locus-tag	class	description
F11_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F11_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
F11_RS00045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F11_RS00050	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F11_RS00055	COG1137	ATPase activity
F11_RS00090	COG1968	undecaprenyl-diphosphatase activity
F11_RS00105	COG0386	Belongs to the glutathione peroxidase family
F11_RS00110	COG1846	Transcriptional regulator
F11_RS00125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F11_RS00140	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F11_RS00145	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F11_RS00160	COG0583	DNA-binding transcription factor activity
F11_RS00165	COG4235	cytochrome complex assembly
F11_RS00170	COG3088	subunit of a heme lyase
F11_RS00175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F11_RS00180	COG1138	Cytochrome C-type biogenesis protein
F11_RS00185	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
F11_RS00195	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F11_RS00200	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F11_RS00205	COG4133	protoheme IX ABC transporter activity
F11_RS00220	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F11_RS00225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F11_RS00240	COG0488	(ABC) transporter
F11_RS00245	COG1280	lysine exporter protein (LysE YggA)
F11_RS00250	COG4770	biotin carboxylase activity
F11_RS00265	COG4770	biotin carboxylase activity
F11_RS00270	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F11_RS00275	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F11_RS00295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F11_RS00300	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F11_RS00305	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F11_RS00310	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F11_RS00315	COG1657	PFAM Prenyltransferase squalene oxidase
F11_RS00320	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
F11_RS00325	COG1562	ergosterol biosynthetic process
F11_RS00330	COG1562	ergosterol biosynthetic process
F11_RS00335	COG2202	Pas domain
F11_RS00335	COG2205	protein histidine kinase activity
F11_RS00345	COG2267	carboxylic ester hydrolase activity
F11_RS00350	COG1131	(ABC) transporter
F11_RS00360	COG0697	spore germination
F11_RS00370	COG0326	Molecular chaperone. Has ATPase activity
F11_RS00385	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
F11_RS00410	COG0840	transmembrane signaling receptor activity
F11_RS00410	COG5278	phosphoserine phosphatase activity
F11_RS00415	COG0840	transmembrane signaling receptor activity
F11_RS00435	COG1671	Belongs to the UPF0178 family
F11_RS00450	COG0514	ATP-dependent DNA helicase (RecQ)
F11_RS00465	COG1653	transport
F11_RS00470	COG1175	transmembrane transport
F11_RS00475	COG0395	ABC-type sugar transport system, permease component
F11_RS00480	COG3842	ATPase activity
F11_RS00485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS00500	COG2208	phosphoserine phosphatase activity
F11_RS00500	COG2770	Histidine kinase
F11_RS00515	COG3706	GGDEF domain
F11_RS00515	COG5001	Diguanylate cyclase
F11_RS00515	COG4251	negative regulation of phosphorylation
F11_RS00515	COG2203	Gaf domain
F11_RS00520	COG2900	Belongs to the SlyX family
F11_RS00530	COG2373	Large extracellular alpha-helical protein
F11_RS00535	COG4953	penicillin-binding protein 1C
F11_RS00545	COG3267	Type II secretory pathway component ExeA
F11_RS00545	COG3409	Peptidoglycan-binding domain 1 protein
F11_RS00575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F11_RS00595	COG3845	ABC transporter
F11_RS00600	COG2805	Type II/IV secretion system protein
F11_RS00610	COG2203	Gaf domain
F11_RS00610	COG0840	transmembrane signaling receptor activity
F11_RS00625	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F11_RS00625	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F11_RS00640	COG1131	(ABC) transporter
F11_RS00650	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F11_RS00670	COG3437	response regulator, receiver
F11_RS00670	COG0784	Response regulator, receiver
F11_RS00680	COG0438	transferase activity, transferring glycosyl groups
F11_RS00700	COG2358	TRAP transporter, solute receptor (TAXI family
F11_RS00705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F11_RS00720	COG0113	porphobilinogen synthase activity
F11_RS00735	COG1902	pentaerythritol trinitrate reductase activity
F11_RS00745	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F11_RS00755	COG1217	gtp-binding protein TYPA
F11_RS00760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F11_RS00780	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F11_RS00785	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F11_RS00790	COG1309	transcriptional regulator
F11_RS00810	COG1570	exodeoxyribonuclease VII activity
F11_RS00815	COG5425	PFAM Usg family protein
F11_RS00820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F11_RS00825	COG0459	protein refolding
F11_RS00835	COG0659	secondary active sulfate transmembrane transporter activity
F11_RS00875	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F11_RS00880	COG1518	maintenance of DNA repeat elements
F11_RS00895	COG1857	crispr-associated protein
F11_RS00910	COG1203	CRISPR-associated helicase, Cas3
F11_RS00915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F11_RS00925	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F11_RS00930	COG1518	maintenance of DNA repeat elements
F11_RS00930	COG1468	defense response to virus
F11_RS00975	COG1132	(ABC) transporter
F11_RS00975	COG2375	cellular response to nickel ion
F11_RS00980	COG1132	(ABC) transporter
F11_RS00980	COG2375	cellular response to nickel ion
F11_RS00985	COG4771	TonB-dependent receptor
F11_RS00995	COG0534	Mate efflux family protein
F11_RS01040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F11_RS01070	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F11_RS01080	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F11_RS01110	COG1522	sequence-specific DNA binding
F11_RS01115	COG2301	Belongs to the HpcH HpaI aldolase family
F11_RS01135	COG0126	phosphoglycerate kinase activity
F11_RS01155	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F11_RS01175	COG0438	transferase activity, transferring glycosyl groups
F11_RS01180	COG0367	asparagine synthase
F11_RS01205	COG0653	protein targeting
F11_RS01210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F11_RS01235	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F11_RS01245	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F11_RS01245	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F11_RS01255	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F11_RS01260	COG0248	Ppx GppA phosphatase
F11_RS01260	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F11_RS01270	COG1879	ABC-type sugar transport system periplasmic component
F11_RS01275	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS01280	COG1129	ABC transporter
F11_RS01285	COG1070	Carbohydrate kinase
F11_RS01295	COG1063	alcohol dehydrogenase
F11_RS01300	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F11_RS01305	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F11_RS01320	COG4269	membrane
F11_RS01330	COG1966	Carbon starvation protein
F11_RS01335	COG2879	small protein
F11_RS01350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F11_RS01365	COG1573	uracil-dna glycosylase
F11_RS01370	COG0741	lytic transglycosylase activity
F11_RS01370	COG0739	heme binding
F11_RS01370	COG1196	nuclear chromosome segregation
F11_RS01375	COG0521	Mo-molybdopterin cofactor biosynthetic process
F11_RS01390	COG0302	gtp cyclohydrolase
F11_RS01395	COG2076	Multidrug Resistance protein
F11_RS01400	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS01405	COG0183	Belongs to the thiolase family
F11_RS01430	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F11_RS01440	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F11_RS01445	COG1971	Probably functions as a manganese efflux pump
F11_RS01455	COG0028	Belongs to the TPP enzyme family
F11_RS01460	COG1012	belongs to the aldehyde dehydrogenase family
F11_RS01475	COG0656	L-ascorbic acid biosynthetic process
F11_RS01495	COG0776	regulation of translation
F11_RS01500	COG0539	negative regulation of cytoplasmic translation
F11_RS01505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F11_RS01510	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F11_RS01530	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
F11_RS01535	COG1012	belongs to the aldehyde dehydrogenase family
F11_RS01540	COG0519	Catalyzes the synthesis of GMP from XMP
F11_RS01580	COG0298	carbon dioxide binding
F11_RS01585	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F11_RS01590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F11_RS01600	COG2116	formate transmembrane transporter activity
F11_RS01610	COG2414	aldehyde ferredoxin oxidoreductase
F11_RS01615	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F11_RS01620	COG0651	ATP synthesis coupled electron transport
F11_RS01625	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
F11_RS01625	COG3261	NADH dehydrogenase
F11_RS01630	COG0650	Formate hydrogenlyase subunit 4
F11_RS01640	COG4237	Hydrogenase 4 membrane
F11_RS01645	COG0651	ATP synthesis coupled electron transport
F11_RS01650	COG3260	NADH ubiquinone oxidoreductase 20
F11_RS01660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
F11_RS01665	COG3383	formate dehydrogenase (NAD+) activity
F11_RS01670	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F11_RS01675	COG3604	Transcriptional regulator
F11_RS01680	COG2205	protein histidine kinase activity
F11_RS01690	COG0583	DNA-binding transcription factor activity
F11_RS01695	COG0697	spore germination
F11_RS01700	COG0625	glutathione transferase activity
F11_RS01705	COG0783	Belongs to the Dps family
F11_RS01720	COG0442	prolyl-tRNA aminoacylation
F11_RS01735	COG1733	regulation of RNA biosynthetic process
F11_RS01750	COG1203	CRISPR-associated helicase, Cas3
F11_RS01790	COG1518	maintenance of DNA repeat elements
F11_RS01805	COG3012	SEC-C Motif Domain Protein
F11_RS01825	COG0582	viral genome integration into host DNA
F11_RS01830	COG0519	Catalyzes the synthesis of GMP from XMP
F11_RS01835	COG0538	isocitrate dehydrogenase activity
F11_RS01850	COG0235	Class ii aldolase
F11_RS01855	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F11_RS01860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F11_RS01880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F11_RS01905	COG0714	Associated with various cellular activities
F11_RS01925	COG0655	NAD(P)H dehydrogenase (quinone) activity
F11_RS01930	COG0435	Glutathione S-transferase
F11_RS01935	COG1741	Belongs to the pirin family
F11_RS01945	COG3275	phosphorelay sensor kinase activity
F11_RS01965	COG0716	FMN binding
F11_RS01975	COG2814	Major facilitator Superfamily
F11_RS01995	COG0405	Gamma-glutamyltransferase
F11_RS02035	COG1058	Belongs to the CinA family
F11_RS02035	COG1546	Belongs to the CinA family
F11_RS02040	COG0494	nUDIX hydrolase
F11_RS02045	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F11_RS02050	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F11_RS02055	COG0019	diaminopimelate decarboxylase activity
F11_RS02065	COG0165	Argininosuccinate lyase
F11_RS02070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F11_RS02095	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS02100	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F11_RS02120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F11_RS02125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F11_RS02135	COG0359	binds to the 23S rRNA
F11_RS02145	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F11_RS02150	COG0360	Binds together with S18 to 16S ribosomal RNA
F11_RS02155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F11_RS02170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F11_RS02175	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F11_RS02210	COG0300	oxidoreductase activity
F11_RS02215	COG1561	YicC-like family, N-terminal region
F11_RS02220	COG0194	GDP metabolic process
F11_RS02230	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F11_RS02240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F11_RS02245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F11_RS02250	COG1960	acyl-CoA dehydrogenase activity
F11_RS02260	COG2885	chlorophyll binding
F11_RS02260	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F11_RS02265	COG4191	Histidine kinase
F11_RS02265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS02270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS02285	COG0277	FAD linked oxidase domain protein
F11_RS02295	COG0009	L-threonylcarbamoyladenylate synthase
