locus-tag	class	description
RB10002	COG1063	alcohol dehydrogenase
RB10006	COG0259	pyridoxamine-phosphate oxidase activity
RB10007	COG1678	Uncharacterized ACR, COG1678
RB10025	COG1305	Transglutaminase-like
RB10030	COG2308	Evidence 4 Homologs of previously reported genes of
RB10049	COG1595	DNA-templated transcription, initiation
RB1005	COG1215	transferase activity, transferring glycosyl groups
RB10060	COG0640	Transcriptional regulator
RB10062	COG0579	oxidoreductase
RB10081	COG1132	(ABC) transporter
RB10088	COG3253	May function as heme-dependent peroxidase
RB10099	COG4968	Prepilin-type N-terminal cleavage methylation domain
RB10106	COG1324	tolerance protein
RB10112	COG0107	imidazoleglycerol-phosphate synthase activity
RB10113	COG0138	bifunctional purine biosynthesis protein purh
RB10114	COG0134	indole-3-glycerol-phosphate synthase activity
RB10116	COG3119	arylsulfatase activity
RB10119	COG0515	serine threonine protein kinase
RB10119	COG2815	serine threonine protein kinase
RB10129	COG0545	Peptidyl-prolyl cis-trans isomerase
RB10133	COG2815	serine threonine protein kinase
RB10133	COG0515	serine threonine protein kinase
RB10134	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RB10140	COG0659	secondary active sulfate transmembrane transporter activity
RB10144	COG2755	lipolytic protein G-D-S-L family
RB10144	COG0657	acetylesterase activity
RB10170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RB10172	COG1012	belongs to the aldehyde dehydrogenase family
RB10177	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
RB10180	COG1164	Oligoendopeptidase f
RB10181	COG1129	ABC transporter
RB10188	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RB10192	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RB10206	COG0356	it plays a direct role in the translocation of protons across the membrane
RB10209	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RB10211	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RB10213	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RB10215	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RB10216	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RB10217	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RB10219	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RB10227	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB10232	COG3119	arylsulfatase activity
RB10235	COG1335	isochorismatase
RB10245	COG0596	Alpha beta hydrolase
RB10258	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RB10261	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RB10264	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RB10266	COG0673	inositol 2-dehydrogenase activity
RB1027	COG0438	transferase activity, transferring glycosyl groups
RB10271	COG0328	RNA-DNA hybrid ribonuclease activity
RB10272	COG1028	Short-chain dehydrogenase reductase Sdr
RB10275	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RB10277	COG0469	pyruvate kinase activity
RB10279	COG0071	Belongs to the small heat shock protein (HSP20) family
RB10283	COG0071	Belongs to the small heat shock protein (HSP20) family
RB10295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RB10297	COG1795	PFAM Formaldehyde-activating enzyme (Fae)
RB10300	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
RB10309	COG2814	Major facilitator Superfamily
RB10310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RB10313	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RB10314	COG3002	Belongs to the UPF0753 family
RB10322	COG3852	Histidine kinase
RB10323	COG2204	response regulator
RB10326	COG0659	secondary active sulfate transmembrane transporter activity
RB10329	COG0515	serine threonine protein kinase
RB10329	COG2815	serine threonine protein kinase
RB10333	COG0515	serine threonine protein kinase
RB10335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RB10359	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RB10370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RB10374	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RB1039	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RB10436	COG0297	glycogen (starch) synthase activity
RB10439	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RB10442	COG1032	radical SAM domain protein
RB10458	COG0724	RNA recognition motif
RB10459	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RB1046	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RB10465	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RB10466	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RB10468	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RB10469	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RB10487	COG0514	ATP-dependent DNA helicase (RecQ)
RB10500	COG0126	phosphoglycerate kinase activity
RB10507	COG1082	Xylose isomerase domain protein TIM barrel
RB10508	COG1058	Belongs to the CinA family
RB10508	COG1546	Belongs to the CinA family
RB10510	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RB10517	COG0714	Associated with various cellular activities
RB10524	COG2183	response to ionizing radiation
RB10533	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RB10533	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
RB10536	COG2088	sporulation resulting in formation of a cellular spore
RB10537	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RB10539	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RB10547	COG0423	glycine-tRNA ligase activity
RB10553	COG2009	succinate dehydrogenase
RB10554	COG1053	succinate dehydrogenase
RB10555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RB10566	COG2610	gluconate transmembrane transporter activity
RB10567	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RB10592	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RB10599	COG3119	arylsulfatase activity
RB10612	COG3119	arylsulfatase activity
RB10616	COG2721	sulfolactate sulfo-lyase activity
RB10617	COG0045	succinate-CoA ligase (ADP-forming) activity
RB10619	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RB10627	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RB10629	COG0459	protein refolding
RB10638	COG0052	Belongs to the universal ribosomal protein uS2 family
RB10640	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RB10644	COG1256	bacterial-type flagellum assembly
RB10644	COG4786	Flagellar basal body rod
RB1065	COG0347	Belongs to the P(II) protein family
RB10650	COG0133	tryptophan synthase activity
RB10653	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RB10654	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RB10663	COG0420	3'-5' exonuclease activity
RB10683	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RB10693	COG1115	amino acid carrier protein
RB10711	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RB10721	COG1511	domain protein
RB10721	COG3264	Mechanosensitive ion channel
RB10727	COG3546	catalase activity
RB1074	COG1172	Belongs to the binding-protein-dependent transport system permease family
RB10767	COG0732	type I restriction modification DNA specificity domain
RB10770	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RB10787	COG2379	hydroxypyruvate reductase
RB1079	COG0563	adenylate kinase activity
RB10790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RB10797	COG0400	carboxylic ester hydrolase activity
RB10805	COG1454	alcohol dehydrogenase
RB10816	COG0470	DNA polymerase III
RB10817	COG0698	ribose 5-phosphate isomerase
RB10818	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RB10826	COG0740	serine-type endopeptidase activity
RB10829	COG0740	serine-type endopeptidase activity
RB10834	COG0165	Argininosuccinate lyase
RB10852	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RB10855	COG4948	Mandelate Racemase Muconate Lactonizing
RB10876	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RB10878	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RB10880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RB10883	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
RB10887	COG2192	nodulation
RB10892	COG0004	ammonium transporteR
RB10894	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RB10909	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RB10911	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RB1092	COG1250	3-hydroxyacyl-CoA dehydrogenase
RB1092	COG1024	Enoyl-CoA hydratase
RB10921	COG5564	TIM-barrel signal transduction protein
RB10922	COG5441	Belongs to the UPF0261 family
RB10934	COG3237	CsbD-like
RB10967	COG2130	NADP-dependent
RB10968	COG1012	belongs to the aldehyde dehydrogenase family
RB10971	COG0300	oxidoreductase activity
RB10984	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RB10985	COG1418	mRNA catabolic process
RB10987	COG0384	phenazine biosynthesis protein PhzF
RB10995	COG0515	serine threonine protein kinase
RB10996	COG1819	glycosyl
RB110	COG3119	arylsulfatase activity
RB11009	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RB11021	COG0577	efflux transmembrane transporter activity
RB11021	COG1136	(ABC) transporter
RB11027	COG0577	efflux transmembrane transporter activity
RB11027	COG1136	(ABC) transporter
RB11030	COG1136	(ABC) transporter
RB11030	COG0577	efflux transmembrane transporter activity
RB11050	COG1283	sodium-dependent phosphate transmembrane transporter activity
RB11063	COG0288	reversible hydration of carbon dioxide
RB11077	COG1959	2 iron, 2 sulfur cluster binding
RB11090	COG0745	RESPONSE REGULATOR receiver
RB11091	COG0784	Response regulator, receiver
RB11091	COG4191	Histidine kinase
RB11100	COG1321	iron dependent repressor
RB11112	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RB11118	COG4948	Mandelate Racemase Muconate Lactonizing
RB11123	COG3119	arylsulfatase activity
RB11127	COG3119	arylsulfatase activity
RB11133	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB11133	COG5549	protein import
RB11136	COG0515	serine threonine protein kinase
RB11136	COG2815	serine threonine protein kinase
RB11150	COG1902	pentaerythritol trinitrate reductase activity
RB11151	COG1064	alcohol dehydrogenase
RB11152	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RB11157	COG1393	Belongs to the ArsC family
RB11165	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RB11167	COG3005	denitrification pathway
RB11174	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RB11174	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RB11183	COG0589	response to stress
RB11186	COG2204	response regulator
RB11191	COG3852	Histidine kinase
RB11194	COG2824	Alkylphosphonate utilization operon protein PhnA
RB11201	COG0784	Response regulator, receiver
RB11203	COG4251	negative regulation of phosphorylation
RB11205	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RB11207	COG0398	Pfam SNARE associated Golgi protein
RB11219	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RB11225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RB11242	COG1595	DNA-templated transcription, initiation
RB11244	COG0515	serine threonine protein kinase
RB11255	COG4589	Belongs to the CDS family
RB11260	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RB11266	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RB11269	COG3258	Cytochrome c
RB11273	COG2814	Major facilitator Superfamily
RB1129	COG3002	Belongs to the UPF0753 family
RB11313	COG3012	SEC-C Motif Domain Protein
RB11321	COG3903	Transcriptional regulator
RB11321	COG3629	intracellular signal transduction
RB11334	COG0515	serine threonine protein kinase
RB11334	COG0457	Tetratricopeptide repeat
