locus-tag	class	description
A3305_RS00025	COG3328	transposase activity
A3305_RS00070	COG3328	transposase activity
A3305_RS00125	COG2205	protein histidine kinase activity
A3305_RS00125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3305_RS00135	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS00135	COG0666	response to abiotic stimulus
A3305_RS00225	COG0477	Major facilitator Superfamily
A3305_RS00230	COG2264	protein methyltransferase activity
A3305_RS00310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A3305_RS00345	COG1196	nuclear chromosome segregation
A3305_RS00385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A3305_RS00420	COG2814	Major facilitator Superfamily
A3305_RS00430	COG0012	GTP binding
A3305_RS00470	COG0602	queuosine metabolic process
A3305_RS00510	COG0666	response to abiotic stimulus
A3305_RS00525	COG0598	Magnesium transport protein CorA
A3305_RS00560	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A3305_RS00605	COG4770	biotin carboxylase activity
A3305_RS00610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3305_RS00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A3305_RS00665	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS00730	COG0628	permease
A3305_RS00770	COG0268	Binds directly to 16S ribosomal RNA
A3305_RS00795	COG0563	adenylate kinase activity
A3305_RS00800	COG0201	protein transport
A3305_RS00830	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3305_RS00860	COG0255	Belongs to the universal ribosomal protein uL29 family
A3305_RS00865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A3305_RS00885	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3305_RS00890	COG0089	rRNA binding
A3305_RS00950	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3305_RS00965	COG4574	serine-type endopeptidase inhibitor activity
A3305_RS00975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A3305_RS00990	COG0513	Belongs to the DEAD box helicase family
A3305_RS01030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A3305_RS01060	COG0708	Exodeoxyribonuclease III
A3305_RS01155	COG0084	hydrolase, TatD family'
A3305_RS01175	COG0477	Major facilitator Superfamily
A3305_RS01195	COG3475	LICD family
A3305_RS01200	COG3475	LICD family
A3305_RS01295	COG1136	(ABC) transporter
A3305_RS01305	COG4536	flavin adenine dinucleotide binding
A3305_RS01310	COG1138	Cytochrome C-type biogenesis protein
A3305_RS01330	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS01360	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3305_RS01375	COG0739	heme binding
A3305_RS01435	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
A3305_RS01440	COG0328	RNA-DNA hybrid ribonuclease activity
A3305_RS01475	COG1074	ATP-dependent DNA helicase activity
A3305_RS01485	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A3305_RS01615	COG3202	ADP transmembrane transporter activity
A3305_RS01700	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A3305_RS01705	COG0683	leucine binding
A3305_RS01715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A3305_RS01720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A3305_RS01725	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A3305_RS01730	COG0527	aspartate kinase activity
A3305_RS01760	COG0477	Major facilitator Superfamily
A3305_RS01770	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A3305_RS01775	COG0495	leucyl-tRNA aminoacylation
A3305_RS01780	COG1426	Protein conserved in bacteria
A3305_RS01785	COG2902	Dehydrogenase
A3305_RS01850	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A3305_RS01855	COG0488	(ABC) transporter
A3305_RS01880	COG0443	Heat shock 70 kDa protein
A3305_RS01915	COG2885	chlorophyll binding
A3305_RS01955	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A3305_RS02020	COG0805	protein transport
A3305_RS02030	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS02030	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS02035	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS02035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS02040	COG3451	type IV secretory pathway VirB4
A3305_RS02050	COG0861	Integral membrane protein TerC family
A3305_RS02055	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A3305_RS02060	COG4797	methyltransferase
A3305_RS02060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3305_RS02070	COG0839	Belongs to the complex I subunit 6 family
A3305_RS02145	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3305_RS02200	COG0525	valine-tRNA ligase activity
A3305_RS02215	COG0799	negative regulation of ribosome biogenesis
A3305_RS02220	COG0271	Belongs to the BolA IbaG family
A3305_RS02325	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A3305_RS02350	COG0024	Methionine aminopeptidase
