locus-tag	class	description
M9Y_RS00005	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
M9Y_RS00010	COG3118	belongs to the thioredoxin family
M9Y_RS00025	COG0543	2 iron, 2 sulfur cluster binding
M9Y_RS00025	COG0493	'glutamate synthase
M9Y_RS00030	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9Y_RS00035	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
M9Y_RS00040	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9Y_RS00050	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
M9Y_RS00055	COG0726	polysaccharide deacetylase
M9Y_RS00060	COG0802	atpase or kinase
M9Y_RS00065	COG0803	Belongs to the bacterial solute-binding protein 9 family
M9Y_RS00070	COG0617	tRNA 3'-terminal CCA addition
M9Y_RS00075	COG1196	nuclear chromosome segregation
M9Y_RS00080	COG1196	nuclear chromosome segregation
M9Y_RS00100	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M9Y_RS00105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
M9Y_RS00110	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9Y_RS00115	COG0356	it plays a direct role in the translocation of protons across the membrane
M9Y_RS00120	COG5336	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex
M9Y_RS00125	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
M9Y_RS00135	COG4797	methyltransferase
M9Y_RS00140	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
M9Y_RS00150	COG1999	signal sequence binding
M9Y_RS00155	COG1678	Uncharacterized ACR, COG1678
M9Y_RS00175	COG0542	response to heat
M9Y_RS00180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
M9Y_RS00190	COG0360	Binds together with S18 to 16S ribosomal RNA
M9Y_RS00195	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
M9Y_RS00200	COG0359	binds to the 23S rRNA
M9Y_RS00205	COG0037	tRNA processing
M9Y_RS00210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
M9Y_RS00215	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
M9Y_RS00225	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
M9Y_RS00230	COG0668	transmembrane transport
M9Y_RS00235	COG0706	membrane insertase activity
M9Y_RS00240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
M9Y_RS00245	COG0288	reversible hydration of carbon dioxide
M9Y_RS00260	COG3202	ADP transmembrane transporter activity
M9Y_RS00265	COG2271	Major facilitator Superfamily
M9Y_RS00270	COG0105	UTP biosynthetic process
M9Y_RS00275	COG0445	tRNA wobble uridine modification
M9Y_RS00280	COG0357	Ribosomal RNA small subunit methyltransferase G
M9Y_RS00290	COG1475	DNA binding
M9Y_RS00295	COG0488	(ABC) transporter
M9Y_RS00305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
M9Y_RS00310	COG0316	Belongs to the HesB IscA family
M9Y_RS00315	COG0232	Belongs to the dGTPase family. Type 2 subfamily
M9Y_RS00320	COG0018	arginyl-trna synthetase
M9Y_RS00325	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M9Y_RS00330	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M9Y_RS00335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
M9Y_RS00340	COG0717	Belongs to the dCTP deaminase family
M9Y_RS00345	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
M9Y_RS00355	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M9Y_RS00355	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
M9Y_RS00370	COG3047	cAMP biosynthetic process
M9Y_RS00375	COG0697	spore germination
M9Y_RS00380	COG0477	Major facilitator Superfamily
M9Y_RS00390	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9Y_RS00400	COG3468	outer membrane autotransporter barrel domain protein
M9Y_RS00400	COG2188	Transcriptional regulator
M9Y_RS00425	COG0215	cysteine-tRNA ligase activity
M9Y_RS00430	COG0052	Belongs to the universal ribosomal protein uS2 family
M9Y_RS00435	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
M9Y_RS00445	COG1519	Transferase
M9Y_RS00450	COG2121	Domain of unknown function (DUF374)
M9Y_RS00455	COG0436	Aminotransferase
M9Y_RS00460	COG0500	methyltransferase
M9Y_RS00465	COG2853	Lipoprotein
M9Y_RS00475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
M9Y_RS00480	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
M9Y_RS00485	COG1127	ABC transporter
M9Y_RS00495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
M9Y_RS00500	COG0254	rRNA binding
M9Y_RS00510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
M9Y_RS00520	COG3451	type IV secretory pathway VirB4
M9Y_RS00525	COG3704	protein secretion by the type IV secretion system
M9Y_RS00530	COG3704	protein secretion by the type IV secretion system
M9Y_RS00535	COG3704	protein secretion by the type IV secretion system
M9Y_RS00540	COG3704	protein secretion by the type IV secretion system
M9Y_RS00545	COG3704	protein secretion by the type IV secretion system
