locus-tag	class	description
RPE_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RPE_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RPE_RS00030	COG3920	Histidine kinase
RPE_RS00040	COG1522	sequence-specific DNA binding
RPE_RS00055	COG2217	Heavy metal translocating P-type atpase
RPE_RS00070	COG2010	Cytochrome c
RPE_RS00085	COG3278	Belongs to the heme-copper respiratory oxidase family
RPE_RS00090	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPE_RS00110	COG4221	oxidoreductase activity
RPE_RS00115	COG0405	Gamma-glutamyltransferase
RPE_RS00125	COG0138	bifunctional purine biosynthesis protein purh
RPE_RS00140	COG5508	conserved small protein
RPE_RS00160	COG1785	Belongs to the alkaline phosphatase family
RPE_RS00165	COG0137	argininosuccinate synthase activity
RPE_RS00170	COG0671	phosphoesterase, PA-phosphatase related
RPE_RS00185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RPE_RS00205	COG1247	-acetyltransferase
RPE_RS00210	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RPE_RS00215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPE_RS00220	COG0840	transmembrane signaling receptor activity
RPE_RS00225	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RPE_RS00230	COG1872	DUF167
RPE_RS00265	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS00285	COG2814	Major facilitator Superfamily
RPE_RS00325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RPE_RS00330	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RPE_RS00345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPE_RS00375	COG1881	PFAM PEBP family protein
RPE_RS00395	COG2192	nodulation
RPE_RS00430	COG2308	Evidence 4 Homologs of previously reported genes of
RPE_RS00430	COG2307	Protein conserved in bacteria
RPE_RS00445	COG5001	Diguanylate cyclase
RPE_RS00450	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
RPE_RS00460	COG3263	regulation of cellular component size
RPE_RS00470	COG0024	Methionine aminopeptidase
RPE_RS00480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RPE_RS00500	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPE_RS00510	COG2003	Belongs to the UPF0758 family
RPE_RS00520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPE_RS00550	COG0069	glutamate synthase activity
RPE_RS00555	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPE_RS00560	COG0285	dihydrofolate synthase activity
RPE_RS00565	COG2130	NADP-dependent
RPE_RS00580	COG3753	Protein conserved in bacteria
RPE_RS00600	COG1960	acyl-CoA dehydrogenase activity
RPE_RS00605	COG1024	Enoyl-CoA hydratase
RPE_RS00650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RPE_RS00685	COG0586	Pfam SNARE associated Golgi protein
RPE_RS00700	COG3034	peptidoglycan biosynthetic process
RPE_RS00705	COG0825	malonyl-CoA metabolic process
RPE_RS00710	COG4974	Belongs to the 'phage' integrase family
RPE_RS00720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPE_RS00725	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RPE_RS00730	COG1253	flavin adenine dinucleotide binding
RPE_RS00735	COG0653	protein targeting
RPE_RS00740	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RPE_RS00745	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RPE_RS00765	COG1040	competence protein
RPE_RS00770	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RPE_RS00775	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RPE_RS00790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RPE_RS00795	COG0527	aspartate kinase activity
RPE_RS00805	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RPE_RS00810	COG2890	protein-(glutamine-N5) methyltransferase activity
RPE_RS00820	COG2226	methyltransferase
RPE_RS00825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPE_RS00835	COG0697	spore germination
RPE_RS00850	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
RPE_RS00860	COG5001	Diguanylate cyclase
RPE_RS00860	COG3300	MHYT domain
RPE_RS00875	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RPE_RS00885	COG0142	geranyltranstransferase activity
RPE_RS00905	COG5001	Diguanylate cyclase
RPE_RS00925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RPE_RS00945	COG0735	belongs to the Fur family
RPE_RS00955	COG1566	PFAM secretion protein HlyD family protein
RPE_RS00970	COG1185	polyribonucleotide nucleotidyltransferase activity
RPE_RS00975	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RPE_RS00980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RPE_RS00985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RPE_RS00990	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RPE_RS01005	COG0779	Required for maturation of 30S ribosomal subunits
RPE_RS01010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RPE_RS01015	COG1396	sequence-specific DNA binding
RPE_RS01020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RPE_RS01025	COG1253	flavin adenine dinucleotide binding
RPE_RS01030	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RPE_RS01035	COG1702	phosphate starvation-inducible protein PhoH
RPE_RS01040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPE_RS01045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPE_RS01070	COG0488	(ABC) transporter
RPE_RS01090	COG0180	Tryptophanyl-tRNA synthetase
RPE_RS01095	COG0728	peptidoglycan biosynthetic process
RPE_RS01100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPE_RS01125	COG1971	Probably functions as a manganese efflux pump
RPE_RS01130	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RPE_RS01150	COG1131	(ABC) transporter
RPE_RS01160	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RPE_RS01175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RPE_RS01225	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RPE_RS01240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RPE_RS01250	COG0183	Belongs to the thiolase family
RPE_RS01265	COG2272	Belongs to the type-B carboxylesterase lipase family
RPE_RS01270	COG0583	DNA-binding transcription factor activity
RPE_RS01275	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RPE_RS01280	COG0625	glutathione transferase activity
RPE_RS01285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RPE_RS01295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPE_RS01300	COG0735	belongs to the Fur family
RPE_RS01310	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RPE_RS01340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RPE_RS01345	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RPE_RS01350	COG0799	negative regulation of ribosome biogenesis
RPE_RS01355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RPE_RS01365	COG0793	Belongs to the peptidase S41A family
RPE_RS01375	COG0494	nUDIX hydrolase
RPE_RS01390	COG1051	belongs to the nudix hydrolase family
RPE_RS01395	COG0113	porphobilinogen synthase activity
RPE_RS01405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RPE_RS01410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RPE_RS01415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RPE_RS01420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RPE_RS01425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RPE_RS01430	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RPE_RS01440	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
RPE_RS01455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPE_RS01465	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS01485	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPE_RS01495	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RPE_RS01500	COG0045	succinate-CoA ligase (ADP-forming) activity
RPE_RS01505	COG0039	L-malate dehydrogenase activity
RPE_RS01510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RPE_RS01515	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
RPE_RS01520	COG2755	lipolytic protein G-D-S-L family
RPE_RS01525	COG4181	ATPase activity
RPE_RS01530	COG1136	(ABC) transporter
RPE_RS01530	COG0577	efflux transmembrane transporter activity
RPE_RS01535	COG0670	Belongs to the BI1 family
RPE_RS01555	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
RPE_RS01560	COG4133	protoheme IX ABC transporter activity
RPE_RS01565	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPE_RS01570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RPE_RS01580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPE_RS01590	COG2917	probably involved in intracellular septation
RPE_RS01595	COG0552	protein localization to endoplasmic reticulum
RPE_RS01600	COG0564	pseudouridine synthase activity
RPE_RS01605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPE_RS01610	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RPE_RS01620	COG2968	Membrane
RPE_RS01640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RPE_RS01645	COG0228	four-way junction DNA binding
RPE_RS01650	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RPE_RS01655	COG0336	Belongs to the RNA methyltransferase TrmD family
RPE_RS01660	COG0335	large ribosomal subunit rRNA binding
RPE_RS01665	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RPE_RS01675	COG0175	sulfate reduction
RPE_RS01700	COG0066	3-isopropylmalate dehydratase activity
RPE_RS01710	COG0288	reversible hydration of carbon dioxide
RPE_RS01715	COG0588	phosphoglycerate mutase activity
RPE_RS01720	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RPE_RS01730	COG0284	orotidine-5'-phosphate decarboxylase activity
RPE_RS01740	COG3963	phosphatidate phosphatase activity
RPE_RS01745	COG0484	heat shock protein binding
RPE_RS01750	COG0443	Heat shock 70 kDa protein
RPE_RS01760	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RPE_RS01765	COG1420	regulation of RNA biosynthetic process
RPE_RS01770	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RPE_RS01775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RPE_RS01780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPE_RS01790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RPE_RS01795	COG0792	nuclease activity
RPE_RS01800	COG0189	ligase activity
RPE_RS01815	COG2205	protein histidine kinase activity
RPE_RS01815	COG5002	protein histidine kinase activity
RPE_RS01815	COG0784	Response regulator, receiver
RPE_RS01825	COG1072	(Pantothenic acid kinase))
RPE_RS01830	COG0140	phosphoribosyl-ATP diphosphatase activity
RPE_RS01835	COG0107	imidazoleglycerol-phosphate synthase activity
RPE_RS01840	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RPE_RS01845	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RPE_RS01855	COG0131	Imidazoleglycerol-phosphate dehydratase
RPE_RS01860	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RPE_RS01865	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RPE_RS01875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
RPE_RS01885	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RPE_RS01890	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RPE_RS01895	COG0237	dephospho-CoA kinase activity
RPE_RS01900	COG0424	maF-like protein
RPE_RS01905	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
RPE_RS01910	COG1981	membrane
RPE_RS01915	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RPE_RS01920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RPE_RS01925	COG0445	tRNA wobble uridine modification
RPE_RS01930	COG0357	Ribosomal RNA small subunit methyltransferase G
RPE_RS01955	COG0495	leucyl-tRNA aminoacylation
RPE_RS01960	COG2203	Gaf domain
RPE_RS01960	COG3706	GGDEF domain
RPE_RS01960	COG5001	Diguanylate cyclase
RPE_RS01960	COG4251	negative regulation of phosphorylation
RPE_RS01965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RPE_RS01975	COG0745	RESPONSE REGULATOR receiver
RPE_RS01990	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RPE_RS01995	COG1674	ftsk spoiiie
RPE_RS02000	COG0436	Aminotransferase
RPE_RS02015	COG0004	ammonium transporteR
RPE_RS02020	COG0347	Belongs to the P(II) protein family
RPE_RS02025	COG0004	ammonium transporteR
RPE_RS02030	COG0347	Belongs to the P(II) protein family
RPE_RS02035	COG1946	Acyl-CoA thioesterase
RPE_RS02040	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPE_RS02045	COG2835	tetraacyldisaccharide 4'-kinase activity
RPE_RS02080	COG0443	Heat shock 70 kDa protein
RPE_RS02085	COG2183	response to ionizing radiation
RPE_RS02110	COG3864	Putative metallopeptidase domain
RPE_RS02120	COG1850	ribulose-bisphosphate carboxylase activity
RPE_RS02130	COG3012	SEC-C Motif Domain Protein
RPE_RS02135	COG0488	(ABC) transporter
RPE_RS02150	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
RPE_RS02155	COG1137	ATPase activity
RPE_RS02160	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RPE_RS02165	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RPE_RS02170	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPE_RS02185	COG0071	Belongs to the small heat shock protein (HSP20) family
RPE_RS02190	COG3842	ATPase activity
RPE_RS02195	COG0395	ABC-type sugar transport system, permease component
RPE_RS02200	COG1175	transmembrane transport
RPE_RS02205	COG2852	Protein conserved in bacteria
RPE_RS02230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RPE_RS02240	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RPE_RS02255	COG0539	negative regulation of cytoplasmic translation
RPE_RS02260	COG0616	signal peptide processing
RPE_RS02265	COG0776	regulation of translation
RPE_RS02275	COG0135	phosphoribosylanthranilate isomerase activity
RPE_RS02280	COG0133	tryptophan synthase activity
RPE_RS02285	COG0159	tryptophan synthase activity
RPE_RS02290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RPE_RS02300	COG2813	Specifically methylates the guanine in position
RPE_RS02310	COG1074	ATP-dependent DNA helicase activity
RPE_RS02320	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPE_RS02330	COG3178	'Phosphotransferase
RPE_RS02335	COG2205	protein histidine kinase activity
RPE_RS02345	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RPE_RS02355	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPE_RS02360	COG2226	methyltransferase
RPE_RS02365	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RPE_RS02370	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS02380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RPE_RS02385	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RPE_RS02390	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