RB1134	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RB11371	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
RB11379	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RB1140	COG4566	intracellular signal transduction
RB11401	COG1061	Type III restriction enzyme res subunit
RB11407	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RB11411	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RB11438	COG0653	protein targeting
RB11482	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RB11494	COG0702	epimerase
RB11497	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RB11498	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RB115	COG4968	Prepilin-type N-terminal cleavage methylation domain
RB11502	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RB11510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RB11512	COG0384	phenazine biosynthesis protein PhzF
RB11516	COG1418	mRNA catabolic process
RB11550	COG0778	Nitroreductase
RB11563	COG1131	(ABC) transporter
RB11564	COG0842	Transport permease protein
RB11564	COG1511	domain protein
RB11579	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RB11587	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RB11594	COG0745	RESPONSE REGULATOR receiver
RB11595	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB11597	COG1459	type II secretion system
RB11604	COG2202	Pas domain
RB11604	COG2205	protein histidine kinase activity
RB11622	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
RB11626	COG0653	protein targeting
RB1164	COG0848	biopolymer transport protein
RB1165	COG0811	peptide transport
RB11650	COG0673	inositol 2-dehydrogenase activity
RB11663	COG2814	Major facilitator Superfamily
RB11669	COG2204	response regulator
RB11673	COG0481	GTPase activity
RB11688	COG1519	Transferase
RB11690	COG0653	protein targeting
RB11693	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RB11706	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB11712	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RB11756	COG2226	methyltransferase
RB11811	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RB11822	COG0516	GMP reductase activity
RB11822	COG0517	IMP dehydrogenase activity
RB11832	COG0105	UTP biosynthetic process
RB11847	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RB11853	COG0302	gtp cyclohydrolase
RB11856	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB11859	COG0321	lipoyl(octanoyl) transferase activity
RB11859	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RB11863	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RB11876	COG4232	protein-disulfide reductase activity
RB11877	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RB11878	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RB11879	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB11882	COG0295	cytidine deaminase activity
RB11913	COG0714	Associated with various cellular activities
RB11916	COG1305	Transglutaminase-like
RB11919	COG0129	dihydroxy-acid dehydratase activity
RB1192	COG4974	Belongs to the 'phage' integrase family
RB11920	COG2738	Putative neutral zinc metallopeptidase
RB11922	COG2322	membrane
RB11923	COG1999	signal sequence binding
RB11927	COG0657	acetylesterase activity
RB11930	COG1131	(ABC) transporter
RB11931	COG0109	protoheme IX farnesyltransferase activity
RB11941	COG1215	transferase activity, transferring glycosyl groups
RB11943	COG1233	COG1233 Phytoene dehydrogenase and related
RB11945	COG1012	belongs to the aldehyde dehydrogenase family
RB11947	COG2204	response regulator
RB11955	COG2815	serine threonine protein kinase
RB11955	COG0515	serine threonine protein kinase
RB11958	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RB11959	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RB11975	COG3321	synthase
RB11975	COG0604	alcohol dehydrogenase
RB11976	COG0745	RESPONSE REGULATOR receiver
RB11981	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RB11983	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RB11985	COG1028	Short-chain dehydrogenase reductase Sdr
RB11985	COG0604	alcohol dehydrogenase
RB11985	COG3321	synthase
RB11986	COG0784	Response regulator, receiver
RB11986	COG2205	protein histidine kinase activity
RB11986	COG5002	protein histidine kinase activity
RB11988	COG2815	serine threonine protein kinase
RB11988	COG0515	serine threonine protein kinase
RB11991	COG0123	including yeast histone deacetylase and acetoin utilization protein
RB11998	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RB12002	COG2045	Belongs to the ComB family
RB12007	COG0415	Belongs to the DNA photolyase family
RB12012	COG1070	Carbohydrate kinase
RB12013	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RB12019	COG0667	Aldo Keto reductase
RB12038	COG0673	inositol 2-dehydrogenase activity
RB12039	COG0277	FAD linked oxidase domain protein
RB12040	COG0277	FAD linked oxidase domain protein
RB12042	COG0247	lactate metabolic process
RB12047	COG0513	Belongs to the DEAD box helicase family
RB1205	COG3119	arylsulfatase activity
RB12053	COG0848	biopolymer transport protein
RB12055	COG0811	peptide transport
RB12061	COG0504	CTP synthase activity
RB12080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RB12081	COG0248	Ppx GppA phosphatase
RB12087	COG0129	dihydroxy-acid dehydratase activity
RB12089	COG3119	arylsulfatase activity
RB12092	COG3119	arylsulfatase activity
RB12107	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RB12108	COG2204	response regulator
RB12113	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RB12116	COG2176	DNA-directed DNA polymerase activity
RB1212	COG2239	Acts as a magnesium transporter
RB12129	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RB1213	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RB12133	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RB12137	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RB12138	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RB12145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RB12148	COG0793	Belongs to the peptidase S41A family
RB12160	COG3118	belongs to the thioredoxin family
RB12164	COG0494	nUDIX hydrolase
RB12174	COG1706	bacterial-type flagellum-dependent cell motility
RB12175	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RB12180	COG4786	Flagellar basal body rod
RB12181	COG1749	Flagellar hook protein flgE
RB12194	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RB12197	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RB12251	COG1595	DNA-templated transcription, initiation
RB12256	COG0671	phosphoesterase, PA-phosphatase related
RB12262	COG1017	nitric oxide dioxygenase activity
RB12262	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RB12279	COG0668	transmembrane transport
RB12282	COG0628	permease
RB12285	COG3963	phosphatidate phosphatase activity
RB12296	COG0300	oxidoreductase activity
RB1231	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RB12315	COG0110	maltose O-acetyltransferase activity
RB12325	COG3119	arylsulfatase activity
RB12326	COG0745	RESPONSE REGULATOR receiver
RB12326	COG4191	Histidine kinase
RB12326	COG2205	protein histidine kinase activity
RB12327	COG3104	oligopeptide transport
RB1233	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RB12337	COG1505	serine-type exopeptidase activity
RB12343	COG0366	Alpha amylase catalytic
RB12344	COG0438	transferase activity, transferring glycosyl groups
RB1235	COG0673	inositol 2-dehydrogenase activity
RB12360	COG1621	beta-fructofuranosidase activity
RB12361	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RB12372	COG1595	DNA-templated transcription, initiation
RB12377	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RB12381	COG0148	phosphopyruvate hydratase activity
RB12406	COG2211	Major facilitator Superfamily
RB12424	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RB12431	COG3119	arylsulfatase activity
RB12432	COG3119	arylsulfatase activity
RB12436	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RB12437	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RB12437	COG1321	iron dependent repressor
RB12438	COG1121	(ABC) transporter
RB12440	COG0803	Belongs to the bacterial solute-binding protein 9 family
RB12445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RB1248	COG1131	(ABC) transporter
RB12480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RB12480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RB12486	COG0515	serine threonine protein kinase
RB12500	COG1157	protein secretion by the type III secretion system
RB12502	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RB12509	COG4585	Histidine kinase
RB12510	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
RB12549	COG0116	Belongs to the methyltransferase superfamily
RB12559	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RB12564	COG0673	inositol 2-dehydrogenase activity
RB12572	COG0515	serine threonine protein kinase
RB12572	COG0457	Tetratricopeptide repeat
RB12590	COG0438	transferase activity, transferring glycosyl groups
RB12597	COG0473	3-isopropylmalate dehydrogenase activity
RB12598	COG0575	Belongs to the CDS family
RB12606	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RB12614	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RB1262	COG0587	DNA-directed DNA polymerase activity
RB12623	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RB12625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RB12626	COG0202	RNA polymerase activity
RB12628	COG0203	ribosomal protein L17
RB12638	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RB12652	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RB12656	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RB12658	COG0066	3-isopropylmalate dehydratase activity
RB12661	COG0284	orotidine-5'-phosphate decarboxylase activity
RB12666	COG0437	4 iron, 4 sulfur cluster binding
RB12690	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RB12694	COG0515	serine threonine protein kinase
RB12694	COG2815	serine threonine protein kinase
RB12718	COG0617	tRNA 3'-terminal CCA addition
RB1272	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB12724	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RB12730	COG1595	DNA-templated transcription, initiation
RB1274	COG1902	pentaerythritol trinitrate reductase activity
RB12740	COG3386	PFAM SMP-30 Gluconolaconase
RB12745	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RB12752	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB12756	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RB12762	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RB12766	COG2202	Pas domain
RB12766	COG2200	EAL domain
RB12766	COG2199	diguanylate cyclase activity
RB12768	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB12774	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB12781	COG1459	type II secretion system
RB12799	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RB12799	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RB128	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB12812	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RB12816	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RB12821	COG0335	large ribosomal subunit rRNA binding
RB12823	COG0336	Belongs to the RNA methyltransferase TrmD family
RB12824	COG0228	four-way junction DNA binding
RB12825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RB12831	COG0463	Glycosyl transferase, family 2
RB12839	COG0081	regulation of translation
RB12840	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RB12842	COG0222	ribosome binding
