locus-tag	class	description
RD1_RS00010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS00045	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS00045	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS00050	COG4311	Sarcosine oxidase, delta subunit
RD1_RS00055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS00065	COG0517	IMP dehydrogenase activity
RD1_RS00065	COG4175	Glycine betaine
RD1_RS00075	COG0564	pseudouridine synthase activity
RD1_RS00105	COG1956	GAF domain-containing protein
RD1_RS00110	COG0183	Belongs to the thiolase family
RD1_RS00125	COG0405	Gamma-glutamyltransferase
RD1_RS00150	COG1674	ftsk spoiiie
RD1_RS00155	COG0436	Aminotransferase
RD1_RS00160	COG0154	amidase activity
RD1_RS00165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD1_RS00170	COG2835	tetraacyldisaccharide 4'-kinase activity
RD1_RS00175	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD1_RS00185	COG0708	Exodeoxyribonuclease III
RD1_RS00190	COG0745	RESPONSE REGULATOR receiver
RD1_RS00220	COG0495	leucyl-tRNA aminoacylation
RD1_RS00235	COG0625	glutathione transferase activity
RD1_RS00245	COG3264	Mechanosensitive ion channel
RD1_RS00245	COG1196	nuclear chromosome segregation
RD1_RS00255	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RD1_RS00265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
RD1_RS00290	COG1968	undecaprenyl-diphosphatase activity
RD1_RS00320	COG1556	Lactate utilization protein
RD1_RS00325	COG1139	Iron-sulfur cluster binding protein
RD1_RS00330	COG0247	lactate metabolic process
RD1_RS00335	COG0277	FAD linked oxidase domain protein
RD1_RS00345	COG2995	paraquat-inducible protein a
RD1_RS00350	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RD1_RS00350	COG3008	intermembrane lipid transfer
RD1_RS00375	COG0069	glutamate synthase activity
RD1_RS00390	COG0784	Response regulator, receiver
RD1_RS00395	COG1295	ribonuclease BN
RD1_RS00405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD1_RS00410	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
RD1_RS00415	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
RD1_RS00445	COG0662	Cupin 2, conserved barrel domain protein
RD1_RS00450	COG3191	aminopeptidase activity
RD1_RS00455	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD1_RS00490	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RD1_RS00495	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RD1_RS00500	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RD1_RS00505	COG1063	alcohol dehydrogenase
RD1_RS00510	COG0500	methyltransferase
RD1_RS00515	COG0142	geranyltranstransferase activity
RD1_RS00520	COG1233	COG1233 Phytoene dehydrogenase and related
RD1_RS00525	COG5621	secreted hydrolase
RD1_RS00535	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
RD1_RS00540	COG1562	ergosterol biosynthetic process
RD1_RS00545	COG1233	COG1233 Phytoene dehydrogenase and related
RD1_RS00555	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RD1_RS00560	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
RD1_RS00575	COG3474	cytochrome
RD1_RS00580	COG0156	8-amino-7-oxononanoate synthase activity
RD1_RS00590	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
RD1_RS00625	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
RD1_RS00630	COG1429	ligase activity, forming nitrogen-metal bonds
RD1_RS00635	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RD1_RS00640	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
RD1_RS00660	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RD1_RS00665	COG2211	Major facilitator Superfamily
RD1_RS00670	COG0644	oxidoreductase
RD1_RS00675	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
RD1_RS00685	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD1_RS00695	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RD1_RS00725	COG2801	Transposase and inactivated derivatives
RD1_RS00735	COG5443	negative regulation of bacterial-type flagellum assembly
RD1_RS00770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS00775	COG1177	transmembrane transport
RD1_RS00780	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS00785	COG3842	ATPase activity
RD1_RS00805	COG3842	ATPase activity
RD1_RS00825	COG1177	transmembrane transport
RD1_RS00830	COG2951	lytic endotransglycosylase activity
RD1_RS00840	COG0557	exoribonuclease II activity
RD1_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD1_RS00865	COG2171	N-acyltransferase activity
RD1_RS00880	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RD1_RS00895	COG0560	Phosphoserine phosphatase
RD1_RS00900	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RD1_RS00905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD1_RS00910	COG1063	alcohol dehydrogenase
RD1_RS00915	COG0156	8-amino-7-oxononanoate synthase activity
RD1_RS00920	COG1396	sequence-specific DNA binding
RD1_RS00925	COG0183	Belongs to the thiolase family
RD1_RS00935	COG2226	methyltransferase
RD1_RS00940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
RD1_RS00945	COG1024	Enoyl-CoA hydratase
RD1_RS00955	COG0268	Binds directly to 16S ribosomal RNA
RD1_RS00960	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RD1_RS00970	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
RD1_RS01000	COG1573	uracil-dna glycosylase
RD1_RS01005	COG0673	inositol 2-dehydrogenase activity
RD1_RS01010	COG0191	fructose-bisphosphate aldolase activity
RD1_RS01020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS01025	COG3962	Belongs to the TPP enzyme family
RD1_RS01030	COG0673	inositol 2-dehydrogenase activity
RD1_RS01035	COG1082	Xylose isomerase domain protein TIM barrel
RD1_RS01040	COG0673	inositol 2-dehydrogenase activity
RD1_RS01050	COG0066	3-isopropylmalate dehydratase activity
RD1_RS01060	COG0473	3-isopropylmalate dehydrogenase activity
RD1_RS01065	COG0697	spore germination
RD1_RS01070	COG0747	negative chemotaxis
RD1_RS01085	COG1609	Transcriptional regulator
RD1_RS01090	COG3214	Protein conserved in bacteria
RD1_RS01110	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD1_RS01120	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD1_RS01120	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS01140	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
RD1_RS01180	COG1558	bacterial-type flagellum-dependent cell motility
RD1_RS01185	COG1677	Flagellar hook-basal body complex protein FliE
RD1_RS01190	COG1987	bacterial-type flagellum assembly
RD1_RS01195	COG4786	Flagellar basal body rod
RD1_RS01200	COG4786	Flagellar basal body rod
RD1_RS01210	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
RD1_RS01230	COG2801	Transposase and inactivated derivatives
RD1_RS01235	COG1338	Plays a role in the flagellum-specific transport system
RD1_RS01240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD1_RS01270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RD1_RS01285	COG3842	ATPase activity
RD1_RS01290	COG1177	transmembrane transport
RD1_RS01320	COG2072	flavoprotein involved in K transport
RD1_RS01350	COG0312	modulator of DNA gyrase
RD1_RS01365	COG1519	Transferase
RD1_RS01370	COG1663	tetraacyldisaccharide 4'-kinase activity
RD1_RS01385	COG1194	a g-specific adenine glycosylase
RD1_RS01395	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
RD1_RS01425	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RD1_RS01435	COG0584	glycerophosphoryl diester phosphodiesterase
RD1_RS01455	COG0288	reversible hydration of carbon dioxide
RD1_RS01465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD1_RS01490	COG0679	Auxin Efflux Carrier
RD1_RS01495	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD1_RS01500	COG1671	Belongs to the UPF0178 family
RD1_RS01510	COG2423	ornithine cyclodeaminase activity
RD1_RS01525	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
RD1_RS01530	COG0285	dihydrofolate synthase activity
RD1_RS01535	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RD1_RS01550	COG0129	dihydroxy-acid dehydratase activity
RD1_RS01555	COG0793	Belongs to the peptidase S41A family
RD1_RS01565	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
RD1_RS01570	COG0587	DNA-directed DNA polymerase activity
RD1_RS01610	COG4397	Mu-like prophage major head subunit gpT
RD1_RS01635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RD1_RS01635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
RD1_RS01640	COG3622	Belongs to the hyi family
RD1_RS01650	COG0714	Associated with various cellular activities
RD1_RS01670	COG5002	protein histidine kinase activity
RD1_RS01670	COG0784	Response regulator, receiver
RD1_RS01670	COG2205	protein histidine kinase activity
RD1_RS01675	COG3022	response to hydroperoxide
RD1_RS01680	COG0514	ATP-dependent DNA helicase (RecQ)
RD1_RS01690	COG2270	Major facilitator Superfamily
RD1_RS01695	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
RD1_RS01705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
RD1_RS01715	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RD1_RS01720	COG0517	IMP dehydrogenase activity
RD1_RS01720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RD1_RS01735	COG1137	ATPase activity
RD1_RS01740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
RD1_RS01745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
RD1_RS01750	COG1210	Utp--glucose-1-phosphate uridylyltransferase
RD1_RS01755	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RD1_RS01760	COG1218	3'(2'),5'-bisphosphate nucleotidase
RD1_RS01770	COG0443	Heat shock 70 kDa protein
RD1_RS01775	COG0484	heat shock protein binding
RD1_RS01780	COG0653	protein targeting
RD1_RS01785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RD1_RS01790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
RD1_RS01795	COG0494	nUDIX hydrolase
RD1_RS01800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
RD1_RS01815	COG0779	Required for maturation of 30S ribosomal subunits
RD1_RS01830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD1_RS01840	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RD1_RS01855	COG2226	methyltransferase
RD1_RS01880	COG3034	peptidoglycan biosynthetic process
RD1_RS01895	COG1132	(ABC) transporter
RD1_RS01900	COG1132	(ABC) transporter
RD1_RS01910	COG0494	nUDIX hydrolase
RD1_RS01925	COG2205	protein histidine kinase activity
RD1_RS01925	COG0745	RESPONSE REGULATOR receiver
RD1_RS01925	COG3292	Two component regulator propeller
RD1_RS01940	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD1_RS01945	COG0137	argininosuccinate synthase activity
RD1_RS01955	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RD1_RS01960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS01965	COG0280	phosphate acetyltransferase
RD1_RS01965	COG0281	malic enzyme
RD1_RS01970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
RD1_RS01975	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
RD1_RS01985	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
RD1_RS01990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
RD1_RS01995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD1_RS02010	COG0357	Ribosomal RNA small subunit methyltransferase G
RD1_RS02015	COG0445	tRNA wobble uridine modification
RD1_RS02020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
RD1_RS02025	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RD1_RS02030	COG1981	membrane
RD1_RS02035	COG0424	maF-like protein
RD1_RS02040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RD1_RS02045	COG0237	dephospho-CoA kinase activity
RD1_RS02050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
RD1_RS02055	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
RD1_RS02060	COG3030	protein affecting phage T7 exclusion by the F plasmid
RD1_RS02080	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RD1_RS02090	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
RD1_RS02100	COG1074	ATP-dependent DNA helicase activity
RD1_RS02110	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
RD1_RS02115	COG3178	'Phosphotransferase
RD1_RS02120	COG0802	atpase or kinase
RD1_RS02135	COG1999	signal sequence binding
RD1_RS02140	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
RD1_RS02145	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
RD1_RS02155	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
RD1_RS02170	COG2350	Protein conserved in bacteria
RD1_RS02175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RD1_RS02180	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RD1_RS02210	COG1024	Enoyl-CoA hydratase
RD1_RS02235	COG5642	Protein of unknown function (DUF2384)
