ61_RS04430	COG1280	lysine exporter protein (LysE YggA)
EXZ61_RS04495	COG2165	general secretion pathway protein
EXZ61_RS04510	COG0577	efflux transmembrane transporter activity
EXZ61_RS04510	COG1136	(ABC) transporter
EXZ61_RS04520	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
EXZ61_RS04530	COG1404	Belongs to the peptidase S8 family
EXZ61_RS04550	COG0517	IMP dehydrogenase activity
EXZ61_RS04550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
EXZ61_RS04555	COG2885	chlorophyll binding
EXZ61_RS04555	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
EXZ61_RS04570	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
EXZ61_RS04580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
EXZ61_RS04590	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
EXZ61_RS04595	COG0523	cobalamin synthesis protein
EXZ61_RS04610	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
EXZ61_RS04615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
EXZ61_RS04620	COG2001	Belongs to the MraZ family
EXZ61_RS04625	COG0275	rRNA processing
EXZ61_RS04640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXZ61_RS04645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
EXZ61_RS04650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
EXZ61_RS04655	COG0772	Belongs to the SEDS family
EXZ61_RS04660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
EXZ61_RS04665	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXZ61_RS04670	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXZ61_RS04675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
EXZ61_RS04685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
EXZ61_RS04690	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
EXZ61_RS04695	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
EXZ61_RS04700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
EXZ61_RS04725	COG0069	glutamate synthase activity
EXZ61_RS04725	COG0070	glutamate synthase
EXZ61_RS04725	COG0067	glutamate synthase
EXZ61_RS04735	COG1127	ABC transporter
EXZ61_RS04740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EXZ61_RS04745	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
EXZ61_RS04750	COG2853	Lipoprotein
EXZ61_RS04765	COG1131	(ABC) transporter
EXZ61_RS04770	COG0842	Transport permease protein
EXZ61_RS04775	COG5007	Belongs to the BolA IbaG family
EXZ61_RS04780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
EXZ61_RS04785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
EXZ61_RS04790	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
EXZ61_RS04800	COG0742	ribosomal rna small subunit methyltransferase
EXZ61_RS04805	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
EXZ61_RS04815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
EXZ61_RS04825	COG0193	aminoacyl-tRNA hydrolase activity
EXZ61_RS04830	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
EXZ61_RS04835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
EXZ61_RS04845	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
EXZ61_RS04860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
EXZ61_RS04875	COG1660	Displays ATPase and GTPase activities
EXZ61_RS04880	COG0497	DNA recombination
EXZ61_RS04885	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
EXZ61_RS04890	COG1420	regulation of RNA biosynthetic process
EXZ61_RS04900	COG0582	viral genome integration into host DNA
EXZ61_RS04950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXZ61_RS04955	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS04965	COG4770	biotin carboxylase activity
EXZ61_RS04970	COG3246	L-lysine catabolic process to acetate
EXZ61_RS04985	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXZ61_RS04990	COG1758	RNA polymerase activity
EXZ61_RS04995	COG0194	GDP metabolic process
EXZ61_RS05000	COG1561	YicC-like family, N-terminal region
EXZ61_RS05070	COG0673	inositol 2-dehydrogenase activity
EXZ61_RS05075	COG0673	inositol 2-dehydrogenase activity
EXZ61_RS05105	COG3962	Belongs to the TPP enzyme family
EXZ61_RS05115	COG3718	enzyme involved in inositol metabolism
EXZ61_RS05130	COG2264	protein methyltransferase activity
EXZ61_RS05155	COG0583	DNA-binding transcription factor activity
EXZ61_RS05170	COG0315	cyclic pyranopterin monophosphate synthase activity
EXZ61_RS05185	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
EXZ61_RS05190	COG0575	Belongs to the CDS family
EXZ61_RS05215	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
EXZ61_RS05220	COG3150	esterase
EXZ61_RS05225	COG0772	Belongs to the SEDS family
EXZ61_RS05230	COG0312	modulator of DNA gyrase
EXZ61_RS05235	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EXZ61_RS05240	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
EXZ61_RS05250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXZ61_RS05255	COG0511	ligase activity, forming carbon-carbon bonds
EXZ61_RS05260	COG0439	Biotin carboxylase
EXZ61_RS05265	COG2264	protein methyltransferase activity
EXZ61_RS05280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXZ61_RS05285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
EXZ61_RS05285	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXZ61_RS05310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
EXZ61_RS05320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXZ61_RS05340	COG1024	Enoyl-CoA hydratase
EXZ61_RS05355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXZ61_RS05370	COG0012	GTP binding
EXZ61_RS05375	COG1238	metal cluster binding
EXZ61_RS05380	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXZ61_RS05385	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
EXZ61_RS05390	COG0138	bifunctional purine biosynthesis protein purh
EXZ61_RS05395	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
EXZ61_RS05400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
EXZ61_RS05405	COG0517	IMP dehydrogenase activity
EXZ61_RS05405	COG0617	tRNA 3'-terminal CCA addition
EXZ61_RS05405	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
EXZ61_RS05455	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EXZ61_RS05460	COG0732	type I restriction modification DNA specificity domain
EXZ61_RS05465	COG1401	restriction endodeoxyribonuclease activity
EXZ61_RS05465	COG1401	restriction endodeoxyribonuclease activity
EXZ61_RS05475	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXZ61_RS05535	COG0765	amino acid transport
EXZ61_RS05545	COG4628	conserved protein (DUF2132)
EXZ61_RS05555	COG1653	transport
EXZ61_RS05560	COG1175	transmembrane transport
EXZ61_RS05565	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS05585	COG2222	sugar isomerase
EXZ61_RS05590	COG1940	carbohydrate kinase activity
EXZ61_RS05600	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
EXZ61_RS05610	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS05630	COG0583	DNA-binding transcription factor activity
EXZ61_RS05640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS05660	COG0673	inositol 2-dehydrogenase activity
EXZ61_RS05720	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EXZ61_RS05730	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXZ61_RS05735	COG1979	alcohol dehydrogenase
EXZ61_RS05745	COG3384	dioxygenase
EXZ61_RS05755	COG0784	Response regulator, receiver
EXZ61_RS05755	COG2205	protein histidine kinase activity
EXZ61_RS05755	COG5002	protein histidine kinase activity
EXZ61_RS05770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXZ61_RS05780	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXZ61_RS05790	COG2186	Transcriptional regulator
EXZ61_RS05795	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
EXZ61_RS05800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXZ61_RS05805	COG0784	Response regulator, receiver
EXZ61_RS05805	COG5002	protein histidine kinase activity
EXZ61_RS05805	COG2205	protein histidine kinase activity
EXZ61_RS05810	COG2824	Alkylphosphonate utilization operon protein PhnA
EXZ61_RS05815	COG2890	protein-(glutamine-N5) methyltransferase activity
EXZ61_RS05820	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
EXZ61_RS05825	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
EXZ61_RS05840	COG0584	glycerophosphoryl diester phosphodiesterase
EXZ61_RS05845	COG3842	ATPase activity
EXZ61_RS05850	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS05855	COG1175	transmembrane transport
EXZ61_RS05860	COG1653	transport
EXZ61_RS05875	COG2226	methyltransferase
EXZ61_RS05890	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
EXZ61_RS05905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
EXZ61_RS05910	COG0494	nUDIX hydrolase
EXZ61_RS05920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
EXZ61_RS05925	COG0302	gtp cyclohydrolase
EXZ61_RS05955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
EXZ61_RS05960	COG0793	Belongs to the peptidase S41A family
EXZ61_RS05965	COG0588	phosphoglycerate mutase activity
EXZ61_RS05970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
EXZ61_RS05980	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
EXZ61_RS05985	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
EXZ61_RS05990	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXZ61_RS05990	COG0189	ligase activity
EXZ61_RS05995	COG1181	Belongs to the D-alanine--D-alanine ligase family
EXZ61_RS05995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
EXZ61_RS06000	COG1132	(ABC) transporter
EXZ61_RS06010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
EXZ61_RS06015	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
EXZ61_RS06035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
EXZ61_RS06060	COG0840	transmembrane signaling receptor activity
EXZ61_RS06075	COG0602	queuosine metabolic process
EXZ61_RS06080	COG0625	glutathione transferase activity
EXZ61_RS06085	COG0309	Hydrogenase expression formation protein (HypE)
EXZ61_RS06090	COG0409	Hydrogenase expression formation protein
EXZ61_RS06095	COG0298	carbon dioxide binding
EXZ61_RS06100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
EXZ61_RS06105	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
EXZ61_RS06110	COG0375	protein maturation
EXZ61_RS06120	COG3259	Nickel-dependent hydrogenase
EXZ61_RS06125	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
EXZ61_RS06130	COG3383	formate dehydrogenase (NAD+) activity
EXZ61_RS06135	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
EXZ61_RS06140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
EXZ61_RS06150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXZ61_RS06150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXZ61_RS06165	COG0489	protein tyrosine kinase activity
EXZ61_RS06170	COG0243	molybdopterin cofactor binding
EXZ61_RS06180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
EXZ61_RS06185	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
EXZ61_RS06220	COG2003	Belongs to the UPF0758 family
EXZ61_RS06245	COG2003	Belongs to the UPF0758 family
EXZ61_RS06250	COG1047	Peptidyl-prolyl cis-trans
EXZ61_RS06255	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
EXZ61_RS06260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXZ61_RS06290	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXZ61_RS06295	COG0583	DNA-binding transcription factor activity
EXZ61_RS06300	COG3158	transport of potassium into the cell
EXZ61_RS06305	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS06310	COG2205	protein histidine kinase activity
EXZ61_RS06320	COG2084	Dehydrogenase
EXZ61_RS06330	COG2721	sulfolactate sulfo-lyase activity
