locus-tag	class	description
E0E05_RS00010	COG3002	Belongs to the UPF0753 family
E0E05_RS00015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0E05_RS00025	COG3842	ATPase activity
E0E05_RS00030	COG4821	SIS domain
E0E05_RS00035	COG2188	Transcriptional regulator
E0E05_RS00040	COG1940	carbohydrate kinase activity
E0E05_RS00045	COG0395	ABC-type sugar transport system, permease component
E0E05_RS00050	COG1175	transmembrane transport
E0E05_RS00055	COG1653	transport
E0E05_RS00070	COG1228	amidohydrolase
E0E05_RS00080	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E0E05_RS00140	COG0745	RESPONSE REGULATOR receiver
E0E05_RS00150	COG0156	8-amino-7-oxononanoate synthase activity
E0E05_RS00155	COG3300	MHYT domain
E0E05_RS00155	COG5001	Diguanylate cyclase
E0E05_RS00165	COG0339	signal peptide processing
E0E05_RS00185	COG2917	probably involved in intracellular septation
E0E05_RS00190	COG0552	protein localization to endoplasmic reticulum
E0E05_RS00195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0E05_RS00200	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E0E05_RS00225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E0E05_RS00245	COG0228	four-way junction DNA binding
E0E05_RS00260	COG2845	Protein of unknown function (DUF459)
E0E05_RS00265	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E0E05_RS00270	COG0346	lactoylglutathione lyase activity
E0E05_RS00275	COG0039	L-malate dehydrogenase activity
E0E05_RS00285	COG0045	succinate-CoA ligase (ADP-forming) activity
E0E05_RS00305	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0E05_RS00345	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E0E05_RS00355	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0E05_RS00360	COG1329	Transcriptional regulator
E0E05_RS00365	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E0E05_RS00385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0E05_RS00390	COG0165	Argininosuccinate lyase
E0E05_RS00400	COG0019	diaminopimelate decarboxylase activity
E0E05_RS00415	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
E0E05_RS00440	COG0488	(ABC) transporter
E0E05_RS00450	COG0183	Belongs to the thiolase family
E0E05_RS00460	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E0E05_RS00470	COG2902	Dehydrogenase
E0E05_RS00490	COG4974	Belongs to the 'phage' integrase family
E0E05_RS00500	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E0E05_RS00505	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
E0E05_RS00510	COG4536	flavin adenine dinucleotide binding
E0E05_RS00535	COG1598	PFAM Uncharacterised protein family UPF0150
E0E05_RS00550	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
E0E05_RS00555	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E0E05_RS00575	COG2226	methyltransferase
E0E05_RS00585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0E05_RS00590	COG0287	Prephenate dehydrogenase
E0E05_RS00620	COG2884	Cell division ATP-binding protein ftsE
E0E05_RS00630	COG0671	phosphoesterase, PA-phosphatase related
E0E05_RS00635	COG0137	argininosuccinate synthase activity
E0E05_RS00670	COG0066	3-isopropylmalate dehydratase activity
E0E05_RS00690	COG0251	oxidation-reduction process
E0E05_RS00700	COG0473	3-isopropylmalate dehydrogenase activity
E0E05_RS00715	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E0E05_RS00725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0E05_RS00745	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS00750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E0E05_RS00760	COG0142	geranyltranstransferase activity
E0E05_RS00765	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E0E05_RS00770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E0E05_RS00785	COG0495	leucyl-tRNA aminoacylation
E0E05_RS00810	COG0357	Ribosomal RNA small subunit methyltransferase G
E0E05_RS00820	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E0E05_RS00825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E0E05_RS00830	COG1981	membrane
E0E05_RS00835	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
E0E05_RS00840	COG0424	maF-like protein
E0E05_RS00845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E0E05_RS00850	COG0237	dephospho-CoA kinase activity
E0E05_RS00855	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E0E05_RS00860	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
E0E05_RS00875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E0E05_RS00885	COG1396	sequence-specific DNA binding
E0E05_RS00890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E0E05_RS00905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
E0E05_RS00910	COG0131	Imidazoleglycerol-phosphate dehydratase
E0E05_RS00920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E0E05_RS00925	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E0E05_RS00940	COG0140	phosphoribosyl-ATP diphosphatase activity
E0E05_RS00945	COG1072	(Pantothenic acid kinase))
E0E05_RS00955	COG1294	oxidase, subunit
E0E05_RS00960	COG1271	oxidase subunit
E0E05_RS00965	COG1032	radical SAM domain protein
E0E05_RS00975	COG0513	Belongs to the DEAD box helicase family
E0E05_RS00985	COG5425	PFAM Usg family protein
E0E05_RS01010	COG0667	Aldo Keto reductase
E0E05_RS01020	COG2124	cytochrome p450
E0E05_RS01030	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E0E05_RS01035	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0E05_RS01055	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS01065	COG0673	inositol 2-dehydrogenase activity
E0E05_RS01070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS01080	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E0E05_RS01090	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E0E05_RS01095	COG2989	Protein conserved in bacteria
E0E05_RS01100	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0E05_RS01100	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0E05_RS01105	COG0583	DNA-binding transcription factor activity
E0E05_RS01115	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
E0E05_RS01120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0E05_RS01120	COG3153	acetyltransferase
E0E05_RS01125	COG1744	ABC transporter substrate-binding protein PnrA-like
E0E05_RS01135	COG2017	converts alpha-aldose to the beta-anomer
E0E05_RS01155	COG0300	oxidoreductase activity
E0E05_RS01165	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0E05_RS01165	COG0475	glutathione-regulated potassium exporter activity
E0E05_RS01220	COG2388	GCN5-related N-acetyl-transferase
E0E05_RS01235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS01240	COG0601	transmembrane transport
E0E05_RS01255	COG1253	flavin adenine dinucleotide binding
E0E05_RS01270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E0E05_RS01290	COG0588	phosphoglycerate mutase activity
E0E05_RS01295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E0E05_RS01300	COG1132	(ABC) transporter
E0E05_RS01305	COG0837	glucose binding
E0E05_RS01310	COG1803	Methylglyoxal synthase
E0E05_RS01315	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
E0E05_RS01350	COG0072	phenylalanine-tRNA ligase activity
E0E05_RS01350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0E05_RS01365	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E0E05_RS01370	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E0E05_RS01375	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E0E05_RS01380	COG2264	protein methyltransferase activity
E0E05_RS01385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E0E05_RS01395	COG3135	benzoate transporter
E0E05_RS01410	COG0135	phosphoribosylanthranilate isomerase activity
E0E05_RS01415	COG0133	tryptophan synthase activity
E0E05_RS01430	COG0159	tryptophan synthase activity
E0E05_RS01435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E0E05_RS01440	COG0285	dihydrofolate synthase activity
E0E05_RS01460	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E0E05_RS01465	COG3178	'Phosphotransferase
E0E05_RS01470	COG2205	protein histidine kinase activity
E0E05_RS01475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
E0E05_RS01480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0E05_RS01495	COG0642	Histidine kinase
E0E05_RS01500	COG0745	RESPONSE REGULATOR receiver
E0E05_RS01505	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E0E05_RS01520	COG1652	LysM domain
E0E05_RS01535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS01540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E0E05_RS01545	COG1420	regulation of RNA biosynthetic process
E0E05_RS01550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
E0E05_RS01560	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E0E05_RS01565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0E05_RS01570	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E0E05_RS01575	COG0792	nuclease activity
E0E05_RS01590	COG0756	dUTP diphosphatase activity
E0E05_RS01600	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
E0E05_RS01615	COG0450	alkyl hydroperoxide reductase
E0E05_RS01620	COG1741	Belongs to the pirin family
E0E05_RS01625	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
E0E05_RS01640	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
E0E05_RS01645	COG2226	methyltransferase
E0E05_RS01650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E0E05_RS01655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E0E05_RS01665	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
E0E05_RS01670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
E0E05_RS01680	COG1079	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS01685	COG1079	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS01695	COG3845	ABC transporter
E0E05_RS01705	COG0471	metal ion transport
E0E05_RS01705	COG3273	potassium ion transport
E0E05_RS01720	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS01720	COG1388	LysM domain
E0E05_RS01725	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS01745	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
E0E05_RS01770	COG0167	dihydroorotate dehydrogenase activity
E0E05_RS01775	COG0534	Mate efflux family protein
E0E05_RS01780	COG0123	including yeast histone deacetylase and acetoin utilization protein
E0E05_RS01790	COG1793	dna ligase
E0E05_RS01800	COG1201	RNA secondary structure unwinding
E0E05_RS01820	COG0730	response to heat
E0E05_RS01830	COG0789	Transcriptional regulator
E0E05_RS01835	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS01850	COG0183	Belongs to the thiolase family
E0E05_RS01860	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0E05_RS01860	COG1024	Enoyl-CoA hydratase
E0E05_RS01875	COG1278	Cold shock
E0E05_RS01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0E05_RS01920	COG0717	Belongs to the dCTP deaminase family
E0E05_RS01945	COG2967	ApaG domain
E0E05_RS01950	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0E05_RS01955	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E0E05_RS01965	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E0E05_RS01970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E0E05_RS01980	COG0745	RESPONSE REGULATOR receiver
E0E05_RS01985	COG0704	Plays a role in the regulation of phosphate uptake
E0E05_RS01990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
E0E05_RS02000	COG0573	inorganic phosphate transmembrane transporter activity
E0E05_RS02010	COG5002	protein histidine kinase activity
E0E05_RS02015	COG2326	polyphosphate kinase activity