M9Y_RS00545	COG1340	protein secretion by the type IV secretion system
M9Y_RS00550	COG0280	phosphate acetyltransferase
M9Y_RS00555	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
M9Y_RS00560	COG0336	Belongs to the RNA methyltransferase TrmD family
M9Y_RS00565	COG0335	large ribosomal subunit rRNA binding
M9Y_RS00570	COG3750	Belongs to the UPF0335 family
M9Y_RS00575	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9Y_RS00580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
M9Y_RS00585	COG0681	Belongs to the peptidase S26 family
M9Y_RS00590	COG0571	ribonuclease III activity
M9Y_RS00595	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
M9Y_RS00600	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
M9Y_RS00605	COG3660	Nucleoside-diphosphate-sugar epimerase
M9Y_RS00610	COG0489	protein tyrosine kinase activity
M9Y_RS00615	COG0330	HflC and HflK could
M9Y_RS00620	COG0330	HflC and HflK could
M9Y_RS00625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9Y_RS00630	COG1054	Belongs to the UPF0176 family
M9Y_RS00635	COG2009	succinate dehydrogenase
M9Y_RS00640	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
M9Y_RS00645	COG1053	succinate dehydrogenase
M9Y_RS00650	COG0765	amino acid transport
M9Y_RS00655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
M9Y_RS00660	COG0049	tRNA binding
M9Y_RS00665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
M9Y_RS00675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
M9Y_RS00680	COG0250	Participates in transcription elongation, termination and antitermination
M9Y_RS00685	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
M9Y_RS00690	COG0081	regulation of translation
M9Y_RS00695	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
M9Y_RS00700	COG0222	ribosome binding
M9Y_RS00705	COG0085	RNA polymerase activity
M9Y_RS00710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
M9Y_RS00715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
M9Y_RS00730	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
M9Y_RS00745	COG0670	Belongs to the BI1 family
M9Y_RS00750	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
M9Y_RS00760	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
M9Y_RS00765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M9Y_RS00770	COG0154	amidase activity
M9Y_RS00775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
M9Y_RS00780	COG0233	cytoplasmic translational termination
M9Y_RS00785	COG0528	UMP kinase activity
M9Y_RS00810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9Y_RS00815	COG0750	zinc metalloprotease
M9Y_RS00820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
M9Y_RS00825	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
M9Y_RS00840	COG2867	negative regulation of translational initiation
M9Y_RS00845	COG1385	rRNA (uridine-N3-)-methyltransferase activity
M9Y_RS00850	COG2155	Conserved Protein
M9Y_RS00855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
M9Y_RS00860	COG0776	regulation of translation
M9Y_RS00870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
M9Y_RS00875	COG1505	serine-type exopeptidase activity
M9Y_RS00880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
M9Y_RS00885	COG1301	dicarboxylic acid transport
M9Y_RS00895	COG0720	synthase
M9Y_RS00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9Y_RS00905	COG0567	Dehydrogenase, E1 component
M9Y_RS00915	COG0497	DNA recombination
M9Y_RS00920	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9Y_RS00925	COG0484	heat shock protein binding
M9Y_RS00930	COG0443	Heat shock 70 kDa protein
M9Y_RS00940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9Y_RS00945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
M9Y_RS00950	COG5468	Lipopolysaccharide-assembly
M9Y_RS00955	COG1466	dna polymerase III delta subunit
M9Y_RS00965	COG1845	cytochrome c oxidase, subunit III
M9Y_RS00970	COG3838	Conjugal transfer protein Trbc
M9Y_RS00980	COG2171	N-acyltransferase activity
M9Y_RS00985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
M9Y_RS01000	COG0589	response to stress
M9Y_RS01015	COG0633	Ferredoxin
M9Y_RS01020	COG0443	Heat shock 70 kDa protein
M9Y_RS01025	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
M9Y_RS01030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
M9Y_RS01035	COG0556	nucleotide-excision repair
M9Y_RS01040	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
M9Y_RS01045	COG5265	(ABC) transporter
M9Y_RS01050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
M9Y_RS01065	COG0242	peptide deformylase activity
M9Y_RS01070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
M9Y_RS01090	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