EXZ61_RS06345	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EXZ61_RS06355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXZ61_RS06360	COG2186	Transcriptional regulator
EXZ61_RS06365	COG4948	Mandelate Racemase Muconate Lactonizing
EXZ61_RS06390	COG1802	Transcriptional regulator
EXZ61_RS06395	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXZ61_RS06400	COG0174	glutamine synthetase
EXZ61_RS06425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
EXZ61_RS06460	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
EXZ61_RS06465	COG0402	S-adenosylhomocysteine deaminase activity
EXZ61_RS06470	COG0717	Belongs to the dCTP deaminase family
EXZ61_RS06475	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
EXZ61_RS06480	COG0513	Belongs to the DEAD box helicase family
EXZ61_RS06485	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
EXZ61_RS06490	COG1253	flavin adenine dinucleotide binding
EXZ61_RS06495	COG1434	Gram-negative-bacterium-type cell wall biogenesis
EXZ61_RS06515	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
EXZ61_RS06520	COG0308	aminopeptidase N
EXZ61_RS06525	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
EXZ61_RS06535	COG3842	ATPase activity
EXZ61_RS06540	COG1178	ABC-type Fe3 transport system permease component
EXZ61_RS06545	COG1840	ABC-type Fe3 transport system, periplasmic component
EXZ61_RS06555	COG2267	carboxylic ester hydrolase activity
EXZ61_RS06560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXZ61_RS06585	COG0667	Aldo Keto reductase
EXZ61_RS06595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
EXZ61_RS06600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
EXZ61_RS06615	COG1666	GTP binding
EXZ61_RS06620	COG0812	UDP-N-acetylmuramate dehydrogenase activity
EXZ61_RS06625	COG5002	protein histidine kinase activity
EXZ61_RS06625	COG0784	Response regulator, receiver
EXZ61_RS06635	COG0137	argininosuccinate synthase activity
EXZ61_RS06640	COG3123	guanosine phosphorylase activity
EXZ61_RS06645	COG1393	Belongs to the ArsC family
EXZ61_RS06650	COG0285	dihydrofolate synthase activity
EXZ61_RS06660	COG1286	toxin biosynthetic process
EXZ61_RS06675	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXZ61_RS06695	COG0697	spore germination
EXZ61_RS06715	COG0859	PFAM glycosyl transferase family 9
EXZ61_RS06735	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EXZ61_RS06750	COG1309	transcriptional regulator
EXZ61_RS06760	COG1522	sequence-specific DNA binding
EXZ61_RS06765	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXZ61_RS06775	COG0860	N-Acetylmuramoyl-L-alanine amidase
EXZ61_RS06780	COG0802	atpase or kinase
EXZ61_RS06785	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
EXZ61_RS06800	COG3181	Tripartite tricarboxylate transporter family receptor
EXZ61_RS06805	COG4974	Belongs to the 'phage' integrase family
EXZ61_RS06810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EXZ61_RS06815	COG2833	Protein of unknown function (DUF455)
EXZ61_RS06825	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
EXZ61_RS06835	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
EXZ61_RS06840	COG0148	phosphopyruvate hydratase activity
EXZ61_RS06845	COG2877	3-deoxy-8-phosphooctulonate synthase activity
EXZ61_RS06850	COG0504	CTP synthase activity
EXZ61_RS06855	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
EXZ61_RS06860	COG0756	dUTP diphosphatase activity
EXZ61_RS06870	COG2850	peptidyl-arginine hydroxylation
EXZ61_RS06880	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
EXZ61_RS06885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXZ61_RS06910	COG0741	lytic transglycosylase activity
EXZ61_RS06910	COG1196	nuclear chromosome segregation
EXZ61_RS06910	COG0739	heme binding
EXZ61_RS06920	COG0270	DNA (cytosine-5-)-methyltransferase activity
EXZ61_RS06950	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EXZ61_RS06955	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
EXZ61_RS06960	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
EXZ61_RS06965	COG3265	gluconokinase activity
EXZ61_RS06970	COG1309	transcriptional regulator
EXZ61_RS07000	COG2188	Transcriptional regulator
EXZ61_RS07005	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXZ61_RS07010	COG4989	oxidoreductase activity
EXZ61_RS07015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXZ61_RS07030	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS07035	COG1175	transmembrane transport
EXZ61_RS07045	COG0673	inositol 2-dehydrogenase activity
EXZ61_RS07050	COG1063	alcohol dehydrogenase
EXZ61_RS07065	COG3501	Rhs element vgr protein
EXZ61_RS07085	COG1609	Transcriptional regulator
EXZ61_RS07090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
EXZ61_RS07110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
EXZ61_RS07125	COG2066	Belongs to the glutaminase family
EXZ61_RS07145	COG1280	lysine exporter protein (LysE YggA)
EXZ61_RS07150	COG2202	Pas domain
EXZ61_RS07150	COG2200	EAL domain
EXZ61_RS07150	COG2199	diguanylate cyclase activity
EXZ61_RS07165	COG0662	Cupin 2, conserved barrel domain protein
EXZ61_RS07190	COG3483	tryptophan 2,3-dioxygenase activity
EXZ61_RS07210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
EXZ61_RS07215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
EXZ61_RS07225	COG0268	Binds directly to 16S ribosomal RNA
EXZ61_RS07230	COG0728	peptidoglycan biosynthetic process
EXZ61_RS07240	COG1192	Involved in chromosome partitioning
EXZ61_RS07245	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
EXZ61_RS07250	COG0628	permease
EXZ61_RS07255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
EXZ61_RS07265	COG0617	tRNA 3'-terminal CCA addition
EXZ61_RS07270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
EXZ61_RS07275	COG0840	transmembrane signaling receptor activity
EXZ61_RS07295	COG4948	Mandelate Racemase Muconate Lactonizing
EXZ61_RS07300	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS07305	COG4175	Glycine betaine
EXZ61_RS07310	COG4176	ABC-type proline glycine betaine transport system permease component
EXZ61_RS07320	COG0667	Aldo Keto reductase
EXZ61_RS07355	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS07375	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
EXZ61_RS07380	COG0484	heat shock protein binding
EXZ61_RS07385	COG0443	Heat shock 70 kDa protein
EXZ61_RS07390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
EXZ61_RS07425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXZ61_RS07435	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
EXZ61_RS07440	COG1011	Hydrolase
EXZ61_RS07445	COG2366	antibiotic biosynthetic process
EXZ61_RS07450	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
EXZ61_RS07455	COG1562	ergosterol biosynthetic process
EXZ61_RS07470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXZ61_RS07480	COG0544	peptidyl-prolyl cis-trans isomerase activity
EXZ61_RS07485	COG0740	serine-type endopeptidase activity
EXZ61_RS07490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
EXZ61_RS07495	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
EXZ61_RS07530	COG2308	Evidence 4 Homologs of previously reported genes of
EXZ61_RS07545	COG1305	Transglutaminase-like
EXZ61_RS07585	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXZ61_RS07595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
EXZ61_RS07605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
EXZ61_RS07610	COG0252	asparaginase activity
EXZ61_RS07615	COG0563	adenylate kinase activity
EXZ61_RS07620	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
EXZ61_RS07625	COG2835	tetraacyldisaccharide 4'-kinase activity
EXZ61_RS07630	COG1663	tetraacyldisaccharide 4'-kinase activity
EXZ61_RS07635	COG0848	biopolymer transport protein
EXZ61_RS07640	COG0811	peptide transport
EXZ61_RS07645	COG1570	exodeoxyribonuclease VII activity
EXZ61_RS07650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
EXZ61_RS07680	COG1802	Transcriptional regulator
EXZ61_RS07685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXZ61_RS07685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXZ61_RS07695	COG1703	isobutyryl-CoA mutase activity
EXZ61_RS07705	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXZ61_RS07710	COG4770	biotin carboxylase activity
EXZ61_RS07720	COG2878	Part of a membrane complex involved in electron transport
EXZ61_RS07740	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXZ61_RS07745	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXZ61_RS07765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
EXZ61_RS07775	COG2070	2-Nitropropane dioxygenase
EXZ61_RS07780	COG0322	excinuclease ABC activity
EXZ61_RS07800	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXZ61_RS07810	COG1435	thymidine kinase activity
EXZ61_RS07815	COG0671	phosphoesterase, PA-phosphatase related
EXZ61_RS07835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
EXZ61_RS07860	COG2329	Antibiotic biosynthesis monooxygenase
EXZ61_RS07875	COG3243	poly(R)-hydroxyalkanoic acid synthase
EXZ61_RS07880	COG0183	Belongs to the thiolase family
EXZ61_RS07885	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS07935	COG4139	cobalamin transport
EXZ61_RS07940	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EXZ61_RS07965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXZ61_RS07980	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
EXZ61_RS08040	COG2875	Belongs to the precorrin methyltransferase family
EXZ61_RS08055	COG2099	Precorrin-6x reductase
EXZ61_RS08080	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
EXZ61_RS08080	COG1648	precorrin-2 dehydrogenase activity
EXZ61_RS08085	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
EXZ61_RS08090	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EXZ61_RS08100	COG1492	cobalamin metabolic process
EXZ61_RS08105	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
EXZ61_RS08110	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
EXZ61_RS08120	COG1639	'signal transduction protein
EXZ61_RS08125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
EXZ61_RS08130	COG1639	'signal transduction protein
EXZ61_RS08135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS08140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
EXZ61_RS08145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
EXZ61_RS08150	COG0642	Histidine kinase
EXZ61_RS08190	COG1668	transmembrane transport
EXZ61_RS08195	COG4555	ABC transporter
EXZ61_RS08205	COG2204	response regulator
EXZ61_RS08215	COG1131	(ABC) transporter
EXZ61_RS08220	COG0842	Transport permease protein
EXZ61_RS08230	COG0411	ABC transporter
EXZ61_RS08260	COG2233	PERMEase
EXZ61_RS08265	COG0556	nucleotide-excision repair
EXZ61_RS08270	COG1959	2 iron, 2 sulfur cluster binding
EXZ61_RS08275	COG1104	cysteine desulfurase activity
EXZ61_RS08280	COG0822	iron-sulfur transferase activity
EXZ61_RS08290	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
EXZ61_RS08295	COG0443	Heat shock 70 kDa protein
EXZ61_RS08320	COG0604	alcohol dehydrogenase
EXZ61_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS08320	COG3321	synthase
EXZ61_RS08325	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
EXZ61_RS08330	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
EXZ61_RS08345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
EXZ61_RS08355	COG0670	Belongs to the BI1 family
EXZ61_RS08360	COG3193	protein, possibly involved in utilization of glycolate and propanediol
EXZ61_RS08385	COG3128	pkhd-type hydroxylase
EXZ61_RS08455	COG3268	Saccharopine dehydrogenase
