locus-tag	class	description
A1E_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A1E_RS00025	COG0543	2 iron, 2 sulfur cluster binding
A1E_RS00025	COG0493	'glutamate synthase
A1E_RS00030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1E_RS00035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A1E_RS00040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1E_RS00060	COG0803	Belongs to the bacterial solute-binding protein 9 family
A1E_RS00065	COG0617	tRNA 3'-terminal CCA addition
A1E_RS00075	COG4625	pathogenesis
A1E_RS00075	COG1196	nuclear chromosome segregation
A1E_RS00090	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A1E_RS00095	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A1E_RS00100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1E_RS00105	COG0356	it plays a direct role in the translocation of protons across the membrane
A1E_RS00110	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
A1E_RS00115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A1E_RS00125	COG4797	methyltransferase
A1E_RS00125	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A1E_RS00130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A1E_RS00140	COG1678	Uncharacterized ACR, COG1678
A1E_RS00155	COG0542	response to heat
A1E_RS00165	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A1E_RS00175	COG0360	Binds together with S18 to 16S ribosomal RNA
A1E_RS00180	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A1E_RS00185	COG0359	binds to the 23S rRNA
A1E_RS00190	COG0037	tRNA processing
A1E_RS00210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A1E_RS00215	COG0668	transmembrane transport
A1E_RS00220	COG0706	membrane insertase activity
A1E_RS00240	COG3202	ADP transmembrane transporter activity
A1E_RS00245	COG2271	Major facilitator Superfamily
A1E_RS00250	COG0105	UTP biosynthetic process
A1E_RS00255	COG0445	tRNA wobble uridine modification
A1E_RS00270	COG0488	(ABC) transporter
A1E_RS00280	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A1E_RS00285	COG0316	Belongs to the HesB IscA family
A1E_RS00290	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A1E_RS00295	COG0018	arginyl-trna synthetase
A1E_RS00315	COG0717	Belongs to the dCTP deaminase family
A1E_RS00320	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
A1E_RS00325	COG0745	RESPONSE REGULATOR receiver
A1E_RS00330	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A1E_RS00330	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A1E_RS00355	COG0697	spore germination
A1E_RS00360	COG0477	Major facilitator Superfamily
A1E_RS00385	COG0215	cysteine-tRNA ligase activity
A1E_RS00390	COG0052	Belongs to the universal ribosomal protein uS2 family
A1E_RS00395	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A1E_RS00400	COG1519	Transferase
A1E_RS00405	COG2121	Domain of unknown function (DUF374)
A1E_RS00410	COG0436	Aminotransferase
A1E_RS00415	COG0500	methyltransferase
A1E_RS00420	COG2853	Lipoprotein
A1E_RS00430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1E_RS00435	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A1E_RS00440	COG1127	ABC transporter
A1E_RS00450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A1E_RS00465	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A1E_RS00475	COG3451	type IV secretory pathway VirB4
A1E_RS00480	COG3704	protein secretion by the type IV secretion system
A1E_RS00490	COG3704	protein secretion by the type IV secretion system
A1E_RS00505	COG0280	phosphate acetyltransferase
A1E_RS00515	COG0336	Belongs to the RNA methyltransferase TrmD family
A1E_RS00520	COG0335	large ribosomal subunit rRNA binding
A1E_RS00525	COG3750	Belongs to the UPF0335 family
A1E_RS00530	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A1E_RS00535	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
A1E_RS00540	COG0681	Belongs to the peptidase S26 family
A1E_RS00545	COG0571	ribonuclease III activity
A1E_RS00550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A1E_RS00560	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A1E_RS00565	COG3660	Nucleoside-diphosphate-sugar epimerase
A1E_RS00575	COG0330	HflC and HflK could
A1E_RS00580	COG0330	HflC and HflK could
A1E_RS00590	COG1054	Belongs to the UPF0176 family
A1E_RS00595	COG2009	succinate dehydrogenase
A1E_RS00615	COG0765	amino acid transport
A1E_RS00620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A1E_RS00625	COG0049	tRNA binding
A1E_RS00630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A1E_RS00640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A1E_RS00645	COG0250	Participates in transcription elongation, termination and antitermination
A1E_RS00650	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A1E_RS00655	COG0081	regulation of translation
A1E_RS00660	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A1E_RS00665	COG0222	ribosome binding
A1E_RS00670	COG0085	RNA polymerase activity
A1E_RS00675	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A1E_RS00685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A1E_RS00700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A1E_RS00705	COG0670	Belongs to the BI1 family