F11_RS02315	COG1355	regulation of microtubule-based process
F11_RS02330	COG1518	maintenance of DNA repeat elements
F11_RS02335	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F11_RS02345	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F11_RS02350	COG0494	nUDIX hydrolase
F11_RS02355	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F11_RS02360	COG3657	addiction module killer protein
F11_RS02390	COG1012	belongs to the aldehyde dehydrogenase family
F11_RS02395	COG3616	Alanine racemase, N-terminal domain
F11_RS02405	COG0560	Phosphoserine phosphatase
F11_RS02405	COG3830	Belongs to the UPF0237 family
F11_RS02410	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F11_RS02415	COG0028	Belongs to the TPP enzyme family
F11_RS02425	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F11_RS02445	COG0768	penicillin binding
F11_RS02450	COG2130	NADP-dependent
F11_RS02455	COG1902	pentaerythritol trinitrate reductase activity
F11_RS02460	COG1764	response to oxidative stress
F11_RS02470	COG0535	radical SAM domain protein
F11_RS02500	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F11_RS02505	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F11_RS02525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F11_RS02530	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
F11_RS02540	COG1233	COG1233 Phytoene dehydrogenase and related
F11_RS02545	COG1562	ergosterol biosynthetic process
F11_RS02555	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F11_RS02560	COG3842	ATPase activity
F11_RS02565	COG2011	ABC-type metal ion transport system permease component
F11_RS02605	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F11_RS02615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F11_RS02620	COG2856	Zn peptidase
F11_RS02630	COG1204	response to ionizing radiation
F11_RS02645	COG0167	dihydroorotate dehydrogenase activity
F11_RS02680	COG2198	Histidine kinase
F11_RS02680	COG0643	Histidine kinase
F11_RS02680	COG0784	Response regulator, receiver
F11_RS02685	COG0745	RESPONSE REGULATOR receiver
F11_RS02690	COG2201	protein-glutamate methylesterase activity
F11_RS02715	COG0484	heat shock protein binding
F11_RS02750	COG0697	spore germination
F11_RS02755	COG2207	Transcriptional regulator
F11_RS02770	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F11_RS02775	COG2204	response regulator
F11_RS02780	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F11_RS02785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F11_RS02795	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F11_RS02800	COG1766	The M ring may be actively involved in energy transduction
F11_RS02805	COG1749	Flagellar hook protein flgE
F11_RS02840	COG3437	response regulator, receiver
F11_RS02840	COG0784	Response regulator, receiver
F11_RS02845	COG0004	ammonium transporteR
F11_RS02850	COG0347	Belongs to the P(II) protein family
F11_RS02860	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F11_RS02880	COG1294	oxidase, subunit
F11_RS02905	COG0493	'glutamate synthase
F11_RS02905	COG0543	2 iron, 2 sulfur cluster binding
F11_RS02910	COG0312	modulator of DNA gyrase
F11_RS02935	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F11_RS02945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F11_RS02950	COG0312	modulator of DNA gyrase
F11_RS02955	COG0840	transmembrane signaling receptor activity
F11_RS02960	COG1597	lipid kinase activity
F11_RS02970	COG0438	transferase activity, transferring glycosyl groups
F11_RS02975	COG1764	response to oxidative stress
F11_RS02980	COG1519	Transferase
F11_RS02985	COG1663	tetraacyldisaccharide 4'-kinase activity
F11_RS03005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F11_RS03010	COG0459	protein refolding
F11_RS03025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS03030	COG0601	transmembrane transport
F11_RS03040	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F11_RS03045	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
F11_RS03065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F11_RS03070	COG0573	inorganic phosphate transmembrane transporter activity
F11_RS03075	COG0581	inorganic phosphate transmembrane transporter activity
F11_RS03080	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F11_RS03090	COG0745	RESPONSE REGULATOR receiver
F11_RS03100	COG2855	membrane
F11_RS03110	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
F11_RS03175	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F11_RS03180	COG1429	ligase activity, forming nitrogen-metal bonds
F11_RS03185	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS03190	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS03210	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F11_RS03215	COG2211	Major facilitator Superfamily
F11_RS03220	COG0644	oxidoreductase
F11_RS03230	COG5001	Diguanylate cyclase
F11_RS03240	COG2176	DNA-directed DNA polymerase activity
F11_RS03250	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F11_RS03255	COG3162	membrane
F11_RS03270	COG2137	regulation of response to DNA damage stimulus
F11_RS03275	COG0842	Transport permease protein
F11_RS03280	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F11_RS03290	COG1496	oxidoreductase activity
F11_RS03300	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F11_RS03315	COG4106	trans-aconitate 2-methyltransferase activity
F11_RS03325	COG0590	tRNA wobble adenosine to inosine editing
F11_RS03330	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
F11_RS03335	COG1187	pseudouridine synthase activity
F11_RS03340	COG0742	ribosomal rna small subunit methyltransferase
F11_RS03350	COG1522	sequence-specific DNA binding
F11_RS03355	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F11_RS03355	COG0506	proline dehydrogenase activity
F11_RS03355	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
F11_RS03365	COG0583	DNA-binding transcription factor activity
F11_RS03370	COG5001	Diguanylate cyclase
F11_RS03370	COG3300	MHYT domain
F11_RS03380	COG1272	protein, Hemolysin III
F11_RS03385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F11_RS03390	COG1278	Cold shock
F11_RS03395	COG3920	Histidine kinase
F11_RS03400	COG0784	Response regulator, receiver
F11_RS03405	COG3850	Histidine kinase
F11_RS03405	COG4999	Histidine kinase
F11_RS03405	COG3437	response regulator, receiver
F11_RS03405	COG2205	protein histidine kinase activity
F11_RS03410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
F11_RS03415	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
F11_RS03500	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F11_RS03525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F11_RS03530	COG0215	cysteine-tRNA ligase activity
F11_RS03535	COG3852	Histidine kinase
F11_RS03545	COG2204	response regulator
F11_RS03560	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F11_RS03565	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F11_RS03575	COG0657	acetylesterase activity
F11_RS03595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F11_RS03600	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F11_RS03605	COG4149	molybdate abc transporter
F11_RS03610	COG0725	ABC transporter, periplasmic molybdate-binding protein
F11_RS03615	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
F11_RS03620	COG2962	Rard protein
F11_RS03625	COG0271	Belongs to the BolA IbaG family
F11_RS03630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F11_RS03635	COG0047	phosphoribosylformylglycinamidine synthase activity
F11_RS03645	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F11_RS03670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F11_RS03675	COG2932	Transcriptional regulator
F11_RS03695	COG3806	Anti-sigma factor
F11_RS03700	COG1595	DNA-templated transcription, initiation
F11_RS03715	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F11_RS03720	COG2211	Major facilitator Superfamily
F11_RS03735	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS03750	COG2003	Belongs to the UPF0758 family
F11_RS03755	COG0024	Methionine aminopeptidase
F11_RS03765	COG1489	DNA binding
F11_RS03770	COG4106	trans-aconitate 2-methyltransferase activity
F11_RS03775	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F11_RS03795	COG3920	Histidine kinase
F11_RS03795	COG2202	Pas domain
F11_RS03800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F11_RS03815	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F11_RS03825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F11_RS03830	COG0124	histidyl-tRNA synthetase
F11_RS03835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F11_RS03840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F11_RS03845	COG2890	protein-(glutamine-N5) methyltransferase activity
F11_RS03855	COG0542	response to heat
F11_RS03870	COG1253	flavin adenine dinucleotide binding
F11_RS03885	COG0667	Aldo Keto reductase
F11_RS03900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F11_RS03910	COG0316	Belongs to the HesB IscA family
F11_RS03925	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
F11_RS03940	COG1840	ABC-type Fe3 transport system, periplasmic component
F11_RS03945	COG0739	heme binding
F11_RS03985	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS04010	COG0277	FAD linked oxidase domain protein
F11_RS04015	COG1464	Belongs to the NlpA lipoprotein family
F11_RS04020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS04025	COG4597	amino acid ABC transporter
F11_RS04030	COG0765	amino acid transport
F11_RS04050	COG0583	DNA-binding transcription factor activity
F11_RS04055	COG0626	cystathionine gamma-synthase activity
F11_RS04060	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F11_RS04065	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F11_RS04070	COG2011	ABC-type metal ion transport system permease component
F11_RS04090	COG1045	serine acetyltransferase
F11_RS04095	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS04105	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F11_RS04115	COG2814	Major facilitator Superfamily
F11_RS04120	COG0156	8-amino-7-oxononanoate synthase activity
F11_RS04130	COG0601	transmembrane transport
F11_RS04135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS04140	COG0444	Belongs to the ABC transporter superfamily
F11_RS04145	COG4608	Belongs to the ABC transporter superfamily
F11_RS04165	COG3838	Conjugal transfer protein Trbc
F11_RS04170	COG4962	Type ii secretion system protein e
F11_RS04240	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F11_RS04260	COG3328	transposase activity
F11_RS04300	COG1518	maintenance of DNA repeat elements
F11_RS04305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F11_RS04330	COG2814	Major facilitator Superfamily
F11_RS04345	COG1132	(ABC) transporter
F11_RS04430	COG2814	Major facilitator Superfamily
F11_RS04435	COG1566	PFAM secretion protein HlyD family protein
F11_RS04445	COG1846	Transcriptional regulator
F11_RS04455	COG1132	(ABC) transporter
F11_RS04455	COG2375	cellular response to nickel ion
F11_RS04465	COG4771	TonB-dependent receptor
F11_RS04530	COG0488	(ABC) transporter
F11_RS04535	COG4977	sequence-specific DNA binding
F11_RS04535	COG1917	Cupin 2, conserved barrel domain protein
F11_RS04540	COG4771	TonB-dependent receptor
F11_RS04545	COG2375	cellular response to nickel ion
F11_RS04545	COG1132	(ABC) transporter
F11_RS04550	COG1132	(ABC) transporter
F11_RS04555	COG1595	DNA-templated transcription, initiation
F11_RS04565	COG4774	siderophore transport
F11_RS04575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS04615	COG1396	sequence-specific DNA binding
F11_RS04635	COG1358	cellular component organization or biogenesis
F11_RS04655	COG1882	Formate acetyltransferase
F11_RS04685	COG4869	propanediol catabolic process
F11_RS04700	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
F11_RS04720	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F11_RS04725	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F11_RS04730	COG2972	Histidine kinase
F11_RS04735	COG2197	response regulator
F11_RS04740	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F11_RS04770	COG0438	transferase activity, transferring glycosyl groups
F11_RS04780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F11_RS04785	COG0375	protein maturation
F11_RS04795	COG1454	alcohol dehydrogenase
F11_RS04800	COG1012	belongs to the aldehyde dehydrogenase family
F11_RS04805	COG3284	Transcriptional regulator
F11_RS04815	COG1442	glycosyl transferase family 8
F11_RS04830	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
F11_RS04835	COG0463	Glycosyl transferase, family 2
F11_RS04835	COG1216	Glycosyl transferase, family 2
F11_RS04840	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F11_RS04845	COG0497	DNA recombination