RB12854	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RB12856	COG0242	peptide deformylase activity
RB12858	COG4608	Belongs to the ABC transporter superfamily
RB12859	COG0444	Belongs to the ABC transporter superfamily
RB1286	COG5433	transposase activity
RB12860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RB12861	COG0601	transmembrane transport
RB12864	COG1448	Aminotransferase
RB12866	COG3228	Belongs to the MtfA family
RB12881	COG0745	RESPONSE REGULATOR receiver
RB12885	COG0564	pseudouridine synthase activity
RB12886	COG0861	Integral membrane protein TerC family
RB12904	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RB12905	COG0028	Belongs to the TPP enzyme family
RB12907	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RB12924	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RB12934	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RB12949	COG3852	Histidine kinase
RB12952	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RB12963	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RB130	COG2165	general secretion pathway protein
RB13025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RB13026	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RB13037	COG0714	Associated with various cellular activities
RB13071	COG1192	Involved in chromosome partitioning
RB1308	COG0493	'glutamate synthase
RB13091	COG0523	cobalamin synthesis protein
RB13094	COG0523	cobalamin synthesis protein
RB1310	COG1131	(ABC) transporter
RB13104	COG4964	Belongs to the GSP D family
RB13110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RB13112	COG2205	protein histidine kinase activity
RB13112	COG0784	Response regulator, receiver
RB13140	COG2084	Dehydrogenase
RB13147	COG3119	arylsulfatase activity
RB13148	COG3119	arylsulfatase activity
RB13155	COG3119	arylsulfatase activity
RB13157	COG3119	arylsulfatase activity
RB13165	COG2207	Transcriptional regulator
RB13165	COG1609	Transcriptional regulator
RB1317	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RB13175	COG2205	protein histidine kinase activity
RB13175	COG0784	Response regulator, receiver
RB13181	COG5002	protein histidine kinase activity
RB13181	COG2198	Histidine kinase
RB13181	COG0784	Response regulator, receiver
RB1319	COG0525	valine-tRNA ligase activity
RB13193	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB1321	COG1940	carbohydrate kinase activity
RB13211	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RB13217	COG3682	Transcriptional regulator
RB13224	COG0702	epimerase
RB13225	COG0514	ATP-dependent DNA helicase (RecQ)
RB1325	COG4555	ABC transporter
RB13260	COG0604	alcohol dehydrogenase
RB13261	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RB13263	COG0017	Asparaginyl-tRNA synthetase
RB13264	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RB13271	COG1181	Belongs to the D-alanine--D-alanine ligase family
RB133	COG2321	neutral zinc metallopeptidase
RB13301	COG0540	Belongs to the ATCase OTCase family
RB13303	COG0367	asparagine synthase
RB13306	COG1335	isochorismatase
RB1342	COG1338	Plays a role in the flagellum-specific transport system
RB1347	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RB1353	COG1914	H( )-stimulated, divalent metal cation uptake system
RB1355	COG0363	glucosamine-6-phosphate deaminase activity
RB1356	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RB1357	COG3706	GGDEF domain
RB1358	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RB1363	COG0686	Belongs to the AlaDH PNT family
RB1367	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
RB1371	COG0616	signal peptide processing
RB1392	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RB1411	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB1427	COG0651	ATP synthesis coupled electron transport
RB1430	COG0651	ATP synthesis coupled electron transport
RB1431	COG0651	ATP synthesis coupled electron transport
RB1436	COG1320	monovalent cation:proton antiporter activity
RB1439	COG2212	antiporter activity
RB1454	COG1609	Transcriptional regulator
RB1454	COG2207	Transcriptional regulator
RB1456	COG3119	arylsulfatase activity
RB146	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB1464	COG3119	arylsulfatase activity
RB1477	COG3119	arylsulfatase activity
RB1481	COG2258	MOSC domain
RB1483	COG4251	negative regulation of phosphorylation
RB1485	COG1796	DNA polymerase
RB1485	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
RB1499	COG0714	Associated with various cellular activities
RB1507	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RB1517	COG1136	(ABC) transporter
RB1529	COG1032	radical SAM domain protein
RB1532	COG0515	serine threonine protein kinase
RB1545	COG4796	Type ii and iii secretion system protein
RB1561	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RB1571	COG1793	dna ligase
RB1577	COG1201	RNA secondary structure unwinding
RB1578	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RB1579	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RB1584	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RB1586	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RB1588	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RB159	COG2205	protein histidine kinase activity
RB159	COG3437	response regulator, receiver
RB159	COG3850	Histidine kinase
RB159	COG4999	Histidine kinase
RB1591	COG1233	COG1233 Phytoene dehydrogenase and related
RB1597	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
RB1604	COG4335	DNA alkylation repair
RB1606	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RB1606	COG2169	Transcriptional regulator
RB1608	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
RB161	COG3437	response regulator, receiver
RB1629	COG1940	carbohydrate kinase activity
RB1630	COG0481	GTPase activity
RB1637	COG0463	Glycosyl transferase, family 2
RB1688	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB1696	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RB1703	COG0424	maF-like protein
RB1706	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RB1708	COG0305	Participates in initiation and elongation during chromosome replication
RB1711	COG2204	response regulator
RB1736	COG3119	arylsulfatase activity
RB1739	COG1305	Transglutaminase-like
RB1759	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
RB1784	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RB1798	COG0714	Associated with various cellular activities
RB1821	COG0515	serine threonine protein kinase
RB1821	COG2815	serine threonine protein kinase
RB1831	COG1726	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RB1832	COG1805	sodium ion transport
RB1833	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RB1835	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RB1836	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
RB1839	COG1477	protein flavinylation
RB1840	COG0736	holo-[acyl-carrier-protein] synthase activity
RB1856	COG0113	porphobilinogen synthase activity
RB1862	COG1725	Transcriptional regulator
RB1866	COG1131	(ABC) transporter
RB1893	COG2815	serine threonine protein kinase
RB1893	COG0515	serine threonine protein kinase
RB1895	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
RB1898	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RB1902	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RB1934	COG0737	Belongs to the 5'-nucleotidase family
RB1964	COG0202	RNA polymerase activity
RB1970	COG0343	queuine tRNA-ribosyltransferase activity
RB1977	COG1793	dna ligase
RB1977	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RB1993	COG0617	tRNA 3'-terminal CCA addition
RB1998	COG0574	Belongs to the PEP-utilizing enzyme family
RB1998	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RB200	COG3119	arylsulfatase activity
RB2008	COG4251	negative regulation of phosphorylation
RB201	COG1082	Xylose isomerase domain protein TIM barrel
RB2013	COG0653	protein targeting
RB2022	COG1692	metallophosphoesterase
RB2024	COG0539	negative regulation of cytoplasmic translation
RB203	COG0656	L-ascorbic acid biosynthetic process
RB2062	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB2066	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB2081	COG0823	Involved in the tonB-independent uptake of proteins
RB2081	COG1506	peptidase
RB2085	COG3119	arylsulfatase activity
RB2098	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
RB2110	COG0534	Mate efflux family protein
RB2114	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RB2115	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
RB2118	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RB2121	COG2326	polyphosphate kinase activity
RB2135	COG3119	arylsulfatase activity
RB2141	COG0564	pseudouridine synthase activity
RB2142	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RB2143	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RB2144	COG0142	geranyltranstransferase activity
RB2146	COG1722	exodeoxyribonuclease VII activity
RB2152	COG2816	NAD+ diphosphatase activity
RB2160	COG1449	Belongs to the glycosyl hydrolase 57 family
RB2174	COG0745	RESPONSE REGULATOR receiver
RB2204	COG1192	Involved in chromosome partitioning
RB2238	COG1017	nitric oxide dioxygenase activity
RB2238	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RB2239	COG0300	oxidoreductase activity
RB2244	COG0386	Belongs to the glutathione peroxidase family
RB2253	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
RB2254	COG3119	arylsulfatase activity
RB2264	COG1970	mechanosensitive ion channel activity
RB2278	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RB2291	COG1192	Involved in chromosome partitioning
RB2296	COG1475	DNA binding
RB2367	COG3119	arylsulfatase activity
RB2373	COG1063	alcohol dehydrogenase
RB2381	COG1538	Outer membrane efflux protein
RB2386	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB2396	COG2204	response regulator
RB2403	COG0246	Mannitol dehydrogenase
RB2429	COG0443	Heat shock 70 kDa protein
RB2440	COG2133	pyrroloquinoline quinone binding
RB2464	COG3206	protein involved in exopolysaccharide biosynthesis
RB2464	COG0489	protein tyrosine kinase activity
RB2470	COG0110	maltose O-acetyltransferase activity
RB2475	COG5433	transposase activity
RB2479	COG0275	rRNA processing
RB2484	COG0297	glycogen (starch) synthase activity
RB251	COG0124	histidyl-tRNA synthetase
RB2512	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RB2518	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RB2521	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RB2532	COG0363	glucosamine-6-phosphate deaminase activity
RB2535	COG1609	Transcriptional regulator
RB2543	COG0539	negative regulation of cytoplasmic translation
RB2543	COG2183	response to ionizing radiation
RB2549	COG4251	negative regulation of phosphorylation
RB2550	COG2201	protein-glutamate methylesterase activity
RB2552	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RB2558	COG4974	Belongs to the 'phage' integrase family
RB256	COG0788	formyltetrahydrofolate deformylase activity
RB2568	COG0235	Class ii aldolase
RB2581	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
RB2582	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RB2585	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
RB2588	COG4869	propanediol catabolic process
RB2590	COG1349	DNA-binding transcription factor activity
RB2613	COG3119	arylsulfatase activity
RB2619	COG0084	hydrolase, TatD family'
RB2627	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RB2630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RB2632	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RB2637	COG0328	RNA-DNA hybrid ribonuclease activity