A1E_RS00710	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A1E_RS00720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A1E_RS00725	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1E_RS00730	COG0154	amidase activity
A1E_RS00735	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A1E_RS00740	COG0233	cytoplasmic translational termination
A1E_RS00745	COG0528	UMP kinase activity
A1E_RS00770	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1E_RS00785	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A1E_RS00800	COG2867	negative regulation of translational initiation
A1E_RS00805	COG2171	N-acyltransferase activity
A1E_RS00815	COG3838	Conjugal transfer protein Trbc
A1E_RS00830	COG1466	dna polymerase III delta subunit
A1E_RS00835	COG5468	Lipopolysaccharide-assembly
A1E_RS00845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A1E_RS00850	COG0443	Heat shock 70 kDa protein
A1E_RS00855	COG0484	heat shock protein binding
A1E_RS00865	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A1E_RS00870	COG0497	DNA recombination
A1E_RS00875	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A1E_RS00885	COG0508	dehydrogenase complex catalyzes the overall conversion of
A1E_RS00900	COG1301	dicarboxylic acid transport
A1E_RS00910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A1E_RS00920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A1E_RS00925	COG0470	DNA polymerase III
A1E_RS00930	COG0776	regulation of translation
A1E_RS00935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A1E_RS00940	COG2155	Conserved Protein
A1E_RS00960	COG0589	response to stress
A1E_RS00985	COG0484	heat shock protein binding
A1E_RS00990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A1E_RS00995	COG0556	nucleotide-excision repair
A1E_RS01000	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A1E_RS01010	COG1074	ATP-dependent DNA helicase activity
A1E_RS01040	COG0328	RNA-DNA hybrid ribonuclease activity
A1E_RS01045	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
A1E_RS01080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A1E_RS01090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A1E_RS01095	COG0242	peptide deformylase activity
A1E_RS01100	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A1E_RS01125	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A1E_RS01130	COG1132	(ABC) transporter
A1E_RS01140	COG1271	oxidase subunit
A1E_RS01145	COG1294	oxidase, subunit
A1E_RS01150	COG0463	Glycosyl transferase, family 2
A1E_RS01155	COG0612	Peptidase, M16
A1E_RS01160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A1E_RS01170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A1E_RS01195	COG1538	Outer membrane efflux protein
A1E_RS01200	COG3827	peptidoglycan binding
A1E_RS01205	COG0666	response to abiotic stimulus
A1E_RS01210	COG0187	DNA topoisomerase II activity
A1E_RS01215	COG0793	Belongs to the peptidase S41A family
A1E_RS01240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A1E_RS01245	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A1E_RS01260	COG2154	pterin-4-alpha-carbinolamine dehydratase
A1E_RS01265	COG0494	nUDIX hydrolase
A1E_RS01275	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A1E_RS01280	COG0483	inositol monophosphate 1-phosphatase activity
A1E_RS01290	COG0688	phosphatidylethanolamine metabolic process
A1E_RS01295	COG1183	phosphatidylcholine synthase activity
A1E_RS01315	COG2771	luxR family
A1E_RS01315	COG2200	EAL domain
A1E_RS01320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A1E_RS01325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A1E_RS01330	COG1181	Belongs to the D-alanine--D-alanine ligase family
A1E_RS01335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A1E_RS01350	COG1585	Membrane protein implicated in regulation of membrane protease activity
A1E_RS01355	COG3474	cytochrome
A1E_RS01365	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A1E_RS01375	COG1530	ribonuclease E activity
A1E_RS01380	COG1612	heme a metabolic process
A1E_RS01390	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A1E_RS01395	COG0708	Exodeoxyribonuclease III
A1E_RS01400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A1E_RS01405	COG0022	dehydrogenase e1 component
A1E_RS01410	COG1217	gtp-binding protein TYPA
A1E_RS01425	COG0473	3-isopropylmalate dehydrogenase activity
A1E_RS01450	COG0723	plastoquinol--plastocyanin reductase activity
A1E_RS01455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A1E_RS01475	COG0481	GTPase activity
A1E_RS01500	COG0628	permease
A1E_RS01505	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A1E_RS01510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A1E_RS01520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A1E_RS01525	COG0459	protein refolding
A1E_RS01530	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1E_RS01540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1E_RS01545	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
A1E_RS01550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A1E_RS01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A1E_RS01570	COG4770	biotin carboxylase activity
A1E_RS01575	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A1E_RS01585	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A1E_RS01590	COG5000	phosphorelay sensor kinase activity