RD1_RS02245	COG3718	enzyme involved in inositol metabolism
RD1_RS02255	COG1172	Belongs to the binding-protein-dependent transport system permease family
RD1_RS02265	COG1609	Transcriptional regulator
RD1_RS02295	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RD1_RS02335	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS02340	COG1960	acyl-CoA dehydrogenase activity
RD1_RS02360	COG1024	Enoyl-CoA hydratase
RD1_RS02385	COG1063	alcohol dehydrogenase
RD1_RS02390	COG1309	transcriptional regulator
RD1_RS02400	COG0395	ABC-type sugar transport system, permease component
RD1_RS02405	COG1175	transmembrane transport
RD1_RS02410	COG1653	transport
RD1_RS02445	COG0714	Associated with various cellular activities
RD1_RS02455	COG3119	arylsulfatase activity
RD1_RS02515	COG1122	ATPase activity
RD1_RS02525	COG0346	lactoylglutathione lyase activity
RD1_RS02530	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS02540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RD1_RS02545	COG0142	geranyltranstransferase activity
RD1_RS02550	COG1722	exodeoxyribonuclease VII activity
RD1_RS02555	COG0745	RESPONSE REGULATOR receiver
RD1_RS02560	COG1846	Transcriptional regulator
RD1_RS02565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
RD1_RS02580	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
RD1_RS02585	COG4143	(ABC) transporter
RD1_RS02590	COG1178	ABC-type Fe3 transport system permease component
RD1_RS02595	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
RD1_RS02605	COG2808	Putative FMN-binding domain
RD1_RS02630	COG2814	Major facilitator Superfamily
RD1_RS02640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD1_RS02675	COG1706	bacterial-type flagellum-dependent cell motility
RD1_RS02700	COG1054	Belongs to the UPF0176 family
RD1_RS02705	COG1335	isochorismatase
RD1_RS02710	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
RD1_RS02725	COG1132	(ABC) transporter
RD1_RS02750	COG0386	Belongs to the glutathione peroxidase family
RD1_RS02770	COG0776	regulation of translation
RD1_RS02775	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RD1_RS02780	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
RD1_RS02795	COG0235	Class ii aldolase
RD1_RS02795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RD1_RS02805	COG1960	acyl-CoA dehydrogenase activity
RD1_RS02815	COG1024	Enoyl-CoA hydratase
RD1_RS02830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RD1_RS02835	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RD1_RS02835	COG3264	Mechanosensitive ion channel
RD1_RS02845	COG0799	negative regulation of ribosome biogenesis
RD1_RS02850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
RD1_RS02870	COG0277	FAD linked oxidase domain protein
RD1_RS02875	COG0277	FAD linked oxidase domain protein
RD1_RS02880	COG0247	lactate metabolic process
RD1_RS02885	COG3591	Belongs to the peptidase S1B family
RD1_RS02890	COG0071	Belongs to the small heat shock protein (HSP20) family
RD1_RS02915	COG0450	alkyl hydroperoxide reductase
RD1_RS02930	COG1185	polyribonucleotide nucleotidyltransferase activity
RD1_RS02935	COG1115	amino acid carrier protein
RD1_RS02950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RD1_RS02975	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
RD1_RS02985	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
RD1_RS02990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
RD1_RS03005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
RD1_RS03005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD1_RS03015	COG0138	bifunctional purine biosynthesis protein purh
RD1_RS03030	COG0612	Peptidase, M16
RD1_RS03035	COG0612	Peptidase, M16
RD1_RS03040	COG1012	belongs to the aldehyde dehydrogenase family
RD1_RS03045	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
RD1_RS03050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
RD1_RS03060	COG1312	Catalyzes the dehydration of D-mannonate
RD1_RS03065	COG0673	inositol 2-dehydrogenase activity
RD1_RS03075	COG0673	inositol 2-dehydrogenase activity
RD1_RS03080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS03085	COG0697	spore germination
RD1_RS03105	COG2721	sulfolactate sulfo-lyase activity
RD1_RS03130	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS03140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD1_RS03145	COG2084	Dehydrogenase
RD1_RS03150	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS03155	COG0129	dihydroxy-acid dehydratase activity
RD1_RS03165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RD1_RS03170	COG4948	Mandelate Racemase Muconate Lactonizing
RD1_RS03175	COG3806	Anti-sigma factor
RD1_RS03180	COG1595	DNA-templated transcription, initiation
RD1_RS03205	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS03215	COG0625	glutathione transferase activity
RD1_RS03235	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD1_RS03260	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
RD1_RS03275	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RD1_RS03295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RD1_RS03300	COG0284	orotidine-5'-phosphate decarboxylase activity
RD1_RS03305	COG0542	response to heat
RD1_RS03310	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RD1_RS03325	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RD1_RS03330	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RD1_RS03380	COG2020	methyltransferase activity
RD1_RS03385	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS03405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD1_RS03410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS03415	COG0351	phosphomethylpyrimidine kinase
RD1_RS03430	COG2022	thiamine diphosphate biosynthetic process
RD1_RS03445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RD1_RS03450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RD1_RS03455	COG1116	anion transmembrane transporter activity
RD1_RS03465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS03490	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD1_RS03510	COG2610	gluconate transmembrane transporter activity
RD1_RS03540	COG1131	(ABC) transporter
RD1_RS03545	COG0459	protein refolding
RD1_RS03550	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD1_RS03555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
RD1_RS03620	COG1959	2 iron, 2 sulfur cluster binding
RD1_RS03635	COG1271	oxidase subunit
RD1_RS03640	COG1294	oxidase, subunit
RD1_RS03675	COG0419	ATPase involved in DNA repair
RD1_RS03685	COG1104	cysteine desulfurase activity
RD1_RS03700	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD1_RS03705	COG0556	nucleotide-excision repair
RD1_RS03715	COG0419	ATPase involved in DNA repair
RD1_RS03755	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
RD1_RS03760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD1_RS03780	COG1794	racemase activity, acting on amino acids and derivatives
RD1_RS03785	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RD1_RS03790	COG0583	DNA-binding transcription factor activity
RD1_RS03795	COG0280	phosphate acetyltransferase
RD1_RS03805	COG2855	membrane
RD1_RS03810	COG0028	Belongs to the TPP enzyme family
RD1_RS03815	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS03830	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD1_RS03830	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS03835	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD1_RS03835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS03840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS03845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD1_RS03860	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD1_RS03865	COG1012	belongs to the aldehyde dehydrogenase family
RD1_RS03870	COG3426	butyrate kinase activity
RD1_RS03875	COG0280	phosphate acetyltransferase
RD1_RS03890	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD1_RS03915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RD1_RS03935	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD1_RS03970	COG1129	ABC transporter
RD1_RS03975	COG4214	carbohydrate transport
RD1_RS03980	COG1172	Belongs to the binding-protein-dependent transport system permease family
RD1_RS04000	COG0714	Associated with various cellular activities
RD1_RS04045	COG2205	protein histidine kinase activity
RD1_RS04045	COG2198	Histidine kinase
RD1_RS04045	COG0784	Response regulator, receiver
RD1_RS04075	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD1_RS04080	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
RD1_RS04100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD1_RS04215	COG1840	ABC-type Fe3 transport system, periplasmic component
RD1_RS04225	COG0789	Transcriptional regulator
RD1_RS04230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RD1_RS04235	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RD1_RS04235	COG1321	iron dependent repressor
RD1_RS04240	COG1121	(ABC) transporter
RD1_RS04245	COG0803	Belongs to the bacterial solute-binding protein 9 family
RD1_RS04290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RD1_RS04295	COG2897	thiosulfate sulfurtransferase activity
RD1_RS04305	COG0004	ammonium transporteR
RD1_RS04310	COG0347	Belongs to the P(II) protein family
RD1_RS04345	COG2154	pterin-4-alpha-carbinolamine dehydratase
RD1_RS04350	COG0668	transmembrane transport
RD1_RS04355	COG0678	peroxiredoxin activity
RD1_RS04365	COG0742	ribosomal rna small subunit methyltransferase
RD1_RS04375	COG0024	Methionine aminopeptidase
RD1_RS04380	COG1489	DNA binding
RD1_RS04385	COG1546	Belongs to the CinA family
RD1_RS04385	COG1058	Belongs to the CinA family
RD1_RS04405	COG0583	DNA-binding transcription factor activity
RD1_RS04420	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS04420	COG1902	pentaerythritol trinitrate reductase activity
RD1_RS04430	COG1051	belongs to the nudix hydrolase family
RD1_RS04440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS04445	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RD1_RS04450	COG2169	Transcriptional regulator
RD1_RS04450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD1_RS04455	COG2885	chlorophyll binding
RD1_RS04455	COG3047	cAMP biosynthetic process
RD1_RS04460	COG1053	succinate dehydrogenase
RD1_RS04460	COG3976	FMN-binding domain protein
RD1_RS04460	COG0431	NADPH-dependent FMN reductase
RD1_RS04470	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
RD1_RS04470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS04475	COG0739	heme binding
RD1_RS04475	COG0741	lytic transglycosylase activity
RD1_RS04475	COG1196	nuclear chromosome segregation
RD1_RS04480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
RD1_RS04490	COG0437	4 iron, 4 sulfur cluster binding
RD1_RS04495	COG0243	molybdopterin cofactor binding
RD1_RS04505	COG0028	Belongs to the TPP enzyme family
RD1_RS04510	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
RD1_RS04515	COG2326	polyphosphate kinase activity
RD1_RS04525	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD1_RS04535	COG1116	anion transmembrane transporter activity
RD1_RS04540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS04545	COG3239	Fatty acid desaturase
RD1_RS04550	COG0513	Belongs to the DEAD box helicase family
RD1_RS04570	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS04570	COG1902	pentaerythritol trinitrate reductase activity
RD1_RS04595	COG0825	malonyl-CoA metabolic process
RD1_RS04620	COG4948	Mandelate Racemase Muconate Lactonizing
RD1_RS04640	COG0469	pyruvate kinase activity
RD1_RS04650	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RD1_RS04655	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RD1_RS04665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RD1_RS04675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD1_RS04675	COG0072	phenylalanine-tRNA ligase activity
RD1_RS04685	COG1970	mechanosensitive ion channel activity
RD1_RS04755	COG4638	Rieske (2fe-2S)
RD1_RS04765	COG0686	Belongs to the AlaDH PNT family
RD1_RS04770	COG1522	sequence-specific DNA binding
RD1_RS04780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RD1_RS04790	COG1063	alcohol dehydrogenase
RD1_RS04810	COG0251	oxidation-reduction process
RD1_RS04815	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RD1_RS04820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RD1_RS04825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RD1_RS04830	COG1063	alcohol dehydrogenase