RB2638	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RB264	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RB2642	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RB2645	COG0602	queuosine metabolic process
RB2651	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB2658	COG2115	Belongs to the xylose isomerase family
RB2661	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RB2663	COG3119	arylsulfatase activity
RB2673	COG2815	serine threonine protein kinase
RB2673	COG0515	serine threonine protein kinase
RB2676	COG0101	tRNA pseudouridine synthase activity
RB2701	COG3119	arylsulfatase activity
RB2707	COG3119	arylsulfatase activity
RB2710	COG0457	Tetratricopeptide repeat
RB2710	COG0705	Rhomboid family
RB2731	COG2204	response regulator
RB2732	COG3119	arylsulfatase activity
RB2735	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RB2743	COG2197	response regulator
RB2746	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB2748	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RB2750	COG0163	prenyltransferase activity
RB2752	COG2226	methyltransferase
RB2754	COG0546	phosphoglycolate phosphatase activity
RB2774	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RB2780	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RB2788	COG1301	dicarboxylic acid transport
RB279	COG1131	(ABC) transporter
RB281	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RB2817	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
RB282	COG4956	integral membrane protein (PIN domain superfamily)
RB2825	COG0584	glycerophosphoryl diester phosphodiesterase
RB284	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RB2840	COG1595	DNA-templated transcription, initiation
RB2855	COG0515	serine threonine protein kinase
RB2855	COG2815	serine threonine protein kinase
RB2872	COG4251	negative regulation of phosphorylation
RB2884	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RB2895	COG0848	biopolymer transport protein
RB2905	COG1774	PSP1 C-terminal conserved region
RB293	COG0746	molybdenum cofactor guanylyltransferase activity
RB2934	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RB295	COG0303	'Molybdopterin
RB2966	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB2968	COG1162	GTPase activity
RB297	COG0004	ammonium transporteR
RB2971	COG1082	Xylose isomerase domain protein TIM barrel
RB2974	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RB2975	COG0347	Belongs to the P(II) protein family
RB2976	COG2096	Adenosyltransferase
RB2978	COG1051	belongs to the nudix hydrolase family
RB2985	COG0438	transferase activity, transferring glycosyl groups
RB2986	COG0366	Alpha amylase catalytic
RB2992	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RB301	COG1194	a g-specific adenine glycosylase
RB3010	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RB3016	COG0393	Putative heavy-metal-binding
RB3023	COG0750	zinc metalloprotease
RB304	COG1858	cytochrome C peroxidase
RB3053	COG2020	methyltransferase activity
RB3065	COG2226	methyltransferase
RB3070	COG0673	inositol 2-dehydrogenase activity
RB3103	COG0587	DNA-directed DNA polymerase activity
RB3109	COG1858	cytochrome C peroxidase
RB314	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RB3144	COG4974	Belongs to the 'phage' integrase family
RB316	COG1028	Short-chain dehydrogenase reductase Sdr
RB3174	COG1187	pseudouridine synthase activity
RB3177	COG3119	arylsulfatase activity
RB318	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RB3193	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RB3195	COG0793	Belongs to the peptidase S41A family
RB320	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RB3217	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
RB3221	COG4260	virion core protein, lumpy skin disease virus
RB3236	COG0471	metal ion transport
RB3239	COG1082	Xylose isomerase domain protein TIM barrel
RB3253	COG1131	(ABC) transporter
RB3255	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RB3266	COG0564	pseudouridine synthase activity
RB3271	COG0457	Tetratricopeptide repeat
RB3271	COG0515	serine threonine protein kinase
RB3272	COG0187	DNA topoisomerase II activity
RB328	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RB3283	COG0727	PFAM Uncharacterised protein family (UPF0153)
RB3287	COG3842	ATPase activity
RB3292	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RB3309	COG3119	arylsulfatase activity
RB3312	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RB3314	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB3317	COG0673	inositol 2-dehydrogenase activity
RB3340	COG0363	glucosamine-6-phosphate deaminase activity
RB3345	COG4977	sequence-specific DNA binding
RB3345	COG1917	Cupin 2, conserved barrel domain protein
RB3349	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB3352	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB3363	COG2197	response regulator
RB3373	COG2205	protein histidine kinase activity
RB3373	COG0784	Response regulator, receiver
RB3373	COG5002	protein histidine kinase activity
RB339	COG0011	TIGRFAM Protein of
RB3405	COG3250	beta-galactosidase activity
RB3413	COG0657	acetylesterase activity
RB342	COG0545	Peptidyl-prolyl cis-trans isomerase
RB3423	COG0508	dehydrogenase complex catalyzes the overall conversion of
RB3427	COG0717	Belongs to the dCTP deaminase family
RB3431	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RB3442	COG0673	inositol 2-dehydrogenase activity
RB3446	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RB3451	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RB3453	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RB3465	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RB3466	COG0187	DNA topoisomerase II activity
RB3471	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RB3478	COG0024	Methionine aminopeptidase
RB348	COG3119	arylsulfatase activity
RB3482	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RB3484	COG1459	type II secretion system
RB3488	COG1063	alcohol dehydrogenase
RB3491	COG1869	D-ribose catabolic process
RB3493	COG1879	ABC-type sugar transport system periplasmic component
RB3496	COG1129	ABC transporter
RB3497	COG1172	Belongs to the binding-protein-dependent transport system permease family
RB3499	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RB3508	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RB352	COG3119	arylsulfatase activity
RB3549	COG2207	Transcriptional regulator
RB3550	COG2755	lipolytic protein G-D-S-L family
RB3550	COG0657	acetylesterase activity
RB3555	COG1940	carbohydrate kinase activity
RB3556	COG0363	glucosamine-6-phosphate deaminase activity
RB3591	COG0438	transferase activity, transferring glycosyl groups
RB3596	COG0822	iron-sulfur transferase activity
RB3597	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RB3598	COG1570	exodeoxyribonuclease VII activity
RB3605	COG3300	MHYT domain
RB3605	COG5001	Diguanylate cyclase
RB3606	COG2202	Pas domain
RB3606	COG3920	Histidine kinase
RB3614	COG2204	response regulator
RB3615	COG4191	Histidine kinase
RB3622	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RB3632	COG4221	oxidoreductase activity
RB3639	COG2755	lipolytic protein G-D-S-L family
RB3653	COG2207	Transcriptional regulator
RB3657	COG1028	Short-chain dehydrogenase reductase Sdr
RB3670	COG2801	Transposase and inactivated derivatives
RB3670	COG3415	Transposase
RB3678	COG1477	protein flavinylation
RB3680	COG1959	2 iron, 2 sulfur cluster binding
RB3681	COG2226	methyltransferase
RB3689	COG1335	isochorismatase
RB3698	COG1902	pentaerythritol trinitrate reductase activity
RB370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RB370	COG1116	anion transmembrane transporter activity
RB3702	COG0583	DNA-binding transcription factor activity
RB3706	COG1477	protein flavinylation
RB3708	COG1166	arginine decarboxylase activity
RB3710	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RB3710	COG3153	acetyltransferase
RB372	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RB3727	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RB3729	COG0577	efflux transmembrane transporter activity
RB3729	COG1136	(ABC) transporter
RB373	COG1116	anion transmembrane transporter activity
RB373	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RB3735	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RB374	COG1116	anion transmembrane transporter activity
RB3751	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RB3755	COG3119	arylsulfatase activity
RB3762	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RB3763	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RB3767	COG0473	3-isopropylmalate dehydrogenase activity
RB3768	COG2271	Major facilitator Superfamily
RB377	COG0437	4 iron, 4 sulfur cluster binding
RB3770	COG0673	inositol 2-dehydrogenase activity
RB378	COG0243	molybdopterin cofactor binding
RB3784	COG2204	response regulator
RB3788	COG1131	(ABC) transporter
RB379	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RB3792	COG5002	protein histidine kinase activity
RB380	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RB3816	COG2084	Dehydrogenase
RB3822	COG0688	phosphatidylethanolamine metabolic process
RB3824	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RB384	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
RB3849	COG3119	arylsulfatase activity
RB386	COG0318	PFAM AMP-dependent synthetase and ligase
RB3876	COG3119	arylsulfatase activity
RB3877	COG3119	arylsulfatase activity
RB3884	COG0528	UMP kinase activity
RB3886	COG0233	cytoplasmic translational termination
RB3891	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RB3893	COG0515	serine threonine protein kinase
RB3898	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
RB3908	COG0432	Pfam Uncharacterised protein family UPF0047
RB3913	COG0826	peptidase U32
RB3915	COG1573	uracil-dna glycosylase
RB392	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RB3932	COG0811	peptide transport
RB3936	COG0512	Glutamine amidotransferase of anthranilate synthase
RB3942	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RB3956	COG3119	arylsulfatase activity
RB3959	COG2050	protein possibly involved in aromatic compounds catabolism
RB3960	COG0471	metal ion transport
RB3960	COG3273	potassium ion transport
RB3967	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB399	COG0166	Belongs to the GPI family
RB3999	COG4974	Belongs to the 'phage' integrase family
RB4013	COG1643	Atp-dependent helicase
RB4017	COG3119	arylsulfatase activity
RB4024	COG2382	esterase
RB4031	COG2815	serine threonine protein kinase
RB4031	COG0515	serine threonine protein kinase
RB406	COG3119	arylsulfatase activity
RB406	COG3408	Glycogen debranching enzyme
RB4069	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RB4081	COG0714	Associated with various cellular activities
RB4087	COG1192	Involved in chromosome partitioning
RB409	COG3119	arylsulfatase activity
RB4091	COG5433	transposase activity
RB410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RB4105	COG2003	Belongs to the UPF0758 family
RB4113	COG5433	transposase activity
RB4115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RB4123	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
RB4131	COG1063	alcohol dehydrogenase
RB4136	COG0745	RESPONSE REGULATOR receiver
RB4137	COG4191	Histidine kinase
RB4143	COG0154	amidase activity
RB4156	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RB4160	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RB4173	COG0552	protein localization to endoplasmic reticulum