M9Y_RS01095	COG1132	(ABC) transporter
M9Y_RS01105	COG1271	oxidase subunit
M9Y_RS01110	COG1294	oxidase, subunit
M9Y_RS01115	COG0463	Glycosyl transferase, family 2
M9Y_RS01120	COG0612	Peptidase, M16
M9Y_RS01125	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
M9Y_RS01130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
M9Y_RS01145	COG1538	Outer membrane efflux protein
M9Y_RS01150	COG3827	peptidoglycan binding
M9Y_RS01155	COG0666	response to abiotic stimulus
M9Y_RS01160	COG0187	DNA topoisomerase II activity
M9Y_RS01165	COG0793	Belongs to the peptidase S41A family
M9Y_RS01185	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
M9Y_RS01190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
M9Y_RS01195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
M9Y_RS01205	COG0494	nUDIX hydrolase
M9Y_RS01215	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
M9Y_RS01220	COG0483	inositol monophosphate 1-phosphatase activity
M9Y_RS01230	COG0688	phosphatidylethanolamine metabolic process
M9Y_RS01235	COG1183	phosphatidylcholine synthase activity
M9Y_RS01260	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
M9Y_RS01265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
M9Y_RS01270	COG1181	Belongs to the D-alanine--D-alanine ligase family
M9Y_RS01275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
M9Y_RS01285	COG1585	Membrane protein implicated in regulation of membrane protease activity
M9Y_RS01290	COG3474	cytochrome
M9Y_RS01295	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
M9Y_RS01305	COG1530	ribonuclease E activity
M9Y_RS01310	COG1612	heme a metabolic process
M9Y_RS01315	COG0564	pseudouridine synthase activity
M9Y_RS01320	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
M9Y_RS01325	COG0708	Exodeoxyribonuclease III
M9Y_RS01330	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
M9Y_RS01335	COG0022	dehydrogenase e1 component
M9Y_RS01340	COG1217	gtp-binding protein TYPA
M9Y_RS01350	COG0473	3-isopropylmalate dehydrogenase activity
M9Y_RS01355	COG1320	monovalent cation:proton antiporter activity
M9Y_RS01375	COG0723	plastoquinol--plastocyanin reductase activity
M9Y_RS01380	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M9Y_RS01385	COG2857	Cytochrome c1
M9Y_RS01385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
M9Y_RS01390	COG0071	Belongs to the small heat shock protein (HSP20) family
M9Y_RS01400	COG0481	GTPase activity
M9Y_RS01425	COG0772	Belongs to the SEDS family
M9Y_RS01445	COG2111	Na H antiporter
M9Y_RS01445	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9Y_RS01450	COG0651	ATP synthesis coupled electron transport
M9Y_RS01455	COG1006	Multisubunit Na H antiporter MnhC subunit
M9Y_RS01475	COG3736	Type IV secretory pathway, component VirB8
M9Y_RS01480	COG3504	Conjugal transfer protein
M9Y_RS01485	COG2948	multi-organism process
M9Y_RS01510	COG0546	phosphoglycolate phosphatase activity
M9Y_RS01520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
M9Y_RS01525	COG0698	ribose 5-phosphate isomerase
M9Y_RS01535	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
M9Y_RS01540	COG0823	Involved in the tonB-independent uptake of proteins
M9Y_RS01545	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M9Y_RS01550	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
M9Y_RS01560	COG0482	sulfurtransferase activity
M9Y_RS01565	COG0531	amino acid
M9Y_RS01570	COG0124	histidyl-tRNA synthetase
M9Y_RS01590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9Y_RS01595	COG0477	Major facilitator Superfamily
M9Y_RS01610	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
M9Y_RS01615	COG0537	adenosine 5'-monophosphoramidase activity
M9Y_RS01625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
M9Y_RS01630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
M9Y_RS01635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
M9Y_RS01640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
M9Y_RS01645	COG1965	Belongs to the frataxin family
M9Y_RS01650	COG1268	BioY protein
M9Y_RS01655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9Y_RS01660	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
M9Y_RS01660	COG1754	DNA topoisomerase type I activity
M9Y_RS01665	COG0450	alkyl hydroperoxide reductase
M9Y_RS01680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
M9Y_RS01695	COG1086	Polysaccharide biosynthesis protein
M9Y_RS01710	COG0297	glycogen (starch) synthase activity
M9Y_RS01725	COG1216	Glycosyl transferase, family 2
M9Y_RS01750	COG0438	transferase activity, transferring glycosyl groups
M9Y_RS01755	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
M9Y_RS01760	COG0109	protoheme IX farnesyltransferase activity