A1E_RS01610	COG0594	ribonuclease P activity
A1E_RS01615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A1E_RS01620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A1E_RS01625	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A1E_RS01630	COG0602	queuosine metabolic process
A1E_RS01635	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A1E_RS01640	COG0193	aminoacyl-tRNA hydrolase activity
A1E_RS01650	COG0012	GTP binding
A1E_RS01660	COG2814	Major facilitator Superfamily
A1E_RS01685	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A1E_RS01700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A1E_RS01715	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1E_RS01720	COG1196	nuclear chromosome segregation
A1E_RS01730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A1E_RS01745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A1E_RS01750	COG1917	Cupin 2, conserved barrel domain protein
A1E_RS01765	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A1E_RS01770	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A1E_RS01785	COG1862	Preprotein translocase
A1E_RS01795	COG2239	Acts as a magnesium transporter
A1E_RS01825	COG0187	DNA topoisomerase II activity
A1E_RS01830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A1E_RS01835	COG1758	RNA polymerase activity
A1E_RS01840	COG0736	holo-[acyl-carrier-protein] synthase activity
A1E_RS01845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A1E_RS01850	COG0653	protein targeting
A1E_RS01860	COG0666	response to abiotic stimulus
A1E_RS01900	COG0322	excinuclease ABC activity
A1E_RS01905	COG2847	Copper chaperone PCu(A)C
A1E_RS01925	COG2001	Belongs to the MraZ family
A1E_RS01930	COG0275	rRNA processing
A1E_RS01935	COG5462	secreted (periplasmic) protein
A1E_RS01950	COG0768	penicillin binding
A1E_RS01970	COG2204	response regulator
A1E_RS01980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A1E_RS02000	COG0477	Major facilitator Superfamily
A1E_RS02030	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A1E_RS02055	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A1E_RS02065	COG1214	PFAM Peptidase M22, glycoprotease
A1E_RS02070	COG1381	Involved in DNA repair and RecF pathway recombination
A1E_RS02080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A1E_RS02085	COG0742	ribosomal rna small subunit methyltransferase
A1E_RS02095	COG1187	pseudouridine synthase activity
A1E_RS02105	COG0305	Participates in initiation and elongation during chromosome replication
A1E_RS02110	COG0163	prenyltransferase activity
A1E_RS02125	COG0113	porphobilinogen synthase activity
A1E_RS02135	COG1007	ATP synthesis coupled electron transport
A1E_RS02155	COG1104	cysteine desulfurase activity
A1E_RS02160	COG1104	cysteine desulfurase activity
A1E_RS02165	COG0822	iron-sulfur transferase activity
A1E_RS02170	COG0316	Belongs to the HesB IscA family
A1E_RS02175	COG0531	amino acid
A1E_RS02180	COG0006	proline dipeptidase activity
A1E_RS02195	COG0142	geranyltranstransferase activity
A1E_RS02205	COG3202	ADP transmembrane transporter activity
A1E_RS02220	COG1279	arginine transmembrane transporter activity
A1E_RS02225	COG1587	Uroporphyrinogen-III synthase
A1E_RS02230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1E_RS02235	COG3071	HemY protein
A1E_RS02240	COG2945	thiolester hydrolase activity
A1E_RS02245	COG5622	Protein required for attachment to host cells
A1E_RS02255	COG0180	Tryptophanyl-tRNA synthetase
A1E_RS02265	COG0181	hydroxymethylbilane synthase activity
A1E_RS02295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
A1E_RS02300	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A1E_RS02305	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1E_RS02310	COG2226	methyltransferase
A1E_RS02330	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A1E_RS02335	COG0217	transcriptional regulatory protein
A1E_RS02340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A1E_RS02360	COG1304	FMN binding
A1E_RS02375	COG0740	serine-type endopeptidase activity
A1E_RS02380	COG0539	negative regulation of cytoplasmic translation
A1E_RS02385	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A1E_RS02490	COG0616	signal peptide processing
A1E_RS02495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A1E_RS02505	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A1E_RS02510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A1E_RS02525	COG5346	Predicted membrane protein (DUF2335)
A1E_RS02560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A1E_RS02565	COG0285	dihydrofolate synthase activity
A1E_RS02570	COG1268	BioY protein
A1E_RS02615	COG1295	ribonuclease BN
A1E_RS02620	COG1396	sequence-specific DNA binding
A1E_RS02625	COG5183	chlorophyll binding
A1E_RS02630	COG3202	ADP transmembrane transporter activity
A1E_RS02635	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A1E_RS02640	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A1E_RS02645	COG1185	polyribonucleotide nucleotidyltransferase activity
A1E_RS02650	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A1E_RS02650	COG0517	IMP dehydrogenase activity
A1E_RS02660	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