RB4179	COG2204	response regulator
RB4186	COG0515	serine threonine protein kinase
RB4224	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RB4229	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RB423	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RB4230	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RB4247	COG1643	Atp-dependent helicase
RB4267	COG3338	carbonate dehydratase activity
RB4269	COG3591	Belongs to the peptidase S1B family
RB4270	COG1864	DNA RNA non-specific endonuclease
RB4270	COG3591	Belongs to the peptidase S1B family
RB4288	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RB4292	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RB4305	COG1136	(ABC) transporter
RB4305	COG0577	efflux transmembrane transporter activity
RB4309	COG1136	(ABC) transporter
RB4309	COG0577	efflux transmembrane transporter activity
RB4310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB4327	COG0534	Mate efflux family protein
RB4333	COG0438	transferase activity, transferring glycosyl groups
RB4366	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RB4376	COG0753	catalase activity
RB4377	COG0628	permease
RB4382	COG1166	arginine decarboxylase activity
RB4386	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RB4394	COG0693	protein deglycase activity
RB4396	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RB4404	COG1028	Short-chain dehydrogenase reductase Sdr
RB4416	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RB4417	COG2010	Cytochrome c
RB4417	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RB4419	COG1285	pathogenesis
RB4420	COG0586	Pfam SNARE associated Golgi protein
RB4422	COG2205	protein histidine kinase activity
RB4422	COG0784	Response regulator, receiver
RB4423	COG0590	tRNA wobble adenosine to inosine editing
RB4432	COG1028	Short-chain dehydrogenase reductase Sdr
RB4433	COG0783	Belongs to the Dps family
RB4436	COG2261	transglycosylase associated protein
RB4438	COG3871	stress protein (general stress protein 26)
RB4454	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RB4459	COG0668	transmembrane transport
RB4474	COG3237	CsbD-like
RB4484	COG1473	amidohydrolase
RB4485	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
RB4487	COG2204	response regulator
RB4502	COG0401	homolog of Blt101
RB4506	COG1183	phosphatidylcholine synthase activity
RB4508	COG2201	protein-glutamate methylesterase activity
RB4513	COG1295	ribonuclease BN
RB4517	COG2154	pterin-4-alpha-carbinolamine dehydratase
RB4527	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RB4564	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB4577	COG0367	asparagine synthase
RB4579	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RB4582	COG1702	phosphate starvation-inducible protein PhoH
RB4583	COG0575	Belongs to the CDS family
RB4586	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RB4591	COG1381	Involved in DNA repair and RecF pathway recombination
RB460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RB4605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB4610	COG0632	four-way junction helicase activity
RB4611	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RB4613	COG0316	Belongs to the HesB IscA family
RB4629	COG3123	guanosine phosphorylase activity
RB4631	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RB4632	COG1862	Preprotein translocase
RB4633	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RB4638	COG3119	arylsulfatase activity
RB4646	COG1845	cytochrome c oxidase, subunit III
RB4651	COG2022	thiamine diphosphate biosynthetic process
RB4673	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RB4675	COG0215	cysteine-tRNA ligase activity
RB4681	COG1278	Cold shock
RB470	COG2801	Transposase and inactivated derivatives
RB4714	COG0714	Associated with various cellular activities
RB4715	COG3552	Protein containing von Willebrand factor type A (VWA) domain
RB4725	COG1028	Short-chain dehydrogenase reductase Sdr
RB4737	COG1830	Aldolase
RB4742	COG0589	response to stress
RB4758	COG3852	Histidine kinase
RB4759	COG4191	Histidine kinase
RB4760	COG0745	RESPONSE REGULATOR receiver
RB4770	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RB4784	COG3119	arylsulfatase activity
RB4815	COG3119	arylsulfatase activity
RB4851	COG3119	arylsulfatase activity
RB4864	COG0577	efflux transmembrane transporter activity
RB4864	COG1136	(ABC) transporter
RB4867	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RB4868	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RB4869	COG0490	domain, Protein
RB4869	COG2985	domain, Protein
RB4872	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB4880	COG3408	Glycogen debranching enzyme
RB4880	COG3119	arylsulfatase activity
RB4903	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
RB4906	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RB4915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RB4916	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RB4925	COG0571	ribonuclease III activity
RB4934	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RB4936	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RB4937	COG0673	inositol 2-dehydrogenase activity
RB4944	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RB4960	COG1242	4 iron, 4 sulfur cluster binding
RB4968	COG2267	carboxylic ester hydrolase activity
RB497	COG0714	Associated with various cellular activities
RB4981	COG1028	Short-chain dehydrogenase reductase Sdr
RB4982	COG0702	epimerase
RB4994	COG2205	protein histidine kinase activity
RB4995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RB4997	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RB5003	COG0004	ammonium transporteR
RB5028	COG2815	serine threonine protein kinase
RB5028	COG0515	serine threonine protein kinase
RB5029	COG2226	methyltransferase
RB5050	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RB5051	COG0492	ferredoxin-NADP+ reductase activity
RB5053	COG1082	Xylose isomerase domain protein TIM barrel
RB5055	COG0488	(ABC) transporter
RB5056	COG4555	ABC transporter
RB5084	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
RB5097	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RB5098	COG1045	serine acetyltransferase
RB5117	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RB5128	COG2010	Cytochrome c
RB5134	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RB5135	COG0720	synthase
RB5140	COG0673	inositol 2-dehydrogenase activity
RB5146	COG3119	arylsulfatase activity
RB5151	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RB5152	COG1137	ATPase activity
RB5175	COG1192	Involved in chromosome partitioning
RB5177	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RB5178	COG0442	prolyl-tRNA aminoacylation
RB5179	COG0505	Belongs to the CarA family
RB5191	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RB5197	COG0438	transferase activity, transferring glycosyl groups
RB5198	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RB5205	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RB5208	COG4285	Biotin-protein ligase, N terminal
RB5226	COG2818	Glycosylase
RB5245	COG1272	protein, Hemolysin III
RB5256	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
RB5259	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RB5277	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB5278	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RB5281	COG3119	arylsulfatase activity
RB5282	COG3119	arylsulfatase activity
RB5290	COG0673	inositol 2-dehydrogenase activity
RB5294	COG3119	arylsulfatase activity
RB5295	COG3119	arylsulfatase activity
RB5305	COG3119	arylsulfatase activity
RB5320	COG1063	alcohol dehydrogenase
RB5336	COG2146	nitrite reductase [NAD(P)H] activity
RB5343	COG1074	ATP-dependent DNA helicase activity
RB5356	COG4968	Prepilin-type N-terminal cleavage methylation domain
RB536	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RB5363	COG0655	NAD(P)H dehydrogenase (quinone) activity
RB5365	COG0673	inositol 2-dehydrogenase activity
RB5378	COG3119	arylsulfatase activity
RB5383	COG3119	arylsulfatase activity
RB539	COG1058	Belongs to the CinA family
RB539	COG1546	Belongs to the CinA family
RB5392	COG0287	Prephenate dehydrogenase
RB5395	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RB5405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RB5406	COG1070	Carbohydrate kinase
RB5414	COG0085	RNA polymerase activity
RB5416	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RB5417	COG3119	arylsulfatase activity
RB5424	COG3119	arylsulfatase activity
RB5434	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RB5437	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RB5444	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RB5465	COG2199	diguanylate cyclase activity
RB5472	COG0745	RESPONSE REGULATOR receiver
RB5479	COG5002	protein histidine kinase activity
RB5500	COG0217	transcriptional regulatory protein
RB5503	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RB5504	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RB5507	COG2251	uridine kinase activity
RB5507	COG0195	Participates in both transcription termination and antitermination
RB5540	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
RB5543	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RB5543	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RB5546	COG0438	transferase activity, transferring glycosyl groups
RB555	COG4941	Belongs to the sigma-70 factor family
RB5560	COG0159	tryptophan synthase activity
RB5566	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB5568	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RB5571	COG0750	zinc metalloprotease
RB5571	COG0750	zinc metalloprotease
RB5593	COG0457	Tetratricopeptide repeat
RB5593	COG0515	serine threonine protein kinase
RB560	COG3795	YCII-related domain
RB5601	COG0140	phosphoribosyl-ATP diphosphatase activity
RB5603	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RB5606	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RB5616	COG1073	alpha beta
RB5619	COG1160	GTP binding
RB5620	COG1573	uracil-dna glycosylase
RB563	COG3795	YCII-related domain
RB5630	COG1192	Involved in chromosome partitioning
RB5641	COG1757	Na H antiporter
RB5642	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RB5645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB5647	COG1032	radical SAM domain protein
RB5653	COG0493	'glutamate synthase
RB5654	COG0067	glutamate synthase
RB5654	COG0069	glutamate synthase activity
RB5654	COG0070	glutamate synthase
RB5655	COG0583	DNA-binding transcription factor activity
RB5674	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
RB5675	COG1678	Uncharacterized ACR, COG1678
RB5678	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RB5681	COG0544	peptidyl-prolyl cis-trans isomerase activity
RB5689	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RB5694	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RB5695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RB5701	COG0277	FAD linked oxidase domain protein
RB5701	COG0247	lactate metabolic process
RB5705	COG0314	molybdopterin synthase activity
RB5708	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RB5725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RB5730	COG1606	tRNA processing
RB5731	COG2815	serine threonine protein kinase
RB5731	COG0515	serine threonine protein kinase
RB5743	COG2081	HI0933 family
RB5747	COG0018	arginyl-trna synthetase