RPE_RS02395	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPE_RS02400	COG0477	Major facilitator Superfamily
RPE_RS02405	COG0473	3-isopropylmalate dehydrogenase activity
RPE_RS02410	COG1943	Transposase
RPE_RS02425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RPE_RS02430	COG2862	Uncharacterized protein family, UPF0114
RPE_RS02435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPE_RS02445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RPE_RS02470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RPE_RS02470	COG0072	phenylalanine-tRNA ligase activity
RPE_RS02490	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RPE_RS02495	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RPE_RS02510	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RPE_RS02520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RPE_RS02530	COG1968	undecaprenyl-diphosphatase activity
RPE_RS02550	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS02565	COG2009	succinate dehydrogenase
RPE_RS02605	COG3788	relative of glutathione S-transferase, MAPEG superfamily
RPE_RS02645	COG4206	TonB-dependent receptor
RPE_RS02650	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPE_RS02655	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RPE_RS02670	COG2814	Major facilitator Superfamily
RPE_RS02675	COG1960	acyl-CoA dehydrogenase activity
RPE_RS02680	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS02685	COG1960	acyl-CoA dehydrogenase activity
RPE_RS02690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPE_RS02700	COG1294	oxidase, subunit
RPE_RS02705	COG1271	oxidase subunit
RPE_RS02710	COG1595	DNA-templated transcription, initiation
RPE_RS02720	COG0784	Response regulator, receiver
RPE_RS02720	COG3437	response regulator, receiver
RPE_RS02725	COG4191	Histidine kinase
RPE_RS02725	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPE_RS02730	COG1653	transport
RPE_RS02745	COG1741	Belongs to the pirin family
RPE_RS02750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPE_RS02755	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RPE_RS02760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RPE_RS02770	COG2116	formate transmembrane transporter activity
RPE_RS02780	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RPE_RS02785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RPE_RS02810	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
RPE_RS02815	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RPE_RS02890	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RPE_RS02895	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS02905	COG0367	asparagine synthase
RPE_RS02955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPE_RS02965	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPE_RS02990	COG1959	2 iron, 2 sulfur cluster binding
RPE_RS03000	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPE_RS03005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPE_RS03005	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPE_RS03010	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPE_RS03040	COG0604	alcohol dehydrogenase
RPE_RS03045	COG1846	Transcriptional regulator
RPE_RS03055	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
RPE_RS03065	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS03090	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS03095	COG0714	Associated with various cellular activities
RPE_RS03100	COG3256	nitric oxide reductase
RPE_RS03115	COG1845	cytochrome c oxidase, subunit III
RPE_RS03145	COG2197	response regulator
RPE_RS03150	COG4251	negative regulation of phosphorylation
RPE_RS03155	COG4251	negative regulation of phosphorylation
RPE_RS03160	COG0784	Response regulator, receiver
RPE_RS03170	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RPE_RS03175	COG0516	GMP reductase activity
RPE_RS03185	COG1032	radical SAM domain protein
RPE_RS03210	COG3852	Histidine kinase
RPE_RS03215	COG0594	ribonuclease P activity
RPE_RS03220	COG0706	membrane insertase activity
RPE_RS03225	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RPE_RS03235	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RPE_RS03255	COG2171	N-acyltransferase activity
RPE_RS03265	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RPE_RS03270	COG0101	tRNA pseudouridine synthase activity
RPE_RS03275	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RPE_RS03280	COG0242	peptide deformylase activity
RPE_RS03285	COG1322	Protein conserved in bacteria
RPE_RS03290	COG0357	Ribosomal RNA small subunit methyltransferase G
RPE_RS03320	COG1132	(ABC) transporter
RPE_RS03325	COG0254	rRNA binding
RPE_RS03360	COG1960	acyl-CoA dehydrogenase activity
RPE_RS03365	COG0183	Belongs to the thiolase family
RPE_RS03370	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPE_RS03370	COG1024	Enoyl-CoA hydratase
RPE_RS03375	COG0625	glutathione transferase activity
RPE_RS03415	COG0070	glutamate synthase
RPE_RS03415	COG0069	glutamate synthase activity
RPE_RS03415	COG0067	glutamate synthase
RPE_RS03425	COG0071	Belongs to the small heat shock protein (HSP20) family
RPE_RS03435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RPE_RS03440	COG5001	Diguanylate cyclase
RPE_RS03440	COG4251	negative regulation of phosphorylation
RPE_RS03440	COG3706	GGDEF domain
RPE_RS03440	COG2203	Gaf domain
RPE_RS03480	COG2223	nitrite transmembrane transporter activity
RPE_RS03490	COG2184	nucleotidyltransferase activity
RPE_RS03500	COG2951	lytic endotransglycosylase activity
RPE_RS03505	COG1280	lysine exporter protein (LysE YggA)
RPE_RS03525	COG0483	inositol monophosphate 1-phosphatase activity
RPE_RS03550	COG0655	NAD(P)H dehydrogenase (quinone) activity
RPE_RS03555	COG1741	Belongs to the pirin family
RPE_RS03560	COG0583	DNA-binding transcription factor activity
RPE_RS03570	COG1678	Uncharacterized ACR, COG1678
RPE_RS03580	COG0730	response to heat
RPE_RS03590	COG3338	carbonate dehydratase activity
RPE_RS03605	COG0167	dihydroorotate dehydrogenase activity
RPE_RS03610	COG1234	tRNA 3'-trailer cleavage
RPE_RS03615	COG0534	Mate efflux family protein
RPE_RS03635	COG2226	methyltransferase
RPE_RS03655	COG1201	RNA secondary structure unwinding
RPE_RS03665	COG0583	DNA-binding transcription factor activity
RPE_RS03670	COG0697	spore germination
RPE_RS03700	COG1999	signal sequence binding
RPE_RS03725	COG0583	DNA-binding transcription factor activity
RPE_RS03735	COG2159	amidohydrolase
RPE_RS03775	COG0140	phosphoribosyl-ATP diphosphatase activity
RPE_RS03815	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RPE_RS03835	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPE_RS03835	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPE_RS03835	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPE_RS03835	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RPE_RS03840	COG0493	'glutamate synthase
RPE_RS03840	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPE_RS03855	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
RPE_RS03860	COG2072	flavoprotein involved in K transport
RPE_RS03910	COG1749	Flagellar hook protein flgE
RPE_RS03930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RPE_RS03940	COG1595	DNA-templated transcription, initiation
RPE_RS03965	COG1380	Effector of murein hydrolase LrgA
RPE_RS03975	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RPE_RS03975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
RPE_RS03990	COG0628	permease
RPE_RS03995	COG3806	Anti-sigma factor
RPE_RS04000	COG1595	DNA-templated transcription, initiation
RPE_RS04005	COG0302	gtp cyclohydrolase
RPE_RS04010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RPE_RS04025	COG0297	glycogen (starch) synthase activity
RPE_RS04030	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RPE_RS04035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
RPE_RS04035	COG0517	IMP dehydrogenase activity
RPE_RS04035	COG0617	tRNA 3'-terminal CCA addition
RPE_RS04050	COG0438	transferase activity, transferring glycosyl groups
RPE_RS04060	COG0438	transferase activity, transferring glycosyl groups
RPE_RS04070	COG0297	glycogen (starch) synthase activity
RPE_RS04080	COG2244	polysaccharide biosynthetic process
RPE_RS04110	COG0564	pseudouridine synthase activity
RPE_RS04115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPE_RS04120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RPE_RS04130	COG0745	RESPONSE REGULATOR receiver
RPE_RS04135	COG0642	Histidine kinase
RPE_RS04140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RPE_RS04145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
RPE_RS04145	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPE_RS04150	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
RPE_RS04160	COG0481	GTPase activity
RPE_RS04195	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RPE_RS04215	COG0519	Catalyzes the synthesis of GMP from XMP
RPE_RS04240	COG0535	radical SAM domain protein
RPE_RS04245	COG0535	radical SAM domain protein
RPE_RS04250	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RPE_RS04330	COG0459	protein refolding
RPE_RS04335	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPE_RS04355	COG1388	LysM domain
RPE_RS04355	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS04370	COG3416	Protein conserved in bacteria
RPE_RS04380	COG0463	Glycosyl transferase, family 2
RPE_RS04385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RPE_RS04390	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RPE_RS04405	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RPE_RS04420	COG0312	modulator of DNA gyrase
RPE_RS04425	COG0483	inositol monophosphate 1-phosphatase activity
RPE_RS04435	COG1519	Transferase
RPE_RS04440	COG1663	tetraacyldisaccharide 4'-kinase activity
RPE_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS04505	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RPE_RS04515	COG0501	Belongs to the peptidase M48B family
RPE_RS04520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RPE_RS04540	COG2943	transferase activity, transferring hexosyl groups
RPE_RS04545	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RPE_RS04580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPE_RS04595	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RPE_RS04600	COG0179	Fumarylacetoacetate (FAA) hydrolase
RPE_RS04605	COG0124	histidyl-tRNA synthetase
RPE_RS04610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RPE_RS04635	COG0745	RESPONSE REGULATOR receiver
RPE_RS04640	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RPE_RS04645	COG1278	Cold shock
RPE_RS04655	COG0322	excinuclease ABC activity
RPE_RS04660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RPE_RS04670	COG0314	molybdopterin synthase activity
RPE_RS04675	COG2890	protein-(glutamine-N5) methyltransferase activity
RPE_RS04680	COG0742	ribosomal rna small subunit methyltransferase
RPE_RS04685	COG1187	pseudouridine synthase activity
RPE_RS04690	COG0590	tRNA wobble adenosine to inosine editing
RPE_RS04700	COG1695	Transcriptional regulator
RPE_RS04705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPE_RS04710	COG1942	4-Oxalocrotonate Tautomerase
RPE_RS04735	COG0714	Associated with various cellular activities
RPE_RS04755	COG0617	tRNA 3'-terminal CCA addition
RPE_RS04765	COG0602	queuosine metabolic process
RPE_RS04770	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RPE_RS04775	COG0723	plastoquinol--plastocyanin reductase activity
RPE_RS04780	COG2857	Cytochrome c1
RPE_RS04780	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RPE_RS04795	COG0651	ATP synthesis coupled electron transport
RPE_RS04800	COG0650	Formate hydrogenlyase subunit 4
RPE_RS04810	COG0651	ATP synthesis coupled electron transport
RPE_RS04815	COG0649	NAD binding
RPE_RS04820	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS04840	COG0848	biopolymer transport protein
RPE_RS04855	COG1766	The M ring may be actively involved in energy transduction
RPE_RS04860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RPE_RS04870	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RPE_RS04875	COG2204	response regulator
RPE_RS04905	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPE_RS04925	COG0505	Belongs to the CarA family
RPE_RS04930	COG1610	YqeY-like protein
RPE_RS04935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RPE_RS04945	COG1013	pyruvate-flavodoxin oxidoreductase activity
RPE_RS04950	COG0674	pyruvate-flavodoxin oxidoreductase activity
RPE_RS04950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RPE_RS04965	COG3327	negative regulation of DNA-templated transcription, initiation
RPE_RS04970	COG3396	Phenylacetate-CoA oxygenase
RPE_RS04975	COG3460	Phenylacetate-CoA oxygenase
RPE_RS04980	COG3396	Phenylacetate-CoA oxygenase
RPE_RS04985	COG2151	metal-sulfur cluster biosynthetic enzyme
RPE_RS04990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
RPE_RS05000	COG1012	belongs to the aldehyde dehydrogenase family
RPE_RS05000	COG2030	dehydratase
RPE_RS05015	COG2050	protein possibly involved in aromatic compounds catabolism
RPE_RS05020	COG1024	Enoyl-CoA hydratase
RPE_RS05030	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPE_RS05055	COG2197	response regulator
RPE_RS05070	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
RPE_RS05095	COG2963	transposase activity
RPE_RS05100	COG3436	PFAM IS66 Orf2 family protein
RPE_RS05105	COG4372	Transposase
RPE_RS05180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPE_RS05250	COG0482	sulfurtransferase activity
RPE_RS05260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RPE_RS05265	COG2951	lytic endotransglycosylase activity
RPE_RS05330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RPE_RS05335	COG0358	DNA primase activity
RPE_RS05355	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPE_RS05365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RPE_RS05370	COG0534	Mate efflux family protein
RPE_RS05375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
RPE_RS05390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPE_RS05395	COG1722	exodeoxyribonuclease VII activity
RPE_RS05400	COG0123	including yeast histone deacetylase and acetoin utilization protein
RPE_RS05405	COG0737	Belongs to the 5'-nucleotidase family