F11_RS04850	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F11_RS04855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F11_RS04865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F11_RS04870	COG0849	cell division
F11_RS04875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F11_RS04880	COG1181	Belongs to the D-alanine--D-alanine ligase family
F11_RS04885	COG0812	UDP-N-acetylmuramate dehydrogenase activity
F11_RS04890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F11_RS04895	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F11_RS04905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
F11_RS04910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F11_RS04920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F11_RS04925	COG0768	penicillin binding
F11_RS04935	COG0275	rRNA processing
F11_RS04940	COG2001	Belongs to the MraZ family
F11_RS04945	COG3023	N-Acetylmuramoyl-L-alanine amidase
F11_RS04950	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F11_RS04995	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
F11_RS04995	COG3608	succinylglutamate desuccinylase aspartoacylase
F11_RS05000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F11_RS05005	COG1605	Chorismate mutase
F11_RS05005	COG0287	Prephenate dehydrogenase
F11_RS05025	COG2161	toxin-antitoxin pair type II binding
F11_RS05060	COG0601	transmembrane transport
F11_RS05070	COG4172	Belongs to the ABC transporter superfamily
F11_RS05075	COG0154	amidase activity
F11_RS05080	COG1473	amidohydrolase
F11_RS05085	COG2203	Gaf domain
F11_RS05085	COG5001	Diguanylate cyclase
F11_RS05085	COG3706	GGDEF domain
F11_RS05085	COG4251	negative regulation of phosphorylation
F11_RS05105	COG1744	ABC transporter substrate-binding protein PnrA-like
F11_RS05130	COG0535	radical SAM domain protein
F11_RS05135	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F11_RS05145	COG5554	nitrogen fixation
F11_RS05150	COG5554	nitrogen fixation
F11_RS05165	COG1126	abc transporter atp-binding protein
F11_RS05170	COG0765	amino acid transport
F11_RS05175	COG4597	amino acid ABC transporter
F11_RS05180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS05185	COG0463	Glycosyl transferase, family 2
F11_RS05215	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS05220	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS05225	COG0488	(ABC) transporter
F11_RS05235	COG1177	transmembrane transport
F11_RS05240	COG1176	ABC-type spermidine putrescine transport system, permease component I
F11_RS05245	COG3842	ATPase activity
F11_RS05255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F11_RS05260	COG3474	cytochrome
F11_RS05290	COG0789	Transcriptional regulator
F11_RS05295	COG2217	Heavy metal translocating P-type atpase
F11_RS05305	COG2207	Transcriptional regulator
F11_RS05310	COG0531	amino acid
F11_RS05320	COG4303	Ethanolamine ammonia lyase large subunit
F11_RS05325	COG3685	Protein conserved in bacteria
F11_RS05330	COG2200	EAL domain
F11_RS05330	COG2199	diguanylate cyclase activity
F11_RS05330	COG2203	Gaf domain
F11_RS05340	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F11_RS05345	COG3454	Phosphonate metabolism
F11_RS05365	COG0583	DNA-binding transcription factor activity
F11_RS05370	COG3750	Belongs to the UPF0335 family
F11_RS05375	COG0828	Belongs to the bacterial ribosomal protein bS21 family
F11_RS05380	COG0242	peptide deformylase activity
F11_RS05415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F11_RS05420	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F11_RS05430	COG0840	transmembrane signaling receptor activity
F11_RS05445	COG0604	alcohol dehydrogenase
F11_RS05445	COG3321	synthase
F11_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS05455	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS05465	COG0667	Aldo Keto reductase
F11_RS05490	COG3549	Plasmid maintenance system killer
F11_RS05495	COG3093	addiction module antidote protein HigA
F11_RS05500	COG3842	ATPase activity
F11_RS05510	COG1104	cysteine desulfurase activity
F11_RS05530	COG0254	rRNA binding
F11_RS05550	COG0483	inositol monophosphate 1-phosphatase activity
F11_RS05555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F11_RS05560	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
F11_RS05570	COG0352	thiamine-phosphate diphosphorylase activity
F11_RS05590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F11_RS05595	COG1692	metallophosphoesterase
F11_RS05600	COG0217	transcriptional regulatory protein
F11_RS05605	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
F11_RS05610	COG0632	four-way junction helicase activity
F11_RS05615	COG2255	four-way junction helicase activity
F11_RS05620	COG0824	Thioesterase
F11_RS05640	COG0823	Involved in the tonB-independent uptake of proteins
F11_RS05645	COG2885	chlorophyll binding
F11_RS05655	COG0037	tRNA processing
F11_RS05665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F11_RS05670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F11_RS05680	COG0352	thiamine-phosphate diphosphorylase activity
F11_RS05680	COG0351	phosphomethylpyrimidine kinase
F11_RS05695	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
F11_RS05700	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F11_RS05715	COG0840	transmembrane signaling receptor activity
F11_RS05725	COG0564	pseudouridine synthase activity
F11_RS05740	COG0477	Major facilitator Superfamily
F11_RS05760	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F11_RS05770	COG5265	(ABC) transporter
F11_RS05775	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F11_RS05790	COG0277	FAD linked oxidase domain protein
F11_RS05795	COG3620	sequence-specific DNA binding
F11_RS05820	COG0004	ammonium transporteR
F11_RS05825	COG0347	Belongs to the P(II) protein family
F11_RS05840	COG0556	nucleotide-excision repair
F11_RS05850	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F11_RS05855	COG0436	Aminotransferase
F11_RS05865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F11_RS05870	COG1120	ATPase activity
F11_RS05880	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F11_RS05890	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F11_RS05900	COG3135	benzoate transporter
F11_RS05905	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F11_RS05910	COG0156	8-amino-7-oxononanoate synthase activity
F11_RS05915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F11_RS05945	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F11_RS05950	COG1518	maintenance of DNA repeat elements
F11_RS05975	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
F11_RS05980	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
F11_RS05985	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
F11_RS05990	COG2205	protein histidine kinase activity
F11_RS05995	COG0745	RESPONSE REGULATOR receiver
F11_RS06000	COG0840	transmembrane signaling receptor activity
F11_RS06020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F11_RS06035	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F11_RS06050	COG2204	response regulator
F11_RS06060	COG1959	2 iron, 2 sulfur cluster binding
F11_RS06065	COG1522	sequence-specific DNA binding
F11_RS06075	COG0251	oxidation-reduction process
F11_RS06080	COG3237	CsbD-like
F11_RS06090	COG0840	transmembrane signaling receptor activity
F11_RS06095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F11_RS06100	COG1349	DNA-binding transcription factor activity
F11_RS06105	COG2223	nitrite transmembrane transporter activity
F11_RS06110	COG0552	protein localization to endoplasmic reticulum
F11_RS06115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F11_RS06120	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F11_RS06125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F11_RS06130	COG0228	four-way junction DNA binding
F11_RS06135	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F11_RS06140	COG0336	Belongs to the RNA methyltransferase TrmD family
F11_RS06145	COG0335	large ribosomal subunit rRNA binding
F11_RS06150	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F11_RS06155	COG0066	3-isopropylmalate dehydratase activity
F11_RS06160	COG0473	3-isopropylmalate dehydrogenase activity
F11_RS06175	COG1342	Belongs to the UPF0251 family
F11_RS06185	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F11_RS06200	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
F11_RS06210	COG2030	dehydratase
F11_RS06215	COG2009	succinate dehydrogenase
F11_RS06245	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F11_RS06255	COG0039	L-malate dehydrogenase activity
F11_RS06260	COG0045	succinate-CoA ligase (ADP-forming) activity
F11_RS06275	COG0508	dehydrogenase complex catalyzes the overall conversion of
F11_RS06280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F11_RS06295	COG1842	Phage shock protein A
F11_RS06300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
F11_RS06305	COG4974	Belongs to the 'phage' integrase family
F11_RS06355	COG1051	belongs to the nudix hydrolase family
F11_RS06365	COG0793	Belongs to the peptidase S41A family
F11_RS06370	COG4942	peptidase
F11_RS06375	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
F11_RS06380	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F11_RS06385	COG0799	negative regulation of ribosome biogenesis
F11_RS06390	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F11_RS06395	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F11_RS06400	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
F11_RS06405	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F11_RS06410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F11_RS06415	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F11_RS06470	COG0174	glutamine synthetase
F11_RS06475	COG0174	glutamine synthetase
F11_RS06510	COG3842	ATPase activity
F11_RS06515	COG1175	transmembrane transport
F11_RS06530	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS06535	COG1349	DNA-binding transcription factor activity
F11_RS06540	COG0434	BtpA family
F11_RS06545	COG1070	Carbohydrate kinase
F11_RS06550	COG0546	phosphoglycolate phosphatase activity
F11_RS06570	COG3447	MASE1 domain protein
F11_RS06570	COG5001	Diguanylate cyclase
F11_RS06570	COG5002	protein histidine kinase activity
F11_RS06575	COG2267	carboxylic ester hydrolase activity
F11_RS06630	COG3005	denitrification pathway
F11_RS06640	COG4249	Peptidase C14 caspase catalytic subunit p20
F11_RS06640	COG2319	Wd-40 repeat
F11_RS06655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F11_RS06670	COG1136	(ABC) transporter
F11_RS06680	COG0840	transmembrane signaling receptor activity
F11_RS06685	COG2188	Transcriptional regulator
F11_RS06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS06695	COG0765	amino acid transport
F11_RS06700	COG0765	amino acid transport
F11_RS06710	COG0277	FAD linked oxidase domain protein
F11_RS06720	COG2986	histidine ammonia-lyase
F11_RS06730	COG1228	amidohydrolase
F11_RS06735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
F11_RS06755	COG1960	acyl-CoA dehydrogenase activity
F11_RS06760	COG1024	Enoyl-CoA hydratase
F11_RS06760	COG1250	3-hydroxyacyl-CoA dehydrogenase
F11_RS06765	COG0183	Belongs to the thiolase family
F11_RS06770	COG0789	Transcriptional regulator
F11_RS06775	COG0318	PFAM AMP-dependent synthetase and ligase
F11_RS06780	COG2067	long-chain fatty acid transport protein
F11_RS06870	COG1122	ATPase activity
F11_RS06875	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
F11_RS06880	COG1268	BioY protein
F11_RS06885	COG0698	ribose 5-phosphate isomerase
F11_RS06890	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS06905	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS06915	COG2376	Dihydroxyacetone kinase
F11_RS06920	COG1461	Dihydroxyacetone kinase
F11_RS06945	COG1802	Transcriptional regulator
F11_RS06950	COG0730	response to heat
F11_RS06985	COG3685	Protein conserved in bacteria
F11_RS06990	COG0753	catalase activity
F11_RS06995	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F11_RS07000	COG0149	triose-phosphate isomerase activity
F11_RS07005	COG0698	ribose 5-phosphate isomerase
F11_RS07010	COG1461	Dihydroxyacetone kinase
F11_RS07015	COG2376	Dihydroxyacetone kinase
F11_RS07025	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS07030	COG1129	ABC transporter
F11_RS07045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F11_RS07100	COG0857	belongs to the CobB CobQ family
F11_RS07100	COG0280	phosphate acetyltransferase
F11_RS07105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F11_RS07110	COG0183	Belongs to the thiolase family
F11_RS07115	COG2031	fatty acid transporter
F11_RS07120	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F11_RS07125	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F11_RS07130	COG3852	Histidine kinase
F11_RS07135	COG2204	response regulator
F11_RS07200	COG0745	RESPONSE REGULATOR receiver
F11_RS07205	COG0643	Histidine kinase
F11_RS07205	COG2198	Histidine kinase
F11_RS07210	COG0835	chemotaxis