RB5753	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RB5754	COG0443	Heat shock 70 kDa protein
RB5758	COG0861	Integral membrane protein TerC family
RB5762	COG1694	Mazg nucleotide pyrophosphohydrolase
RB5766	COG1252	NADH dehydrogenase
RB5768	COG1511	domain protein
RB5768	COG3264	Mechanosensitive ion channel
RB5774	COG1690	Belongs to the RtcB family
RB5776	COG0673	inositol 2-dehydrogenase activity
RB5778	COG1785	Belongs to the alkaline phosphatase family
RB5780	COG0745	RESPONSE REGULATOR receiver
RB5801	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RB5804	COG1185	polyribonucleotide nucleotidyltransferase activity
RB5821	COG0738	Major facilitator superfamily
RB5824	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
RB5830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RB5847	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RB5861	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RB5861	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RB5871	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB5934	COG1657	PFAM Prenyltransferase squalene oxidase
RB5943	COG0745	RESPONSE REGULATOR receiver
RB5948	COG1063	alcohol dehydrogenase
RB5961	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
RB5964	COG3706	GGDEF domain
RB5969	COG0514	ATP-dependent DNA helicase (RecQ)
RB5971	COG1172	Belongs to the binding-protein-dependent transport system permease family
RB5972	COG1129	ABC transporter
RB5983	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RB5986	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RB5998	COG0698	ribose 5-phosphate isomerase
RB5999	COG4974	Belongs to the 'phage' integrase family
RB6040	COG4536	flavin adenine dinucleotide binding
RB6042	COG4536	flavin adenine dinucleotide binding
RB6049	COG0529	Catalyzes the synthesis of activated sulfate
RB605	COG3119	arylsulfatase activity
RB6056	COG0714	Associated with various cellular activities
RB6061	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RB6063	COG0598	Magnesium transport protein CorA
RB6065	COG1196	nuclear chromosome segregation
RB6078	COG1595	DNA-templated transcription, initiation
RB609	COG1073	alpha beta
RB6090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
RB6092	COG1994	Peptidase M50
RB6120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB6133	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RB6135	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RB6139	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
RB6142	COG0667	Aldo Keto reductase
RB6145	COG2819	hydrolase of the alpha beta superfamily
RB6166	COG4974	Belongs to the 'phage' integrase family
RB6167	COG0517	IMP dehydrogenase activity
RB6171	COG4974	Belongs to the 'phage' integrase family
RB6180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RB6196	COG3119	arylsulfatase activity
RB6199	COG0673	inositol 2-dehydrogenase activity
RB6201	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RB6215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RB6217	COG0745	RESPONSE REGULATOR receiver
RB6226	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RB6236	COG1131	(ABC) transporter
RB6238	COG1253	flavin adenine dinucleotide binding
RB6240	COG0300	oxidoreductase activity
RB6241	COG0297	glycogen (starch) synthase activity
RB6246	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RB6248	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RB6254	COG0662	Cupin 2, conserved barrel domain protein
RB6254	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
RB6259	COG0811	peptide transport
RB6269	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RB6271	COG4974	Belongs to the 'phage' integrase family
RB6272	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RB6278	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RB6285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RB6291	COG4864	UPF0365 protein
RB6302	COG0494	nUDIX hydrolase
RB6305	COG0463	Glycosyl transferase, family 2
RB6315	COG4566	intracellular signal transduction
RB6327	COG1028	Short-chain dehydrogenase reductase Sdr
RB6331	COG0352	thiamine-phosphate diphosphorylase activity
RB6344	COG0358	DNA primase activity
RB6347	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RB6350	COG3278	Belongs to the heme-copper respiratory oxidase family
RB6353	COG2010	Cytochrome c
RB6355	COG0348	domain, Protein
RB6360	COG2217	Heavy metal translocating P-type atpase
RB6370	COG2204	response regulator
RB6373	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RB6377	COG2943	transferase activity, transferring hexosyl groups
RB6383	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RB6384	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RB6389	COG4864	UPF0365 protein
RB6391	COG1295	ribonuclease BN
RB6391	COG1959	2 iron, 2 sulfur cluster binding
RB6394	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RB641	COG0784	Response regulator, receiver
RB641	COG2205	protein histidine kinase activity
RB6411	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RB6416	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RB6425	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RB6428	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RB6435	COG0736	holo-[acyl-carrier-protein] synthase activity
RB6436	COG0180	Tryptophanyl-tRNA synthetase
RB6443	COG0626	cystathionine gamma-synthase activity
RB6467	COG0588	phosphoglycerate mutase activity
RB6469	COG4555	ABC transporter
RB6470	COG1668	transmembrane transport
RB6472	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RB6482	COG0564	pseudouridine synthase activity
RB6484	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RB6485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RB6488	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RB6490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB6491	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RB6492	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RB6494	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RB6499	COG2962	Rard protein
RB6500	COG3321	synthase
RB6500	COG1028	Short-chain dehydrogenase reductase Sdr
RB6500	COG0604	alcohol dehydrogenase
RB6524	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RB6524	COG0037	tRNA processing
RB6530	COG3132	Protein of unknown function, DUF480
RB6533	COG0318	PFAM AMP-dependent synthetase and ligase
RB6538	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB6542	COG1609	Transcriptional regulator
RB6542	COG2207	Transcriptional regulator
RB6552	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RB6554	COG0482	sulfurtransferase activity
RB6563	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RB658	COG0628	permease
RB6588	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RB6599	COG3119	arylsulfatase activity
RB6603	COG0714	Associated with various cellular activities
RB6607	COG0237	dephospho-CoA kinase activity
RB6616	COG0151	Belongs to the GarS family
RB6624	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RB6643	COG1595	DNA-templated transcription, initiation
RB6644	COG0515	serine threonine protein kinase
RB6644	COG2815	serine threonine protein kinase
RB6654	COG0297	glycogen (starch) synthase activity
RB6670	COG0009	L-threonylcarbamoyladenylate synthase
RB6686	COG0745	RESPONSE REGULATOR receiver
RB6688	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RB6690	COG0191	fructose-bisphosphate aldolase activity
RB6725	COG0657	acetylesterase activity
RB6729	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RB6746	COG2226	methyltransferase
RB6751	COG0542	response to heat
RB6755	COG0318	PFAM AMP-dependent synthetase and ligase
RB6756	COG0189	ligase activity
RB6759	COG3252	Catalyzes the hydrolysis of methenyl-H(4)MPT( ) to 5- formyl-H(4)MPT
RB6765	COG3119	arylsulfatase activity
RB6770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RB678	COG4806	L-rhamnose isomerase
RB6780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RB6781	COG3119	arylsulfatase activity
RB6781	COG3408	Glycogen debranching enzyme
RB680	COG1917	Cupin 2, conserved barrel domain protein
RB680	COG2207	Transcriptional regulator
RB6808	COG0509	glycine decarboxylation via glycine cleavage system
RB6809	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RB681	COG0235	Class ii aldolase
RB6813	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RB6818	COG5002	protein histidine kinase activity
RB6821	COG0436	Aminotransferase
RB6822	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RB6825	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RB6828	COG0181	hydroxymethylbilane synthase activity
RB683	COG1012	belongs to the aldehyde dehydrogenase family
RB6831	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
RB6841	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RB6844	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RB6845	COG0489	protein tyrosine kinase activity
RB6860	COG0673	inositol 2-dehydrogenase activity
RB6873	COG3119	arylsulfatase activity
RB6881	COG4591	ABC-type transport system involved in lipoprotein release permease component
RB6883	COG1136	(ABC) transporter
RB6895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RB6920	COG4537	Required for transformation and DNA binding
RB6930	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RB6933	COG1013	pyruvate-flavodoxin oxidoreductase activity
RB6935	COG0674	pyruvate-flavodoxin oxidoreductase activity
RB6935	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RB695	COG3119	arylsulfatase activity
RB6956	COG3119	arylsulfatase activity
RB6959	COG2255	four-way junction helicase activity
RB6962	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RB6963	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RB6967	COG0628	permease
RB6973	COG0500	methyltransferase
RB6977	COG4284	Utp--glucose-1-phosphate uridylyltransferase
RB6982	COG1136	(ABC) transporter
RB6983	COG0577	efflux transmembrane transporter activity
RB6985	COG0673	inositol 2-dehydrogenase activity
RB6993	COG0175	sulfate reduction
RB6994	COG1959	2 iron, 2 sulfur cluster binding
RB700	COG3250	beta-galactosidase activity
RB7000	COG0322	excinuclease ABC activity
RB7004	COG1028	Short-chain dehydrogenase reductase Sdr
RB7008	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RB7010	COG0322	excinuclease ABC activity
RB7022	COG0268	Binds directly to 16S ribosomal RNA
RB7070	COG0202	RNA polymerase activity
RB708	COG3119	arylsulfatase activity
RB7081	COG1028	Short-chain dehydrogenase reductase Sdr
RB7087	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RB7088	COG1758	RNA polymerase activity
RB7090	COG0194	GDP metabolic process
RB7091	COG1561	YicC-like family, N-terminal region
RB7095	COG0149	triose-phosphate isomerase activity
RB7096	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
RB7098	COG1595	DNA-templated transcription, initiation
RB7099	COG2304	oxidoreductase activity
RB7112	COG0072	phenylalanine-tRNA ligase activity
RB7114	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RB7115	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RB7117	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RB7123	COG2201	protein-glutamate methylesterase activity
RB7130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RB7130	COG1918	ferrous iron import across plasma membrane
RB7134	COG1127	ABC transporter
RB7146	COG0297	glycogen (starch) synthase activity
RB7167	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RB7168	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RB7169	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RB7171	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RB7175	COG0315	cyclic pyranopterin monophosphate synthase activity