RPE_RS05405	COG4085	toxin activity
RPE_RS05405	COG1525	nuclease
RPE_RS05420	COG1024	Enoyl-CoA hydratase
RPE_RS05425	COG1960	acyl-CoA dehydrogenase activity
RPE_RS05450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
RPE_RS05460	COG4372	Transposase
RPE_RS05470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RPE_RS05500	COG0489	protein tyrosine kinase activity
RPE_RS05510	COG3409	Peptidoglycan-binding domain 1 protein
RPE_RS05510	COG3267	Type II secretory pathway component ExeA
RPE_RS05565	COG0438	transferase activity, transferring glycosyl groups
RPE_RS05570	COG1215	transferase activity, transferring glycosyl groups
RPE_RS05575	COG0438	transferase activity, transferring glycosyl groups
RPE_RS05615	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RPE_RS05630	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RPE_RS05635	COG1696	Membrane protein involved in D-alanine export
RPE_RS05650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPE_RS05690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPE_RS05720	COG2963	transposase activity
RPE_RS05725	COG2963	transposase activity
RPE_RS05730	COG3436	PFAM IS66 Orf2 family protein
RPE_RS05735	COG4372	Transposase
RPE_RS05745	COG4372	Transposase
RPE_RS05775	COG3328	transposase activity
RPE_RS05785	COG3328	transposase activity
RPE_RS05810	COG1157	protein secretion by the type III secretion system
RPE_RS05815	COG4786	Flagellar basal body rod
RPE_RS05825	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RPE_RS05840	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RPE_RS05845	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RPE_RS05850	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RPE_RS05855	COG1815	bacterial-type flagellum-dependent cell motility
RPE_RS05860	COG1558	bacterial-type flagellum-dependent cell motility
RPE_RS05865	COG1677	Flagellar hook-basal body complex protein FliE
RPE_RS05870	COG4786	Flagellar basal body rod
RPE_RS05875	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
RPE_RS05880	COG1706	bacterial-type flagellum-dependent cell motility
RPE_RS05890	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RPE_RS05900	COG1338	Plays a role in the flagellum-specific transport system
RPE_RS05905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RPE_RS05920	COG1360	Flagellar Motor Protein
RPE_RS05935	COG0741	lytic transglycosylase activity
RPE_RS05940	COG1749	Flagellar hook protein flgE
RPE_RS05960	COG5443	negative regulation of bacterial-type flagellum assembly
RPE_RS05965	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RPE_RS05975	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RPE_RS06020	COG0438	transferase activity, transferring glycosyl groups
RPE_RS06040	COG0745	RESPONSE REGULATOR receiver
RPE_RS06045	COG2198	Histidine kinase
RPE_RS06045	COG0643	Histidine kinase
RPE_RS06050	COG0835	chemotaxis
RPE_RS06060	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RPE_RS06065	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
RPE_RS06080	COG1366	Belongs to the anti-sigma-factor antagonist family
RPE_RS06110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RPE_RS06115	COG0723	plastoquinol--plastocyanin reductase activity
RPE_RS06145	COG1960	acyl-CoA dehydrogenase activity
RPE_RS06160	COG3842	ATPase activity
RPE_RS06165	COG3665	Urea carboxylase-associated protein
RPE_RS06190	COG1309	transcriptional regulator
RPE_RS06200	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS06215	COG1454	alcohol dehydrogenase
RPE_RS06230	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RPE_RS06240	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RPE_RS06245	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RPE_RS06250	COG0298	carbon dioxide binding
RPE_RS06255	COG3118	belongs to the thioredoxin family
RPE_RS06260	COG1773	rubredoxin
RPE_RS06270	COG1773	rubredoxin
RPE_RS06275	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RPE_RS06280	COG0375	protein maturation
RPE_RS06290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RPE_RS06305	COG0309	Hydrogenase expression formation protein (HypE)
RPE_RS06310	COG2204	response regulator
RPE_RS06320	COG0420	3'-5' exonuclease activity
RPE_RS06360	COG0243	molybdopterin cofactor binding
RPE_RS06365	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
RPE_RS06370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPE_RS06375	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RPE_RS06385	COG1116	anion transmembrane transporter activity
RPE_RS06390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPE_RS06395	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS06400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS06400	COG1116	anion transmembrane transporter activity
RPE_RS06405	COG3707	response regulator
RPE_RS06425	COG0346	lactoylglutathione lyase activity
RPE_RS06430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RPE_RS06440	COG0784	Response regulator, receiver
RPE_RS06440	COG4191	Histidine kinase
RPE_RS06465	COG0471	metal ion transport
RPE_RS06530	COG2814	Major facilitator Superfamily
RPE_RS06545	COG2072	flavoprotein involved in K transport
RPE_RS06585	COG0181	hydroxymethylbilane synthase activity
RPE_RS06595	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RPE_RS06625	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RPE_RS06640	COG1233	COG1233 Phytoene dehydrogenase and related
RPE_RS06645	COG1562	ergosterol biosynthetic process
RPE_RS06650	COG0408	coproporphyrinogen oxidase activity
RPE_RS06675	COG0142	geranyltranstransferase activity
RPE_RS06680	COG0500	methyltransferase
RPE_RS06685	COG1063	alcohol dehydrogenase
RPE_RS06690	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RPE_RS06695	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS06700	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS06730	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RPE_RS06735	COG2211	Major facilitator Superfamily
RPE_RS06740	COG0644	oxidoreductase
RPE_RS06745	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
RPE_RS06755	COG3474	cytochrome
RPE_RS06765	COG4251	negative regulation of phosphorylation
RPE_RS06770	COG5398	heme oxygenase
RPE_RS06785	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS06790	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS06795	COG1429	ligase activity, forming nitrogen-metal bonds
RPE_RS06800	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RPE_RS06810	COG2814	Major facilitator Superfamily
RPE_RS06835	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RPE_RS06845	COG0156	8-amino-7-oxononanoate synthase activity
RPE_RS06855	COG1850	ribulose-bisphosphate carboxylase activity
RPE_RS06860	COG4451	ribulose bisphosphate carboxylase, small
RPE_RS06870	COG2267	carboxylic ester hydrolase activity
RPE_RS06885	COG2900	Belongs to the SlyX family
RPE_RS06895	COG3237	CsbD-like
RPE_RS06945	COG3842	ATPase activity
RPE_RS06950	COG3842	ATPase activity
RPE_RS06960	COG0395	ABC-type sugar transport system, permease component
RPE_RS06975	COG1902	pentaerythritol trinitrate reductase activity
RPE_RS06995	COG0411	ABC transporter
RPE_RS07010	COG3041	Addiction module toxin RelE StbE family
RPE_RS07045	COG0494	nUDIX hydrolase
RPE_RS07050	COG0668	transmembrane transport
RPE_RS07065	COG4453	Protein conserved in bacteria
RPE_RS07070	COG4771	TonB-dependent receptor
RPE_RS07100	COG0196	riboflavin kinase activity
RPE_RS07120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RPE_RS07125	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
RPE_RS07135	COG0612	Peptidase, M16
RPE_RS07140	COG0612	Peptidase, M16
RPE_RS07150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RPE_RS07165	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPE_RS07170	COG1846	Transcriptional regulator
RPE_RS07175	COG0745	RESPONSE REGULATOR receiver
RPE_RS07195	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RPE_RS07200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RPE_RS07210	COG1496	oxidoreductase activity
RPE_RS07220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RPE_RS07230	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RPE_RS07235	COG0193	aminoacyl-tRNA hydrolase activity
RPE_RS07240	COG0012	GTP binding
RPE_RS07250	COG2030	dehydratase
RPE_RS07280	COG1132	(ABC) transporter
RPE_RS07290	COG0859	PFAM glycosyl transferase family 9
RPE_RS07295	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RPE_RS07305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS07310	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RPE_RS07310	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RPE_RS07320	COG0673	inositol 2-dehydrogenase activity
RPE_RS07330	COG0728	peptidoglycan biosynthetic process
RPE_RS07335	COG2192	nodulation
RPE_RS07350	COG3909	cytochrome
RPE_RS07355	COG2010	Cytochrome c
RPE_RS07365	COG0351	phosphomethylpyrimidine kinase
RPE_RS07380	COG0438	transferase activity, transferring glycosyl groups
RPE_RS07395	COG2814	Major facilitator Superfamily
RPE_RS07400	COG4948	Mandelate Racemase Muconate Lactonizing
RPE_RS07415	COG3218	ABC-type transport auxiliary lipoprotein component
RPE_RS07415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPE_RS07430	COG0633	Ferredoxin
RPE_RS07440	COG0492	ferredoxin-NADP+ reductase activity
RPE_RS07455	COG0784	Response regulator, receiver
RPE_RS07455	COG4191	Histidine kinase
RPE_RS07500	COG3685	Protein conserved in bacteria
RPE_RS07545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPE_RS07555	COG1749	Flagellar hook protein flgE
RPE_RS07560	COG1256	bacterial-type flagellum assembly
RPE_RS07575	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RPE_RS07580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPE_RS07585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS07590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RPE_RS07620	COG1088	dTDP-glucose 4,6-dehydratase activity
RPE_RS07625	COG3959	Transketolase, thiamine diphosphate binding domain
RPE_RS07650	COG4106	trans-aconitate 2-methyltransferase activity
RPE_RS07665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RPE_RS07700	COG1706	bacterial-type flagellum-dependent cell motility
RPE_RS07730	COG4786	Flagellar basal body rod
RPE_RS07735	COG4786	Flagellar basal body rod
RPE_RS07770	COG0840	transmembrane signaling receptor activity
RPE_RS07790	COG1338	Plays a role in the flagellum-specific transport system
RPE_RS07805	COG1558	bacterial-type flagellum-dependent cell motility
RPE_RS07810	COG1677	Flagellar hook-basal body complex protein FliE
RPE_RS07815	COG1987	bacterial-type flagellum assembly
RPE_RS07820	COG1684	flagellar biosynthetic protein fliR
RPE_RS07825	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RPE_RS07895	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
RPE_RS07895	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
RPE_RS07915	COG2917	probably involved in intracellular septation
RPE_RS08015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RPE_RS08020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPE_RS08020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RPE_RS08025	COG0509	glycine decarboxylation via glycine cleavage system
RPE_RS08030	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RPE_RS08035	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RPE_RS08040	COG1505	serine-type exopeptidase activity
RPE_RS08055	COG4651	solute:proton antiporter activity
RPE_RS08055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RPE_RS08060	COG0538	isocitrate dehydrogenase activity
RPE_RS08090	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RPE_RS08095	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPE_RS08105	COG0047	phosphoribosylformylglycinamidine synthase activity
RPE_RS08120	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RPE_RS08145	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
RPE_RS08150	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPE_RS08155	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RPE_RS08160	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RPE_RS08215	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RPE_RS08230	COG1917	Cupin 2, conserved barrel domain protein
RPE_RS08230	COG1396	sequence-specific DNA binding
RPE_RS08240	COG3038	cytochrome b561
RPE_RS08255	COG4453	Protein conserved in bacteria
RPE_RS08260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RPE_RS08290	COG0785	Cytochrome C biogenesis protein
RPE_RS08330	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPE_RS08350	COG0542	response to heat
RPE_RS08365	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RPE_RS08365	COG3608	succinylglutamate desuccinylase aspartoacylase
RPE_RS08370	COG2068	MobA-Related Protein
RPE_RS08390	COG1309	transcriptional regulator
RPE_RS08400	COG1131	(ABC) transporter
RPE_RS08405	COG0842	Transport permease protein
RPE_RS08450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPE_RS08465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS08470	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPE_RS08475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RPE_RS08485	COG0596	Alpha beta hydrolase
RPE_RS08500	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPE_RS08505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPE_RS08510	COG0583	DNA-binding transcription factor activity
RPE_RS08515	COG4336	lyase activity
RPE_RS08545	COG2827	Endonuclease containing a URI domain
RPE_RS08550	COG3622	Belongs to the hyi family
RPE_RS08555	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS08570	COG1024	Enoyl-CoA hydratase
RPE_RS08585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RPE_RS08585	COG0678	peroxiredoxin activity
RPE_RS08590	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS08595	COG1686	Belongs to the peptidase S11 family
RPE_RS08600	COG1132	(ABC) transporter
RPE_RS08605	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS08610	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS08615	COG0649	NAD binding
RPE_RS08630	COG1034	ATP synthesis coupled electron transport
RPE_RS08635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPE_RS08640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS08645	COG0839	Belongs to the complex I subunit 6 family