RD1_RS04835	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS04845	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS04850	COG1802	Transcriptional regulator
RD1_RS04860	COG3639	organic phosphonate transmembrane transporter activity
RD1_RS04865	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD1_RS04875	COG1840	ABC-type Fe3 transport system, periplasmic component
RD1_RS04885	COG3842	ATPase activity
RD1_RS04905	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
RD1_RS04915	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD1_RS04920	COG5328	Belongs to the UPF0262 family
RD1_RS04975	COG0481	GTPase activity
RD1_RS05035	COG0668	transmembrane transport
RD1_RS05045	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD1_RS05050	COG0601	transmembrane transport
RD1_RS05055	COG0747	negative chemotaxis
RD1_RS05060	COG4172	Belongs to the ABC transporter superfamily
RD1_RS05075	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS05085	COG1063	alcohol dehydrogenase
RD1_RS05090	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS05100	COG2176	DNA-directed DNA polymerase activity
RD1_RS05100	COG5002	protein histidine kinase activity
RD1_RS05115	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RD1_RS05125	COG0563	adenylate kinase activity
RD1_RS05130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD1_RS05135	COG1376	ErfK ybiS ycfS ynhG family protein
RD1_RS05140	COG2962	Rard protein
RD1_RS05145	COG2951	lytic endotransglycosylase activity
RD1_RS05165	COG2274	protein secretion by the type I secretion system
RD1_RS05170	COG1538	Outer membrane efflux protein
RD1_RS05185	COG3257	ureidoglycine aminohydrolase activity
RD1_RS05190	COG1045	serine acetyltransferase
RD1_RS05200	COG1942	4-Oxalocrotonate Tautomerase
RD1_RS05215	COG0583	DNA-binding transcription factor activity
RD1_RS05220	COG1309	transcriptional regulator
RD1_RS05250	COG2801	Transposase and inactivated derivatives
RD1_RS05265	COG2801	Transposase and inactivated derivatives
RD1_RS05285	COG0535	radical SAM domain protein
RD1_RS05290	COG0535	radical SAM domain protein
RD1_RS05295	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
RD1_RS05300	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RD1_RS05310	COG0745	RESPONSE REGULATOR receiver
RD1_RS05315	COG5002	protein histidine kinase activity
RD1_RS05315	COG3850	Histidine kinase
RD1_RS05330	COG1131	(ABC) transporter
RD1_RS05345	COG0045	succinate-CoA ligase (ADP-forming) activity
RD1_RS05350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD1_RS05360	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD1_RS05375	COG0840	transmembrane signaling receptor activity
RD1_RS05380	COG0583	DNA-binding transcription factor activity
RD1_RS05420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RD1_RS05435	COG0346	lactoylglutathione lyase activity
RD1_RS05450	COG0778	Nitroreductase
RD1_RS05460	COG0180	Tryptophanyl-tRNA synthetase
RD1_RS05470	COG0728	peptidoglycan biosynthetic process
RD1_RS05475	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
RD1_RS05485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RD1_RS05490	COG0792	nuclease activity
RD1_RS05495	COG0189	ligase activity
RD1_RS05500	COG0606	chelatase, subunit chli
RD1_RS05530	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
RD1_RS05535	COG0756	dUTP diphosphatase activity
RD1_RS05540	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
RD1_RS05545	COG0339	signal peptide processing
RD1_RS05550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RD1_RS05555	COG0772	Belongs to the SEDS family
RD1_RS05560	COG0768	penicillin binding
RD1_RS05585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD1_RS05595	COG3046	protein related to deoxyribodipyrimidine photolyase
RD1_RS05620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD1_RS05625	COG0534	Mate efflux family protein
RD1_RS05635	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS05640	COG0509	glycine decarboxylation via glycine cleavage system
RD1_RS05645	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD1_RS05645	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
RD1_RS05655	COG4181	ATPase activity
RD1_RS05665	COG1278	Cold shock
RD1_RS05680	COG1278	Cold shock
RD1_RS05705	COG0488	(ABC) transporter
RD1_RS05725	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
RD1_RS05730	COG2027	D-alanyl-D-alanine carboxypeptidase
RD1_RS05740	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
RD1_RS05785	COG0556	nucleotide-excision repair
RD1_RS05800	COG0737	Belongs to the 5'-nucleotidase family
RD1_RS05805	COG2816	NAD+ diphosphatase activity
RD1_RS05815	COG1605	Chorismate mutase
RD1_RS05815	COG0077	Prephenate dehydratase
RD1_RS05830	COG4174	ABC transporter (Permease)
RD1_RS05835	COG4239	(ABC) transporter, permease
RD1_RS05840	COG4172	Belongs to the ABC transporter superfamily
RD1_RS05845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD1_RS05850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD1_RS05875	COG2010	Cytochrome c
RD1_RS05880	COG0348	domain, Protein
RD1_RS05900	COG1686	Belongs to the peptidase S11 family
RD1_RS05905	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RD1_RS05910	COG2813	Specifically methylates the guanine in position
RD1_RS05920	COG0408	coproporphyrinogen oxidase activity
RD1_RS05925	COG0181	hydroxymethylbilane synthase activity
RD1_RS05930	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
RD1_RS05940	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS06000	COG2151	metal-sulfur cluster biosynthetic enzyme
RD1_RS06000	COG0489	protein tyrosine kinase activity
RD1_RS06025	COG0254	rRNA binding
RD1_RS06030	COG0335	large ribosomal subunit rRNA binding
RD1_RS06040	COG0336	Belongs to the RNA methyltransferase TrmD family
RD1_RS06045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RD1_RS06050	COG0228	four-way junction DNA binding
RD1_RS06070	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RD1_RS06100	COG0356	it plays a direct role in the translocation of protons across the membrane
RD1_RS06105	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD1_RS06110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD1_RS06115	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RD1_RS06120	COG2186	Transcriptional regulator
RD1_RS06140	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
RD1_RS06155	COG0435	Glutathione S-transferase
RD1_RS06165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
RD1_RS06170	COG0242	peptide deformylase activity
RD1_RS06175	COG0242	peptide deformylase activity
RD1_RS06180	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RD1_RS06190	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD1_RS06225	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD1_RS06235	COG2860	membrane
RD1_RS06240	COG0328	RNA-DNA hybrid ribonuclease activity
RD1_RS06245	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
RD1_RS06260	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
RD1_RS06270	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RD1_RS06275	COG1758	RNA polymerase activity
RD1_RS06290	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
RD1_RS06300	COG0736	holo-[acyl-carrier-protein] synthase activity
RD1_RS06305	COG0681	Belongs to the peptidase S26 family
RD1_RS06310	COG0571	ribonuclease III activity
RD1_RS06315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
RD1_RS06325	COG1381	Involved in DNA repair and RecF pathway recombination
RD1_RS06360	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
RD1_RS06365	COG0745	RESPONSE REGULATOR receiver
RD1_RS06370	COG2205	protein histidine kinase activity
RD1_RS06375	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
RD1_RS06380	COG1660	Displays ATPase and GTPase activities
RD1_RS06400	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD1_RS06420	COG2096	Adenosyltransferase
RD1_RS06430	COG0300	oxidoreductase activity
RD1_RS06440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RD1_RS06445	COG2124	cytochrome p450
RD1_RS06455	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD1_RS06470	COG0051	transcription antitermination factor activity, RNA binding
RD1_RS06475	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RD1_RS06480	COG0088	Forms part of the polypeptide exit tunnel
RD1_RS06485	COG0089	rRNA binding
RD1_RS06490	COG1278	Cold shock
RD1_RS06505	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
RD1_RS06510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RD1_RS06515	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RD1_RS06520	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RD1_RS06525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RD1_RS06550	COG0010	Belongs to the arginase family
RD1_RS06560	COG0255	Belongs to the universal ribosomal protein uL29 family
RD1_RS06565	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RD1_RS06570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RD1_RS06575	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RD1_RS06580	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RD1_RS06585	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RD1_RS06590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RD1_RS06595	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RD1_RS06600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RD1_RS06605	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RD1_RS06610	COG1841	ribosomal large subunit assembly
RD1_RS06625	COG0200	Binds to the 23S rRNA
RD1_RS06630	COG0201	protein transport
RD1_RS06635	COG0563	adenylate kinase activity
RD1_RS06645	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
RD1_RS06650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RD1_RS06655	COG0202	RNA polymerase activity
RD1_RS06660	COG0203	ribosomal protein L17
RD1_RS06665	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RD1_RS06670	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
RD1_RS06675	COG0564	pseudouridine synthase activity
RD1_RS06680	COG0546	phosphoglycolate phosphatase activity
RD1_RS06690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RD1_RS06695	COG4597	amino acid ABC transporter
RD1_RS06700	COG0765	amino acid transport
RD1_RS06705	COG1126	abc transporter atp-binding protein
RD1_RS06710	COG0406	alpha-ribazole phosphatase activity
RD1_RS06725	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RD1_RS06730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
RD1_RS06740	COG0706	membrane insertase activity
RD1_RS06745	COG3300	MHYT domain
RD1_RS06745	COG5001	Diguanylate cyclase
RD1_RS06750	COG0037	tRNA processing
RD1_RS06755	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RD1_RS06760	COG0594	ribonuclease P activity
RD1_RS06765	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RD1_RS06780	COG3852	Histidine kinase
RD1_RS06820	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS06840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS06870	COG1175	transmembrane transport
RD1_RS06880	COG1609	Transcriptional regulator
RD1_RS06885	COG4251	negative regulation of phosphorylation
RD1_RS06900	COG2201	protein-glutamate methylesterase activity
RD1_RS06920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RD1_RS06925	COG0174	glutamine synthetase
RD1_RS06940	COG1335	isochorismatase
RD1_RS06970	COG2391	methyltransferase activity
RD1_RS06985	COG0785	Cytochrome C biogenesis protein
RD1_RS07010	COG3258	Cytochrome c
RD1_RS07015	COG0737	Belongs to the 5'-nucleotidase family
RD1_RS07030	COG3474	cytochrome
RD1_RS07035	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS07045	COG2391	methyltransferase activity
RD1_RS07065	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS07075	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RD1_RS07075	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RD1_RS07085	COG1846	Transcriptional regulator
RD1_RS07120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS07130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS07160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
RD1_RS07205	COG0714	Associated with various cellular activities
RD1_RS07225	COG0348	domain, Protein
RD1_RS07225	COG3901	Regulator of nitric oxide reductase transcription
RD1_RS07230	COG2010	Cytochrome c
RD1_RS07235	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD1_RS07240	COG2010	Cytochrome c
RD1_RS07245	COG3391	amine dehydrogenase activity
RD1_RS07265	COG0535	radical SAM domain protein
RD1_RS07285	COG0156	8-amino-7-oxononanoate synthase activity