EXZ61_RS08460	COG0300	oxidoreductase activity
EXZ61_RS08470	COG4771	TonB-dependent receptor
EXZ61_RS08480	COG3720	iron ion transport
EXZ61_RS08490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
EXZ61_RS08495	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
EXZ61_RS08500	COG3397	chitin binding
EXZ61_RS08515	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
EXZ61_RS08525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
EXZ61_RS08530	COG0360	Binds together with S18 to 16S ribosomal RNA
EXZ61_RS08540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
EXZ61_RS08545	COG0359	binds to the 23S rRNA
EXZ61_RS08550	COG0305	Participates in initiation and elongation during chromosome replication
EXZ61_RS08555	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
EXZ61_RS08560	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
EXZ61_RS08570	COG0436	Aminotransferase
EXZ61_RS08585	COG0303	'Molybdopterin
EXZ61_RS08595	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
EXZ61_RS08600	COG0314	molybdopterin synthase activity
EXZ61_RS08605	COG0542	response to heat
EXZ61_RS08615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXZ61_RS08635	COG0436	Aminotransferase
EXZ61_RS08640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXZ61_RS08645	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
EXZ61_RS08705	COG3328	transposase activity
EXZ61_RS08715	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
EXZ61_RS08720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXZ61_RS08725	COG0741	lytic transglycosylase activity
EXZ61_RS08735	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXZ61_RS08755	COG3063	Type IV pilus biogenesis stability protein PilW
EXZ61_RS08760	COG0215	cysteine-tRNA ligase activity
EXZ61_RS08775	COG0037	tRNA processing
EXZ61_RS08785	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXZ61_RS08800	COG0560	Phosphoserine phosphatase
EXZ61_RS08820	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
EXZ61_RS08825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EXZ61_RS08825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXZ61_RS08830	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
EXZ61_RS08830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
EXZ61_RS08835	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXZ61_RS08835	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS08840	COG2205	protein histidine kinase activity
EXZ61_RS08845	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS08865	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS08870	COG2267	carboxylic ester hydrolase activity
EXZ61_RS08875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
EXZ61_RS08915	COG2207	Transcriptional regulator
EXZ61_RS08920	COG0300	oxidoreductase activity
EXZ61_RS08940	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
EXZ61_RS08945	COG0433	COG0433 Predicted ATPase
EXZ61_RS08950	COG0217	transcriptional regulatory protein
EXZ61_RS08955	COG0151	Belongs to the GarS family
EXZ61_RS08965	COG0408	coproporphyrinogen oxidase activity
EXZ61_RS08970	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
EXZ61_RS08975	COG0799	negative regulation of ribosome biogenesis
EXZ61_RS08980	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
EXZ61_RS08985	COG0424	maF-like protein
EXZ61_RS08990	COG1530	ribonuclease E activity
EXZ61_RS08995	COG0438	transferase activity, transferring glycosyl groups
EXZ61_RS09000	COG1215	transferase activity, transferring glycosyl groups
EXZ61_RS09030	COG1132	(ABC) transporter
EXZ61_RS09045	COG0823	Involved in the tonB-independent uptake of proteins
EXZ61_RS09060	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
EXZ61_RS09085	COG0052	Belongs to the universal ribosomal protein uS2 family
EXZ61_RS09090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
EXZ61_RS09095	COG0528	UMP kinase activity
EXZ61_RS09100	COG0233	cytoplasmic translational termination
EXZ61_RS09110	COG0575	Belongs to the CDS family
EXZ61_RS09115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
EXZ61_RS09120	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
EXZ61_RS09130	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXZ61_RS09135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
EXZ61_RS09140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXZ61_RS09145	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
EXZ61_RS09150	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
EXZ61_RS09155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXZ61_RS09160	COG0505	Belongs to the CarA family
EXZ61_RS09170	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
EXZ61_RS09175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
EXZ61_RS09185	COG1534	Rna-binding protein
EXZ61_RS09190	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
EXZ61_RS09195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXZ61_RS09205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
EXZ61_RS09220	COG0431	NADPH-dependent FMN reductase
EXZ61_RS09255	COG0438	transferase activity, transferring glycosyl groups
EXZ61_RS09280	COG0248	Ppx GppA phosphatase
EXZ61_RS09290	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
EXZ61_RS09295	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
EXZ61_RS09300	COG0573	inorganic phosphate transmembrane transporter activity
EXZ61_RS09305	COG0581	inorganic phosphate transmembrane transporter activity
EXZ61_RS09310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
EXZ61_RS09335	COG0492	ferredoxin-NADP+ reductase activity
EXZ61_RS09350	COG0175	sulfate reduction
EXZ61_RS09355	COG0175	sulfate reduction
EXZ61_RS09370	COG0730	response to heat
EXZ61_RS09385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXZ61_RS09390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXZ61_RS09395	COG2313	pseudouridylate synthase activity
EXZ61_RS09420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
EXZ61_RS09420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXZ61_RS09425	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
EXZ61_RS09430	COG3706	GGDEF domain
EXZ61_RS09430	COG2203	Gaf domain
EXZ61_RS09430	COG5001	Diguanylate cyclase
EXZ61_RS09430	COG4251	negative regulation of phosphorylation
EXZ61_RS09440	COG1619	proteins homologs of microcin C7 resistance protein MccF
EXZ61_RS09455	COG0436	Aminotransferase
EXZ61_RS09460	COG0583	DNA-binding transcription factor activity
EXZ61_RS09470	COG0795	lipopolysaccharide-transporting ATPase activity
EXZ61_RS09480	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
EXZ61_RS09505	COG2205	protein histidine kinase activity
EXZ61_RS09505	COG0784	Response regulator, receiver
EXZ61_RS09510	COG2205	protein histidine kinase activity
EXZ61_RS09510	COG5002	protein histidine kinase activity
EXZ61_RS09510	COG0784	Response regulator, receiver
EXZ61_RS09520	COG3706	GGDEF domain
EXZ61_RS09570	COG1982	Orn Lys Arg decarboxylase major
EXZ61_RS09580	COG4166	transmembrane transport
EXZ61_RS09585	COG4174	ABC transporter (Permease)
EXZ61_RS09590	COG4239	(ABC) transporter, permease
EXZ61_RS09595	COG4172	Belongs to the ABC transporter superfamily
EXZ61_RS09600	COG0779	Required for maturation of 30S ribosomal subunits
EXZ61_RS09605	COG2251	uridine kinase activity
EXZ61_RS09605	COG0195	Participates in both transcription termination and antitermination
EXZ61_RS09610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
EXZ61_RS09615	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
EXZ61_RS09620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
EXZ61_RS09635	COG1024	Enoyl-CoA hydratase
EXZ61_RS09640	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
EXZ61_RS09650	COG2914	Belongs to the UPF0125 (RnfH) family
EXZ61_RS09665	COG0519	Catalyzes the synthesis of GMP from XMP
EXZ61_RS09665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
EXZ61_RS09680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
EXZ61_RS09680	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
EXZ61_RS09685	COG1643	Atp-dependent helicase
EXZ61_RS09690	COG3437	response regulator, receiver
EXZ61_RS09720	COG0579	oxidoreductase
EXZ61_RS09725	COG0167	dihydroorotate dehydrogenase activity
EXZ61_RS09730	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
EXZ61_RS09745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
EXZ61_RS09750	COG4566	intracellular signal transduction
EXZ61_RS09755	COG4191	Histidine kinase
EXZ61_RS09760	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EXZ61_RS09765	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXZ61_RS09770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXZ61_RS09790	COG3621	Patatin-like phospholipase
EXZ61_RS09795	COG3501	Rhs element vgr protein
EXZ61_RS09805	COG1215	transferase activity, transferring glycosyl groups
EXZ61_RS09855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
EXZ61_RS09870	COG0527	aspartate kinase activity
EXZ61_RS09885	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
EXZ61_RS09905	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXZ61_RS09910	COG2133	pyrroloquinoline quinone binding
EXZ61_RS09925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXZ61_RS09930	COG0444	Belongs to the ABC transporter superfamily
EXZ61_RS09935	COG4608	Belongs to the ABC transporter superfamily
EXZ61_RS09940	COG0019	diaminopimelate decarboxylase activity
EXZ61_RS09950	COG0583	DNA-binding transcription factor activity
EXZ61_RS09985	COG1196	nuclear chromosome segregation
EXZ61_RS09990	COG1132	(ABC) transporter
EXZ61_RS09995	COG0824	Thioesterase
EXZ61_RS10000	COG1454	alcohol dehydrogenase
EXZ61_RS10010	COG2197	response regulator
EXZ61_RS10040	COG2201	protein-glutamate methylesterase activity
EXZ61_RS10045	COG5002	protein histidine kinase activity
EXZ61_RS10055	COG5002	protein histidine kinase activity
EXZ61_RS10065	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS10080	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
EXZ61_RS10085	COG3118	belongs to the thioredoxin family
EXZ61_RS10095	COG1199	ATP-dependent helicase activity
EXZ61_RS10110	COG0564	pseudouridine synthase activity
EXZ61_RS10115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
EXZ61_RS10125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXZ61_RS10130	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
EXZ61_RS10135	COG0583	DNA-binding transcription factor activity
EXZ61_RS10140	COG1741	Belongs to the pirin family
EXZ61_RS10145	COG2259	Doxx family
EXZ61_RS10160	COG1741	Belongs to the pirin family
EXZ61_RS10185	COG0204	Acyl-transferase
EXZ61_RS10225	COG0583	DNA-binding transcription factor activity
EXZ61_RS10245	COG2951	lytic endotransglycosylase activity
EXZ61_RS10260	COG0714	Associated with various cellular activities
EXZ61_RS10270	COG1511	domain protein
EXZ61_RS10270	COG3264	Mechanosensitive ion channel
EXZ61_RS10280	COG0668	transmembrane transport
EXZ61_RS10310	COG2258	MOSC domain
EXZ61_RS10315	COG1454	alcohol dehydrogenase
EXZ61_RS10330	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS10335	COG1129	ABC transporter
EXZ61_RS10340	COG1172	Belongs to the binding-protein-dependent transport system permease family
EXZ61_RS10350	COG0179	Fumarylacetoacetate (FAA) hydrolase
EXZ61_RS10355	COG4948	Mandelate Racemase Muconate Lactonizing
EXZ61_RS10360	COG3618	amidohydrolase
EXZ61_RS10365	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS10370	COG3254	rhamnose metabolic process
EXZ61_RS10390	COG0484	heat shock protein binding