E0E05_RS02030	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0E05_RS02060	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
E0E05_RS02085	COG5001	Diguanylate cyclase
E0E05_RS02100	COG1663	tetraacyldisaccharide 4'-kinase activity
E0E05_RS02105	COG1519	Transferase
E0E05_RS02115	COG0483	inositol monophosphate 1-phosphatase activity
E0E05_RS02120	COG0312	modulator of DNA gyrase
E0E05_RS02125	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0E05_RS02125	COG0475	glutathione-regulated potassium exporter activity
E0E05_RS02145	COG0742	ribosomal rna small subunit methyltransferase
E0E05_RS02155	COG0590	tRNA wobble adenosine to inosine editing
E0E05_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS02185	COG0196	riboflavin kinase activity
E0E05_RS02190	COG0156	8-amino-7-oxononanoate synthase activity
E0E05_RS02195	COG1063	alcohol dehydrogenase
E0E05_RS02205	COG0659	secondary active sulfate transmembrane transporter activity
E0E05_RS02210	COG0459	protein refolding
E0E05_RS02215	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E0E05_RS02240	COG0589	response to stress
E0E05_RS02245	COG0625	glutathione transferase activity
E0E05_RS02260	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
E0E05_RS02265	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
E0E05_RS02275	COG0124	histidyl-tRNA synthetase
E0E05_RS02290	COG2818	Glycosylase
E0E05_RS02295	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS02295	COG1388	LysM domain
E0E05_RS02310	COG0247	lactate metabolic process
E0E05_RS02320	COG0277	FAD linked oxidase domain protein
E0E05_RS02325	COG0277	FAD linked oxidase domain protein
E0E05_RS02330	COG0583	DNA-binding transcription factor activity
E0E05_RS02355	COG1304	FMN binding
E0E05_RS02380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0E05_RS02385	COG0174	glutamine synthetase
E0E05_RS02400	COG1570	exodeoxyribonuclease VII activity
E0E05_RS02415	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS02420	COG2205	protein histidine kinase activity
E0E05_RS02435	COG1177	transmembrane transport
E0E05_RS02440	COG1176	ABC-type spermidine putrescine transport system, permease component I
E0E05_RS02445	COG3842	ATPase activity
E0E05_RS02455	COG0174	glutamine synthetase
E0E05_RS02490	COG0471	metal ion transport
E0E05_RS02490	COG3273	potassium ion transport
E0E05_RS02505	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E0E05_RS02515	COG2308	Evidence 4 Homologs of previously reported genes of
E0E05_RS02535	COG0683	leucine binding
E0E05_RS02540	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0E05_RS02540	COG0519	Catalyzes the synthesis of GMP from XMP
E0E05_RS02560	COG0559	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS02600	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
E0E05_RS02635	COG0189	ligase activity
E0E05_RS02655	COG0789	Transcriptional regulator
E0E05_RS02675	COG0129	dihydroxy-acid dehydratase activity
E0E05_RS02680	COG0363	glucosamine-6-phosphate deaminase activity
E0E05_RS02685	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E0E05_RS02695	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS02705	COG0673	inositol 2-dehydrogenase activity
E0E05_RS02715	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
E0E05_RS02745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0E05_RS02750	COG2010	Cytochrome c
E0E05_RS02750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0E05_RS02780	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E0E05_RS02800	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS02805	COG1285	pathogenesis
E0E05_RS02815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS02825	COG0071	Belongs to the small heat shock protein (HSP20) family
E0E05_RS02830	COG4134	Bacterial extracellular solute-binding protein
E0E05_RS02835	COG4135	transport system, permease component
E0E05_RS02840	COG4136	ATPase activity
E0E05_RS02845	COG1643	Atp-dependent helicase
E0E05_RS02855	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E0E05_RS02865	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS02870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
E0E05_RS02880	COG0180	Tryptophanyl-tRNA synthetase
E0E05_RS02885	COG0728	peptidoglycan biosynthetic process
E0E05_RS02890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
E0E05_RS02900	COG0280	phosphate acetyltransferase
E0E05_RS02900	COG0281	malic enzyme
E0E05_RS02915	COG0604	alcohol dehydrogenase
E0E05_RS02925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0E05_RS02935	COG2423	ornithine cyclodeaminase activity
E0E05_RS02950	COG0616	signal peptide processing
E0E05_RS02965	COG1137	ATPase activity
E0E05_RS02970	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E0E05_RS02975	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E0E05_RS02980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
E0E05_RS02990	COG1414	Transcriptional regulator
E0E05_RS03000	COG1175	transmembrane transport
E0E05_RS03010	COG0395	ABC-type sugar transport system, permease component
E0E05_RS03015	COG1486	melibiose metabolic process
E0E05_RS03020	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS03025	COG3734	2-keto-3-deoxy-galactonokinase
E0E05_RS03030	COG0800	Aldolase
E0E05_RS03035	COG3386	PFAM SMP-30 Gluconolaconase
E0E05_RS03050	COG0456	acetyltransferase
E0E05_RS03060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E0E05_RS03065	COG1702	phosphate starvation-inducible protein PhoH
E0E05_RS03075	COG1253	flavin adenine dinucleotide binding
E0E05_RS03080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E0E05_RS03085	COG1396	sequence-specific DNA binding
E0E05_RS03090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E0E05_RS03095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E0E05_RS03105	COG0779	Required for maturation of 30S ribosomal subunits
E0E05_RS03110	COG0195	Participates in both transcription termination and antitermination
E0E05_RS03110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0E05_RS03120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E0E05_RS03130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
E0E05_RS03140	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E0E05_RS03155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E0E05_RS03160	COG1185	polyribonucleotide nucleotidyltransferase activity
E0E05_RS03165	COG2813	Specifically methylates the guanine in position
E0E05_RS03170	COG3300	MHYT domain
E0E05_RS03170	COG5001	Diguanylate cyclase
E0E05_RS03175	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0E05_RS03180	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0E05_RS03185	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0E05_RS03205	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E0E05_RS03205	COG3743	rRNA binding
E0E05_RS03215	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
E0E05_RS03225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E0E05_RS03230	COG0268	Binds directly to 16S ribosomal RNA
E0E05_RS03235	COG1024	Enoyl-CoA hydratase
E0E05_RS03240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
E0E05_RS03245	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
E0E05_RS03285	COG4964	Belongs to the GSP D family
E0E05_RS03320	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0E05_RS03330	COG0791	NLP P60 protein
E0E05_RS03335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0E05_RS03340	COG4172	Belongs to the ABC transporter superfamily
E0E05_RS03355	COG4239	(ABC) transporter, permease
E0E05_RS03360	COG4174	ABC transporter (Permease)
E0E05_RS03370	COG4166	transmembrane transport
E0E05_RS03375	COG3474	cytochrome
E0E05_RS03380	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E0E05_RS03385	COG1605	Chorismate mutase
E0E05_RS03385	COG0077	Prephenate dehydratase
E0E05_RS03390	COG2816	NAD+ diphosphatase activity
E0E05_RS03405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E0E05_RS03410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E0E05_RS03415	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E0E05_RS03450	COG0242	peptide deformylase activity
E0E05_RS03455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E0E05_RS03475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0E05_RS03505	COG2171	N-acyltransferase activity
E0E05_RS03515	COG0583	DNA-binding transcription factor activity
E0E05_RS03525	COG0402	S-adenosylhomocysteine deaminase activity
E0E05_RS03530	COG2358	TRAP transporter, solute receptor (TAXI family
E0E05_RS03550	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0E05_RS03580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0E05_RS03595	COG1609	Transcriptional regulator
E0E05_RS03600	COG1653	transport
E0E05_RS03605	COG1175	transmembrane transport
E0E05_RS03610	COG0395	ABC-type sugar transport system, permease component
E0E05_RS03615	COG0366	Alpha amylase catalytic
E0E05_RS03620	COG3842	ATPase activity
E0E05_RS03630	COG0129	dihydroxy-acid dehydratase activity
E0E05_RS03635	COG3655	Transcriptional regulator
E0E05_RS03655	COG0318	PFAM AMP-dependent synthetase and ligase
E0E05_RS03685	COG1431	PFAM Stem cell self-renewal protein Piwi
E0E05_RS03690	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E0E05_RS03695	COG1061	Type III restriction enzyme res subunit
E0E05_RS03710	COG1002	Type II restriction enzyme, methylase subunits
E0E05_RS03755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
E0E05_RS03820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E0E05_RS03835	COG3920	Histidine kinase
E0E05_RS03835	COG2202	Pas domain
E0E05_RS03850	COG2116	formate transmembrane transporter activity
E0E05_RS03900	COG3920	Histidine kinase
E0E05_RS03930	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0E05_RS03945	COG0784	Response regulator, receiver
E0E05_RS03950	COG3920	Histidine kinase
E0E05_RS04015	COG0530	calcium, potassium:sodium antiporter activity
E0E05_RS04020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E0E05_RS04020	COG0543	2 iron, 2 sulfur cluster binding
E0E05_RS04035	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
E0E05_RS04040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS04045	COG0601	transmembrane transport
E0E05_RS04050	COG0747	negative chemotaxis
E0E05_RS04055	COG0444	Belongs to the ABC transporter superfamily
E0E05_RS04060	COG4608	Belongs to the ABC transporter superfamily
E0E05_RS04065	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E0E05_RS04075	COG2188	Transcriptional regulator
E0E05_RS04080	COG2971	BadF BadG BcrA BcrD
E0E05_RS04085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E0E05_RS04090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
E0E05_RS04100	COG4191	Histidine kinase
E0E05_RS04115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E0E05_RS04120	COG0594	ribonuclease P activity
E0E05_RS04125	COG0706	membrane insertase activity
E0E05_RS04130	COG0110	maltose O-acetyltransferase activity
E0E05_RS04135	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E0E05_RS04140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E0E05_RS04155	COG3963	phosphatidate phosphatase activity
E0E05_RS04165	COG0284	orotidine-5'-phosphate decarboxylase activity
E0E05_RS04200	COG2954	triphosphatase activity
E0E05_RS04215	COG0481	GTPase activity
E0E05_RS04230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
E0E05_RS04265	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0E05_RS04280	COG3685	Protein conserved in bacteria
E0E05_RS04290	COG0519	Catalyzes the synthesis of GMP from XMP
E0E05_RS04290	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0E05_RS04300	COG0625	glutathione transferase activity