RPE_RS08650	COG0713	ATP synthesis coupled electron transport
RPE_RS08655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RPE_RS08665	COG1007	ATP synthesis coupled electron transport
RPE_RS08675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS08680	COG0745	RESPONSE REGULATOR receiver
RPE_RS08685	COG4566	intracellular signal transduction
RPE_RS08690	COG4191	Histidine kinase
RPE_RS08720	COG2239	Acts as a magnesium transporter
RPE_RS08725	COG0045	succinate-CoA ligase (ADP-forming) activity
RPE_RS08725	COG1042	CoA-binding domain protein
RPE_RS08725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPE_RS08740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RPE_RS08745	COG1127	ABC transporter
RPE_RS08750	COG3218	ABC-type transport auxiliary lipoprotein component
RPE_RS08750	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RPE_RS08760	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS08765	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS08785	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RPE_RS08805	COG0784	Response regulator, receiver
RPE_RS08820	COG0628	permease
RPE_RS08825	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS08825	COG1388	LysM domain
RPE_RS08835	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RPE_RS08840	COG4208	sulfate ABC transporter
RPE_RS08850	COG4150	thiosulfate binding
RPE_RS08860	COG0175	sulfate reduction
RPE_RS08865	COG1648	precorrin-2 dehydrogenase activity
RPE_RS08865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RPE_RS08885	COG0175	sulfate reduction
RPE_RS08890	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
RPE_RS08895	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
RPE_RS08900	COG4208	sulfate ABC transporter
RPE_RS08905	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RPE_RS08915	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS08975	COG1024	Enoyl-CoA hydratase
RPE_RS08985	COG0583	DNA-binding transcription factor activity
RPE_RS08990	COG2855	membrane
RPE_RS08995	COG0784	Response regulator, receiver
RPE_RS08995	COG4191	Histidine kinase
RPE_RS09020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RPE_RS09030	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS09035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPE_RS09070	COG0028	Belongs to the TPP enzyme family
RPE_RS09085	COG0840	transmembrane signaling receptor activity
RPE_RS09090	COG4303	Ethanolamine ammonia lyase large subunit
RPE_RS09100	COG4302	ethanolamine ammonia-lyase activity
RPE_RS09120	COG1562	ergosterol biosynthetic process
RPE_RS09125	COG1562	ergosterol biosynthetic process
RPE_RS09130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
RPE_RS09135	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RPE_RS09145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPE_RS09170	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
RPE_RS09175	COG1473	amidohydrolase
RPE_RS09180	COG3685	Protein conserved in bacteria
RPE_RS09185	COG1573	uracil-dna glycosylase
RPE_RS09205	COG0587	DNA-directed DNA polymerase activity
RPE_RS09210	COG0454	-acetyltransferase
RPE_RS09220	COG3609	addiction module antidote protein, CC2985 family
RPE_RS09235	COG5001	Diguanylate cyclase
RPE_RS09235	COG3300	MHYT domain
RPE_RS09245	COG1024	Enoyl-CoA hydratase
RPE_RS09295	COG1703	isobutyryl-CoA mutase activity
RPE_RS09340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RPE_RS09350	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RPE_RS09365	COG0433	COG0433 Predicted ATPase
RPE_RS09400	COG4957	zinc ion binding
RPE_RS09410	COG2166	iron-sulfur cluster assembly
RPE_RS09420	COG2205	protein histidine kinase activity
RPE_RS09470	COG2983	Belongs to the UPF0260 family
RPE_RS09505	COG0840	transmembrane signaling receptor activity
RPE_RS09525	COG2827	Endonuclease containing a URI domain
RPE_RS09530	COG4695	Portal protein
RPE_RS09565	COG3328	transposase activity
RPE_RS09575	COG3328	transposase activity
RPE_RS09705	COG4235	cytochrome complex assembly
RPE_RS09710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RPE_RS09715	COG1138	Cytochrome C-type biogenesis protein
RPE_RS09720	COG3088	subunit of a heme lyase
RPE_RS09725	COG0523	cobalamin synthesis protein
RPE_RS09745	COG0745	RESPONSE REGULATOR receiver
RPE_RS09750	COG0840	transmembrane signaling receptor activity
RPE_RS09760	COG2205	protein histidine kinase activity
RPE_RS09765	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RPE_RS09785	COG3220	belongs to the UPF0276 family
RPE_RS09800	COG2202	Pas domain
RPE_RS09800	COG2205	protein histidine kinase activity
RPE_RS09815	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RPE_RS09835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPE_RS09840	COG1802	Transcriptional regulator
RPE_RS09845	COG3158	transport of potassium into the cell
RPE_RS09870	COG2205	protein histidine kinase activity
RPE_RS09885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
RPE_RS09890	COG0310	cobalt ion transport
RPE_RS09895	COG0310	cobalt ion transport
RPE_RS09930	COG2205	protein histidine kinase activity
RPE_RS09930	COG2202	Pas domain
RPE_RS09935	COG2084	Dehydrogenase
RPE_RS09940	COG0489	protein tyrosine kinase activity
RPE_RS09945	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RPE_RS09950	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RPE_RS09960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RPE_RS09970	COG0546	phosphoglycolate phosphatase activity
RPE_RS09975	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RPE_RS09995	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RPE_RS10000	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RPE_RS10010	COG1487	ribonuclease activity
RPE_RS10030	COG0215	cysteine-tRNA ligase activity
RPE_RS10045	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPE_RS10055	COG0028	Belongs to the TPP enzyme family
RPE_RS10060	COG0277	FAD linked oxidase domain protein
RPE_RS10070	COG5265	(ABC) transporter
RPE_RS10075	COG0688	phosphatidylethanolamine metabolic process
RPE_RS10080	COG1183	phosphatidylcholine synthase activity
RPE_RS10085	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RPE_RS10095	COG3158	transport of potassium into the cell
RPE_RS10105	COG0436	Aminotransferase
RPE_RS10110	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RPE_RS10125	COG1063	alcohol dehydrogenase
RPE_RS10130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPE_RS10135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPE_RS10140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPE_RS10145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPE_RS10155	COG1285	pathogenesis
RPE_RS10185	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPE_RS10190	COG3706	GGDEF domain
RPE_RS10190	COG4251	negative regulation of phosphorylation
RPE_RS10190	COG5001	Diguanylate cyclase
RPE_RS10190	COG2203	Gaf domain
RPE_RS10205	COG2897	thiosulfate sulfurtransferase activity
RPE_RS10215	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS10250	COG4106	trans-aconitate 2-methyltransferase activity
RPE_RS10275	COG3639	organic phosphonate transmembrane transporter activity
RPE_RS10280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RPE_RS10315	COG0840	transmembrane signaling receptor activity
RPE_RS10345	COG5001	Diguanylate cyclase
RPE_RS10345	COG2203	Gaf domain
RPE_RS10345	COG4251	negative regulation of phosphorylation
RPE_RS10345	COG3706	GGDEF domain
RPE_RS10370	COG1943	Transposase
RPE_RS10380	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
RPE_RS10390	COG2022	thiamine diphosphate biosynthetic process
RPE_RS10410	COG1252	NADH dehydrogenase
RPE_RS10430	COG1388	LysM domain
RPE_RS10430	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS10450	COG0667	Aldo Keto reductase
RPE_RS10455	COG1064	alcohol dehydrogenase
RPE_RS10475	COG0653	protein targeting
RPE_RS10495	COG1309	transcriptional regulator
RPE_RS10530	COG3023	N-Acetylmuramoyl-L-alanine amidase
RPE_RS10535	COG0275	rRNA processing
RPE_RS10550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RPE_RS10560	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPE_RS10565	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RPE_RS10575	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RPE_RS10580	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RPE_RS10590	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RPE_RS10600	COG0438	transferase activity, transferring glycosyl groups
RPE_RS10605	COG1181	Belongs to the D-alanine--D-alanine ligase family
RPE_RS10610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RPE_RS10615	COG0849	cell division
RPE_RS10620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RPE_RS10630	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RPE_RS10645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RPE_RS10650	COG2814	Major facilitator Superfamily
RPE_RS10655	COG0006	proline dipeptidase activity
RPE_RS10655	COG0006	proline dipeptidase activity
RPE_RS10665	COG2264	protein methyltransferase activity
RPE_RS10695	COG0842	Transport permease protein
RPE_RS10700	COG1131	(ABC) transporter
RPE_RS10710	COG1598	PFAM Uncharacterised protein family UPF0150
RPE_RS10720	COG0210	DNA helicase
RPE_RS10735	COG0277	FAD linked oxidase domain protein
RPE_RS10750	COG0114	fumarate hydratase activity
RPE_RS10775	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPE_RS10780	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPE_RS10850	COG0513	Belongs to the DEAD box helicase family
RPE_RS10875	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RPE_RS10890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPE_RS10905	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RPE_RS10925	COG0330	HflC and HflK could
RPE_RS10930	COG0330	HflC and HflK could
RPE_RS10960	COG0560	Phosphoserine phosphatase
RPE_RS10960	COG3830	Belongs to the UPF0237 family
RPE_RS10965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RPE_RS10970	COG0028	Belongs to the TPP enzyme family
RPE_RS10980	COG0440	acetolactate synthase activity
RPE_RS11005	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RPE_RS11035	COG1174	glycine betaine transport
RPE_RS11040	COG1125	glycine betaine transport
RPE_RS11040	COG0517	IMP dehydrogenase activity
RPE_RS11060	COG2326	polyphosphate kinase activity
RPE_RS11070	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RPE_RS11075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RPE_RS11110	COG1819	glycosyl
RPE_RS11130	COG1797	cobyrinic acid a,c-diamide synthase activity
RPE_RS11150	COG2099	Precorrin-6x reductase
RPE_RS11180	COG1053	succinate dehydrogenase
RPE_RS11185	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RPE_RS11200	COG0778	Nitroreductase
RPE_RS11230	COG1492	cobalamin metabolic process
RPE_RS11235	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RPE_RS11270	COG4191	Histidine kinase
RPE_RS11270	COG0784	Response regulator, receiver
RPE_RS11275	COG2010	Cytochrome c
RPE_RS11280	COG1960	acyl-CoA dehydrogenase activity
RPE_RS11285	COG1960	acyl-CoA dehydrogenase activity
RPE_RS11300	COG3246	L-lysine catabolic process to acetate
RPE_RS11305	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS11310	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPE_RS11320	COG1024	Enoyl-CoA hydratase
RPE_RS11335	COG0697	spore germination
RPE_RS11345	COG0129	dihydroxy-acid dehydratase activity
RPE_RS11390	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS11395	COG0640	Transcriptional regulator
RPE_RS11405	COG0640	Transcriptional regulator
RPE_RS11420	COG1846	Transcriptional regulator
RPE_RS11440	COG2226	methyltransferase
RPE_RS11450	COG3318	Belongs to the UPF0149 family
RPE_RS11450	COG3012	SEC-C Motif Domain Protein
RPE_RS11455	COG0459	protein refolding
RPE_RS11460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RPE_RS11465	COG5425	PFAM Usg family protein
RPE_RS11480	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
RPE_RS11500	COG4221	oxidoreductase activity
RPE_RS11510	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS11530	COG2308	Evidence 4 Homologs of previously reported genes of
RPE_RS11535	COG1546	Belongs to the CinA family
RPE_RS11535	COG1058	Belongs to the CinA family
RPE_RS11540	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RPE_RS11555	COG0625	glutathione transferase activity
RPE_RS11565	COG0604	alcohol dehydrogenase
RPE_RS11565	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
RPE_RS11565	COG3321	synthase
RPE_RS11565	COG4221	oxidoreductase activity
RPE_RS11570	COG1024	Enoyl-CoA hydratase
RPE_RS11655	COG3916	Acyl-homoserine-lactone synthase
RPE_RS11660	COG2197	response regulator
RPE_RS11675	COG4191	Histidine kinase
RPE_RS11675	COG0784	Response regulator, receiver
RPE_RS11680	COG0745	RESPONSE REGULATOR receiver
RPE_RS11705	COG1752	Esterase of the alpha-beta hydrolase superfamily
RPE_RS11715	COG5001	Diguanylate cyclase
RPE_RS11730	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RPE_RS11740	COG2814	Major facilitator Superfamily
RPE_RS11760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RPE_RS11785	COG0302	gtp cyclohydrolase
RPE_RS11790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RPE_RS11835	COG3706	GGDEF domain
RPE_RS11840	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RPE_RS11860	COG1278	Cold shock
RPE_RS11910	COG0183	Belongs to the thiolase family
RPE_RS11915	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS11925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPE_RS11925	COG0045	succinate-CoA ligase (ADP-forming) activity
RPE_RS11925	COG1042	CoA-binding domain protein
RPE_RS11930	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS11945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPE_RS11970	COG1960	acyl-CoA dehydrogenase activity
RPE_RS11985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPE_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS12005	COG0488	(ABC) transporter
RPE_RS12010	COG1671	Belongs to the UPF0178 family
RPE_RS12030	COG0386	Belongs to the glutathione peroxidase family
RPE_RS12040	COG3045	CreA protein
RPE_RS12065	COG2050	protein possibly involved in aromatic compounds catabolism
RPE_RS12080	COG1285	pathogenesis
RPE_RS12100	COG2365	Tyrosine phosphatase family
RPE_RS12115	COG4191	Histidine kinase
RPE_RS12120	COG0431	NADPH-dependent FMN reductase