RD1_RS07290	COG0463	Glycosyl transferase, family 2
RD1_RS07300	COG1215	transferase activity, transferring glycosyl groups
RD1_RS07325	COG0667	Aldo Keto reductase
RD1_RS07345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD1_RS07350	COG0165	Argininosuccinate lyase
RD1_RS07360	COG0019	diaminopimelate decarboxylase activity
RD1_RS07375	COG2884	Cell division ATP-binding protein ftsE
RD1_RS07420	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD1_RS07425	COG0567	Dehydrogenase, E1 component
RD1_RS07455	COG0045	succinate-CoA ligase (ADP-forming) activity
RD1_RS07465	COG0039	L-malate dehydrogenase activity
RD1_RS07495	COG2030	dehydratase
RD1_RS07550	COG0813	purine-nucleoside phosphorylase activity
RD1_RS07555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RD1_RS07555	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RD1_RS07565	COG2937	Belongs to the GPAT DAPAT family
RD1_RS07570	COG0604	alcohol dehydrogenase
RD1_RS07585	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RD1_RS07595	COG0730	response to heat
RD1_RS07600	COG1079	Belongs to the binding-protein-dependent transport system permease family
RD1_RS07605	COG4603	Belongs to the binding-protein-dependent transport system permease family
RD1_RS07610	COG3845	ABC transporter
RD1_RS07615	COG1744	ABC transporter substrate-binding protein PnrA-like
RD1_RS07630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
RD1_RS07670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD1_RS07680	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RD1_RS07710	COG2943	transferase activity, transferring hexosyl groups
RD1_RS07715	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
RD1_RS07730	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD1_RS07735	COG0028	Belongs to the TPP enzyme family
RD1_RS07745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RD1_RS07750	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RD1_RS07755	COG1643	Atp-dependent helicase
RD1_RS07760	COG1703	isobutyryl-CoA mutase activity
RD1_RS07765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RD1_RS07780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
RD1_RS07785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
RD1_RS07790	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RD1_RS07795	COG0424	maF-like protein
RD1_RS07805	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
RD1_RS07810	COG0475	glutathione-regulated potassium exporter activity
RD1_RS07815	COG1959	2 iron, 2 sulfur cluster binding
RD1_RS07835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RD1_RS07840	COG1032	radical SAM domain protein
RD1_RS07870	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS07870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS07880	COG2814	Major facilitator Superfamily
RD1_RS07910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS07920	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD1_RS07930	COG4618	COG4618 ABC-type protease lipase transport system, ATPase and permease components
RD1_RS07950	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
RD1_RS07960	COG2188	Transcriptional regulator
RD1_RS07970	COG1653	transport
RD1_RS07975	COG1175	transmembrane transport
RD1_RS07980	COG0395	ABC-type sugar transport system, permease component
RD1_RS07985	COG0673	inositol 2-dehydrogenase activity
RD1_RS08010	COG1136	(ABC) transporter
RD1_RS08010	COG0577	efflux transmembrane transporter activity
RD1_RS08025	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD1_RS08050	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RD1_RS08055	COG0354	folic acid binding
RD1_RS08065	COG1132	(ABC) transporter
RD1_RS08070	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RD1_RS08080	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD1_RS08090	COG0525	valine-tRNA ligase activity
RD1_RS08125	COG0583	DNA-binding transcription factor activity
RD1_RS08140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
RD1_RS08145	COG4235	cytochrome complex assembly
RD1_RS08185	COG5265	(ABC) transporter
RD1_RS08200	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
RD1_RS08220	COG1160	GTP binding
RD1_RS08240	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
RD1_RS08245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS08250	COG4311	Sarcosine oxidase, delta subunit
RD1_RS08255	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS08255	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS08270	COG0358	DNA primase activity
RD1_RS08275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RD1_RS08295	COG0432	Pfam Uncharacterised protein family UPF0047
RD1_RS08300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
RD1_RS08305	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD1_RS08305	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RD1_RS08315	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD1_RS08315	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RD1_RS08320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RD1_RS08325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RD1_RS08365	COG0564	pseudouridine synthase activity
RD1_RS08385	COG1793	dna ligase
RD1_RS08415	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RD1_RS08420	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
RD1_RS08425	COG1329	Transcriptional regulator
RD1_RS08430	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
RD1_RS08435	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
RD1_RS08465	COG2873	o-acetylhomoserine
RD1_RS08475	COG0583	DNA-binding transcription factor activity
RD1_RS08480	COG2515	1-aminocyclopropane-1-carboxylate deaminase
RD1_RS08490	COG4175	Glycine betaine
RD1_RS08490	COG3448	diguanylate cyclase activity
RD1_RS08495	COG4176	ABC-type proline glycine betaine transport system permease component
RD1_RS08515	COG2801	Transposase and inactivated derivatives
RD1_RS08555	COG2801	Transposase and inactivated derivatives
RD1_RS08575	COG1959	2 iron, 2 sulfur cluster binding
RD1_RS08580	COG0523	cobalamin synthesis protein
RD1_RS08605	COG4608	Belongs to the ABC transporter superfamily
RD1_RS08615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD1_RS08635	COG3181	Tripartite tricarboxylate transporter family receptor
RD1_RS08640	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS08645	COG1846	Transcriptional regulator
RD1_RS08665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
RD1_RS08675	COG1278	Cold shock
RD1_RS08680	COG1393	Belongs to the ArsC family
RD1_RS08695	COG3220	belongs to the UPF0276 family
RD1_RS08705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
RD1_RS08730	COG3243	poly(R)-hydroxyalkanoic acid synthase
RD1_RS08745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS08750	COG0174	glutamine synthetase
RD1_RS08755	COG0519	Catalyzes the synthesis of GMP from XMP
RD1_RS08760	COG0174	glutamine synthetase
RD1_RS08765	COG4160	amino acid transport
RD1_RS08770	COG4215	(ABC) transporter
RD1_RS08800	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
RD1_RS08810	COG0504	CTP synthase activity
RD1_RS08845	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
RD1_RS08870	COG1760	l-serine dehydratase
RD1_RS08875	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
RD1_RS08885	COG0330	HflC and HflK could
RD1_RS08890	COG0330	HflC and HflK could
RD1_RS08905	COG0587	DNA-directed DNA polymerase activity
RD1_RS08920	COG0151	Belongs to the GarS family
RD1_RS08925	COG1570	exodeoxyribonuclease VII activity
RD1_RS08935	COG0552	protein localization to endoplasmic reticulum
RD1_RS08945	COG2917	probably involved in intracellular septation
RD1_RS08955	COG0625	glutathione transferase activity
RD1_RS08970	COG1469	GTP cyclohydrolase I activity
RD1_RS08975	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RD1_RS08990	COG0752	glycyl-tRNA synthetase alpha subunit
RD1_RS09000	COG0751	glycine-tRNA ligase activity
RD1_RS09005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD1_RS09005	COG0574	Belongs to the PEP-utilizing enzyme family
RD1_RS09015	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
RD1_RS09020	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RD1_RS09025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RD1_RS09035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RD1_RS09070	COG1802	Transcriptional regulator
RD1_RS09080	COG0505	Belongs to the CarA family
RD1_RS09085	COG1610	YqeY-like protein
RD1_RS09090	COG2378	regulation of single-species biofilm formation
RD1_RS09115	COG0321	lipoyl(octanoyl) transferase activity
RD1_RS09130	COG1132	(ABC) transporter
RD1_RS09135	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS09145	COG4172	Belongs to the ABC transporter superfamily
RD1_RS09150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD1_RS09170	COG2379	hydroxypyruvate reductase
RD1_RS09175	COG1490	D-aminoacyl-tRNA deacylase activity
RD1_RS09200	COG3853	Toxic anion resistance protein (TelA)
RD1_RS09210	COG1187	pseudouridine synthase activity
RD1_RS09215	COG0590	tRNA wobble adenosine to inosine editing
RD1_RS09220	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
RD1_RS09230	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RD1_RS09240	COG3023	N-Acetylmuramoyl-L-alanine amidase
RD1_RS09250	COG0154	amidase activity
RD1_RS09255	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD1_RS09260	COG0670	Belongs to the BI1 family
RD1_RS09270	COG0583	DNA-binding transcription factor activity
RD1_RS09275	COG1396	sequence-specific DNA binding
RD1_RS09280	COG0483	inositol monophosphate 1-phosphatase activity
RD1_RS09290	COG0402	S-adenosylhomocysteine deaminase activity
RD1_RS09295	COG2239	Acts as a magnesium transporter
RD1_RS09305	COG1692	metallophosphoesterase
RD1_RS09315	COG3273	potassium ion transport
RD1_RS09315	COG0471	metal ion transport
RD1_RS09325	COG0490	domain, Protein
RD1_RS09325	COG0471	metal ion transport
RD1_RS09335	COG0217	transcriptional regulatory protein
RD1_RS09345	COG0697	spore germination
RD1_RS09350	COG1309	transcriptional regulator
RD1_RS09355	COG3119	arylsulfatase activity
RD1_RS09380	COG1396	sequence-specific DNA binding
RD1_RS09380	COG3800	Transcriptional regulator
RD1_RS09385	COG2814	Major facilitator Superfamily
RD1_RS09390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD1_RS09410	COG4770	biotin carboxylase activity
RD1_RS09425	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RD1_RS09425	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
RD1_RS09440	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RD1_RS09450	COG0248	Ppx GppA phosphatase
RD1_RS09455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RD1_RS09465	COG0628	permease
RD1_RS09470	COG0442	prolyl-tRNA aminoacylation
RD1_RS09485	COG1136	(ABC) transporter
RD1_RS09490	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
RD1_RS09510	COG2010	Cytochrome c
RD1_RS09525	COG0187	DNA topoisomerase II activity
RD1_RS09540	COG0534	Mate efflux family protein
RD1_RS09550	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RD1_RS09565	COG1960	acyl-CoA dehydrogenase activity
RD1_RS09585	COG0101	tRNA pseudouridine synthase activity
RD1_RS09590	COG3106	COG3106 Predicted ATPase
RD1_RS09600	COG3768	UPF0283 membrane protein
RD1_RS09605	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RD1_RS09610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RD1_RS09615	COG1183	phosphatidylcholine synthase activity
RD1_RS09630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
RD1_RS09665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
RD1_RS09670	COG0632	four-way junction helicase activity
RD1_RS09675	COG2255	four-way junction helicase activity
RD1_RS09685	COG0824	Thioesterase
RD1_RS09705	COG0823	Involved in the tonB-independent uptake of proteins
RD1_RS09710	COG2885	chlorophyll binding
RD1_RS09720	COG0037	tRNA processing
RD1_RS09725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RD1_RS09740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD1_RS09755	COG1201	RNA secondary structure unwinding
RD1_RS09805	COG4964	Belongs to the GSP D family
RD1_RS09835	COG3920	Histidine kinase
RD1_RS09845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RD1_RS09850	COG0758	DNA mediated transformation
RD1_RS09855	COG0312	modulator of DNA gyrase
RD1_RS09865	COG0109	protoheme IX farnesyltransferase activity
RD1_RS09875	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
RD1_RS09885	COG3346	SURF1 family
RD1_RS09895	COG0612	Peptidase, M16