E0E05_RS04320	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS04380	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS04400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E0E05_RS04405	COG1522	sequence-specific DNA binding
E0E05_RS04410	COG4166	transmembrane transport
E0E05_RS04415	COG0601	transmembrane transport
E0E05_RS04420	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS04430	COG4608	Belongs to the ABC transporter superfamily
E0E05_RS04440	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E0E05_RS04445	COG1410	methionine synthase
E0E05_RS04445	COG0646	methionine synthase
E0E05_RS04450	COG2890	protein-(glutamine-N5) methyltransferase activity
E0E05_RS04475	COG5598	trimethylamine methyltransferase
E0E05_RS04485	COG0456	acetyltransferase
E0E05_RS04490	COG1280	lysine exporter protein (LysE YggA)
E0E05_RS04500	COG3383	formate dehydrogenase (NAD+) activity
E0E05_RS04530	COG1160	GTP binding
E0E05_RS04545	COG0356	it plays a direct role in the translocation of protons across the membrane
E0E05_RS04550	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0E05_RS04555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E0E05_RS04560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E0E05_RS04580	COG0521	Mo-molybdopterin cofactor biosynthetic process
E0E05_RS04585	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
E0E05_RS04595	COG0142	geranyltranstransferase activity
E0E05_RS04605	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
E0E05_RS04615	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0E05_RS04625	COG0752	glycyl-tRNA synthetase alpha subunit
E0E05_RS04630	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E0E05_RS04635	COG1704	LemA family
E0E05_RS04645	COG0751	glycine-tRNA ligase activity
E0E05_RS04655	COG0009	L-threonylcarbamoyladenylate synthase
E0E05_RS04660	COG0277	FAD linked oxidase domain protein
E0E05_RS04675	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS04680	COG1024	Enoyl-CoA hydratase
E0E05_RS04685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E0E05_RS04690	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
E0E05_RS04700	COG1741	Belongs to the pirin family
E0E05_RS04705	COG1722	exodeoxyribonuclease VII activity
E0E05_RS04710	COG0123	including yeast histone deacetylase and acetoin utilization protein
E0E05_RS04725	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0E05_RS04725	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E0E05_RS04735	COG0588	phosphoglycerate mutase activity
E0E05_RS04740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E0E05_RS04745	COG0484	heat shock protein binding
E0E05_RS04755	COG0259	pyridoxamine-phosphate oxidase activity
E0E05_RS04765	COG0842	Transport permease protein
E0E05_RS04770	COG1131	(ABC) transporter
E0E05_RS04785	COG3706	GGDEF domain
E0E05_RS04810	COG0312	modulator of DNA gyrase
E0E05_RS04820	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E0E05_RS04825	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E0E05_RS04830	COG0109	protoheme IX farnesyltransferase activity
E0E05_RS04835	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E0E05_RS04860	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E0E05_RS04865	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E0E05_RS04870	COG0328	RNA-DNA hybrid ribonuclease activity
E0E05_RS04880	COG0678	peroxiredoxin activity
E0E05_RS04880	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
E0E05_RS04890	COG1678	Uncharacterized ACR, COG1678
E0E05_RS04905	COG0612	Peptidase, M16
E0E05_RS04920	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E0E05_RS04945	COG2983	Belongs to the UPF0260 family
E0E05_RS04965	COG2968	Membrane
E0E05_RS04990	COG0175	sulfate reduction
E0E05_RS04995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E0E05_RS05005	COG1648	precorrin-2 dehydrogenase activity
E0E05_RS05005	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E0E05_RS05010	COG0156	8-amino-7-oxononanoate synthase activity
E0E05_RS05015	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0E05_RS05020	COG2814	Major facilitator Superfamily
E0E05_RS05025	COG2267	carboxylic ester hydrolase activity
E0E05_RS05045	COG0583	DNA-binding transcription factor activity
E0E05_RS05050	COG0492	ferredoxin-NADP+ reductase activity
E0E05_RS05055	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E0E05_RS05085	COG0505	Belongs to the CarA family
E0E05_RS05095	COG0358	DNA primase activity
E0E05_RS05100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0E05_RS05120	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E0E05_RS05125	COG0432	Pfam Uncharacterised protein family UPF0047
E0E05_RS05140	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E0E05_RS05145	COG1196	nuclear chromosome segregation
E0E05_RS05150	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0E05_RS05150	COG0574	Belongs to the PEP-utilizing enzyme family
E0E05_RS05175	COG2080	2 iron, 2 sulfur cluster binding
E0E05_RS05180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E0E05_RS05185	COG1218	3'(2'),5'-bisphosphate nucleotidase
E0E05_RS05190	COG0175	sulfate reduction
E0E05_RS05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0E05_RS05240	COG0433	COG0433 Predicted ATPase
E0E05_RS05245	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS05245	COG1388	LysM domain
E0E05_RS05255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0E05_RS05260	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E0E05_RS05270	COG2010	Cytochrome c
E0E05_RS05290	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0E05_RS05295	COG2111	Na H antiporter
E0E05_RS05295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E0E05_RS05300	COG2111	Na H antiporter
E0E05_RS05305	COG1006	Multisubunit Na H antiporter MnhC subunit
E0E05_RS05310	COG0651	ATP synthesis coupled electron transport
E0E05_RS05315	COG1863	multisubunit Na H antiporter MnhE subunit
E0E05_RS05320	COG2212	antiporter activity
E0E05_RS05325	COG1320	monovalent cation:proton antiporter activity
E0E05_RS05350	COG2166	iron-sulfur cluster assembly
E0E05_RS05360	COG2205	protein histidine kinase activity
E0E05_RS05370	COG3409	Peptidoglycan-binding domain 1 protein
E0E05_RS05370	COG3429	Glucose-6-phosphate dehydrogenase subunit
E0E05_RS05400	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E0E05_RS05415	COG4695	Portal protein
E0E05_RS05515	COG4235	cytochrome complex assembly
E0E05_RS05520	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
E0E05_RS05525	COG1138	Cytochrome C-type biogenesis protein
E0E05_RS05530	COG3088	subunit of a heme lyase
E0E05_RS05540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0E05_RS05545	COG0745	RESPONSE REGULATOR receiver
E0E05_RS05550	COG2205	protein histidine kinase activity
E0E05_RS05555	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E0E05_RS05565	COG2202	Pas domain
E0E05_RS05565	COG2205	protein histidine kinase activity
E0E05_RS05570	COG0308	aminopeptidase N
E0E05_RS05595	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
E0E05_RS05610	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E0E05_RS05615	COG1063	alcohol dehydrogenase
E0E05_RS05640	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E0E05_RS05645	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0E05_RS05670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E0E05_RS05680	COG0625	glutathione transferase activity
E0E05_RS05700	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E0E05_RS05710	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E0E05_RS05770	COG0582	viral genome integration into host DNA
E0E05_RS05840	COG1802	Transcriptional regulator
E0E05_RS05845	COG1902	pentaerythritol trinitrate reductase activity
E0E05_RS05845	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0E05_RS05870	COG0583	DNA-binding transcription factor activity
E0E05_RS05880	COG0583	DNA-binding transcription factor activity
E0E05_RS05890	COG0697	spore germination
E0E05_RS05900	COG1522	sequence-specific DNA binding
E0E05_RS05930	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E0E05_RS05935	COG2218	PFAM glutamate synthase alpha subunit domain protein
E0E05_RS05940	COG0069	glutamate synthase activity
E0E05_RS05945	COG0174	glutamine synthetase
E0E05_RS05965	COG1653	transport
E0E05_RS05985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS05990	COG3119	arylsulfatase activity
E0E05_RS05995	COG0006	proline dipeptidase activity
E0E05_RS06000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0E05_RS06005	COG3485	protocatechuate 3,4-dioxygenase
E0E05_RS06015	COG4177	L-phenylalanine transmembrane transporter activity
E0E05_RS06025	COG0410	ABC transporter
E0E05_RS06030	COG1137	ATPase activity
E0E05_RS06055	COG3485	protocatechuate 3,4-dioxygenase
E0E05_RS06065	COG0405	Gamma-glutamyltransferase
E0E05_RS06075	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
E0E05_RS06100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0E05_RS06105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0E05_RS06105	COG1321	iron dependent repressor
E0E05_RS06110	COG1121	(ABC) transporter
E0E05_RS06115	COG0803	Belongs to the bacterial solute-binding protein 9 family
E0E05_RS06120	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E0E05_RS06125	COG2514	catechol 2,3-dioxygenase activity
E0E05_RS06140	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS06145	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E0E05_RS06170	COG4974	Belongs to the 'phage' integrase family
E0E05_RS06175	COG0741	lytic transglycosylase activity
E0E05_RS06185	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E0E05_RS06190	COG1573	uracil-dna glycosylase
E0E05_RS06200	COG1758	RNA polymerase activity
E0E05_RS06210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E0E05_RS06220	COG0736	holo-[acyl-carrier-protein] synthase activity
E0E05_RS06225	COG0681	Belongs to the peptidase S26 family
E0E05_RS06230	COG0571	ribonuclease III activity
E0E05_RS06235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E0E05_RS06240	COG1381	Involved in DNA repair and RecF pathway recombination
E0E05_RS06250	COG1280	lysine exporter protein (LysE YggA)
E0E05_RS06255	COG0431	NADPH-dependent FMN reductase
E0E05_RS06270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
E0E05_RS06280	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E0E05_RS06300	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
E0E05_RS06305	COG0354	folic acid binding
E0E05_RS06310	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0E05_RS06360	COG0215	cysteine-tRNA ligase activity
E0E05_RS06370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0E05_RS06375	COG2962	Rard protein
E0E05_RS06395	COG5265	(ABC) transporter
E0E05_RS06405	COG0688	phosphatidylethanolamine metabolic process
E0E05_RS06410	COG1183	phosphatidylcholine synthase activity
E0E05_RS06420	COG4221	oxidoreductase activity
E0E05_RS06425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E0E05_RS06440	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E0E05_RS06455	COG0359	binds to the 23S rRNA
E0E05_RS06470	COG0360	Binds together with S18 to 16S ribosomal RNA
E0E05_RS06520	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E0E05_RS06530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0E05_RS06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0E05_RS06540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E0E05_RS06545	COG1561	YicC-like family, N-terminal region