A1E_RS02665	COG1137	ATPase activity
A1E_RS02675	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A1E_RS02680	COG1357	PFAM Pentapeptide repeats (8 copies)
A1E_RS02685	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A1E_RS02695	COG0492	ferredoxin-NADP+ reductase activity
A1E_RS02700	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A1E_RS02705	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A1E_RS02750	COG0210	DNA helicase
A1E_RS02755	COG0463	Glycosyl transferase, family 2
A1E_RS02780	COG0596	Alpha beta hydrolase
A1E_RS02800	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A1E_RS02815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A1E_RS02820	COG1714	RDD family
A1E_RS02825	COG1238	metal cluster binding
A1E_RS02830	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A1E_RS02835	COG4395	Tim44
A1E_RS02845	COG0045	succinate-CoA ligase (ADP-forming) activity
A1E_RS02850	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A1E_RS02860	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A1E_RS02865	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A1E_RS02870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A1E_RS02875	COG0745	RESPONSE REGULATOR receiver
A1E_RS02880	COG2205	protein histidine kinase activity
A1E_RS02890	COG0575	Belongs to the CDS family
A1E_RS02895	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A1E_RS02905	COG0495	leucyl-tRNA aminoacylation
A1E_RS02915	COG0592	DNA-directed DNA polymerase activity
A1E_RS02925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A1E_RS02930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1E_RS02935	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A1E_RS02945	COG1519	Transferase
A1E_RS02960	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A1E_RS02980	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A1E_RS02990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A1E_RS02995	COG0739	heme binding
A1E_RS03000	COG1565	acr, cog1565
A1E_RS03000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A1E_RS03010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1E_RS03015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A1E_RS03035	COG0756	dUTP diphosphatase activity
A1E_RS03040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A1E_RS03040	COG0616	signal peptide processing
A1E_RS03050	COG3485	protocatechuate 3,4-dioxygenase
A1E_RS03055	COG0545	Peptidyl-prolyl cis-trans isomerase
A1E_RS03060	COG4633	Protein conserved in bacteria
A1E_RS03070	COG2917	probably involved in intracellular septation
A1E_RS03085	COG1686	Belongs to the peptidase S11 family
A1E_RS03090	COG2211	Major facilitator Superfamily
A1E_RS03095	COG1132	(ABC) transporter
A1E_RS03100	COG2255	four-way junction helicase activity
A1E_RS03115	COG0632	four-way junction helicase activity
A1E_RS03135	COG0442	prolyl-tRNA aminoacylation
A1E_RS03140	COG0302	gtp cyclohydrolase
A1E_RS03145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A1E_RS03160	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A1E_RS03170	COG3202	ADP transmembrane transporter activity
A1E_RS03175	COG0039	L-malate dehydrogenase activity
A1E_RS03200	COG0477	Major facilitator Superfamily
A1E_RS03205	COG0281	malic enzyme
A1E_RS03205	COG0280	phosphate acetyltransferase
A1E_RS03215	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A1E_RS03240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A1E_RS03245	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A1E_RS03255	COG4974	Belongs to the 'phage' integrase family
A1E_RS03265	COG4765	Protein conserved in bacteria
A1E_RS03280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1E_RS03285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1E_RS03295	COG0649	NAD binding
A1E_RS03305	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A1E_RS03310	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A1E_RS03320	COG1722	exodeoxyribonuclease VII activity
A1E_RS03330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A1E_RS03350	COG0109	protoheme IX farnesyltransferase activity
A1E_RS03355	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A1E_RS03375	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A1E_RS03385	COG1216	Glycosyl transferase, family 2
A1E_RS03395	COG0297	glycogen (starch) synthase activity
A1E_RS03410	COG1086	Polysaccharide biosynthesis protein
A1E_RS03420	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A1E_RS03435	COG0450	alkyl hydroperoxide reductase
A1E_RS03445	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A1E_RS03450	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A1E_RS03470	COG1965	Belongs to the frataxin family
A1E_RS03475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A1E_RS03485	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A1E_RS03505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A1E_RS03510	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A1E_RS03520	COG0537	adenosine 5'-monophosphoramidase activity
A1E_RS03540	COG0477	Major facilitator Superfamily
A1E_RS03545	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1E_RS03570	COG0124	histidyl-tRNA synthetase
A1E_RS03575	COG0531	amino acid