EXZ61_RS10395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXZ61_RS10440	COG0297	glycogen (starch) synthase activity
EXZ61_RS10455	COG0463	Glycosyl transferase, family 2
EXZ61_RS10480	COG1091	dTDP-4-dehydrorhamnose reductase activity
EXZ61_RS10530	COG0800	Aldolase
EXZ61_RS10540	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
EXZ61_RS10545	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
EXZ61_RS10570	COG2890	protein-(glutamine-N5) methyltransferase activity
EXZ61_RS10575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
EXZ61_RS10585	COG2171	N-acyltransferase activity
EXZ61_RS10590	COG0436	Aminotransferase
EXZ61_RS10605	COG1196	nuclear chromosome segregation
EXZ61_RS10615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
EXZ61_RS10620	COG0242	peptide deformylase activity
EXZ61_RS10625	COG2986	histidine ammonia-lyase
EXZ61_RS10630	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
EXZ61_RS10635	COG1414	Transcriptional regulator
EXZ61_RS10640	COG2188	Transcriptional regulator
EXZ61_RS10650	COG1228	amidohydrolase
EXZ61_RS10690	COG1522	sequence-specific DNA binding
EXZ61_RS10700	COG2154	pterin-4-alpha-carbinolamine dehydratase
EXZ61_RS10705	COG3186	Phenylalanine-4-hydroxylase
EXZ61_RS10710	COG0028	Belongs to the TPP enzyme family
EXZ61_RS10715	COG0747	negative chemotaxis
EXZ61_RS10720	COG4608	Belongs to the ABC transporter superfamily
EXZ61_RS10725	COG0444	Belongs to the ABC transporter superfamily
EXZ61_RS10730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXZ61_RS10735	COG0601	transmembrane transport
EXZ61_RS10745	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
EXZ61_RS10760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXZ61_RS10770	COG0174	glutamine synthetase
EXZ61_RS10785	COG3842	ATPase activity
EXZ61_RS10790	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXZ61_RS10795	COG1177	transmembrane transport
EXZ61_RS10800	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS10805	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
EXZ61_RS10815	COG2224	Isocitrate lyase
EXZ61_RS10820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
EXZ61_RS10825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
EXZ61_RS10830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
EXZ61_RS10835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
EXZ61_RS10840	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
EXZ61_RS10845	COG0072	phenylalanine-tRNA ligase activity
EXZ61_RS10845	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
EXZ61_RS10850	COG0776	regulation of translation
EXZ61_RS10855	COG0789	Transcriptional regulator
EXZ61_RS10870	COG0084	hydrolase, TatD family'
EXZ61_RS10885	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
EXZ61_RS10890	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
EXZ61_RS10900	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
EXZ61_RS10910	COG0840	transmembrane signaling receptor activity
EXZ61_RS10925	COG2183	response to ionizing radiation
EXZ61_RS10940	COG0583	DNA-binding transcription factor activity
EXZ61_RS10965	COG3119	arylsulfatase activity
EXZ61_RS10970	COG0123	including yeast histone deacetylase and acetoin utilization protein
EXZ61_RS10985	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXZ61_RS11020	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS11030	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS11040	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS11050	COG0183	Belongs to the thiolase family
EXZ61_RS11055	COG1024	Enoyl-CoA hydratase
EXZ61_RS11055	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXZ61_RS11065	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
EXZ61_RS11070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXZ61_RS11075	COG2917	probably involved in intracellular septation
EXZ61_RS11085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXZ61_RS11135	COG3501	Rhs element vgr protein
EXZ61_RS11200	COG3501	Rhs element vgr protein
EXZ61_RS11250	COG0047	phosphoribosylformylglycinamidine synthase activity
EXZ61_RS11250	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
EXZ61_RS11255	COG0024	Methionine aminopeptidase
EXZ61_RS11265	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS11270	COG0183	Belongs to the thiolase family
EXZ61_RS11275	COG1250	3-hydroxyacyl-CoA dehydrogenase
EXZ61_RS11275	COG1024	Enoyl-CoA hydratase
EXZ61_RS11280	COG2267	carboxylic ester hydrolase activity
EXZ61_RS11305	COG2059	Chromate
EXZ61_RS11310	COG0697	spore germination
EXZ61_RS11330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
EXZ61_RS11335	COG4181	ATPase activity
EXZ61_RS11370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
EXZ61_RS11375	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
EXZ61_RS11380	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
EXZ61_RS11385	COG0330	HflC and HflK could
EXZ61_RS11390	COG0330	HflC and HflK could
EXZ61_RS11395	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
EXZ61_RS11400	COG1923	regulation of RNA biosynthetic process
EXZ61_RS11405	COG1160	GTP binding
EXZ61_RS11420	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
EXZ61_RS11435	COG0820	rRNA (adenine-C2-)-methyltransferase activity
EXZ61_RS11440	COG0105	UTP biosynthetic process
EXZ61_RS11445	COG1187	pseudouridine synthase activity
EXZ61_RS11450	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
EXZ61_RS11465	COG1199	ATP-dependent helicase activity
EXZ61_RS11485	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
EXZ61_RS11490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXZ61_RS11495	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXZ61_RS11500	COG0567	Dehydrogenase, E1 component
EXZ61_RS11515	COG0791	NLP P60 protein
EXZ61_RS11530	COG0513	Belongs to the DEAD box helicase family
EXZ61_RS11535	COG5002	protein histidine kinase activity
EXZ61_RS11545	COG0583	DNA-binding transcription factor activity
EXZ61_RS11550	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
EXZ61_RS11555	COG3842	ATPase activity
EXZ61_RS11560	COG1176	ABC-type spermidine putrescine transport system, permease component I
EXZ61_RS11565	COG1177	transmembrane transport
EXZ61_RS11570	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS11575	COG0840	transmembrane signaling receptor activity
EXZ61_RS11580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS11580	COG2205	protein histidine kinase activity
EXZ61_RS11585	COG5001	Diguanylate cyclase
EXZ61_RS11585	COG3300	MHYT domain
EXZ61_RS11600	COG1233	COG1233 Phytoene dehydrogenase and related
EXZ61_RS11620	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
EXZ61_RS11630	COG0601	transmembrane transport
EXZ61_RS11635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
EXZ61_RS11640	COG0444	Belongs to the ABC transporter superfamily
EXZ61_RS11645	COG4608	Belongs to the ABC transporter superfamily
EXZ61_RS11680	COG0504	CTP synthase activity
EXZ61_RS11690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXZ61_RS11695	COG1653	transport
EXZ61_RS11705	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS11725	COG1609	Transcriptional regulator
EXZ61_RS11730	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS11735	COG0583	DNA-binding transcription factor activity
EXZ61_RS11740	COG1396	sequence-specific DNA binding
EXZ61_RS11745	COG3550	peptidyl-serine autophosphorylation
EXZ61_RS11750	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS11765	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS11775	COG1846	Transcriptional regulator
EXZ61_RS11780	COG1538	Outer membrane efflux protein
EXZ61_RS11785	COG1566	PFAM secretion protein HlyD family protein
EXZ61_RS11795	COG0295	cytidine deaminase activity
EXZ61_RS11810	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
EXZ61_RS11820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
EXZ61_RS11855	COG1322	Protein conserved in bacteria
EXZ61_RS11870	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXZ61_RS11885	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXZ61_RS11890	COG0542	response to heat
EXZ61_RS11895	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
EXZ61_RS11915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS11945	COG3278	Belongs to the heme-copper respiratory oxidase family
EXZ61_RS11955	COG2217	Heavy metal translocating P-type atpase
EXZ61_RS11970	COG2205	protein histidine kinase activity
EXZ61_RS11970	COG0784	Response regulator, receiver
EXZ61_RS11970	COG5002	protein histidine kinase activity
EXZ61_RS11980	COG0318	PFAM AMP-dependent synthetase and ligase
EXZ61_RS11990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
EXZ61_RS11995	COG0583	DNA-binding transcription factor activity
EXZ61_RS12000	COG0129	dihydroxy-acid dehydratase activity
EXZ61_RS12010	COG4654	Cytochrome c, class I
EXZ61_RS12015	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
EXZ61_RS12030	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
EXZ61_RS12045	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
EXZ61_RS12050	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
EXZ61_RS12055	COG1414	Transcriptional regulator
EXZ61_RS12065	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
EXZ61_RS12070	COG1183	phosphatidylcholine synthase activity
EXZ61_RS12075	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
EXZ61_RS12080	COG0440	acetolactate synthase activity
EXZ61_RS12085	COG0028	Belongs to the TPP enzyme family
EXZ61_RS12110	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
EXZ61_RS12120	COG0347	Belongs to the P(II) protein family
EXZ61_RS12125	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXZ61_RS12125	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXZ61_RS12135	COG0840	transmembrane signaling receptor activity
EXZ61_RS12140	COG0840	transmembrane signaling receptor activity
EXZ61_RS12145	COG0835	chemotaxis
EXZ61_RS12150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXZ61_RS12150	COG2226	methyltransferase
EXZ61_RS12150	COG0596	Alpha beta hydrolase
EXZ61_RS12155	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
EXZ61_RS12170	COG2205	protein histidine kinase activity
EXZ61_RS12170	COG2198	Histidine kinase
EXZ61_RS12170	COG0784	Response regulator, receiver
EXZ61_RS12185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
EXZ61_RS12190	COG0746	molybdenum cofactor guanylyltransferase activity
EXZ61_RS12195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
EXZ61_RS12205	COG0328	RNA-DNA hybrid ribonuclease activity
EXZ61_RS12215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXZ61_RS12220	COG1388	LysM domain
EXZ61_RS12220	COG0741	lytic transglycosylase activity
EXZ61_RS12230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
EXZ61_RS12235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
EXZ61_RS12255	COG3239	Fatty acid desaturase
EXZ61_RS12275	COG1074	ATP-dependent DNA helicase activity
EXZ61_RS12290	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
EXZ61_RS12295	COG0254	rRNA binding
EXZ61_RS12320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
EXZ61_RS12340	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS12350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXZ61_RS12355	COG0509	glycine decarboxylation via glycine cleavage system
EXZ61_RS12360	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXZ61_RS12360	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
EXZ61_RS12365	COG1760	l-serine dehydratase
EXZ61_RS12375	COG0625	glutathione transferase activity