E0E05_RS06550	COG0194	GDP metabolic process
E0E05_RS06555	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E0E05_RS06560	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E0E05_RS06585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E0E05_RS06600	COG0488	(ABC) transporter
E0E05_RS06605	COG0105	UTP biosynthetic process
E0E05_RS06615	COG1272	protein, Hemolysin III
E0E05_RS06620	COG2239	Acts as a magnesium transporter
E0E05_RS06625	COG0314	molybdopterin synthase activity
E0E05_RS06635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E0E05_RS06640	COG0322	excinuclease ABC activity
E0E05_RS06645	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS06650	COG0530	calcium, potassium:sodium antiporter activity
E0E05_RS06675	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0E05_RS06680	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E0E05_RS06690	COG0628	permease
E0E05_RS06700	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E0E05_RS06710	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
E0E05_RS06720	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E0E05_RS06750	COG2226	methyltransferase
E0E05_RS06755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0E05_RS06775	COG1280	lysine exporter protein (LysE YggA)
E0E05_RS06805	COG3038	cytochrome b561
E0E05_RS06835	COG3023	N-Acetylmuramoyl-L-alanine amidase
E0E05_RS06855	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E0E05_RS06860	COG1970	mechanosensitive ion channel activity
E0E05_RS06865	COG2198	Histidine kinase
E0E05_RS06865	COG2205	protein histidine kinase activity
E0E05_RS06865	COG0784	Response regulator, receiver
E0E05_RS06870	COG3757	hydrolase, family 25
E0E05_RS06875	COG0519	Catalyzes the synthesis of GMP from XMP
E0E05_RS06875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E0E05_RS06900	COG4989	oxidoreductase activity
E0E05_RS06905	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E0E05_RS06920	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E0E05_RS06930	COG0113	porphobilinogen synthase activity
E0E05_RS06940	COG1846	Transcriptional regulator
E0E05_RS06950	COG2989	Protein conserved in bacteria
E0E05_RS06955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E0E05_RS06960	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
E0E05_RS06965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0E05_RS06965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E0E05_RS06975	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E0E05_RS06980	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E0E05_RS06985	COG2814	Major facilitator Superfamily
E0E05_RS06990	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
E0E05_RS07010	COG0416	fatty acid biosynthetic process
E0E05_RS07020	COG0776	regulation of translation
E0E05_RS07035	COG0110	maltose O-acetyltransferase activity
E0E05_RS07050	COG0438	transferase activity, transferring glycosyl groups
E0E05_RS07080	COG1612	heme a metabolic process
E0E05_RS07085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E0E05_RS07090	COG0010	Belongs to the arginase family
E0E05_RS07100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E0E05_RS07105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E0E05_RS07120	COG0456	acetyltransferase
E0E05_RS07120	COG0454	-acetyltransferase
E0E05_RS07125	COG1832	CoA-binding protein
E0E05_RS07155	COG2124	cytochrome p450
E0E05_RS07160	COG0740	serine-type endopeptidase activity
E0E05_RS07165	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E0E05_RS07175	COG0776	regulation of translation
E0E05_RS07190	COG2267	carboxylic ester hydrolase activity
E0E05_RS07215	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0E05_RS07220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0E05_RS07225	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0E05_RS07235	COG0649	NAD binding
E0E05_RS07240	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E0E05_RS07250	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
E0E05_RS07270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E0E05_RS07275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E0E05_RS07285	COG0713	ATP synthesis coupled electron transport
E0E05_RS07300	COG1007	ATP synthesis coupled electron transport
E0E05_RS07315	COG0346	lactoylglutathione lyase activity
E0E05_RS07325	COG0442	prolyl-tRNA aminoacylation
E0E05_RS07330	COG4591	ABC-type transport system involved in lipoprotein release permease component
E0E05_RS07335	COG1136	(ABC) transporter
E0E05_RS07345	COG0583	DNA-binding transcription factor activity
E0E05_RS07350	COG0300	oxidoreductase activity
E0E05_RS07355	COG1671	Belongs to the UPF0178 family
E0E05_RS07360	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E0E05_RS07370	COG0784	Response regulator, receiver
E0E05_RS07380	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E0E05_RS07395	COG0557	exoribonuclease II activity
E0E05_RS07400	COG1754	DNA topoisomerase type I activity
E0E05_RS07400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E0E05_RS07420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E0E05_RS07425	COG0540	Belongs to the ATCase OTCase family
E0E05_RS07430	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS07445	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
E0E05_RS07450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E0E05_RS07480	COG3811	Belongs to the UPF0386 family
E0E05_RS07500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E0E05_RS07535	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E0E05_RS07550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E0E05_RS07560	COG0511	ligase activity, forming carbon-carbon bonds
E0E05_RS07565	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E0E05_RS07575	COG0501	Belongs to the peptidase M48B family
E0E05_RS07580	COG0436	Aminotransferase
E0E05_RS07585	COG1530	ribonuclease E activity
E0E05_RS07590	COG2197	response regulator
E0E05_RS07605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E0E05_RS07610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0E05_RS07615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E0E05_RS07625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E0E05_RS07635	COG4786	Flagellar basal body rod
E0E05_RS07640	COG1157	protein secretion by the type III secretion system
E0E05_RS07650	COG1815	bacterial-type flagellum-dependent cell motility
E0E05_RS07655	COG1558	bacterial-type flagellum-dependent cell motility
E0E05_RS07660	COG1677	Flagellar hook-basal body complex protein FliE
E0E05_RS07665	COG4786	Flagellar basal body rod
E0E05_RS07670	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
E0E05_RS07675	COG1706	bacterial-type flagellum-dependent cell motility
E0E05_RS07685	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E0E05_RS07695	COG1338	Plays a role in the flagellum-specific transport system
E0E05_RS07700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0E05_RS07705	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E0E05_RS07720	COG1360	Flagellar Motor Protein
E0E05_RS07755	COG5442	Flagellar protein FlaF
E0E05_RS07760	COG5443	negative regulation of bacterial-type flagellum assembly
E0E05_RS07765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E0E05_RS07775	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E0E05_RS07780	COG1684	flagellar biosynthetic protein fliR
E0E05_RS07825	COG3408	Glycogen debranching enzyme
E0E05_RS07825	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E0E05_RS07830	COG0395	ABC-type sugar transport system, permease component
E0E05_RS07835	COG1175	transmembrane transport
E0E05_RS07850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
E0E05_RS07860	COG3609	addiction module antidote protein, CC2985 family
E0E05_RS07865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E0E05_RS07870	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0E05_RS07875	COG0628	permease
E0E05_RS07880	COG2223	nitrite transmembrane transporter activity
E0E05_RS07895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E0E05_RS07905	COG1522	sequence-specific DNA binding
E0E05_RS07910	COG0686	Belongs to the AlaDH PNT family
E0E05_RS07925	COG2897	thiosulfate sulfurtransferase activity
E0E05_RS07930	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E0E05_RS07945	COG3806	Anti-sigma factor
E0E05_RS07950	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS07955	COG2211	Major facilitator Superfamily
E0E05_RS07960	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E0E05_RS07975	COG0415	Belongs to the DNA photolyase family
E0E05_RS07980	COG0039	L-malate dehydrogenase activity
E0E05_RS08000	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E0E05_RS08015	COG0525	valine-tRNA ligase activity
E0E05_RS08030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E0E05_RS08055	COG1546	Belongs to the CinA family
E0E05_RS08055	COG1058	Belongs to the CinA family
E0E05_RS08060	COG0655	NAD(P)H dehydrogenase (quinone) activity
E0E05_RS08075	COG2885	chlorophyll binding
E0E05_RS08080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E0E05_RS08100	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
E0E05_RS08115	COG2124	cytochrome p450
E0E05_RS08140	COG0625	glutathione transferase activity
E0E05_RS08150	COG0438	transferase activity, transferring glycosyl groups
E0E05_RS08185	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0E05_RS08215	COG0081	regulation of translation
E0E05_RS08225	COG0222	ribosome binding
E0E05_RS08230	COG0085	RNA polymerase activity
E0E05_RS08235	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E0E05_RS08280	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E0E05_RS08285	COG0049	tRNA binding
E0E05_RS08290	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E0E05_RS08295	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E0E05_RS08300	COG0051	transcription antitermination factor activity, RNA binding
E0E05_RS08305	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E0E05_RS08310	COG0088	Forms part of the polypeptide exit tunnel
E0E05_RS08320	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
E0E05_RS08325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E0E05_RS08330	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
E0E05_RS08335	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E0E05_RS08340	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E0E05_RS08345	COG0255	Belongs to the universal ribosomal protein uL29 family
E0E05_RS08350	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E0E05_RS08355	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E0E05_RS08365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E0E05_RS08380	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E0E05_RS08385	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E0E05_RS08390	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E0E05_RS08395	COG1841	ribosomal large subunit assembly
E0E05_RS08400	COG0200	Binds to the 23S rRNA
E0E05_RS08405	COG0201	protein transport
E0E05_RS08410	COG0563	adenylate kinase activity
E0E05_RS08415	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
E0E05_RS08420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E0E05_RS08425	COG0202	RNA polymerase activity
E0E05_RS08430	COG0203	ribosomal protein L17
E0E05_RS08435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0E05_RS08440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E0E05_RS08455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E0E05_RS08460	COG0564	pseudouridine synthase activity