F11_RS07215	COG0840	transmembrane signaling receptor activity
F11_RS07220	COG0835	chemotaxis
F11_RS07230	COG0840	transmembrane signaling receptor activity
F11_RS07235	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F11_RS07240	COG2201	protein-glutamate methylesterase activity
F11_RS07245	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
F11_RS07255	COG1620	l-lactate permease
F11_RS07270	COG1139	Iron-sulfur cluster binding protein
F11_RS07275	COG0247	lactate metabolic process
F11_RS07280	COG2186	Transcriptional regulator
F11_RS07295	COG3634	alkyl hydroperoxide reductase activity
F11_RS07310	COG0651	ATP synthesis coupled electron transport
F11_RS07315	COG0650	Formate hydrogenlyase subunit 4
F11_RS07320	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F11_RS07330	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F11_RS07380	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F11_RS07385	COG2204	response regulator
F11_RS07390	COG4191	Histidine kinase
F11_RS07395	COG1301	dicarboxylic acid transport
F11_RS07430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F11_RS07430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F11_RS07455	COG0798	PFAM Bile acid sodium symporter
F11_RS07460	COG0640	Transcriptional regulator
F11_RS07515	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F11_RS07520	COG2207	Transcriptional regulator
F11_RS07540	COG0583	DNA-binding transcription factor activity
F11_RS07545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F11_RS07570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
F11_RS07585	COG2851	Citrate transporter
F11_RS07590	COG2824	Alkylphosphonate utilization operon protein PhnA
F11_RS07620	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F11_RS07625	COG0367	asparagine synthase
F11_RS07650	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F11_RS07660	COG0489	protein tyrosine kinase activity
F11_RS07675	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F11_RS07690	COG0438	transferase activity, transferring glycosyl groups
F11_RS07720	COG2823	Periplasmic or secreted lipoprotein
F11_RS07730	COG1064	alcohol dehydrogenase
F11_RS07735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
F11_RS07740	COG1984	allophanate hydrolase subunit 2
F11_RS07745	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
F11_RS07755	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F11_RS07820	COG1278	Cold shock
F11_RS07825	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F11_RS07840	COG0494	nUDIX hydrolase
F11_RS07845	COG1192	Involved in chromosome partitioning
F11_RS07850	COG0488	(ABC) transporter
F11_RS07870	COG0646	methionine synthase
F11_RS07870	COG1410	methionine synthase
F11_RS07895	COG0210	DNA helicase
F11_RS07910	COG3585	molybdate ion transport
F11_RS07935	COG3300	MHYT domain
F11_RS07935	COG5001	Diguanylate cyclase
F11_RS07950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F11_RS07950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F11_RS07965	COG0544	peptidyl-prolyl cis-trans isomerase activity
F11_RS07970	COG0740	serine-type endopeptidase activity
F11_RS07975	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F11_RS07985	COG0776	regulation of translation
F11_RS08005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F11_RS08010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F11_RS08015	COG0649	NAD binding
F11_RS08020	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F11_RS08030	COG1034	ATP synthesis coupled electron transport
F11_RS08035	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F11_RS08040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F11_RS08050	COG0713	ATP synthesis coupled electron transport
F11_RS08065	COG1007	ATP synthesis coupled electron transport
F11_RS08075	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F11_RS08085	COG0346	lactoylglutathione lyase activity
F11_RS08105	COG0442	prolyl-tRNA aminoacylation
F11_RS08120	COG1136	(ABC) transporter
F11_RS08155	COG0052	Belongs to the universal ribosomal protein uS2 family
F11_RS08160	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F11_RS08165	COG0528	UMP kinase activity
F11_RS08175	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F11_RS08185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F11_RS08190	COG0750	zinc metalloprotease
F11_RS08195	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F11_RS08205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F11_RS08210	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F11_RS08215	COG3494	Protein of unknown function (DUF1009)
F11_RS08220	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F11_RS08225	COG0372	Belongs to the citrate synthase family
F11_RS08230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F11_RS08245	COG0366	Alpha amylase catalytic
F11_RS08250	COG0366	Alpha amylase catalytic
F11_RS08260	COG1640	4-alpha-glucanotransferase
F11_RS08265	COG1196	nuclear chromosome segregation
F11_RS08265	COG3264	Mechanosensitive ion channel
F11_RS08280	COG0523	cobalamin synthesis protein
F11_RS08285	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F11_RS08290	COG0626	cystathionine gamma-synthase activity
F11_RS08300	COG2897	thiosulfate sulfurtransferase activity
F11_RS08330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F11_RS08385	COG0651	ATP synthesis coupled electron transport
F11_RS08395	COG0651	ATP synthesis coupled electron transport
F11_RS08400	COG0651	ATP synthesis coupled electron transport
F11_RS08405	COG1006	Multisubunit Na H antiporter MnhC subunit
F11_RS08420	COG1320	monovalent cation:proton antiporter activity
F11_RS08435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F11_RS08440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F11_RS08490	COG0477	Major facilitator Superfamily
F11_RS08505	COG0784	Response regulator, receiver
F11_RS08520	COG2814	Major facilitator Superfamily
F11_RS08525	COG0318	PFAM AMP-dependent synthetase and ligase
F11_RS08530	COG2200	EAL domain
F11_RS08560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F11_RS08565	COG0416	fatty acid biosynthetic process
F11_RS08570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F11_RS08575	COG0776	regulation of translation
F11_RS08610	COG1324	tolerance protein
F11_RS08615	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F11_RS08615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
F11_RS08645	COG2204	response regulator
F11_RS08650	COG0569	domain protein
F11_RS08655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F11_RS08660	COG0546	phosphoglycolate phosphatase activity
F11_RS08665	COG1923	regulation of RNA biosynthetic process
F11_RS08670	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F11_RS08680	COG0483	inositol monophosphate 1-phosphatase activity
F11_RS08695	COG3956	TIGRFAM MazG family protein
F11_RS08705	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F11_RS08740	COG0321	lipoyl(octanoyl) transferase activity
F11_RS08740	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
F11_RS08745	COG0084	hydrolase, TatD family'
F11_RS08750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F11_RS08760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F11_RS08765	COG1686	Belongs to the peptidase S11 family
F11_RS08775	COG2951	lytic endotransglycosylase activity
F11_RS08800	COG0251	oxidation-reduction process
F11_RS08820	COG2391	methyltransferase activity
F11_RS08835	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F11_RS08840	COG1607	acyl-coa hydrolase
F11_RS08870	COG3338	carbonate dehydratase activity
F11_RS08875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F11_RS08880	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F11_RS08885	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F11_RS08965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F11_RS08970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F11_RS08975	COG0629	single-stranded DNA binding
F11_RS09010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F11_RS09035	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F11_RS09065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F11_RS09070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F11_RS09075	COG1862	Preprotein translocase
F11_RS09090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F11_RS09095	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F11_RS09100	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F11_RS09105	COG0805	protein transport
F11_RS09110	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F11_RS09115	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F11_RS09120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F11_RS09125	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F11_RS09130	COG1994	Peptidase M50
F11_RS09135	COG1472	Belongs to the glycosyl hydrolase 3 family
F11_RS09145	COG0018	arginyl-trna synthetase
F11_RS09150	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F11_RS09155	COG0316	Belongs to the HesB IscA family
F11_RS09160	COG2032	superoxide dismutase activity
F11_RS09180	COG0129	dihydroxy-acid dehydratase activity
F11_RS09185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F11_RS09200	COG0842	Transport permease protein
F11_RS09205	COG0842	Transport permease protein
F11_RS09210	COG1131	(ABC) transporter
F11_RS09215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS09230	COG0525	valine-tRNA ligase activity
F11_RS09240	COG1538	Outer membrane efflux protein
F11_RS09245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F11_RS09275	COG1968	undecaprenyl-diphosphatase activity
F11_RS09315	COG1234	tRNA 3'-trailer cleavage
F11_RS09325	COG1473	amidohydrolase
F11_RS09340	COG3243	poly(R)-hydroxyalkanoic acid synthase
F11_RS09350	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F11_RS09360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F11_RS09365	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F11_RS09375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F11_RS09375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F11_RS09385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F11_RS09385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F11_RS09390	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F11_RS09395	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F11_RS09400	COG0698	ribose 5-phosphate isomerase
F11_RS09405	COG4957	zinc ion binding
F11_RS09420	COG0302	gtp cyclohydrolase
F11_RS09430	COG1024	Enoyl-CoA hydratase
F11_RS09435	COG1960	acyl-CoA dehydrogenase activity
F11_RS09445	COG0113	porphobilinogen synthase activity
F11_RS09475	COG1360	Flagellar Motor Protein
F11_RS09485	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
F11_RS09490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F11_RS09500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F11_RS09505	COG1381	Involved in DNA repair and RecF pathway recombination
F11_RS09515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F11_RS09520	COG0571	ribonuclease III activity
F11_RS09525	COG0681	Belongs to the peptidase S26 family
F11_RS09530	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F11_RS09545	COG1758	RNA polymerase activity
F11_RS09550	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F11_RS09560	COG1573	uracil-dna glycosylase
F11_RS09575	COG0386	Belongs to the glutathione peroxidase family
F11_RS09580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F11_RS09585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F11_RS09590	COG0739	heme binding
F11_RS09590	COG0741	lytic transglycosylase activity
F11_RS09590	COG1196	nuclear chromosome segregation
F11_RS09600	COG0739	heme binding
F11_RS09605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
F11_RS09610	COG1546	Belongs to the CinA family
F11_RS09635	COG4251	negative regulation of phosphorylation
F11_RS09645	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
F11_RS09650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F11_RS09655	COG0508	dehydrogenase complex catalyzes the overall conversion of
F11_RS09660	COG0508	dehydrogenase complex catalyzes the overall conversion of
F11_RS09660	COG0022	dehydrogenase e1 component
F11_RS09665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F11_RS09675	COG0598	Magnesium transport protein CorA
F11_RS09680	COG2205	protein histidine kinase activity
F11_RS09685	COG0148	phosphopyruvate hydratase activity
F11_RS09690	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F11_RS09695	COG0504	CTP synthase activity
F11_RS09705	COG0149	triose-phosphate isomerase activity
F11_RS09715	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F11_RS09730	COG2217	Heavy metal translocating P-type atpase
F11_RS09740	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F11_RS09745	COG0134	indole-3-glycerol-phosphate synthase activity