M9Y_RS01770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
M9Y_RS01780	COG1722	exodeoxyribonuclease VII activity
M9Y_RS01785	COG2094	Belongs to the DNA glycosylase MPG family
M9Y_RS01790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
M9Y_RS01795	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
M9Y_RS01800	COG0649	NAD binding
M9Y_RS01805	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS01810	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS01815	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS01820	COG3307	-O-antigen
M9Y_RS01825	COG4765	Protein conserved in bacteria
M9Y_RS01835	COG4974	Belongs to the 'phage' integrase family
M9Y_RS01855	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
M9Y_RS01860	COG0815	Transfers the fatty acyl group on membrane lipoproteins
M9Y_RS01865	COG2984	ABC transporter substrate binding protein
M9Y_RS01870	COG4120	Belongs to the binding-protein-dependent transport system permease family
M9Y_RS01875	COG1122	ATPase activity
M9Y_RS01885	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
M9Y_RS01890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
M9Y_RS01900	COG0281	malic enzyme
M9Y_RS01900	COG0280	phosphate acetyltransferase
M9Y_RS01910	COG0477	Major facilitator Superfamily
M9Y_RS01915	COG0039	L-malate dehydrogenase activity
M9Y_RS01920	COG3202	ADP transmembrane transporter activity
M9Y_RS01925	COG0504	CTP synthase activity
M9Y_RS01930	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
M9Y_RS01945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9Y_RS01950	COG0302	gtp cyclohydrolase
M9Y_RS01955	COG0442	prolyl-tRNA aminoacylation
M9Y_RS01965	COG0632	four-way junction helicase activity
M9Y_RS01970	COG2255	four-way junction helicase activity
M9Y_RS01975	COG1132	(ABC) transporter
M9Y_RS01985	COG1686	Belongs to the peptidase S11 family
M9Y_RS01990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
M9Y_RS02000	COG2917	probably involved in intracellular septation
M9Y_RS02010	COG4633	Protein conserved in bacteria
M9Y_RS02015	COG0545	Peptidyl-prolyl cis-trans isomerase
M9Y_RS02020	COG3485	protocatechuate 3,4-dioxygenase
M9Y_RS02030	COG0616	signal peptide processing
M9Y_RS02030	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
M9Y_RS02035	COG0756	dUTP diphosphatase activity
M9Y_RS02050	COG1619	proteins homologs of microcin C7 resistance protein MccF
M9Y_RS02055	COG2887	Belongs to the helicase family. UvrD subfamily
M9Y_RS02060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M9Y_RS02065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
M9Y_RS02070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
M9Y_RS02075	COG0739	heme binding
M9Y_RS02080	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
M9Y_RS02090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
M9Y_RS02100	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
M9Y_RS02115	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
M9Y_RS02120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M9Y_RS02125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
M9Y_RS02130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9Y_RS02130	COG0072	phenylalanine-tRNA ligase activity
M9Y_RS02135	COG0592	DNA-directed DNA polymerase activity
M9Y_RS02145	COG0495	leucyl-tRNA aminoacylation
M9Y_RS02155	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
M9Y_RS02160	COG0575	Belongs to the CDS family
M9Y_RS02165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
M9Y_RS02170	COG2205	protein histidine kinase activity
M9Y_RS02175	COG0745	RESPONSE REGULATOR receiver
M9Y_RS02180	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
M9Y_RS02185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
M9Y_RS02190	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
M9Y_RS02200	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
M9Y_RS02205	COG0045	succinate-CoA ligase (ADP-forming) activity
M9Y_RS02210	COG4395	Tim44
M9Y_RS02215	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
M9Y_RS02220	COG1238	metal cluster binding
M9Y_RS02225	COG1714	RDD family
M9Y_RS02230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
M9Y_RS02240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
M9Y_RS02250	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
M9Y_RS02260	COG0596	Alpha beta hydrolase
M9Y_RS02265	COG0492	ferredoxin-NADP+ reductase activity
M9Y_RS02270	COG0463	Glycosyl transferase, family 2
M9Y_RS02275	COG0210	DNA helicase
M9Y_RS02285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
M9Y_RS02290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
M9Y_RS02300	COG1304	FMN binding