RD1_RS09920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD1_RS09925	COG1280	lysine exporter protein (LysE YggA)
RD1_RS09930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
RD1_RS09935	COG0659	secondary active sulfate transmembrane transporter activity
RD1_RS09965	COG0527	aspartate kinase activity
RD1_RS09970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
RD1_RS09975	COG3180	Ammonia monooxygenase
RD1_RS09985	COG0840	transmembrane signaling receptor activity
RD1_RS10000	COG1172	Belongs to the binding-protein-dependent transport system permease family
RD1_RS10030	COG0174	glutamine synthetase
RD1_RS10065	COG1492	cobalamin metabolic process
RD1_RS10080	COG0765	amino acid transport
RD1_RS10085	COG1126	abc transporter atp-binding protein
RD1_RS10110	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS10110	COG1902	pentaerythritol trinitrate reductase activity
RD1_RS10125	COG0346	lactoylglutathione lyase activity
RD1_RS10140	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
RD1_RS10150	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
RD1_RS10175	COG1396	sequence-specific DNA binding
RD1_RS10175	COG3800	Transcriptional regulator
RD1_RS10190	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD1_RS10200	COG0483	inositol monophosphate 1-phosphatase activity
RD1_RS10205	COG0572	uridine kinase
RD1_RS10250	COG4608	Belongs to the ABC transporter superfamily
RD1_RS10255	COG0444	Belongs to the ABC transporter superfamily
RD1_RS10270	COG0747	negative chemotaxis
RD1_RS10275	COG0747	negative chemotaxis
RD1_RS10285	COG0582	viral genome integration into host DNA
RD1_RS10325	COG3380	Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P) . May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers
RD1_RS10330	COG1136	(ABC) transporter
RD1_RS10335	COG0577	efflux transmembrane transporter activity
RD1_RS10350	COG2201	protein-glutamate methylesterase activity
RD1_RS10360	COG2801	Transposase and inactivated derivatives
RD1_RS10395	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RD1_RS10400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RD1_RS10405	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
RD1_RS10415	COG2166	iron-sulfur cluster assembly
RD1_RS10425	COG5012	cobalamin binding
RD1_RS10430	COG0646	methionine synthase
RD1_RS10430	COG1410	methionine synthase
RD1_RS10440	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RD1_RS10445	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD1_RS10450	COG0047	phosphoribosylformylglycinamidine synthase activity
RD1_RS10465	COG1530	ribonuclease E activity
RD1_RS10470	COG0425	Belongs to the sulfur carrier protein TusA family
RD1_RS10475	COG0785	Cytochrome C biogenesis protein
RD1_RS10480	COG3588	fructose-bisphosphate aldolase
RD1_RS10495	COG0114	fumarate hydratase activity
RD1_RS10530	COG2186	Transcriptional regulator
RD1_RS10550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS10555	COG0604	alcohol dehydrogenase
RD1_RS10560	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD1_RS10565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
RD1_RS10570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD1_RS10575	COG0415	Belongs to the DNA photolyase family
RD1_RS10580	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RD1_RS10590	COG0494	nUDIX hydrolase
RD1_RS10600	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
RD1_RS10600	COG3264	Mechanosensitive ion channel
RD1_RS10625	COG2132	Multicopper oxidase
RD1_RS10635	COG0673	inositol 2-dehydrogenase activity
RD1_RS10645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
RD1_RS10650	COG4989	oxidoreductase activity
RD1_RS10665	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD1_RS10665	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS10670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS10685	COG2723	6-phospho-beta-galactosidase activity
RD1_RS10690	COG1609	Transcriptional regulator
RD1_RS10695	COG1653	transport
RD1_RS10700	COG1175	transmembrane transport
RD1_RS10710	COG0366	Alpha amylase catalytic
RD1_RS10715	COG3842	ATPase activity
RD1_RS10725	COG0729	surface antigen
RD1_RS10735	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
RD1_RS10740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
RD1_RS10755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS10765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD1_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS10785	COG0438	transferase activity, transferring glycosyl groups
RD1_RS10790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS10795	COG1116	anion transmembrane transporter activity
RD1_RS10820	COG2353	YceI-like domain
RD1_RS10835	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD1_RS10890	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS10900	COG0583	DNA-binding transcription factor activity
RD1_RS10905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
RD1_RS10945	COG1129	ABC transporter
RD1_RS10955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
RD1_RS10960	COG2390	Transcriptional regulator
RD1_RS10965	COG3454	Phosphonate metabolism
RD1_RS10980	COG4778	phosphonate C-P lyase system protein PhnL
RD1_RS10985	COG4107	phosphonate C-P lyase system protein PhnK
RD1_RS10990	COG3627	carbon phosphorus lyase activity
RD1_RS10995	COG3626	phosphonate metabolism
RD1_RS11000	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
RD1_RS11005	COG3624	Phosphonate C-P lyase system protein PhnG
RD1_RS11010	COG2188	Transcriptional regulator
RD1_RS11020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RD1_RS11035	COG3639	organic phosphonate transmembrane transporter activity
RD1_RS11040	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
RD1_RS11045	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
RD1_RS11060	COG0154	amidase activity
RD1_RS11065	COG1177	transmembrane transport
RD1_RS11070	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS11075	COG3842	ATPase activity
RD1_RS11090	COG1177	transmembrane transport
RD1_RS11095	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS11100	COG3842	ATPase activity
RD1_RS11110	COG1349	DNA-binding transcription factor activity
RD1_RS11145	COG0402	S-adenosylhomocysteine deaminase activity
RD1_RS11150	COG3842	ATPase activity
RD1_RS11160	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS11165	COG1177	transmembrane transport
RD1_RS11180	COG3655	Transcriptional regulator
RD1_RS11210	COG2223	nitrite transmembrane transporter activity
RD1_RS11215	COG2223	nitrite transmembrane transporter activity
RD1_RS11220	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
RD1_RS11225	COG1140	nitrate reductase beta subunit
RD1_RS11230	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
RD1_RS11235	COG2181	nitrate reductase activity
RD1_RS11255	COG0303	'Molybdopterin
RD1_RS11260	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD1_RS11260	COG1618	nucleotide phosphatase activity, acting on free nucleotides
RD1_RS11275	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
RD1_RS11280	COG1285	pathogenesis
RD1_RS11285	COG0668	transmembrane transport
RD1_RS11325	COG0784	Response regulator, receiver
RD1_RS11335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RD1_RS11340	COG2116	formate transmembrane transporter activity
RD1_RS11355	COG0534	Mate efflux family protein
RD1_RS11380	COG0628	permease
RD1_RS11430	COG0210	DNA helicase
RD1_RS11435	COG2801	Transposase and inactivated derivatives
RD1_RS11470	COG1309	transcriptional regulator
RD1_RS11520	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD1_RS11530	COG0483	inositol monophosphate 1-phosphatase activity
RD1_RS11545	COG1522	sequence-specific DNA binding
RD1_RS11560	COG0840	transmembrane signaling receptor activity
RD1_RS11575	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD1_RS11585	COG2353	YceI-like domain
RD1_RS11595	COG0667	Aldo Keto reductase
RD1_RS11600	COG3246	L-lysine catabolic process to acetate
RD1_RS11610	COG0824	Thioesterase
RD1_RS11610	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD1_RS11680	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
RD1_RS11705	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
RD1_RS11710	COG3591	Belongs to the peptidase S1B family
RD1_RS11715	COG1862	Preprotein translocase
RD1_RS11720	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD1_RS11725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RD1_RS11730	COG3737	Protein of unknown function (DUF498/DUF598)
RD1_RS11735	COG4133	protoheme IX ABC transporter activity
RD1_RS11740	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD1_RS11745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RD1_RS11755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
RD1_RS11760	COG3842	ATPase activity
RD1_RS11790	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RD1_RS11795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RD1_RS11805	COG1268	BioY protein
RD1_RS11830	COG0006	proline dipeptidase activity
RD1_RS11850	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RD1_RS11855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RD1_RS11855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RD1_RS11870	COG0629	single-stranded DNA binding
RD1_RS11875	COG0741	lytic transglycosylase activity
RD1_RS11885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD1_RS11890	COG0601	transmembrane transport
RD1_RS11900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
RD1_RS11905	COG0528	UMP kinase activity
RD1_RS11910	COG0233	cytoplasmic translational termination
RD1_RS11915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
RD1_RS11925	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RD1_RS11930	COG0750	zinc metalloprotease
RD1_RS11935	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD1_RS11945	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD1_RS11950	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD1_RS11955	COG3494	Protein of unknown function (DUF1009)
RD1_RS11960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD1_RS11965	COG0482	sulfurtransferase activity
RD1_RS11975	COG0745	RESPONSE REGULATOR receiver
RD1_RS11980	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
RD1_RS12005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RD1_RS12010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD1_RS12020	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
RD1_RS12035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RD1_RS12060	COG2989	Protein conserved in bacteria
RD1_RS12065	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RD1_RS12070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD1_RS12085	COG0433	COG0433 Predicted ATPase
RD1_RS12110	COG0683	leucine binding
RD1_RS12115	COG2133	pyrroloquinoline quinone binding
RD1_RS12125	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RD1_RS12135	COG1561	YicC-like family, N-terminal region
RD1_RS12140	COG0194	GDP metabolic process
RD1_RS12150	COG0626	cystathionine gamma-synthase activity
RD1_RS12155	COG5002	protein histidine kinase activity
RD1_RS12165	COG0573	inorganic phosphate transmembrane transporter activity
RD1_RS12175	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
RD1_RS12180	COG0704	Plays a role in the regulation of phosphate uptake
RD1_RS12185	COG0745	RESPONSE REGULATOR receiver
RD1_RS12200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RD1_RS12205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RD1_RS12210	COG0052	Belongs to the universal ribosomal protein uS2 family
RD1_RS12235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RD1_RS12240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
RD1_RS12245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
RD1_RS12260	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RD1_RS12265	COG3743	rRNA binding
RD1_RS12265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD1_RS12305	COG4139	cobalamin transport
RD1_RS12310	COG1120	ATPase activity
RD1_RS12345	COG2066	Belongs to the glutaminase family
RD1_RS12360	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RD1_RS12370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RD1_RS12385	COG0719	Fe-S assembly protein
RD1_RS12390	COG0396	ATPase activity
RD1_RS12395	COG0393	Putative heavy-metal-binding
RD1_RS12400	COG0719	Fe-S assembly protein
RD1_RS12410	COG1959	2 iron, 2 sulfur cluster binding
RD1_RS12415	COG2945	thiolester hydrolase activity
RD1_RS12430	COG0538	isocitrate dehydrogenase activity
RD1_RS12440	COG1217	gtp-binding protein TYPA