F11_RS09750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
F11_RS09755	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F11_RS09760	COG1522	sequence-specific DNA binding
F11_RS09765	COG0840	transmembrane signaling receptor activity
F11_RS09775	COG1079	Belongs to the binding-protein-dependent transport system permease family
F11_RS09780	COG4603	Belongs to the binding-protein-dependent transport system permease family
F11_RS09785	COG3845	ABC transporter
F11_RS09790	COG0659	secondary active sulfate transmembrane transporter activity
F11_RS09810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F11_RS09835	COG1278	Cold shock
F11_RS09840	COG0513	Belongs to the DEAD box helicase family
F11_RS09855	COG0601	transmembrane transport
F11_RS09860	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS09870	COG4608	Belongs to the ABC transporter superfamily
F11_RS09885	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F11_RS09900	COG0427	acetyl-CoA hydrolase
F11_RS09905	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F11_RS09910	COG0175	sulfate reduction
F11_RS09920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F11_RS09930	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F11_RS09930	COG1648	precorrin-2 dehydrogenase activity
F11_RS09940	COG2197	response regulator
F11_RS09955	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F11_RS09975	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
F11_RS09980	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F11_RS09995	COG0183	Belongs to the thiolase family
F11_RS10005	COG1960	acyl-CoA dehydrogenase activity
F11_RS10020	COG2207	Transcriptional regulator
F11_RS10050	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F11_RS10055	COG0517	IMP dehydrogenase activity
F11_RS10055	COG0516	GMP reductase activity
F11_RS10060	COG0602	queuosine metabolic process
F11_RS10080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F11_RS10085	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F11_RS10115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F11_RS10115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
F11_RS10120	COG1105	Belongs to the carbohydrate kinase PfkB family
F11_RS10125	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
F11_RS10125	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F11_RS10130	COG1609	Transcriptional regulator
F11_RS10160	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
F11_RS10200	COG1363	Peptidase, m42
F11_RS10205	COG0189	ligase activity
F11_RS10205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F11_RS10210	COG0367	asparagine synthase
F11_RS10235	COG0789	Transcriptional regulator
F11_RS10240	COG2239	Acts as a magnesium transporter
F11_RS10250	COG0321	lipoyl(octanoyl) transferase activity
F11_RS10260	COG1850	ribulose-bisphosphate carboxylase activity
F11_RS10270	COG0662	Cupin 2, conserved barrel domain protein
F11_RS10285	COG1032	radical SAM domain protein
F11_RS10290	COG0583	DNA-binding transcription factor activity
F11_RS10295	COG1960	acyl-CoA dehydrogenase activity
F11_RS10300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F11_RS10310	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F11_RS10315	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F11_RS10320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F11_RS10330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS10340	COG0747	negative chemotaxis
F11_RS10365	COG1598	PFAM Uncharacterised protein family UPF0150
F11_RS10390	COG0840	transmembrane signaling receptor activity
F11_RS10395	COG0482	sulfurtransferase activity
F11_RS10400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F11_RS10415	COG1959	2 iron, 2 sulfur cluster binding
F11_RS10420	COG1045	serine acetyltransferase
F11_RS10425	COG2945	thiolester hydrolase activity
F11_RS10430	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F11_RS10435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F11_RS10445	COG0306	phosphate transporter
F11_RS10465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F11_RS10480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F11_RS10505	COG1176	ABC-type spermidine putrescine transport system, permease component I
F11_RS10515	COG3842	ATPase activity
F11_RS10525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS10530	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F11_RS10540	COG0163	prenyltransferase activity
F11_RS10555	COG0288	reversible hydration of carbon dioxide
F11_RS10560	COG1763	Mo-molybdopterin cofactor biosynthetic process
F11_RS10570	COG1418	mRNA catabolic process
F11_RS10575	COG0277	FAD linked oxidase domain protein
F11_RS10575	COG0247	lactate metabolic process
F11_RS10605	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F11_RS10615	COG1803	Methylglyoxal synthase
F11_RS10625	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F11_RS10635	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F11_RS10640	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F11_RS10665	COG0174	glutamine synthetase
F11_RS10685	COG3045	CreA protein
F11_RS10700	COG0347	Belongs to the P(II) protein family
F11_RS10715	COG0765	amino acid transport
F11_RS10720	COG0765	amino acid transport
F11_RS10725	COG1126	abc transporter atp-binding protein
F11_RS10745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F11_RS10755	COG1674	ftsk spoiiie
F11_RS10770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F11_RS10775	COG0730	response to heat
F11_RS10785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F11_RS10790	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F11_RS10805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F11_RS10810	COG2205	protein histidine kinase activity
F11_RS10810	COG0784	Response regulator, receiver
F11_RS10810	COG2198	Histidine kinase
F11_RS10835	COG1686	Belongs to the peptidase S11 family
F11_RS10845	COG0033	Phosphoglucomutase
F11_RS10850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F11_RS10855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F11_RS10865	COG0243	molybdopterin cofactor binding
F11_RS10880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F11_RS10895	COG0179	Fumarylacetoacetate (FAA) hydrolase
F11_RS10900	COG4221	oxidoreductase activity
F11_RS10910	COG0114	fumarate hydratase activity
F11_RS10915	COG1280	lysine exporter protein (LysE YggA)
F11_RS10950	COG2943	transferase activity, transferring hexosyl groups
F11_RS10960	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F11_RS11005	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
F11_RS11010	COG3811	Belongs to the UPF0386 family
F11_RS11030	COG0860	N-Acetylmuramoyl-L-alanine amidase
F11_RS11035	COG1530	ribonuclease E activity
F11_RS11050	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F11_RS11055	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F11_RS11065	COG0848	biopolymer transport protein
F11_RS11070	COG0811	peptide transport
F11_RS11075	COG1024	Enoyl-CoA hydratase
F11_RS11095	COG0248	Ppx GppA phosphatase
F11_RS11100	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F11_RS11115	COG0628	permease
F11_RS11120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F11_RS11130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F11_RS11135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F11_RS11140	COG0105	UTP biosynthetic process
F11_RS11145	COG0488	(ABC) transporter
F11_RS11150	COG0683	leucine binding
F11_RS11160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F11_RS11165	COG4608	Belongs to the ABC transporter superfamily
F11_RS11175	COG0601	transmembrane transport
F11_RS11190	COG2197	response regulator
F11_RS11195	COG2267	carboxylic ester hydrolase activity
F11_RS11225	COG3335	DDE superfamily endonuclease
F11_RS11235	COG3328	transposase activity
F11_RS11240	COG3328	transposase activity
F11_RS11245	COG1022	Amp-dependent synthetase and ligase
F11_RS11255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F11_RS11260	COG2030	dehydratase
F11_RS11275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F11_RS11280	COG1720	tRNA m6t6A37 methyltransferase activity
F11_RS11300	COG0330	HflC and HflK could
F11_RS11310	COG0489	protein tyrosine kinase activity
F11_RS11355	COG0457	Tetratricopeptide repeat
F11_RS11360	COG0583	DNA-binding transcription factor activity
F11_RS11365	COG0583	DNA-binding transcription factor activity
F11_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS11385	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
F11_RS11390	COG0322	excinuclease ABC activity
F11_RS11395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F11_RS11400	COG0303	'Molybdopterin
F11_RS11405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F11_RS11410	COG1846	Transcriptional regulator
F11_RS11415	COG0745	RESPONSE REGULATOR receiver
F11_RS11430	COG3706	GGDEF domain
F11_RS11460	COG4565	transcriptional regulatory protein
F11_RS11475	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
F11_RS11475	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F11_RS11485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
F11_RS11490	COG1024	Enoyl-CoA hydratase
F11_RS11510	COG0058	SHG alpha-glucan phosphorylase activity
F11_RS11515	COG0297	glycogen (starch) synthase activity
F11_RS11520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
F11_RS11545	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS11565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
F11_RS11570	COG3909	cytochrome
F11_RS11575	COG0583	DNA-binding transcription factor activity
F11_RS11610	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
F11_RS11615	COG0644	oxidoreductase
F11_RS11620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F11_RS11625	COG2086	electron transfer activity
F11_RS11650	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
F11_RS11655	COG1124	(ABC) transporter
F11_RS11660	COG0444	Belongs to the ABC transporter superfamily
F11_RS11665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS11670	COG0601	transmembrane transport
F11_RS11675	COG0747	negative chemotaxis
F11_RS11700	COG3383	formate dehydrogenase (NAD+) activity
F11_RS11710	COG1433	Dinitrogenase iron-molybdenum cofactor
F11_RS11715	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS11720	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS11735	COG0175	sulfate reduction
F11_RS11745	COG1864	DNA RNA non-specific endonuclease
F11_RS11745	COG3591	Belongs to the peptidase S1B family
F11_RS11760	COG0366	Alpha amylase catalytic
F11_RS11765	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F11_RS11770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F11_RS11775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F11_RS11785	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS11790	COG1172	Belongs to the binding-protein-dependent transport system permease family
F11_RS11795	COG1129	ABC transporter
F11_RS11805	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
F11_RS11810	COG1349	DNA-binding transcription factor activity
F11_RS11830	COG0640	Transcriptional regulator
F11_RS11835	COG0446	pyridine nucleotide-disulphide oxidoreductase
F11_RS11850	COG1629	transport
F11_RS11850	COG4774	siderophore transport
F11_RS11870	COG1396	sequence-specific DNA binding
F11_RS11870	COG3800	Transcriptional regulator
F11_RS11875	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F11_RS11880	COG2079	MmgE PrpD family protein
F11_RS11890	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
F11_RS11900	COG0835	chemotaxis
F11_RS11905	COG2201	protein-glutamate methylesterase activity
F11_RS11915	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
F11_RS11925	COG2198	Histidine kinase
F11_RS11925	COG0643	Histidine kinase
F11_RS11935	COG1192	Involved in chromosome partitioning
F11_RS11940	COG0745	RESPONSE REGULATOR receiver
F11_RS11965	COG2207	Transcriptional regulator
F11_RS11975	COG4771	TonB-dependent receptor
F11_RS11985	COG1132	(ABC) transporter
F11_RS12010	COG1468	defense response to virus
F11_RS12035	COG0438	transferase activity, transferring glycosyl groups
F11_RS12045	COG4106	trans-aconitate 2-methyltransferase activity
F11_RS12100	COG0747	negative chemotaxis
F11_RS12105	COG0601	transmembrane transport
F11_RS12110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F11_RS12115	COG0444	Belongs to the ABC transporter superfamily
F11_RS12120	COG4608	Belongs to the ABC transporter superfamily
F11_RS12130	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F11_RS12145	COG1643	Atp-dependent helicase
F11_RS12165	COG2133	pyrroloquinoline quinone binding
F11_RS12190	COG4774	siderophore transport
F11_RS12205	COG3609	addiction module antidote protein, CC2985 family
F11_RS12220	COG2807	transmembrane transport
F11_RS12225	COG3040	lipid binding
F11_RS12230	COG1174	glycine betaine transport
F11_RS12235	COG1125	glycine betaine transport