RPE_RS12215	COG2963	transposase activity
RPE_RS12220	COG3436	PFAM IS66 Orf2 family protein
RPE_RS12225	COG4372	Transposase
RPE_RS12325	COG0840	transmembrane signaling receptor activity
RPE_RS12335	COG3300	MHYT domain
RPE_RS12335	COG5001	Diguanylate cyclase
RPE_RS12400	COG2925	Exonuclease
RPE_RS12410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPE_RS12415	COG1021	2,3-dihydroxybenzoate-AMP ligase
RPE_RS12455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPE_RS12490	COG3621	Patatin-like phospholipase
RPE_RS12540	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RPE_RS12545	COG0697	spore germination
RPE_RS12560	COG0174	glutamine synthetase
RPE_RS12565	COG0347	Belongs to the P(II) protein family
RPE_RS12570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RPE_RS12570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RPE_RS12585	COG0544	peptidyl-prolyl cis-trans isomerase activity
RPE_RS12590	COG0740	serine-type endopeptidase activity
RPE_RS12595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RPE_RS12600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RPE_RS12625	COG2195	Cleaves the N-terminal amino acid of tripeptides
RPE_RS12630	COG0776	regulation of translation
RPE_RS12650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS12655	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS12665	COG0649	NAD binding
RPE_RS12680	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RPE_RS12695	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RPE_RS12700	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RPE_RS12710	COG0713	ATP synthesis coupled electron transport
RPE_RS12725	COG1007	ATP synthesis coupled electron transport
RPE_RS12740	COG0346	lactoylglutathione lyase activity
RPE_RS12760	COG0442	prolyl-tRNA aminoacylation
RPE_RS12770	COG1136	(ABC) transporter
RPE_RS12805	COG0052	Belongs to the universal ribosomal protein uS2 family
RPE_RS12810	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RPE_RS12815	COG0528	UMP kinase activity
RPE_RS12820	COG0233	cytoplasmic translational termination
RPE_RS12825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RPE_RS12835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RPE_RS12840	COG0750	zinc metalloprotease
RPE_RS12845	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RPE_RS12850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPE_RS12855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RPE_RS12860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPE_RS12870	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPE_RS12875	COG0372	Belongs to the citrate synthase family
RPE_RS12880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPE_RS12885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPE_RS12895	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RPE_RS12900	COG0303	'Molybdopterin
RPE_RS12945	COG1011	Hydrolase
RPE_RS12965	COG0071	Belongs to the small heat shock protein (HSP20) family
RPE_RS12980	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RPE_RS12985	COG0315	cyclic pyranopterin monophosphate synthase activity
RPE_RS12990	COG0134	indole-3-glycerol-phosphate synthase activity
RPE_RS12995	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RPE_RS13005	COG0149	triose-phosphate isomerase activity
RPE_RS13015	COG0504	CTP synthase activity
RPE_RS13045	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RPE_RS13050	COG0493	'glutamate synthase
RPE_RS13050	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPE_RS13070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RPE_RS13075	COG0148	phosphopyruvate hydratase activity
RPE_RS13085	COG1280	lysine exporter protein (LysE YggA)
RPE_RS13090	COG0431	NADPH-dependent FMN reductase
RPE_RS13100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RPE_RS13110	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPE_RS13110	COG0022	dehydrogenase e1 component
RPE_RS13120	COG0508	dehydrogenase complex catalyzes the overall conversion of
RPE_RS13130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RPE_RS13145	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
RPE_RS13155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS13160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPE_RS13185	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RPE_RS13200	COG0741	lytic transglycosylase activity
RPE_RS13245	COG0542	response to heat
RPE_RS13355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RPE_RS13385	COG1450	Type ii and iii secretion system protein
RPE_RS13405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS13450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RPE_RS13470	COG1850	ribulose-bisphosphate carboxylase activity
RPE_RS13500	COG0018	arginyl-trna synthetase
RPE_RS13510	COG1472	Belongs to the glycosyl hydrolase 3 family
RPE_RS13515	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RPE_RS13520	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RPE_RS13525	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPE_RS13530	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RPE_RS13535	COG0805	protein transport
RPE_RS13545	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RPE_RS13560	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RPE_RS13570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPE_RS13585	COG2154	pterin-4-alpha-carbinolamine dehydratase
RPE_RS13595	COG1217	gtp-binding protein TYPA
RPE_RS13660	COG2373	Large extracellular alpha-helical protein
RPE_RS13665	COG4953	penicillin-binding protein 1C
RPE_RS13670	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
RPE_RS13675	COG0671	phosphoesterase, PA-phosphatase related
RPE_RS13680	COG0463	Glycosyl transferase, family 2
RPE_RS13690	COG0626	cystathionine gamma-synthase activity
RPE_RS13695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPE_RS13700	COG4597	amino acid ABC transporter
RPE_RS13705	COG0765	amino acid transport
RPE_RS13710	COG1126	abc transporter atp-binding protein
RPE_RS13725	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RPE_RS13750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPE_RS13795	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RPE_RS13810	COG0525	valine-tRNA ligase activity
RPE_RS13815	COG2094	Belongs to the DNA glycosylase MPG family
RPE_RS13820	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RPE_RS13825	COG2867	negative regulation of translational initiation
RPE_RS13830	COG1058	Belongs to the CinA family
RPE_RS13830	COG1546	Belongs to the CinA family
RPE_RS13835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RPE_RS13835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RPE_RS13855	COG5000	phosphorelay sensor kinase activity
RPE_RS13860	COG2204	response regulator
RPE_RS13865	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RPE_RS13870	COG1923	regulation of RNA biosynthetic process
RPE_RS13875	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RPE_RS13880	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RPE_RS13890	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RPE_RS13910	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RPE_RS13915	COG0343	queuine tRNA-ribosyltransferase activity
RPE_RS13990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RPE_RS13995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RPE_RS14015	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RPE_RS14045	COG0679	Auxin Efflux Carrier
RPE_RS14050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RPE_RS14055	COG1183	phosphatidylcholine synthase activity
RPE_RS14060	COG1253	flavin adenine dinucleotide binding
RPE_RS14110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RPE_RS14115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RPE_RS14120	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPE_RS14120	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RPE_RS14130	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RPE_RS14135	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RPE_RS14140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RPE_RS14145	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
RPE_RS14150	COG0596	Alpha beta hydrolase
RPE_RS14165	COG2197	response regulator
RPE_RS14190	COG0416	fatty acid biosynthetic process
RPE_RS14195	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RPE_RS14200	COG0776	regulation of translation
RPE_RS14255	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RPE_RS14260	COG1321	iron dependent repressor
RPE_RS14260	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RPE_RS14265	COG1121	(ABC) transporter
RPE_RS14270	COG0803	Belongs to the bacterial solute-binding protein 9 family
RPE_RS14285	COG0438	transferase activity, transferring glycosyl groups
RPE_RS14295	COG0489	protein tyrosine kinase activity
RPE_RS14295	COG3206	protein involved in exopolysaccharide biosynthesis
RPE_RS14315	COG1612	heme a metabolic process
RPE_RS14320	COG1993	acr, cog1993
RPE_RS14325	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPE_RS14330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RPE_RS14345	COG1024	Enoyl-CoA hydratase
RPE_RS14355	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RPE_RS14360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RPE_RS14365	COG3706	GGDEF domain
RPE_RS14385	COG2267	carboxylic ester hydrolase activity
RPE_RS14390	COG1686	Belongs to the peptidase S11 family
RPE_RS14395	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RPE_RS14410	COG0084	hydrolase, TatD family'
RPE_RS14415	COG0321	lipoyl(octanoyl) transferase activity
RPE_RS14415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RPE_RS14420	COG0583	DNA-binding transcription factor activity
RPE_RS14425	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RPE_RS14430	COG0477	Major facilitator Superfamily
RPE_RS14440	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS14445	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RPE_RS14450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RPE_RS14455	COG1368	sulfuric ester hydrolase activity
RPE_RS14460	COG0583	DNA-binding transcription factor activity
RPE_RS14490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
RPE_RS14495	COG3956	TIGRFAM MazG family protein
RPE_RS14500	COG1253	flavin adenine dinucleotide binding
RPE_RS14510	COG0629	single-stranded DNA binding
RPE_RS14520	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RPE_RS14580	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RPE_RS14600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RPE_RS14605	COG1862	Preprotein translocase
RPE_RS14625	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPE_RS14640	COG3033	Beta-eliminating lyase
RPE_RS14645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
RPE_RS14660	COG1278	Cold shock
RPE_RS14665	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RPE_RS14715	COG1509	lysine 2,3-aminomutase activity
RPE_RS14720	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
RPE_RS14725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RPE_RS14740	COG1289	transmembrane transporter activity
RPE_RS14750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPE_RS14755	COG1494	fructose-1,6-bisphosphatase
RPE_RS14765	COG0436	Aminotransferase
RPE_RS14775	COG3243	poly(R)-hydroxyalkanoic acid synthase
RPE_RS14780	COG3300	MHYT domain
RPE_RS14780	COG5001	Diguanylate cyclase
RPE_RS14800	COG0586	Pfam SNARE associated Golgi protein
RPE_RS14805	COG0187	DNA topoisomerase II activity
RPE_RS14810	COG1999	signal sequence binding
RPE_RS14855	COG4772	TonB-dependent receptor
RPE_RS14865	COG0513	Belongs to the DEAD box helicase family
RPE_RS14880	COG0316	Belongs to the HesB IscA family
RPE_RS14885	COG2151	metal-sulfur cluster biosynthetic enzyme
RPE_RS14890	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RPE_RS14895	COG0719	Fe-S assembly protein
RPE_RS14900	COG0396	ATPase activity
RPE_RS14910	COG0719	Fe-S assembly protein
RPE_RS14920	COG2945	thiolester hydrolase activity
RPE_RS14925	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RPE_RS14930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RPE_RS14940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RPE_RS14945	COG0739	heme binding
RPE_RS14955	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RPE_RS14965	COG1530	ribonuclease E activity
RPE_RS14965	COG1530	ribonuclease E activity
RPE_RS14970	COG0436	Aminotransferase
RPE_RS15000	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RPE_RS15005	COG0511	ligase activity, forming carbon-carbon bonds
RPE_RS15015	COG4191	Histidine kinase
RPE_RS15020	COG0784	Response regulator, receiver
RPE_RS15025	COG0745	RESPONSE REGULATOR receiver
RPE_RS15035	COG1032	radical SAM domain protein
RPE_RS15040	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RPE_RS15050	COG0657	acetylesterase activity
RPE_RS15065	COG3548	integral membrane protein
RPE_RS15115	COG0113	porphobilinogen synthase activity
RPE_RS15125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RPE_RS15140	COG3920	Histidine kinase
RPE_RS15145	COG1914	H( )-stimulated, divalent metal cation uptake system
RPE_RS15155	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RPE_RS15160	COG1381	Involved in DNA repair and RecF pathway recombination
RPE_RS15175	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RPE_RS15180	COG0571	ribonuclease III activity
RPE_RS15185	COG0681	Belongs to the peptidase S26 family
RPE_RS15190	COG0736	holo-[acyl-carrier-protein] synthase activity
RPE_RS15195	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RPE_RS15205	COG1758	RNA polymerase activity
RPE_RS15220	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RPE_RS15225	COG1970	mechanosensitive ion channel activity
RPE_RS15230	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPE_RS15240	COG2226	methyltransferase
RPE_RS15250	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
RPE_RS15250	COG0473	3-isopropylmalate dehydrogenase activity
RPE_RS15255	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RPE_RS15260	COG1984	allophanate hydrolase subunit 2
RPE_RS15265	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RPE_RS15270	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RPE_RS15300	COG0306	phosphate transporter