EXZ61_RS12415	COG0417	DNA replication proofreading
EXZ61_RS12425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
EXZ61_RS12445	COG3842	ATPase activity
EXZ61_RS12455	COG4143	(ABC) transporter
EXZ61_RS12495	COG1132	(ABC) transporter
EXZ61_RS12510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
EXZ61_RS12530	COG1007	ATP synthesis coupled electron transport
EXZ61_RS12545	COG0713	ATP synthesis coupled electron transport
EXZ61_RS12555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXZ61_RS12560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
EXZ61_RS12565	COG1034	ATP synthesis coupled electron transport
EXZ61_RS12580	COG0649	NAD binding
EXZ61_RS12585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXZ61_RS12590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXZ61_RS12595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
EXZ61_RS12610	COG0149	triose-phosphate isomerase activity
EXZ61_RS12615	COG3321	synthase
EXZ61_RS12615	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS12615	COG0604	alcohol dehydrogenase
EXZ61_RS12620	COG1185	polyribonucleotide nucleotidyltransferase activity
EXZ61_RS12625	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
EXZ61_RS12635	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
EXZ61_RS12640	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EXZ61_RS12650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXZ61_RS12655	COG0275	rRNA processing
EXZ61_RS12680	COG0346	lactoylglutathione lyase activity
EXZ61_RS12695	COG3842	ATPase activity
EXZ61_RS12700	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXZ61_RS12710	COG2081	HI0933 family
EXZ61_RS12715	COG0828	Belongs to the bacterial ribosomal protein bS21 family
EXZ61_RS12720	COG1610	YqeY-like protein
EXZ61_RS12725	COG0312	modulator of DNA gyrase
EXZ61_RS12730	COG3028	Belongs to the UPF0307 family
EXZ61_RS12735	COG0521	Mo-molybdopterin cofactor biosynthetic process
EXZ61_RS12740	COG1045	serine acetyltransferase
EXZ61_RS12770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
EXZ61_RS12795	COG0778	Nitroreductase
EXZ61_RS12810	COG4974	Belongs to the 'phage' integrase family
EXZ61_RS12845	COG0789	Transcriptional regulator
EXZ61_RS12895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXZ61_RS12995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
EXZ61_RS13010	COG5002	protein histidine kinase activity
EXZ61_RS13020	COG1968	undecaprenyl-diphosphatase activity
EXZ61_RS13025	COG0577	efflux transmembrane transporter activity
EXZ61_RS13025	COG1136	(ABC) transporter
EXZ61_RS13030	COG1136	(ABC) transporter
EXZ61_RS13050	COG3275	phosphorelay sensor kinase activity
EXZ61_RS13075	COG0577	efflux transmembrane transporter activity
EXZ61_RS13080	COG1136	(ABC) transporter
EXZ61_RS13100	COG3706	GGDEF domain
EXZ61_RS13105	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
EXZ61_RS13160	COG0572	uridine kinase
EXZ61_RS13170	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS13210	COG2249	NAD(P)H dehydrogenase (quinone) activity
EXZ61_RS13250	COG3228	Belongs to the MtfA family
EXZ61_RS13290	COG2267	carboxylic ester hydrolase activity
EXZ61_RS13295	COG0363	glucosamine-6-phosphate deaminase activity
EXZ61_RS13300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
EXZ61_RS13305	COG0583	DNA-binding transcription factor activity
EXZ61_RS13310	COG5002	protein histidine kinase activity
EXZ61_RS13310	COG2205	protein histidine kinase activity
EXZ61_RS13310	COG0784	Response regulator, receiver
EXZ61_RS13325	COG4191	Histidine kinase
EXZ61_RS13345	COG2766	serine protein kinase
EXZ61_RS13350	COG2718	Belongs to the UPF0229 family
EXZ61_RS13355	COG2719	SpoVR family
EXZ61_RS13375	COG2918	glutathione biosynthetic process
EXZ61_RS13385	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
EXZ61_RS13400	COG3634	alkyl hydroperoxide reductase activity
EXZ61_RS13420	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXZ61_RS13425	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
EXZ61_RS13430	COG0084	hydrolase, TatD family'
EXZ61_RS13440	COG0259	pyridoxamine-phosphate oxidase activity
EXZ61_RS13455	COG0840	transmembrane signaling receptor activity
EXZ61_RS13470	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
EXZ61_RS13475	COG2188	Transcriptional regulator
EXZ61_RS13480	COG0444	Belongs to the ABC transporter superfamily
EXZ61_RS13485	COG4608	Belongs to the ABC transporter superfamily
EXZ61_RS13520	COG1940	carbohydrate kinase activity
EXZ61_RS13530	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EXZ61_RS13535	COG1136	(ABC) transporter
EXZ61_RS13550	COG0456	acetyltransferase
EXZ61_RS13575	COG1335	isochorismatase
EXZ61_RS13595	COG0667	Aldo Keto reductase
EXZ61_RS13605	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS13615	COG0183	Belongs to the thiolase family
EXZ61_RS13640	COG2130	NADP-dependent
EXZ61_RS13645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS13650	COG4597	amino acid ABC transporter
EXZ61_RS13655	COG0765	amino acid transport
EXZ61_RS13660	COG1126	abc transporter atp-binding protein
EXZ61_RS13670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
EXZ61_RS13675	COG0840	transmembrane signaling receptor activity
EXZ61_RS13680	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS13685	COG5002	protein histidine kinase activity
EXZ61_RS13685	COG2205	protein histidine kinase activity
EXZ61_RS13685	COG0784	Response regulator, receiver
EXZ61_RS13700	COG0488	(ABC) transporter
EXZ61_RS13710	COG0513	Belongs to the DEAD box helicase family
EXZ61_RS13755	COG1881	PFAM PEBP family protein
EXZ61_RS13795	COG1121	(ABC) transporter
EXZ61_RS13805	COG0803	Belongs to the bacterial solute-binding protein 9 family
EXZ61_RS13840	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
EXZ61_RS13890	COG0583	DNA-binding transcription factor activity
EXZ61_RS13895	COG0586	Pfam SNARE associated Golgi protein
EXZ61_RS13900	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
EXZ61_RS13920	COG1294	oxidase, subunit
EXZ61_RS13925	COG1271	oxidase subunit
EXZ61_RS13940	COG3842	ATPase activity
EXZ61_RS13945	COG1940	carbohydrate kinase activity
EXZ61_RS13950	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS13955	COG1175	transmembrane transport
EXZ61_RS13960	COG1653	transport
EXZ61_RS13975	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
EXZ61_RS13980	COG1136	(ABC) transporter
EXZ61_RS13985	COG2205	protein histidine kinase activity
EXZ61_RS13985	COG0784	Response regulator, receiver
EXZ61_RS13985	COG5002	protein histidine kinase activity
EXZ61_RS13990	COG3437	response regulator, receiver
EXZ61_RS14010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
EXZ61_RS14020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
EXZ61_RS14035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXZ61_RS14045	COG1295	ribonuclease BN
EXZ61_RS14055	COG0277	FAD linked oxidase domain protein
EXZ61_RS14070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
EXZ61_RS14085	COG0708	Exodeoxyribonuclease III
EXZ61_RS14100	COG3852	Histidine kinase
EXZ61_RS14110	COG0174	glutamine synthetase
EXZ61_RS14140	COG1187	pseudouridine synthase activity
EXZ61_RS14145	COG3437	response regulator, receiver
EXZ61_RS14145	COG0784	Response regulator, receiver
EXZ61_RS14160	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
EXZ61_RS14170	COG1086	Polysaccharide biosynthesis protein
EXZ61_RS14190	COG0438	transferase activity, transferring glycosyl groups
EXZ61_RS14195	COG0463	Glycosyl transferase, family 2
EXZ61_RS14220	COG0463	Glycosyl transferase, family 2
EXZ61_RS14235	COG1696	Membrane protein involved in D-alanine export
EXZ61_RS14240	COG0702	epimerase
EXZ61_RS14280	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
EXZ61_RS14305	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXZ61_RS14320	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
EXZ61_RS14330	COG0287	Prephenate dehydrogenase
EXZ61_RS14335	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
EXZ61_RS14345	COG0776	regulation of translation
EXZ61_RS14355	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
EXZ61_RS14360	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
EXZ61_RS14365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
EXZ61_RS14375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
EXZ61_RS14380	COG0840	transmembrane signaling receptor activity
EXZ61_RS14385	COG0589	response to stress
EXZ61_RS14405	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
EXZ61_RS14410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
EXZ61_RS14415	COG0142	geranyltranstransferase activity
EXZ61_RS14420	COG1722	exodeoxyribonuclease VII activity
EXZ61_RS14450	COG0583	DNA-binding transcription factor activity
EXZ61_RS14455	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS14460	COG3706	GGDEF domain
EXZ61_RS14465	COG2267	carboxylic ester hydrolase activity
EXZ61_RS14470	COG0840	transmembrane signaling receptor activity
EXZ61_RS14515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS14515	COG2205	protein histidine kinase activity
EXZ61_RS14525	COG0840	transmembrane signaling receptor activity
EXZ61_RS14535	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
EXZ61_RS14560	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS14565	COG2205	protein histidine kinase activity
EXZ61_RS14605	COG1196	nuclear chromosome segregation
EXZ61_RS14685	COG3267	Type II secretory pathway component ExeA
EXZ61_RS14685	COG3409	Peptidoglycan-binding domain 1 protein
EXZ61_RS14835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
EXZ61_RS14860	COG1090	epimerase
EXZ61_RS14900	COG2831	hemolysin activation secretion protein
EXZ61_RS14915	COG3210	domain, Protein
EXZ61_RS14940	COG0210	DNA helicase
EXZ61_RS14945	COG0516	GMP reductase activity
EXZ61_RS14950	COG2084	Dehydrogenase
EXZ61_RS14955	COG0513	Belongs to the DEAD box helicase family
EXZ61_RS14960	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
EXZ61_RS14965	COG0501	Belongs to the peptidase M48B family
EXZ61_RS14975	COG1162	GTPase activity
EXZ61_RS14990	COG0335	large ribosomal subunit rRNA binding
EXZ61_RS14995	COG0336	Belongs to the RNA methyltransferase TrmD family
EXZ61_RS15000	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
EXZ61_RS15005	COG0228	four-way junction DNA binding
EXZ61_RS15035	COG4948	Mandelate Racemase Muconate Lactonizing
EXZ61_RS15050	COG4566	intracellular signal transduction
EXZ61_RS15070	COG0039	L-malate dehydrogenase activity
EXZ61_RS15075	COG2188	Transcriptional regulator
EXZ61_RS15085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
EXZ61_RS15090	COG1053	succinate dehydrogenase
EXZ61_RS15095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
EXZ61_RS15100	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
EXZ61_RS15105	COG0372	Belongs to the citrate synthase family
EXZ61_RS15110	COG0583	DNA-binding transcription factor activity
EXZ61_RS15115	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
EXZ61_RS15125	COG0066	3-isopropylmalate dehydratase activity
EXZ61_RS15130	COG0473	3-isopropylmalate dehydrogenase activity
EXZ61_RS15135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
EXZ61_RS15145	COG0101	tRNA pseudouridine synthase activity
EXZ61_RS15150	COG0135	phosphoribosylanthranilate isomerase activity
EXZ61_RS15155	COG0133	tryptophan synthase activity
EXZ61_RS15160	COG0159	tryptophan synthase activity
EXZ61_RS15165	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
EXZ61_RS15170	COG0762	integral membrane protein