A3305_RS02360	COG2003	Belongs to the UPF0758 family
A3305_RS02370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A3305_RS02400	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A3305_RS02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A3305_RS02530	COG1573	uracil-dna glycosylase
A3305_RS02575	COG0009	L-threonylcarbamoyladenylate synthase
A3305_RS02600	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A3305_RS02645	COG0170	dolichyl monophosphate biosynthetic process
A3305_RS02650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A3305_RS02655	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A3305_RS02660	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A3305_RS02665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A3305_RS02675	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A3305_RS02680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A3305_RS02700	COG3577	Aspartyl protease
A3305_RS02745	COG3077	Addiction module antitoxin, RelB DinJ family
A3305_RS02760	COG0795	lipopolysaccharide-transporting ATPase activity
A3305_RS02765	COG2927	DNA polymerase III (CHI subunit)
A3305_RS02825	COG3023	N-Acetylmuramoyl-L-alanine amidase
A3305_RS02835	COG0228	four-way junction DNA binding
A3305_RS02840	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A3305_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
A3305_RS02880	COG0477	Major facilitator Superfamily
A3305_RS02905	COG1981	membrane
A3305_RS02940	COG0493	'glutamate synthase
A3305_RS02940	COG0543	2 iron, 2 sulfur cluster binding
A3305_RS03085	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A3305_RS03085	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3305_RS03115	COG4797	methyltransferase
A3305_RS03115	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A3305_RS03135	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
A3305_RS03140	COG0356	it plays a direct role in the translocation of protons across the membrane
A3305_RS03145	COG0495	leucyl-tRNA aminoacylation
A3305_RS03155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A3305_RS03225	COG0617	tRNA 3'-terminal CCA addition
A3305_RS03230	COG0803	Belongs to the bacterial solute-binding protein 9 family
A3305_RS03250	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS03250	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS03350	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A3305_RS03400	COG0668	transmembrane transport
A3305_RS03410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3305_RS03455	COG2271	Major facilitator Superfamily
A3305_RS03485	COG0488	(ABC) transporter
A3305_RS03510	COG0316	Belongs to the HesB IscA family
A3305_RS03520	COG0495	leucyl-tRNA aminoacylation
A3305_RS03565	COG3704	protein secretion by the type IV secretion system
A3305_RS03570	COG3451	type IV secretory pathway VirB4
A3305_RS03630	COG1127	ABC transporter
A3305_RS03645	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A3305_RS03660	COG2853	Lipoprotein
A3305_RS03665	COG0500	methyltransferase
A3305_RS03670	COG2161	toxin-antitoxin pair type II binding
A3305_RS03685	COG2121	Domain of unknown function (DUF374)
A3305_RS03745	COG0477	Major facilitator Superfamily
A3305_RS03775	COG0745	RESPONSE REGULATOR receiver
A3305_RS03785	COG0717	Belongs to the dCTP deaminase family
A3305_RS03845	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A3305_RS03860	COG3660	Nucleoside-diphosphate-sugar epimerase
A3305_RS03870	COG0330	HflC and HflK could
A3305_RS03875	COG0330	HflC and HflK could
A3305_RS03940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A3305_RS03950	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3305_RS03980	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS03980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS03985	COG0567	Dehydrogenase, E1 component
A3305_RS04015	COG0670	Belongs to the BI1 family
A3305_RS04030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3305_RS04055	COG0528	UMP kinase activity
A3305_RS04095	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3305_RS04125	COG2867	negative regulation of translational initiation
A3305_RS04140	COG2155	Conserved Protein
A3305_RS04145	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A3305_RS04155	COG0470	DNA polymerase III
A3305_RS04170	COG1505	serine-type exopeptidase activity
A3305_RS04180	COG1505	serine-type exopeptidase activity
A3305_RS04185	COG1505	serine-type exopeptidase activity
A3305_RS04190	COG1505	serine-type exopeptidase activity
A3305_RS04195	COG1505	serine-type exopeptidase activity
A3305_RS04200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A3305_RS04205	COG0666	response to abiotic stimulus
A3305_RS04215	COG0666	response to abiotic stimulus
A3305_RS04250	COG1301	dicarboxylic acid transport