E0E05_RS08465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E0E05_RS08480	COG2723	6-phospho-beta-galactosidase activity
E0E05_RS08485	COG0174	glutamine synthetase
E0E05_RS08490	COG0347	Belongs to the P(II) protein family
E0E05_RS08495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E0E05_RS08495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E0E05_RS08500	COG0071	Belongs to the small heat shock protein (HSP20) family
E0E05_RS08505	COG0860	N-Acetylmuramoyl-L-alanine amidase
E0E05_RS08510	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
E0E05_RS08525	COG0574	Belongs to the PEP-utilizing enzyme family
E0E05_RS08525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E0E05_RS08530	COG1620	l-lactate permease
E0E05_RS08545	COG1862	Preprotein translocase
E0E05_RS08590	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
E0E05_RS08620	COG0544	peptidyl-prolyl cis-trans isomerase activity
E0E05_RS08625	COG0300	oxidoreductase activity
E0E05_RS08630	COG3046	protein related to deoxyribodipyrimidine photolyase
E0E05_RS08635	COG1760	l-serine dehydratase
E0E05_RS08650	COG0484	heat shock protein binding
E0E05_RS08655	COG1686	Belongs to the peptidase S11 family
E0E05_RS08665	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E0E05_RS08685	COG0537	adenosine 5'-monophosphoramidase activity
E0E05_RS08710	COG0052	Belongs to the universal ribosomal protein uS2 family
E0E05_RS08715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E0E05_RS08725	COG0233	cytoplasmic translational termination
E0E05_RS08730	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E0E05_RS08740	COG0750	zinc metalloprotease
E0E05_RS08750	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0E05_RS08755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E0E05_RS08770	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E0E05_RS08775	COG0372	Belongs to the citrate synthase family
E0E05_RS08790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E0E05_RS08800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E0E05_RS08815	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E0E05_RS08820	COG0343	queuine tRNA-ribosyltransferase activity
E0E05_RS08835	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E0E05_RS08840	COG0148	phosphopyruvate hydratase activity
E0E05_RS08850	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
E0E05_RS08855	COG0022	dehydrogenase e1 component
E0E05_RS08855	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0E05_RS08865	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0E05_RS08885	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E0E05_RS08900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
E0E05_RS08915	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E0E05_RS08915	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E0E05_RS08925	COG3852	Histidine kinase
E0E05_RS08930	COG2204	response regulator
E0E05_RS08935	COG5000	phosphorelay sensor kinase activity
E0E05_RS08940	COG2204	response regulator
E0E05_RS08945	COG0569	domain protein
E0E05_RS08950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0E05_RS08960	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E0E05_RS08965	COG3956	TIGRFAM MazG family protein
E0E05_RS08975	COG1234	tRNA 3'-trailer cleavage
E0E05_RS08980	COG0084	hydrolase, TatD family'
E0E05_RS08995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
E0E05_RS09000	COG1686	Belongs to the peptidase S11 family
E0E05_RS09020	COG3842	ATPase activity
E0E05_RS09025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0E05_RS09040	COG0673	inositol 2-dehydrogenase activity
E0E05_RS09045	COG0395	ABC-type sugar transport system, permease component
E0E05_RS09050	COG1175	transmembrane transport
E0E05_RS09060	COG0251	oxidation-reduction process
E0E05_RS09075	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E0E05_RS09080	COG3119	arylsulfatase activity
E0E05_RS09085	COG0395	ABC-type sugar transport system, permease component
E0E05_RS09090	COG1175	transmembrane transport
E0E05_RS09115	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0E05_RS09115	COG0473	3-isopropylmalate dehydrogenase activity
E0E05_RS09135	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS09150	COG1609	Transcriptional regulator
E0E05_RS09155	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS09170	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS09175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0E05_RS09220	COG1079	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS09225	COG4603	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS09230	COG3845	ABC transporter
E0E05_RS09235	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0E05_RS09240	COG0679	Auxin Efflux Carrier
E0E05_RS09255	COG4166	transmembrane transport
E0E05_RS09265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E0E05_RS09275	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E0E05_RS09280	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E0E05_RS09290	COG0785	Cytochrome C biogenesis protein
E0E05_RS09380	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
E0E05_RS09385	COG1086	Polysaccharide biosynthesis protein
E0E05_RS09390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E0E05_RS09410	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
E0E05_RS09415	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E0E05_RS09425	COG2089	acid synthase
E0E05_RS09440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0E05_RS09485	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E0E05_RS09495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E0E05_RS09500	COG0673	inositol 2-dehydrogenase activity
E0E05_RS09530	COG0463	Glycosyl transferase, family 2
E0E05_RS09545	COG2354	Protein conserved in bacteria
E0E05_RS09550	COG1278	Cold shock
E0E05_RS09555	COG5001	Diguanylate cyclase
E0E05_RS09555	COG3300	MHYT domain
E0E05_RS09570	COG0504	CTP synthase activity
E0E05_RS09585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0E05_RS09605	COG0303	'Molybdopterin
E0E05_RS09615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E0E05_RS09620	COG2095	MarC family integral membrane protein
E0E05_RS09635	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E0E05_RS09685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E0E05_RS09690	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
E0E05_RS09695	COG0513	Belongs to the DEAD box helicase family
E0E05_RS09705	COG3909	cytochrome
E0E05_RS09710	COG0316	Belongs to the HesB IscA family
E0E05_RS09715	COG2151	metal-sulfur cluster biosynthetic enzyme
E0E05_RS09720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E0E05_RS09725	COG0719	Fe-S assembly protein
E0E05_RS09730	COG0396	ATPase activity
E0E05_RS09750	COG0719	Fe-S assembly protein
E0E05_RS09760	COG2945	thiolester hydrolase activity
E0E05_RS09765	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E0E05_RS09775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E0E05_RS09780	COG0739	heme binding
E0E05_RS09785	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E0E05_RS09790	COG1494	fructose-1,6-bisphosphatase
E0E05_RS09800	COG0436	Aminotransferase
E0E05_RS09810	COG3243	poly(R)-hydroxyalkanoic acid synthase
E0E05_RS09815	COG1489	DNA binding
E0E05_RS09820	COG0024	Methionine aminopeptidase
E0E05_RS09825	COG2003	Belongs to the UPF0758 family
E0E05_RS09830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0E05_RS09840	COG0187	DNA topoisomerase II activity
E0E05_RS09850	COG0778	Nitroreductase
E0E05_RS09865	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E0E05_RS09890	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0E05_RS09910	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS09915	COG0019	diaminopimelate decarboxylase activity
E0E05_RS09920	COG3842	ATPase activity
E0E05_RS09930	COG1175	transmembrane transport
E0E05_RS09940	COG1414	Transcriptional regulator
E0E05_RS09955	COG1802	Transcriptional regulator
E0E05_RS09960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0E05_RS09975	COG2188	Transcriptional regulator
E0E05_RS09980	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E0E05_RS09985	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS09990	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS10010	COG0747	negative chemotaxis
E0E05_RS10015	COG0601	transmembrane transport
E0E05_RS10020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS10025	COG0444	Belongs to the ABC transporter superfamily
E0E05_RS10035	COG1473	amidohydrolase
E0E05_RS10040	COG1902	pentaerythritol trinitrate reductase activity
E0E05_RS10045	COG1414	Transcriptional regulator
E0E05_RS10055	COG4770	biotin carboxylase activity
E0E05_RS10070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E0E05_RS10070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0E05_RS10100	COG2239	Acts as a magnesium transporter
E0E05_RS10105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E0E05_RS10115	COG0302	gtp cyclohydrolase
E0E05_RS10120	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E0E05_RS10125	COG0517	IMP dehydrogenase activity
E0E05_RS10125	COG0516	GMP reductase activity
E0E05_RS10175	COG0596	Alpha beta hydrolase
E0E05_RS10185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0E05_RS10195	COG1126	abc transporter atp-binding protein
E0E05_RS10200	COG0765	amino acid transport
E0E05_RS10205	COG4597	amino acid ABC transporter
E0E05_RS10210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0E05_RS10215	COG0626	cystathionine gamma-synthase activity
E0E05_RS10220	COG1024	Enoyl-CoA hydratase
E0E05_RS10225	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS10240	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E0E05_RS10255	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS10285	COG1278	Cold shock
E0E05_RS10290	COG0346	lactoylglutathione lyase activity
E0E05_RS10330	COG3191	aminopeptidase activity
E0E05_RS10350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E0E05_RS10380	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E0E05_RS10390	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E0E05_RS10415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0E05_RS10435	COG3698	Phosphodiester glycosidase
E0E05_RS10460	COG2814	Major facilitator Superfamily
E0E05_RS10465	COG0037	tRNA processing
E0E05_RS10480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E0E05_RS10495	COG0538	isocitrate dehydrogenase activity
E0E05_RS10505	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E0E05_RS10515	COG2313	pseudouridylate synthase activity
E0E05_RS10530	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E0E05_RS10535	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
E0E05_RS10545	COG0805	protein transport
E0E05_RS10555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E0E05_RS10560	COG3842	ATPase activity
E0E05_RS10565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E0E05_RS10570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E0E05_RS10585	COG0018	arginyl-trna synthetase
E0E05_RS10590	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E0E05_RS10610	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
E0E05_RS10615	COG0129	dihydroxy-acid dehydratase activity
E0E05_RS10640	COG2062	phosphohistidine phosphatase, SixA
E0E05_RS10645	COG3106	COG3106 Predicted ATPase
E0E05_RS10650	COG3768	UPF0283 membrane protein
E0E05_RS10660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E0E05_RS10665	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