EXZ61_RS15175	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
EXZ61_RS15180	COG1451	nucleotide metabolic process
EXZ61_RS15185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS15190	COG3530	Putative quorum-sensing-regulated virulence factor
EXZ61_RS15195	COG0023	Translation Initiation Factor
EXZ61_RS15205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
EXZ61_RS15220	COG1472	Belongs to the glycosyl hydrolase 3 family
EXZ61_RS15225	COG0736	holo-[acyl-carrier-protein] synthase activity
EXZ61_RS15230	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
EXZ61_RS15235	COG1381	Involved in DNA repair and RecF pathway recombination
EXZ61_RS15240	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
EXZ61_RS15245	COG0571	ribonuclease III activity
EXZ61_RS15255	COG0681	Belongs to the peptidase S26 family
EXZ61_RS15260	COG0481	GTPase activity
EXZ61_RS15265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
EXZ61_RS15285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
EXZ61_RS15290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXZ61_RS15305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
EXZ61_RS15310	COG0416	fatty acid biosynthetic process
EXZ61_RS15315	COG0333	Belongs to the bacterial ribosomal protein bL32 family
EXZ61_RS15320	COG1399	metal-binding, possibly nucleic acid-binding protein
EXZ61_RS15325	COG0424	maF-like protein
EXZ61_RS15330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
EXZ61_RS15335	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
EXZ61_RS15335	COG0616	signal peptide processing
EXZ61_RS15345	COG0546	phosphoglycolate phosphatase activity
EXZ61_RS15355	COG1530	ribonuclease E activity
EXZ61_RS15360	COG3706	GGDEF domain
EXZ61_RS15380	COG0181	hydroxymethylbilane synthase activity
EXZ61_RS15385	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
EXZ61_RS15395	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS15395	COG2972	Histidine kinase
EXZ61_RS15400	COG0165	Argininosuccinate lyase
EXZ61_RS15405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS15405	COG4191	Histidine kinase
EXZ61_RS15410	COG4191	Histidine kinase
EXZ61_RS15410	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS15420	COG0477	Major facilitator Superfamily
EXZ61_RS15455	COG3474	cytochrome
EXZ61_RS15475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS15520	COG0861	Integral membrane protein TerC family
EXZ61_RS15525	COG0583	DNA-binding transcription factor activity
EXZ61_RS15550	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS15585	COG1304	FMN binding
EXZ61_RS15590	COG0045	succinate-CoA ligase (ADP-forming) activity
EXZ61_RS15590	COG1042	CoA-binding domain protein
EXZ61_RS15590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXZ61_RS15600	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
EXZ61_RS15630	COG0840	transmembrane signaling receptor activity
EXZ61_RS15645	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXZ61_RS15645	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
EXZ61_RS15655	COG3022	response to hydroperoxide
EXZ61_RS15660	COG1278	Cold shock
EXZ61_RS15665	COG0525	valine-tRNA ligase activity
EXZ61_RS15670	COG0425	Belongs to the sulfur carrier protein TusA family
EXZ61_RS15675	COG2816	NAD+ diphosphatase activity
EXZ61_RS15800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
EXZ61_RS15805	COG1522	sequence-specific DNA binding
EXZ61_RS15815	COG0583	DNA-binding transcription factor activity
EXZ61_RS15820	COG0626	cystathionine gamma-synthase activity
EXZ61_RS15835	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS15840	COG3842	ATPase activity
EXZ61_RS15850	COG2909	trisaccharide binding
EXZ61_RS15930	COG1522	sequence-specific DNA binding
EXZ61_RS15935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXZ61_RS15945	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
EXZ61_RS15950	COG1942	4-Oxalocrotonate Tautomerase
EXZ61_RS15955	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
EXZ61_RS15960	COG1674	ftsk spoiiie
EXZ61_RS15970	COG0492	ferredoxin-NADP+ reductase activity
EXZ61_RS15975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
EXZ61_RS15980	COG0267	Belongs to the bacterial ribosomal protein bL33 family
EXZ61_RS15990	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXZ61_RS15990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXZ61_RS16000	COG2205	protein histidine kinase activity
EXZ61_RS16015	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
EXZ61_RS16020	COG3132	Protein of unknown function, DUF480
EXZ61_RS16025	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS16030	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS16040	COG1793	dna ligase
EXZ61_RS16045	COG1309	transcriptional regulator
EXZ61_RS16055	COG1803	Methylglyoxal synthase
EXZ61_RS16065	COG0196	riboflavin kinase activity
EXZ61_RS16070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
EXZ61_RS16075	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
EXZ61_RS16090	COG0840	transmembrane signaling receptor activity
EXZ61_RS16100	COG0697	spore germination
EXZ61_RS16105	COG2223	nitrite transmembrane transporter activity
EXZ61_RS16110	COG4977	sequence-specific DNA binding
EXZ61_RS16120	COG1940	carbohydrate kinase activity
EXZ61_RS16125	COG3142	Participates in the control of copper homeostasis
EXZ61_RS16130	COG0697	spore germination
EXZ61_RS16135	COG2354	Protein conserved in bacteria
EXZ61_RS16150	COG0427	acetyl-CoA hydrolase
EXZ61_RS16180	COG0596	Alpha beta hydrolase
EXZ61_RS16180	COG0508	dehydrogenase complex catalyzes the overall conversion of
EXZ61_RS16220	COG0737	Belongs to the 5'-nucleotidase family
EXZ61_RS16235	COG0613	PHP domain protein
EXZ61_RS16240	COG0009	L-threonylcarbamoyladenylate synthase
EXZ61_RS16245	COG1994	Peptidase M50
EXZ61_RS16250	COG0180	Tryptophanyl-tRNA synthetase
EXZ61_RS16260	COG0442	prolyl-tRNA aminoacylation
EXZ61_RS16265	COG0494	nUDIX hydrolase
EXZ61_RS16275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
EXZ61_RS16280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
EXZ61_RS16285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
EXZ61_RS16290	COG0261	This protein binds to 23S rRNA in the presence of protein L20
EXZ61_RS16295	COG0142	geranyltranstransferase activity
EXZ61_RS16315	COG0237	dephospho-CoA kinase activity
EXZ61_RS16330	COG0494	nUDIX hydrolase
EXZ61_RS16340	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
EXZ61_RS16345	COG0653	protein targeting
EXZ61_RS16350	COG0739	heme binding
EXZ61_RS16365	COG2969	positive regulation of protein catabolic process
EXZ61_RS16370	COG0625	glutathione transferase activity
EXZ61_RS16375	COG2857	Cytochrome c1
EXZ61_RS16380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
EXZ61_RS16385	COG0723	plastoquinol--plastocyanin reductase activity
EXZ61_RS16390	COG1970	mechanosensitive ion channel activity
EXZ61_RS16395	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EXZ61_RS16400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
EXZ61_RS16415	COG0805	protein transport
EXZ61_RS16420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXZ61_RS16425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
EXZ61_RS16435	COG0140	phosphoribosyl-ATP diphosphatase activity
EXZ61_RS16440	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
EXZ61_RS16445	COG0107	imidazoleglycerol-phosphate synthase activity
EXZ61_RS16450	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
EXZ61_RS16455	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
EXZ61_RS16460	COG0131	Imidazoleglycerol-phosphate dehydratase
EXZ61_RS16465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
EXZ61_RS16500	COG0583	DNA-binding transcription factor activity
EXZ61_RS16525	COG3540	Alkaline phosphatase
EXZ61_RS16530	COG0515	serine threonine protein kinase
EXZ61_RS16530	COG2815	serine threonine protein kinase
EXZ61_RS16565	COG0346	lactoylglutathione lyase activity
EXZ61_RS16570	COG0456	acetyltransferase
EXZ61_RS16590	COG2814	Major facilitator Superfamily
EXZ61_RS16605	COG0673	inositol 2-dehydrogenase activity
EXZ61_RS16615	COG0791	NLP P60 protein
EXZ61_RS16620	COG2951	lytic endotransglycosylase activity
EXZ61_RS16625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
EXZ61_RS16635	COG1999	signal sequence binding
EXZ61_RS16640	COG0109	protoheme IX farnesyltransferase activity
EXZ61_RS16675	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
EXZ61_RS16690	COG2226	methyltransferase
EXZ61_RS16695	COG1040	competence protein
EXZ61_RS16700	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
EXZ61_RS16705	COG0489	protein tyrosine kinase activity
EXZ61_RS16725	COG0183	Belongs to the thiolase family
EXZ61_RS16750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
EXZ61_RS16790	COG0540	Belongs to the ATCase OTCase family
EXZ61_RS16795	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
EXZ61_RS16800	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
EXZ61_RS16805	COG1678	Uncharacterized ACR, COG1678
EXZ61_RS16810	COG0415	Belongs to the DNA photolyase family
EXZ61_RS16815	COG0643	Histidine kinase
EXZ61_RS16815	COG0784	Response regulator, receiver
EXZ61_RS16815	COG2198	Histidine kinase
EXZ61_RS16820	COG0840	transmembrane signaling receptor activity
EXZ61_RS16840	COG1773	rubredoxin
EXZ61_RS16850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
EXZ61_RS16855	COG0612	Peptidase, M16
EXZ61_RS16860	COG0612	Peptidase, M16
EXZ61_RS16870	COG4134	Bacterial extracellular solute-binding protein
EXZ61_RS16880	COG0400	carboxylic ester hydrolase activity
EXZ61_RS16885	COG0443	Heat shock 70 kDa protein
EXZ61_RS16890	COG4135	transport system, permease component
EXZ61_RS16900	COG4136	ATPase activity
EXZ61_RS16910	COG3706	GGDEF domain
EXZ61_RS16915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXZ61_RS16925	COG1773	rubredoxin
EXZ61_RS16935	COG1309	transcriptional regulator
EXZ61_RS16950	COG0697	spore germination
EXZ61_RS16960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
EXZ61_RS16965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
EXZ61_RS16975	COG0709	Synthesizes selenophosphate from selenide and ATP
EXZ61_RS16980	COG1252	NADH dehydrogenase
EXZ61_RS17000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXZ61_RS17010	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
EXZ61_RS17015	COG4178	(ABC) transporter
EXZ61_RS17040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXZ61_RS17050	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
EXZ61_RS17075	COG1473	amidohydrolase
EXZ61_RS17085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
EXZ61_RS17090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
EXZ61_RS17095	COG0166	Belongs to the GPI family
EXZ61_RS17100	COG3214	Protein conserved in bacteria
EXZ61_RS17110	COG0519	Catalyzes the synthesis of GMP from XMP
EXZ61_RS17120	COG0459	protein refolding
EXZ61_RS17125	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
EXZ61_RS17140	COG3437	response regulator, receiver
EXZ61_RS17170	COG3188	usher protein
EXZ61_RS17175	COG3121	Chaperone
EXZ61_RS17225	COG2771	luxR family
EXZ61_RS17265	COG1070	Carbohydrate kinase
EXZ61_RS17270	COG0322	excinuclease ABC activity
EXZ61_RS17285	COG1056	cytidyltransferase-related domain
EXZ61_RS17285	COG1051	belongs to the nudix hydrolase family
EXZ61_RS17290	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
EXZ61_RS17290	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
EXZ61_RS17305	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