A3305_RS04280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3305_RS04290	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A3305_RS04300	COG4572	Cation transport regulator
A3305_RS04315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3305_RS04330	COG5468	Lipopolysaccharide-assembly
A3305_RS04335	COG1466	dna polymerase III delta subunit
A3305_RS04350	COG3838	Conjugal transfer protein Trbc
A3305_RS04380	COG4953	penicillin-binding protein 1C
A3305_RS04420	COG1196	nuclear chromosome segregation
A3305_RS04420	COG4625	pathogenesis
A3305_RS04425	COG0589	response to stress
A3305_RS04480	COG5265	(ABC) transporter
A3305_RS04575	COG1132	(ABC) transporter
A3305_RS04585	COG1271	oxidase subunit
A3305_RS04590	COG1294	oxidase, subunit
A3305_RS04660	COG1538	Outer membrane efflux protein
A3305_RS04665	COG3827	peptidoglycan binding
A3305_RS04675	COG0666	response to abiotic stimulus
A3305_RS04685	COG0793	Belongs to the peptidase S41A family
A3305_RS04740	COG2154	pterin-4-alpha-carbinolamine dehydratase
A3305_RS04770	COG0483	inositol monophosphate 1-phosphatase activity
A3305_RS04785	COG1183	phosphatidylcholine synthase activity
A3305_RS04840	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A3305_RS04850	COG1585	Membrane protein implicated in regulation of membrane protease activity
A3305_RS04880	COG1530	ribonuclease E activity
A3305_RS04905	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A3305_RS04915	COG0708	Exodeoxyribonuclease III
A3305_RS04970	COG0723	plastoquinol--plastocyanin reductase activity
A3305_RS05005	COG4804	nuclease activity
A3305_RS05120	COG0772	Belongs to the SEDS family
A3305_RS05135	COG1487	ribonuclease activity
A3305_RS05155	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3305_RS05155	COG2111	Na H antiporter
A3305_RS05160	COG0651	ATP synthesis coupled electron transport
A3305_RS05165	COG1006	Multisubunit Na H antiporter MnhC subunit
A3305_RS05185	COG3736	Type IV secretory pathway, component VirB8
A3305_RS05190	COG3504	Conjugal transfer protein
A3305_RS05235	COG4695	Portal protein
A3305_RS05250	COG0546	phosphoglycolate phosphatase activity
A3305_RS05280	COG1451	nucleotide metabolic process
A3305_RS05320	COG0531	amino acid
A3305_RS05335	COG0488	(ABC) transporter
A3305_RS05340	COG0488	(ABC) transporter
A3305_RS05345	COG0488	(ABC) transporter
A3305_RS05405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS05410	COG0477	Major facilitator Superfamily
A3305_RS05430	COG0537	adenosine 5'-monophosphoramidase activity
A3305_RS05455	COG0606	chelatase, subunit chli
A3305_RS05485	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A3305_RS05500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS05500	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS05505	COG0546	phosphoglycolate phosphatase activity
A3305_RS05535	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3305_RS05550	COG0450	alkyl hydroperoxide reductase
A3305_RS05620	COG0546	phosphoglycolate phosphatase activity
A3305_RS05735	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A3305_RS05775	COG4765	Protein conserved in bacteria
A3305_RS05790	COG4974	Belongs to the 'phage' integrase family
A3305_RS05805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A3305_RS05830	COG2984	ABC transporter substrate binding protein
A3305_RS05835	COG4120	Belongs to the binding-protein-dependent transport system permease family
A3305_RS05840	COG1122	ATPase activity
A3305_RS05875	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A3305_RS05890	COG0281	malic enzyme
A3305_RS05890	COG0280	phosphate acetyltransferase
A3305_RS05910	COG0477	Major facilitator Superfamily
A3305_RS05990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A3305_RS06005	COG3177	Filamentation induced by cAMP protein fic
A3305_RS06040	COG1132	(ABC) transporter
A3305_RS06050	COG1686	Belongs to the peptidase S11 family
A3305_RS06075	COG4633	Protein conserved in bacteria
A3305_RS06085	COG3485	protocatechuate 3,4-dioxygenase
A3305_RS06095	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A3305_RS06095	COG0616	signal peptide processing
A3305_RS06130	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3305_RS06140	COG0110	maltose O-acetyltransferase activity
A3305_RS06155	COG0739	heme binding
A3305_RS06190	COG1519	Transferase
A3305_RS06230	COG0443	Heat shock 70 kDa protein
A3305_RS06250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3305_RS06265	COG0592	DNA-directed DNA polymerase activity
A3305_RS06285	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS06285	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS06310	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A3305_RS06330	COG0745	RESPONSE REGULATOR receiver