F11_RS12240	COG1174	glycine betaine transport
F11_RS12245	COG1732	Glycine betaine
F11_RS12265	COG1121	(ABC) transporter
F11_RS12295	COG4774	siderophore transport
F11_RS12305	COG1595	DNA-templated transcription, initiation
F11_RS12310	COG1013	pyruvate-flavodoxin oxidoreductase activity
F11_RS12310	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F11_RS12310	COG0674	pyruvate-flavodoxin oxidoreductase activity
F11_RS12320	COG1850	ribulose-bisphosphate carboxylase activity
F11_RS12335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
F11_RS12340	COG3954	Phosphoribulokinase
F11_RS12345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
F11_RS12360	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F11_RS12375	COG0436	Aminotransferase
F11_RS12380	COG2885	chlorophyll binding
F11_RS12385	COG3243	poly(R)-hydroxyalkanoic acid synthase
F11_RS12405	COG1464	Belongs to the NlpA lipoprotein family
F11_RS12410	COG2011	ABC-type metal ion transport system permease component
F11_RS12415	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
F11_RS12420	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
F11_RS12425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F11_RS12435	COG0436	Aminotransferase
F11_RS12455	COG1346	cytolysis
F11_RS12470	COG3093	addiction module antidote protein HigA
F11_RS12480	COG2022	thiamine diphosphate biosynthetic process
F11_RS12485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
F11_RS12490	COG0511	ligase activity, forming carbon-carbon bonds
F11_RS12495	COG0439	Biotin carboxylase
F11_RS12500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
F11_RS12525	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F11_RS12535	COG3550	peptidyl-serine autophosphorylation
F11_RS12545	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F11_RS12555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
F11_RS12555	COG3008	intermembrane lipid transfer
F11_RS12600	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F11_RS12630	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
F11_RS12645	COG0469	pyruvate kinase activity
F11_RS12650	COG0346	lactoylglutathione lyase activity
F11_RS12655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F11_RS12665	COG1918	ferrous iron import across plasma membrane
F11_RS12685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS12685	COG4191	Histidine kinase
F11_RS12695	COG4175	Glycine betaine
F11_RS12700	COG4176	ABC-type proline glycine betaine transport system permease component
F11_RS12705	COG2113	Glycine betaine
F11_RS12710	COG1703	isobutyryl-CoA mutase activity
F11_RS12735	COG0737	Belongs to the 5'-nucleotidase family
F11_RS12745	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
F11_RS12765	COG0753	catalase activity
F11_RS12770	COG2207	Transcriptional regulator
F11_RS12785	COG0438	transferase activity, transferring glycosyl groups
F11_RS12790	COG0463	Glycosyl transferase, family 2
F11_RS12795	COG1215	transferase activity, transferring glycosyl groups
F11_RS12805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F11_RS12820	COG0425	Belongs to the sulfur carrier protein TusA family
F11_RS12835	COG2832	Protein of unknown function (DUF454)
F11_RS12840	COG3622	Belongs to the hyi family
F11_RS12845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F11_RS12850	COG0745	RESPONSE REGULATOR receiver
F11_RS12860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F11_RS12865	COG0156	8-amino-7-oxononanoate synthase activity
F11_RS12880	COG3706	GGDEF domain
F11_RS12885	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS12890	COG0427	acetyl-CoA hydrolase
F11_RS12895	COG3108	Peptidase M15
F11_RS12900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F11_RS12905	COG4191	Histidine kinase
F11_RS12910	COG0318	PFAM AMP-dependent synthetase and ligase
F11_RS12915	COG2095	MarC family integral membrane protein
F11_RS12935	COG2910	NAD(P)H-binding
F11_RS12950	COG0826	peptidase U32
F11_RS12985	COG1749	Flagellar hook protein flgE
F11_RS12990	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F11_RS13010	COG1595	DNA-templated transcription, initiation
F11_RS13025	COG2814	Major facilitator Superfamily
F11_RS13035	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F11_RS13040	COG4251	negative regulation of phosphorylation
F11_RS13045	COG2202	Pas domain
F11_RS13045	COG3920	Histidine kinase
F11_RS13055	COG0840	transmembrane signaling receptor activity
F11_RS13080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F11_RS13095	COG2226	methyltransferase
F11_RS13100	COG2972	Histidine kinase
F11_RS13100	COG0840	transmembrane signaling receptor activity
F11_RS13105	COG3706	GGDEF domain
F11_RS13110	COG4948	Mandelate Racemase Muconate Lactonizing
F11_RS13130	COG1305	Transglutaminase-like
F11_RS13140	COG0835	chemotaxis
F11_RS13155	COG3328	transposase activity
F11_RS13165	COG5002	protein histidine kinase activity
F11_RS13165	COG5001	Diguanylate cyclase
F11_RS13165	COG3447	MASE1 domain protein
F11_RS13170	COG0316	Belongs to the HesB IscA family
F11_RS13175	COG2151	metal-sulfur cluster biosynthetic enzyme
F11_RS13180	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F11_RS13185	COG0719	Fe-S assembly protein
F11_RS13190	COG0396	ATPase activity
F11_RS13195	COG0719	Fe-S assembly protein
F11_RS13210	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
F11_RS13215	COG1523	belongs to the glycosyl hydrolase 13 family
F11_RS13285	COG1783	phage Terminase large subunit
F11_RS13300	COG3706	GGDEF domain
F11_RS13305	COG3706	GGDEF domain
F11_RS13325	COG2822	iron ion transport
F11_RS13335	COG2822	iron ion transport
F11_RS13360	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F11_RS13365	COG4251	negative regulation of phosphorylation
F11_RS13410	COG1396	sequence-specific DNA binding
F11_RS13415	COG0640	Transcriptional regulator
F11_RS13420	COG0123	including yeast histone deacetylase and acetoin utilization protein
F11_RS13430	COG0142	geranyltranstransferase activity
F11_RS13435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F11_RS13440	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F11_RS13445	COG0616	signal peptide processing
F11_RS13455	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F11_RS13460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F11_RS13465	COG1295	ribonuclease BN
F11_RS13470	COG0484	heat shock protein binding
F11_RS13475	COG0259	pyridoxamine-phosphate oxidase activity
F11_RS13480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F11_RS13490	COG1940	carbohydrate kinase activity
F11_RS13495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F11_RS13580	COG0579	oxidoreductase
F11_RS13610	COG1254	Belongs to the acylphosphatase family
F11_RS13640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F11_RS13650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F11_RS13655	COG0203	ribosomal protein L17
F11_RS13660	COG0202	RNA polymerase activity
F11_RS13665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F11_RS13670	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
F11_RS13675	COG0563	adenylate kinase activity
F11_RS13685	COG0200	Binds to the 23S rRNA
F11_RS13690	COG1841	ribosomal large subunit assembly
F11_RS13695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F11_RS13700	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F11_RS13705	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F11_RS13710	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F11_RS13715	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F11_RS13720	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F11_RS13725	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F11_RS13730	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
F11_RS13735	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F11_RS13740	COG0255	Belongs to the universal ribosomal protein uL29 family
F11_RS13745	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
F11_RS13750	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F11_RS13755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F11_RS13760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F11_RS13765	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F11_RS13770	COG0089	rRNA binding
F11_RS13775	COG0088	Forms part of the polypeptide exit tunnel
F11_RS13780	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F11_RS13785	COG0051	transcription antitermination factor activity, RNA binding
F11_RS13790	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F11_RS13795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F11_RS13800	COG0049	tRNA binding
F11_RS13805	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F11_RS13810	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F11_RS13815	COG0085	RNA polymerase activity
F11_RS13820	COG0222	ribosome binding
F11_RS13825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F11_RS13830	COG0081	regulation of translation
F11_RS13835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F11_RS13840	COG0250	Participates in transcription elongation, termination and antitermination
F11_RS13855	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F11_RS13870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F11_RS13895	COG2267	carboxylic ester hydrolase activity
F11_RS13910	COG0187	DNA topoisomerase II activity
F11_RS13950	COG0513	Belongs to the DEAD box helicase family
F11_RS13960	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F11_RS13965	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
F11_RS13965	COG0674	pyruvate-flavodoxin oxidoreductase activity
F11_RS13970	COG1013	pyruvate-flavodoxin oxidoreductase activity
F11_RS13980	COG2267	carboxylic ester hydrolase activity
F11_RS14015	COG3932	Exopolysaccharide synthesis, ExoD
F11_RS14045	COG0463	Glycosyl transferase, family 2
F11_RS14060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
F11_RS14065	COG1086	Polysaccharide biosynthesis protein
F11_RS14090	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
F11_RS14095	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS14100	COG1136	(ABC) transporter
F11_RS14130	COG1278	Cold shock
F11_RS14145	COG0840	transmembrane signaling receptor activity
F11_RS14145	COG0840	transmembrane signaling receptor activity
F11_RS14150	COG0745	RESPONSE REGULATOR receiver
F11_RS14155	COG1151	hydroxylamine reductase activity
F11_RS14180	COG5002	protein histidine kinase activity
F11_RS14180	COG5001	Diguanylate cyclase
F11_RS14185	COG0189	ligase activity
F11_RS14195	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F11_RS14200	COG1530	ribonuclease E activity
F11_RS14205	COG0424	maF-like protein
F11_RS14215	COG5328	Belongs to the UPF0262 family
F11_RS14220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F11_RS14225	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F11_RS14245	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F11_RS14250	COG0697	spore germination
F11_RS14265	COG5564	TIM-barrel signal transduction protein
F11_RS14270	COG5441	Belongs to the UPF0261 family
F11_RS14275	COG0583	DNA-binding transcription factor activity
F11_RS14280	COG3416	Protein conserved in bacteria
F11_RS14285	COG1744	ABC transporter substrate-binding protein PnrA-like
F11_RS14290	COG3845	ABC transporter
F11_RS14295	COG4603	Belongs to the binding-protein-dependent transport system permease family
F11_RS14300	COG1079	Belongs to the binding-protein-dependent transport system permease family
F11_RS14305	COG0402	S-adenosylhomocysteine deaminase activity
F11_RS14310	COG2814	Major facilitator Superfamily
F11_RS14330	COG3214	Protein conserved in bacteria
F11_RS14335	COG0717	Belongs to the dCTP deaminase family
F11_RS14370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F11_RS14385	COG1136	(ABC) transporter
F11_RS14385	COG0577	efflux transmembrane transporter activity
F11_RS14395	COG0577	efflux transmembrane transporter activity
F11_RS14410	COG0672	)-iron permease
F11_RS14420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F11_RS14425	COG0746	molybdenum cofactor guanylyltransferase activity
F11_RS14430	COG0315	cyclic pyranopterin monophosphate synthase activity
F11_RS14435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F11_RS14445	COG1309	transcriptional regulator
F11_RS14455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F11_RS14460	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F11_RS14470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F11_RS14475	COG1684	flagellar biosynthetic protein fliR
F11_RS14480	COG1987	bacterial-type flagellum assembly
F11_RS14485	COG1677	Flagellar hook-basal body complex protein FliE
F11_RS14490	COG1558	bacterial-type flagellum-dependent cell motility
F11_RS14495	COG1815	bacterial-type flagellum-dependent cell motility
F11_RS14500	COG2257	FlhB HrpN YscU SpaS Family