M9Y_RS02310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
M9Y_RS02315	COG0217	transcriptional regulatory protein
M9Y_RS02320	COG0257	Belongs to the bacterial ribosomal protein bL36 family
M9Y_RS02335	COG2226	methyltransferase
M9Y_RS02340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9Y_RS02345	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
M9Y_RS02350	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
M9Y_RS02360	COG0354	folic acid binding
M9Y_RS02365	COG2205	protein histidine kinase activity
M9Y_RS02370	COG0181	hydroxymethylbilane synthase activity
M9Y_RS02380	COG0180	Tryptophanyl-tRNA synthetase
M9Y_RS02390	COG5622	Protein required for attachment to host cells
M9Y_RS02395	COG2945	thiolester hydrolase activity
M9Y_RS02400	COG3071	HemY protein
M9Y_RS02405	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS02410	COG1587	Uroporphyrinogen-III synthase
M9Y_RS02415	COG2807	transmembrane transport
M9Y_RS02425	COG3202	ADP transmembrane transporter activity
M9Y_RS02435	COG0142	geranyltranstransferase activity
M9Y_RS02450	COG0006	proline dipeptidase activity
M9Y_RS02455	COG0531	amino acid
M9Y_RS02460	COG0316	Belongs to the HesB IscA family
M9Y_RS02465	COG0822	iron-sulfur transferase activity
M9Y_RS02475	COG1104	cysteine desulfurase activity
M9Y_RS02480	COG1959	2 iron, 2 sulfur cluster binding
M9Y_RS02495	COG0574	Belongs to the PEP-utilizing enzyme family
M9Y_RS02495	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
M9Y_RS02500	COG0235	Class ii aldolase
M9Y_RS02505	COG1496	oxidoreductase activity
M9Y_RS02515	COG1295	ribonuclease BN
M9Y_RS02520	COG1396	sequence-specific DNA binding
M9Y_RS02525	COG5183	chlorophyll binding
M9Y_RS02530	COG3202	ADP transmembrane transporter activity
M9Y_RS02535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
M9Y_RS02540	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
M9Y_RS02545	COG1185	polyribonucleotide nucleotidyltransferase activity
M9Y_RS02550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
M9Y_RS02550	COG0517	IMP dehydrogenase activity
M9Y_RS02555	COG5375	Protein conserved in bacteria
M9Y_RS02560	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
M9Y_RS02565	COG1137	ATPase activity
M9Y_RS02575	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
M9Y_RS02580	COG1357	PFAM Pentapeptide repeats (8 copies)
M9Y_RS02595	COG0492	ferredoxin-NADP+ reductase activity
M9Y_RS02600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
M9Y_RS02605	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
M9Y_RS02625	COG0740	serine-type endopeptidase activity
M9Y_RS02630	COG0539	negative regulation of cytoplasmic translation
M9Y_RS02635	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
M9Y_RS02645	COG0776	regulation of translation
M9Y_RS02650	COG0616	signal peptide processing
M9Y_RS02655	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
M9Y_RS02670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
M9Y_RS02675	COG0508	dehydrogenase complex catalyzes the overall conversion of
M9Y_RS02680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
M9Y_RS02685	COG5346	Predicted membrane protein (DUF2335)
M9Y_RS02700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
M9Y_RS02705	COG0285	dihydrofolate synthase activity
M9Y_RS02715	COG1007	ATP synthesis coupled electron transport
M9Y_RS02725	COG0113	porphobilinogen synthase activity
M9Y_RS02730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
M9Y_RS02735	COG0163	prenyltransferase activity
M9Y_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
M9Y_RS02750	COG1187	pseudouridine synthase activity
M9Y_RS02755	COG0742	ribosomal rna small subunit methyltransferase
M9Y_RS02760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
M9Y_RS02770	COG1381	Involved in DNA repair and RecF pathway recombination
M9Y_RS02775	COG1214	PFAM Peptidase M22, glycoprotease
M9Y_RS02785	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
M9Y_RS02790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M9Y_RS02790	COG0195	Participates in both transcription termination and antitermination
M9Y_RS02795	COG0779	Required for maturation of 30S ribosomal subunits
M9Y_RS02805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
M9Y_RS02820	COG1250	3-hydroxyacyl-CoA dehydrogenase
M9Y_RS02820	COG1024	Enoyl-CoA hydratase
M9Y_RS02830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
M9Y_RS02840	COG2204	response regulator
M9Y_RS02870	COG5462	secreted (periplasmic) protein
M9Y_RS02875	COG0275	rRNA processing
M9Y_RS02880	COG2001	Belongs to the MraZ family
M9Y_RS02890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
M9Y_RS02895	COG0322	excinuclease ABC activity