A3305_RS06345	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A3305_RS06355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A3305_RS06390	COG4395	Tim44
A3305_RS06410	COG1238	metal cluster binding
A3305_RS06420	COG1714	RDD family
A3305_RS06440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3305_RS06460	COG0596	Alpha beta hydrolase
A3305_RS06480	COG1012	belongs to the aldehyde dehydrogenase family
A3305_RS06490	COG0463	Glycosyl transferase, family 2
A3305_RS06515	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A3305_RS06565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A3305_RS06620	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3305_RS06640	COG1357	PFAM Pentapeptide repeats (8 copies)
A3305_RS06675	COG1137	ATPase activity
A3305_RS06680	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A3305_RS06690	COG0517	IMP dehydrogenase activity
A3305_RS06690	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3305_RS06720	COG1396	sequence-specific DNA binding
A3305_RS06725	COG1295	ribonuclease BN
A3305_RS06790	COG0525	valine-tRNA ligase activity
A3305_RS06800	COG1268	BioY protein
A3305_RS06805	COG0285	dihydrofolate synthase activity
A3305_RS06895	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A3305_RS06915	COG5346	Predicted membrane protein (DUF2335)
A3305_RS06930	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A3305_RS06945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A3305_RS06950	COG0616	signal peptide processing
A3305_RS07030	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS07060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS07065	COG3903	Transcriptional regulator
A3305_RS07065	COG3629	intracellular signal transduction
A3305_RS07075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A3305_RS07075	COG2205	protein histidine kinase activity
A3305_RS07090	COG0728	peptidoglycan biosynthetic process
A3305_RS07115	COG1862	Preprotein translocase
A3305_RS07155	COG2239	Acts as a magnesium transporter
A3305_RS07195	COG0736	holo-[acyl-carrier-protein] synthase activity
A3305_RS07225	COG0666	response to abiotic stimulus
A3305_RS07245	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A3305_RS07270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3305_RS07275	COG2169	Transcriptional regulator
A3305_RS07300	COG2847	Copper chaperone PCu(A)C
A3305_RS07340	COG5462	secreted (periplasmic) protein
A3305_RS07360	COG0768	penicillin binding
A3305_RS07375	COG2204	response regulator
A3305_RS07385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3305_RS07420	COG1024	Enoyl-CoA hydratase
A3305_RS07420	COG1250	3-hydroxyacyl-CoA dehydrogenase
A3305_RS07505	COG1959	2 iron, 2 sulfur cluster binding
A3305_RS07545	COG1214	PFAM Peptidase M22, glycoprotease
A3305_RS07570	COG0742	ribosomal rna small subunit methyltransferase
A3305_RS07585	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A3305_RS07590	COG0814	amino acid
A3305_RS07625	COG0163	prenyltransferase activity
A3305_RS07645	COG0113	porphobilinogen synthase activity
A3305_RS07730	COG1104	cysteine desulfurase activity
A3305_RS07740	COG0822	iron-sulfur transferase activity
A3305_RS07745	COG0316	Belongs to the HesB IscA family
A3305_RS07775	COG0531	amino acid
A3305_RS07780	COG0567	Dehydrogenase, E1 component
A3305_RS07795	COG0142	geranyltranstransferase activity
A3305_RS07800	COG3307	-O-antigen
A3305_RS07835	COG1279	arginine transmembrane transporter activity
A3305_RS07840	COG1587	Uroporphyrinogen-III synthase
A3305_RS07845	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3305_RS07850	COG3071	HemY protein
A3305_RS07855	COG2945	thiolester hydrolase activity
A3305_RS07865	COG5622	Protein required for attachment to host cells
A3305_RS07945	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A3305_RS07955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A3305_RS07960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A3305_RS07965	COG2226	methyltransferase
A3305_RS08015	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A3305_RS08020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A3305_RS08020	COG2890	protein-(glutamine-N5) methyltransferase activity
A3305_RS08030	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3305_RS08225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A3305_RS08285	COG3621	Patatin-like phospholipase
A3305_RS08300	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A3305_RS08305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A3305_RS08345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A3305_RS08370	COG1192	Involved in chromosome partitioning
A3305_RS08525	COG2176	DNA-directed DNA polymerase activity
A3305_RS08560	COG0415	Belongs to the DNA photolyase family
A3305_RS08615	COG2894	cell division