F11_RS14515	COG1338	Plays a role in the flagellum-specific transport system
F11_RS14530	COG1360	Flagellar Motor Protein
F11_RS14550	COG0745	RESPONSE REGULATOR receiver
F11_RS14575	COG4786	Flagellar basal body rod
F11_RS14580	COG4786	Flagellar basal body rod
F11_RS14590	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F11_RS14610	COG1706	bacterial-type flagellum-dependent cell motility
F11_RS14645	COG5442	Flagellar protein FlaF
F11_RS14650	COG5443	negative regulation of bacterial-type flagellum assembly
F11_RS14675	COG2267	carboxylic ester hydrolase activity
F11_RS14680	COG1309	transcriptional regulator
F11_RS14695	COG2264	protein methyltransferase activity
F11_RS14700	COG2423	ornithine cyclodeaminase activity
F11_RS14715	COG1253	flavin adenine dinucleotide binding
F11_RS14720	COG1473	amidohydrolase
F11_RS14735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F11_RS14740	COG0583	DNA-binding transcription factor activity
F11_RS14745	COG0667	Aldo Keto reductase
F11_RS14750	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F11_RS14765	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
F11_RS14765	COG0392	lysyltransferase activity
F11_RS14780	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F11_RS14785	COG0358	DNA primase activity
F11_RS14795	COG0505	Belongs to the CarA family
F11_RS14800	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F11_RS14805	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F11_RS14830	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F11_RS14835	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F11_RS14840	COG1121	(ABC) transporter
F11_RS14850	COG1522	sequence-specific DNA binding
F11_RS14855	COG0450	alkyl hydroperoxide reductase
F11_RS14860	COG0492	ferredoxin-NADP+ reductase activity
F11_RS14865	COG0583	DNA-binding transcription factor activity
F11_RS14885	COG0415	Belongs to the DNA photolyase family
F11_RS14895	COG3328	transposase activity
F11_RS14905	COG1522	sequence-specific DNA binding
F11_RS14915	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F11_RS14920	COG1127	ABC transporter
F11_RS15020	COG0745	RESPONSE REGULATOR receiver
F11_RS15025	COG5002	protein histidine kinase activity
F11_RS15030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F11_RS15065	COG2205	protein histidine kinase activity
F11_RS15070	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F11_RS15080	COG0438	transferase activity, transferring glycosyl groups
F11_RS15085	COG0438	transferase activity, transferring glycosyl groups
F11_RS15100	COG1132	(ABC) transporter
F11_RS15105	COG0795	lipopolysaccharide-transporting ATPase activity
F11_RS15110	COG1703	isobutyryl-CoA mutase activity
F11_RS15120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F11_RS15125	COG0166	Belongs to the GPI family
F11_RS15145	COG0142	geranyltranstransferase activity
F11_RS15155	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F11_RS15165	COG0752	glycyl-tRNA synthetase alpha subunit
F11_RS15170	COG0751	glycine-tRNA ligase activity
F11_RS15175	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F11_RS15175	COG0574	Belongs to the PEP-utilizing enzyme family
F11_RS15185	COG0477	Major facilitator Superfamily
F11_RS15195	COG0604	alcohol dehydrogenase
F11_RS15205	COG2030	dehydratase
F11_RS15210	COG0196	riboflavin kinase activity
F11_RS15215	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F11_RS15220	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F11_RS15230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F11_RS15240	COG2814	Major facilitator Superfamily
F11_RS15245	COG0612	Peptidase, M16
F11_RS15250	COG0612	Peptidase, M16
F11_RS15275	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS15280	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
F11_RS15285	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
F11_RS15290	COG1063	alcohol dehydrogenase
F11_RS15295	COG0500	methyltransferase
F11_RS15300	COG0142	geranyltranstransferase activity
F11_RS15315	COG1053	succinate dehydrogenase
F11_RS15355	COG0489	protein tyrosine kinase activity
F11_RS15365	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
F11_RS15370	COG0280	phosphate acetyltransferase
F11_RS15370	COG0857	belongs to the CobB CobQ family
F11_RS15375	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F11_RS15380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F11_RS15390	COG1966	Carbon starvation protein
F11_RS15395	COG1335	isochorismatase
F11_RS15405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F11_RS15410	COG1773	rubredoxin
F11_RS15440	COG1335	isochorismatase
F11_RS15450	COG1176	ABC-type spermidine putrescine transport system, permease component I
F11_RS15455	COG3842	ATPase activity
F11_RS15470	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS15530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F11_RS15535	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F11_RS15540	COG0546	phosphoglycolate phosphatase activity
F11_RS15555	COG0563	adenylate kinase activity
F11_RS15570	COG1199	ATP-dependent helicase activity
F11_RS15570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F11_RS15595	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F11_RS15615	COG3665	Urea carboxylase-associated protein
F11_RS15630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F11_RS15635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
F11_RS15640	COG0509	glycine decarboxylation via glycine cleavage system
F11_RS15655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F11_RS15660	COG0328	RNA-DNA hybrid ribonuclease activity
F11_RS15680	COG4232	protein-disulfide reductase activity
F11_RS15685	COG1678	Uncharacterized ACR, COG1678
F11_RS15700	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F11_RS15700	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F11_RS15705	COG0604	alcohol dehydrogenase
F11_RS15720	COG2249	NAD(P)H dehydrogenase (quinone) activity
F11_RS15725	COG1309	transcriptional regulator
F11_RS15750	COG0668	transmembrane transport
F11_RS15785	COG1250	3-hydroxyacyl-CoA dehydrogenase
F11_RS15795	COG3657	addiction module killer protein
F11_RS15800	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F11_RS15810	COG1160	GTP binding
F11_RS15840	COG1216	Glycosyl transferase, family 2
F11_RS15875	COG0438	transferase activity, transferring glycosyl groups
F11_RS15905	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F11_RS15910	COG0784	Response regulator, receiver
F11_RS15910	COG5002	protein histidine kinase activity
F11_RS15910	COG2198	Histidine kinase
F11_RS15915	COG2204	response regulator
F11_RS15935	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F11_RS15945	COG1752	Esterase of the alpha-beta hydrolase superfamily
F11_RS15950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F11_RS15970	COG3409	Peptidoglycan-binding domain 1 protein
F11_RS15970	COG3267	Type II secretory pathway component ExeA
F11_RS15990	COG0489	protein tyrosine kinase activity
F11_RS16000	COG0367	asparagine synthase
F11_RS16005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F11_RS16020	COG0438	transferase activity, transferring glycosyl groups
F11_RS16045	COG1131	(ABC) transporter
F11_RS16055	COG3706	GGDEF domain
F11_RS16075	COG1192	Involved in chromosome partitioning
F11_RS16105	COG3395	kinase activity
F11_RS16110	COG0235	Class ii aldolase
F11_RS16125	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
F11_RS16150	COG1136	(ABC) transporter
F11_RS16180	COG2304	oxidoreductase activity
F11_RS16195	COG0477	Major facilitator Superfamily
F11_RS16200	COG0697	spore germination
F11_RS16210	COG1605	Chorismate mutase
F11_RS16210	COG0077	Prephenate dehydratase
F11_RS16215	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F11_RS16230	COG4166	transmembrane transport
F11_RS16235	COG4174	ABC transporter (Permease)
F11_RS16240	COG4239	(ABC) transporter, permease
F11_RS16245	COG4172	Belongs to the ABC transporter superfamily
F11_RS16250	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F11_RS16260	COG1280	lysine exporter protein (LysE YggA)
F11_RS16275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F11_RS16280	COG0154	amidase activity
F11_RS16285	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F11_RS16290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
F11_RS16295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F11_RS16300	COG2770	Histidine kinase
F11_RS16300	COG3437	response regulator, receiver
F11_RS16350	COG0540	Belongs to the ATCase OTCase family
F11_RS16355	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F11_RS16360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F11_RS16365	COG0625	glutathione transferase activity
F11_RS16370	COG0758	DNA mediated transformation
F11_RS16405	COG3842	ATPase activity
F11_RS16410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F11_RS16415	COG0557	exoribonuclease II activity
F11_RS16420	COG0793	Belongs to the peptidase S41A family
F11_RS16425	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F11_RS16430	COG0784	Response regulator, receiver
F11_RS16445	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F11_RS16455	COG2703	oxygen carrier activity
F11_RS16465	COG2205	protein histidine kinase activity
F11_RS16465	COG2202	Pas domain
F11_RS16500	COG4206	TonB-dependent receptor
F11_RS16510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F11_RS16515	COG1120	ATPase activity
F11_RS16535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F11_RS16545	COG2867	negative regulation of translational initiation
F11_RS16560	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
F11_RS16575	COG0612	Peptidase, M16
F11_RS16580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS16585	COG1136	(ABC) transporter
F11_RS16585	COG0577	efflux transmembrane transporter activity
F11_RS16645	COG1196	nuclear chromosome segregation
F11_RS16660	COG1194	a g-specific adenine glycosylase
F11_RS16665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F11_RS16675	COG2884	Cell division ATP-binding protein ftsE
F11_RS16695	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F11_RS16700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
F11_RS16720	COG0287	Prephenate dehydrogenase
F11_RS16725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F11_RS16735	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F11_RS16740	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
F11_RS16740	COG2813	Specifically methylates the guanine in position
F11_RS16755	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F11_RS16780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F11_RS16785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F11_RS16790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F11_RS16825	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F11_RS16830	COG0784	Response regulator, receiver
F11_RS16850	COG1597	lipid kinase activity
F11_RS16855	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F11_RS16880	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
F11_RS16885	COG4251	negative regulation of phosphorylation
F11_RS16905	COG4178	(ABC) transporter
F11_RS17010	COG3646	Phage regulatory protein
F11_RS17035	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
F11_RS17040	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
F11_RS17045	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
F11_RS17050	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F11_RS17070	COG0348	domain, Protein
F11_RS17085	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F11_RS17110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
F11_RS17115	COG3180	Ammonia monooxygenase
F11_RS17120	COG2205	protein histidine kinase activity
F11_RS17125	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F11_RS17135	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F11_RS17140	COG0706	membrane insertase activity
F11_RS17145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F11_RS17150	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F11_RS17155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F11_RS17185	COG0438	transferase activity, transferring glycosyl groups
F11_RS17200	COG0242	peptide deformylase activity
F11_RS17205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F11_RS17210	COG0101	tRNA pseudouridine synthase activity
F11_RS17215	COG2076	Multidrug Resistance protein
F11_RS17225	COG2983	Belongs to the UPF0260 family
F11_RS17240	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F11_RS17250	COG1999	signal sequence binding
F11_RS17265	COG4251	negative regulation of phosphorylation
F11_RS17275	COG0481	GTPase activity
F11_RS17290	COG0583	DNA-binding transcription factor activity
F11_RS17355	COG1492	cobalamin metabolic process
F11_RS17370	COG2875	Belongs to the precorrin methyltransferase family
F11_RS17380	COG1268	BioY protein