RPE_RS15305	COG1392	Phosphate transport regulator
RPE_RS15325	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPE_RS15340	COG0411	ABC transporter
RPE_RS15350	COG0469	pyruvate kinase activity
RPE_RS15355	COG1393	Belongs to the ArsC family
RPE_RS15375	COG0501	Belongs to the peptidase M48B family
RPE_RS15400	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPE_RS15405	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPE_RS15415	COG2391	methyltransferase activity
RPE_RS15425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RPE_RS15430	COG0737	Belongs to the 5'-nucleotidase family
RPE_RS15445	COG3258	Cytochrome c
RPE_RS15450	COG2010	Cytochrome c
RPE_RS15465	COG0785	Cytochrome C biogenesis protein
RPE_RS15475	COG0640	Transcriptional regulator
RPE_RS15485	COG0348	domain, Protein
RPE_RS15495	COG3909	cytochrome
RPE_RS15510	COG0716	FMN binding
RPE_RS15515	COG0783	Belongs to the Dps family
RPE_RS15535	COG4263	nitrous-oxide reductase activity
RPE_RS15565	COG1882	Formate acetyltransferase
RPE_RS15570	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
RPE_RS15575	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RPE_RS15580	COG3454	Phosphonate metabolism
RPE_RS15585	COG4778	phosphonate C-P lyase system protein PhnL
RPE_RS15590	COG4107	phosphonate C-P lyase system protein PhnK
RPE_RS15595	COG3627	carbon phosphorus lyase activity
RPE_RS15600	COG3626	phosphonate metabolism
RPE_RS15605	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RPE_RS15610	COG3624	Phosphonate C-P lyase system protein PhnG
RPE_RS15615	COG2188	Transcriptional regulator
RPE_RS15625	COG3639	organic phosphonate transmembrane transporter activity
RPE_RS15635	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RPE_RS15645	COG3454	Phosphonate metabolism
RPE_RS15650	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RPE_RS15655	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
RPE_RS15660	COG2894	cell division
RPE_RS15665	COG0850	regulation of cytokinetic process
RPE_RS15670	COG1492	cobalamin metabolic process
RPE_RS15675	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RPE_RS15690	COG1120	ATPase activity
RPE_RS15695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPE_RS15730	COG0714	Associated with various cellular activities
RPE_RS15740	COG2010	Cytochrome c
RPE_RS15745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RPE_RS15750	COG4993	Dehydrogenase
RPE_RS15760	COG3850	Histidine kinase
RPE_RS15780	COG0848	biopolymer transport protein
RPE_RS15800	COG4771	TonB-dependent receptor
RPE_RS15825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPE_RS15830	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RPE_RS15855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RPE_RS15865	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RPE_RS15870	COG1247	-acetyltransferase
RPE_RS15875	COG1982	Orn Lys Arg decarboxylase major
RPE_RS15885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RPE_RS15890	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RPE_RS15895	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RPE_RS15905	COG1396	sequence-specific DNA binding
RPE_RS15905	COG3800	Transcriptional regulator
RPE_RS15925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RPE_RS15940	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RPE_RS15945	COG1464	Belongs to the NlpA lipoprotein family
RPE_RS15950	COG2011	ABC-type metal ion transport system permease component
RPE_RS15955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RPE_RS15960	COG1045	serine acetyltransferase
RPE_RS15965	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RPE_RS15970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS15975	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS15985	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RPE_RS15995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS16000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPE_RS16005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPE_RS16010	COG1116	anion transmembrane transporter activity
RPE_RS16015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RPE_RS16020	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS16025	COG0385	Bile acid
RPE_RS16040	COG0028	Belongs to the TPP enzyme family
RPE_RS16045	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RPE_RS16055	COG1012	belongs to the aldehyde dehydrogenase family
RPE_RS16060	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS16115	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RPE_RS16145	COG1960	acyl-CoA dehydrogenase activity
RPE_RS16150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPE_RS16150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPE_RS16155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPE_RS16155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RPE_RS16160	COG1024	Enoyl-CoA hydratase
RPE_RS16340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPE_RS16350	COG0582	viral genome integration into host DNA
RPE_RS16355	COG0519	Catalyzes the synthesis of GMP from XMP
RPE_RS16355	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RPE_RS16375	COG2130	NADP-dependent
RPE_RS16405	COG0477	Major facilitator Superfamily
RPE_RS16410	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RPE_RS16425	COG0281	malic enzyme
RPE_RS16425	COG0280	phosphate acetyltransferase
RPE_RS16430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RPE_RS16435	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RPE_RS16440	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RPE_RS16445	COG3781	membrane
RPE_RS16455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RPE_RS16465	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RPE_RS16470	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RPE_RS16475	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RPE_RS16480	COG1278	Cold shock
RPE_RS16485	COG0105	UTP biosynthetic process
RPE_RS16495	COG0488	(ABC) transporter
RPE_RS16510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPE_RS16525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
RPE_RS16540	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPE_RS16560	COG0194	GDP metabolic process
RPE_RS16565	COG1561	YicC-like family, N-terminal region
RPE_RS16570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RPE_RS16575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RPE_RS16580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RPE_RS16590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RPE_RS16600	COG0360	Binds together with S18 to 16S ribosomal RNA
RPE_RS16605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RPE_RS16630	COG0359	binds to the 23S rRNA
RPE_RS16645	COG0305	Participates in initiation and elongation during chromosome replication
RPE_RS16660	COG1136	(ABC) transporter
RPE_RS16660	COG0577	efflux transmembrane transporter activity
RPE_RS16670	COG2205	protein histidine kinase activity
RPE_RS16675	COG0745	RESPONSE REGULATOR receiver
RPE_RS16685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS16690	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPE_RS16705	COG0454	-acetyltransferase
RPE_RS16710	COG3706	GGDEF domain
RPE_RS16715	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RPE_RS16740	COG1286	toxin biosynthetic process
RPE_RS16745	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RPE_RS16750	COG0300	oxidoreductase activity
RPE_RS16770	COG1160	GTP binding
RPE_RS16785	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RPE_RS16795	COG3181	Tripartite tricarboxylate transporter family receptor
RPE_RS16815	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPE_RS16825	COG0154	amidase activity
RPE_RS16845	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RPE_RS16850	COG2070	2-Nitropropane dioxygenase
RPE_RS16870	COG4716	Myosin-crossreactive antigen
RPE_RS16875	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RPE_RS16885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS16890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS16900	COG0540	Belongs to the ATCase OTCase family
RPE_RS16905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RPE_RS16910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RPE_RS16920	COG0758	DNA mediated transformation
RPE_RS16930	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RPE_RS16935	COG0557	exoribonuclease II activity
RPE_RS16950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RPE_RS16965	COG0784	Response regulator, receiver
RPE_RS16975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RPE_RS17010	COG0537	adenosine 5'-monophosphoramidase activity
RPE_RS17015	COG1720	tRNA m6t6A37 methyltransferase activity
RPE_RS17040	COG0156	8-amino-7-oxononanoate synthase activity
RPE_RS17045	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RPE_RS17050	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RPE_RS17065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RPE_RS17075	COG1686	Belongs to the peptidase S11 family
RPE_RS17105	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RPE_RS17140	COG0656	L-ascorbic acid biosynthetic process
RPE_RS17150	COG2239	Acts as a magnesium transporter
RPE_RS17160	COG0726	polysaccharide deacetylase
RPE_RS17175	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
RPE_RS17180	COG3052	prosthetic group binding
RPE_RS17200	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
RPE_RS17225	COG0321	lipoyl(octanoyl) transferase activity
RPE_RS17230	COG1254	Belongs to the acylphosphatase family
RPE_RS17235	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
RPE_RS17240	COG4770	biotin carboxylase activity
RPE_RS17255	COG0415	Belongs to the DNA photolyase family
RPE_RS17270	COG3706	GGDEF domain
RPE_RS17285	COG0642	Histidine kinase
RPE_RS17290	COG0745	RESPONSE REGULATOR receiver
RPE_RS17295	COG0438	transferase activity, transferring glycosyl groups
RPE_RS17305	COG0586	Pfam SNARE associated Golgi protein
RPE_RS17310	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RPE_RS17315	COG0745	RESPONSE REGULATOR receiver
RPE_RS17325	COG1196	nuclear chromosome segregation
RPE_RS17325	COG0739	heme binding
RPE_RS17325	COG0741	lytic transglycosylase activity
RPE_RS17370	COG0811	peptide transport
RPE_RS17375	COG2831	hemolysin activation secretion protein
RPE_RS17455	COG1720	tRNA m6t6A37 methyltransferase activity
RPE_RS17465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RPE_RS17470	COG1120	ATPase activity
RPE_RS17490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPE_RS17505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS17540	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RPE_RS17555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPE_RS17585	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
RPE_RS17590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS17600	COG2197	response regulator
RPE_RS17615	COG4372	Transposase
RPE_RS17620	COG3436	PFAM IS66 Orf2 family protein
RPE_RS17625	COG2963	transposase activity
RPE_RS17670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RPE_RS17675	COG2030	dehydratase
RPE_RS17710	COG3591	Belongs to the peptidase S1B family
RPE_RS17710	COG1864	DNA RNA non-specific endonuclease
RPE_RS17740	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RPE_RS17750	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RPE_RS17800	COG0432	Pfam Uncharacterised protein family UPF0047
RPE_RS17805	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
RPE_RS17815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RPE_RS17820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPE_RS17835	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS17840	COG0203	ribosomal protein L17
RPE_RS17845	COG0202	RNA polymerase activity
RPE_RS17850	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RPE_RS17855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RPE_RS17860	COG0563	adenylate kinase activity
RPE_RS17865	COG0201	protein transport
RPE_RS17870	COG0200	Binds to the 23S rRNA
RPE_RS17875	COG1841	ribosomal large subunit assembly
RPE_RS17880	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RPE_RS17885	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RPE_RS17890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RPE_RS17895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RPE_RS17900	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RPE_RS17905	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RPE_RS17910	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RPE_RS17915	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RPE_RS17920	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RPE_RS17925	COG0255	Belongs to the universal ribosomal protein uL29 family
RPE_RS17930	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RPE_RS17935	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RPE_RS17940	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RPE_RS17945	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RPE_RS17950	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RPE_RS17955	COG0089	rRNA binding
RPE_RS17960	COG0088	Forms part of the polypeptide exit tunnel
RPE_RS17965	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RPE_RS17970	COG0051	transcription antitermination factor activity, RNA binding
RPE_RS17975	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPE_RS17980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPE_RS17985	COG0049	tRNA binding
RPE_RS18000	COG0445	tRNA wobble uridine modification
RPE_RS18005	COG1132	(ABC) transporter
RPE_RS18015	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RPE_RS18020	COG0085	RNA polymerase activity
RPE_RS18025	COG0222	ribosome binding
RPE_RS18030	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RPE_RS18055	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RPE_RS18060	COG0081	regulation of translation
RPE_RS18065	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RPE_RS18075	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RPE_RS18095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RPE_RS18110	COG0406	alpha-ribazole phosphatase activity
RPE_RS18115	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS18125	COG1960	acyl-CoA dehydrogenase activity