M9Y_RS02900	COG2847	Copper chaperone PCu(A)C
M9Y_RS02915	COG0653	protein targeting
M9Y_RS02920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
M9Y_RS02925	COG0736	holo-[acyl-carrier-protein] synthase activity
M9Y_RS02930	COG1758	RNA polymerase activity
M9Y_RS02935	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
M9Y_RS02940	COG0187	DNA topoisomerase II activity
M9Y_RS02955	COG2239	Acts as a magnesium transporter
M9Y_RS02965	COG1862	Preprotein translocase
M9Y_RS02970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
M9Y_RS02975	COG1999	signal sequence binding
M9Y_RS02980	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
M9Y_RS02985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
M9Y_RS02990	COG0728	peptidoglycan biosynthetic process
M9Y_RS03000	COG1917	Cupin 2, conserved barrel domain protein
M9Y_RS03005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
M9Y_RS03010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9Y_RS03015	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
M9Y_RS03020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
M9Y_RS03025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
M9Y_RS03035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
M9Y_RS03040	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9Y_RS03050	COG2814	Major facilitator Superfamily
M9Y_RS03055	COG0012	GTP binding
M9Y_RS03060	COG0193	aminoacyl-tRNA hydrolase activity
M9Y_RS03065	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
M9Y_RS03070	COG0602	queuosine metabolic process
M9Y_RS03075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
M9Y_RS03080	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
M9Y_RS03085	COG0230	Belongs to the bacterial ribosomal protein bL34 family
M9Y_RS03090	COG0594	ribonuclease P activity
M9Y_RS03105	COG5000	phosphorelay sensor kinase activity
M9Y_RS03110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
M9Y_RS03120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
M9Y_RS03125	COG4770	biotin carboxylase activity
M9Y_RS03130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
M9Y_RS03140	COG1108	ABC-type Mn2 Zn2 transport systems permease components
M9Y_RS03145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
M9Y_RS03150	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
M9Y_RS03160	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
M9Y_RS03165	COG0459	protein refolding
M9Y_RS03170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
M9Y_RS03175	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
M9Y_RS03180	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
M9Y_RS03185	COG0628	permease
M9Y_RS03190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
M9Y_RS03200	COG0268	Binds directly to 16S ribosomal RNA
M9Y_RS03205	COG0203	ribosomal protein L17
M9Y_RS03210	COG0202	RNA polymerase activity
M9Y_RS03215	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
M9Y_RS03220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
M9Y_RS03225	COG0563	adenylate kinase activity
M9Y_RS03230	COG0201	protein transport
M9Y_RS03235	COG0200	Binds to the 23S rRNA
M9Y_RS03240	COG1841	ribosomal large subunit assembly
M9Y_RS03245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
M9Y_RS03250	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
M9Y_RS03255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
M9Y_RS03260	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
M9Y_RS03265	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
M9Y_RS03270	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
M9Y_RS03275	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
M9Y_RS03280	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
M9Y_RS03285	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
M9Y_RS03290	COG0255	Belongs to the universal ribosomal protein uL29 family
M9Y_RS03295	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
M9Y_RS03300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
M9Y_RS03305	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
M9Y_RS03310	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
M9Y_RS03315	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
M9Y_RS03320	COG0089	rRNA binding
M9Y_RS03325	COG0088	Forms part of the polypeptide exit tunnel
M9Y_RS03330	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
M9Y_RS03335	COG0051	transcription antitermination factor activity, RNA binding
M9Y_RS03340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
M9Y_RS03355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
M9Y_RS03360	COG0114	fumarate hydratase activity
M9Y_RS03365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