RD1_RS12450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RD1_RS12455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RD1_RS12470	COG0517	IMP dehydrogenase activity
RD1_RS12470	COG0516	GMP reductase activity
RD1_RS12495	COG0166	Belongs to the GPI family
RD1_RS12505	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
RD1_RS12515	COG5425	PFAM Usg family protein
RD1_RS12525	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
RD1_RS12530	COG1612	heme a metabolic process
RD1_RS12540	COG0352	thiamine-phosphate diphosphorylase activity
RD1_RS12560	COG2313	pseudouridylate synthase activity
RD1_RS12575	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS12580	COG4166	transmembrane transport
RD1_RS12600	COG2814	Major facilitator Superfamily
RD1_RS12605	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RD1_RS12625	COG2084	Dehydrogenase
RD1_RS12630	COG2366	antibiotic biosynthetic process
RD1_RS12640	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
RD1_RS12645	COG1923	regulation of RNA biosynthetic process
RD1_RS12650	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RD1_RS12655	COG0569	domain protein
RD1_RS12670	COG2204	response regulator
RD1_RS12675	COG5000	phosphorelay sensor kinase activity
RD1_RS12680	COG2204	response regulator
RD1_RS12685	COG3852	Histidine kinase
RD1_RS12690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RD1_RS12695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RD1_RS12700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RD1_RS12705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RD1_RS12710	COG1546	Belongs to the CinA family
RD1_RS12715	COG2867	negative regulation of translational initiation
RD1_RS12720	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
RD1_RS12730	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
RD1_RS12755	COG0518	GMP synthase (glutamine-hydrolyzing) activity
RD1_RS12755	COG0519	Catalyzes the synthesis of GMP from XMP
RD1_RS12760	COG0697	spore germination
RD1_RS12780	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
RD1_RS12785	COG0596	Alpha beta hydrolase
RD1_RS12790	COG2326	polyphosphate kinase activity
RD1_RS12795	COG1309	transcriptional regulator
RD1_RS12805	COG3932	Exopolysaccharide synthesis, ExoD
RD1_RS12815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
RD1_RS12825	COG0542	response to heat
RD1_RS12830	COG0454	-acetyltransferase
RD1_RS12830	COG0456	acetyltransferase
RD1_RS12860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
RD1_RS12870	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
RD1_RS12885	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RD1_RS12890	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS12900	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD1_RS12920	COG0028	Belongs to the TPP enzyme family
RD1_RS12930	COG0440	acetolactate synthase activity
RD1_RS12960	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
RD1_RS12965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
RD1_RS12970	COG0860	N-Acetylmuramoyl-L-alanine amidase
RD1_RS12975	COG0436	Aminotransferase
RD1_RS12990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RD1_RS13000	COG0156	8-amino-7-oxononanoate synthase activity
RD1_RS13005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RD1_RS13020	COG1741	Belongs to the pirin family
RD1_RS13035	COG0406	alpha-ribazole phosphatase activity
RD1_RS13040	COG3750	Belongs to the UPF0335 family
RD1_RS13070	COG0745	RESPONSE REGULATOR receiver
RD1_RS13100	COG0410	ABC transporter
RD1_RS13115	COG0511	ligase activity, forming carbon-carbon bonds
RD1_RS13120	COG0439	Biotin carboxylase
RD1_RS13125	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RD1_RS13150	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RD1_RS13155	COG0740	serine-type endopeptidase activity
RD1_RS13170	COG1414	Transcriptional regulator
RD1_RS13180	COG1175	transmembrane transport
RD1_RS13185	COG0395	ABC-type sugar transport system, permease component
RD1_RS13195	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS13200	COG3734	2-keto-3-deoxy-galactonokinase
RD1_RS13205	COG0800	Aldolase
RD1_RS13215	COG0033	Phosphoglucomutase
RD1_RS13230	COG0297	glycogen (starch) synthase activity
RD1_RS13235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
RD1_RS13240	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
RD1_RS13245	COG0058	SHG alpha-glucan phosphorylase activity
RD1_RS13255	COG0800	Aldolase
RD1_RS13260	COG0129	dihydroxy-acid dehydratase activity
RD1_RS13270	COG1454	alcohol dehydrogenase
RD1_RS13275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
RD1_RS13285	COG1349	DNA-binding transcription factor activity
RD1_RS13295	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
RD1_RS13300	COG2423	ornithine cyclodeaminase activity
RD1_RS13305	COG3616	Alanine racemase, N-terminal domain
RD1_RS13310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RD1_RS13315	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
RD1_RS13320	COG1414	Transcriptional regulator
RD1_RS13325	COG1802	Transcriptional regulator
RD1_RS13335	COG0437	4 iron, 4 sulfur cluster binding
RD1_RS13340	COG0243	molybdopterin cofactor binding
RD1_RS13340	COG3383	formate dehydrogenase (NAD+) activity
RD1_RS13380	COG0489	protein tyrosine kinase activity
RD1_RS13415	COG0725	ABC transporter, periplasmic molybdate-binding protein
RD1_RS13420	COG4149	molybdate abc transporter
RD1_RS13425	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD1_RS13435	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS13440	COG1012	belongs to the aldehyde dehydrogenase family
RD1_RS13465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RD1_RS13470	COG0022	dehydrogenase e1 component
RD1_RS13475	COG1672	PFAM Archaeal ATPase
RD1_RS13475	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
RD1_RS13490	COG4176	ABC-type proline glycine betaine transport system permease component
RD1_RS13495	COG0517	IMP dehydrogenase activity
RD1_RS13495	COG4175	Glycine betaine
RD1_RS13500	COG0246	Mannitol dehydrogenase
RD1_RS13505	COG1904	glucuronate isomerase
RD1_RS13515	COG3842	ATPase activity
RD1_RS13520	COG0395	ABC-type sugar transport system, permease component
RD1_RS13525	COG1175	transmembrane transport
RD1_RS13545	COG0642	Histidine kinase
RD1_RS13570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD1_RS13580	COG0343	queuine tRNA-ribosyltransferase activity
RD1_RS13600	COG4067	protein conserved in archaea
RD1_RS13600	COG0189	ligase activity
RD1_RS13605	COG2151	metal-sulfur cluster biosynthetic enzyme
RD1_RS13610	COG0110	maltose O-acetyltransferase activity
RD1_RS13615	COG0316	Belongs to the HesB IscA family
RD1_RS13620	COG0149	triose-phosphate isomerase activity
RD1_RS13630	COG1522	sequence-specific DNA binding
RD1_RS13635	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD1_RS13635	COG1648	precorrin-2 dehydrogenase activity
RD1_RS13645	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RD1_RS13650	COG0175	sulfate reduction
RD1_RS13665	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RD1_RS13695	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
RD1_RS13710	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
RD1_RS13725	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RD1_RS13730	COG2354	Protein conserved in bacteria
RD1_RS13740	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RD1_RS13745	COG0517	IMP dehydrogenase activity
RD1_RS13745	COG0516	GMP reductase activity
RD1_RS13765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RD1_RS13775	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD1_RS13790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RD1_RS13800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RD1_RS13805	COG2833	Protein of unknown function (DUF455)
RD1_RS13810	COG0739	heme binding
RD1_RS13830	COG0126	phosphoglycerate kinase activity
RD1_RS13840	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
RD1_RS13845	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD1_RS13845	COG0022	dehydrogenase e1 component
RD1_RS13850	COG0508	dehydrogenase complex catalyzes the overall conversion of
RD1_RS13930	COG4695	Portal protein
RD1_RS13945	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
RD1_RS13950	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD1_RS13960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RD1_RS13970	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RD1_RS13975	COG3038	cytochrome b561
RD1_RS13980	COG2353	YceI-like domain
RD1_RS13985	COG0360	Binds together with S18 to 16S ribosomal RNA
RD1_RS13990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RD1_RS13995	COG0359	binds to the 23S rRNA
RD1_RS14010	COG0544	peptidyl-prolyl cis-trans isomerase activity
RD1_RS14015	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
RD1_RS14030	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
RD1_RS14035	COG0248	Ppx GppA phosphatase
RD1_RS14045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RD1_RS14060	COG0643	Histidine kinase
RD1_RS14060	COG2198	Histidine kinase
RD1_RS14060	COG0784	Response regulator, receiver
RD1_RS14070	COG0835	chemotaxis
RD1_RS14075	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RD1_RS14080	COG0745	RESPONSE REGULATOR receiver
RD1_RS14095	COG2801	Transposase and inactivated derivatives
RD1_RS14140	COG3254	rhamnose metabolic process
RD1_RS14145	COG1172	Belongs to the binding-protein-dependent transport system permease family
RD1_RS14150	COG1172	Belongs to the binding-protein-dependent transport system permease family
RD1_RS14155	COG1129	ABC transporter
RD1_RS14170	COG3347	Dehydrogenase
RD1_RS14170	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS14175	COG4952	isomerase
RD1_RS14180	COG4191	Histidine kinase
RD1_RS14190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RD1_RS14195	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
RD1_RS14205	COG4974	Belongs to the 'phage' integrase family
RD1_RS14210	COG4536	flavin adenine dinucleotide binding
RD1_RS14230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RD1_RS14235	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS14240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS14260	COG1309	transcriptional regulator
RD1_RS14300	COG0105	UTP biosynthetic process
RD1_RS14305	COG0488	(ABC) transporter
RD1_RS14315	COG2095	MarC family integral membrane protein
RD1_RS14320	COG3577	Aspartyl protease
RD1_RS14330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RD1_RS14355	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RD1_RS14360	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
RD1_RS14370	COG2890	protein-(glutamine-N5) methyltransferase activity
RD1_RS14375	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RD1_RS14395	COG0010	Belongs to the arginase family
RD1_RS14400	COG1473	amidohydrolase
RD1_RS14405	COG3956	TIGRFAM MazG family protein
RD1_RS14420	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
RD1_RS14430	COG0513	Belongs to the DEAD box helicase family
RD1_RS14440	COG0697	spore germination
RD1_RS14445	COG0148	phosphopyruvate hydratase activity
RD1_RS14455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
RD1_RS14460	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
RD1_RS14465	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RD1_RS14480	COG0488	(ABC) transporter
RD1_RS14500	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RD1_RS14505	COG0416	fatty acid biosynthetic process
RD1_RS14510	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RD1_RS14515	COG0776	regulation of translation
RD1_RS14530	COG0717	Belongs to the dCTP deaminase family
RD1_RS14535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
RD1_RS14540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
RD1_RS14545	COG1472	Belongs to the glycosyl hydrolase 3 family
RD1_RS14555	COG0018	arginyl-trna synthetase
RD1_RS14560	COG0232	Belongs to the dGTPase family. Type 2 subfamily
RD1_RS14565	COG0316	Belongs to the HesB IscA family
RD1_RS14615	COG2814	Major facilitator Superfamily
RD1_RS14625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
RD1_RS14630	COG0215	cysteine-tRNA ligase activity
RD1_RS14660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RD1_RS14675	COG1278	Cold shock
RD1_RS14680	COG0259	pyridoxamine-phosphate oxidase activity
RD1_RS14685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD1_RS14690	COG1280	lysine exporter protein (LysE YggA)
RD1_RS14695	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