RB720	COG3119	arylsulfatase activity
RB7201	COG0322	excinuclease ABC activity
RB7206	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RB7210	COG0704	Plays a role in the regulation of phosphate uptake
RB7211	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RB7212	COG0573	inorganic phosphate transmembrane transporter activity
RB7215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RB7220	COG1966	Carbon starvation protein
RB7232	COG1136	(ABC) transporter
RB7232	COG0577	efflux transmembrane transporter activity
RB7237	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RB724	COG3119	arylsulfatase activity
RB7244	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RB7247	COG0174	glutamine synthetase
RB7259	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RB7260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RB7275	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RB7285	COG1560	Kdo2-lipid A biosynthetic process
RB7288	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RB7289	COG1116	anion transmembrane transporter activity
RB7292	COG1234	tRNA 3'-trailer cleavage
RB7297	COG4067	protein conserved in archaea
RB7297	COG0189	ligase activity
RB7299	COG0189	ligase activity
RB7299	COG0569	domain protein
RB7300	COG1663	tetraacyldisaccharide 4'-kinase activity
RB7314	COG1879	ABC-type sugar transport system periplasmic component
RB7359	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RB736	COG3408	Glycogen debranching enzyme
RB736	COG3119	arylsulfatase activity
RB7367	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB7368	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB7375	COG2195	Cleaves the N-terminal amino acid of tripeptides
RB7385	COG1028	Short-chain dehydrogenase reductase Sdr
RB7388	COG4974	Belongs to the 'phage' integrase family
RB7389	COG0517	IMP dehydrogenase activity
RB7399	COG4974	Belongs to the 'phage' integrase family
RB7408	COG0793	Belongs to the peptidase S41A family
RB7410	COG5002	protein histidine kinase activity
RB7424	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RB7425	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RB7428	COG2363	Small membrane protein
RB7429	COG0540	Belongs to the ATCase OTCase family
RB7430	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RB7431	COG0594	ribonuclease P activity
RB7435	COG1968	undecaprenyl-diphosphatase activity
RB7437	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RB7443	COG1558	bacterial-type flagellum-dependent cell motility
RB7444	COG1677	Flagellar hook-basal body complex protein FliE
RB7453	COG1104	cysteine desulfurase activity
RB7465	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RB7468	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RB7474	COG2198	Histidine kinase
RB7474	COG0784	Response regulator, receiver
RB7474	COG2205	protein histidine kinase activity
RB7481	COG3119	arylsulfatase activity
RB7482	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
RB7500	COG0714	Associated with various cellular activities
RB7510	COG3876	Protein conserved in bacteria
RB7514	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
RB7515	COG2971	BadF BadG BcrA BcrD
RB7546	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RB7560	COG3119	arylsulfatase activity
RB7564	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RB7569	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RB7572	COG0205	6-phosphofructokinase activity
RB7579	COG2204	response regulator
RB7580	COG0351	phosphomethylpyrimidine kinase
RB7583	COG0095	Lipoate-protein ligase
RB7584	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RB7585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RB7586	COG0509	glycine decarboxylation via glycine cleavage system
RB7587	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RB7590	COG0612	Peptidase, M16
RB7598	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RB7600	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RB7616	COG1556	Lactate utilization protein
RB7618	COG1139	Iron-sulfur cluster binding protein
RB7623	COG0114	fumarate hydratase activity
RB7625	COG2610	gluconate transmembrane transporter activity
RB7627	COG1418	mRNA catabolic process
RB7629	COG0037	tRNA processing
RB763	COG3119	arylsulfatase activity
RB7633	COG4555	ABC transporter
RB7634	COG1668	transmembrane transport
RB7643	COG1215	transferase activity, transferring glycosyl groups
RB7652	COG0039	L-malate dehydrogenase activity
RB7661	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RB7662	COG0131	Imidazoleglycerol-phosphate dehydratase
RB772	COG3119	arylsulfatase activity
RB773	COG3119	arylsulfatase activity
RB7769	COG3119	arylsulfatase activity
RB7773	COG0445	tRNA wobble uridine modification
RB7798	COG0515	serine threonine protein kinase
RB7798	COG2815	serine threonine protein kinase
RB7803	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RB7807	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RB7818	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RB7820	COG0049	tRNA binding
RB7821	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RB7823	COG0436	Aminotransferase
RB7829	COG0051	transcription antitermination factor activity, RNA binding
RB783	COG0798	PFAM Bile acid sodium symporter
RB7833	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RB7834	COG0088	Forms part of the polypeptide exit tunnel
RB7836	COG0089	rRNA binding
RB7837	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RB7838	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RB7839	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RB7840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RB7841	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RB7846	COG0255	Belongs to the universal ribosomal protein uL29 family
RB7849	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RB7850	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RB7851	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RB7852	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RB7854	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RB7855	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RB7856	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RB7857	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RB7859	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RB7863	COG0200	Binds to the 23S rRNA
RB7867	COG0563	adenylate kinase activity
RB7875	COG3119	arylsulfatase activity
RB7883	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RB7885	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RB7894	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RB7899	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RB7903	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RB7906	COG0742	ribosomal rna small subunit methyltransferase
RB7911	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB7941	COG0529	Catalyzes the synthesis of activated sulfate
RB7941	COG2895	sulfate adenylyltransferase (ATP) activity
RB7943	COG0175	sulfate reduction
RB7945	COG0357	Ribosomal RNA small subunit methyltransferase G
RB7957	COG1754	DNA topoisomerase type I activity
RB7957	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RB7960	COG3869	Catalyzes the specific phosphorylation of arginine residues in
RB7985	COG1446	asparaginase
RB7995	COG3119	arylsulfatase activity
RB8	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RB8026	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RB8028	COG0515	serine threonine protein kinase
RB8028	COG2815	serine threonine protein kinase
RB8029	COG1028	Short-chain dehydrogenase reductase Sdr
RB8030	COG3119	arylsulfatase activity
RB8031	COG2706	6-phosphogluconolactonase activity
RB8035	COG0569	domain protein
RB8049	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RB8060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RB8062	COG1199	ATP-dependent helicase activity
RB807	COG5433	transposase activity
RB8073	COG3940	Belongs to the glycosyl hydrolase 43 family
RB8076	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RB8078	COG3119	arylsulfatase activity
RB8080	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RB8082	COG3046	protein related to deoxyribodipyrimidine photolyase
RB8102	COG4968	Prepilin-type N-terminal cleavage methylation domain
RB8116	COG1725	Transcriptional regulator
RB8125	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RB8140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RB8149	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RB8152	COG1959	2 iron, 2 sulfur cluster binding
RB8161	COG0708	Exodeoxyribonuclease III
RB8173	COG0714	Associated with various cellular activities
RB818	COG3344	reverse transcriptase
RB8205	COG2094	Belongs to the DNA glycosylase MPG family
RB8208	COG0402	S-adenosylhomocysteine deaminase activity
RB8219	COG0436	Aminotransferase
RB8222	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RB8222	COG2813	Specifically methylates the guanine in position
RB8233	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RB8238	COG0450	alkyl hydroperoxide reductase
RB8240	COG0706	membrane insertase activity
RB8240	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RB8253	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RB8254	COG0531	amino acid
RB8260	COG1872	DUF167
RB8262	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RB8262	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
RB8262	COG0506	proline dehydrogenase activity
RB8265	COG0824	Thioesterase
RB8268	COG0275	rRNA processing
RB8274	COG3852	Histidine kinase
RB8284	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RB8286	COG0196	riboflavin kinase activity
RB8287	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RB8290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RB8291	COG1691	(AIR) carboxylase
RB8293	COG0137	argininosuccinate synthase activity
RB8300	COG1490	D-aminoacyl-tRNA deacylase activity
RB8310	COG0825	malonyl-CoA metabolic process
RB8311	COG0515	serine threonine protein kinase
RB8311	COG2815	serine threonine protein kinase
RB8316	COG1191	sigma factor activity
RB8320	COG1419	protein localization to endoplasmic reticulum
RB8323	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RB8326	COG0515	serine threonine protein kinase
RB8326	COG2815	serine threonine protein kinase
RB8328	COG3481	metal-dependent phosphohydrolase, HD sub domain
RB8329	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RB8359	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RB8363	COG2195	Cleaves the N-terminal amino acid of tripeptides
RB8368	COG1054	Belongs to the UPF0176 family
RB8374	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RB8374	COG0519	Catalyzes the synthesis of GMP from XMP
RB8383	COG0058	SHG alpha-glucan phosphorylase activity
RB8397	COG0556	nucleotide-excision repair
RB8399	COG1435	thymidine kinase activity
RB8402	COG0557	exoribonuclease II activity
RB8404	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RB8418	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RB8423	COG3119	arylsulfatase activity
RB8455	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RB8459	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RB8476	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RB8482	COG0688	phosphatidylethanolamine metabolic process
RB8492	COG1595	DNA-templated transcription, initiation
RB8494	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