A1E_RS03580	COG0482	sulfurtransferase activity
A1E_RS03600	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
A1E_RS03610	COG0823	Involved in the tonB-independent uptake of proteins
A1E_RS03615	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A1E_RS03635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A1E_RS03640	COG1218	3'(2'),5'-bisphosphate nucleotidase
A1E_RS03645	COG0546	phosphoglycolate phosphatase activity
A1E_RS03705	COG2948	multi-organism process
A1E_RS03710	COG3504	Conjugal transfer protein
A1E_RS03715	COG3736	Type IV secretory pathway, component VirB8
A1E_RS03735	COG1006	Multisubunit Na H antiporter MnhC subunit
A1E_RS03740	COG0651	ATP synthesis coupled electron transport
A1E_RS03750	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A1E_RS03750	COG2111	Na H antiporter
A1E_RS03760	COG1487	ribonuclease activity
A1E_RS03775	COG0772	Belongs to the SEDS family
A1E_RS03785	COG0268	Binds directly to 16S ribosomal RNA
A1E_RS03790	COG0203	ribosomal protein L17
A1E_RS03795	COG0202	RNA polymerase activity
A1E_RS03800	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A1E_RS03810	COG0563	adenylate kinase activity
A1E_RS03815	COG0201	protein transport
A1E_RS03820	COG0200	Binds to the 23S rRNA
A1E_RS03825	COG1841	ribosomal large subunit assembly
A1E_RS03830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A1E_RS03835	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A1E_RS03840	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A1E_RS03845	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A1E_RS03850	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A1E_RS03855	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A1E_RS03860	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A1E_RS03865	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A1E_RS03870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A1E_RS03875	COG0255	Belongs to the universal ribosomal protein uL29 family
A1E_RS03880	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A1E_RS03885	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A1E_RS03890	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A1E_RS03895	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A1E_RS03900	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A1E_RS03905	COG0089	rRNA binding
A1E_RS03910	COG0088	Forms part of the polypeptide exit tunnel
A1E_RS03915	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A1E_RS03920	COG0051	transcription antitermination factor activity, RNA binding
A1E_RS03925	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A1E_RS03940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A1E_RS03960	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A1E_RS03970	COG4574	serine-type endopeptidase inhibitor activity
A1E_RS03975	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A1E_RS03980	COG0513	Belongs to the DEAD box helicase family
A1E_RS03985	COG1278	Cold shock
A1E_RS04000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A1E_RS04010	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
A1E_RS04015	COG1570	exodeoxyribonuclease VII activity
A1E_RS04020	COG0708	Exodeoxyribonuclease III
A1E_RS04025	COG1160	GTP binding
A1E_RS04045	COG2226	methyltransferase
A1E_RS04050	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A1E_RS04070	COG0084	hydrolase, TatD family'
A1E_RS04075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A1E_RS04080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A1E_RS04085	COG0477	Major facilitator Superfamily
A1E_RS04100	COG0525	valine-tRNA ligase activity
A1E_RS04115	COG1322	Protein conserved in bacteria
A1E_RS04125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A1E_RS04135	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A1E_RS04170	COG1136	(ABC) transporter
A1E_RS04180	COG4536	flavin adenine dinucleotide binding
A1E_RS04185	COG1138	Cytochrome C-type biogenesis protein
A1E_RS04195	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A1E_RS04200	COG1472	Belongs to the glycosyl hydrolase 3 family
A1E_RS04210	COG1663	tetraacyldisaccharide 4'-kinase activity
A1E_RS04215	COG0739	heme binding
A1E_RS04225	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A1E_RS04235	COG0343	queuine tRNA-ribosyltransferase activity
A1E_RS04250	COG3202	ADP transmembrane transporter activity
A1E_RS04255	COG1253	flavin adenine dinucleotide binding
A1E_RS04260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A1E_RS04265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A1E_RS04270	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A1E_RS04275	COG0400	carboxylic ester hydrolase activity
A1E_RS04280	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
A1E_RS04285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A1E_RS04290	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A1E_RS04295	COG0683	leucine binding
A1E_RS04300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A1E_RS04305	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A1E_RS04310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A1E_RS04315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A1E_RS04320	COG0527	aspartate kinase activity