EXZ61_RS17320	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
EXZ61_RS17355	COG1965	Belongs to the frataxin family
EXZ61_RS17365	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
EXZ61_RS17370	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
EXZ61_RS17375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
EXZ61_RS17380	COG1333	cytochrome c biogenesis protein
EXZ61_RS17390	COG0218	Necessary for normal cell division and for the maintenance of normal septation
EXZ61_RS17405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXZ61_RS17410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXZ61_RS17415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
EXZ61_RS17435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
EXZ61_RS17460	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
EXZ61_RS17470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
EXZ61_RS17515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS17520	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS17525	COG0583	DNA-binding transcription factor activity
EXZ61_RS17535	COG0784	Response regulator, receiver
EXZ61_RS17535	COG2198	Histidine kinase
EXZ61_RS17535	COG2205	protein histidine kinase activity
EXZ61_RS17540	COG0387	Pfam Sodium calcium exchanger
EXZ61_RS17555	COG1175	transmembrane transport
EXZ61_RS17575	COG0246	Mannitol dehydrogenase
EXZ61_RS17585	COG1070	Carbohydrate kinase
EXZ61_RS17590	COG0784	Response regulator, receiver
EXZ61_RS17590	COG2205	protein histidine kinase activity
EXZ61_RS17600	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS17620	COG3217	Mosc domain protein beta barrel domain protein
EXZ61_RS17620	COG0633	Ferredoxin
EXZ61_RS17620	COG0633	Ferredoxin
EXZ61_RS17620	COG3217	Mosc domain protein beta barrel domain protein
EXZ61_RS17630	COG0587	DNA-directed DNA polymerase activity
EXZ61_RS17635	COG0583	DNA-binding transcription factor activity
EXZ61_RS17640	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
EXZ61_RS17645	COG3002	Belongs to the UPF0753 family
EXZ61_RS17650	COG0737	Belongs to the 5'-nucleotidase family
EXZ61_RS17665	COG3707	response regulator
EXZ61_RS17670	COG0840	transmembrane signaling receptor activity
EXZ61_RS17675	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
EXZ61_RS17680	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
EXZ61_RS17685	COG1116	anion transmembrane transporter activity
EXZ61_RS17690	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
EXZ61_RS17700	COG0243	molybdopterin cofactor binding
EXZ61_RS17705	COG3945	hemerythrin HHE cation binding domain
EXZ61_RS17720	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXZ61_RS17720	COG0404	The glycine cleavage system catalyzes the degradation of glycine
EXZ61_RS17730	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
EXZ61_RS17745	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXZ61_RS17745	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS17750	COG2181	nitrate reductase activity
EXZ61_RS17750	COG0247	lactate metabolic process
EXZ61_RS17755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
EXZ61_RS17765	COG4638	Rieske (2fe-2S)
EXZ61_RS17770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EXZ61_RS17780	COG4175	Glycine betaine
EXZ61_RS17785	COG4176	ABC-type proline glycine betaine transport system permease component
EXZ61_RS17805	COG1012	belongs to the aldehyde dehydrogenase family
EXZ61_RS17810	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
EXZ61_RS17830	COG3437	response regulator, receiver
EXZ61_RS17830	COG2205	protein histidine kinase activity
EXZ61_RS17830	COG4999	Histidine kinase
EXZ61_RS17830	COG3850	Histidine kinase
EXZ61_RS17840	COG0583	DNA-binding transcription factor activity
EXZ61_RS17865	COG4251	negative regulation of phosphorylation
EXZ61_RS17870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXZ61_RS17885	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
EXZ61_RS17890	COG0741	lytic transglycosylase activity
EXZ61_RS17890	COG1196	nuclear chromosome segregation
EXZ61_RS17890	COG0739	heme binding
EXZ61_RS17900	COG0617	tRNA 3'-terminal CCA addition
EXZ61_RS17905	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS18015	COG2842	Transposition protein
EXZ61_RS18035	COG4396	Host-nuclease inhibitor protein Gam
EXZ61_RS18095	COG4386	tail sheath protein
EXZ61_RS18130	COG4381	Mu-like prophage protein gp46
EXZ61_RS18175	COG3842	ATPase activity
EXZ61_RS18180	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS18185	COG1175	transmembrane transport
EXZ61_RS18205	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
EXZ61_RS18205	COG0662	Cupin 2, conserved barrel domain protein
EXZ61_RS18215	COG4221	oxidoreductase activity
EXZ61_RS18225	COG0037	tRNA processing
EXZ61_RS18235	COG0406	alpha-ribazole phosphatase activity
EXZ61_RS18250	COG2119	membrane
EXZ61_RS18255	COG2255	four-way junction helicase activity
EXZ61_RS18260	COG3338	carbonate dehydratase activity
EXZ61_RS18270	COG0632	four-way junction helicase activity
EXZ61_RS18275	COG1702	phosphate starvation-inducible protein PhoH
EXZ61_RS18280	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
EXZ61_RS18300	COG1490	D-aminoacyl-tRNA deacylase activity
EXZ61_RS18310	COG4566	intracellular signal transduction
EXZ61_RS18320	COG0666	response to abiotic stimulus
EXZ61_RS18325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
EXZ61_RS18330	COG0739	heme binding
EXZ61_RS18335	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
EXZ61_RS18340	COG0316	Belongs to the HesB IscA family
EXZ61_RS18355	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
EXZ61_RS18360	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
EXZ61_RS18365	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
EXZ61_RS18375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
EXZ61_RS18380	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
EXZ61_RS18390	COG0366	Alpha amylase catalytic
EXZ61_RS18395	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS18400	COG1175	transmembrane transport
EXZ61_RS18405	COG1653	transport
EXZ61_RS18410	COG3842	ATPase activity
EXZ61_RS18415	COG0784	Response regulator, receiver
EXZ61_RS18415	COG3437	response regulator, receiver
EXZ61_RS18420	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
EXZ61_RS18445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
EXZ61_RS18460	COG0642	Histidine kinase
EXZ61_RS18465	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS18520	COG1122	ATPase activity
EXZ61_RS18530	COG1268	BioY protein
EXZ61_RS18535	COG0318	PFAM AMP-dependent synthetase and ligase
EXZ61_RS18550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
EXZ61_RS18570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
EXZ61_RS18585	COG3012	SEC-C Motif Domain Protein
EXZ61_RS18595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXZ61_RS18600	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS18615	COG0183	Belongs to the thiolase family
EXZ61_RS18625	COG2814	Major facilitator Superfamily
EXZ61_RS18630	COG0352	thiamine-phosphate diphosphorylase activity
EXZ61_RS18635	COG2022	thiamine diphosphate biosynthetic process
EXZ61_RS18650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
EXZ61_RS18655	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
EXZ61_RS18660	COG0288	reversible hydration of carbon dioxide
EXZ61_RS18670	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS18675	COG0789	Transcriptional regulator
EXZ61_RS18685	COG1752	Esterase of the alpha-beta hydrolase superfamily
EXZ61_RS18705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
EXZ61_RS18710	COG0751	glycine-tRNA ligase activity
EXZ61_RS18715	COG0752	glycyl-tRNA synthetase alpha subunit
EXZ61_RS18720	COG0815	Transfers the fatty acyl group on membrane lipoproteins
EXZ61_RS18840	COG2201	protein-glutamate methylesterase activity
EXZ61_RS18845	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
EXZ61_RS18850	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
EXZ61_RS18855	COG0835	chemotaxis
EXZ61_RS18860	COG0643	Histidine kinase
EXZ61_RS18860	COG2198	Histidine kinase
EXZ61_RS18865	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS18875	COG3851	Histidine kinase
EXZ61_RS18880	COG2197	response regulator
EXZ61_RS18895	COG1338	Plays a role in the flagellum-specific transport system
EXZ61_RS18905	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
EXZ61_RS18930	COG1157	protein secretion by the type III secretion system
EXZ61_RS18950	COG1677	Flagellar hook-basal body complex protein FliE
EXZ61_RS18990	COG1088	dTDP-glucose 4,6-dehydratase activity
EXZ61_RS19055	COG1538	Outer membrane efflux protein
EXZ61_RS19075	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
EXZ61_RS19100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
EXZ61_RS19110	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS19120	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
EXZ61_RS19135	COG1191	sigma factor activity
EXZ61_RS19165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
EXZ61_RS19170	COG1749	Flagellar hook protein flgE
EXZ61_RS19190	COG1706	bacterial-type flagellum-dependent cell motility
EXZ61_RS19205	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
EXZ61_RS19210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
EXZ61_RS19235	COG4251	negative regulation of phosphorylation
EXZ61_RS19255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS19260	COG0625	glutathione transferase activity
EXZ61_RS19265	COG0384	phenazine biosynthesis protein PhzF
EXZ61_RS19275	COG4191	Histidine kinase
EXZ61_RS19285	COG0004	ammonium transporteR
EXZ61_RS19300	COG0789	Transcriptional regulator
EXZ61_RS19305	COG1262	PFAM Formylglycine-generating sulfatase enzyme
EXZ61_RS19315	COG0784	Response regulator, receiver
EXZ61_RS19315	COG2205	protein histidine kinase activity
EXZ61_RS19325	COG1872	DUF167
EXZ61_RS19350	COG0513	Belongs to the DEAD box helicase family
EXZ61_RS19420	COG1024	Enoyl-CoA hydratase
EXZ61_RS19425	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS19465	COG0251	oxidation-reduction process
EXZ61_RS19470	COG1960	acyl-CoA dehydrogenase activity
EXZ61_RS19485	COG0697	spore germination
EXZ61_RS19490	COG0494	nUDIX hydrolase
EXZ61_RS19540	COG3501	Rhs element vgr protein
EXZ61_RS19555	COG3386	PFAM SMP-30 Gluconolaconase
EXZ61_RS19570	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS19575	COG1175	transmembrane transport
EXZ61_RS19580	COG1653	transport
EXZ61_RS19590	COG3842	ATPase activity
EXZ61_RS19595	COG0129	dihydroxy-acid dehydratase activity
EXZ61_RS19600	COG2186	Transcriptional regulator
EXZ61_RS19605	COG3734	2-keto-3-deoxy-galactonokinase
EXZ61_RS19610	COG0800	Aldolase
EXZ61_RS19620	COG0792	nuclease activity
EXZ61_RS19625	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
EXZ61_RS19635	COG2084	Dehydrogenase
EXZ61_RS19685	COG3181	Tripartite tricarboxylate transporter family receptor
EXZ61_RS19690	COG1703	isobutyryl-CoA mutase activity
EXZ61_RS19690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXZ61_RS19690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
EXZ61_RS19695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXZ61_RS19700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
EXZ61_RS19705	COG1473	amidohydrolase
EXZ61_RS19730	COG2831	hemolysin activation secretion protein
EXZ61_RS19735	COG0243	molybdopterin cofactor binding
EXZ61_RS19740	COG2910	NAD(P)H-binding
EXZ61_RS19750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