F11_RS17385	COG0183	Belongs to the thiolase family
F11_RS17400	COG2308	Evidence 4 Homologs of previously reported genes of
F11_RS17415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F11_RS17425	COG2771	luxR family
F11_RS17430	COG3916	Acyl-homoserine-lactone synthase
F11_RS17440	COG1396	sequence-specific DNA binding
F11_RS17445	COG1959	2 iron, 2 sulfur cluster binding
F11_RS17450	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F11_RS17455	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F11_RS17460	COG4208	sulfate ABC transporter
F11_RS17465	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F11_RS17470	COG3273	potassium ion transport
F11_RS17470	COG0471	metal ion transport
F11_RS17475	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
F11_RS17485	COG0205	6-phosphofructokinase activity
F11_RS17500	COG4679	PFAM Phage derived protein Gp49-like (DUF891)
F11_RS17515	COG1129	ABC transporter
F11_RS17520	COG1137	ATPase activity
F11_RS17545	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
F11_RS17560	COG0745	RESPONSE REGULATOR receiver
F11_RS17565	COG0642	Histidine kinase
F11_RS17570	COG0284	orotidine-5'-phosphate decarboxylase activity
F11_RS17575	COG0135	phosphoribosylanthranilate isomerase activity
F11_RS17585	COG0133	tryptophan synthase activity
F11_RS17600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F11_RS17605	COG0285	dihydrofolate synthase activity
F11_RS17620	COG1074	ATP-dependent DNA helicase activity
F11_RS17625	COG2887	Belongs to the helicase family. UvrD subfamily
F11_RS17630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F11_RS17640	COG0802	atpase or kinase
F11_RS17645	COG0492	ferredoxin-NADP+ reductase activity
F11_RS17655	COG1695	Transcriptional regulator
F11_RS17665	COG2205	protein histidine kinase activity
F11_RS17670	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F11_RS17675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F11_RS17680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F11_RS17685	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F11_RS17685	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F11_RS17690	COG1660	Displays ATPase and GTPase activities
F11_RS17695	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
F11_RS17720	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F11_RS17725	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F11_RS17730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F11_RS17755	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
F11_RS17760	COG1278	Cold shock
F11_RS17780	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F11_RS17785	COG1834	amidinotransferase
F11_RS17805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F11_RS17810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F11_RS17815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F11_RS17820	COG2193	ferroxidase activity
F11_RS17825	COG2166	iron-sulfur cluster assembly
F11_RS17830	COG0583	DNA-binding transcription factor activity
F11_RS17835	COG2814	Major facilitator Superfamily
F11_RS17840	COG5001	Diguanylate cyclase
F11_RS17845	COG2171	N-acyltransferase activity
F11_RS17850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F11_RS17885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F11_RS17890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F11_RS17900	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
F11_RS17935	COG0840	transmembrane signaling receptor activity
F11_RS17945	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
F11_RS17950	COG0310	cobalt ion transport
F11_RS17955	COG0310	cobalt ion transport
F11_RS18010	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F11_RS18015	COG0505	Belongs to the CarA family
F11_RS18020	COG0840	transmembrane signaling receptor activity
F11_RS18025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F11_RS18025	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F11_RS18030	COG3279	Response regulator of the LytR AlgR family
F11_RS18045	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F11_RS18055	COG0628	permease
F11_RS18060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F11_RS18065	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F11_RS18070	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F11_RS18075	COG0072	phenylalanine-tRNA ligase activity
F11_RS18085	COG1872	DUF167
F11_RS18105	COG0559	Belongs to the binding-protein-dependent transport system permease family
F11_RS18110	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F11_RS18115	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F11_RS18135	COG0180	Tryptophanyl-tRNA synthetase
F11_RS18140	COG0778	Nitroreductase
F11_RS18145	COG3609	addiction module antidote protein, CC2985 family
F11_RS18155	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
F11_RS18165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F11_RS18170	COG0281	malic enzyme
F11_RS18170	COG0280	phosphate acetyltransferase
F11_RS18175	COG5002	protein histidine kinase activity
F11_RS18185	COG0025	NhaP-type Na H and K H
F11_RS18205	COG1492	cobalamin metabolic process
F11_RS18210	COG1492	cobalamin metabolic process
F11_RS18215	COG0667	Aldo Keto reductase
F11_RS18235	COG0443	Heat shock 70 kDa protein
F11_RS18250	COG0670	Belongs to the BI1 family
F11_RS18265	COG1132	(ABC) transporter
F11_RS18275	COG0840	transmembrane signaling receptor activity
F11_RS18285	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F11_RS18305	COG0181	hydroxymethylbilane synthase activity
F11_RS18310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
F11_RS18320	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F11_RS18340	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F11_RS18360	COG0501	Belongs to the peptidase M48B family
F11_RS18370	COG2154	pterin-4-alpha-carbinolamine dehydratase
F11_RS18380	COG1067	ATP-dependent peptidase activity
F11_RS18385	COG1183	phosphatidylcholine synthase activity
F11_RS18390	COG0688	phosphatidylethanolamine metabolic process
F11_RS18410	COG0606	chelatase, subunit chli
F11_RS18430	COG0140	phosphoribosyl-ATP diphosphatase activity
F11_RS18435	COG0107	imidazoleglycerol-phosphate synthase activity
F11_RS18440	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F11_RS18445	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F11_RS18450	COG0131	Imidazoleglycerol-phosphate dehydratase
F11_RS18455	COG1396	sequence-specific DNA binding
F11_RS18460	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F11_RS18465	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F11_RS18480	COG1556	Lactate utilization protein
F11_RS18490	COG1139	Iron-sulfur cluster binding protein
F11_RS18495	COG0247	lactate metabolic process
F11_RS18515	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
F11_RS18520	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
F11_RS18525	COG0237	dephospho-CoA kinase activity
F11_RS18530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F11_RS18535	COG0424	maF-like protein
F11_RS18540	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
F11_RS18545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
F11_RS18555	COG1981	membrane
F11_RS18560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F11_RS18570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F11_RS18575	COG1331	Highly conserved protein containing a thioredoxin domain
F11_RS18585	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F11_RS18590	COG0445	tRNA wobble uridine modification
F11_RS18595	COG0357	Ribosomal RNA small subunit methyltransferase G
F11_RS18620	COG0495	leucyl-tRNA aminoacylation
F11_RS18635	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F11_RS18655	COG0745	RESPONSE REGULATOR receiver
F11_RS18660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F11_RS18665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F11_RS18670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F11_RS18675	COG1420	regulation of RNA biosynthetic process
F11_RS18680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F11_RS18685	COG1573	uracil-dna glycosylase
F11_RS18695	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F11_RS18705	COG3001	Fructosamine kinase
F11_RS18710	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F11_RS18720	COG1136	(ABC) transporter
F11_RS18735	COG0393	Putative heavy-metal-binding
F11_RS18740	COG0138	bifunctional purine biosynthesis protein purh
F11_RS18750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F11_RS18760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F11_RS18765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F11_RS18765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F11_RS18780	COG2902	Dehydrogenase
F11_RS18785	COG0410	ABC transporter
F11_RS18800	COG1028	Short-chain dehydrogenase reductase Sdr
F11_RS18815	COG4651	solute:proton antiporter activity
F11_RS18815	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F11_RS18820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F11_RS18830	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
F11_RS18860	COG0772	Belongs to the SEDS family
F11_RS18870	COG2353	YceI-like domain
F11_RS18875	COG3038	cytochrome b561
F11_RS18885	COG0457	Tetratricopeptide repeat
F11_RS18895	COG0686	Belongs to the AlaDH PNT family
F11_RS18905	COG1122	ATPase activity
F11_RS18915	COG0189	ligase activity
F11_RS18925	COG0792	nuclease activity
F11_RS18930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F11_RS18940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F11_RS18960	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F11_RS18965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F11_RS18985	COG0803	Belongs to the bacterial solute-binding protein 9 family
F11_RS19000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F11_RS19010	COG2835	tetraacyldisaccharide 4'-kinase activity
F11_RS19035	COG2135	peptidase activity
F11_RS19075	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
F11_RS19085	COG0754	glutathionylspermidine amidase activity
F11_RS19100	COG0559	Belongs to the binding-protein-dependent transport system permease family
F11_RS19140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F11_RS19160	COG4974	Belongs to the 'phage' integrase family
F11_RS19170	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F11_RS19175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F11_RS19190	COG0517	IMP dehydrogenase activity
F11_RS19200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F11_RS19205	COG0193	aminoacyl-tRNA hydrolase activity
F11_RS19210	COG0012	GTP binding
F11_RS19215	COG1196	nuclear chromosome segregation
F11_RS19225	COG0137	argininosuccinate synthase activity
F11_RS19245	COG0071	Belongs to the small heat shock protein (HSP20) family
F11_RS19250	COG2205	protein histidine kinase activity
F11_RS19250	COG0784	Response regulator, receiver
F11_RS19275	COG0443	Heat shock 70 kDa protein
F11_RS19280	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
F11_RS19300	COG4957	zinc ion binding
F11_RS19315	COG0204	Acyl-transferase
F11_RS19320	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F11_RS19325	COG1702	phosphate starvation-inducible protein PhoH
F11_RS19330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
F11_RS19335	COG1253	flavin adenine dinucleotide binding
F11_RS19340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F11_RS19345	COG1396	sequence-specific DNA binding
F11_RS19350	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F11_RS19355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F11_RS19360	COG0779	Required for maturation of 30S ribosomal subunits
F11_RS19365	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F11_RS19365	COG0195	Participates in both transcription termination and antitermination
F11_RS19375	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F11_RS19380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F11_RS19385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F11_RS19390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F11_RS19395	COG1185	polyribonucleotide nucleotidyltransferase activity
F11_RS19400	COG0584	glycerophosphoryl diester phosphodiesterase
F11_RS19435	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F11_RS19440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F11_RS19445	COG1959	2 iron, 2 sulfur cluster binding
F11_RS19450	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F11_RS19455	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F11_RS19465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
F11_RS19475	COG1024	Enoyl-CoA hydratase
F11_RS19480	COG0268	Binds directly to 16S ribosomal RNA
F11_RS19505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F11_RS19525	COG0438	transferase activity, transferring glycosyl groups
F11_RS19535	COG3300	MHYT domain
F11_RS19535	COG5001	Diguanylate cyclase