E0E05_RS10670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E0E05_RS10675	COG0633	Ferredoxin
E0E05_RS10690	COG3218	ABC-type transport auxiliary lipoprotein component
E0E05_RS10690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E0E05_RS10700	COG1127	ABC transporter
E0E05_RS10705	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E0E05_RS10710	COG4948	Mandelate Racemase Muconate Lactonizing
E0E05_RS10715	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS10720	COG0280	phosphate acetyltransferase
E0E05_RS10720	COG0281	malic enzyme
E0E05_RS10765	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E0E05_RS10785	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
E0E05_RS10790	COG0546	phosphoglycolate phosphatase activity
E0E05_RS10810	COG5001	Diguanylate cyclase
E0E05_RS10810	COG3300	MHYT domain
E0E05_RS10825	COG3842	ATPase activity
E0E05_RS10835	COG0395	ABC-type sugar transport system, permease component
E0E05_RS10840	COG1175	transmembrane transport
E0E05_RS10850	COG0673	inositol 2-dehydrogenase activity
E0E05_RS10855	COG1082	Xylose isomerase domain protein TIM barrel
E0E05_RS10865	COG1609	Transcriptional regulator
E0E05_RS10870	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
E0E05_RS10870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
E0E05_RS10885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E0E05_RS10895	COG0697	spore germination
E0E05_RS10900	COG0697	spore germination
E0E05_RS10905	COG0583	DNA-binding transcription factor activity
E0E05_RS10910	COG2814	Major facilitator Superfamily
E0E05_RS10915	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E0E05_RS10920	COG0746	molybdenum cofactor guanylyltransferase activity
E0E05_RS10930	COG0303	'Molybdopterin
E0E05_RS10940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E0E05_RS10945	COG4215	(ABC) transporter
E0E05_RS10955	COG2084	Dehydrogenase
E0E05_RS10960	COG1522	sequence-specific DNA binding
E0E05_RS10975	COG2202	Pas domain
E0E05_RS10975	COG2205	protein histidine kinase activity
E0E05_RS10980	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E0E05_RS10985	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E0E05_RS11005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E0E05_RS11010	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS11015	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0E05_RS11020	COG0509	glycine decarboxylation via glycine cleavage system
E0E05_RS11025	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0E05_RS11025	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
E0E05_RS11035	COG0583	DNA-binding transcription factor activity
E0E05_RS11050	COG3485	protocatechuate 3,4-dioxygenase
E0E05_RS11055	COG3485	protocatechuate 3,4-dioxygenase
E0E05_RS11060	COG3246	L-lysine catabolic process to acetate
E0E05_RS11070	COG1024	Enoyl-CoA hydratase
E0E05_RS11075	COG2050	protein possibly involved in aromatic compounds catabolism
E0E05_RS11085	COG1309	transcriptional regulator
E0E05_RS11090	COG2030	dehydratase
E0E05_RS11090	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS11100	COG2151	metal-sulfur cluster biosynthetic enzyme
E0E05_RS11105	COG3396	Phenylacetate-CoA oxygenase
E0E05_RS11110	COG3460	Phenylacetate-CoA oxygenase
E0E05_RS11115	COG3396	Phenylacetate-CoA oxygenase
E0E05_RS11120	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0E05_RS11120	COG1024	Enoyl-CoA hydratase
E0E05_RS11125	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
E0E05_RS11160	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS11190	COG0183	Belongs to the thiolase family
E0E05_RS11200	COG4221	oxidoreductase activity
E0E05_RS11200	COG3321	synthase
E0E05_RS11200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E0E05_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS11225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0E05_RS11230	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0E05_RS11235	COG1609	Transcriptional regulator
E0E05_RS11250	COG1230	cation diffusion facilitator family transporter
E0E05_RS11285	COG1609	Transcriptional regulator
E0E05_RS11300	COG0395	ABC-type sugar transport system, permease component
E0E05_RS11305	COG0395	ABC-type sugar transport system, permease component
E0E05_RS11315	COG3842	ATPase activity
E0E05_RS11345	COG3347	Dehydrogenase
E0E05_RS11345	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS11350	COG2390	Transcriptional regulator
E0E05_RS11355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
E0E05_RS11365	COG1129	ABC transporter
E0E05_RS11385	COG1850	ribulose-bisphosphate carboxylase activity
E0E05_RS11390	COG3958	Transketolase
E0E05_RS11395	COG3959	Transketolase, thiamine diphosphate binding domain
E0E05_RS11400	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS11415	COG0402	S-adenosylhomocysteine deaminase activity
E0E05_RS11420	COG4603	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS11425	COG4603	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS11430	COG3845	ABC transporter
E0E05_RS11445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0E05_RS11470	COG1136	(ABC) transporter
E0E05_RS11480	COG0246	Mannitol dehydrogenase
E0E05_RS11490	COG0735	belongs to the Fur family
E0E05_RS11495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E0E05_RS11500	COG1121	(ABC) transporter
E0E05_RS11510	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E0E05_RS11515	COG0673	inositol 2-dehydrogenase activity
E0E05_RS11525	COG0673	inositol 2-dehydrogenase activity
E0E05_RS11530	COG3842	ATPase activity
E0E05_RS11540	COG0395	ABC-type sugar transport system, permease component
E0E05_RS11545	COG1175	transmembrane transport
E0E05_RS11560	COG1312	Catalyzes the dehydration of D-mannonate
E0E05_RS11590	COG0493	'glutamate synthase
E0E05_RS11600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0E05_RS11605	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0E05_RS11610	COG1116	anion transmembrane transporter activity
E0E05_RS11620	COG2852	Protein conserved in bacteria
E0E05_RS11640	COG1309	transcriptional regulator
E0E05_RS11645	COG1960	acyl-CoA dehydrogenase activity
E0E05_RS11655	COG1070	Carbohydrate kinase
E0E05_RS11670	COG4214	carbohydrate transport
E0E05_RS11675	COG4213	ABC transporter substrate-binding protein
E0E05_RS11700	COG1858	cytochrome C peroxidase
E0E05_RS11710	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E0E05_RS11720	COG2351	hydroxyisourate hydrolase activity
E0E05_RS11745	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
E0E05_RS11755	COG1233	COG1233 Phytoene dehydrogenase and related
E0E05_RS11760	COG1562	ergosterol biosynthetic process
E0E05_RS11775	COG0142	geranyltranstransferase activity
E0E05_RS11780	COG0500	methyltransferase
E0E05_RS11785	COG1063	alcohol dehydrogenase
E0E05_RS11790	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
E0E05_RS11795	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E0E05_RS11800	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E0E05_RS11840	COG0156	8-amino-7-oxononanoate synthase activity
E0E05_RS11850	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
E0E05_RS11885	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
E0E05_RS11890	COG1429	ligase activity, forming nitrogen-metal bonds
E0E05_RS11900	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
E0E05_RS11920	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0E05_RS11925	COG2211	Major facilitator Superfamily
E0E05_RS11930	COG0644	oxidoreductase
E0E05_RS11940	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
E0E05_RS11945	COG1522	sequence-specific DNA binding
E0E05_RS11955	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS11970	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E0E05_RS11995	COG2010	Cytochrome c
E0E05_RS12020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0E05_RS12035	COG0601	transmembrane transport
E0E05_RS12040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS12045	COG0444	Belongs to the ABC transporter superfamily
E0E05_RS12050	COG4608	Belongs to the ABC transporter superfamily
E0E05_RS12060	COG0523	cobalamin synthesis protein
E0E05_RS12065	COG2249	NAD(P)H dehydrogenase (quinone) activity
E0E05_RS12070	COG2249	NAD(P)H dehydrogenase (quinone) activity
E0E05_RS12080	COG0402	S-adenosylhomocysteine deaminase activity
E0E05_RS12085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0E05_RS12100	COG0251	oxidation-reduction process
E0E05_RS12110	COG0831	urea catabolic process
E0E05_RS12120	COG0832	Belongs to the urease beta subunit family
E0E05_RS12125	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
E0E05_RS12150	COG0804	urea catabolic process
E0E05_RS12165	COG1376	ErfK ybiS ycfS ynhG family protein
E0E05_RS12180	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
E0E05_RS12195	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
E0E05_RS12200	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E0E05_RS12205	COG1116	anion transmembrane transporter activity
E0E05_RS12210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E0E05_RS12235	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E0E05_RS12245	COG1959	2 iron, 2 sulfur cluster binding
E0E05_RS12250	COG1840	ABC-type Fe3 transport system, periplasmic component
E0E05_RS12255	COG1178	ABC-type Fe3 transport system permease component
E0E05_RS12280	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E0E05_RS12290	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E0E05_RS12305	COG2176	DNA-directed DNA polymerase activity
E0E05_RS12305	COG5002	protein histidine kinase activity
E0E05_RS12310	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E0E05_RS12310	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
E0E05_RS12315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS12320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0E05_RS12330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E0E05_RS12350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E0E05_RS12360	COG0747	negative chemotaxis
E0E05_RS12380	COG0601	transmembrane transport
E0E05_RS12385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS12395	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E0E05_RS12405	COG1797	cobyrinic acid a,c-diamide synthase activity
E0E05_RS12415	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E0E05_RS12420	COG2099	Precorrin-6x reductase
E0E05_RS12450	COG2875	Belongs to the precorrin methyltransferase family
E0E05_RS12540	COG1492	cobalamin metabolic process
E0E05_RS12575	COG5598	trimethylamine methyltransferase
E0E05_RS12580	COG5012	cobalamin binding
E0E05_RS12590	COG0463	Glycosyl transferase, family 2
E0E05_RS12600	COG3932	Exopolysaccharide synthesis, ExoD
E0E05_RS12605	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E0E05_RS12615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E0E05_RS12620	COG1410	methionine synthase
E0E05_RS12620	COG0646	methionine synthase
E0E05_RS12625	COG2827	Endonuclease containing a URI domain
E0E05_RS12645	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
E0E05_RS12725	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
E0E05_RS12735	COG3264	Mechanosensitive ion channel
E0E05_RS12735	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
E0E05_RS12740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0E05_RS12750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0E05_RS12750	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0E05_RS12765	COG0366	Alpha amylase catalytic