M9Y_RS03370	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
M9Y_RS03375	COG2271	Major facilitator Superfamily
M9Y_RS03380	COG0513	Belongs to the DEAD box helicase family
M9Y_RS03385	COG1278	Cold shock
M9Y_RS03400	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
M9Y_RS03410	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
M9Y_RS03415	COG1570	exodeoxyribonuclease VII activity
M9Y_RS03420	COG0708	Exodeoxyribonuclease III
M9Y_RS03425	COG1160	GTP binding
M9Y_RS03435	COG2226	methyltransferase
M9Y_RS03445	COG0084	hydrolase, TatD family'
M9Y_RS03450	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
M9Y_RS03455	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
M9Y_RS03460	COG0477	Major facilitator Superfamily
M9Y_RS03465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
M9Y_RS03470	COG0525	valine-tRNA ligase activity
M9Y_RS03475	COG3475	LICD family
M9Y_RS03480	COG3475	LICD family
M9Y_RS03485	COG1322	Protein conserved in bacteria
M9Y_RS03495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
M9Y_RS03505	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
M9Y_RS03515	COG1132	(ABC) transporter
M9Y_RS03525	COG2814	Major facilitator Superfamily
M9Y_RS03535	COG1136	(ABC) transporter
M9Y_RS03545	COG4536	flavin adenine dinucleotide binding
M9Y_RS03550	COG1138	Cytochrome C-type biogenesis protein
M9Y_RS03555	COG4625	pathogenesis
M9Y_RS03570	COG0776	regulation of translation
M9Y_RS03600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
M9Y_RS03610	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
M9Y_RS03615	COG0666	response to abiotic stimulus
M9Y_RS03650	COG1663	tetraacyldisaccharide 4'-kinase activity
M9Y_RS03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
M9Y_RS03660	COG0343	queuine tRNA-ribosyltransferase activity
M9Y_RS03680	COG3761	NADH ubiquinone oxidoreductase 17.2 kD subunit
M9Y_RS03685	COG0328	RNA-DNA hybrid ribonuclease activity
M9Y_RS03700	COG0237	dephospho-CoA kinase activity
M9Y_RS03705	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
M9Y_RS03710	COG3346	SURF1 family
M9Y_RS03715	COG1074	ATP-dependent DNA helicase activity
M9Y_RS03720	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
M9Y_RS03740	COG3202	ADP transmembrane transporter activity
M9Y_RS03745	COG1253	flavin adenine dinucleotide binding
M9Y_RS03750	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
M9Y_RS03755	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
M9Y_RS03760	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
M9Y_RS03765	COG0400	carboxylic ester hydrolase activity
M9Y_RS03770	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
M9Y_RS03775	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
M9Y_RS03785	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
M9Y_RS03790	COG0683	leucine binding
M9Y_RS03795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
M9Y_RS03800	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
M9Y_RS03805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
M9Y_RS03810	COG0211	Belongs to the bacterial ribosomal protein bL27 family
M9Y_RS03815	COG0527	aspartate kinase activity
M9Y_RS03825	COG0477	Major facilitator Superfamily
M9Y_RS03830	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
M9Y_RS03840	COG1426	Protein conserved in bacteria
M9Y_RS03845	COG2902	Dehydrogenase
M9Y_RS03850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
M9Y_RS03860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
M9Y_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
M9Y_RS03870	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
M9Y_RS03875	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
M9Y_RS03880	COG0194	GDP metabolic process
M9Y_RS03910	COG2885	chlorophyll binding
M9Y_RS03915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
M9Y_RS03920	COG0333	Belongs to the bacterial ribosomal protein bL32 family
M9Y_RS03930	COG0552	protein localization to endoplasmic reticulum
M9Y_RS03935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9Y_RS03935	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
M9Y_RS03945	COG0587	DNA-directed DNA polymerase activity
M9Y_RS03950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
M9Y_RS03960	COG2814	Major facilitator Superfamily
M9Y_RS03965	COG0805	protein transport
M9Y_RS03970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
M9Y_RS03975	COG3451	type IV secretory pathway VirB4
M9Y_RS03985	COG0861	Integral membrane protein TerC family
M9Y_RS03990	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M9Y_RS03995	COG4797	methyltransferase
M9Y_RS03995	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