RD1_RS14710	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RD1_RS14735	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RD1_RS14740	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RD1_RS14745	COG0134	indole-3-glycerol-phosphate synthase activity
RD1_RS14750	COG0315	cyclic pyranopterin monophosphate synthase activity
RD1_RS14755	COG0303	'Molybdopterin
RD1_RS14760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
RD1_RS14765	COG2333	competence protein COMEC
RD1_RS14765	COG0658	competence protein
RD1_RS14770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RD1_RS14775	COG0372	Belongs to the citrate synthase family
RD1_RS14785	COG1024	Enoyl-CoA hydratase
RD1_RS14790	COG3088	subunit of a heme lyase
RD1_RS14795	COG1138	Cytochrome C-type biogenesis protein
RD1_RS14810	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
RD1_RS14815	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
RD1_RS14820	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RD1_RS14835	COG0583	DNA-binding transcription factor activity
RD1_RS14840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RD1_RS14855	COG0418	dihydroorotase activity
RD1_RS14860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
RD1_RS14865	COG0305	Participates in initiation and elongation during chromosome replication
RD1_RS14875	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
RD1_RS14880	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RD1_RS14885	COG1127	ABC transporter
RD1_RS14905	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RD1_RS14910	COG0300	oxidoreductase activity
RD1_RS14915	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
RD1_RS14920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RD1_RS14935	COG0805	protein transport
RD1_RS14940	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD1_RS14945	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RD1_RS14975	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS14980	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
RD1_RS14985	COG0513	Belongs to the DEAD box helicase family
RD1_RS14995	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RD1_RS15005	COG1007	ATP synthesis coupled electron transport
RD1_RS15020	COG0713	ATP synthesis coupled electron transport
RD1_RS15040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD1_RS15045	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
RD1_RS15085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RD1_RS15085	COG3743	rRNA binding
RD1_RS15095	COG0649	NAD binding
RD1_RS15110	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD1_RS15115	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RD1_RS15125	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
RD1_RS15130	COG1024	Enoyl-CoA hydratase
RD1_RS15150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
RD1_RS15160	COG3047	cAMP biosynthetic process
RD1_RS15165	COG1960	acyl-CoA dehydrogenase activity
RD1_RS15170	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RD1_RS15175	COG0546	phosphoglycolate phosphatase activity
RD1_RS15180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
RD1_RS15195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RD1_RS15200	COG1519	Transferase
RD1_RS15210	COG1473	amidohydrolase
RD1_RS15230	COG0601	transmembrane transport
RD1_RS15235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RD1_RS15245	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
RD1_RS15260	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS15270	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
RD1_RS15275	COG0308	aminopeptidase N
RD1_RS15280	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS15305	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RD1_RS15335	COG0484	heat shock protein binding
RD1_RS15350	COG0006	proline dipeptidase activity
RD1_RS15370	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RD1_RS15375	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
RD1_RS15385	COG0849	cell division
RD1_RS15390	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
RD1_RS15395	COG1181	Belongs to the D-alanine--D-alanine ligase family
RD1_RS15400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
RD1_RS15410	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
RD1_RS15415	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RD1_RS15425	COG2081	HI0933 family
RD1_RS15430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RD1_RS15435	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
RD1_RS15445	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RD1_RS15460	COG0275	rRNA processing
RD1_RS15465	COG2001	Belongs to the MraZ family
RD1_RS15470	COG0489	protein tyrosine kinase activity
RD1_RS15485	COG0210	DNA helicase
RD1_RS15490	COG1304	FMN binding
RD1_RS15495	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
RD1_RS15515	COG2801	Transposase and inactivated derivatives
RD1_RS15520	COG2801	Transposase and inactivated derivatives
RD1_RS15535	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
RD1_RS15550	COG0287	Prephenate dehydrogenase
RD1_RS15555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
RD1_RS15560	COG2755	lipolytic protein G-D-S-L family
RD1_RS15560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
RD1_RS15565	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RD1_RS15570	COG0519	Catalyzes the synthesis of GMP from XMP
RD1_RS15590	COG0583	DNA-binding transcription factor activity
RD1_RS15605	COG0142	geranyltranstransferase activity
RD1_RS15610	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
RD1_RS15630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RD1_RS15645	COG1763	Mo-molybdopterin cofactor biosynthetic process
RD1_RS15650	COG0746	molybdenum cofactor guanylyltransferase activity
RD1_RS15690	COG1960	acyl-CoA dehydrogenase activity
RD1_RS15695	COG0009	L-threonylcarbamoyladenylate synthase
RD1_RS15700	COG1678	Uncharacterized ACR, COG1678
RD1_RS15720	COG0521	Mo-molybdopterin cofactor biosynthetic process
RD1_RS15725	COG1280	lysine exporter protein (LysE YggA)
RD1_RS15730	COG1573	uracil-dna glycosylase
RD1_RS15735	COG0540	Belongs to the ATCase OTCase family
RD1_RS15745	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RD1_RS15750	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
RD1_RS15760	COG1917	Cupin 2, conserved barrel domain protein
RD1_RS15780	COG0277	FAD linked oxidase domain protein
RD1_RS15785	COG0405	Gamma-glutamyltransferase
RD1_RS15800	COG0604	alcohol dehydrogenase
RD1_RS15840	COG0210	DNA helicase
RD1_RS15850	COG2801	Transposase and inactivated derivatives
RD1_RS15875	COG2801	Transposase and inactivated derivatives
RD1_RS15915	COG0642	Histidine kinase
RD1_RS15920	COG0745	RESPONSE REGULATOR receiver
RD1_RS15935	COG1686	Belongs to the peptidase S11 family
RD1_RS15940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
RD1_RS15950	COG0084	hydrolase, TatD family'
RD1_RS15955	COG0321	lipoyl(octanoyl) transferase activity
RD1_RS15955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
RD1_RS15980	COG0006	proline dipeptidase activity
RD1_RS15985	COG3608	succinylglutamate desuccinylase aspartoacylase
RD1_RS15990	COG0546	phosphoglycolate phosphatase activity
RD1_RS16005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD1_RS16015	COG1120	ATPase activity
RD1_RS16030	COG1566	PFAM secretion protein HlyD family protein
RD1_RS16050	COG0596	Alpha beta hydrolase
RD1_RS16075	COG1435	thymidine kinase activity
RD1_RS16085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RD1_RS16105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
RD1_RS16115	COG1496	oxidoreductase activity
RD1_RS16120	COG1522	sequence-specific DNA binding
RD1_RS16125	COG0492	ferredoxin-NADP+ reductase activity
RD1_RS16150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RD1_RS16155	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
RD1_RS16160	COG3454	Phosphonate metabolism
RD1_RS16180	COG0459	protein refolding
RD1_RS16185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RD1_RS16200	COG1227	inorganic diphosphatase activity
RD1_RS16210	COG2030	dehydratase
RD1_RS16215	COG0196	riboflavin kinase activity
RD1_RS16220	COG2983	Belongs to the UPF0260 family
RD1_RS16230	COG2267	carboxylic ester hydrolase activity
RD1_RS16255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
RD1_RS16260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RD1_RS16265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
RD1_RS16270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
RD1_RS16275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RD1_RS16285	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
RD1_RS16295	COG0514	ATP-dependent DNA helicase (RecQ)
RD1_RS16320	COG2212	antiporter activity
RD1_RS16325	COG1863	multisubunit Na H antiporter MnhE subunit
RD1_RS16330	COG0651	ATP synthesis coupled electron transport
RD1_RS16335	COG1006	Multisubunit Na H antiporter MnhC subunit
RD1_RS16340	COG2111	Na H antiporter
RD1_RS16340	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD1_RS16355	COG0131	Imidazoleglycerol-phosphate dehydratase
RD1_RS16360	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
RD1_RS16375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RD1_RS16380	COG0107	imidazoleglycerol-phosphate synthase activity
RD1_RS16385	COG0140	phosphoribosyl-ATP diphosphatase activity
RD1_RS16390	COG1832	CoA-binding protein
RD1_RS16400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RD1_RS16410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
RD1_RS16415	COG0395	ABC-type sugar transport system, permease component
RD1_RS16420	COG1175	transmembrane transport
RD1_RS16435	COG1349	DNA-binding transcription factor activity
RD1_RS16445	COG3842	ATPase activity
RD1_RS16465	COG2197	response regulator
RD1_RS16490	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
RD1_RS16510	COG0559	Belongs to the binding-protein-dependent transport system permease family
RD1_RS16530	COG1566	PFAM secretion protein HlyD family protein
RD1_RS16535	COG0745	RESPONSE REGULATOR receiver
RD1_RS16540	COG0784	Response regulator, receiver
RD1_RS16540	COG2198	Histidine kinase
RD1_RS16540	COG2205	protein histidine kinase activity
RD1_RS16560	COG1129	ABC transporter
RD1_RS16590	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS16595	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
RD1_RS16595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
RD1_RS16605	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
RD1_RS16610	COG0352	thiamine-phosphate diphosphorylase activity
RD1_RS16620	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RD1_RS16635	COG4221	oxidoreductase activity
RD1_RS16650	COG1175	transmembrane transport
RD1_RS16655	COG0395	ABC-type sugar transport system, permease component
RD1_RS16660	COG1653	transport
RD1_RS16665	COG3842	ATPase activity
RD1_RS16670	COG1063	alcohol dehydrogenase
RD1_RS16675	COG0698	ribose 5-phosphate isomerase
RD1_RS16680	COG0149	triose-phosphate isomerase activity
RD1_RS16695	COG1070	Carbohydrate kinase
RD1_RS16710	COG0235	Class ii aldolase
RD1_RS16725	COG3842	ATPase activity
RD1_RS16730	COG3842	ATPase activity
RD1_RS16740	COG1175	transmembrane transport
RD1_RS16745	COG1653	transport
RD1_RS16755	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
RD1_RS16790	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
RD1_RS16800	COG0179	Fumarylacetoacetate (FAA) hydrolase
RD1_RS16810	COG0512	Glutamine amidotransferase of anthranilate synthase
RD1_RS16810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RD1_RS16830	COG0697	spore germination
RD1_RS16865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
RD1_RS16870	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
RD1_RS16885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RD1_RS16890	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
RD1_RS16900	COG1228	amidohydrolase
RD1_RS16905	COG2986	histidine ammonia-lyase
RD1_RS16915	COG1804	L-carnitine dehydratase bile acid-inducible protein F
RD1_RS16920	COG1960	acyl-CoA dehydrogenase activity
RD1_RS16925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
RD1_RS16940	COG2863	cytochrome
RD1_RS16950	COG2003	Belongs to the UPF0758 family
RD1_RS16970	COG0326	Molecular chaperone. Has ATPase activity
RD1_RS16980	COG0025	NhaP-type Na H and K H
RD1_RS16985	COG2264	protein methyltransferase activity
RD1_RS17000	COG0673	inositol 2-dehydrogenase activity