E0E05_RS12770	COG0402	S-adenosylhomocysteine deaminase activity
E0E05_RS12845	COG2358	TRAP transporter, solute receptor (TAXI family
E0E05_RS12855	COG0589	response to stress
E0E05_RS12860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0E05_RS12880	COG0693	protein deglycase activity
E0E05_RS12885	COG0384	phenazine biosynthesis protein PhzF
E0E05_RS12910	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0E05_RS12910	COG0475	glutathione-regulated potassium exporter activity
E0E05_RS12920	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E0E05_RS12945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E0E05_RS12955	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0E05_RS12980	COG0028	Belongs to the TPP enzyme family
E0E05_RS13000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
E0E05_RS13005	COG0560	Phosphoserine phosphatase
E0E05_RS13005	COG3830	Belongs to the UPF0237 family
E0E05_RS13010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E0E05_RS13020	COG0330	HflC and HflK could
E0E05_RS13045	COG3093	addiction module antidote protein HigA
E0E05_RS13070	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E0E05_RS13100	COG0277	FAD linked oxidase domain protein
E0E05_RS13115	COG0038	chloride channel
E0E05_RS13120	COG0210	DNA helicase
E0E05_RS13160	COG1999	signal sequence binding
E0E05_RS13170	COG2264	protein methyltransferase activity
E0E05_RS13210	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E0E05_RS13215	COG0497	DNA recombination
E0E05_RS13220	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E0E05_RS13230	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E0E05_RS13235	COG0849	cell division
E0E05_RS13240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E0E05_RS13245	COG1181	Belongs to the D-alanine--D-alanine ligase family
E0E05_RS13250	COG0534	Mate efflux family protein
E0E05_RS13265	COG0305	Participates in initiation and elongation during chromosome replication
E0E05_RS13285	COG0006	proline dipeptidase activity
E0E05_RS13305	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E0E05_RS13310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E0E05_RS13315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E0E05_RS13335	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E0E05_RS13340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E0E05_RS13345	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E0E05_RS13350	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E0E05_RS13365	COG0275	rRNA processing
E0E05_RS13380	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E0E05_RS13385	COG0424	maF-like protein
E0E05_RS13390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E0E05_RS13395	COG2226	methyltransferase
E0E05_RS13400	COG5328	Belongs to the UPF0262 family
E0E05_RS13405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E0E05_RS13435	COG0668	transmembrane transport
E0E05_RS13440	COG3769	mannosylglycerate metabolic process
E0E05_RS13445	COG1215	transferase activity, transferring glycosyl groups
E0E05_RS13480	COG0436	Aminotransferase
E0E05_RS13485	COG3287	FIST C domain
E0E05_RS13485	COG2200	EAL domain
E0E05_RS13485	COG2199	diguanylate cyclase activity
E0E05_RS13490	COG0625	glutathione transferase activity
E0E05_RS13500	COG2133	pyrroloquinoline quinone binding
E0E05_RS13540	COG4948	Mandelate Racemase Muconate Lactonizing
E0E05_RS13550	COG2200	EAL domain
E0E05_RS13575	COG2738	Putative neutral zinc metallopeptidase
E0E05_RS13585	COG0583	DNA-binding transcription factor activity
E0E05_RS13590	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0E05_RS13605	COG0671	phosphoesterase, PA-phosphatase related
E0E05_RS13630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
E0E05_RS13650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E0E05_RS13655	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
E0E05_RS13660	COG1846	Transcriptional regulator
E0E05_RS13665	COG0745	RESPONSE REGULATOR receiver
E0E05_RS13670	COG2205	protein histidine kinase activity
E0E05_RS13675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E0E05_RS13690	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
E0E05_RS13715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E0E05_RS13720	COG3794	PFAM blue (type 1) copper domain protein
E0E05_RS13730	COG3657	addiction module killer protein
E0E05_RS13735	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E0E05_RS13740	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS13745	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
E0E05_RS13750	COG0193	aminoacyl-tRNA hydrolase activity
E0E05_RS13770	COG0012	GTP binding
E0E05_RS13790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
E0E05_RS13800	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E0E05_RS13800	COG2857	Cytochrome c1
E0E05_RS13810	COG0723	plastoquinol--plastocyanin reductase activity
E0E05_RS13815	COG1132	(ABC) transporter
E0E05_RS13825	COG1598	PFAM Uncharacterised protein family UPF0150
E0E05_RS13830	COG1132	(ABC) transporter
E0E05_RS13840	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E0E05_RS13855	COG0408	coproporphyrinogen oxidase activity
E0E05_RS13890	COG0714	Associated with various cellular activities
E0E05_RS13915	COG0435	Glutathione S-transferase
E0E05_RS13920	COG0494	nUDIX hydrolase
E0E05_RS13940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E0E05_RS13950	COG0512	Glutamine amidotransferase of anthranilate synthase
E0E05_RS13950	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E0E05_RS13955	COG2759	Belongs to the formate--tetrahydrofolate ligase family
E0E05_RS14000	COG1435	thymidine kinase activity
E0E05_RS14035	COG2201	protein-glutamate methylesterase activity
E0E05_RS14065	COG0482	sulfurtransferase activity
E0E05_RS14090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0E05_RS14120	COG3608	succinylglutamate desuccinylase aspartoacylase
E0E05_RS14125	COG0006	proline dipeptidase activity
E0E05_RS14130	COG2423	ornithine cyclodeaminase activity
E0E05_RS14135	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E0E05_RS14145	COG0589	response to stress
E0E05_RS14150	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0E05_RS14155	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0E05_RS14160	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0E05_RS14165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E0E05_RS14170	COG1522	sequence-specific DNA binding
E0E05_RS14175	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS14180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E0E05_RS14185	COG0410	ABC transporter
E0E05_RS14210	COG1396	sequence-specific DNA binding
E0E05_RS14210	COG3800	Transcriptional regulator
E0E05_RS14215	COG0745	RESPONSE REGULATOR receiver
E0E05_RS14225	COG5002	protein histidine kinase activity
E0E05_RS14230	COG1177	transmembrane transport
E0E05_RS14245	COG3842	ATPase activity
E0E05_RS14255	COG0564	pseudouridine synthase activity
E0E05_RS14260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E0E05_RS14270	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E0E05_RS14285	COG3657	addiction module killer protein
E0E05_RS14290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E0E05_RS14295	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E0E05_RS14305	COG4977	sequence-specific DNA binding
E0E05_RS14320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E0E05_RS14335	COG3321	synthase
E0E05_RS14335	COG0604	alcohol dehydrogenase
E0E05_RS14335	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS14345	COG2378	regulation of single-species biofilm formation
E0E05_RS14380	COG3588	fructose-bisphosphate aldolase
E0E05_RS14385	COG0126	phosphoglycerate kinase activity
E0E05_RS14390	COG0251	oxidation-reduction process
E0E05_RS14415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
E0E05_RS14425	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E0E05_RS14430	COG1692	metallophosphoesterase
E0E05_RS14470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
E0E05_RS14485	COG0632	four-way junction helicase activity
E0E05_RS14500	COG2255	four-way junction helicase activity
E0E05_RS14525	COG0824	Thioesterase
E0E05_RS14530	COG0811	peptide transport
E0E05_RS14535	COG0848	biopolymer transport protein
E0E05_RS14545	COG0823	Involved in the tonB-independent uptake of proteins
E0E05_RS14550	COG2885	chlorophyll binding
E0E05_RS14560	COG0037	tRNA processing
E0E05_RS14565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E0E05_RS14570	COG0254	rRNA binding
E0E05_RS14575	COG1132	(ABC) transporter
E0E05_RS14595	COG0483	inositol monophosphate 1-phosphatase activity
E0E05_RS14600	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E0E05_RS14615	COG0640	Transcriptional regulator
E0E05_RS14630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E0E05_RS14635	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E0E05_RS14640	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E0E05_RS14645	COG0457	Tetratricopeptide repeat
E0E05_RS14650	COG2267	carboxylic ester hydrolase activity
E0E05_RS14655	COG0469	pyruvate kinase activity
E0E05_RS14675	COG2951	lytic endotransglycosylase activity
E0E05_RS14690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E0E05_RS14695	COG0737	Belongs to the 5'-nucleotidase family
E0E05_RS14725	COG3750	Belongs to the UPF0335 family
E0E05_RS14755	COG0067	glutamate synthase
E0E05_RS14755	COG0069	glutamate synthase activity
E0E05_RS14755	COG0070	glutamate synthase
E0E05_RS14770	COG3220	belongs to the UPF0276 family
E0E05_RS14785	COG0071	Belongs to the small heat shock protein (HSP20) family
E0E05_RS14845	COG0446	pyridine nucleotide-disulphide oxidoreductase
E0E05_RS14845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E0E05_RS14860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E0E05_RS14865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E0E05_RS14905	COG5001	Diguanylate cyclase
E0E05_RS14910	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS14920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
E0E05_RS14920	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0E05_RS14925	COG0318	PFAM AMP-dependent synthetase and ligase
E0E05_RS14950	COG0436	Aminotransferase
E0E05_RS14960	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS14970	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
E0E05_RS14980	COG0583	DNA-binding transcription factor activity
E0E05_RS14985	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
E0E05_RS15000	COG1846	Transcriptional regulator
E0E05_RS15005	COG1609	Transcriptional regulator
E0E05_RS15010	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E0E05_RS15020	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E0E05_RS15025	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0E05_RS15030	COG0800	Aldolase
E0E05_RS15040	COG1054	Belongs to the UPF0176 family
E0E05_RS15045	COG3844	kynureninase activity
E0E05_RS15050	COG0829	nickel cation binding
E0E05_RS15055	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E0E05_RS15060	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E0E05_RS15070	COG4651	solute:proton antiporter activity
E0E05_RS15070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E0E05_RS15075	COG0589	response to stress
E0E05_RS15080	COG2855	membrane
E0E05_RS15090	COG0367	asparagine synthase
E0E05_RS15095	COG0189	ligase activity
E0E05_RS15095	COG2918	glutathione biosynthetic process
E0E05_RS15100	COG1363	Peptidase, m42
E0E05_RS15110	COG0747	negative chemotaxis