EXZ61_RS19755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
EXZ61_RS19760	COG3706	GGDEF domain
EXZ61_RS19770	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
EXZ61_RS19775	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
EXZ61_RS19785	COG0583	DNA-binding transcription factor activity
EXZ61_RS19815	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS19820	COG0405	Gamma-glutamyltransferase
EXZ61_RS19825	COG0679	Auxin Efflux Carrier
EXZ61_RS19830	COG0210	DNA helicase
EXZ61_RS19880	COG2204	response regulator
EXZ61_RS19885	COG5000	phosphorelay sensor kinase activity
EXZ61_RS19895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
EXZ61_RS19895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
EXZ61_RS19905	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
EXZ61_RS19910	COG0085	RNA polymerase activity
EXZ61_RS19915	COG0222	ribosome binding
EXZ61_RS19920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
EXZ61_RS19925	COG0081	regulation of translation
EXZ61_RS19930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
EXZ61_RS19950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXZ61_RS19975	COG0134	indole-3-glycerol-phosphate synthase activity
EXZ61_RS19980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
EXZ61_RS19985	COG1280	lysine exporter protein (LysE YggA)
EXZ61_RS19990	COG0512	Glutamine amidotransferase of anthranilate synthase
EXZ61_RS20010	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
EXZ61_RS20015	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
EXZ61_RS20040	COG0601	transmembrane transport
EXZ61_RS20055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
EXZ61_RS20060	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EXZ61_RS20065	COG0583	DNA-binding transcription factor activity
EXZ61_RS20070	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
EXZ61_RS20080	COG0489	protein tyrosine kinase activity
EXZ61_RS20085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
EXZ61_RS20090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
EXZ61_RS20095	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
EXZ61_RS20105	COG1385	rRNA (uridine-N3-)-methyltransferase activity
EXZ61_RS20125	COG0280	phosphate acetyltransferase
EXZ61_RS20125	COG0281	malic enzyme
EXZ61_RS20145	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
EXZ61_RS20195	COG0429	hydrolase of the alpha beta-hydrolase fold
EXZ61_RS20205	COG0355	proton-transporting ATP synthase activity, rotational mechanism
EXZ61_RS20210	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
EXZ61_RS20215	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
EXZ61_RS20220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
EXZ61_RS20225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
EXZ61_RS20230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
EXZ61_RS20240	COG0356	it plays a direct role in the translocation of protons across the membrane
EXZ61_RS20250	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
EXZ61_RS20260	COG3842	ATPase activity
EXZ61_RS20265	COG3842	ATPase activity
EXZ61_RS20270	COG1175	transmembrane transport
EXZ61_RS20275	COG0395	ABC-type sugar transport system, permease component
EXZ61_RS20290	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
EXZ61_RS20300	COG2921	Belongs to the UPF0250 family
EXZ61_RS20305	COG0321	lipoyl(octanoyl) transferase activity
EXZ61_RS20310	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
EXZ61_RS20315	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
EXZ61_RS20345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXZ61_RS20350	COG0583	DNA-binding transcription factor activity
EXZ61_RS20355	COG2814	Major facilitator Superfamily
EXZ61_RS20360	COG4533	DNA binding
EXZ61_RS20385	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
EXZ61_RS20390	COG5002	protein histidine kinase activity
EXZ61_RS20390	COG5001	Diguanylate cyclase
EXZ61_RS20400	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
EXZ61_RS20405	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
EXZ61_RS20430	COG0784	Response regulator, receiver
EXZ61_RS20430	COG2205	protein histidine kinase activity
EXZ61_RS20430	COG5002	protein histidine kinase activity
EXZ61_RS20440	COG0667	Aldo Keto reductase
EXZ61_RS20455	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
EXZ61_RS20460	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
EXZ61_RS20480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
EXZ61_RS20495	COG0456	acetyltransferase
EXZ61_RS20500	COG0678	peroxiredoxin activity
EXZ61_RS20505	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
EXZ61_RS20510	COG0255	Belongs to the universal ribosomal protein uL29 family
EXZ61_RS20515	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
EXZ61_RS20520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
EXZ61_RS20525	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
EXZ61_RS20530	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
EXZ61_RS20535	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
EXZ61_RS20540	COG0089	rRNA binding
EXZ61_RS20545	COG0088	Forms part of the polypeptide exit tunnel
EXZ61_RS20550	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
EXZ61_RS20555	COG0051	transcription antitermination factor activity, RNA binding
EXZ61_RS20560	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
EXZ61_RS20565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXZ61_RS20570	COG0049	tRNA binding
EXZ61_RS20575	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
EXZ61_RS20580	COG1686	Belongs to the peptidase S11 family
EXZ61_RS20585	COG2945	thiolester hydrolase activity
EXZ61_RS20610	COG0598	Magnesium transport protein CorA
EXZ61_RS20615	COG3181	Tripartite tricarboxylate transporter family receptor
EXZ61_RS20625	COG0412	Dienelactone hydrolase
EXZ61_RS20630	COG1028	Short-chain dehydrogenase reductase Sdr
EXZ61_RS20635	COG2095	MarC family integral membrane protein
EXZ61_RS20650	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
EXZ61_RS20665	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
EXZ61_RS20670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
EXZ61_RS20675	COG1024	Enoyl-CoA hydratase
EXZ61_RS20695	COG0768	penicillin binding
EXZ61_RS20700	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
EXZ61_RS20710	COG1077	Cell shape determining protein MreB Mrl
EXZ61_RS20715	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXZ61_RS20720	COG0154	amidase activity
EXZ61_RS20725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
EXZ61_RS20735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
EXZ61_RS20740	COG0708	Exodeoxyribonuclease III
EXZ61_RS20750	COG3239	Fatty acid desaturase
EXZ61_RS20755	COG4783	chaperone-mediated protein folding
EXZ61_RS20760	COG2807	transmembrane transport
EXZ61_RS20770	COG2205	protein histidine kinase activity
EXZ61_RS20775	COG0859	PFAM glycosyl transferase family 9
EXZ61_RS20800	COG0642	Histidine kinase
EXZ61_RS20805	COG0745	RESPONSE REGULATOR receiver
EXZ61_RS20810	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
EXZ61_RS20820	COG1858	cytochrome C peroxidase
EXZ61_RS20905	COG3501	Rhs element vgr protein
EXZ61_RS20910	COG4452	Inner membrane protein CreD
EXZ61_RS20920	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
EXZ61_RS20925	COG0477	Major facilitator Superfamily
EXZ61_RS20940	COG0386	Belongs to the glutathione peroxidase family
EXZ61_RS20945	COG0247	lactate metabolic process
EXZ61_RS20950	COG0277	FAD linked oxidase domain protein
EXZ61_RS20965	COG0004	ammonium transporteR
EXZ61_RS20970	COG0347	Belongs to the P(II) protein family
EXZ61_RS20975	COG0606	chelatase, subunit chli
EXZ61_RS21005	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
EXZ61_RS21020	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
EXZ61_RS21040	COG0210	DNA helicase
EXZ61_RS21110	COG3409	Peptidoglycan-binding domain 1 protein
EXZ61_RS21110	COG3267	Type II secretory pathway component ExeA
EXZ61_RS21170	COG1459	type II secretion system
EXZ61_RS21175	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
EXZ61_RS21180	COG1410	methionine synthase
EXZ61_RS21180	COG0646	methionine synthase
EXZ61_RS21200	COG0514	ATP-dependent DNA helicase (RecQ)
EXZ61_RS21210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
EXZ61_RS21215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
EXZ61_RS21220	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
EXZ61_RS21250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
EXZ61_RS21255	COG0697	spore germination
EXZ61_RS21270	COG3706	GGDEF domain
EXZ61_RS21275	COG0346	lactoylglutathione lyase activity
EXZ61_RS21280	COG0583	DNA-binding transcription factor activity
EXZ61_RS21285	COG1280	lysine exporter protein (LysE YggA)
EXZ61_RS21295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
EXZ61_RS21295	COG3453	Protein conserved in bacteria
EXZ61_RS21345	COG1024	Enoyl-CoA hydratase
EXZ61_RS21350	COG0446	pyridine nucleotide-disulphide oxidoreductase
EXZ61_RS21350	COG1902	pentaerythritol trinitrate reductase activity
EXZ61_RS21355	COG1695	Transcriptional regulator
EXZ61_RS21385	COG0784	Response regulator, receiver
EXZ61_RS21385	COG2205	protein histidine kinase activity
EXZ61_RS21385	COG5002	protein histidine kinase activity
EXZ61_RS21390	COG0596	Alpha beta hydrolase
EXZ61_RS21415	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
EXZ61_RS21420	COG3395	kinase activity
EXZ61_RS21440	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
EXZ61_RS21445	COG1183	phosphatidylcholine synthase activity
EXZ61_RS21455	COG1595	DNA-templated transcription, initiation
EXZ61_RS21485	COG3135	benzoate transporter
EXZ61_RS21490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
EXZ61_RS21495	COG0824	Thioesterase
EXZ61_RS21500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
EXZ61_RS21535	COG0693	protein deglycase activity
EXZ61_RS21550	COG0457	Tetratricopeptide repeat
EXZ61_RS21550	COG3710	Transcriptional regulator
EXZ61_RS21565	COG0583	DNA-binding transcription factor activity
EXZ61_RS21570	COG2957	Belongs to the agmatine deiminase family
EXZ61_RS21585	COG2957	Belongs to the agmatine deiminase family
EXZ61_RS21590	COG0686	Belongs to the AlaDH PNT family
EXZ61_RS21595	COG2267	carboxylic ester hydrolase activity
EXZ61_RS21605	COG3622	Belongs to the hyi family
EXZ61_RS21610	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
EXZ61_RS21615	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
EXZ61_RS21620	COG0625	glutathione transferase activity
EXZ61_RS21625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
EXZ61_RS21625	COG1017	nitric oxide dioxygenase activity
EXZ61_RS21680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
EXZ61_RS21720	COG4716	Myosin-crossreactive antigen
EXZ61_RS21740	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
EXZ61_RS21760	COG3220	belongs to the UPF0276 family
EXZ61_RS21770	COG0724	RNA recognition motif
EXZ61_RS21775	COG4221	oxidoreductase activity
EXZ61_RS21785	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
EXZ61_RS21800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
EXZ61_RS21810	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
EXZ61_RS21815	COG0706	membrane insertase activity
EXZ61_RS21820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
EXZ61_RS21825	COG0594	ribonuclease P activity
EXZ61_RS21830	COG0230	Belongs to the bacterial ribosomal protein bL34 family
EXZ61_RS21905	COG0840	transmembrane signaling receptor activity