RB8515	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RB8522	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RB8531	COG0805	protein transport
RB8533	COG0693	protein deglycase activity
RB8540	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
RB8540	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RB8541	COG1363	Peptidase, m42
RB8542	COG0563	adenylate kinase activity
RB8543	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RB8548	COG0511	ligase activity, forming carbon-carbon bonds
RB8550	COG0439	Biotin carboxylase
RB8555	COG0515	serine threonine protein kinase
RB8555	COG2815	serine threonine protein kinase
RB8562	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RB8584	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RB8588	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RB8595	COG1530	ribonuclease E activity
RB8596	COG3119	arylsulfatase activity
RB8597	COG3119	arylsulfatase activity
RB8598	COG0243	molybdopterin cofactor binding
RB8604	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RB861	COG0811	peptide transport
RB8613	COG0047	phosphoribosylformylglycinamidine synthase activity
RB8629	COG4636	protein conserved in cyanobacteria
RB8635	COG1408	metallophosphoesterase
RB8649	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RB8680	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RB8686	COG4948	Mandelate Racemase Muconate Lactonizing
RB8693	COG1131	(ABC) transporter
RB8695	COG1725	Transcriptional regulator
RB8701	COG1595	DNA-templated transcription, initiation
RB8707	COG1459	type II secretion system
RB8711	COG1459	type II secretion system
RB8725	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RB8726	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
RB8726	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RB8728	COG1028	Short-chain dehydrogenase reductase Sdr
RB8747	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RB8748	COG0167	dihydroorotate dehydrogenase activity
RB8763	COG2304	oxidoreductase activity
RB8768	COG0714	Associated with various cellular activities
RB8777	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RB8779	COG1760	l-serine dehydratase
RB8788	COG1069	ribulokinase activity
RB8792	COG0823	Involved in the tonB-independent uptake of proteins
RB8797	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RB8798	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RB8799	COG0673	inositol 2-dehydrogenase activity
RB8812	COG1040	competence protein
RB8816	COG1595	DNA-templated transcription, initiation
RB8820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
RB8834	COG1230	cation diffusion facilitator family transporter
RB8840	COG1254	Belongs to the acylphosphatase family
RB8853	COG3424	synthase
RB8859	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RB8861	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RB8870	COG0489	protein tyrosine kinase activity
RB8872	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
RB8873	COG2205	protein histidine kinase activity
RB8873	COG0784	Response regulator, receiver
RB8889	COG3540	Alkaline phosphatase
RB8892	COG2010	Cytochrome c
RB8905	COG0463	Glycosyl transferase, family 2
RB8913	COG0135	phosphoribosylanthranilate isomerase activity
RB8919	COG0495	leucyl-tRNA aminoacylation
RB8921	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RB8924	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
RB8926	COG0527	aspartate kinase activity
RB8929	COG0515	serine threonine protein kinase
RB8929	COG2815	serine threonine protein kinase
RB8935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RB8937	COG0446	pyridine nucleotide-disulphide oxidoreductase
RB8966	COG0459	protein refolding
RB8969	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RB8970	COG0459	protein refolding
RB8972	COG0484	heat shock protein binding
RB8974	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RB8978	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RB8979	COG1760	l-serine dehydratase
RB8983	COG0714	Associated with various cellular activities
RB8985	COG2852	Protein conserved in bacteria
RB9012	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RB9019	COG0515	serine threonine protein kinase
RB9019	COG2815	serine threonine protein kinase
RB9026	COG0673	inositol 2-dehydrogenase activity
RB9029	COG3590	peptidase
RB9076	COG0488	(ABC) transporter
RB9083	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RB9084	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RB9089	COG0363	glucosamine-6-phosphate deaminase activity
RB9090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RB9091	COG3119	arylsulfatase activity
RB9103	COG0542	response to heat
RB9105	COG0443	Heat shock 70 kDa protein
RB9107	COG1605	Chorismate mutase
RB9107	COG0077	Prephenate dehydratase
RB9108	COG0714	Associated with various cellular activities
RB9113	COG0693	protein deglycase activity
RB9115	COG0792	nuclease activity
RB9116	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RB9119	COG2239	Acts as a magnesium transporter
RB9132	COG0673	inositol 2-dehydrogenase activity
RB9133	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RB9134	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RB9141	COG2813	Specifically methylates the guanine in position
RB9168	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RB9169	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
RB918	COG4974	Belongs to the 'phage' integrase family
RB9192	COG3119	arylsulfatase activity
RB9210	COG1104	cysteine desulfurase activity
RB9215	COG0508	dehydrogenase complex catalyzes the overall conversion of
RB9218	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RB9237	COG1216	Glycosyl transferase, family 2
RB925	COG0517	IMP dehydrogenase activity
RB9255	COG0445	tRNA wobble uridine modification
RB9268	COG1582	Flagellar protein (FlbD)
RB927	COG4974	Belongs to the 'phage' integrase family
RB9271	COG1360	Flagellar Motor Protein
RB9275	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RB9275	COG1776	CheC inhibitor of MCP methylation
RB9278	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
RB9280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RB9280	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
RB9283	COG1562	ergosterol biosynthetic process
RB9284	COG1562	ergosterol biosynthetic process
RB9288	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RB9304	COG0254	rRNA binding
RB9305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RB9306	COG2890	protein-(glutamine-N5) methyltransferase activity
RB934	COG0517	IMP dehydrogenase activity
RB9344	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RB9364	COG4650	regulator
RB9367	COG1082	Xylose isomerase domain protein TIM barrel
RB9367	COG3185	4-Hydroxyphenylpyruvate dioxygenase
RB9372	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RB9374	COG0514	ATP-dependent DNA helicase (RecQ)
RB9384	COG1172	Belongs to the binding-protein-dependent transport system permease family
RB9385	COG1129	ABC transporter
RB9395	COG2409	Drug exporters of the RND superfamily
RB9401	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RB9402	COG0612	Peptidase, M16
RB9404	COG0612	Peptidase, M16
RB9418	COG4251	negative regulation of phosphorylation
RB9420	COG1132	(ABC) transporter
RB9427	COG2304	oxidoreductase activity
RB9428	COG5002	protein histidine kinase activity
RB9431	COG0745	RESPONSE REGULATOR receiver
RB9435	COG0515	serine threonine protein kinase
RB945	COG1620	l-lactate permease
RB9470	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RB9477	COG1131	(ABC) transporter
RB9488	COG2855	membrane
RB9498	COG3119	arylsulfatase activity
RB9499	COG0714	Associated with various cellular activities
RB9526	COG1566	PFAM secretion protein HlyD family protein
RB9530	COG3119	arylsulfatase activity
RB9533	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RB9543	COG0628	permease
RB9549	COG3119	arylsulfatase activity
RB956	COG0517	IMP dehydrogenase activity
RB957	COG4974	Belongs to the 'phage' integrase family
RB9570	COG3604	Transcriptional regulator
RB9581	COG1733	regulation of RNA biosynthetic process
RB9584	COG0604	alcohol dehydrogenase
RB9584	COG1028	Short-chain dehydrogenase reductase Sdr
RB9584	COG3321	synthase
RB9585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RB9592	COG3541	Predicted nucleotidyltransferase
RB9611	COG0577	efflux transmembrane transporter activity
RB9611	COG1136	(ABC) transporter
RB962	COG4974	Belongs to the 'phage' integrase family
RB9623	COG1215	transferase activity, transferring glycosyl groups
RB9637	COG1216	Glycosyl transferase, family 2
RB9643	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RB9650	COG3119	arylsulfatase activity
RB9654	COG0280	phosphate acetyltransferase
RB9654	COG0857	belongs to the CobB CobQ family
RB9655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RB9657	COG0667	Aldo Keto reductase
RB9658	COG4628	conserved protein (DUF2132)
RB9659	COG3384	dioxygenase
RB9674	COG2936	dipeptidyl-peptidase activity
RB973	COG3119	arylsulfatase activity
RB974	COG1671	Belongs to the UPF0178 family
RB9745	COG2815	serine threonine protein kinase
RB9745	COG0515	serine threonine protein kinase
RB9748	COG0167	dihydroorotate dehydrogenase activity
RB9755	COG3119	arylsulfatase activity
RB9766	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RB977	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RB9790	COG0537	adenosine 5'-monophosphoramidase activity
RB9791	COG2003	Belongs to the UPF0758 family
RB9794	COG0347	Belongs to the P(II) protein family
RB9795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RB9808	COG0606	chelatase, subunit chli
RB9821	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
RB9823	COG0517	IMP dehydrogenase activity
RB9823	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RB9828	COG1914	H( )-stimulated, divalent metal cation uptake system
RB9832	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RB9834	COG1229	Formylmethanofuran dehydrogenase subunit A
RB9835	COG2037	Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)
RB9840	COG2333	competence protein COMEC
RB9840	COG0658	competence protein
RB9848	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
RB9854	COG0515	serine threonine protein kinase
RB9854	COG2815	serine threonine protein kinase
RB9857	COG1410	methionine synthase
RB9857	COG0646	methionine synthase
RB9860	COG3618	amidohydrolase
RB9869	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RB9871	COG0440	acetolactate synthase activity
RB9874	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RB9876	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RB9892	COG1271	oxidase subunit
RB9894	COG1294	oxidase, subunit
RB9916	COG0359	binds to the 23S rRNA
RB9917	COG0629	single-stranded DNA binding
RB9920	COG0360	Binds together with S18 to 16S ribosomal RNA
RB9922	COG0193	aminoacyl-tRNA hydrolase activity
RB9923	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RB9927	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RB993	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RB9942	COG0357	Ribosomal RNA small subunit methyltransferase G
RB9943	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RB9952	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RB9953	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RB9971	COG0673	inositol 2-dehydrogenase activity
RB9983	COG1482	cell wall glycoprotein biosynthetic process
RB9992	COG0719	Fe-S assembly protein
RB9995	COG0719	Fe-S assembly protein
RB9998	COG0396	ATPase activity