E0E05_RS15120	COG0444	Belongs to the ABC transporter superfamily
E0E05_RS15125	COG4608	Belongs to the ABC transporter superfamily
E0E05_RS15130	COG2186	Transcriptional regulator
E0E05_RS15140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
E0E05_RS15145	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E0E05_RS15155	COG0539	negative regulation of cytoplasmic translation
E0E05_RS15160	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
E0E05_RS15180	COG0028	Belongs to the TPP enzyme family
E0E05_RS15185	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E0E05_RS15190	COG3454	Phosphonate metabolism
E0E05_RS15195	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS15205	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E0E05_RS15210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E0E05_RS15215	COG0443	Heat shock 70 kDa protein
E0E05_RS15235	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E0E05_RS15240	COG0662	Cupin 2, conserved barrel domain protein
E0E05_RS15240	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
E0E05_RS15250	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS15265	COG0601	transmembrane transport
E0E05_RS15270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E0E05_RS15285	COG0747	negative chemotaxis
E0E05_RS15315	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS15345	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E0E05_RS15380	COG0506	proline dehydrogenase activity
E0E05_RS15395	COG0402	S-adenosylhomocysteine deaminase activity
E0E05_RS15405	COG3845	ABC transporter
E0E05_RS15410	COG4603	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS15415	COG1079	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS15455	COG0531	amino acid
E0E05_RS15470	COG2217	Heavy metal translocating P-type atpase
E0E05_RS15535	COG0739	heme binding
E0E05_RS15540	COG0477	Major facilitator Superfamily
E0E05_RS15555	COG2086	electron transfer activity
E0E05_RS15580	COG0300	oxidoreductase activity
E0E05_RS15595	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E0E05_RS15615	COG3932	Exopolysaccharide synthesis, ExoD
E0E05_RS15625	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS15640	COG0653	protein targeting
E0E05_RS15645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E0E05_RS15650	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E0E05_RS15660	COG0494	nUDIX hydrolase
E0E05_RS15675	COG2226	methyltransferase
E0E05_RS15680	COG1040	competence protein
E0E05_RS15690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E0E05_RS15700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
E0E05_RS15705	COG0527	aspartate kinase activity
E0E05_RS15715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E0E05_RS15720	COG2890	protein-(glutamine-N5) methyltransferase activity
E0E05_RS15735	COG0542	response to heat
E0E05_RS15745	COG1250	3-hydroxyacyl-CoA dehydrogenase
E0E05_RS15755	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E0E05_RS15785	COG1476	TRANSCRIPTIONal
E0E05_RS15795	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E0E05_RS15810	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0E05_RS15825	COG2376	Dihydroxyacetone kinase
E0E05_RS15840	COG1012	belongs to the aldehyde dehydrogenase family
E0E05_RS15860	COG0641	radical SAM
E0E05_RS15870	COG1129	ABC transporter
E0E05_RS15875	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS15880	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS15885	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS15890	COG1879	ABC-type sugar transport system periplasmic component
E0E05_RS15905	COG0006	proline dipeptidase activity
E0E05_RS15910	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS15915	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS15930	COG2132	Multicopper oxidase
E0E05_RS15935	COG3794	PFAM blue (type 1) copper domain protein
E0E05_RS15960	COG1959	2 iron, 2 sulfur cluster binding
E0E05_RS15990	COG4948	Mandelate Racemase Muconate Lactonizing
E0E05_RS16025	COG1309	transcriptional regulator
E0E05_RS16040	COG4175	Glycine betaine
E0E05_RS16050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
E0E05_RS16060	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
E0E05_RS16065	COG0673	inositol 2-dehydrogenase activity
E0E05_RS16070	COG1028	Short-chain dehydrogenase reductase Sdr
E0E05_RS16075	COG2204	response regulator
E0E05_RS16075	COG5564	TIM-barrel signal transduction protein
E0E05_RS16090	COG5564	TIM-barrel signal transduction protein
E0E05_RS16110	COG1312	Catalyzes the dehydration of D-mannonate
E0E05_RS16115	COG1312	Catalyzes the dehydration of D-mannonate
E0E05_RS16120	COG2186	Transcriptional regulator
E0E05_RS16125	COG1879	ABC-type sugar transport system periplasmic component
E0E05_RS16130	COG1129	ABC transporter
E0E05_RS16135	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS16145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E0E05_RS16160	COG3842	ATPase activity
E0E05_RS16165	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
E0E05_RS16185	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E0E05_RS16200	COG1228	amidohydrolase
E0E05_RS16210	COG1737	Transcriptional regulator
E0E05_RS16210	COG0837	glucose binding
E0E05_RS16220	COG3608	succinylglutamate desuccinylase aspartoacylase
E0E05_RS16230	COG1175	transmembrane transport
E0E05_RS16235	COG0395	ABC-type sugar transport system, permease component
E0E05_RS16250	COG4948	Mandelate Racemase Muconate Lactonizing
E0E05_RS16255	COG3842	ATPase activity
E0E05_RS16265	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E0E05_RS16270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E0E05_RS16275	COG1869	D-ribose catabolic process
E0E05_RS16280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E0E05_RS16295	COG1172	Belongs to the binding-protein-dependent transport system permease family
E0E05_RS16300	COG5285	phytanoyl-CoA dioxygenase
E0E05_RS16315	COG0583	DNA-binding transcription factor activity
E0E05_RS16325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E0E05_RS16360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E0E05_RS16365	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0E05_RS16370	COG0508	dehydrogenase complex catalyzes the overall conversion of
E0E05_RS16370	COG0022	dehydrogenase e1 component
E0E05_RS16375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS16380	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0E05_RS16385	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0E05_RS16405	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E0E05_RS16415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E0E05_RS16450	COG3743	rRNA binding
E0E05_RS16450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E0E05_RS16455	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E0E05_RS16470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E0E05_RS16475	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
E0E05_RS16480	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E0E05_RS16485	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
E0E05_RS16490	COG0799	negative regulation of ribosome biogenesis
E0E05_RS16495	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E0E05_RS16510	COG0793	Belongs to the peptidase S41A family
E0E05_RS16520	COG0494	nUDIX hydrolase
E0E05_RS16530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E0E05_RS16540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E0E05_RS16545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E0E05_RS16550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E0E05_RS16555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E0E05_RS16565	COG0697	spore germination
E0E05_RS16575	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
E0E05_RS16620	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
E0E05_RS16635	COG1595	DNA-templated transcription, initiation
E0E05_RS16645	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E0E05_RS16660	COG4974	Belongs to the 'phage' integrase family
E0E05_RS16665	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E0E05_RS16670	COG0336	Belongs to the RNA methyltransferase TrmD family
E0E05_RS16675	COG0335	large ribosomal subunit rRNA binding
E0E05_RS16690	COG0765	amino acid transport
E0E05_RS16695	COG1032	radical SAM domain protein
E0E05_RS16700	COG1719	4-vinyl reductase, 4VR
E0E05_RS16705	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E0E05_RS16720	COG3339	Conserved Protein
E0E05_RS16730	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E0E05_RS16735	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
E0E05_RS16745	COG4181	ATPase activity
E0E05_RS16750	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
E0E05_RS16755	COG0670	Belongs to the BI1 family
E0E05_RS16805	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E0E05_RS16810	COG4133	protoheme IX ABC transporter activity
E0E05_RS16815	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0E05_RS16835	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E0E05_RS16845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E0E05_RS16850	COG2814	Major facilitator Superfamily
E0E05_RS16865	COG4176	ABC-type proline glycine betaine transport system permease component
E0E05_RS16870	COG0517	IMP dehydrogenase activity
E0E05_RS16870	COG4175	Glycine betaine
E0E05_RS16875	COG0667	Aldo Keto reductase
E0E05_RS16880	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E0E05_RS16900	COG1217	gtp-binding protein TYPA
E0E05_RS16930	COG0181	hydroxymethylbilane synthase activity
E0E05_RS16935	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E0E05_RS16940	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
E0E05_RS16955	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E0E05_RS16965	COG0583	DNA-binding transcription factor activity
E0E05_RS16970	COG2223	nitrite transmembrane transporter activity
E0E05_RS16975	COG3618	amidohydrolase
E0E05_RS16980	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
E0E05_RS17030	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
E0E05_RS17035	COG3257	ureidoglycine aminohydrolase activity
E0E05_RS17055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E0E05_RS17060	COG1946	Acyl-CoA thioesterase
E0E05_RS17065	COG0347	Belongs to the P(II) protein family
E0E05_RS17070	COG0004	ammonium transporteR
E0E05_RS17075	COG2261	transglycosylase associated protein
E0E05_RS17075	COG1674	ftsk spoiiie
E0E05_RS17080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E0E05_RS17095	COG0745	RESPONSE REGULATOR receiver
E0E05_RS17120	COG0501	Belongs to the peptidase M48B family
E0E05_RS17135	COG0138	bifunctional purine biosynthesis protein purh
E0E05_RS17145	COG0425	Belongs to the sulfur carrier protein TusA family
E0E05_RS17145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E0E05_RS17150	COG1686	Belongs to the peptidase S11 family
E0E05_RS17155	COG1473	amidohydrolase
E0E05_RS17160	COG0640	Transcriptional regulator
E0E05_RS17225	COG0671	phosphoesterase, PA-phosphatase related
E0E05_RS17235	COG3842	ATPase activity
E0E05_RS17255	COG3639	organic phosphonate transmembrane transporter activity
E0E05_RS17260	COG3639	organic phosphonate transmembrane transporter activity
E0E05_RS17265	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E0E05_RS17280	COG4778	phosphonate C-P lyase system protein PhnL
E0E05_RS17285	COG4107	phosphonate C-P lyase system protein PhnK
E0E05_RS17290	COG3627	carbon phosphorus lyase activity
E0E05_RS17300	COG3624	Phosphonate C-P lyase system protein PhnG