RPE_RS18145	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPE_RS18150	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RPE_RS18180	COG0643	Histidine kinase
RPE_RS18180	COG2198	Histidine kinase
RPE_RS18185	COG0745	RESPONSE REGULATOR receiver
RPE_RS18190	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RPE_RS18200	COG2201	protein-glutamate methylesterase activity
RPE_RS18205	COG0835	chemotaxis
RPE_RS18220	COG1295	ribonuclease BN
RPE_RS18225	COG2261	transglycosylase associated protein
RPE_RS18230	COG2267	carboxylic ester hydrolase activity
RPE_RS18235	COG0492	ferredoxin-NADP+ reductase activity
RPE_RS18240	COG1640	4-alpha-glucanotransferase
RPE_RS18245	COG3546	catalase activity
RPE_RS18255	COG0708	Exodeoxyribonuclease III
RPE_RS18260	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS18270	COG0243	molybdopterin cofactor binding
RPE_RS18280	COG3459	Glycosyltransferase 36 associated
RPE_RS18300	COG0798	PFAM Bile acid sodium symporter
RPE_RS18330	COG0640	Transcriptional regulator
RPE_RS18340	COG3685	Protein conserved in bacteria
RPE_RS18405	COG0662	Cupin 2, conserved barrel domain protein
RPE_RS18410	COG1850	ribulose-bisphosphate carboxylase activity
RPE_RS18435	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RPE_RS18440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS18445	COG0395	ABC-type sugar transport system, permease component
RPE_RS18460	COG3842	ATPase activity
RPE_RS18465	COG0129	dihydroxy-acid dehydratase activity
RPE_RS18470	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS18475	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS18485	COG1012	belongs to the aldehyde dehydrogenase family
RPE_RS18485	COG1454	alcohol dehydrogenase
RPE_RS18500	COG4251	negative regulation of phosphorylation
RPE_RS18500	COG2203	Gaf domain
RPE_RS18500	COG5001	Diguanylate cyclase
RPE_RS18500	COG3706	GGDEF domain
RPE_RS18505	COG3335	DDE superfamily endonuclease
RPE_RS18525	COG2827	Endonuclease containing a URI domain
RPE_RS18535	COG0386	Belongs to the glutathione peroxidase family
RPE_RS18540	COG0154	amidase activity
RPE_RS18560	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RPE_RS18565	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
RPE_RS18570	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RPE_RS18575	COG0363	glucosamine-6-phosphate deaminase activity
RPE_RS18580	COG3265	gluconokinase activity
RPE_RS18590	COG3387	PFAM Glycoside hydrolase 15-related
RPE_RS18595	COG1640	4-alpha-glucanotransferase
RPE_RS18600	COG0366	Alpha amylase catalytic
RPE_RS18610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RPE_RS18640	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
RPE_RS18655	COG0746	molybdenum cofactor guanylyltransferase activity
RPE_RS18660	COG0830	nickel cation binding
RPE_RS18665	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RPE_RS18675	COG0804	urea catabolic process
RPE_RS18680	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RPE_RS18685	COG0832	Belongs to the urease beta subunit family
RPE_RS18690	COG0831	urea catabolic process
RPE_RS18695	COG0829	nickel cation binding
RPE_RS18705	COG0411	ABC transporter
RPE_RS18725	COG0513	Belongs to the DEAD box helicase family
RPE_RS18730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RPE_RS18735	COG1278	Cold shock
RPE_RS18760	COG4964	Belongs to the GSP D family
RPE_RS18795	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RPE_RS18810	COG4172	Belongs to the ABC transporter superfamily
RPE_RS18825	COG4239	(ABC) transporter, permease
RPE_RS18830	COG4174	ABC transporter (Permease)
RPE_RS18835	COG4166	transmembrane transport
RPE_RS18840	COG4166	transmembrane transport
RPE_RS18845	COG3474	cytochrome
RPE_RS18850	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RPE_RS18860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RPE_RS18875	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RPE_RS18885	COG1960	acyl-CoA dehydrogenase activity
RPE_RS18890	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS18895	COG0183	Belongs to the thiolase family
RPE_RS18900	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS18960	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RPE_RS18960	COG0475	glutathione-regulated potassium exporter activity
RPE_RS18965	COG0840	transmembrane signaling receptor activity
RPE_RS19020	COG1024	Enoyl-CoA hydratase
RPE_RS19030	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RPE_RS19050	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS19080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RPE_RS19110	COG1960	acyl-CoA dehydrogenase activity
RPE_RS19115	COG1960	acyl-CoA dehydrogenase activity
RPE_RS19135	COG0183	Belongs to the thiolase family
RPE_RS19140	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS19155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RPE_RS19155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPE_RS19165	COG0583	DNA-binding transcription factor activity
RPE_RS19170	COG1546	Belongs to the CinA family
RPE_RS19170	COG1058	Belongs to the CinA family
RPE_RS19200	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RPE_RS19225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RPE_RS19230	COG0776	regulation of translation
RPE_RS19240	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RPE_RS19260	COG4603	Belongs to the binding-protein-dependent transport system permease family
RPE_RS19285	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
RPE_RS19310	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RPE_RS19315	COG0857	belongs to the CobB CobQ family
RPE_RS19315	COG0280	phosphate acetyltransferase
RPE_RS19335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPE_RS19335	COG2010	Cytochrome c
RPE_RS19340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPE_RS19350	COG1320	monovalent cation:proton antiporter activity
RPE_RS19355	COG2212	antiporter activity
RPE_RS19365	COG0651	ATP synthesis coupled electron transport
RPE_RS19370	COG1006	Multisubunit Na H antiporter MnhC subunit
RPE_RS19375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RPE_RS19375	COG2111	Na H antiporter
RPE_RS19440	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RPE_RS19460	COG1116	anion transmembrane transporter activity
RPE_RS19465	COG0528	UMP kinase activity
RPE_RS19470	COG0528	UMP kinase activity
RPE_RS19515	COG3237	CsbD-like
RPE_RS19585	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS19595	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS19600	COG4566	intracellular signal transduction
RPE_RS19615	COG3706	GGDEF domain
RPE_RS19615	COG2203	Gaf domain
RPE_RS19615	COG4251	negative regulation of phosphorylation
RPE_RS19615	COG5001	Diguanylate cyclase
RPE_RS19635	COG0643	Histidine kinase
RPE_RS19635	COG0784	Response regulator, receiver
RPE_RS19635	COG2198	Histidine kinase
RPE_RS19645	COG0840	transmembrane signaling receptor activity
RPE_RS19660	COG0515	serine threonine protein kinase
RPE_RS19660	COG2815	serine threonine protein kinase
RPE_RS19675	COG1032	radical SAM domain protein
RPE_RS19680	COG1719	4-vinyl reductase, 4VR
RPE_RS19685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RPE_RS19700	COG1937	Protein conserved in bacteria
RPE_RS19715	COG0720	synthase
RPE_RS19745	COG3335	DDE superfamily endonuclease
RPE_RS19750	COG1136	(ABC) transporter
RPE_RS19760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS19765	COG0596	Alpha beta hydrolase
RPE_RS19785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPE_RS19790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPE_RS19800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RPE_RS19805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RPE_RS19815	COG1522	sequence-specific DNA binding
RPE_RS19820	COG0492	ferredoxin-NADP+ reductase activity
RPE_RS19825	COG0583	DNA-binding transcription factor activity
RPE_RS19830	COG1192	Involved in chromosome partitioning
RPE_RS19850	COG1584	GPR1 FUN34 yaaH family protein
RPE_RS19880	COG0824	Thioesterase
RPE_RS19885	COG0723	plastoquinol--plastocyanin reductase activity
RPE_RS19895	COG0583	DNA-binding transcription factor activity
RPE_RS19905	COG0450	alkyl hydroperoxide reductase
RPE_RS19925	COG0446	pyridine nucleotide-disulphide oxidoreductase
RPE_RS19970	COG0582	viral genome integration into host DNA
RPE_RS20050	COG4372	Transposase
RPE_RS20055	COG3436	PFAM IS66 Orf2 family protein
RPE_RS20060	COG2963	transposase activity
RPE_RS20095	COG3451	type IV secretory pathway VirB4
RPE_RS20110	COG4962	Type ii secretion system protein e
RPE_RS20135	COG0681	Belongs to the peptidase S26 family
RPE_RS20160	COG1476	TRANSCRIPTIONal
RPE_RS20165	COG5489	Protein of unknown function (DUF736)
RPE_RS20205	COG0776	regulation of translation
RPE_RS20270	COG0210	DNA helicase
RPE_RS20305	COG2205	protein histidine kinase activity
RPE_RS20335	COG0840	transmembrane signaling receptor activity
RPE_RS20350	COG1262	PFAM Formylglycine-generating sulfatase enzyme
RPE_RS20355	COG1840	ABC-type Fe3 transport system, periplasmic component
RPE_RS20395	COG1177	transmembrane transport
RPE_RS20400	COG1176	ABC-type spermidine putrescine transport system, permease component I
RPE_RS20405	COG3842	ATPase activity
RPE_RS20410	COG5001	Diguanylate cyclase
RPE_RS20410	COG3300	MHYT domain
RPE_RS20415	COG0579	oxidoreductase
RPE_RS20430	COG5001	Diguanylate cyclase
RPE_RS20430	COG3447	MASE1 domain protein
RPE_RS20430	COG5002	protein histidine kinase activity
RPE_RS20435	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RPE_RS20440	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RPE_RS20445	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RPE_RS20465	COG0387	Pfam Sodium calcium exchanger
RPE_RS20505	COG0861	Integral membrane protein TerC family
RPE_RS20510	COG2204	response regulator
RPE_RS20515	COG2989	Protein conserved in bacteria
RPE_RS20525	COG3750	Belongs to the UPF0335 family
RPE_RS20540	COG0469	pyruvate kinase activity
RPE_RS20545	COG1598	PFAM Uncharacterised protein family UPF0150
RPE_RS20550	COG1764	response to oxidative stress
RPE_RS20565	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RPE_RS20600	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
RPE_RS20620	COG1960	acyl-CoA dehydrogenase activity
RPE_RS20625	COG1024	Enoyl-CoA hydratase
RPE_RS20630	COG0328	RNA-DNA hybrid ribonuclease activity
RPE_RS20635	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
RPE_RS20640	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RPE_RS20675	COG1487	ribonuclease activity
RPE_RS20695	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RPE_RS20705	COG2944	sequence-specific DNA binding
RPE_RS20715	COG1858	cytochrome C peroxidase
RPE_RS20720	COG5001	Diguanylate cyclase
RPE_RS20725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
RPE_RS20735	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RPE_RS20745	COG0656	L-ascorbic acid biosynthetic process
RPE_RS20785	COG0840	transmembrane signaling receptor activity
RPE_RS20790	COG0840	transmembrane signaling receptor activity
RPE_RS20795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RPE_RS20800	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RPE_RS20810	COG0625	glutathione transferase activity
RPE_RS20825	COG2223	nitrite transmembrane transporter activity
RPE_RS20830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPE_RS20835	COG1304	FMN binding
RPE_RS20840	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RPE_RS20850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RPE_RS20880	COG2133	pyrroloquinoline quinone binding
RPE_RS20895	COG0667	Aldo Keto reductase
RPE_RS20910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RPE_RS20920	COG0625	glutathione transferase activity
RPE_RS20930	COG2015	COG2015, Alkyl sulfatase and related hydrolases
RPE_RS20940	COG0556	nucleotide-excision repair
RPE_RS20955	COG3657	addiction module killer protein
RPE_RS20960	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RPE_RS20975	COG0183	Belongs to the thiolase family
RPE_RS20995	COG0702	epimerase
RPE_RS21005	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RPE_RS21015	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
RPE_RS21030	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
RPE_RS21035	COG0410	ABC transporter
RPE_RS21055	COG3547	Transposase (IS116 IS110 IS902 family)
RPE_RS21070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RPE_RS21075	COG1086	Polysaccharide biosynthesis protein
RPE_RS21080	COG0788	formyltetrahydrofolate deformylase activity
RPE_RS21120	COG1022	Amp-dependent synthetase and ligase
RPE_RS21125	COG2852	Protein conserved in bacteria
RPE_RS21130	COG0559	Belongs to the binding-protein-dependent transport system permease family
RPE_RS21155	COG1012	belongs to the aldehyde dehydrogenase family
RPE_RS21160	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS21165	COG2089	acid synthase
RPE_RS21175	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RPE_RS21180	COG1083	cytidylyl-transferase
RPE_RS21245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RPE_RS21250	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RPE_RS21265	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
RPE_RS21285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RPE_RS21305	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RPE_RS21320	COG1595	DNA-templated transcription, initiation
RPE_RS21340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RPE_RS21355	COG1280	lysine exporter protein (LysE YggA)
RPE_RS21365	COG0840	transmembrane signaling receptor activity
RPE_RS21375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RPE_RS21380	COG2942	2-epimerase
RPE_RS21390	COG2201	protein-glutamate methylesterase activity
RPE_RS21395	COG0643	Histidine kinase
RPE_RS21395	COG0784	Response regulator, receiver
RPE_RS21395	COG2198	Histidine kinase
RPE_RS21405	COG0784	Response regulator, receiver
RPE_RS21405	COG0643	Histidine kinase
RPE_RS21405	COG2198	Histidine kinase
RPE_RS21460	COG0310	cobalt ion transport
RPE_RS21485	COG0028	Belongs to the TPP enzyme family
RPE_RS21490	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS21500	COG0501	Belongs to the peptidase M48B family
RPE_RS21515	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