M9Y_RS04000	COG0839	Belongs to the complex I subunit 6 family
M9Y_RS04005	COG0713	ATP synthesis coupled electron transport
M9Y_RS04010	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
M9Y_RS04015	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS04020	COG4133	protoheme IX ABC transporter activity
M9Y_RS04025	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
M9Y_RS04030	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
M9Y_RS04035	COG1034	ATP synthesis coupled electron transport
M9Y_RS04045	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
M9Y_RS04050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
M9Y_RS04055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
M9Y_RS04060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
M9Y_RS04065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
M9Y_RS04070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
M9Y_RS04075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
M9Y_RS04080	COG0783	Belongs to the Dps family
M9Y_RS04085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
M9Y_RS04090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
M9Y_RS04105	COG0799	negative regulation of ribosome biogenesis
M9Y_RS04110	COG0271	Belongs to the BolA IbaG family
M9Y_RS04120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
M9Y_RS04125	COG0424	maF-like protein
M9Y_RS04135	COG4974	Belongs to the 'phage' integrase family
M9Y_RS04145	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
M9Y_RS04150	COG3243	poly(R)-hydroxyalkanoic acid synthase
M9Y_RS04155	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
M9Y_RS04165	COG1674	ftsk spoiiie
M9Y_RS04175	COG0024	Methionine aminopeptidase
M9Y_RS04185	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
M9Y_RS04200	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
M9Y_RS04205	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
M9Y_RS04210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
M9Y_RS04215	COG0590	tRNA wobble adenosine to inosine editing
M9Y_RS04220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
M9Y_RS04225	COG4520	surface antigen
M9Y_RS04230	COG1121	(ABC) transporter
M9Y_RS04235	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
M9Y_RS04240	COG0629	single-stranded DNA binding
M9Y_RS04255	COG1872	DUF167
M9Y_RS04260	COG0326	Molecular chaperone. Has ATPase activity
M9Y_RS04265	COG0156	8-amino-7-oxononanoate synthase activity
M9Y_RS04270	COG0544	peptidyl-prolyl cis-trans isomerase activity
M9Y_RS04275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
M9Y_RS04280	COG0372	Belongs to the citrate synthase family
M9Y_RS04285	COG1573	uracil-dna glycosylase
M9Y_RS04290	COG0564	pseudouridine synthase activity
M9Y_RS04295	COG0220	tRNA (guanine-N7-)-methyltransferase activity
M9Y_RS04295	COG2890	protein-(glutamine-N5) methyltransferase activity
M9Y_RS04300	COG0009	L-threonylcarbamoyladenylate synthase
M9Y_RS04305	COG0751	glycine-tRNA ligase activity
M9Y_RS04310	COG0752	glycyl-tRNA synthetase alpha subunit
M9Y_RS04315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
M9Y_RS04320	COG0477	Major facilitator Superfamily
M9Y_RS04340	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
M9Y_RS04345	COG0101	tRNA pseudouridine synthase activity
M9Y_RS04350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
M9Y_RS04355	COG0358	DNA primase activity
M9Y_RS04360	COG0170	dolichyl monophosphate biosynthetic process
M9Y_RS04365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
M9Y_RS04370	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M9Y_RS04375	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
M9Y_RS04380	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
M9Y_RS04385	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
M9Y_RS04390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
M9Y_RS04395	COG3577	Aspartyl protease
M9Y_RS04400	COG1126	abc transporter atp-binding protein
M9Y_RS04415	COG0795	lipopolysaccharide-transporting ATPase activity
M9Y_RS04420	COG2927	DNA polymerase III (CHI subunit)
M9Y_RS04430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
M9Y_RS04435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
M9Y_RS04440	COG0321	lipoyl(octanoyl) transferase activity
M9Y_RS04450	COG0228	four-way junction DNA binding
M9Y_RS04455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
M9Y_RS04460	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
M9Y_RS04465	COG0477	Major facilitator Superfamily
M9Y_RS04470	COG0408	coproporphyrinogen oxidase activity
M9Y_RS04475	COG1981	membrane
M9Y_RS04480	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
M9Y_RS04485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III