RD1_RS17005	COG1070	Carbohydrate kinase
RD1_RS17010	COG2115	Belongs to the xylose isomerase family
RD1_RS17015	COG2072	flavoprotein involved in K transport
RD1_RS17040	COG1215	transferase activity, transferring glycosyl groups
RD1_RS17045	COG0366	Alpha amylase catalytic
RD1_RS17060	COG0395	ABC-type sugar transport system, permease component
RD1_RS17065	COG1175	transmembrane transport
RD1_RS17075	COG3842	ATPase activity
RD1_RS17080	COG1609	Transcriptional regulator
RD1_RS17090	COG1132	(ABC) transporter
RD1_RS17100	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RD1_RS17105	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
RD1_RS17115	COG0668	transmembrane transport
RD1_RS17135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS17145	COG3842	ATPase activity
RD1_RS17165	COG1175	transmembrane transport
RD1_RS17205	COG0667	Aldo Keto reductase
RD1_RS17220	COG0583	DNA-binding transcription factor activity
RD1_RS17225	COG1069	ribulokinase activity
RD1_RS17240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
RD1_RS17270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
RD1_RS17285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
RD1_RS17290	COG3485	protocatechuate 3,4-dioxygenase
RD1_RS17295	COG3485	protocatechuate 3,4-dioxygenase
RD1_RS17300	COG0837	glucose binding
RD1_RS17310	COG0156	8-amino-7-oxononanoate synthase activity
RD1_RS17330	COG3622	Belongs to the hyi family
RD1_RS17335	COG0235	Class ii aldolase
RD1_RS17340	COG3395	kinase activity
RD1_RS17345	COG2084	Dehydrogenase
RD1_RS17360	COG0473	3-isopropylmalate dehydrogenase activity
RD1_RS17375	COG0829	nickel cation binding
RD1_RS17380	COG0831	urea catabolic process
RD1_RS17385	COG0832	Belongs to the urease beta subunit family
RD1_RS17400	COG0804	urea catabolic process
RD1_RS17410	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
RD1_RS17415	COG0830	nickel cation binding
RD1_RS17420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
RD1_RS17425	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
RD1_RS17430	COG1609	Transcriptional regulator
RD1_RS17435	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD1_RS17440	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS17445	COG1063	alcohol dehydrogenase
RD1_RS17470	COG0778	Nitroreductase
RD1_RS17480	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD1_RS17480	COG1648	precorrin-2 dehydrogenase activity
RD1_RS17485	COG1797	cobyrinic acid a,c-diamide synthase activity
RD1_RS17490	COG2875	Belongs to the precorrin methyltransferase family
RD1_RS17505	COG2099	Precorrin-6x reductase
RD1_RS17545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
RD1_RS17550	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
RD1_RS17605	COG0438	transferase activity, transferring glycosyl groups
RD1_RS17620	COG0367	asparagine synthase
RD1_RS17660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS17680	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS17700	COG0583	DNA-binding transcription factor activity
RD1_RS17710	COG2207	Transcriptional regulator
RD1_RS17730	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS17735	COG1082	Xylose isomerase domain protein TIM barrel
RD1_RS17765	COG3842	ATPase activity
RD1_RS17770	COG0395	ABC-type sugar transport system, permease component
RD1_RS17785	COG3842	ATPase activity
RD1_RS17795	COG1609	Transcriptional regulator
RD1_RS17805	COG2376	Dihydroxyacetone kinase
RD1_RS17825	COG0012	GTP binding
RD1_RS17835	COG0159	tryptophan synthase activity
RD1_RS17840	COG1304	FMN binding
RD1_RS17850	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
RD1_RS17855	COG0193	aminoacyl-tRNA hydrolase activity
RD1_RS17880	COG0133	tryptophan synthase activity
RD1_RS17890	COG0135	phosphoribosylanthranilate isomerase activity
RD1_RS17900	COG0776	regulation of translation
RD1_RS17905	COG0539	negative regulation of cytoplasmic translation
RD1_RS17915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
RD1_RS17920	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
RD1_RS17925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RD1_RS17930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RD1_RS17935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RD1_RS17940	COG1253	flavin adenine dinucleotide binding
RD1_RS17945	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RD1_RS17950	COG1702	phosphate starvation-inducible protein PhoH
RD1_RS17955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RD1_RS17965	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
RD1_RS17970	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RD1_RS17975	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RD1_RS17985	COG1047	Peptidyl-prolyl cis-trans
RD1_RS18005	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
RD1_RS18030	COG4948	Mandelate Racemase Muconate Lactonizing
RD1_RS18055	COG1609	Transcriptional regulator
RD1_RS18060	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS18070	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RD1_RS18085	COG0395	ABC-type sugar transport system, permease component
RD1_RS18095	COG3842	ATPase activity
RD1_RS18100	COG1960	acyl-CoA dehydrogenase activity
RD1_RS18105	COG0583	DNA-binding transcription factor activity
RD1_RS18110	COG2135	peptidase activity
RD1_RS18115	COG0737	Belongs to the 5'-nucleotidase family
RD1_RS18130	COG0534	Mate efflux family protein
RD1_RS18155	COG2197	response regulator
RD1_RS18165	COG1960	acyl-CoA dehydrogenase activity
RD1_RS18175	COG0625	glutathione transferase activity
RD1_RS18180	COG0183	Belongs to the thiolase family
RD1_RS18185	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD1_RS18185	COG1024	Enoyl-CoA hydratase
RD1_RS18190	COG0318	PFAM AMP-dependent synthetase and ligase
RD1_RS18200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RD1_RS18205	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
RD1_RS18210	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
RD1_RS18245	COG3237	CsbD-like
RD1_RS18250	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
RD1_RS18255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
RD1_RS18260	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD1_RS18275	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
RD1_RS18285	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS18290	COG1802	Transcriptional regulator
RD1_RS18300	COG1595	DNA-templated transcription, initiation
RD1_RS18325	COG1121	(ABC) transporter
RD1_RS18330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RD1_RS18355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RD1_RS18360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
RD1_RS18365	COG0049	tRNA binding
RD1_RS18370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RD1_RS18375	COG0697	spore germination
RD1_RS18380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
RD1_RS18390	COG0085	RNA polymerase activity
RD1_RS18395	COG0222	ribosome binding
RD1_RS18400	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RD1_RS18405	COG0081	regulation of translation
RD1_RS18410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RD1_RS18415	COG0250	Participates in transcription elongation, termination and antitermination
RD1_RS18440	COG3842	ATPase activity
RD1_RS18535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
RD1_RS18570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RD1_RS18575	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RD1_RS18585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
RD1_RS18590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
RD1_RS18595	COG0124	histidyl-tRNA synthetase
RD1_RS18615	COG1529	Aldehyde oxidase and xanthine dehydrogenase
RD1_RS18625	COG3845	ABC transporter
RD1_RS18630	COG4603	Belongs to the binding-protein-dependent transport system permease family
RD1_RS18635	COG1079	Belongs to the binding-protein-dependent transport system permease family
RD1_RS18660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RD1_RS18665	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
RD1_RS18680	COG0589	response to stress
RD1_RS18685	COG0314	molybdopterin synthase activity
RD1_RS18695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
RD1_RS18705	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS18725	COG0842	Transport permease protein
RD1_RS18730	COG1131	(ABC) transporter
RD1_RS18735	COG0697	spore germination
RD1_RS18745	COG0604	alcohol dehydrogenase
RD1_RS18745	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS18745	COG3321	synthase
RD1_RS18750	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
RD1_RS18780	COG1414	Transcriptional regulator
RD1_RS18795	COG2308	Evidence 4 Homologs of previously reported genes of
RD1_RS18820	COG2358	TRAP transporter, solute receptor (TAXI family
RD1_RS18830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RD1_RS18850	COG0395	ABC-type sugar transport system, permease component
RD1_RS18855	COG1175	transmembrane transport
RD1_RS18860	COG3842	ATPase activity
RD1_RS18865	COG3842	ATPase activity
RD1_RS18885	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD1_RS18890	COG3842	ATPase activity
RD1_RS18895	COG1176	ABC-type spermidine putrescine transport system, permease component I
RD1_RS18900	COG1177	transmembrane transport
RD1_RS18905	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
RD1_RS18915	COG2072	flavoprotein involved in K transport
RD1_RS18945	COG3002	Belongs to the UPF0753 family
RD1_RS18950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RD1_RS18970	COG0583	DNA-binding transcription factor activity
RD1_RS18975	COG2351	hydroxyisourate hydrolase activity
RD1_RS18985	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
RD1_RS19010	COG1309	transcriptional regulator
RD1_RS19015	COG3246	L-lysine catabolic process to acetate
RD1_RS19025	COG1250	3-hydroxyacyl-CoA dehydrogenase
RD1_RS19030	COG1028	Short-chain dehydrogenase reductase Sdr
RD1_RS19050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
RD1_RS19050	COG1648	precorrin-2 dehydrogenase activity
RD1_RS19060	COG0243	molybdopterin cofactor binding
RD1_RS19065	COG2146	nitrite reductase [NAD(P)H] activity
RD1_RS19070	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
RD1_RS19075	COG1116	anion transmembrane transporter activity
RD1_RS19080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
RD1_RS19085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RD1_RS19085	COG1116	anion transmembrane transporter activity
RD1_RS19090	COG1116	anion transmembrane transporter activity
RD1_RS19090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
RD1_RS19095	COG3707	response regulator
RD1_RS19165	COG3720	iron ion transport
RD1_RS19170	COG4558	Periplasmic binding protein
RD1_RS19175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RD1_RS19180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
RD1_RS19185	COG2329	Antibiotic biosynthesis monooxygenase
RD1_RS19205	COG0811	peptide transport
RD1_RS19240	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RD1_RS19250	COG2089	acid synthase
RD1_RS19260	COG1083	cytidylyl-transferase
RD1_RS19265	COG3300	MHYT domain
RD1_RS19265	COG5001	Diguanylate cyclase
RD1_RS19370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
RD1_RS19375	COG3383	formate dehydrogenase (NAD+) activity
RD1_RS19380	COG2759	Belongs to the formate--tetrahydrofolate ligase family
RD1_RS19385	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD1_RS19390	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RD1_RS19405	COG2379	hydroxypyruvate reductase
RD1_RS19415	COG2197	response regulator
RD1_RS19425	COG0045	succinate-CoA ligase (ADP-forming) activity
RD1_RS19430	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RD1_RS19440	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
RD1_RS19445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
RD1_RS19455	COG0069	glutamate synthase activity
RD1_RS19460	COG2218	PFAM glutamate synthase alpha subunit domain protein
RD1_RS19465	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RD1_RS19515	COG0446	pyridine nucleotide-disulphide oxidoreductase
RD1_RS19515	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS20365	COG0404	The glycine cleavage system catalyzes the degradation of glycine
RD1_RS20400	COG0668	transmembrane transport
RD1_RS20425	COG2205	protein histidine kinase activity
RD1_RS20480	COG0840	transmembrane signaling receptor activity
RD1_RS20485	COG0840	transmembrane signaling receptor activity
RD1_RS20550	COG3119	arylsulfatase activity