RPE_RS21520	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RPE_RS21535	COG1960	acyl-CoA dehydrogenase activity
RPE_RS21545	COG1272	protein, Hemolysin III
RPE_RS21550	COG3106	COG3106 Predicted ATPase
RPE_RS21555	COG3768	UPF0283 membrane protein
RPE_RS21560	COG1278	Cold shock
RPE_RS21595	COG1704	LemA family
RPE_RS21605	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS21630	COG0438	transferase activity, transferring glycosyl groups
RPE_RS21685	COG0739	heme binding
RPE_RS21695	COG0542	response to heat
RPE_RS21705	COG2813	Specifically methylates the guanine in position
RPE_RS21705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPE_RS21710	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RPE_RS21720	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RPE_RS21725	COG0287	Prephenate dehydrogenase
RPE_RS21745	COG0598	Magnesium transport protein CorA
RPE_RS21750	COG1376	ErfK ybiS ycfS ynhG family protein
RPE_RS21760	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS21765	COG2852	Protein conserved in bacteria
RPE_RS21780	COG1960	acyl-CoA dehydrogenase activity
RPE_RS21805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RPE_RS21815	COG0129	dihydroxy-acid dehydratase activity
RPE_RS21820	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RPE_RS21820	COG1618	nucleotide phosphatase activity, acting on free nucleotides
RPE_RS21825	COG2005	Transcriptional regulator
RPE_RS21825	COG3585	molybdate ion transport
RPE_RS21835	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RPE_RS21835	COG1618	nucleotide phosphatase activity, acting on free nucleotides
RPE_RS21875	COG1231	oxidoreductase activity
RPE_RS21880	COG1672	PFAM Archaeal ATPase
RPE_RS21880	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RPE_RS21895	COG0009	L-threonylcarbamoyladenylate synthase
RPE_RS21900	COG0277	FAD linked oxidase domain protein
RPE_RS21910	COG2135	peptidase activity
RPE_RS21940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RPE_RS21945	COG0354	folic acid binding
RPE_RS21950	COG0519	Catalyzes the synthesis of GMP from XMP
RPE_RS21955	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RPE_RS21985	COG0604	alcohol dehydrogenase
RPE_RS21990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
RPE_RS21995	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
RPE_RS22015	COG0574	Belongs to the PEP-utilizing enzyme family
RPE_RS22015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RPE_RS22030	COG0751	glycine-tRNA ligase activity
RPE_RS22035	COG2852	Protein conserved in bacteria
RPE_RS22040	COG0752	glycyl-tRNA synthetase alpha subunit
RPE_RS22065	COG0142	geranyltranstransferase activity
RPE_RS22075	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RPE_RS22090	COG1573	uracil-dna glycosylase
RPE_RS22100	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RPE_RS22115	COG1846	Transcriptional regulator
RPE_RS22115	COG0456	acetyltransferase
RPE_RS22120	COG0521	Mo-molybdopterin cofactor biosynthetic process
RPE_RS22125	COG2321	neutral zinc metallopeptidase
RPE_RS22130	COG2189	Belongs to the N(4) N(6)-methyltransferase family
RPE_RS22140	COG1194	a g-specific adenine glycosylase
RPE_RS22170	COG0501	Belongs to the peptidase M48B family
RPE_RS22175	COG1704	LemA family
RPE_RS22185	COG1196	nuclear chromosome segregation
RPE_RS22225	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RPE_RS22235	COG2824	Alkylphosphonate utilization operon protein PhnA
RPE_RS22260	COG1858	cytochrome C peroxidase
RPE_RS22265	COG1032	radical SAM domain protein
RPE_RS22280	COG2358	TRAP transporter, solute receptor (TAXI family
RPE_RS22310	COG1657	PFAM Prenyltransferase squalene oxidase
RPE_RS22325	COG0494	nUDIX hydrolase
RPE_RS22345	COG3550	peptidyl-serine autophosphorylation
RPE_RS22350	COG1396	sequence-specific DNA binding
RPE_RS22365	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RPE_RS22370	COG0424	maF-like protein
RPE_RS22385	COG5328	Belongs to the UPF0262 family
RPE_RS22390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RPE_RS22410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RPE_RS22440	COG0492	ferredoxin-NADP+ reductase activity
RPE_RS22460	COG2197	response regulator
RPE_RS22475	COG1162	GTPase activity
RPE_RS22480	COG1324	tolerance protein
RPE_RS22490	COG1397	ADP-ribosylglycohydrolase
RPE_RS22505	COG2226	methyltransferase
RPE_RS22510	COG2076	Multidrug Resistance protein
RPE_RS22515	COG0598	Magnesium transport protein CorA
RPE_RS22520	COG0494	nUDIX hydrolase
RPE_RS22545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPE_RS22550	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
RPE_RS22555	COG0644	oxidoreductase
RPE_RS22560	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RPE_RS22565	COG2086	electron transfer activity
RPE_RS22580	COG1104	cysteine desulfurase activity
RPE_RS22590	COG0316	Belongs to the HesB IscA family
RPE_RS22600	COG3383	formate dehydrogenase (NAD+) activity
RPE_RS22605	COG5420	small protein containing a coiled-coil domain
RPE_RS22620	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS22625	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS22630	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RPE_RS22640	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RPE_RS22650	COG5554	nitrogen fixation
RPE_RS22660	COG5554	nitrogen fixation
RPE_RS22675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPE_RS22685	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RPE_RS22690	COG3604	Transcriptional regulator
RPE_RS22695	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS22705	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS22730	COG0477	Major facilitator Superfamily
RPE_RS22735	COG1877	trehalose-phosphatase activity
RPE_RS22740	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
RPE_RS22860	COG1477	protein flavinylation
RPE_RS22865	COG3128	pkhd-type hydroxylase
RPE_RS22870	COG4774	siderophore transport
RPE_RS22880	COG0848	biopolymer transport protein
RPE_RS22890	COG0653	protein targeting
RPE_RS22910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RPE_RS22925	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RPE_RS22935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RPE_RS22950	COG0259	pyridoxamine-phosphate oxidase activity
RPE_RS22955	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS22995	COG0784	Response regulator, receiver
RPE_RS22995	COG5002	protein histidine kinase activity
RPE_RS22995	COG2198	Histidine kinase
RPE_RS23000	COG0745	RESPONSE REGULATOR receiver
RPE_RS23025	COG0318	PFAM AMP-dependent synthetase and ligase
RPE_RS23040	COG0151	Belongs to the GarS family
RPE_RS23065	COG1570	exodeoxyribonuclease VII activity
RPE_RS23075	COG2723	6-phospho-beta-galactosidase activity
RPE_RS23105	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RPE_RS23110	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RPE_RS23115	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RPE_RS23120	COG2205	protein histidine kinase activity
RPE_RS23125	COG0745	RESPONSE REGULATOR receiver
RPE_RS23160	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
RPE_RS23165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS23165	COG1116	anion transmembrane transporter activity
RPE_RS23170	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RPE_RS23175	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RPE_RS23180	COG3604	Transcriptional regulator
RPE_RS23195	COG1864	DNA RNA non-specific endonuclease
RPE_RS23195	COG3591	Belongs to the peptidase S1B family
RPE_RS23210	COG2223	nitrite transmembrane transporter activity
RPE_RS23220	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RPE_RS23225	COG3383	formate dehydrogenase (NAD+) activity
RPE_RS23240	COG0583	DNA-binding transcription factor activity
RPE_RS23255	COG0640	Transcriptional regulator
RPE_RS23285	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RPE_RS23310	COG0840	transmembrane signaling receptor activity
RPE_RS23315	COG0842	Transport permease protein
RPE_RS23320	COG0842	Transport permease protein
RPE_RS23320	COG1129	ABC transporter
RPE_RS23325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RPE_RS23340	COG2201	protein-glutamate methylesterase activity
RPE_RS23345	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RPE_RS23350	COG0835	chemotaxis
RPE_RS23355	COG0840	transmembrane signaling receptor activity
RPE_RS23360	COG0840	transmembrane signaling receptor activity
RPE_RS23365	COG0835	chemotaxis
RPE_RS23370	COG0643	Histidine kinase
RPE_RS23370	COG2198	Histidine kinase
RPE_RS23375	COG0745	RESPONSE REGULATOR receiver
RPE_RS23385	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RPE_RS23390	COG3791	Glutathione-dependent formaldehyde-activating
RPE_RS23395	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RPE_RS23415	COG1131	(ABC) transporter
RPE_RS23435	COG4178	(ABC) transporter
RPE_RS23450	COG0247	lactate metabolic process
RPE_RS23455	COG0277	FAD linked oxidase domain protein
RPE_RS23460	COG0277	FAD linked oxidase domain protein
RPE_RS23480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RPE_RS23485	COG0037	tRNA processing
RPE_RS23495	COG2885	chlorophyll binding
RPE_RS23500	COG2207	Transcriptional regulator
RPE_RS23515	COG5001	Diguanylate cyclase
RPE_RS23520	COG0823	Involved in the tonB-independent uptake of proteins
RPE_RS23555	COG3795	YCII-related domain
RPE_RS23565	COG1028	Short-chain dehydrogenase reductase Sdr
RPE_RS23575	COG0483	inositol monophosphate 1-phosphatase activity
RPE_RS23590	COG3588	fructose-bisphosphate aldolase
RPE_RS23605	COG0126	phosphoglycerate kinase activity
RPE_RS23635	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
RPE_RS23650	COG3795	YCII-related domain
RPE_RS23655	COG4941	Belongs to the sigma-70 factor family
RPE_RS23665	COG2814	Major facilitator Superfamily
RPE_RS23680	COG0826	peptidase U32
RPE_RS23690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RPE_RS23710	COG3655	Transcriptional regulator
RPE_RS23715	COG0312	modulator of DNA gyrase
RPE_RS23735	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
RPE_RS23735	COG1565	acr, cog1565
RPE_RS23740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
RPE_RS23745	COG0109	protoheme IX farnesyltransferase activity
RPE_RS23755	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RPE_RS23770	COG3346	SURF1 family
RPE_RS23780	COG0612	Peptidase, M16
RPE_RS23785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RPE_RS23795	COG0824	Thioesterase
RPE_RS23820	COG2255	four-way junction helicase activity
RPE_RS23830	COG0632	four-way junction helicase activity
RPE_RS23835	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RPE_RS23840	COG0217	transcriptional regulatory protein
RPE_RS23845	COG0840	transmembrane signaling receptor activity
RPE_RS23850	COG1032	radical SAM domain protein
RPE_RS23855	COG1692	metallophosphoesterase
RPE_RS23860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
RPE_RS23865	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPE_RS23870	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RPE_RS23880	COG0356	it plays a direct role in the translocation of protons across the membrane
RPE_RS23900	COG0432	Pfam Uncharacterised protein family UPF0047
RPE_RS23905	COG0477	Major facilitator Superfamily
RPE_RS23915	COG2205	protein histidine kinase activity
RPE_RS23915	COG2198	Histidine kinase
RPE_RS23915	COG0784	Response regulator, receiver
RPE_RS23920	COG0156	8-amino-7-oxononanoate synthase activity
RPE_RS23985	COG0251	oxidation-reduction process
RPE_RS24020	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RPE_RS24025	COG0330	HflC and HflK could
RPE_RS24040	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RPE_RS24045	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RPE_RS24050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RPE_RS24065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RPE_RS24070	COG3577	Aspartyl protease
RPE_RS24075	COG1643	Atp-dependent helicase
RPE_RS24090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPE_RS24090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RPE_RS24095	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RPE_RS24110	COG0058	SHG alpha-glucan phosphorylase activity
RPE_RS24140	COG2884	Cell division ATP-binding protein ftsE
RPE_RS24165	COG0076	glutamate decarboxylase activity
RPE_RS24175	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RPE_RS24180	COG0019	diaminopimelate decarboxylase activity
RPE_RS24190	COG0165	Argininosuccinate lyase
RPE_RS24195	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RPE_RS24215	COG1250	3-hydroxyacyl-CoA dehydrogenase
RPE_RS24220	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
RPE_RS24225	COG2086	electron transfer activity
RPE_RS24245	COG0784	Response regulator, receiver
RPE_RS24245	COG5002	protein histidine kinase activity
RPE_RS24250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RPE_RS24310	COG0366	Alpha amylase catalytic
RPE_RS24335	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RPE_RS24370	COG0717	Belongs to the dCTP deaminase family
RPE_RS24405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RPE_RS24410	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RPE_RS24420	COG0745	RESPONSE REGULATOR receiver
RPE_RS24425	COG0704	Plays a role in the regulation of phosphate uptake
RPE_RS24430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RPE_RS24435	COG0581	inorganic phosphate transmembrane transporter activity
RPE_RS24440	COG0573	inorganic phosphate transmembrane transporter activity
RPE_RS24445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RPE_RS24465	COG2885	chlorophyll binding
RPE_RS24475	COG0326	Molecular chaperone. Has ATPase activity
RPE_RS24495	COG3038	cytochrome b561
RPE_RS24525	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RPE_RS24550	COG0514	ATP-dependent DNA helicase (RecQ)
RPE_RS24580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RPE_RS24590	COG0268	Binds directly to 16S ribosomal RNA
RPE_RS24665	COG3300	MHYT domain
RPE_RS24665	COG5001	Diguanylate cyclase
RPE_RS24690	COG5001	Diguanylate cyclase
RPE_RS24750	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
RPE_RS24795	COG1216	Glycosyl transferase, family 2
RPE_RS24810	COG3300	MHYT domain
RPE_RS24810	COG5001	Diguanylate cyclase