A1E_RS04330	COG0477	Major facilitator Superfamily
A1E_RS04335	COG1426	Protein conserved in bacteria
A1E_RS04340	COG2902	Dehydrogenase
A1E_RS04345	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A1E_RS04355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A1E_RS04360	COG1028	Short-chain dehydrogenase reductase Sdr
A1E_RS04365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A1E_RS04370	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A1E_RS04390	COG0194	GDP metabolic process
A1E_RS04420	COG2885	chlorophyll binding
A1E_RS04425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A1E_RS04430	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A1E_RS04450	COG0587	DNA-directed DNA polymerase activity
A1E_RS04455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A1E_RS04470	COG0805	protein transport
A1E_RS04475	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A1E_RS04480	COG3451	type IV secretory pathway VirB4
A1E_RS04490	COG0861	Integral membrane protein TerC family
A1E_RS04495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A1E_RS04500	COG4797	methyltransferase
A1E_RS04500	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A1E_RS04505	COG0839	Belongs to the complex I subunit 6 family
A1E_RS04510	COG0713	ATP synthesis coupled electron transport
A1E_RS04520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1E_RS04525	COG4133	protoheme IX ABC transporter activity
A1E_RS04540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A1E_RS04545	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A1E_RS04550	COG1034	ATP synthesis coupled electron transport
A1E_RS04560	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A1E_RS04570	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A1E_RS04575	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A1E_RS04580	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A1E_RS04585	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A1E_RS04590	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A1E_RS04595	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
A1E_RS04600	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A1E_RS04630	COG0799	negative regulation of ribosome biogenesis
A1E_RS04635	COG0271	Belongs to the BolA IbaG family
A1E_RS04665	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A1E_RS04670	COG0424	maF-like protein
A1E_RS04680	COG4974	Belongs to the 'phage' integrase family
A1E_RS04685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A1E_RS04690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A1E_RS04705	COG1674	ftsk spoiiie
A1E_RS04715	COG0024	Methionine aminopeptidase
A1E_RS04725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A1E_RS04740	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
A1E_RS04745	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A1E_RS04750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A1E_RS04775	COG1121	(ABC) transporter
A1E_RS04780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A1E_RS04785	COG0629	single-stranded DNA binding
A1E_RS04800	COG1872	DUF167
A1E_RS04805	COG0326	Molecular chaperone. Has ATPase activity
A1E_RS04810	COG0156	8-amino-7-oxononanoate synthase activity
A1E_RS04815	COG0544	peptidyl-prolyl cis-trans isomerase activity
A1E_RS04820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A1E_RS04825	COG0372	Belongs to the citrate synthase family
A1E_RS04850	COG0009	L-threonylcarbamoyladenylate synthase
A1E_RS04855	COG0751	glycine-tRNA ligase activity
A1E_RS04860	COG0752	glycyl-tRNA synthetase alpha subunit
A1E_RS04865	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A1E_RS04895	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A1E_RS04900	COG0101	tRNA pseudouridine synthase activity
A1E_RS04905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A1E_RS04910	COG0358	DNA primase activity
A1E_RS04915	COG0170	dolichyl monophosphate biosynthetic process
A1E_RS04920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A1E_RS04925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
A1E_RS04935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A1E_RS04940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A1E_RS04945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A1E_RS04950	COG3577	Aspartyl protease
A1E_RS04960	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A1E_RS04960	COG0321	lipoyl(octanoyl) transferase activity
A1E_RS04970	COG0795	lipopolysaccharide-transporting ATPase activity
A1E_RS04975	COG2927	DNA polymerase III (CHI subunit)
A1E_RS04985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A1E_RS04995	COG0321	lipoyl(octanoyl) transferase activity
A1E_RS05000	COG3023	N-Acetylmuramoyl-L-alanine amidase
A1E_RS05010	COG0228	four-way junction DNA binding
A1E_RS05015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A1E_RS05020	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A1E_RS05035	COG0477	Major facilitator Superfamily
A1E_RS05040	COG0408	coproporphyrinogen oxidase activity
A1E_RS05045	COG1981	membrane
A1E_RS05050	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A1E_RS05055	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A1E_RS05125	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity